WO2018041264A1 - Papier test de criblage, et système de vérification et procédé associé - Google Patents

Papier test de criblage, et système de vérification et procédé associé Download PDF

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Publication number
WO2018041264A1
WO2018041264A1 PCT/CN2017/100479 CN2017100479W WO2018041264A1 WO 2018041264 A1 WO2018041264 A1 WO 2018041264A1 CN 2017100479 W CN2017100479 W CN 2017100479W WO 2018041264 A1 WO2018041264 A1 WO 2018041264A1
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WIPO (PCT)
Prior art keywords
screening
test paper
color
area
screening test
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PCT/CN2017/100479
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English (en)
Chinese (zh)
Inventor
柯正浩
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柯正浩
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Publication of WO2018041264A1 publication Critical patent/WO2018041264A1/fr

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry

Definitions

  • the invention relates to a screening test paper, in particular to a screening test paper which can be transmitted through spectral analysis and a system and method for the inspection thereof.
  • Fig. 1 is a schematic view of a conventional screening test paper on which a reaction zone 11 is disposed.
  • the reaction zone 11 chemically reacts with the sample to change the color of the reaction zone 11.
  • the user can analyze the normality of the sample according to the color change of the reaction zone and the contrast color.
  • the screening test paper 10 has the function of screening, it does not have any indication for identification. If there are many types of screening test papers, the user is very easily confused, and misuse of contrast colors may occur. Phenomenon, the result of misjudgment, is therefore difficult to use.
  • FIG. 2 is a schematic view of another conventional screening test paper.
  • the screening test paper 20 is provided with an identification area 21 and a reaction area 22.
  • the identification area 21 is a two-dimensional barcode.
  • the use of the screening test strip 20 can be known from the electronic device (not shown).
  • the reaction zone 22 chemically reacts with the sample to change the color of the reaction zone 22.
  • the user can analyze the normality of the sample according to the color change of the reaction zone and the contrast color.
  • One of the objects of the present invention is to disclose a screening test paper which, in addition to having an identification function, can effectively solve the above problem of inconvenient use.
  • a screening test paper comprising an identification area, wherein the screening function is encoded by a color coordinate model; and a correction area having a specific color for correcting an external spectrum analysis device; And a reaction zone that chemically reacts to a particular sample and changes its own color.
  • a screening test paper inspection system comprising a screening test paper having an identification area, wherein the screening function is encoded by a color coordinate model; and a correction area having a specific color; And a reaction zone, which can chemically react to a specific sample and change its own color; a spectral analysis device can perform spectroscopic correction through the calibration zone and generate color according to the identification zone and the color of the reaction zone. a dichotomy signal; and a display device that determines a screening result based on the dichotomy signal.
  • a screening test paper inspection method comprising the steps of: providing a screening test paper having an identification area, a correction area, and a reaction area, wherein the identification area is performed by a color coordinate model.
  • a screening function code the correction zone having a specific color, the reaction zone reacting to a specific sample and changing its own color; contacting a specific sample with the reaction zone; using the calibration zone to
  • the spectral analysis device performs spectroscopic correction; the spectral analysis device splits the identification region and the color of the reflected light source of the reaction region, and generates a dichotomy signal; and provides a display device, and determines a sieve according to the dichotomy signal Check the results and display the screening results on them.
  • Figure 1 is a schematic view of a conventional screening test paper.
  • Figure 2 is a schematic diagram of another conventional screening test strip.
  • Figure 3 is a schematic view of the screening test paper of the present invention.
  • Figure 4 is a color coordinate model diagram used in the present invention.
  • 5A to 5C are views showing an embodiment of the screening test paper inspection system of the present invention.
  • Figure 6 is a schematic diagram of the wavelength of the splitting light of the present invention.
  • Figure 7 is a flow chart showing the implementation of the present invention.
  • the screening test paper of the present invention mainly comprises a correction zone 31, an identification zone 32 and a reaction zone 33.
  • the correction zone 31 has a particular color and the particular color is typically white.
  • an external spectrum analyzing device 40 shown in FIG. 5A
  • receives the reflected light source of the white correction area 31 it splits and self-corrects the error to improve the accuracy of the splitting.
  • the reaction zone 33 can chemically react to a particular sample and change its own color. After receiving the reflected light source of the reaction zone 33, the external spectrum analyzing device 40 (shown in FIG. 5A) performs splitting and generates a splitting signal.
  • Figure 4 is a color coordinate model diagram used in the present invention, as shown in the figure:
  • the x chromaticity coordinates correspond to the ratio of the red primary colors
  • the y chromaticity coordinates correspond to the proportion of the green primary colors.
  • the identification area 32 of the screening test paper 30 of the present invention performs screening function coding via a one-color coordinate model, and provides a screening function code corresponding to different samples to be tested.
  • a wide variety of screening test strips can be classified by the large number of color coordinate model codes.
  • the screening test paper inspection system of the present invention mainly comprises a screening test paper 30, a spectral analysis device 40 and a
  • the display device 50 is composed of.
  • the spectrum analyzing device 40 performs splitting according to the reflected light source of the identification area 32 on the screening test paper 30, generates a splitting signal, and transmits the splitting signal to the display device 50.
  • the display device 50 determines the type of the sample to be tested according to the split signal, and automatically sets the screening parameters.
  • the spectrum analyzing device 40 splits the reflected light source of the reaction zone 33 on the screening test paper 30 to generate a splitting signal, and transmits the split signal result to the display device 50.
  • the display device 50 compares the split signal result with the set screening parameter to determine whether the screening result of the sample to be tested is normal.
  • the test can be directly performed; if it is not determined, the user must use the correction area 31 on the screening test paper.
  • the spectral analysis device 40 performs spectroscopic correction. After the calibration is completed, the spectral analysis device 40 can be used to receive the reflected light source from the screening test strip identification area. After the splitting, the splitting result is transmitted to the display device 50 by wire or wirelessly. The display device 50 determines the type of the sample to be tested according to the type of the test test paper, and automatically sets the screening parameters.
  • the urine to be tested may be brought into contact with the reaction zone 33 of the screening test paper 30 (usually by dripping or infiltration), and the reaction zone 33 The ingredients inside will chemically react with the urine to be tested and change the color of the reaction zone 33.
  • the reaction zone 33 can include a plurality of different detection zones 331-333 for detecting glucose, protein, pH, occult blood or other physiological values in the urine to achieve the effect of screening multiple values at a time.
  • the urine to be tested is subjected to a contact reaction with the reaction zone 33 of the screening test paper 30, and the sieve test paper 30 can be placed in the spectrum analyzer 40.
  • the spectrum analyzer 40 performs spectroscopic correction according to the reflected light source of the calibration area 31 of the screening test paper 30, performs splitting according to the reflected light source of the identification area 32, and transmits the splitting signal to the display device 50, and the display device 50 displays the light according to the splitting signal.
  • the color change of the reaction zone 33 may not be visible to the human eye, but after the spectroscopic analysis device 40 is split, the spectral microscopic appearance is significantly different, so the detection result is quite accurate.
  • FIG. 6 it is a schematic diagram of the wavelength of the spectroscopic wavelength of the present invention.
  • the screening test paper 30 is used for detecting the urine sugar value, it can be clearly found that the reflected light source of the reaction zone 33 is split by the spectrum analyzer 40 and has a wavelength of about 600 nm.
  • the light source has been absorbed (the urine protein is about 450nm), and the degree of absorption, that is, the height of the trough, represents the value of urine sugar.
  • the display device 50 compares the light source according to the degree of absorption of the light source having a wavelength of about 600 nm, and displays the urine sugar value and the normality according to the built-in parameters. The user can know the result of the screening through the display device 50. In this way, automatic identification and ease of use can be achieved.
  • the sample to be tested may be saliva, urine, blood or feces, etc.
  • the sample to be tested may be water (measuring heavy metal content in water), food, toxic and harmful.
  • the color coordinate model of this technology is used for coding and identification, so there is no need to worry about the lack of source code for the classification of the sample to be tested.
  • a flow chart of the implementation of the present invention is shown in the figure.
  • a screening test paper having an identification area, a correction area and a reaction area must be provided (step S1). ) for reacting with the sample to be tested.
  • the identification zone is coded by a color coordinate model, and the correction zone has a specific color, and the reaction zone can generate a chemical reaction on a specific sample, which actually causes a change in the spectrum (if determined by the human eye) Change its own color).
  • the specific sample can be brought into contact with the reaction zone (step S2), and then the spectral analysis device is subjected to spectral correction using the calibration region (step S3) to calibrate the spectral analysis device.
  • step S4 The steps S2 and S3 may be reversed. Thereafter, the identification zone and the reaction can be transmitted through the spectrum analyzer
  • the color of the reflected light source of the area is split, and a dichotomy signal is generated (step S4), which respectively represents the detection item and the detection result of the screening test paper, and finally a display device is provided, and a screening result is determined according to the dichotomy signal. And the screening result is displayed thereon (step S5), and the screening operation is completed.
  • the reason why the spectrum analysis device currently on the market cannot analyze the wavelengths of all the light sources is that the spectral separation effect is not satisfactory, and the reason why the spectral separation effect is not satisfactory is that the components in the spectrum analysis device are mostly not system-on-chip (SOC).
  • SOC system-on-chip
  • the spectrum analyzing device 40 of the present invention is realized by a system chip (SOC), and its internal components (reflected light receiving portion and grating, etc.) utilize a wavelength range of between 0.01 nm and 100 nm.
  • the unexposed photoresist layer is removed.
  • the spectral analysis device 40 can be reduced in size, but also the surface roughness can be reduced, so that the reflected light source can be totally reflected without being attenuated, thereby achieving the effect of complete splitting.

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  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Spectrometry And Color Measurement (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L'invention concerne un papier (30) test de criblage qui comprend une zone de reconnaissance (32) servant à coder une fonction de criblage au moyen d'un modèle de coordonnées de couleur ; une zone d'étalonnage (31) présentant une couleur spécifique et servant à étalonner un dispositif d'analyse (40) de spectre externe ; et une zone de réaction (33), capable de réagir chimiquement à un spécimen spécifique et de changer de couleur. Au moyen du dispositif d'analyse (40) de spectre externe mettant en oeuvre un traitement de division de lumière sur une source de lumière réfléchie de la zone de reconnaissance (32) et de la zone de réaction (33) sur le papier (30) test de criblage, l'invention permet d'obtenir un effet de reconnaissance automatique, et est simple et pratique à utiliser.
PCT/CN2017/100479 2016-09-05 2017-09-05 Papier test de criblage, et système de vérification et procédé associé WO2018041264A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201610801332.9A CN107796806A (zh) 2016-09-05 2016-09-05 筛检试纸及其检验之系统与方法
CN201610801332.9 2016-09-05

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110596084A (zh) * 2019-08-26 2019-12-20 江苏大学 一种检测汞离子的荧光试纸及检测方法

Families Citing this family (5)

* Cited by examiner, † Cited by third party
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CN112534242A (zh) * 2019-02-15 2021-03-19 柯正浩 筛检试纸读取系统
CN110609034A (zh) * 2019-10-08 2019-12-24 民康医疗科技（天津）有限公司 自动识别试纸code码的方法
JP7488775B2 (ja) * 2020-08-20 2024-05-22 チェン・ハオ コー， 検査用試験紙読取システム
CN114739991B (zh) * 2022-06-09 2022-09-02 博奥生物集团有限公司 一种尿干化学常规检测方法及检测装置
WO2024026853A1 (fr) * 2022-08-05 2024-02-08 柯正浩 Méthode de lecture et de mesure de test de dépistage à partir d'une bandelette réactive

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US5945341A (en) * 1996-10-21 1999-08-31 Bayer Corporation System for the optical identification of coding on a diagnostic test strip
JP2002228658A (ja) * 2001-02-06 2002-08-14 Omron Corp 分析装置
CN1455240A (zh) * 2002-05-01 2003-11-12 生命扫描有限公司 用于测定分析物浓度的装置和方法
CN101614672A (zh) * 2009-07-21 2009-12-30 北京智云达科技有限公司 一种便携式可扩展的试纸分析方法及其设备
US20100012490A1 (en) * 2008-07-15 2010-01-21 Tien-Tsai Hsu Test strip with optical identification patterns and test instrument using the same
CN104964973A (zh) * 2015-07-08 2015-10-07 邓双胜 一种基于移动终端摄像头的试纸读取与分析方法与系统

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US9715050B2 (en) * 2011-11-25 2017-07-25 Cheng-Hao KO Optical wavelength dispersion device and method of manufacturing the same
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US5945341A (en) * 1996-10-21 1999-08-31 Bayer Corporation System for the optical identification of coding on a diagnostic test strip
JP2002228658A (ja) * 2001-02-06 2002-08-14 Omron Corp 分析装置
CN1455240A (zh) * 2002-05-01 2003-11-12 生命扫描有限公司 用于测定分析物浓度的装置和方法
US20100012490A1 (en) * 2008-07-15 2010-01-21 Tien-Tsai Hsu Test strip with optical identification patterns and test instrument using the same
CN101614672A (zh) * 2009-07-21 2009-12-30 北京智云达科技有限公司 一种便携式可扩展的试纸分析方法及其设备
CN104964973A (zh) * 2015-07-08 2015-10-07 邓双胜 一种基于移动终端摄像头的试纸读取与分析方法与系统

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110596084A (zh) * 2019-08-26 2019-12-20 江苏大学 一种检测汞离子的荧光试纸及检测方法
EP3812746A4 (fr) * 2019-08-26 2021-09-01 Jiangsu University Papier réactif fluorescent destiné à mesurer des ions mercure et procédé de mesure
CN110596084B (zh) * 2019-08-26 2024-06-07 江苏大学 一种检测汞离子的荧光试纸及检测方法

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