CN219595239U - Radiopharmaceutical partial shipment device - Google Patents

Abstract

The utility model provides a radioactive medicine split charging device which comprises a preparation system and a cover opening and rolling system. The medicine is split-packed by using the five-way three-way valve controlled by the motor, so that the raw materials, auxiliary materials and diluent can be conveyed in multiple ways, and the purpose of automatic preparation of the radioactive medicine is achieved. The whole process has good tightness, and the pipelines between the raw materials are mutually independent, so that pollution is avoided. The medicine preparation efficiency and the safety are high, and meanwhile, the radiation hazard of operators is reduced.

Description

Radiopharmaceutical partial shipment device

Technical Field

The utility model belongs to the technical field of radiopharmaceuticals, and particularly relates to a radiopharmaceuticals split charging device.

Background

At present, when the radiopharmaceuticals need to be split into micro-doses, technicians are often required to manually prepare and dilute the radiopharmaceuticals due to small-volume small doses. The process has low working efficiency, prolongs the production period of the radiopharmaceuticals, and has certain radiation damage to technicians. The automatic dispensing system of radiopharmaceuticals developed at present needs peristaltic pumps for liquid transmission. Because peristaltic pumps for dispensing medications are not disposable consumables, to avoid contamination of the fluid being pumped, the pump needs to be properly cleaned and sterilized before or after use. In addition, for micro peristaltic pumps that require the delivery of micro-doses of fluid, the tubing within the pump is at risk of permanent deformation due to compression during storage, so the shelf life of the pump is short and the deformed tubing can affect the accuracy and reliability of the pump.

Disclosure of Invention

In order to solve the technical problems, the utility model provides a radioactive drug split charging device. The medicine is split-charged by using the five-way three-way valve controlled by the miniature precise servo motor, and compared with a peristaltic pump, the five-way three-way valve is simple to maintain, can be directly replaced after being used, and avoids secondary pollution. And can realize multi-channel conveying mother liquor, auxiliary materials and diluent to be split-charged, thus achieving the purpose of preparing the pharmaceutical preparation. The whole process has good tightness, and the pipelines between the raw materials are mutually independent, so that pollution is avoided. The medicine preparation efficiency and the safety are high, and meanwhile, the radiation hazard of operators is reduced.

In order to achieve the above purpose, the present utility model provides the following technical solutions:

a radioactive medicine split charging device comprises a preparation system and a cover opening and rolling system; wherein the preparation system comprises a five-way three-way valve, an injector, a mother liquor bottle, an auxiliary material bottle, a diluent bottle and an injection needle; the mother liquor bottle is provided with a mother liquor bottle conveying port and a mother liquor bottle empty port.

The five-way three-way valve comprises 5 valves, and the total of 7 valves can be connected with an external instrument. The mother liquor bottle conveying port, the mother liquor bottle empty port, the injector, the auxiliary material bottle, the diluent bottle and the injection needle are respectively connected with any valve port of any valve of the five-way three-way valve through pipes, the rest valve port is communicated with the atmospheric pressure, but the valve port connected with the mother liquor bottle conveying port and/or the injector cannot be arranged between the two valve ports connected with the mother liquor bottle empty port and the atmospheric pressure. The cover opening and rolling system comprises a bottle seat, a conveying track, a rubber plug gripper, an aluminum cover gripper and a rolling head.

Preferably, two valve ports of the leftmost valve of the five-way three-way valve are respectively connected with a mother liquor bottle conveying port and an injector, two valve ports of the rightmost valve are respectively connected with an empty port of the mother liquor bottle and an injection needle, and valve ports of the remaining three valves are randomly connected with atmospheric pressure, an auxiliary material bottle and a diluent bottle.

Specifically, the five-way three-way valve comprises five valves A-E from left to right; each valve comprises three valve ports, namely a left valve port, an upper valve port and a right valve port, and the right valve port and the left valve port of two adjacent valves are connected. Each valve has three opening paths, namely a left-upper path, a left-right path and a right-upper path, for example, when the left-upper path of the valve a is opened, the right valve port of the valve a is closed, and other paths operate in the same principle.

Preferably, the left valve port and the upper valve port of the valve A are respectively connected with a mother liquor bottle conveying port and an injector, the upper valve ports of the valves B-E are sequentially connected with an auxiliary material bottle, a diluent bottle, atmospheric pressure and a mother liquor bottle opposite air port, and the right valve port of the valve E is connected with an injection needle; the opening/closing of the valves A-E are respectively controlled by miniature precision servo motors.

Further, the mother liquor bottle conveying port is lower than the mother liquor bottle air-to-air port. Preferably, the mother liquor bottle conveying port is positioned at the bottom of the bottle, and the mother liquor bottle pair empty port is positioned at the bottle mouth.

Further, the bottle seat is mounted on a conveying rail and moves under the action of the conveying rail, and the conveying rail is controlled to be conveyed or stationary by a motor. The bottle seat main body is designed as a sinking cavity, and the diameter of the bottle seat main body is matched with that of the penicillin bottle so as to prevent the penicillin bottle from toppling over in the moving process; the bottom of the bottle seat is also provided with an air cylinder for controlling the descending or ascending of the bottle seat.

Preferably, the initial position of the bottle seat is arranged right below the injection needle.

A penicillin bottle sensor and an aluminum cap rubber plug sensor are also arranged above the side of the bottle seat; the penicillin bottle sensor is used for sensing whether a penicillin bottle occupies a position at the bottle seat or not, and aims to start a motor of the conveying track when sensing that the penicillin bottle occupies the position; the aluminum cover rubber plug sensor senses whether a rubber plug and an aluminum cover exist at the bottle mouth of the penicillin bottle, and the purpose is to perform preparation operation of the preparation once the rubber plug and the aluminum cover are not arranged at the bottle mouth of the penicillin bottle.

The rubber plug gripper, the aluminum cover gripper, the chuck and the injection needle are positioned above the bottle seat; the center positions of the rubber plug grip, the aluminum cover grip, the chuck, the injection needle and the bottle seat are positioned in the same plane; the rubber plug grip, the aluminum cover grip and the roller head are identical in height and equal to or slightly higher than the injection needle. The design ensures that the rubber plug gripper, the aluminum cover gripper and the rolling head can accurately act on the rubber plug or the aluminum cover; and the needle head is not higher than Yu Xilin bottle mouth when the medicine is divided, so that the liquid is prevented from splashing outside the bottle when the liquid flows out from the injection needle head. The rubber plug gripper, the aluminum cover gripper and the roller head are respectively controlled by respective pneumatic electromagnetic valves.

All operations of the device are controlled by a PLC system.

The utility model has the beneficial effects that: the utility model achieves the purposes of automatic preparation and split charging of the radiopharmaceuticals on one hand and solves the problem of application defects of peristaltic pumps on the other hand. The whole process of medicine split charging is automatically completed under the aseptic condition, and the preparation precision is high. And the consumable material of the preparation system can be directly replaced after the split charging is finished, so that secondary pollution is avoided, and the radiation risk of operators is reduced.

Drawings

FIG. 1 is a schematic view of the apparatus according to embodiment 1 of the present utility model;

wherein reference numerals are denoted as:

1-five-way three-way valve; 2-a syringe; 3-mother liquor bottle; 4-a mother liquor bottle conveying port; 5-mother liquor bottle butt-hole; 6, an auxiliary material bottle; 7-a diluent bottle; 8-an injection needle; 9-bottle base; 10-cylinder; 11-a transfer track; 12-rubber plug grippers; 13-aluminum cap grippers; 14-rolling heads; 15-penicillin bottle sensor; 16-aluminum cover rubber plug inductor.

Detailed Description

The structural features of the present utility model will be further described in conjunction with the drawings and examples to enable one skilled in the art to practice them in the light of the description. The preferred embodiments in the following description are by way of example only and other obvious variations will occur to those skilled in the art.

Example 1

As shown in fig. 1, the apparatus includes a formulation system and a capping system.

The preparation system comprises a five-way three-way valve (1), an injector (2), a mother liquor bottle (3), an auxiliary material bottle (6), a diluent bottle (7) and an injection needle (8). Wherein, mother liquor bottle (3) still includes mother liquor bottle delivery port (4) and mother liquor bottle empty mouth (5).

The uncapping and capping system comprises a bottle seat (9), a conveying track (11), a rubber plug gripper (12), an aluminum cap gripper (13) and a capping head (14).

The operation process is as follows:

and opening system software, setting the volumes of mother solution, auxiliary materials and diluent to be split into needed volumes, and starting the software.

The penicillin bottle is put into the bottle seat (9), at the moment, the penicillin bottle sensor (15) knows that the bottle seat (9) is in a occupying state, the motor of the conveying track (11) is started, the conveying track (11) moves the bottle seat (9) to the lower part of the aluminum cap gripper (13), the bottle seat (9) ascends under the action of the air cylinder (10) of the conveying track, the aluminum cap gripper (13) grabs the aluminum cap, the bottle seat (9) moves downwards, the conveying track (11) moves the bottle seat (9) to the lower part of the rubber plug gripper (12) again, the bottle seat (9) moves downwards after the rubber plug gripper (12) grabs the rubber plug, and returns to the initial position, and the aluminum cap rubber plug sensor (16) senses that the bottle mouth of the penicillin bottle has no rubber plug and aluminum cap, so that the uncapping operation is completed.

Then, the valve A of the five-way three-way valve (1) is opened at the left-upper valve, the valve B, C is in a left-right valve opening state, the valve D is opened at the right-upper valve, the valve E is opened at the left-upper valve, and the mother liquor flows into the injector (2); then the right-upper valve of the valve A is opened, the valves B-E are all in the left-right valve opening state, and the mother solution enters the penicillin bottle through the injection needle head (8). Then the left-upper opening of the valve B is opened, the valve A is still in the state of opening the right-upper opening, and after the auxiliary materials enter the injector (2), the left-right valves of the valves B-E are opened, and the auxiliary materials enter the penicillin bottle. In the principle, the diluent finally flows into the penicillin bottle to complete the preparation process.

After the preparation of the liquid medicine is completed, the conveying track (11) moves the bottle seat (9) to the lower part of the rubber plug grip (12), the bottle seat (9) moves upwards, the rubber plug grip (12) releases the rubber plug to be placed in the western Lin Pingkou, and the bottle seat (9) moves downwards. With the principle, the penicillin bottle moves to the aluminum cover gripper (13), the aluminum cover gripper (13) releases the aluminum cover, and the aluminum cover is lightly buckled on the rubber plug. Finally, the rubber plug and the aluminum cover are fastened under the action of the rolling head (14) to finish the cover rolling operation.

The foregoing has shown and described the basic principles, principal features and advantages of the utility model. It will be understood by those skilled in the art that the present utility model is not limited to the embodiments described above, and that the above embodiments and descriptions are merely illustrative of the principles of the present utility model, and various changes and modifications may be made therein without departing from the spirit and scope of the utility model, which is defined by the appended claims. The scope of the utility model is defined by the appended claims and equivalents thereof.

Claims (6)

1. The radioactive medicine split charging device is characterized by comprising a preparation system and a cover opening rolling and covering system;

wherein the preparation system comprises a five-way three-way valve, an injector, a mother liquor bottle, an auxiliary material bottle, a diluent bottle and an injection needle; the mother liquor bottle is provided with a mother liquor bottle conveying port and a mother liquor bottle empty port; the mother liquor bottle conveying port, the mother liquor bottle empty port, the injector, the auxiliary material bottle, the diluent bottle and the injection needle are respectively connected with any valve port of any valve of the five-way three-way valve through pipes, the rest valve port is communicated with the atmospheric pressure, but the valve port connected with the mother liquor bottle conveying port and/or the injector cannot be arranged between the two valve ports connected with the mother liquor bottle empty port and the atmospheric pressure;

the cover opening and rolling system comprises a bottle seat, a conveying track, a rubber plug gripper, an aluminum cover gripper and a rolling head.

2. The radiopharmaceutical dispensing device of claim 1, wherein two ports of a leftmost valve of the five-way three-way valve are respectively connected with a mother liquor bottle delivery port and a syringe, and two ports of a rightmost valve of the five-way three-way valve are respectively connected with a mother liquor bottle empty port and a syringe needle.

3. The radiopharmaceutical dispensing device of claim 1 or 2, wherein said mother liquor bottle delivery port is lower than the mother liquor bottle-to-empty port.

4. The radiopharmaceutical dispensing device of claim 1 wherein said vial holder is mounted on a conveyor rail and is moved by the action of the conveyor rail.

5. The radiopharmacy dispensing apparatus of claim 1, wherein the body of the bottle holder is of a submerged cavity design with a cylinder mounted at the bottom; and a penicillin bottle sensor and an aluminum cap rubber plug sensor are also arranged above the side of the bottle seat.

6. The radiopharmaceutical dispensing device of claim 1, wherein said rubber stopper grip, aluminum cap grip, stopper, injection needle are located above the bottle base; the center positions of the rubber plug grip, the aluminum cover grip, the chuck, the injection needle and the bottle seat are positioned in the same plane; the rubber plug grip, the aluminum cover grip and the roller head are identical in height and equal to or slightly higher than the injection needle.