WO2018036211A1 - Appareil de compensation de dérive de température et procédé de mesure de micro-signaux - Google Patents

Appareil de compensation de dérive de température et procédé de mesure de micro-signaux Download PDF

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Publication number
WO2018036211A1
WO2018036211A1 PCT/CN2017/084229 CN2017084229W WO2018036211A1 WO 2018036211 A1 WO2018036211 A1 WO 2018036211A1 CN 2017084229 W CN2017084229 W CN 2017084229W WO 2018036211 A1 WO2018036211 A1 WO 2018036211A1
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Prior art keywords
signal
differential amplifier
micro
resistor
differential
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PCT/CN2017/084229
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English (en)
Chinese (zh)
Inventor
张贯京
高伟明
唐昭月
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深圳市前海安测信息技术有限公司
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Publication of WO2018036211A1 publication Critical patent/WO2018036211A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/0205—Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
    • A61B5/02055—Simultaneously evaluating both cardiovascular condition and temperature
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/0205—Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/024—Detecting, measuring or recording pulse rate or heart rate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7225—Details of analog processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
    • G05B19/00—Programme-control systems
    • G05B19/02—Programme-control systems electric
    • G05B19/04—Programme control other than numerical control, i.e. in sequence controllers or logic controllers
    • G05B19/042—Programme control other than numerical control, i.e. in sequence controllers or logic controllers using digital processors
    • H—ELECTRICITY
    • H03—ELECTRONIC CIRCUITRY
    • H03F—AMPLIFIERS
    • H03F3/00—Amplifiers with only discharge tubes or only semiconductor devices as amplifying elements
    • H03F3/68—Combinations of amplifiers, e.g. multi-channel amplifiers for stereophonics

Definitions

  • the present invention relates to the technical field of signal measurement, and more particularly to a temperature drift compensation apparatus and method for measuring a micro signal.
  • micro signals The amplification of micro signals is the basis of signal measurement and measurement. For small signals within 50mV, it cannot be directly used for chips such as AD sampling. The signal must be amplified by the amplifier circuit before it can be measured. Micro-signal measurement is often a difficult point in signal measurement, and small signals within 50mV are difficult to detect by signal measurement circuits. Generally, bioelectrical signals output by biosensors (such as blood glucose, body temperature, heart rate biosensors, etc. in vital signs monitoring biosensors) are relatively weak. Since the bioelectrical signals to be measured are weak, the bioelectricity to be measured must be measured by an amplifying circuit. The signal can only be measured after it has been amplified.
  • biosensors such as blood glucose, body temperature, heart rate biosensors, etc. in vital signs monitoring biosensors
  • the amplifying circuit in the existing signal measuring device amplifies the weak signal, and the amplifying circuit often generates a temperature drift phenomenon and causes strong signal interference, so that the weak bioelectric signal is submerged in the interference signal, thus causing The measurement result of the weak measured bioelectrical signal is inaccurate, and even the weak measured bioelectrical signal cannot be measured.
  • a main object of the present invention is to provide a temperature drift compensation apparatus and method for measuring a micro signal, which aims to solve the problem that the measurement result is inaccurate in measuring a weak signal due to a temperature drift generated by the amplification circuit.
  • the present invention provides a temperature drift compensation device for measuring a micro signal, which is connected with a first biosensor, a second biosensor, a third biosensor, and a fourth biosensor.
  • the temperature drift compensation device includes a first differential amplifier, a second differential amplifier, a third differential amplifier, an ADC amplification chip, and a single chip microcomputer, and the first differential amplifier and the second differential amplifier each include two first resistors and two second a resistor, the third differential amplifier includes two third a resistor and two fourth resistors, wherein:
  • the first differential op amp is configured to acquire a first micro signal from a first biosensor and acquire a second micro signal from a second biosensor, and pass the first micro signal and the second micro signal through the first differential
  • the amplification factor of the op amp is differentially operated and amplified to obtain a first differential signal
  • the second differential amplifier is configured to acquire a third micro signal from a third biosensor and acquire a fourth micro signal from a fourth biosensor, and pass the third differential signal and the fourth micro signal through the second differential amplifier
  • the amplification is performed by a differential operation and amplified to obtain a second differential signal
  • the third differential amplifier is configured to perform differential operation on the first differential signal and the second differential signal by using a magnification of the third differential amplifier, and amplify the measured characteristic signal;
  • the ADC amplifying chip includes an amplifying circuit chip and an ADC circuit chip, and the amplifying circuit chip is configured to amplify the measured characteristic signal by amplifying the amplification circuit chip and output the signal to the AD.
  • the temperature coefficient of the first differential amplifier is equal to a ratio of a temperature coefficient of the second resistor to a temperature coefficient of the first resistor
  • a temperature coefficient of the second differential amplifier is equal to a temperature coefficient of the first differential amplifier
  • the third differential amplifier The temperature coefficient is equal to the ratio of the temperature coefficient of the fourth resistor to the temperature coefficient of the third resistor
  • the product of the temperature coefficient of the first differential amplifier and the temperature coefficient of the third differential amplifier is equal in magnitude and opposite in sign to the temperature coefficient of the amplifying circuit chip.
  • the first input end of the first differential amplifier is connected to the first biosensor, the second input end of the first differential amplifier is connected to the second biosensor; the first input of the second differential amplifier Connected to the third biosensor, the second input of the second differential amplifier is connected to the fourth biosensor; the output of the first differential amplifier is connected to the first input of the third differential amplifier, the second differential amplifier The output end is connected to the second input end of the third differential amplifier; the output end of the third differential amplifier is connected to the input end of the amplifying circuit chip, and the output end of the amplifying circuit chip is connected to the input end of the ADC circuit chip The output end of the ADC circuit chip is connected to the single chip microcomputer.
  • the first differential amplifier further includes a first transistor, and one of the first resistors of the first differential amplifier is connected in series to the first transistor. a first input, the other one of the first differential amplifiers being connected in series to the second of the first transistor Wherein the end of the first differential amplifier One end of a second resistor is connected to the first input end of the first transistor and the other end of the second resistor is connected to the output end of the first transistor, and one end of the other second resistor of the first differential amplifier is connected to a second input end of the first transistor and the other end of the second resistor is connected to the ground line
  • the second differential amplifier further includes a first transistor, one of the first resistors of the second differential amplifier is connected in series to the first input end of the first transistor, and the other of the second differential amplifier a resistor is connected in series to the second input end of the first transistor, one end of one of the second resistors of the second differential amplifier is connected to the first input end of the first transistor and the other end of the second resistor is connected to the first crystal An output end of the transistor, one end of the other second resistor of the second differential amplifier is connected to the second input end of the first transistor and the other end of the second resistor is connected to the ground line
  • the third differential amplifier further includes a second transistor, wherein a third resistor is connected in series to the first input end of the second transistor, and the other third resistor is connected in series to the second transistor a second input end, wherein one end of the fourth resistor is connected to the first input end of the second transistor and the other end of the fourth resistor is connected to the output end of the second transistor, wherein one end of the other fourth resistor is connected to The second input of the second transistor and the other end of the fourth resistor are connected to the ground line.
  • the ADC circuit chip is configured to perform digital-to-analog conversion on the amplified measurement characteristic signal and output the signal to the single-chip microcomputer for signal measurement and analysis.
  • the first biosensor is configured to sense a first micro-signal generated by the first wavelength infrared light to be irradiated on the target detection object
  • the second biosensor is configured to sense the second wavelength infrared light to be irradiated on the target Detecting a second micro signal generated on the object, a third biosensor for sensing a third micro signal generated by the third wavelength infrared light on the target detection object, and a fourth biosensor for sensing the fourth wavelength infrared light irradiation A fourth microsignal generated on the target detection object.
  • the present invention further provides a temperature drift compensation method for measuring a micro signal, which is applied to a temperature drift compensation device, which is connected with a first biosensor, a second biosensor, a third biosensor and a fourth biosensor, the temperature drift compensation device comprising a first differential amplifier, a second differential amplifier, a third differential amplifier, an ADC amplification chip, and a single chip microcomputer
  • the first differential amplifier and the second differential amplifier each include two first resistors and two second resistors
  • the third differential amplifier includes two third resistors and two fourth resistors
  • the ADC amplification chip includes an amplification circuit chip.
  • an ADC circuit chip wherein the temperature drift compensation method for measuring the micro signal comprises the following steps:
  • the first differential op amp acquires a first micro signal from a first biosensor and a second micro signal from a second biosensor;
  • the first differential op amp performs differential operation on the first micro-signal and the second micro-signal through an amplification factor of the first differential op amp and amplifies the first differential signal;
  • the second differential amplifier acquires a third micro signal from a third biosensor and obtains a fourth micro signal from a fourth biosensor;
  • the second differential amplifier performs differential operation on the third micro signal and the fourth micro signal by amplifying the amplification of the second differential amplifier to obtain a second differential signal;
  • the third differential amplifier performs differential operation on the first differential signal and the second differential signal by the amplification factor of the third differential amplifier and amplifies the measured characteristic signal
  • the amplifying circuit chip amplifies the measured characteristic signal by amplifying the amplification circuit chip, and outputs the signal to the ADC circuit chip;
  • the temperature coefficient of the first differential amplifier is equal to a ratio of a temperature coefficient of the second resistor to a temperature coefficient of the first resistor
  • a temperature coefficient of the second differential amplifier is equal to a temperature coefficient of the first differential amplifier
  • the third differential amplifier The temperature coefficient is equal to the ratio of the temperature coefficient of the fourth resistor to the temperature coefficient of the third resistor
  • the product of the temperature coefficient of the first differential amplifier and the temperature coefficient of the third differential amplifier is equal in magnitude and opposite in sign to the temperature coefficient of the amplifying circuit chip.
  • the first micro signal is that the first biosensor senses the characteristic electric signal generated by the first wavelength infrared light irradiation on the target detection object
  • the second micro signal is that the second biosensor senses the second The two-wavelength infrared light illuminates the characteristic electric signal generated on the target detection object
  • the third micro-signal is that the third bio-sensor senses the characteristic electric signal generated by the third-wavelength infrared light irradiation on the target detection object
  • the fourth micro-signal is The fourth biosensor senses the characteristic electric signal generated by the fourth wavelength infrared light on the target detection object.
  • the ADC amplification chip further includes an ADC circuit chip, and the method is used for measuring the temperature of the micro signal.
  • the degree drift compensation method further includes the following steps: the ADC circuit chip performs digital-to-analog conversion on the amplified measurement characteristic signal and outputs the signal to the single-chip microcomputer for signal measurement and analysis.
  • the temperature drift compensation device and method for measuring micro signals according to the present invention adopt the above technical solution, and obtain the following technical effects: by acquiring four weak characteristic electrical signals and passing through The differential amplifier performs differential operation and performs high-magnification amplification to obtain the measured characteristic signal, so that the weak characteristic electrical signal can be measured.
  • the influence of the temperature drift generated by the multi-stage differential amplifier on the weak signal interference cancels out the temperature generated by the amplifying circuit chip itself.
  • the influence of drift on weak signal interference can eliminate the signal interference caused by the temperature drift of the weak signal in the signal amplification of the high-magnification amplifier circuit, and improve the accuracy of measuring the weak signal.
  • FIG. 1 is a schematic diagram showing the circuit configuration of a preferred embodiment of a temperature drift compensating apparatus for measuring micro signals according to the present invention
  • FIG. 2 is a flow chart of a method of a preferred embodiment of a temperature drift compensation method for measuring micro signals according to the present invention.
  • FIG. 1 is a schematic diagram showing the circuit structure of a preferred embodiment of a temperature drift compensating apparatus for measuring micro signals according to the present invention.
  • the temperature drift compensation device 1 includes, but is not limited to, a first differential amplifier 11, a second differential amplifier 12, a third differential amplifier 13, an ADC (digital-to-analog conversion) amplifier chip 14, and a single chip microcomputer 15.
  • the first input of the first differential amplifier 11 is connected to the first bio-transmit
  • the sensor 2 the second input of the first differential amplifier 11 is connected to the second biosensor 3
  • the first input of the second differential amplifier 12 is connected to the third biosensor 4, and the second input of the second differential amplifier 12 Connected to the fourth biosensor 5.
  • the output of the first differential amplifier 11 is connected to the first input of the third differential amplifier 13, and the output of the second differential amplifier 12 is connected to the second input of the third differential amplifier 13, the output of the third differential amplifier 13.
  • the ADC amplifying chip 14 is connected to the microcontroller 15.
  • the first biosensor 2 is for acquiring a first micro signal from a target detection object
  • the second biosensor 3 is for acquiring a second micro signal from a target detection object
  • the third biosensor 4 is for detecting a target object from a target
  • the third micro-signal is acquired
  • the fourth biosensor 5 is configured to acquire the fourth micro-signal from the target detection object.
  • the first micro signal is that the first biosensor 2 senses that the first wavelength infrared light is generated on the target detection object.
  • the second micro signal is that the second biosensor 3 senses a characteristic electric signal generated by the second wavelength infrared light on the target detection object
  • the third micro signal is that the third biosensor 4 senses the third
  • the wavelength infrared light illuminates the characteristic electrical signal generated on the target detection object
  • the fourth micro signal is the fourth electrical sensor 5 senses the characteristic electric signal generated by the fourth wavelength infrared light irradiation on the target detection object.
  • four kinds of micro signals which are irradiated to the target detection object by infrared light of four different wavelengths are obtained, and the measurement characteristic signals of the target detection object are measured by performing multi-level differential operation on the four kinds of micro signals and amplifying.
  • the temperature drift compensating device 1 performs multi-stage differential operation and amplifies to obtain a blood glucose concentration signal of the human body, and outputs the signal to the single-chip microcomputer 5 for subsequent blood glucose concentration analysis.
  • the first differential amplifier 11 and the second differential amplifier 12 each include two first resistors R1, two second resistors R2, and a first transistor Q1.
  • One of the first resistors R1 of the first differential amplifier 11 is connected in series to the first input terminal of the first transistor Q1, and the other one of the first resistors R1 of the first differential amplifier 11 is connected in series to the second input terminal of the first transistor Q1.
  • One end of one of the second resistors R2 of the first differential amplifier 11 is connected to the first input end of the first transistor Q1 and the other end of the second resistor R2 is connected to the output end of the first transistor Q1, the first difference One end of the other second resistor R2 of the amplifier 11 is connected to the second input terminal of the first transistor Q1 and the second resistor The other end of R2 is connected to the ground wire.
  • One of the first resistors R1 of the second differential amplifier 12 is connected in series to the first input terminal of the first transistor Q1, and the other one of the first resistors R1 of the second differential amplifier 12 is connected in series to the second input terminal of the first transistor Q1.
  • One end of one of the second resistors R 2 of the second differential amplifier 12 is connected to the first input end of the first transistor Q1 and the other end of the second resistor R2 is connected to the output end of the first transistor Q1, the second One end of the other second resistor R2 of the differential amplifier 12 is connected to the second input terminal of the first transistor Q1 and the other end of the second resistor R2 is connected to the ground line.
  • the first differential op amp 11 is configured to acquire a first micro signal from the first biosensor 2 and acquire a second micro signal from the second biosensor 3, and pass the first micro signal and the second micro signal through the first
  • the amplification of a differential op amp 11 is differentially operated and amplified to obtain a first differential signal.
  • the second differential amplifier 12 is configured to acquire a third micro signal from the third biosensor 4 and acquire a fourth micro signal from the fourth biosensor 5, and pass the third differential signal and the fourth micro signal through the second differential amplifier
  • the amplification of 12 is differentially operated and amplified to obtain a second differential signal.
  • the amplification factor of the first differential amplifier 11 is equal to the ratio of the resistance of the second resistor R2 in the first differential amplifier 11 and the first resistor R1, and the amplification factor of the second differential amplifier 12 is equal to the amplification factor of the first differential amplifier 11.
  • the temperature coefficient K1 of the first differential amplifier 11 is determined by the temperature coefficient of the second resistor R2 and the first resistor R1 in the first differential amplifier 11. It can be understood that the temperature coefficient of the one resistor refers to the relative change value of the resistance value of the resistor when the temperature changes by 1 ° C, and the unit is ppm : .
  • the temperature coefficient usually uses the average temperature coefficient, and has a negative temperature coefficient, a positive temperature coefficient, and a critical temperature coefficient at which the resistance will only abrupt at a certain temperature.
  • the temperature coefficient of the second differential amplifier 12 is equal to the temperature coefficient of the first differential amplifier 11
  • the third differential amplifier 13 includes two third resistors R3, two fourth resistors R4, and one second transistor Q2.
  • One of the third resistors R3 of the third differential amplifier 13 is connected in series to the first input terminal of the second transistor Q2, wherein the other third resistor R3 is connected in series to the second input terminal of the second transistor Q2; the third differential amplifier 13 One end of the fourth resistor R4 is connected to the first input end of the second transistor Q2 and the other end of the fourth resistor R4 is connected to the output end of the second transistor Q2, wherein one end of the other fourth resistor R4 Connected to the second input terminal of the second transistor Q2 and the other end of the fourth resistor R4 is connected to the ground line.
  • the third differential amplifier 13 is configured to perform differential operation on the first differential signal and the second differential signal by the amplification factor of the third differential amplifier 13 and amplify the measured characteristic signal.
  • the amplification factor of the third differential amplifier 13 is equal to the ratio of the resistance values of the fourth resistor R4 and the third resistor R3 in the third differential amplifier 13.
  • the temperature coefficient K2 of the third differential amplifier 13 is determined by the temperature coefficients of the fourth resistor R4 and the third resistor R3 in the third differential amplifier 13.
  • QCR3 is the temperature of the third resistor R3.
  • the coefficient, QCR4 is the temperature coefficient of the fourth resistor R4, ? T is the temperature change value, ? R3 is the resistance change value of the third resistor R3 under temperature change, ? R4 is the resistance change value of the fourth resistor R4 under temperature change, / represents the division operation, ? Represents multiplication.
  • the ADC amplification chip 14 includes, but is not limited to, an amplification circuit chip 141 and an ADC circuit chip 142.
  • the input end of the amplifying circuit chip 141 is connected to the output end of the third differential amplifier 13.
  • the output end of the amplifying circuit chip 141 is connected to the input end of the ADC circuit chip 142, and the output end of the ADC circuit chip 142 is connected to The single chip microcomputer 15.
  • the amplifying circuit chip 141 is configured to amplify the measured characteristic signal by the amplification factor of the amplifying circuit chip 141 and output the signal to the ADC circuit chip 142.
  • the ADC circuit chip 142 is configured to count the amplified measured characteristic signals. The mode is converted and output to the microcontroller 15 for subsequent signal measurement analysis.
  • the amplifying circuit chip 141 is composed of an amplifying circuit in the prior art
  • the AD C circuit chip 142 is composed of a digital-to-analog converting circuit in the prior art.
  • the amplification factor of the amplifying circuit chip 141 is an inherent specific value of the amplifying circuit chip 141. That is, the amplification property inherent to the amplifying circuit chip 141 is affected by the temperature drift caused by the temperature coefficient K3 of the amplifying circuit chip 141 during operation.
  • the temperature coefficient K3 of the amplifying circuit chip 141 is a temperature characteristic inherent to the amplifying circuit chip 141, which reflects the severity of temperature drift of the amplifying circuit chip 141 when the amplifying circuit chip 141 changes in operating temperature.
  • the amplifying circuit chip 141 generates a temperature drift phenomenon as a function of the operating temperature, causing a signal interference with the measurement characteristic signal, thereby causing the measurement characteristic signal to be submerged in the interference signal, and thus the measurement characteristic signal cannot be accurately measured.
  • the temperature coefficient of the fourth resistor R4 is such that the product of the temperature coefficient K1 of the first differential amplifier 11 and the temperature coefficient K2 of the third differential amplifier 13 is equal in magnitude and opposite in sign to the temperature coefficient K3 of the amplifying circuit chip 141, thus making the first
  • the influence of the temperature drift generated by the differential amplifier 11 and the third differential amplifier 13 on the signal interference and the influence of the temperature drift generated by the amplifying circuit chip 141 on the signal interference cancel each other, thereby eliminating the signal amplification of the weak signal in the high-magnification amplifier circuit. Signal interference caused by temperature drift encountered, improving the accuracy of measuring weak signals.
  • the present invention also provides a temperature drift compensation method for measuring a micro signal, which is applied to the temperature drift compensation device 1 shown in FIG.
  • FIG. 2 is a flow chart of a method of a preferred embodiment of the temperature drift compensation method for measuring micro signals according to the present invention.
  • the temperature drift compensation method includes steps S21 to S27.
  • Step S21 the first differential amplifier acquires the first micro signal from the first biosensor and acquires the second micro signal from the second biosensor; specifically, the first differential op amp 11 acquires the first biosensor 2 A microsignal and a second microsignal is obtained from the second biosensor 3.
  • the first micro signal is that the first biosensor 2 senses a characteristic electric signal generated by the first wavelength infrared light being irradiated on the target detection object, and the second micro signal is sensed by the second biosensor 3 The second wavelength infrared light is irradiated to illuminate the characteristic electrical signal generated on the target detection object.
  • Step S22 the first differential amplifier performs differential operation on the first micro signal and the second micro signal by using the amplification factor of the first differential op amp 11 to obtain a first differential signal.
  • the first differential op amp The first and second micro signals are differentially operated by the amplification of the first differential op amp 11 and amplified to obtain a first differential signal.
  • the magnification of the first differential op amp 11 is equal to the first differential
  • the ratio of the resistance of the second resistor R2 in the amplifier 11 to the resistance of the first resistor R1 is affected by the temperature drift of the temperature coefficient K1 of the first differential amplifier 11.
  • the temperature coefficient K1 of the first differential amplifier 11 is determined by the temperature coefficient of the second resistor R2 and the first resistor R1 in the first differential amplifier 11.
  • QCR1 is the temperature of the first resistor R1.
  • the coefficient, QCR2 is the temperature coefficient of the second resistor R2
  • ? T is the temperature change value
  • ? R1 is the change in resistance of the first resistor R1 under temperature change
  • ? R2 is the resistance change value of the second resistor R2 under temperature change
  • / represents the division operation
  • the temperature coefficient usually uses the average temperature coefficient, and has a negative temperature coefficient, a positive temperature coefficient, and a critical temperature coefficient at which the resistance will only abrupt at a certain temperature.
  • Step S23 the second differential amplifier acquires the third micro signal from the third biosensor and acquires the fourth micro signal from the fourth biosensor; specifically, the second differential amplifier 12 acquires the third micro from the third biosensor 4.
  • the signal and the fourth micro-signal are acquired from the fourth biosensor 5.
  • the third micro signal is that the third biosensor 4 senses the characteristic electric signal generated by the third wavelength infrared light on the target detection object, and the fourth micro signal is sensed by the fourth biosensor 5
  • the fourth wavelength infrared light is irradiated to illuminate the characteristic electrical signal generated on the target detection object.
  • Step S24 the second differential amplifier performs differential operation on the third micro signal and the fourth micro signal by using the amplification factor of the second differential amplifier, and amplifies the second differential signal; specifically, the second differential amplifier 12
  • the third micro signal and the fourth micro signal are differentially operated by the amplification factor of the second differential amplifier 12 and amplified to obtain a second differential signal.
  • the amplification factor of the second differential amplifier 12 is equal to the amplification factor of the first differential amplifier 11.
  • Step S25 the third differential amplifier performs differential operation on the first differential signal and the second differential signal through the second amplification factor of the third differential amplifier, and amplifies the measurement characteristic signal; specifically, the third differential amplifier 13
  • the first differential signal and the second differential signal are differentially operated by the amplification factor of the third differential amplifier 13 and amplified to obtain a measurement characteristic signal.
  • the amplification factor of the third differential amplifier 13 is equal to the ratio of the resistance values of the fourth resistor R4 and the third resistor R3 in the third differential amplifier 13, and is affected by the temperature drift caused by the temperature coefficient K2 of the third differential amplifier 13.
  • the first The temperature coefficient K2 of the triple differential amplifier 13 is determined by the temperature coefficient of the fourth resistor R4 and the third resistor R3 in the third differential amplifier 13.
  • QCR3 is the temperature of the third resistor R3.
  • the coefficient, QCR4 is the temperature coefficient of the fourth resistor R4, ? T is the temperature change value, ? R3 is the resistance change value of the third resistor R3 under temperature change, ? R4 is the resistance change value of the fourth resistor R4 under temperature change, / represents the division operation, ?
  • Step S26 the amplification circuit chip amplifies the measurement characteristic signal by the amplification factor of the amplification circuit chip, and outputs the signal to the ADC circuit chip.
  • the amplification circuit chip 141 passes the measurement characteristic signal through the amplification factor of the amplification circuit chip 141.
  • the signal is amplified and output to the ADC circuit chip 142.
  • the amplifying circuit chip 141 is composed of an amplifying circuit in the prior art
  • the AD C circuit chip 142 is composed of a digital-to-analog converting circuit in the prior art.
  • the amplification factor of the amplifying circuit chip 141 is an inherent specific value of the amplifying circuit chip 141, that is, the amplifying circuit chip 141 has an inherent amplification property, but is subjected to the amplifying circuit chip 141 during operation.
  • the temperature coefficient K3 produces the effect of temperature drift.
  • the temperature coefficient K3 of the amplifying circuit chip 141 is a temperature characteristic inherent to the amplifying circuit chip 141, which reflects the severity of temperature drift of the amplifying circuit chip 141 when the amplifying circuit chip 141 changes in operating temperature.
  • the amplifying circuit chip 141 generates a temperature drift phenomenon as a function of the operating temperature, causing a signal interference with the measurement characteristic signal, thereby causing the measurement characteristic signal to be submerged in the interference signal, and thus the measurement characteristic signal cannot be accurately measured.
  • the temperature coefficient of the fourth resistor R4 is such that the product of the temperature coefficient K1 of the first differential amplifier 11 and the temperature coefficient K2 of the third differential amplifier 13 is equal in magnitude and opposite in sign to the temperature coefficient K3 of the amplifying circuit chip 141, thus making the first
  • the influence of the temperature drift generated by the differential amplifier 11 and the third differential amplifier 13 on the weak signal interference and the influence of the temperature drift generated by the amplifying circuit chip 141 on the weak signal interference cancel each other, thereby eliminating the signal amplification of the weak signal in the high-magnification amplifier circuit. ⁇ Signal interference caused by temperature drift.
  • Step S27 the ADC circuit chip performs digital-to-analog conversion on the amplified measurement characteristic signal, and outputs the signal to the single-chip microcomputer for signal measurement and analysis.
  • the ADC circuit chip 142 performs digital-to-analog conversion on the amplified measurement characteristic signal and outputs the signal to the ADC.
  • the single chip microcomputer 15 is used for subsequent signal measurement analysis.
  • the temperature drift compensation apparatus and method for measuring micro signals can obtain a measurement characteristic signal by acquiring four weak characteristic electric signals and performing differential calculation by a multi-stage differential amplifier and performing high-magnification amplification. Measuring weak characteristic electrical signals; the effect of temperature drift caused by multi-stage differential amplifiers on weak signal interference cancels out the influence of temperature drift generated by the amplifying circuit chip itself on weak signal interference, thereby eliminating weak signals in high-magnification amplifier circuits The signal interference caused by the temperature drift encountered by the signal amplification is improved, and the accuracy of measuring the weak signal is improved.
  • the temperature drift compensation apparatus and method for measuring micro signals adopt the above technical solution, and obtain the following technical effects: by acquiring four weak characteristic electric signals and passing through The differential amplifier performs differential operation and performs high-magnification amplification to obtain the measured characteristic signal, so that the weak characteristic electrical signal can be measured.
  • the influence of the temperature drift generated by the multi-stage differential amplifier on the weak signal interference cancels out the temperature generated by the amplifying circuit chip itself.
  • the influence of drift on weak signal interference can eliminate the signal interference caused by the temperature drift of the weak signal in the signal amplification of the high-magnification amplifier circuit, and improve the accuracy of measuring the weak signal.

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Abstract

L'invention concerne un appareil de compensation de dérive de température (1) et un procédé de mesure de micro-signaux. L'appareil (1) comprend un premier amplificateur différentiel (11), un deuxième amplificateur différentiel (12), un troisième amplificateur différentiel (13), une puce d'amplification de CAN (14), et un micro-ordinateur monopuce (15). Le premier amplificateur différentiel (11) met en oeuvre un calcul différentiel et une amplification sur un premier micro-signal et un second micro-signal pour obtenir un premier signal différentiel. Le deuxième amplificateur différentiel (12) met en oeuvre un calcul différentiel et une amplification sur un troisième micro-signal et un quatrième micro-signal pour obtenir un second signal différentiel. Le troisième amplificateur différentiel (13) met en oeuvre un calcul différentiel et une amplification sur le premier signal différentiel et le second signal différentiel pour obtenir un signal de caractéristique de mesure. La puce d'amplification de CAN (14) amplifie le signal de caractéristique de mesure et délivre en sortie ensuite le signal de caractéristique de mesure amplifié au micro-ordinateur monopuce (15). Le produit d'un coefficient de température du premier amplificateur différentiel (11) et d'un coefficient de température du troisième amplificateur différentiel (13) est égal en valeur mais opposé en signe à un coefficient de température d'une puce de circuit d'amplification (141). L'appareil (1) et le procédé peuvent éliminer une interférence avec des micro-signaux provoquée par une dérive de température générée par un circuit de mesure, et améliorer la précision de mesure des micro-signaux.
PCT/CN2017/084229 2016-08-26 2017-05-12 Appareil de compensation de dérive de température et procédé de mesure de micro-signaux WO2018036211A1 (fr)

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Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN206151465U (zh) * 2016-08-26 2017-05-10 深圳市前海安测信息技术有限公司 微信号精密测量电路
CN106344039A (zh) * 2016-08-26 2017-01-25 深圳市前海安测信息技术有限公司 生物传感器的微信号精密测量装置及方法
CN106374861A (zh) * 2016-08-26 2017-02-01 深圳市前海安测信息技术有限公司 生物传感器的微信号多级放大装置及方法
CN106343974A (zh) * 2016-08-26 2017-01-25 深圳市前海安测信息技术有限公司 用于测量微信号的温度漂移补偿装置及方法
CN110806280A (zh) * 2018-08-06 2020-02-18 南京沃天科技有限公司 一种基于bp神经网络的传感器温度补偿系统及方法
CN110161838B (zh) * 2019-05-06 2020-12-15 浙江大学 带压电力传感器静态漂移自动补偿的切削力主从控制系统
CN114516486B (zh) * 2020-11-20 2024-05-14 圣邦微电子（北京）股份有限公司 芯片存储设备
CN113467320A (zh) * 2021-07-21 2021-10-01 西安龙飞电气技术有限公司 基于增益补偿的微弱信号检测算法

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060091294A1 (en) * 2004-10-29 2006-05-04 Michael Frank Apparatus and method for interference suppression in optical or radiation sensors
CN1989404A (zh) * 2004-05-28 2007-06-27 霍尼韦尔国际公司 差分热传感器
CN103026252A (zh) * 2010-07-23 2013-04-03 皇家飞利浦电子股份有限公司 用于去除互耦mri 干扰的双压力传感器信号链
CN205139762U (zh) * 2015-12-04 2016-04-06 潍坊医学院 一种平铺结构的线性差分霍尔电压发生器
CN106343974A (zh) * 2016-08-26 2017-01-25 深圳市前海安测信息技术有限公司 用于测量微信号的温度漂移补偿装置及方法
CN106344039A (zh) * 2016-08-26 2017-01-25 深圳市前海安测信息技术有限公司 生物传感器的微信号精密测量装置及方法
CN106374861A (zh) * 2016-08-26 2017-02-01 深圳市前海安测信息技术有限公司 生物传感器的微信号多级放大装置及方法
CN206151465U (zh) * 2016-08-26 2017-05-10 深圳市前海安测信息技术有限公司 微信号精密测量电路

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1989404A (zh) * 2004-05-28 2007-06-27 霍尼韦尔国际公司 差分热传感器
US20060091294A1 (en) * 2004-10-29 2006-05-04 Michael Frank Apparatus and method for interference suppression in optical or radiation sensors
CN103026252A (zh) * 2010-07-23 2013-04-03 皇家飞利浦电子股份有限公司 用于去除互耦mri 干扰的双压力传感器信号链
CN205139762U (zh) * 2015-12-04 2016-04-06 潍坊医学院 一种平铺结构的线性差分霍尔电压发生器
CN106343974A (zh) * 2016-08-26 2017-01-25 深圳市前海安测信息技术有限公司 用于测量微信号的温度漂移补偿装置及方法
CN106344039A (zh) * 2016-08-26 2017-01-25 深圳市前海安测信息技术有限公司 生物传感器的微信号精密测量装置及方法
CN106374861A (zh) * 2016-08-26 2017-02-01 深圳市前海安测信息技术有限公司 生物传感器的微信号多级放大装置及方法
CN206151465U (zh) * 2016-08-26 2017-05-10 深圳市前海安测信息技术有限公司 微信号精密测量电路

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