WO2018072195A1 - 血压检测信号采样补偿方法和装置以及血压信号采集系统 - Google Patents

血压检测信号采样补偿方法和装置以及血压信号采集系统 Download PDF

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WO2018072195A1
WO2018072195A1 PCT/CN2016/102823 CN2016102823W WO2018072195A1 WO 2018072195 A1 WO2018072195 A1 WO 2018072195A1 CN 2016102823 W CN2016102823 W CN 2016102823W WO 2018072195 A1 WO2018072195 A1 WO 2018072195A1
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sampling
sampling module
module
ppg
ecg
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PCT/CN2016/102823
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English (en)
French (fr)
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姜永涛
朱萸
许培达
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华为技术有限公司
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Priority to US16/072,265 priority Critical patent/US11375908B2/en
Priority to PCT/CN2016/102823 priority patent/WO2018072195A1/zh
Priority to CN201680029853.5A priority patent/CN108471960A/zh
Publication of WO2018072195A1 publication Critical patent/WO2018072195A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A61B5/02108—Measuring pressure in heart or blood vessels from analysis of pulse wave characteristics
    • A61B5/02125—Measuring pressure in heart or blood vessels from analysis of pulse wave characteristics of pulse wave propagation time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/318—Heart-related electrical modalities, e.g. electrocardiography [ECG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7225—Details of analog processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7271—Specific aspects of physiological measurement analysis
    • A61B5/7278—Artificial waveform generation or derivation, e.g. synthesising signals from measured signals
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F1/00—Details not covered by groups G06F3/00 - G06F13/00 and G06F21/00
    • G06F1/04—Generating or distributing clock signals or signals derived directly therefrom
    • G06F1/12—Synchronisation of different clock signals provided by a plurality of clock generators
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
    • G16H40/60—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
    • G16H40/63—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • H—ELECTRICITY
    • H03—ELECTRONIC CIRCUITRY
    • H03M—CODING; DECODING; CODE CONVERSION IN GENERAL
    • H03M1/00—Analogue/digital conversion; Digital/analogue conversion
    • H03M1/12—Analogue/digital converters
    • H03M1/124—Sampling or signal conditioning arrangements specially adapted for A/D converters
    • H03M1/1245—Details of sampling arrangements or methods
    • H03M1/1255—Synchronisation of the sampling frequency or phase to the input frequency or phase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/024—Detecting, measuring or recording pulse rate or heart rate
    • A61B5/02416—Detecting, measuring or recording pulse rate or heart rate using photoplethysmograph signals, e.g. generated by infrared radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/024—Detecting, measuring or recording pulse rate or heart rate
    • A61B5/0245—Detecting, measuring or recording pulse rate or heart rate by using sensing means generating electric signals, i.e. ECG signals

Definitions

  • Embodiments of the present invention relate to the field of blood pressure detection technologies, and in particular, to a blood pressure detection signal sampling compensation method and apparatus, and a blood pressure signal acquisition system.
  • Blood Pressure is the side pressure acting on the wall of a blood vessel per unit area when the blood flows in a blood vessel, that is, the pressure. Blood pressure is an important physiological indicator reflecting the heart and blood vessel function of the human body. It has important significance in disease diagnosis, quality effect observation and prognosis judgment.
  • PWV Pulse Wave Velocity
  • PTT Pulse Transit Time
  • Using PTT to measure blood pressure does not require the subject to use the cuff, does not cause any damage to the tissue or blood vessels under the measuring device, can provide users with a convenient and comfortable blood pressure measurement method, and the structure can be small and light, suitable for carrying around Or the application of wearable products.
  • the PTT measurement method basically uses synchronous electrocardiogram (ECG) signals and photoplethysmography (PPG) signals to identify the maximum points of the R wave and PPG signals of the ECG signal, and obtain the delay time PTT.
  • ECG electrocardiogram
  • PPG photoplethysmography
  • Embodiments of the present invention provide a blood pressure detecting signal sampling compensation method and device, and a blood pressure signal An acquisition system for improving the accuracy of blood pressure detection signals.
  • the first aspect provides a blood pressure detecting signal sampling compensation method, including:
  • the sampling frequency deviation of the standard periodic signal exceeds the preset frequency threshold by the ECG sampling module, the sampling frequency of the ECG sampling module is compensated, so that the ECG sampling module samples the standard periodic signal.
  • the frequency deviation is lower than the preset frequency threshold
  • the sampling frequency deviation of the PPG sampling module exceeds the preset frequency threshold, the sampling frequency of the PPG sampling module is compensated, so that the PPG sampling module samples the standard periodic signal.
  • the frequency deviation is lower than the preset frequency threshold
  • the sampling start time of the ECG sampling module or the PPG sampling module is compensated, So that the difference between the sampling end time of the ECG sampling module and the PPG sampling module for the standard periodic signal is lower than a preset time threshold.
  • the blood pressure detecting signal sampling compensation method samples the ECG signal and the PPG signal of the user to be tested by controlling the ECG sampling module and the PPG sampling module, and samples the standard periodic signal to obtain the sampling end of the ECG signal and the PPG signal.
  • the error of the PTT determined by the PPG sampling module is also within the allowable range, so that the error of the blood pressure value measured by the PTT method is within the allowable range, and the accuracy of the blood pressure measurement by the PTT method is improved.
  • the method before the controlling the ECG sampling module and the PPG sampling module simultaneously sampling the standard periodic signal, the method further includes:
  • the control ECG sampling module and the PPG sampling module simultaneously sample the standard periodic signal include:
  • the high-precision clock signal ensures accurate recording of the start sampling time and sampling end time of the ECG sampling module and the PPG sampling module, as well as ensuring the frequency stability of the standard periodic signal generated based on the high-precision clock signal.
  • the high-precision clock signal is generated by any one of a high-precision system crystal oscillator, a synchronous calibration clock signal of a Bluetooth module, and a synchronous calibration clock signal of a WiFi module;
  • the high precision clock signal includes:
  • Any one of a sine wave signal, a triangular wave signal, and a sawtooth wave signal is any one of a sine wave signal, a triangular wave signal, and a sawtooth wave signal.
  • the method before the controlling the ECG sampling module and the PPG sampling module respectively sampling the standard periodic signal, the method further includes:
  • the standard period signal is generated based on the high precision clock signal.
  • control ECG sampling module and the PPG sampling module respectively sample the standard periodic signal, including:
  • ⁇ f 10
  • , ⁇ f 20
  • the sampling frequency of the ECG sampling module is compensated, so that the sampling frequency deviation of the standard periodic signal by the ECG sampling module is lower than a preset frequency threshold, including:
  • the sampling frequency deviation of the standard period signal exceeds a preset frequency threshold by the PPG sampling module, the sampling frequency of the PPG sampling module is compensated, so that the PPG sampling module pairs the standard periodic signal
  • the sampling frequency deviation is lower than the preset frequency threshold, including:
  • the ECG sampling module and the PPG sampling module sample the ECG
  • the sampling start time of the module or the PPG sampling module is compensated, so that the difference between the sampling end time of the standard period signal of the ECG sampling module and the PPG sampling module is lower than a preset time threshold, including:
  • the sampling trigger time t p1 of the ECG sampling module is delayed, and T 0 ⁇
  • ⁇ t 21 , t p2 is satisfied
  • T 0 is the preset time threshold
  • a blood pressure detecting signal sampling and compensating device comprising:
  • Control module for controlling the ECG sampling module and the PPG module to simultaneously input the standard period signal Line sampling
  • a calculation module configured to respectively obtain a sampling frequency and a sampling end time of the standard period signal by the ECG sampling module and the PPG sampling module;
  • a compensation module configured to compensate a sampling frequency of the ECG sampling module if the sampling frequency deviation of the standard periodic signal exceeds a preset frequency threshold by the ECG sampling module, so that the ECG sampling module The sampling frequency deviation of the standard periodic signal is lower than the preset frequency threshold; if the sampling frequency deviation of the standard periodic signal exceeds the preset frequency threshold by the PPG sampling module, the sampling frequency of the PPG sampling module is compensated to And causing, by the PPG sampling module, a sampling frequency deviation of the standard periodic signal to be lower than a preset frequency threshold; if the difference between the sampling end time of the standard periodic signal by the ECG sampling module and the PPG sampling module exceeds a preset a time threshold, the sampling start time of the ECG sampling module or the PPG sampling module is compensated, so that the difference between the sampling end time of the ECG sampling module and the PPG sampling module for the standard periodic signal is lower than Preset time threshold.
  • the blood pressure detection signal sampling compensation apparatus further includes: a clock module, configured to generate a high precision clock signal, the precision of the high precision clock signal being higher than the ECG sampling module and the The accuracy of the clock signal in the PPG sampling module is an order of magnitude higher;
  • the control module is configured to control the ECG sampling module and the PPG sampling module to simultaneously sample the standard periodic signal according to the high-precision clock signal; and record the ECG sampling module according to the high-precision clock signal And a sampling end time of the standard periodic signal by the PPG sampling module.
  • the high-precision clock signal is generated by any one of a high-precision system crystal oscillator, a synchronous calibration clock signal of a Bluetooth module, and a synchronous calibration clock signal of a WiFi module;
  • the high precision clock signal includes:
  • Any one of a sine wave signal, a triangular wave signal, and a sawtooth wave signal is any one of a sine wave signal, a triangular wave signal, and a sawtooth wave signal.
  • the calculating module is further configured to generate the standard periodic signal according to the high precision clock signal.
  • control module is specifically configured to control the ECG sampling module to sample the standard periodic signal, calculate a frequency f 1 of the sampled data, and control the PPG sampling.
  • the module samples the standard periodic signal and calculates the frequency f 2 of the sampled data;
  • , ⁇ f 20
  • the compensation module is specifically configured to reduce the number L of data sampled by the ECG sampling module if ⁇ f 10 >F 0 and f 1 >f 0 , ( ⁇ f 10 -F 0 ) ⁇ L ⁇ f 10 , using (F 1 -L) as the new sampling frequency of the ECG sampling module, where F 1 is the original sampling frequency of the ECG sampling module, and F 0 is a preset frequency threshold; if ⁇ f 10 >F 0 , and f 1 ⁇ f 0 , increasing the number M of data sampled by the ECG sampling module, ( ⁇ f 10 -F 0 ) ⁇ M ⁇ f 10 , using (F 1 +M) as the ECG
  • the new sampling frequency of the sampling module if ⁇ f 20 >F 0 and f 2 >f 0 , the number N of data sampled by the PPG sampling module is reduced, ( ⁇ f 20 -F 0 ) ⁇ N ⁇ f 20 , using (F 2 -N) as the new sampling frequency of the
  • , t 1 is a sampling end time of the standard periodic signal by the ECG sampling module, and t 2 is a sampling end time of the standard periodic signal by the PPG sampling module;
  • the compensation module is specifically configured to delay the sampling trigger time t p1 of the ECG sampling module if ⁇ t 21 >T 0 and t 2 >t 1 , and satisfy T 0 ⁇
  • the third aspect provides a blood pressure signal sampling system, including: an ECG sampling module, a PPG sampling module, and a processor;
  • the processor is configured to control the ECG sampling module and the PPG module to simultaneously sample the standard periodic signal; respectively obtain the sampling frequency and the sampling end time of the standard periodic signal by the ECG sampling module and the PPG sampling module; The sampling frequency of the ECG sampling module exceeds the preset frequency threshold, and the sampling frequency of the ECG sampling module is compensated, so that the sampling frequency deviation of the standard periodic signal by the ECG sampling module is low.
  • a preset frequency threshold if the sampling frequency deviation of the standard period signal by the PPG sampling module exceeds a pre- Setting a frequency threshold, the sampling frequency of the PPG sampling module is compensated, so that the sampling frequency deviation of the PPG sampling module for the standard periodic signal is lower than a preset frequency threshold; if the ECG sampling module and the Compensating the sampling start time of the ECG sampling module or the PPG sampling module by the PPG sampling module for the difference between the sampling end times of the standard periodic signals exceeds a preset time threshold, so that the ECG sampling module and the The difference between the sampling end time of the standard period signal of the PPG sampling module is lower than a preset time threshold.
  • the blood pressure signal sampling system further includes: a clock module, configured to generate a high precision clock signal, the precision of the high precision clock signal being higher than the ECG sampling module and the PPG The accuracy of the clock signal in the sampling module is an order of magnitude higher;
  • the processor is specifically configured to control the ECG sampling module and the PPG sampling module to simultaneously sample the standard periodic signal according to the high-precision clock signal; and record the ECG sampling module according to the high-precision clock signal And a sampling end time of the standard periodic signal by the PPG sampling module.
  • the clock module includes: a high-precision system crystal oscillator, a clock module in a Bluetooth module, and a clock module in a WiFi module;
  • the high-precision clock signal is generated by any one of a high-precision system crystal oscillator, a synchronous calibration clock signal of a Bluetooth module, and a synchronous calibration clock signal of a WiFi module;
  • the high precision clock signal includes:
  • Any one of a sine wave signal, a triangular wave signal, and a sawtooth wave signal is any one of a sine wave signal, a triangular wave signal, and a sawtooth wave signal.
  • the processor is further configured to generate the standard periodic signal according to the high precision clock signal.
  • the processor is configured to control the ECG sampling module to sample the standard periodic signal, calculate a frequency f 1 of the sampled data, and control the PPG sampling.
  • , ⁇ f 20
  • the processor is specifically configured to calculate a difference ⁇ t 21 , ⁇ t between sampling end times of the standard periodic signal by the ECG sampling module and the PPG sampling module.
  • 21
  • , t 1 is a sampling end time of the standard periodic signal by the ECG sampling module, and t 2 is a sampling end time of the standard periodic signal by the PPG sampling module;
  • ⁇ t 21 , t p2 is the PPG
  • the sampling triggering time of the sampling module, T 0 is the preset time threshold; if ⁇ t 21 >T 0 , and t 2 ⁇ t 1 , delaying the sampling triggering time t p2 of the PPG sampling module, and satisfying T 0 ⁇
  • the blood pressure detecting signal sampling compensation method and device and the blood pressure signal collecting system provided by the embodiments of the present invention, by controlling the ECG sampling module and the PPG sampling module to sample the ECG signal and the PPG signal of the user to be tested, and sampling the standard periodic signal, Obtaining the difference between the sampling end time of the ECG signal and the PPG signal, and the sampling frequency deviation of the standard periodic signal by the ECG sampling module and the PPG sampling module, thereby compensating the sampling start time of the ECG sampling module or the PPG sampling module, and sampling the ECG
  • the sampling frequency of the module and the PPG sampling module is compensated, so that the difference between the sampling end time of the ECG signal and the PPG signal is lower than the preset time threshold, and the sampling frequency deviation of the standard periodic signal by the ECG sampling module and the PPG sampling module is lower than the preset.
  • the frequency threshold such that the error of the PTT determined according to the ECG sampling module and the PPG sampling module is also within the allowable range, so that the error of the blood pressure value measured by the PTT method is within the allowable range, and the accuracy of the blood pressure measurement by the PTT method is improved.
  • Embodiment 1 is a flowchart of Embodiment 1 of a blood pressure detecting signal sampling compensation method according to an embodiment of the present invention
  • Embodiment 2 is a flowchart of Embodiment 2 of a blood pressure detecting signal sampling compensation method according to an embodiment of the present invention
  • Embodiment 3 is a flowchart of Embodiment 3 of a blood pressure detecting signal sampling compensation method according to an embodiment of the present invention
  • Embodiment 4 is a schematic structural diagram of Embodiment 1 of a blood pressure detecting signal sampling and compensating device according to an embodiment of the present invention
  • FIG. 5 is a schematic structural diagram of Embodiment 2 of a blood pressure detecting signal sampling and compensating device according to an embodiment of the present invention
  • FIG. 6 is a schematic structural diagram of Embodiment 1 of a blood pressure signal sampling system according to an embodiment of the present invention.
  • FIG. 7 is a schematic structural diagram of Embodiment 2 of a blood pressure signal sampling system according to an embodiment of the present invention.
  • the PTT method When using the PTT method to measure blood pressure, it is necessary to measure the user's ECG signal and PPG signal simultaneously.
  • PTT is obtained, and then the relationship between PTT and blood pressure is obtained, and the blood pressure values of systolic blood pressure and diastolic blood pressure are obtained.
  • the ECG signal and the PPG signal are respectively sampled by the corresponding ECG sampling module and the PPG sampling module.
  • the sampling frequency and the sampling time of the ECG sampling module and the PPG sampling module it may result in a deviation of the PTT obtained by analyzing the ECG signal and the PPG signal, which may affect the finally obtained blood pressure value.
  • an embodiment of the present invention provides a blood pressure detecting signal sampling compensation method, which compensates a signal collected by an ECG sampling module and a PPG sampling module, so that a deviation of the finally measured blood pressure value is less than a preset threshold.
  • FIG. 1 is a flowchart of Embodiment 1 of a blood pressure detecting signal sampling compensation method according to an embodiment of the present invention
  • Step S101 the ECG sampling module and the PPG sampling module are controlled to simultaneously sample the standard period signal.
  • the ECG sampling module and the PPG sampling module are independent of each other, so the sampling time and sampling frequency of the ECG sampling module and the PPG sampling module may be There is a deviation, so there will be a deviation between the time synchronization or frequency synchronization of the sampled ECG signal and the PPG signal, which leads to errors in the PTT. Therefore, to solve the PTT error, it is necessary to eliminate the sampling time deviation and sampling frequency deviation of the ECG sampling module and the PPG sampling module.
  • the sampling time deviation and sampling frequency deviation of the ECG sampling module and the PPG sampling module we must first measure the sampling time deviation and sampling frequency deviation of the ECG sampling module and the PPG sampling module, so as to compensate the sampling time and sampling frequency of the ECG sampling module and the PPG sampling module, so that the PTT error is reduced to the allowable range. Further, the error of the blood pressure value measured by the PTT method is within an allowable range.
  • the ECG sampling module and the PPG sampling module can be respectively controlled to simultaneously sample a standard period signal.
  • Step S102 obtaining a sampling frequency and a sampling end time of the standard period signal by the ECG sampling module and the PPG sampling module, respectively.
  • the ECG sampling module and the PPG sampling module are separately controlled to simultaneously sample the standard period signal, the sampling frequencies of the signals sampled by the ECG sampling module and the PPG sampling module are respectively recorded, and the sampling end time is separately recorded.
  • Controlling the ECG sampling module and the PPG sampling module to simultaneously sample can be implemented by using a timer, and the controller sends a sampling notification message to the ECG sampling module and the PPG sampling module according to the trigger of the timer, so that the ECG sampling module and the PPG sampling are performed.
  • the module implements simultaneous measurements. Since the PTT needs to be synchronously compared by the signals collected by the ECG sampling module and the PPG sampling module, the data amount or sampling time of the sampling by the ECG sampling module and the PPG sampling module should be the same.
  • the ECG sampling module and the PPG sampling module may have sampling errors, although the ECG sampling module and the PPG sampling module start sampling at the same time, the sampling end time may be different, so the sampling of the ECG sampling module and the PPG sampling module respectively ends. Time to record.
  • a known reference signal is used to measure the sampling frequency of the known reference signal by the ECG sampling module and the PPG sampling module, and the sampling frequency error of the ECG sampling module and the PPG sampling module can be known.
  • the ECG sampling module and the PPG sampling module are separately controlled to sample a standard period signal, which is a standard sine wave, square wave, triangle wave, sawtooth wave, etc., and the frequency is known and stable.
  • the standard period signal can use an existing one-cycle signal, or it can be a newly generated one-cycle signal.
  • Step S103 if the sampling frequency deviation of the standard periodic signal exceeds the preset frequency threshold by the ECG sampling module, the sampling frequency of the ECG sampling module is compensated, so that the sampling frequency deviation of the standard periodic signal by the ECG sampling module is lower than the preset frequency. Threshold.
  • the sampled data can be separately obtained, and after the two sampled data are separately analyzed, the frequency of the sampled data can be obtained.
  • the sampling frequency deviation of the standard period signal by the ECG sampling module and the PPG sampling module can be separately calculated.
  • the error of sampling the standard periodic signal reflects the systematic sampling error of the ECG sampling module and the PPG sampling module.
  • the sampling error of the ECG sampling module and the PPG sampling module can be eliminated.
  • the sampling frequency deviation of the standard periodic signal by the ECG sampling module After calculating the sampling frequency deviation of the standard periodic signal by the ECG sampling module, if the sampling frequency deviation of the standard periodic signal by the ECG sampling module does not exceed the preset frequency threshold, it means that the sampling frequency deviation of the ECG sampling module is within the allowable range. No compensation is required.
  • the purpose of compensating the ECG sampling module is to make the sampling frequency deviation of the ECG sampling module to the standard period signal lower than the preset frequency threshold.
  • the compensation method for the ECG sampling module is to increase or decrease the number of sampling points sampled by the ECG sampling module, thereby increasing or decreasing the sampling frequency of the ECG sampling module.
  • Step S104 If the sampling frequency deviation of the standard period signal exceeds the preset frequency threshold by the PPG sampling module, the sampling frequency of the PPG sampling module is compensated, so that the sampling frequency deviation of the PPG sampling module from the standard periodic signal is lower than the pre-predetermined Set the frequency threshold.
  • the sampling frequency deviation of the PPG sampling module for the standard period signal does not exceed the preset frequency threshold, which means that the sampling frequency deviation of the PPG sampling module is within the allowable range and no compensation is needed.
  • the purpose of compensating the PPG sampling module is to make the sampling frequency deviation of the PPG sampling module from the standard period signal lower than the preset frequency threshold.
  • the compensation method for the PPG sampling module is to increase or decrease the number of sampling points sampled by the PPG sampling module, thereby increasing or decreasing the sampling frequency of the PPG sampling module.
  • the sampling frequency of the compensated ECG sampling module and the sampling frequency of the PPG signal are used as the new sampling frequency of the ECG sampling module and the PPG sampling module. This eliminates the impact of the sampling frequency deviation of the ECG sampling module and the PPG sampling module on the calculation of the PTT.
  • Step S105 if the difference between the sampling end time of the standard periodic signal of the ECG sampling module and the PPG sampling module exceeds the preset time threshold, the sampling start time of the ECG sampling module or the PPG sampling module is compensated, so that the ECG sampling module and the PPG The difference between the sampling end time of the sampling module for the standard period signal is lower than the preset time threshold.
  • the preset time threshold is an error range of the allowable deviation, and can be determined according to different precision requirements for blood pressure measurement. For example, in a home level blood pressure measurement, the preset time threshold can be set relatively large, and the blood pressure at the medical level. In the measurement, the preset time threshold needs to be set relatively small. If the difference between the sampling end time of the standard period signal of the ECG sampling module and the PPG sampling module does not exceed the preset time threshold, it means that the sampling time deviation of the ECG sampling module and the PPG sampling module is within the allowable range, and no compensation is needed.
  • the sampling time deviation of the ECG sampling module and the PPG sampling module exceeds the allowable range, and needs to be compensated.
  • the compensation may be to compensate the ECG sampling module, or to compensate the PPG sampling module, which may be the starting sampling time of the delayed ECG sampling module or the PPG sampling module, or may be the starting sampling of the advanced ECG sampling module or the PPG sampling module. time. But generally, it is the start sampling time of the delayed ECG sampling module or the PPG sampling module.
  • the difference between the sampling end time of the ECG sampling module and the PPG sampling module for the standard period signal is lower than the preset time threshold, and the start sampling time of the compensated ECG sampling module and the sampling start time of the PPG signal are used as the ECG sampling module. And the new start sampling of the PPG sampling module between. This eliminates the impact of the time deviation of the ECG sampling module and the PPG sampling module on the calculation of the PTT.
  • the blood pressure detecting signal sampling compensation method samples the standard periodic signal by controlling the ECG sampling module and the PPG sampling module to obtain the sampling frequency and the sampling end time of the standard periodic signal of the ECG sampling module and the PPG sampling module, respectively. Therefore, the sampling start time of the ECG sampling module or the PPG sampling module is compensated, and the sampling frequency of the ECG sampling module and the PPG sampling module is compensated, so that the difference between the sampling end time of the ECG sampling module and the PPG sampling module for the standard periodic signal is obtained.
  • the sampling frequency deviation of the ECG sampling module and the PPG sampling module for the standard periodic signal is lower than the preset frequency threshold, so that the error of the PTT determined according to the ECG sampling module and the PPG sampling module is also within the allowable range, so that The error of the blood pressure value measured by the PTT method is within the allowable range, and the accuracy of the blood pressure measurement by the PTT method is improved.
  • a high-precision clock signal is required as the basis for time synchronization and as a basis for generating a standard period signal. Then, before sampling the standard period signal, a high-precision clock signal can be generated.
  • the accuracy of the high-precision clock signal is one order of magnitude higher than the accuracy of the clock signal in the ECG sampling module and the PPG sampling module.
  • the high-precision clock signal ensures accurate recording of the start sampling time and sampling end time of the ECG sampling module and the PPG sampling module, as well as ensuring the frequency stability of the standard periodic signal generated based on the high-precision clock signal.
  • the high-precision clock signal is generated by any one of a high-precision system crystal oscillator, a synchronous calibration clock signal of the Bluetooth module, and a synchronous calibration clock signal of a Wireless Fidelity (WiFi) module.
  • the high-precision clock signal includes any one of a sine wave signal, a triangular wave signal, and a sawtooth wave signal.
  • Embodiment 2 is a flowchart of Embodiment 2 of a blood pressure detection signal sampling compensation method according to an embodiment of the present invention. As shown in FIG. 2, the method provided in this embodiment includes:
  • Step S201 the ECG sampling module is controlled to sample the standard period signal, and the frequency f 1 of the sampled data is calculated.
  • Step S202 the PPG sampling module is controlled to sample the standard period signal, and the frequency f 2 of the sampled data is calculated.
  • the blood pressure detecting signal sampling compensation method is a specific method for compensating for the frequency error of the blood pressure detecting signal.
  • the control ECG sampling module samples the standard period signal to obtain a plurality of sampled data. Then, the frequency of the sampled signal is determined according to the obtained plurality of sample data, and is denoted as f 1 .
  • the PPG sampling module is controlled to sample the standard period signal to obtain a plurality of sampling data. Then, the frequency of the sampled signal is determined according to the obtained plurality of sample data, and is denoted as f 2 .
  • the standard period signal is any one of a sine wave signal, a triangular wave signal, a square wave signal, and a sawtooth wave signal having a fixed frequency.
  • the method of sampling the frequency of the standard periodic signal may be to use the maximum value method or the minimum value method to extract the peak values of the acquired K data to calculate the frequency of each data. Then, the frequency of K data of K cycles is averaged to obtain f1. Similarly, f 2 can be obtained according to the above method.
  • , ⁇ f 20
  • , ⁇ f 20
  • f 0 is the frequency of the standard periodic signal.
  • ⁇ f 10 is the sampling frequency deviation of the ECG sampling module for the standard period signal
  • ⁇ f 20 is the sampling frequency deviation of the PPG sampling module for the standard period signal.
  • Step S204 determining whether the sampling frequency deviation of the standard period signal by the ECG sampling module exceeds a preset frequency threshold.
  • ⁇ f 10 and F 0 it is determined whether the sampling frequency deviation of the standard period signal by the ECG sampling module exceeds a preset frequency threshold, where F 0 is a preset frequency threshold. If ⁇ f 10 ⁇ F 0 , it means that the sampling frequency deviation of the ECG sampling module for the standard period signal does not exceed the preset frequency threshold, then the sampling frequency of the ECG sampling module does not need to be compensated, and the process can be ended. If ⁇ f 10 >F 0 , it is necessary to judge the relationship between f 1 and f 0 . If f 1 >f 0 , step S205 is performed, and if f 1 ⁇ f 0 , step S206 is performed.
  • Step S205 if ⁇ f 10 >F 0 , and f 1 >f 0 , reduce the number L of data sampled by the ECG sampling module, ( ⁇ f 10 -F 0 ) ⁇ L ⁇ f 10 , (F 1 -L) as the new sampling frequency of the ECG sampling module, where F 1 is the original sampling frequency of the ECG sampling module and F 0 is the preset frequency threshold.
  • the method for reducing the sampling frequency of the ECG sampling module may be to reduce the number L of data sampled by the ECG sampling module, wherein ( ⁇ f 10 -F 0 ) ⁇ L ⁇ ⁇ f 10 , thereby ensuring new sampling of the ECG sampling module
  • the sampling frequency deviation of the frequency (F 1 -L) can meet the demand.
  • F 1 is the original sampling frequency of the ECG sampling module.
  • Step S206 if ⁇ f 10 >F 0 , and f 1 ⁇ f 0 , increase the number M of data sampled by the ECG sampling module, ( ⁇ f 10 -F 0 ) ⁇ M ⁇ ⁇ f 10 , (F 1 +M) As the new sampling frequency of the ECG sampling module.
  • the method for increasing the sampling frequency of the ECG sampling module may be to increase the number M of data to be sampled by the ECG sampling module, wherein ( ⁇ f 10 -F 0 ) ⁇ M ⁇ ⁇ f 10 , thereby ensuring the new ECG sampling module
  • the sampling frequency deviation of the sampling frequency (F 1 +M) can meet the demand.
  • Step S207 determining whether the sampling frequency deviation of the standard period signal by the PPG sampling module exceeds a preset frequency threshold.
  • ⁇ f 20 and F 0 it is determined whether the sampling frequency deviation of the standard period signal by the PPG sampling module exceeds a preset frequency threshold. If ⁇ f 20 ⁇ F 0 , it means that the sampling frequency deviation of the PPG sampling module for the standard period signal does not exceed the preset frequency threshold, then the sampling frequency of the PPG sampling module does not need to be compensated, and the process can be ended. If ⁇ f 20 > F 0 , it is necessary to judge the relationship between f 2 and f 0 . If f 2 > f 0 , step S208 is performed, and if f 2 < f 0 , step S209 is executed.
  • Step S208 if ⁇ f 20 >F 0 , and f 2 >f 0 , reduce the number N of data sampled by the PPG sampling module, ( ⁇ f 20 -F 0 ) ⁇ N ⁇ f 20 , (F 2 -N) as the new sampling frequency of the PPG sampling module, where F 2 is the original sampling frequency of the PPG sampling module.
  • the method for reducing the sampling frequency of the PPG sampling module may be to reduce the number N of data sampled by the PPG sampling module, wherein ( ⁇ f 20 -F 0 ) ⁇ N ⁇ ⁇ f 20 , thereby ensuring new sampling of the PPG sampling module
  • the sampling frequency deviation of the frequency (F 2 -N) can meet the demand. Where F 2 is the original sampling frequency of the PPG sampling module.
  • Step S209 if ⁇ f 20 >F 0 , and f 2 ⁇ f 0 , increase the number of data P to be sampled by the PPG sampling module, ( ⁇ f 20 -F 0 ) ⁇ P ⁇ ⁇ f 20 , (F 2 +P) as the new sampling frequency of the PPG sampling module.
  • the sampling frequency of the PPG sampling module needs to be increased.
  • the method for increasing the sampling frequency of the PPG sampling module may be to increase the number of data P sampled by the PPG sampling module, wherein ( ⁇ f 20 -F 0 ) ⁇ P ⁇ ⁇ f 20 , thereby ensuring new sampling of the PPG sampling module
  • the sampling frequency deviation of the frequency (F 2 + P) can meet the demand.
  • FIG. 3 is a flowchart of Embodiment 3 of a method for compensating a blood pressure detection signal according to an embodiment of the present invention. As shown in FIG. 3, the method provided in this embodiment includes:
  • Step S301 the ECG sampling module and the PPG sampling module are controlled to simultaneously sample the standard period signal, and the sampling end time is separately recorded.
  • a timer may be set, which may trigger a sampling trigger signal, and simultaneously control the ECG sampling module and the PPG sampling module to sample the standard period signal when the timer expires. ECG were recorded and samples of the sampling module and the end time t sampling a sampling module PPG end time t 2.
  • Step S303 determining that the ECG sampling module and the PPG sampling module sample the standard period signal Whether the difference in end time exceeds the preset time threshold.
  • ⁇ t 21 and T 0 it is determined whether the difference between the sampling end time of the standard period signal of the ECG sampling module and the PPG sampling module exceeds a preset time threshold, where T 0 is a preset time threshold. If ⁇ t 21 ⁇ T 0 , it means that the difference between the sampling end time of the ECG sampling module and the PPG sampling module for the standard period signal does not exceed the preset time threshold, so there is no need to compensate the sampling time of the ECG sampling module and the PPG sampling module. This process can be ended. If ⁇ t 21 > T 0 , it is necessary to judge the relationship before t 2 and t 1 . If t 2 &gt ; t 1 , step S304 is performed, and if t 2 < t 1 , step S305 is performed.
  • Step S304 if ⁇ t 21 >T 0 , and t 2 >t 1 , delay the sampling trigger time t p1 of the ECG sampling module, and satisfy T 0 ⁇
  • ⁇ t 21 >T 0 it means that the difference between the sampling end time of the ECG sampling module and the PPG sampling module for the standard period signal exceeds the preset time threshold, and t 2 >t 1 represents the sampling end time of the PPG sampling module.
  • the sampling start time t p1 of the ECG sampling module needs to be delayed, and T 0 ⁇
  • the sampling time of the PPG sampling module can be advanced to compensate the sampling time.
  • Step S305 if ⁇ t 21 >T 0 and t 2 ⁇ t 1 , delay the sampling trigger time t p2 of the PPG sampling module, and satisfy T 0 ⁇
  • ⁇ t 21 >T 0 it means that the difference between the sampling end time of the ECG sampling module and the PPG sampling module for the standard period signal exceeds the preset time threshold, and t 2 ⁇ t 1 represents the sampling end time of the PPG sampling module.
  • t p2 of the PPG sampling module Before the adoption end time of the ECG sampling module, it is necessary to delay the sampling start time t p2 of the PPG sampling module and satisfy T 0 ⁇
  • the sampling time of the ECG sampling module can be advanced to compensate the sampling time.
  • FIG. 4 is a schematic structural diagram of Embodiment 1 of a blood pressure detecting signal sampling and compensating device according to an embodiment of the present invention, as shown in FIG. 4, the blood pressure detecting signal sampling and compensating device provided by the present embodiment includes:
  • the control module 41 is configured to control the ECG sampling module and the PPG module to simultaneously sample the standard period signal.
  • the calculating module 42 is configured to obtain a sampling frequency and a sampling end time of the standard period signal by the ECG sampling module and the PPG sampling module, respectively.
  • the compensation module 43 is configured to: if the ECG sampling module samples the standard periodic signal If the rate deviation exceeds the preset frequency threshold, the sampling frequency of the ECG sampling module is compensated, so that the sampling frequency deviation of the standard periodic signal by the ECG sampling module is lower than a preset frequency threshold; if the PPG sampling If the sampling frequency deviation of the standard periodic signal exceeds the preset frequency threshold, the sampling frequency of the PPG sampling module is compensated, so that the sampling frequency deviation of the PPG sampling module for the standard periodic signal is lower than the pre-pre Setting a frequency threshold; if the difference between the sampling end time of the standard periodic signal by the ECG sampling module and the PPG sampling module exceeds a preset time threshold, sampling of the ECG sampling module or the PPG sampling module begins The time is compensated such that the difference between the sampling end time of the ECG sampling module and the PPG sampling module for the standard period signal is lower than a preset time threshold.
  • the blood pressure detecting signal sampling and compensating device provided in this embodiment is used to implement the method steps of the blood pressure detecting signal sampling and compensating method shown in FIG. 1 , and the implementation principle and the technical effect thereof are similar, and details are not described herein again.
  • FIG. 5 is a schematic structural diagram of Embodiment 2 of a blood pressure detecting signal sampling and compensating apparatus according to an embodiment of the present invention. As shown in FIG. 5, the blood pressure detecting signal sampling and compensating apparatus provided in this embodiment further includes:
  • the clock module 51 is configured to generate a high precision clock signal, the precision of the high precision clock signal being one order of magnitude higher than the accuracy of the clock signal in the ECG sampling module and the PPG sampling module.
  • the control module 41 is configured to control, according to the high-precision clock signal, the ECG sampling module and the PPG sampling module to simultaneously sample the standard periodic signal; and record the ECG sampling module according to the high-precision clock signal and The sampling end time of the standard period signal by the PPG sampling module.
  • the high-precision clock signal is generated by any one of a high-precision system crystal oscillator, a synchronous calibration clock signal of a Bluetooth module, and a synchronous calibration clock signal of a WiFi module;
  • the clock signal includes any one of a sine wave signal, a triangular wave signal, and a sawtooth wave signal.
  • the calculation module 42 is further configured to generate the standard period signal according to the high precision clock signal.
  • control module 41 is specifically configured to control the ECG sampling module to sample the standard periodic signal, calculate a frequency f 1 of the sampled data, and control the The PPG sampling module samples the standard periodic signal and calculates the frequency f 2 of the sampled data.
  • , ⁇ f 20
  • the compensation module 43 is specifically configured to reduce the number L of data sampled by the ECG sampling module if ⁇ f 10 >F 0 and f 1 >f 0 , ( ⁇ f 10 -F 0 ) ⁇ L ⁇ f 10 , using (F 1 -L) as a new sampling frequency of the ECG sampling module, where F 1 is the original sampling frequency of the ECG sampling module, and F 0 is a preset frequency threshold; if ⁇ f 10 >F 0 And f 1 ⁇ f 0 , increasing the number M of data sampled by the ECG sampling module, ( ⁇ f 10 -F 0 ) ⁇ M ⁇ f 10 , using (F 1 +M) as the ECG sampling The new sampling frequency of the module; if ⁇ f 20 >F 0 and f 2 >f 0 , reduce the number N of data sampled by the PPG sampling module, ( ⁇ f 20 -F 0 ) ⁇ N ⁇ f 20 , using (F 2 -N) as a new sampling frequency of the PPG sampling
  • , t 1 is a sampling end time of the standard period signal by the ECG sampling module, and t 2 is a sampling end time of the standard period signal by the PPG sampling module.
  • the compensation module 43 is specifically configured to delay the sampling trigger time t p1 of the ECG sampling module if ⁇ t 21 >T 0 and t 2 >t 1 , and satisfy T 0 ⁇
  • FIG. 6 is a schematic structural diagram of Embodiment 1 of a blood pressure signal sampling system according to an embodiment of the present invention.
  • the blood pressure signal sampling system provided in this embodiment includes: an ECG sampling module 61, a PPG sampling module 62, and a processor 63. .
  • the processor 63 is configured to control the ECG sampling module 61 and the PPG module 62 to simultaneously sample the standard period signal; respectively obtain the sampling frequency and the sampling end time of the standard period signal by the ECG sampling module 61 and the PPG sampling module 62; if the ECG sampling If the sampling frequency deviation of the standard period signal exceeds the preset frequency threshold, the sampling frequency of the ECG sampling module 61 is compensated, so that the sampling frequency deviation of the standard periodic signal by the ECG sampling module 61 is lower than the preset.
  • Frequency threshold if the sampling frequency deviation of the standard period signal by the PPG sampling module 62 exceeds The preset frequency threshold is used to compensate the sampling frequency of the PPG sampling module 62, so that the sampling frequency deviation of the standard periodic signal by the PPG sampling module 62 is lower than the preset frequency threshold; if the ECG sampling module 61 and the PPG sampling module 62 If the difference between the sampling end times of the standard period signals exceeds the preset time threshold, the sampling start time of the ECG sampling module 61 or the PPG sampling module 62 is compensated, so that the ECG sampling module 61 and the PPG sampling module 62 The difference between the sampling end times of the standard period signals is lower than the preset time threshold.
  • the blood pressure signal sampling system may be any system capable of performing blood pressure detection according to the PTT method.
  • it may be a wrist blood pressure detector for home use, an arm blood pressure detector, or any blood pressure detector that can be medical.
  • It includes an ECG sampling module 61 and a PPG sampling module 62.
  • the ECG sampling module 61 is configured to collect an ECG signal of the user, and is composed of an ECG sensor and an ECG signal sampling chip, and can adopt an integrated analog front end chip (for example, ADS1292) or a discrete sampling chip.
  • the PPG sampling module 62 is composed of a PPG optical sensor and a PPG sampling chip, and can be an integrated analog front end chip (for example, AFE4404/ADPD153) or a discrete sampling chip.
  • Processor 63 can be any hardware chip with processing functionality.
  • FIG. 7 is a schematic structural diagram of Embodiment 2 of a blood pressure signal sampling system according to an embodiment of the present invention. As shown in FIG. 7, the blood pressure signal sampling system provided in this embodiment further includes FIG.
  • the clock module 71 is configured to generate a high-precision clock signal whose accuracy is one order of magnitude higher than the accuracy of the clock signal in the ECG sampling module 61 and the PPG sampling module 62.
  • the processor 63 is configured to control the ECG sampling module 61 and the PPG sampling module 62 to simultaneously sample the standard periodic signal according to the high-precision clock signal; and record the ECG sampling module 61 and the PPG sampling module 62 according to the high-precision clock signal. The sampling end time of the standard period signal.
  • the clock module 71 can be any one of a high precision system crystal oscillator, a clock module in a Bluetooth module, and a clock module in a wireless fidelity WiFi module.
  • the high-precision clock signal includes any one of a sine wave signal, a triangular wave signal, and a sawtooth wave signal.
  • the processor 63 is further configured to generate the standard period signal according to the high precision clock signal.
  • the processor 63 is specifically configured to control the ECG sampling module 61 to sample the standard periodic signal, calculate the frequency f 1 of the sampled data, and control the PPG sampling module.
  • , ⁇ f 20
  • F 1 is the original sampling frequency of the ECG sampling module 61
  • F 0 is a preset frequency threshold
  • the number of data to be sampled M ( ⁇ f 10 -F 0 ) ⁇ M ⁇ ⁇ f 10 , and (F 1 + M) is taken as the new sampling frequency of the ECG sampling module 61; if ⁇ f 2 0 > F 0 and f 2 > f 0 , the number N of data sampled by the PPG sampling module 61 is reduced, ( ⁇ f 20 -F 0 ) ⁇ N ⁇ ⁇ f 20 , and (F 2 -N) is used as the PPG.
  • the new sampling frequency of the sampling module 62 where F 2 is the original sampling frequency of the PPG sampling module 62; if ⁇ f 20 >F 0 and f 2 ⁇ f 0 , the number of data to be sampled by the PPG sampling module 62 is increased. ( ⁇ f 20 -F 0 ) ⁇ P ⁇ ⁇ f 20 , (F 2 + P) is taken as the new sampling frequency of the PPG sampling module 62.
  • the processor 63 is specifically configured to calculate a difference ⁇ t 21 , ⁇ t between the sampling end times of the standard periodic signals by the ECG sampling module 61 and the PPG sampling module 62.
  • 21
  • , t 1 is a sampling end time of the standard period signal by the ECG sampling module 61, and t 2 is a sampling end time of the standard period letter by the PPG sampling module 62; If ⁇ t 21 >T 0 and t 2 >t 1 , the sampling trigger time t p1 of the ECG sampling module 61 is delayed, and T 0 ⁇
  • the sampling trigger time of the module 62, T 0 is the preset time threshold; if ⁇ t 21 >T 0 , and t 2 ⁇ t 1 , the sampling trigger time t p2 of the PPG sampling module 62 is delayed, and T 0 ⁇
  • the aforementioned program can be stored in a computer readable storage medium.
  • the program when executed, performs the steps including the foregoing method embodiments; and the foregoing storage medium includes various media that can store program codes, such as a ROM, a RAM, a magnetic disk, or an optical disk.

Abstract

一种血压检测信号采样补偿方法和装置以及血压信号采集系统，该方法包括：控制ECG采样模块（61）和PPG采样模块（62）同时对标准周期信号进行采样，分别采样频率和采样结束时间；对ECG采样模块（61）或PPG采样模块（62）的采样开始时间和采样频率进行补偿，使采样频率偏差低于预设频率阈值且采样结束时间之差低于预设时间阈值。

Description

血压检测信号采样补偿方法和装置以及血压信号采集系统 技术领域
本发明实施例涉及血压检测技术领域，尤其涉及一种血压检测信号采样补偿方法和装置以及血压信号采集系统。
背景技术
血压(Blood Pressure，BP)是血液在血管内流动时，作用于单位面积血管壁的侧压力，即压强。血压是反应人体心脏和血管功能的重要生理指标，在疾病诊断、质量效果观察和进行预后判断等方面都具有重要的意义。
近年来，随着智能终端、可穿戴设备以及移动医疗技术的快速发展，血压监测的便捷性逐渐提升，从而人们越来越重视家庭血压和动态血压的监测。
许多研究表明，脉搏沿动脉传播的速率-脉搏波速度(Pulse Wave Velocity，PWV)与动脉血压之间具有正相关性。一种常用的PWV测量方法是计算脉搏波传输时间(Pulse Transit Time，PTT)，也就是脉搏波从心脏传动至动脉上某一点所需的时间。利用PTT测量血压无需被测者使用袖带，不会对测量装置下的组织或血管造成任何损伤，能够为用户提供一种便捷和舒适的血压测量方式，而且结构可以小巧轻便，适合于随身携带或可穿戴产品的应用。
PTT的测量方法基本都采用同步采集心电图(electrocardiogram，ECG)信号和光电容积描记图(Photoplethysmography，PPG)信号，识别ECG信号的R波与PPG信号的最大值点，得到延迟时间PTT。通过建立PTT与血压之间的数学模型关系，最终得到收缩压和舒张压的血压值。由于对ECG信号和PPG信号的采样是分别进行的，采样的时间和频率精度可能存在偏差。而采样的偏差将直接影响后续血压数学建模的精度，从而影响采用PWV方法对血压测量的精确度。
发明内容
本发明实施例提供一种血压检测信号采样补偿方法和装置以及血压信号 采集系统，用于提高血压检测信号的精度。
第一方面提供一种血压检测信号采样补偿方法，包括；
控制ECG采样模块和PPG模块同时对标准周期信号进行采样；
分别获得所述ECG采样模块和所述PPG采样模块对所述标准周期信号的采样频率和采样结束时间；
若所述ECG采样模块对所述标准周期信号的采样频率偏差超过预设频率阈值，则对所述ECG采样模块的采样频率进行补偿，以使所述ECG采样模块对所述标准周期信号的采样频率偏差低于预设频率阈值；
若所述PPG采样模块对所述标准周期信号的采样频率偏差超过预设频率阈值，则对所述PPG采样模块的采样频率进行补偿，以使所述PPG采样模块对所述标准周期信号的采样频率偏差低于预设频率阈值；
若所述ECG采样模块和所述PPG采样模块对所述标准周期信的采样结束时间之差超过预设时间阈值，则对所述ECG采样模块或所述PPG采样模块的采样开始时间进行补偿，以使所述ECG采样模块和所述PPG采样模块对所述标准周期信号的采样结束时间之差低于预设时间阈值。
本发明提供的血压检测信号采样补偿方法，通过控制ECG采样模块和PPG采样模块对待测用户的ECG信号和PPG信号进行采样，以及对标准周期信号进行采样，以获取ECG信号和PPG信号的采样结束时间之差，以及ECG采样模块和PPG采样模块对标准周期信号的采样频率偏差，从而对ECG采样模块或PPG采样模块的采样开始时间进行补偿，以及对ECG采样模块和PPG采样模块的采样频率进行补偿，从而使ECG信号和PPG信号的采样结束时间之差低于预设时间阈值，ECG采样模块和PPG采样模块对标准周期信号的采样频率偏差低于预设频率阈值，如此根据ECG采样模块和PPG采样模块确定的PTT的误差也在允许范围内，使得通过PTT方法测量出的血压值的误差在允许范围内，提高了通过PTT方法对血压测量的精度。
在第一方面一种可能的实现方式中，所述控制ECG采样模块和PPG采样模块同时对标准周期信号进行采样之前，还包括：
生成高精度时钟信号，所述高精度时钟信号的精度比所述ECG采样模块和所述PPG采样模块中的时钟信号的精度高一个数量级；
所述控制ECG采样模块和PPG采样模块同时对标准周期信号进行采样， 包括：
根据所述高精度时钟信号控制所述ECG采样模块和所述PPG采样模块同时对所述标准周期信号进行采样；
所述分别获得所述ECG采样模块和所述PPG采样模块对所述标准周期信号的采样频率和采样结束时间，包括：
根据所述高精度时钟信号记录所述ECG采样模块和所述PPG采样模块对所述标准周期信号的采样结束时间。
高精度的时钟信号能够保证对ECG采样模块和PPG采样模块的开始采样时间和采样结束时间的精确记录，以及保证根据高精度时钟信号生成的标准周期信号频率稳定。
在第一方面一种可能的实现方式中，所述高精度时钟信号由高精度系统晶振、蓝牙模块的同步校准时钟信号、WiFi模块的同步校准时钟信号中的任一种生成；
所述高精度时钟信号包括：
正弦波信号、三角波信号、锯齿波信号中的任一种。
在第一方面一种可能的实现方式中，所述控制ECG采样模块和PPG采样模块分别对标准周期信号进行采样之前，还包括：
根据所述高精度时钟信号生成所述标准周期信号。
在第一方面一种可能的实现方式中，所述控制ECG采样模块和PPG采样模块分别对标准周期信号进行采样，包括：
控制所述ECG采样模块对所述标准周期信号进行采样，计算采样后的数据的频率f1；
控制所述PPG采样模块对所述标准周期信号进行采样，计算采样后的数据的频率f2；
所述分别获得所述ECG采样模块和所述PPG采样模块对所述标准周期信号的采样频率和采样结束时间，包括：
计算△f10＝|f1-f0|，△f20＝|f2-f0|，其中f0为所述标准周期信号的频率，△f10为所述ECG采样模块对所述标准周期信号的采样频率偏差，△f20为所述PPG采样模块对所述标准周期信号的采样频率偏差；
所述若所述ECG采样模块对所述标准周期信号的采样频率偏差超过预 设频率阈值，则对所述ECG采样模块的采样频率进行补偿，以使所述ECG采样模块对所述标准周期信号的采样频率偏差低于预设频率阈值，包括：
若△f10>F0，且f1>f0，则减少所述ECG采样模块进行采样的数据个数L，(△f10-F0)≤L≤△f10，将(F1-L)作为所述ECG采样模块的新的采样频率，其中F1为所述ECG采样模块的原始采样频率，F0为预设频率阈值；
若△f10>F0，且f1<f0，则增加所述ECG采样模块进行采样的数据个数M，(△f10-F0)≤M≤△f10，将(F1+M)作为所述ECG采样模块的新的采样频率；
所述若所述PPG采样模块对所述标准周期信号的采样频率偏差超过预设频率阈值，则对所述PPG采样模块的采样频率进行补偿，以使所述PPG采样模块对所述标准周期信号的采样频率偏差低于预设频率阈值，包括：
若△f20>F0，且f2>f0，则减少所述PPG采样模块进行采样的数据个数N，(△f20-F0)≤N≤△f20，将(F2-N)作为所述PPG采样模块的新的采样频率，其中F2为所述PPG采样模块的原始采样频率；
若△f20>F0，且f2<f0，则增加所述PPG采样模块进行采样的数据个数P，(△f20-F0)≤P≤△f20，将(F2+P)作为所述PPG采样模块的新的采样频率。
在第一方面一种可能的实现方式中，所述若所述ECG采样模块和所述PPG采样模块对所述标准周期信的采样结束时间之差超过预设时间阈值，则对所述ECG采样模块或所述PPG采样模块的采样开始时间进行补偿，以使所述ECG采样模块和所述PPG采样模块对所述标准周期信号的采样结束时间之差低于预设时间阈值，包括：
计算所述ECG采样模块和所述PPG采样模块对所述标准周期信的采样结束时间之差△t21，△t21＝|t2-t1|，t1为所述ECG采样模块对所述标准周期信的采样结束时间，t2为所述PPG采样模块对所述标准周期信的采样结束时间；
若△t21>T0，且t2>t1，则延迟所述ECG采样模块的采样触发时间tp1，且满足T0<|tp1-tp2|<△t21，tp2为所述PPG采样模块的采样触发时间，T0为所述预设时间阈值；
若△t21>T0，且t2<t1，则延迟所述PPG采样模块的采样触发时间tp2，且满足T0<|tp1-tp2|<△t21。
第二方面提供一种血压检测信号采样补偿装置，包括；
控制模块，用于控制ECG采样模块和PPG模块同时对标准周期信号进 行采样；
计算模块，用于分别获得所述ECG采样模块和所述PPG采样模块对所述标准周期信号的采样频率和采样结束时间；
补偿模块，用于若所述ECG采样模块对所述标准周期信号的采样频率偏差超过预设频率阈值，则对所述ECG采样模块的采样频率进行补偿，以使所述ECG采样模块对所述标准周期信号的采样频率偏差低于预设频率阈值；若所述PPG采样模块对所述标准周期信号的采样频率偏差超过预设频率阈值，则对所述PPG采样模块的采样频率进行补偿，以使所述PPG采样模块对所述标准周期信号的采样频率偏差低于预设频率阈值；若所述ECG采样模块和所述PPG采样模块对所述标准周期信的采样结束时间之差超过预设时间阈值，则对所述ECG采样模块或所述PPG采样模块的采样开始时间进行补偿，以使所述ECG采样模块和所述PPG采样模块对所述标准周期信号的采样结束时间之差低于预设时间阈值。
在第二方面一种可能的实现方式中，所述血压检测信号采样补偿装置还包括：时钟模块，用于生成高精度时钟信号，所述高精度时钟信号的精度比所述ECG采样模块和所述PPG采样模块中的时钟信号的精度高一个数量级；
所述控制模块，具体用于根据所述高精度时钟信号控制所述ECG采样模块和所述PPG采样模块同时对所述标准周期信号进行采样；根据所述高精度时钟信号记录所述ECG采样模块和所述PPG采样模块对所述标准周期信号的采样结束时间。
在第二方面一种可能的实现方式中，所述高精度时钟信号由高精度系统晶振、蓝牙模块的同步校准时钟信号、WiFi模块的同步校准时钟信号中的任一种生成；
所述高精度时钟信号包括：
正弦波信号、三角波信号、锯齿波信号中的任一种。
在第二方面一种可能的实现方式中，所述计算模块，还用于根据所述高精度时钟信号生成所述标准周期信号。
在第二方面一种可能的实现方式中，所述控制模块，具体用于控制所述ECG采样模块对所述标准周期信号进行采样，计算采样后的数据的频率f1；控制所述PPG采样模块对所述标准周期信号进行采样，计算采样后的数据的 频率f2；
所述计算模块，具体用于计算△f10＝|f1-f0|，△f20＝|f2-f0|，其中f0为所述标准周期信号的频率，△f10为所述ECG采样模块对所述标准周期信号的采样频率偏差，△f20为所述PPG采样模块对所述标准周期信号的采样频率偏差；
所述补偿模块，具体用于若△f10>F0，且f1>f0，则减少所述ECG采样模块进行采样的数据个数L，(△f10-F0)≤L≤△f10，将(F1-L)作为所述ECG采样模块的新的采样频率，其中F1为所述ECG采样模块的原始采样频率，F0为预设频率阈值；若△f10>F0，且f1<f0，则增加所述ECG采样模块进行采样的数据个数M，(△f10-F0)≤M≤△f10，将(F1+M)作为所述ECG采样模块的新的采样频率；若△f20>F0，且f2>f0，则减少所述PPG采样模块进行采样的数据个数N，(△f20-F0)≤N≤△f20，将(F2-N)作为所述PPG采样模块的新的采样频率，其中F2为所述PPG采样模块的原始采样频率；若△f20>F0，且f2<f0，则增加所述PPG采样模块进行采样的数据个数P，(△f20-F0)≤P≤△f20，将(F2+P)作为所述PPG采样模块的新的采样频率。
在第二方面一种可能的实现方式中，所述计算模块，还用于计算所述采样模块和所述PPG采样模块对所述标准周期信的采样结束时间之差△t21，△t21＝|t2-t1|，t1为所述ECG采样模块对所述标准周期信的采样结束时间，t2为所述PPG采样模块对所述标准周期信的采样结束时间；
所述补偿模块，具体用于若△t21>T0，且t2>t1，则延迟所述ECG采样模块的采样触发时间tp1，且满足T0<|tp1-tp2|<△t21，tp2为所述PPG采样模块的采样触发时间，T0为所述预设时间阈值；若△t21>T0，且t2<t1，则延迟所述PPG采样模块的采样触发时间tp2，且满足T0<|tp1-tp2|<△t21。
第三方面提供一种血压信号采样系统，包括；ECG采样模块、PPG采样模块、处理器；
所述处理器用于控制ECG采样模块和PPG模块同时对标准周期信号进行采样；分别获得所述ECG采样模块和所述PPG采样模块对所述标准周期信号的采样频率和采样结束时间；若所述ECG采样模块对所述标准周期信号的采样频率偏差超过预设频率阈值，则对所述ECG采样模块的采样频率进行补偿，以使所述ECG采样模块对所述标准周期信号的采样频率偏差低于预设频率阈值；若所述PPG采样模块对所述标准周期信号的采样频率偏差超过预 设频率阈值，则对所述PPG采样模块的采样频率进行补偿，以使所述PPG采样模块对所述标准周期信号的采样频率偏差低于预设频率阈值；若所述ECG采样模块和所述PPG采样模块对所述标准周期信的采样结束时间之差超过预设时间阈值，则对所述ECG采样模块或所述PPG采样模块的采样开始时间进行补偿，以使所述ECG采样模块和所述PPG采样模块对所述标准周期信号的采样结束时间之差低于预设时间阈值。
在第三方面一种可能的实现方式中，所述血压信号采样系统还包括：时钟模块，用于生成高精度时钟信号，所述高精度时钟信号的精度比所述ECG采样模块和所述PPG采样模块中的时钟信号的精度高一个数量级；
所述处理器，具体用于根据所述高精度时钟信号控制所述ECG采样模块和所述PPG采样模块同时对所述标准周期信号进行采样；根据所述高精度时钟信号记录所述ECG采样模块和所述PPG采样模块对所述标准周期信号的采样结束时间。
在第三方面一种可能的实现方式中，所述时钟模块，包括：高精度系统晶振、蓝牙模块中的时钟模块、WiFi模块中的时钟模块中的任一种；
所述高精度时钟信号由高精度系统晶振、蓝牙模块的同步校准时钟信号、WiFi模块的同步校准时钟信号中的任一种生成；
所述高精度时钟信号包括：
正弦波信号、三角波信号、锯齿波信号中的任一种。
在第三方面一种可能的实现方式中，所述处理器，还用于根据所述高精度时钟信号生成所述标准周期信号。
在第三方面一种可能的实现方式中，所述处理器，具体用于控制所述ECG采样模块对所述标准周期信号进行采样，计算采样后的数据的频率f1；控制所述PPG采样模块对所述标准周期信号进行采样，计算采样后的数据的频率f2；计算△f10＝|f1-f0|，△f20＝|f2-f0|，其中f0为所述标准周期信号的频率，△f10为所述ECG采样模块对所述标准周期信号的采样频率偏差，△f20为所述PPG采样模块对所述标准周期信号的采样频率偏差；若△f10>F0，且f1>f0，则减少所述ECG采样模块进行采样的数据个数L，(△f10-F0)≤L≤△f10，将(F1-L)作为所述ECG采样模块的新的采样频率，其中F1为所述ECG采样模块的原始采样频率，F0为预设频率阈值；若△f10>F0，且f1<f0，则增加所述ECG采样 模块进行采样的数据个数M，(△f10-F0)≤M≤△f10，将(F1+M)作为所述ECG采样模块的新的采样频率；若△f20>F0，且f2>f0，则减少所述PPG采样模块进行采样的数据个数N，(△f20-F0)≤N≤△f20，将(F2-N)作为所述PPG采样模块的新的采样频率，其中F2为所述PPG采样模块的原始采样频率；若△f20>F0，且f2<f0，则增加所述PPG采样模块进行采样的数据个数P，(△f20-F0)≤P≤△f20，将(F2+P)作为所述PPG采样模块的新的采样频率。
在第三方面一种可能的实现方式中，所述处理器，具体用于计算所述ECG采样模块和所述PPG采样模块对所述标准周期信的采样结束时间之差△t21，△t21＝|t2-t1|，t1为所述ECG采样模块对所述标准周期信的采样结束时间，t2为所述PPG采样模块对所述标准周期信的采样结束时间；若△t21>T0，且t2>t1，则延迟所述ECG采样模块的采样触发时间tp1，且满足T0<|tp1-tp2|<△t21，tp2为所述PPG采样模块的采样触发时间，T0为所述预设时间阈值；若△t21>T0，且t2<t1，则延迟所述PPG采样模块的采样触发时间tp2，且满足T0<|tp1-tp2|<△t21。
本发明实施例提供的血压检测信号采样补偿方法和装置以及血压信号采集系统，通过控制ECG采样模块和PPG采样模块对待测用户的ECG信号和PPG信号进行采样，以及对标准周期信号进行采样，以获取ECG信号和PPG信号的采样结束时间之差，以及ECG采样模块和PPG采样模块对标准周期信号的采样频率偏差，从而对ECG采样模块或PPG采样模块的采样开始时间进行补偿，以及对ECG采样模块和PPG采样模块的采样频率进行补偿，从而使ECG信号和PPG信号的采样结束时间之差低于预设时间阈值，ECG采样模块和PPG采样模块对标准周期信号的采样频率偏差低于预设频率阈值，如此根据ECG采样模块和PPG采样模块确定的PTT的误差也在允许范围内，使得通过PTT方法测量出的血压值的误差在允许范围内，提高了通过PTT方法对血压测量的精度。
附图说明
为了更清楚地说明本发明实施例或现有技术中的技术方案，下面将对实施例或现有技术描述中所需要使用的附图作一简单地介绍，显而易见地，下面描述中的附图是本发明的一些实施例，对于本领域普通技术人员来讲，在不付出创造性劳动性的前提下，还可以根据这些附图获得其他的附图。
图1为本发明实施例提供的血压检测信号采样补偿方法实施例一的流程图；
图2为本发明实施例提供的血压检测信号采样补偿方法实施例二的流程图；
图3为本发明实施例提供的血压检测信号采样补偿方法实施例三的流程图；
图4为本发明实施例提供的血压检测信号采样补偿装置实施例一的结构示意图；
图5为本发明实施例提供的血压检测信号采样补偿装置实施例二的结构示意图；
图6为本发明实施例提供的血压信号采样系统实施例一的结构示意图；
图7为本发明实施例提供的血压信号采样系统实施例二的结构示意图。
具体实施方式
为使本发明实施例的目的、技术方案和优点更加清楚，下面将结合本发明实施例中的附图，对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
采用PTT方法测量血压时，需要同步测量用户的ECG信号和PPG信号，通过对ECG信号和PPG信号进行分析，得到PTT，再通过PTT与血压之间的关系，得到收缩压和舒张压的血压值。其中，ECG信号和PPG信号分别通过相应的ECG采样模块和PPG采样模块进行采样。但由于ECG采样模块和PPG采样模块的采样频率和采样时间可能存在偏差，因此可能导致通过对ECG信号和PPG信号进行分析得到PTT存在偏差，进而可能影响最终得到的血压值。
因此，本发明实施例提供一种血压检测信号采样补偿方法，通过对ECG采样模块和PPG采样模块采集到的信号进行补偿，使得最终测量到的血压值的偏差小于预设的阈值。
图1为本发明实施例提供的血压检测信号采样补偿方法实施例一的流程 图，如图1所示，本实施例提供的方法包括；
步骤S101，控制ECG采样模块和PPG采样模块同时对标准周期信号进行采样。
具体地，由于ECG信号和PPG信号是分别由ECG采样模块和PPG采样模块进行采集的，ECG采样模块和PPG采样模块是相互独立的，因此ECG采样模块和PPG采样模块的采样时间和采样频率可能存在偏差，所以才会导致采样得到的ECG信号和PPG信号的时间同步或频率同步存在偏差，进而导致PTT存在误差。因此，解决PTT误差，就是要消除ECG采样模块和PPG采样模块的采样时间偏差和采样频率偏差。那么首先就要测量出ECG采样模块和PPG采样模块的采样时间偏差和采样频率偏差，从而才能对ECG采样模块和PPG采样模块的采样时间和采样频率进行补偿，使PTT误差减小到允许范围内，进而使通过PTT方法测量出的血压值的误差在允许范围内。
为了测量出ECG采样模块和PPG采样模块的采样时间偏差和采样频率偏差，可以分别控制ECG采样模块和PPG采样模块同时对一个标准周期信号进行采样，
步骤S102，分别获得ECG采样模块和PPG采样模块对标准周期信号的采样频率和采样结束时间。
那么首先，在分别控制ECG采样模块和PPG采样模块同时对标准周期信号进行采样时，分别记录ECG采样模块和PPG采样模块采样得到的信号的采样频率，以及分别记录采样结束时间。
控制ECG采样模块和PPG采样模块同时进行采样，可以使用一个定时器来实现，控制器根据定时器的触发，同时向ECG采样模块和PPG采样模块发送采样通知消息，以使ECG采样模块和PPG采样模块实现同时测量。由于PTT需要由ECG采样模块和PPG采样模块采集到的信号进行同步比较获得，因此ECG采样模块和PPG采样模块进行采样的数据量或者说采样时间应该是相同的。但是由于ECG采样模块和PPG采样模块可能存在采样误差，因此，虽然ECG采样模块和PPG采样模块是同时开始采样的，可采样结束时间可能不同，因此分别对ECG采样模块和PPG采样模块的采样结束的时间进行记录。
为了检测出ECG采样模块和PPG采样模块的采样频率误差，需要找到 一个已知的参考信号，分别测量出ECG采样模块和PPG采样模块对该已知的参考信号进行的采样后频率，即可获知ECG采样模块和PPG采样模块的采样频率误差。在此，分别控制ECG采样模块和PPG采样模块对标准周期信号进行采样，该标准周期信号是一个标准的正弦波、方波、三角波、锯齿波等信号，且频率是已知且稳定的。标准周期信号可以采用现有的一个周期信号，或者还可以是新生成的一个周期信号。
步骤S103，若ECG采样模块对标准周期信号的采样频率偏差超过预设频率阈值，则对ECG采样模块的采样频率进行补偿，以使ECG采样模块对标准周期信号的采样频率偏差低于预设频率阈值。
具体地，在ECG采样模块和PPG采样模块分别对标准周期信号进行采样后，可以分别得到采样后的数据，分别对两个采样后的数据进行分析后，可以获知采样后的数据的频率。将得到的两个采样后的数据的频率与标准周期信号的频率进行比较，即可分别计算出ECG采样模块和PPG采样模块对标准周期信号的采样频率偏差。
由于标准周期信号的频率是稳定的，因此，对标准周期信号进行采样的误差体现了ECG采样模块和PPG采样模块的系统采样误差。对ECG采样模块和PPG采样模块的系统采样误差进行补偿，即可消除ECG采样模块和PPG采样模块的采样误差。
在计算出ECG采样模块对标准周期信号的采样频率偏差后，若ECG采样模块对标准周期信号的采样频率偏差未超过预设频率阈值，则意味着ECG采样模块的采样频率偏差在允许范围内，无需进行补偿。
若ECG采样模块对标准周期信号的采样频率偏差超过预设频率阈值，那么ECG采样模块的采样频率偏差超过允许范围需要对其进行补偿。对ECG采样模块进行补偿的目的是要使ECG采样模块对标准周期信号的采样频率偏差低于预设频率阈值。而对ECG采样模块进行补偿手段是增加或减小ECG采样模块进行采样的取样点数，从而增加或减小ECG采样模块的采样频率。
步骤S104，若PPG采样模块对标准周期信号的采样频率偏差超过预设频率阈值，则对所述PPG采样模块的采样频率进行补偿，以使PPG采样模块对标准周期信号的采样频率偏差低于预设频率阈值。
具体地，在计算出PPG采样模块对标准周期信号的采样频率偏差后，若 PPG采样模块对标准周期信号的采样频率偏差未超过预设频率阈值，则意味着PPG采样模块的采样频率偏差在允许范围内，无需进行补偿。
若PPG采样模块对标准周期信号的采样频率偏差超过预设频率阈值，那么PPG采样模块的采样频率偏差超过允许范围需要对其进行补偿。对PPG采样模块进行补偿的目的是要使PPG采样模块对标准周期信号的采样频率偏差低于预设频率阈值。而对PPG采样模块进行补偿手段是增加或减小PPG采样模块进行采样的取样点数，从而增加或减小PPG采样模块的采样频率。
将补偿后的ECG采样模块的采样频率和PPG信号的采样频率作为ECG采样模块和PPG采样模块的新的采样频率。这样即可消除由于ECG采样模块和PPG采样模块的采样频率偏差对计算PTT所带来的影响。
步骤S105，若ECG采样模块和PPG采样模块对标准周期信的采样结束时间之差超过预设时间阈值，则对ECG采样模块或PPG采样模块的采样开始时间进行补偿，以使ECG采样模块和PPG采样模块对标准周期信号的采样结束时间之差低于预设时间阈值。
在获取ECG采样模块和PPG采样模块对标准周期信的采样结束时间后，对其进行判断，判断两者之差是否超过预设时间阈值。该预设时间阈值为允许偏差的误差范围，可根据对血压测量的不同精度需求确定，例如在家用级别的血压测量中，该预设时间阈值可以设置的相对较大，而在医用级别的血压测量中，该预设时间阈值需要设置的相对较小。如果ECG采样模块和PPG采样模块对标准周期信的采样结束时间之差未超过预设时间阈值，则意味着ECG采样模块和PPG采样模块的采样时间偏差在允许范围内，无需进行补偿。
而如果ECG采样模块和PPG采样模块对标准周期信的采样结束时间之差超过预设时间阈值，那么ECG采样模块和PPG采样模块的采样时间偏差超过允许范围，需要对其进行补偿。该补偿可以是对ECG采样模块进行补偿，也可以是对PPG采样模块进行补偿，可以是延迟ECG采样模块或PPG采样模块的开始采样时间，也可以是提前ECG采样模块或PPG采样模块的开始采样时间。但一般地，是延迟ECG采样模块或PPG采样模块的开始采样时间。总之，要使ECG采样模块和PPG采样模块对标准周期信的采样结束时间之差低于预设时间阈值，将补偿后的ECG采样模块的开始采样时间和PPG信号的采样开始时间作为ECG采样模块和PPG采样模块的新的开始采样时 间。这样即可消除由于ECG采样模块和PPG采样模块的时间偏差对计算PTT所带来的影响。
本实施例提供的血压检测信号采样补偿方法，通过控制ECG采样模块和PPG采样模块对标准周期信号进行采样，以分别获得ECG采样模块和PPG采样模块对标准周期信号的采样频率和采样结束时间，从而对ECG采样模块或PPG采样模块的采样开始时间进行补偿，以及对ECG采样模块和PPG采样模块的采样频率进行补偿，从而使ECG采样模块和PPG采样模块对标准周期信号的采样结束时间之差低于预设时间阈值，ECG采样模块和PPG采样模块对标准周期信号的采样频率偏差低于预设频率阈值，如此根据ECG采样模块和PPG采样模块确定的PTT的误差也在允许范围内，使得通过PTT方法测量出的血压值的误差在允许范围内，提高了通过PTT方法对血压测量的精度。
为了保证ECG采样模块和PPG采样模块的开始时间精确同步，以及所采样的标准周期信号频率稳定，因此，需要有一个高精度的时钟信号作为时间同步的基础，以及作为生成标准周期信号的基础。那么在对标准周期信号进行采样之前，还可以生成高精度时钟信号，高精度时钟信号的精度比ECG采样模块和PPG采样模块中的时钟信号的精度高一个数量级。高精度的时钟信号能够保证对ECG采样模块和PPG采样模块的开始采样时间和采样结束时间的精确记录，以及保证根据高精度时钟信号生成的标准周期信号频率稳定。
高精度时钟信号由高精度系统晶振、蓝牙模块的同步校准时钟信号、无线保真(Wireless Fidelity，WiFi)模块的同步校准时钟信号中的任一种生成。高精度时钟信号包括：正弦波信号、三角波信号、锯齿波信号中的任一种。
图2为本发明实施例提供的血压检测信号采样补偿方法实施例二的流程图，如图2所述，本实施例提供的方法包括：
步骤S201，控制ECG采样模块对标准周期信号进行采样，计算采样后的数据的频率f1。
步骤S202，控制PPG采样模块对标准周期信号进行采样，计算采样后的数据的频率f2。
具体地，本实施例提供的血压检测信号采样补偿方法是对血压检测信号 的频率误差进行补偿的具体方法。首先，控制ECG采样模块对标准周期信号进行采样，获取多个采样数据。然后根据获取到的多个采样数据确定采样得到的信号的频率，记为f1。控制PPG采样模块对标准周期信号进行采样，获取多个采样数据。然后根据获取到的多个采样数据确定采样得到的信号的频率，记为f2。标准周期信号是具有一个固定频率的正弦波信号、三角波信号、方波信号、锯齿波信号等任一种信号。对标准周期信号的频率进行采样的方法可以是采用最大值法或最小值法，提取获取到的K个数据的波峰值来计算出各数据的频率
Figure PCTCN2016102823-appb-000001
然后对K个周期的K个数据的频率取平均值得到f1，
Figure PCTCN2016102823-appb-000002
同理，可以根据上述方法得到f2，
Figure PCTCN2016102823-appb-000003
步骤S203，计算△f10＝|f1-f0|，△f20＝|f2-f0|，其中f0为标准周期信号的频率，△f10为ECG采样模块对标准周期信号的采样频率偏差，△f20为PPG采样模块对标准周期信号的采样频率偏差。
具体地，在得到f1和f2后，即可根据公式△f10＝|f1-f0|，△f20＝|f2-f0|计算ECG采样模块和PPG采样模块对标准周期信号的采样频率偏差。其中f0为标准周期信号的频率。△f10为ECG采样模块对标准周期信号的采样频率偏差，△f20为PPG采样模块对标准周期信号的采样频率偏差。
步骤S204，判断ECG采样模块对标准周期信号的采样频率偏差是否超过预设频率阈值。
具体地，根据△f10和F0之间的关系，判断ECG采样模块对标准周期信号的采样频率偏差是否超过预设频率阈值，其中F0为预设频率阈值。若△f10≤F0，则表示ECG采样模块对标准周期信号的采样频率偏差是未超过预设频率阈值，那么无需对ECG采样模块的采样频率进行补偿，可结束此流程。若△f10>F0，则还需判断f1和f0之前的关系，若f1>f0，则执行步骤S205，若f1<f0，则执行步骤S206。
步骤S205，若△f10>F0，且f1>f0，则减少ECG采样模块进行采样的数据个数L，(△f10-F0)≤L≤△f10，将(F1-L)作为ECG采样模块的新的采样频率，其中F1为ECG采样模块的原始采样频率，F0为预设频率阈值。
具体地，若△f10>F0，则表示ECG采样模块对标准周期信号的采样频率偏差超过预设频率阈值，而f1>f0表示ECG采样模块对标准周期信号进行采 样的频率高于标准周期信号的频率，那么需要降低ECG采样模块的采样频率。降低ECG采样模块的采样频率的方法可以是减少ECG采样模块进行采样的数据个数L，其中，(△f10-F0)≤L≤△f10，从而可以保证ECG采样模块的新的采样频率(F1-L)的采样频率偏差能够满足需求。其中F1为ECG采样模块的原始采样频率。
减少ECG采样模块进行采样的数据个数L的方法可以是，每隔指定长度l，l＝(f1/L)，抽取一个数据。
步骤S206，若△f10>F0，且f1<f0，则增加ECG采样模块进行采样的数据个数M，(△f10-F0)≤M≤△f10，将(F1+M)作为ECG采样模块的新的采样频率。
具体地，若△f10>F0，则表示ECG采样模块对标准周期信号的采样频率偏差超过预设频率阈值，而f1<f0表示ECG采样模块对标准周期信号进行采样的频率低于标准周期信号的频率，那么需要提高ECG采样模块的采样频率。提高ECG采样模块的采样频率的方法可以是增加对ECG采样模块进行采样的数据个数M，其中，(△f10-F0)≤M≤△f10，从而可以保证ECG采样模块的新的采样频率(F1+M)的采样频率偏差能够满足需求。
增加ECG采样模块进行采样的数据个数M的方法可以是，每隔指定长度m，m＝(f1/M)，增加一个数据。
步骤S207，判断PPG采样模块对标准周期信号的采样频率偏差是否超过预设频率阈值。
具体地，根据△f20和F0之间的关系，判断PPG采样模块对标准周期信号的采样频率偏差是否超过预设频率阈值。若△f20≤F0，则表示PPG采样模块对标准周期信号的采样频率偏差是未超过预设频率阈值，那么无需对PPG采样模块的采样频率进行补偿，可结束此流程。若△f20>F0，则还需判断f2和f0之前的关系，若f2>f0，则执行步骤S208，若f2<f0，则执行步骤S209。
步骤S208，若△f20>F0，且f2>f0，则减少PPG采样模块进行采样的数据个数N，(△f20-F0)≤N≤△f20，将(F2-N)作为PPG采样模块的新的采样频率，其中F2为所述PPG采样模块的原始采样频率。
具体地，若△f20>F0，则表示PPG采样模块对标准周期信号的采样频率偏差超过预设频率阈值，而f2>f0表示PPG采样模块对标准周期信号进行采样的频率高于标准周期信号的频率，那么需要降低PPG采样模块的采样频率。 降低PPG采样模块的采样频率的方法可以是减少PPG采样模块进行采样的数据个数N，其中，(△f20-F0)≤N≤△f20，从而可以保证PPG采样模块的新的采样频率(F2-N)的采样频率偏差能够满足需求。其中F2为PPG采样模块的原始采样频率。
减少PPG采样模块进行采样的数据个数N的方法可以是，每隔指定长度n，n＝(f1/N)，抽取一个数据。
步骤S209，若△f20>F0，且f2<f0，则增加PPG采样模块进行采样的数据个数P，(△f20-F0)≤P≤△f20，将(F2+P)作为所述PPG采样模块的新的采样频率。
具体地，若△f20>F0，则表示PPG采样模块对标准周期信号的采样频率偏差超过预设频率阈值，而f2<f0表示PPG采样模块对标准周期信号进行采样的频率低于标准周期信号的频率，那么需要提高PPG采样模块的采样频率。提高PPG采样模块的采样频率的方法可以是增加PPG采样模块进行采样的数据个数P，其中，(△f20-F0)≤P≤△f20，从而可以保证PPG采样模块的新的采样频率(F2+P)的采样频率偏差能够满足需求。
增加PPG采样模块进行采样的数据个数P的方法可以是，每隔指定长度p，p＝(f1/P)，增加一个数据。
图3为本发明实施例提供的血压检测信号采样补偿方法实施例三的流程图，如图3所述，本实施例提供的方法包括：
步骤S301，控制ECG采样模块和PPG采样模块同时对标准周期信号进行采样，并分别记录采样结束时间。
具体地，可以设置一个定时器，该定时器可以触发对一个采样触发信号，在定时器到时，同时控制ECG采样模块和PPG采样模块对标准周期信号进行采样。并分别记录ECG采样模块的采样结束时间t1和PPG采样模块的采样结束时间t2。
步骤S302，计算ECG采样模块和PPG采样模块对标准周期信号的采样结束时间之差△t21，△t21＝|t2-t1|。
具体地，为了对ECG采样模块和PPG采样模块的采样时间进行补偿，需要先确定ECG采样模块和PPG采样模块对标准周期信号的采样结束时间之差△t21，△t21＝|t2-t1|。
步骤S303，判断ECG采样模块和PPG采样模块对标准周期信号的采样 结束时间之差是否超过预设时间阈值。
具体地，根据△t21和T0之间的关系，判断ECG采样模块和PPG采样模块对标准周期信号的采样结束时间之差是否超过预设时间阈值，其中T0为预设时间阈值。若△t21≤T0，则表示ECG采样模块和PPG采样模块对标准周期信号的采样结束时间之差未超过预设时间阈值，那么无需对ECG采样模块和PPG采样模块的采样时间进行补偿，可结束此流程。若△t21>T0，则还需判断t2和t1之前的关系，若t2>t1，则执行步骤S304，若t2<t1，则执行步骤S305。
步骤S304，若△t21>T0，且t2>t1，则延迟所述ECG采样模块的采样触发时间tp1，且满足T0<|tp1-tp2|<△t21，tp2为所述PPG采样模块的采样触发时间，T0为所述预设时间阈值。
具体地，若△t21>T0，则表示ECG采样模块和PPG采样模块对标准周期信号的采样结束时间之差超过预设时间阈值，而t2>t1表示PPG采样模块的采样结束时间晚于ECG采样模块的采用结束时间，那么需要将ECG采样模块的采样开始时间tp1延迟，并满足T0<|tp1-tp2|<△t21，tp2为所述PPG采样模块的采样触发时间。当然，将PPG采样模块的采样触发时间提前同样可以实现对采样时间的补偿。
步骤S305，若△t21>T0，且t2<t1，则延迟所述PPG采样模块的采样触发时间tp2，且满足T0<|tp1-tp2|<△t21。
具体地，若△t21>T0，则表示ECG采样模块和PPG采样模块对标准周期信号的采样结束时间之差超过预设时间阈值，而t2<t1表示PPG采样模块的采样结束时间早于ECG采样模块的采用结束时间，那么需要将PPG采样模块的采样开始时间tp2延迟，并满足T0<|tp1-tp2|<△t21。当然，将ECG采样模块的采样触发时间提前同样可以实现对采样时间的补偿。
图4为本发明实施例提供的血压检测信号采样补偿装置实施例一的结构示意图，如图4所示，本实施提供的血压检测信号采样补偿装置包括；
控制模块41，用于控制ECG采样模块和PPG模块同时对标准周期信号进行采样。
计算模块42，用于分别获得所述ECG采样模块和所述PPG采样模块对所述标准周期信号的采样频率和采样结束时间。
补偿模块43，用于若所述ECG采样模块对所述标准周期信号的采样频 率偏差超过预设频率阈值，则对所述ECG采样模块的采样频率进行补偿，以使所述ECG采样模块对所述标准周期信号的采样频率偏差低于预设频率阈值；若所述PPG采样模块对所述标准周期信号的采样频率偏差超过预设频率阈值，则对所述PPG采样模块的采样频率进行补偿，以使所述PPG采样模块对所述标准周期信号的采样频率偏差低于预设频率阈值；若所述ECG采样模块和所述PPG采样模块对所述标准周期信的采样结束时间之差超过预设时间阈值，则对所述ECG采样模块或所述PPG采样模块的采样开始时间进行补偿，以使所述ECG采样模块和所述PPG采样模块对所述标准周期信号的采样结束时间之差低于预设时间阈值。
本实施例提供的血压检测信号采样补偿装置用于实现图1所示的血压检测信号采样补偿方法的方法步骤，其实现原理和技术效果类似，此处不再赘述。
图5为本发明实施例提供的血压检测信号采样补偿装置实施例二的结构示意图，如图5所示，本实施例提供的血压检测信号采样补偿装置在图4的基础上，还包括：
时钟模块51，用于生成高精度时钟信号，所述高精度时钟信号的精度比所述ECG采样模块和所述PPG采样模块中的时钟信号的精度高一个数量级。
控制模块41，具体用于根据所述高精度时钟信号控制所述ECG采样模块和所述PPG采样模块同时对所述标准周期信号进行采样；根据所述高精度时钟信号记录所述ECG采样模块和所述PPG采样模块对所述标准周期信号的采样结束时间。
进一步地，在图5所示实施例中，所述高精度时钟信号由高精度系统晶振、蓝牙模块的同步校准时钟信号、WiFi模块的同步校准时钟信号中的任一种生成；所述高精度时钟信号包括：正弦波信号、三角波信号、锯齿波信号中的任一种。
进一步地，在图4或图5所示实施例中，计算模块42，还用于根据所述高精度时钟信号生成所述标准周期信号。
进一步地，在图4或图5所示实施例中，控制模块41，具体用于控制所述ECG采样模块对所述标准周期信号进行采样，计算采样后的数据的频率f1；控制所述PPG采样模块对所述标准周期信号进行采样，计算采样后的数据的 频率f2。计算模块42，具体用于计算△f10＝|f1-f0|，△f20＝|f2-f0|，其中f0为所述标准周期信号的频率，△f10为所述ECG采样模块对所述标准周期信号的采样频率偏差，△f20为所述PPG采样模块对所述标准周期信号的采样频率偏差。补偿模块43，具体用于若△f10>F0，且f1>f0，则减少所述ECG采样模块进行采样的数据个数L，(△f10-F0)≤L≤△f10，将(F1-L)作为所述ECG采样模块的新的采样频率，其中F1为所述ECG采样模块的原始采样频率，F0为预设频率阈值；若△f10>F0，且f1<f0，则增加所述ECG采样模块进行采样的数据个数M，(△f10-F0)≤M≤△f10，将(F1+M)作为所述ECG采样模块的新的采样频率；若△f20>F0，且f2>f0，则减少所述PPG采样模块进行采样的数据个数N，(△f20-F0)≤N≤△f20，将(F2-N)作为所述PPG采样模块的新的采样频率，其中F2为所述PPG采样模块的原始采样频率；若△f20>F0，且f2<f0，则增加所述PPG采样模块进行采样的数据个数P，(△f20-F0)≤P≤△f20，将(F2+P)作为所述PPG采样模块的新的采样频率。
进一步地，在图4或图5所示实施例中，计算模块42，还用于计算所述采样模块和所述PPG采样模块对所述标准周期信的采样结束时间之差△t21，△t21＝|t2-t1|，t1为所述ECG采样模块对所述标准周期信的采样结束时间，t2为所述PPG采样模块对所述标准周期信的采样结束时间。补偿模块43，具体用于若△t21>T0，且t2>t1，则延迟所述ECG采样模块的采样触发时间tp1，且满足T0<|tp1-tp2|<△t21，tp2为所述PPG采样模块的采样触发时间，T0为所述预设时间阈值；若△t21>T0，且t2<t1，则延迟所述PPG采样模块的采样触发时间tp2，且满足T0<|tp1-tp2|<△t21。
图6为本发明实施例提供的血压信号采样系统实施例一的结构示意图，如图6所示，本实施例提供的血压信号采样系统包括；ECG采样模块61、PPG采样模块62和处理器63。
处理器63用于控制ECG采样模块61和PPG模块62同时对标准周期信号进行采样；分别获得ECG采样模块61和PPG采样模块62对所述标准周期信号的采样频率和采样结束时间；若ECG采样模块61对所述标准周期信号的采样频率偏差超过预设频率阈值，则对ECG采样模块61的采样频率进行补偿，以使ECG采样模块61对所述标准周期信号的采样频率偏差低于预设频率阈值；若PPG采样模块62对所述标准周期信号的采样频率偏差超过 预设频率阈值，则对PPG采样模块62的采样频率进行补偿，以使PPG采样模块62对所述标准周期信号的采样频率偏差低于预设频率阈值；若ECG采样模块61和PPG采样模块62对所述标准周期信的采样结束时间之差超过预设时间阈值，则对ECG采样模块61或PPG采样模块62的采样开始时间进行补偿，以使ECG采样模块61和PPG采样模块62对所述标准周期信号的采样结束时间之差低于预设时间阈值。
具体地，本实施例提供的血压信号采样系统可以是任一种能够根据PTT方法进行血压检测的系统。例如可以是家用的腕式血压检测仪、臂式血压检测仪，或者可以是医用的任一种血压检测仪。其包括ECG采样模块61和PPG采样模块62。其中，ECG采样模块61用于采集用户的心电信号，其由心电传感器和心电信号采样芯片组成，可以采用集成式模拟前端芯片(例如ADS1292)或分立式采样芯片。PPG采样模块62由PPG光学传感器和PPG采样芯片组成，可以采用集成式模拟前端芯片(例如AFE4404/ADPD153)或分立式采样芯片。
处理器63可以是任一种具有处理功能的硬件芯片。
图7为本发明实施例提供的血压信号采样系统实施例二的结构示意图，如图7所示，本实施例提供的血压信号采样系统在图6的基础上，还包括；
时钟模块71，用于生成高精度时钟信号，所述高精度时钟信号的精度比ECG采样模块61和PPG采样模块62中的时钟信号的精度高一个数量级。
处理器63，具体用于根据高精度时钟信号控制ECG采样模块61和PPG采样模块62同时对所述标准周期信号进行采样；根据所述高精度时钟信号记录ECG采样模块61和PPG采样模块62对所述标准周期信号的采样结束时间。
时钟模块71可以为高精度系统晶振、蓝牙模块中的时钟模块、无线保真WiFi模块中的时钟模块中的任一种。所述高精度时钟信号包括：正弦波信号、三角波信号、锯齿波信号中的任一种。
进一步地，在图6或图7所示实施例中，处理器63，还用于根据所述高精度时钟信号生成所述标准周期信号。
进一步地，在图6或图7所示实施例中，处理器63，具体用于控制ECG采样模块61对所述标准周期信号进行采样，计算采样后的数据的频率f1；控 制PPG采样模块62对所述标准周期信号进行采样，计算采样后的数据的频率f2；计算△f10＝|f1-f0|，△f20＝|f2-f0|，其中f0为所述标准周期信号的频率，△f10为ECG采样模块61对所述标准周期信号的采样频率偏差，△f20为PPG采样模块62对所述标准周期信号的采样频率偏差；若△f10>F0，且f1>f0，则减少ECG采样模块61进行采样的数据个数L，(△f10-F0)≤L≤△f10，将(F1-L)作为ECG采样模块61的新的采样频率，其中F1为ECG采样模块61的原始采样频率，F0为预设频率阈值；若△f10>F0，且f1<f0，则增加ECG采样模块61进行采样的数据个数M，(△f10-F0)≤M≤△f10，将(F1+M)作为ECG采样模块61的新的采样频率；若△f20>F0，且f2>f0，则减少PPG采样模块61进行采样的数据个数N，(△f20-F0)≤N≤△f20，将(F2-N)作为PPG采样模块62的新的采样频率，其中F2为PPG采样模块62的原始采样频率；若△f20>F0，且f2<f0，则增加PPG采样模块62进行采样的数据个数P，(△f20-F0)≤P≤△f20，将(F2+P)作为PPG采样模块62的新的采样频率。
进一步地，在图6或图7所示实施例中，处理器63，具体用于计算ECG采样模块61和PPG采样模块62对所述标准周期信的采样结束时间之差△t21，△t21＝|t2-t1|，t1为所述ECG采样模块61对所述标准周期信的采样结束时间，t2为所述PPG采样模块62对所述标准周期信的采样结束时间；若△t21>T0，且t2>t1，则延迟ECG采样模块61的采样触发时间tp1，且满足T0<|tp1-tp2|<△t21，tp2为PPG采样模块62的采样触发时间，T0为所述预设时间阈值；若△t21>T0，且t2<t1，则延迟PPG采样模块62的采样触发时间tp2，且满足T0<|tp1-tp2|<△t21。
本领域普通技术人员可以理解：实现上述各方法实施例的全部或部分步骤可以通过程序指令相关的硬件来完成。前述的程序可以存储于一计算机可读取存储介质中。该程序在执行时，执行包括上述各方法实施例的步骤；而前述的存储介质包括：ROM、RAM、磁碟或者光盘等各种可以存储程序代码的介质。
最后应说明的是：以上各实施例仅用以说明本发明的技术方案，而非对其限制；尽管参照前述各实施例对本发明进行了详细的说明，本领域的普通技术人员应当理解：其依然可以对前述各实施例所记载的技术方案进行修改，或者对其中部分或者全部技术特征进行等同替换。因此，本发明的保护范围应以权利要求书的保护范围为准。

Claims (18)

  1. 一种血压检测信号采样补偿方法，其特征在于，包括；
    控制心电图ECG采样模块和光电容积描记图PPG模块同时对标准周期信号进行采样；
    分别获得所述ECG采样模块和所述PPG采样模块对所述标准周期信号的采样频率和采样结束时间；
    若所述ECG采样模块对所述标准周期信号的采样频率偏差超过预设频率阈值，则对所述ECG采样模块的采样频率进行补偿，以使所述ECG采样模块对所述标准周期信号的采样频率偏差低于预设频率阈值；
    若所述PPG采样模块对所述标准周期信号的采样频率偏差超过预设频率阈值，则对所述PPG采样模块的采样频率进行补偿，以使所述PPG采样模块对所述标准周期信号的采样频率偏差低于预设频率阈值；
    若所述ECG采样模块和所述PPG采样模块对所述标准周期信的采样结束时间之差超过预设时间阈值，则对所述ECG采样模块或所述PPG采样模块的采样开始时间进行补偿，以使所述ECG采样模块和所述PPG采样模块对所述标准周期信号的采样结束时间之差低于预设时间阈值。
  2. 根据权利要求1所述的方法，其特征在于，所述控制ECG采样模块和PPG采样模块同时对标准周期信号进行采样之前，还包括：
    生成高精度时钟信号，所述高精度时钟信号的精度比所述ECG采样模块和所述PPG采样模块中的时钟信号的精度高一个数量级；
    所述控制ECG采样模块和PPG采样模块同时对标准周期信号进行采样，包括：
    根据所述高精度时钟信号控制所述ECG采样模块和所述PPG采样模块同时对所述标准周期信号进行采样；
    所述分别获得所述ECG采样模块和所述PPG采样模块对所述标准周期信号的采样频率和采样结束时间，包括：
    根据所述高精度时钟信号记录所述ECG采样模块和所述PPG采样模块对所述标准周期信号的采样结束时间。
  3. 根据权利要求2所述的方法，其特征在于，所述高精度时钟信号由高精度系统晶振、蓝牙模块的同步校准时钟信号、无线保真WiFi模块的同步校 准时钟信号中的任一种生成；
    所述高精度时钟信号包括：
    正弦波信号、三角波信号、锯齿波信号中的任一种。
  4. 根据权利要求2或3所述的方法，其特征在于，所述控制ECG采样模块和PPG采样模块分别对标准周期信号进行采样之前，还包括：
    根据所述高精度时钟信号生成所述标准周期信号。
  5. 根据权利要求1～4任一项所述的方法，其特征在于，所述控制ECG采样模块和PPG采样模块分别对标准周期信号进行采样，包括：
    控制所述ECG采样模块对所述标准周期信号进行采样，计算采样后的数据的频率f1；
    控制所述PPG采样模块对所述标准周期信号进行采样，计算采样后的数据的频率f2；
    所述分别获得所述ECG采样模块和所述PPG采样模块对所述标准周期信号的采样频率和采样结束时间，包括：
    计算△f10＝|f1-f0|，△f20＝|f2-f0|，其中f0为所述标准周期信号的频率，△f10为所述ECG采样模块对所述标准周期信号的采样频率偏差，△f20为所述PPG采样模块对所述标准周期信号的采样频率偏差；
    所述若所述ECG采样模块对所述标准周期信号的采样频率偏差超过预设频率阈值，则对所述ECG采样模块的采样频率进行补偿，以使所述ECG采样模块对所述标准周期信号的采样频率偏差低于预设频率阈值，包括：
    若△f10>F0，且f1>f0，则减少所述ECG采样模块进行采样的数据个数L，(△f10-F0)≤L≤△f10，将(F1-L)作为所述ECG采样模块的新的采样频率，其中F1为所述ECG采样模块的原始采样频率，F0为预设频率阈值；
    若△f10>F0，且f1<f0，则增加所述ECG采样模块进行采样的数据个数M，(△f10-F0)≤M≤△f10，将(F1+M)作为所述ECG采样模块的新的采样频率；
    所述若所述PPG采样模块对所述标准周期信号的采样频率偏差超过预设频率阈值，则对所述PPG采样模块的采样频率进行补偿，以使所述PPG采样模块对所述标准周期信号的采样频率偏差低于预设频率阈值，包括：
    若△f20>F0，且f2>f0，则减少所述PPG采样模块进行采样的数据个数N，(△f20-F0)≤N≤△f20，将(F2-N)作为所述PPG采样模块的新的采样频率，其中F2 为所述PPG采样模块的原始采样频率；
    若△f20>F0，且f2<f0，则增加所述PPG采样模块进行采样的数据个数P，(△f20-F0)≤P≤△f20，将(F2+P)作为所述PPG采样模块的新的采样频率。
  6. 根据权利要求1～5任一项所述的方法，其特征在于，所述若所述ECG采样模块和所述PPG采样模块对所述标准周期信的采样结束时间之差超过预设时间阈值，则对所述ECG采样模块或所述PPG采样模块的采样开始时间进行补偿，以使所述ECG采样模块和所述PPG采样模块对所述标准周期信号的采样结束时间之差低于预设时间阈值，包括：
    计算所述ECG采样模块和所述PPG采样模块对所述标准周期信的采样结束时间之差△t21，△t21＝|t2-t1|，t1为所述ECG采样模块对所述标准周期信的采样结束时间，t2为所述PPG采样模块对所述标准周期信的采样结束时间；
    若△t21>T0，且t2>t1，则延迟所述ECG采样模块的采样触发时间tp1，且满足T0<|tp1-tp2|<△t21，tp2为所述PPG采样模块的采样触发时间，T0为所述预设时间阈值；
    若△t21>T0，且t2<t1，则延迟所述PPG采样模块的采样触发时间tp2，且满足T0<|tp1-tp2|<△t21。
  7. 一种血压检测信号采样补偿装置，其特征在于，包括；
    控制模块，用于控制心电图ECG采样模块和光电容积描记图PPG模块同时对标准周期信号进行采样；
    计算模块，用于分别获得所述ECG采样模块和所述PPG采样模块对所述标准周期信号的采样频率和采样结束时间；
    补偿模块，用于若所述ECG采样模块对所述标准周期信号的采样频率偏差超过预设频率阈值，则对所述ECG采样模块的采样频率进行补偿，以使所述ECG采样模块对所述标准周期信号的采样频率偏差低于预设频率阈值；若所述PPG采样模块对所述标准周期信号的采样频率偏差超过预设频率阈值，则对所述PPG采样模块的采样频率进行补偿，以使所述PPG采样模块对所述标准周期信号的采样频率偏差低于预设频率阈值；若所述ECG采样模块和所述PPG采样模块对所述标准周期信的采样结束时间之差超过预设时间阈值，则对所述ECG采样模块或所述PPG采样模块的采样开始时间进行补偿，以使所述ECG采样模块和所述PPG采样模块对所述标准周期信号的采样结束 时间之差低于预设时间阈值。
  8. 根据权利要求7所述的装置，其特征在于，还包括：时钟模块，用于生成高精度时钟信号，所述高精度时钟信号的精度比所述ECG采样模块和所述PPG采样模块中的时钟信号的精度高一个数量级；
    所述控制模块，具体用于根据所述高精度时钟信号控制所述ECG采样模块和所述PPG采样模块同时对所述标准周期信号进行采样；根据所述高精度时钟信号记录所述ECG采样模块和所述PPG采样模块对所述标准周期信号的采样结束时间。
  9. 根据权利要求8所述的装置，其特征在于，所述高精度时钟信号由高精度系统晶振、蓝牙模块的同步校准时钟信号、无线保真WiFi模块的同步校准时钟信号中的任一种生成；
    所述高精度时钟信号包括：
    正弦波信号、三角波信号、锯齿波信号中的任一种。
  10. 根据权利要求8或9所述的装置，其特征在于，所述计算模块，还用于根据所述高精度时钟信号生成所述标准周期信号。
  11. 根据权利要求7～10任一项所述的装置，其特征在于，所述控制模块，具体用于控制所述ECG采样模块对所述标准周期信号进行采样，计算采样后的数据的频率f1；控制所述PPG采样模块对所述标准周期信号进行采样，计算采样后的数据的频率f2；
    所述计算模块，具体用于计算△f10＝|f1-f0|，△f20＝|f2-f0|，其中f0为所述标准周期信号的频率，△f10为所述ECG采样模块对所述标准周期信号的采样频率偏差，△f20为所述PPG采样模块对所述标准周期信号的采样频率偏差；
    所述补偿模块，具体用于若△f10>F0，且f1>f0，则减少所述ECG采样模块进行采样的数据个数L，(△f10-F0)≤L≤△f10，将(F1-L)作为所述ECG采样模块的新的采样频率，其中F1为所述ECG采样模块的原始采样频率，F0为预设频率阈值；若△f10>F0，且f1<f0，则增加所述ECG采样模块进行采样的数据个数M，(△f10-F0)≤M≤△f10，将(F1+M)作为所述ECG采样模块的新的采样频率；若△f20>F0，且f2>f0，则减少所述PPG采样模块进行采样的数据个数N，(△f20-F0)≤N≤△f20，将(F2-N)作为所述PPG采样模块的新的采样频率，其中F2为所述PPG采样模块的原始采样频率；若△f20>F0，且f2<f0，则增加所述PPG 采样模块进行采样的数据个数P，(△f20-F0)≤P≤△f20，将(F2+P)作为所述PPG采样模块的新的采样频率。
  12. 根据权利要求7～11任一项所述的装置，其特征在于，所述计算模块，还用于计算所述采样模块和所述PPG采样模块对所述标准周期信的采样结束时间之差△t21，△t21＝|t2-t1|，t1为所述ECG采样模块对所述标准周期信的采样结束时间，t2为所述PPG采样模块对所述标准周期信的采样结束时间；
    所述补偿模块，具体用于若△t21>T0，且t2>t1，则延迟所述ECG采样模块的采样触发时间tp1，且满足T0<|tp1-tp2|<△t21，tp2为所述PPG采样模块的采样触发时间，T0为所述预设时间阈值；若△t21>T0，且t2<t1，则延迟所述PPG采样模块的采样触发时间tp2，且满足T0<|tp1-tp2|<△t21。
  13. 一种血压信号采样系统，其特征在于，包括；心电图ECG采样模块、光电容积描记图PPG采样模块、处理器；
    所述处理器用于控制所述ECG采样模块和所述PPG模块同时对标准周期信号进行采样；分别获得所述ECG采样模块和所述PPG采样模块对所述标准周期信号的采样频率和采样结束时间；若所述ECG采样模块对所述标准周期信号的采样频率偏差超过预设频率阈值，则对所述ECG采样模块的采样频率进行补偿，以使所述ECG采样模块对所述标准周期信号的采样频率偏差低于预设频率阈值；若所述PPG采样模块对所述标准周期信号的采样频率偏差超过预设频率阈值，则对所述PPG采样模块的采样频率进行补偿，以使所述PPG采样模块对所述标准周期信号的采样频率偏差低于预设频率阈值；若所述ECG采样模块和所述PPG采样模块对所述标准周期信的采样结束时间之差超过预设时间阈值，则对所述ECG采样模块或所述PPG采样模块的采样开始时间进行补偿，以使所述ECG采样模块和所述PPG采样模块对所述标准周期信号的采样结束时间之差低于预设时间阈值。
  14. 根据权利要求13所述的系统，其特征在于，还包括：时钟模块，用于生成高精度时钟信号，所述高精度时钟信号的精度比所述ECG采样模块和所述PPG采样模块中的时钟信号的精度高一个数量级；
    所述处理器，具体用于根据所述高精度时钟信号控制所述ECG采样模块和所述PPG采样模块同时所述标准周期信号进行采样；根据所述高精度时钟信号记录所述ECG采样模块和所述PPG采样模块对所述标准周期信号的采 样结束时间。
  15. 根据权利要求14所述的系统，其特征在于，所述时钟模块，包括：高精度系统晶振、蓝牙模块中的时钟模块、无线保真WiFi模块中的时钟模块中的任一种；
    所述高精度时钟信号由高精度系统晶振、蓝牙模块的同步校准时钟信号、WiFi模块的同步校准时钟信号中的任一种生成；
    所述高精度时钟信号包括：
    正弦波信号、三角波信号、锯齿波信号中的任一种。
  16. 根据权利要求14或15所述的系统，其特征在于，所述处理器，还用于根据所述高精度时钟信号生成所述标准周期信号。
  17. 根据权利要求13～16任一项所述的系统，其特征在于，所述处理器，具体用于控制所述ECG采样模块对所述标准周期信号进行采样，计算采样后的数据的频率f1；控制所述PPG采样模块对所述标准周期信号进行采样，计算采样后的数据的频率f2；计算△f10＝|f1-f0|，△f20＝|f2-f0|，其中f0为所述标准周期信号的频率，△f10为所述ECG采样模块对所述标准周期信号的采样频率偏差，△f20为所述PPG采样模块对所述标准周期信号的采样频率偏差；若△f10>F0，且f1>f0，则减少所述ECG采样模块进行采样的数据个数L，(△f10-F0)≤L≤△f10，将(F1-L)作为所述ECG采样模块的新的采样频率，其中F1为所述ECG采样模块的原始采样频率，F0为预设频率阈值；若△f10>F0，且f1<f0，则增加所述ECG采样模块进行采样的数据个数M，(△f10-F0)≤M≤△f10，将(F1+M)作为所述ECG采样模块的新的采样频率；若△f20>F0，且f2>f0，则减少所述PPG采样模块进行采样的数据个数N，(△f20-F0)≤N≤△f20，将(F2-N)作为所述PPG采样模块的新的采样频率，其中F2为所述PPG采样模块的原始采样频率；若△f20>F0，且f2<f0，则增加所述PPG采样模块进行采样的数据个数P，(△f20-F0)≤P≤△f20，将(F2+P)作为所述PPG采样模块的新的采样频率。
  18. 根据权利要求13～17任一项所述的系统，其特征在于，所述处理器，具体用于计算所述ECG采样模块和所述PPG采样模块对所述标准周期信的采样结束时间之差△t21，△t21＝|t2-t1|，t1为所述ECG采样模块对所述标准周期信的采样结束时间，t2为所述PPG采样模块对所述标准周期信的采样结束时间；若△t21>T0，且t2>t1，则延迟所述ECG采样模块的采样触发时间tp1，且满 足T0<|tp1-tp2|<△t21，tp2为所述PPG采样模块的采样触发时间，T0为所述预设时间阈值；若△t21>T0，且t2<t1，则延迟所述PPG采样模块的采样触发时间tp2，且满足T0<|tp1-tp2|<△t21。
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Families Citing this family (3)

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Publication number Priority date Publication date Assignee Title
CN113450900A (zh) * 2020-03-25 2021-09-28 西安理邦科学仪器有限公司 生理数据的采样率确定方法、显示方法、设备及存储装置
TWI729808B (zh) * 2020-05-14 2021-06-01 廣達電腦股份有限公司 聽診裝置及應用聽診裝置的聽診方法
CN114145725B (zh) * 2022-02-08 2022-05-06 广东工业大学 一种基于无创连续血压测量的ppg采样率估算方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1582845A (zh) * 2003-08-22 2005-02-23 香港中文大学 采用温度补偿的基于光电容积描记信号的血压测量方法
CN1698536A (zh) * 2004-05-20 2005-11-23 香港中文大学 采用自动补偿的无袖带式连续血压测量方法
CN101484068A (zh) * 2006-07-05 2009-07-15 皇家飞利浦电子股份有限公司 可穿戴式血压监测系统
US20110066044A1 (en) * 2009-09-15 2011-03-17 Jim Moon Body-worn vital sign monitor
CN102186411A (zh) * 2008-10-16 2011-09-14 萨比尔医疗有限公司 用于非创伤的测量血压的系统和装置
US20150313486A1 (en) * 2014-05-02 2015-11-05 Xerox Corporation Determining pulse wave transit time from ppg and ecg/ekg signals

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4676253A (en) 1985-07-18 1987-06-30 Doll Medical Research, Inc. Method and apparatus for noninvasive determination of cardiac output
AU2002239060B1 (en) 2002-03-25 2003-10-08 Mitsubishi Denki Kabushiki Kaisha Electronic watthour meter and power-associated quantity calculating circuit
CN100471035C (zh) 2004-06-03 2009-03-18 电子科技大学 一种石英晶体振荡器温度补偿方法
CN201142678Y (zh) 2007-11-29 2008-10-29 山东电力研究院 基于锁相环的交错同步采样实时补偿装置
CN100586366C (zh) 2008-04-17 2010-02-03 胡梦辰 腕带式人体血压无创连续检测装置
CN101958726B (zh) 2009-07-13 2013-06-05 厦门胜华通信技术有限公司 Wcdma选频器中温度补偿消除频偏的方法及装置
CN101947111B (zh) 2010-09-30 2012-09-05 深圳市理邦精密仪器股份有限公司 一种输出极化电压信号的心电模拟装置及方法
CN102478422A (zh) 2010-11-23 2012-05-30 上海诚佳电子科技有限公司 一种零漂模拟校准方法及装置
CN102058400B (zh) * 2011-01-24 2012-08-22 北京新兴阳升科技有限公司 一种人体基本生命体征数据的快速检测装置
CN102857196B (zh) 2011-06-29 2016-12-07 南京中兴新软件有限责任公司 一种动态补偿晶体频偏的方法及系统
CN103248593B (zh) 2012-02-09 2017-11-07 泰凌微电子（上海）有限公司 频偏估计与消除方法及系统
CN103516654B (zh) 2012-06-20 2017-04-12 华为技术有限公司 频偏估计方法及系统
CA2894944A1 (en) * 2012-12-13 2014-06-19 Cnv Systems Ltd. System for measurement of cardiovascular health
CN105007809B (zh) 2013-02-26 2017-06-13 株式会社村田制作所 脉搏波传播时间测量装置
US10039463B1 (en) * 2013-06-27 2018-08-07 Vital Connect, Inc. Signal quality metric for cardiovascular time series
CN104095655A (zh) 2014-07-22 2014-10-15 唐洪玉 一种智能体征监测腕式可穿戴设备及血压测量方法
CN104257371A (zh) 2014-10-13 2015-01-07 天津工业大学 一种桡动脉动态血压检测及校准方法的研究
CN104856661A (zh) 2015-05-11 2015-08-26 北京航空航天大学 一种基于舒张压动态补偿的可穿戴式连续血压估测系统及方法
CN108348178B (zh) * 2015-11-26 2021-01-05 华为技术有限公司 一种血压参数检测方法及用户终端
CN106028272B (zh) 2016-07-25 2019-06-14 广东乐心医疗电子股份有限公司 基于分布式ble通信协议无线传感系统时间同步方法与装置
US10485433B2 (en) * 2016-12-29 2019-11-26 Intel Corporation Reliable estimation of pulse transit time in motion for cuffless blood pressure estimation

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1582845A (zh) * 2003-08-22 2005-02-23 香港中文大学 采用温度补偿的基于光电容积描记信号的血压测量方法
CN1698536A (zh) * 2004-05-20 2005-11-23 香港中文大学 采用自动补偿的无袖带式连续血压测量方法
CN101484068A (zh) * 2006-07-05 2009-07-15 皇家飞利浦电子股份有限公司 可穿戴式血压监测系统
CN102186411A (zh) * 2008-10-16 2011-09-14 萨比尔医疗有限公司 用于非创伤的测量血压的系统和装置
US20110066044A1 (en) * 2009-09-15 2011-03-17 Jim Moon Body-worn vital sign monitor
US20150313486A1 (en) * 2014-05-02 2015-11-05 Xerox Corporation Determining pulse wave transit time from ppg and ecg/ekg signals

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
YANG, FEIFE ET AL., RESEARCH AND IMPLEMENTATION OF WIRELESS SYNCHRONIZATION ACQUISITION SYSTEM FOR MULTI-CHANNEL PHYSIOLOGICAL SIGNALS, 31 December 2015 (2015-12-31), pages 25 - 32 *

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