WO2018030481A1 - Connecteur, récipient de médicament fixé à un connecteur, dispositif d'alimentation en médicament liquide. - Google Patents

Connecteur, récipient de médicament fixé à un connecteur, dispositif d'alimentation en médicament liquide. Download PDF

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Publication number
WO2018030481A1
WO2018030481A1 PCT/JP2017/028978 JP2017028978W WO2018030481A1 WO 2018030481 A1 WO2018030481 A1 WO 2018030481A1 JP 2017028978 W JP2017028978 W JP 2017028978W WO 2018030481 A1 WO2018030481 A1 WO 2018030481A1
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WO
WIPO (PCT)
Prior art keywords
cylinder part
end side
connector
inner cylinder
outer cylinder
Prior art date
Application number
PCT/JP2017/028978
Other languages
English (en)
Japanese (ja)
Inventor
雄史 大黒
Original Assignee
ニプロ株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ニプロ株式会社 filed Critical ニプロ株式会社
Priority to AU2017308385A priority Critical patent/AU2017308385B2/en
Priority to EP17839548.9A priority patent/EP3498251B1/fr
Priority to JP2018533546A priority patent/JP7151481B2/ja
Publication of WO2018030481A1 publication Critical patent/WO2018030481A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2055—Connecting means having gripping means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2068—Venting means
    • A61J1/2075—Venting means for external venting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2079—Filtering means
    • A61J1/2082—Filtering means for gas filtration

Definitions

  • the present invention relates to a connector, a drug container with a connector, and a liquid agent transfer device that are used when preparing a chemical liquid by mixing a drug and a liquid agent.
  • Patent Document 1 JP 2016-511562 A
  • the liquid medicine transfer device disclosed in Patent Document 1 includes a syringe (medicine container), a vial whose mouth is sealed by an elastic lid, a connection device (connector) connected to the tip of the syringe, a connection device and a vial. And a connecting device for connecting the two.
  • the connecting device has a needle portion that has a liquid passage hole and pierces the elastic lid portion.
  • the connecting device includes a cylindrical portion that is screwed with a screwed portion of the syringe and is movable in the axial direction relative to the needle portion.
  • the cylindrical part has a hollow pipe that communicates with the inside of the syringe in a state of being screwed to the syringe on one end side, and a needle part insertion that can receive the proximal end side of the needle part on the other end side Part.
  • the liquid passage hole of the needle part is provided so as to be able to communicate with the hollow pipe line.
  • the syringe After inserting the needle part into the elastic lid part of the vial and attaching the needle part to the vial, the syringe is brought close to one end side of the cylindrical part, and the cylindrical part is screwed into the screwing part of the syringe.
  • the proximal end side of the needle portion is inserted into the needle insertion portion of the syringe screwed into the cylindrical portion, and the syringe is pushed toward the vial. Thereby, the base end side of the needle portion enters the cylindrical portion so as to approach the one end side of the cylindrical portion.
  • the distal end side of the hollow conduit passes through the sealing film provided on the proximal end side of the needle portion, and the inside of the syringe is passed through the hollow conduit of the cylindrical portion and the liquid passage hole of the needle portion. And the inside of the vial communicate.
  • a liquid medicine in a syringe is transferred into a medicine container, and a medicine liquid can be prepared by mixing the liquid medicine and a medicine stored in a vial.
  • the liquid agent transfer device disclosed in Patent Document 1 has a configuration in which the syringe is attached to the connecting device by screwing one end of the cylindrical portion into the screwed portion of the syringe. For this reason, when changing the attitude
  • This invention is made
  • the objective of this invention is providing the connector which can prevent that a chemical
  • the connector based on this invention has an outer cylinder part, the inner cylinder part hold
  • the inner cylinder part is provided on the base end side and includes an insertion part into which the distal end side of the drug container is screwed and inserted, and the ratchet mechanism includes the drug container on the insertion part.
  • the inner cylinder portion In the inserted state, the inner cylinder portion is restricted from rotating in the screwing direction integrally with the drug container, and is moved in a screwing direction opposite to the screwing direction integrally with the drug container.
  • the inner cylinder part is allowed to idle with respect to the outer cylinder part.
  • the ratchet mechanism is fixed relative to the inner cylinder part, and is provided with a ratchet tooth provided so as to protrude radially outward of the inner cylinder part, It is preferable to include a ratchet claw provided on the base end side of the outer cylinder part and protruding from the inner peripheral surface of the outer cylinder part toward the inside of the outer cylinder part.
  • the connector according to the present invention further includes a ratchet tooth support portion that supports the ratchet teeth, and the ratchet tooth support portion includes a flange portion that protrudes radially outward from an outer peripheral surface of the inner cylinder portion, and the inner portion. It is preferable to include a wall portion that extends along the tube axis direction of the tube portion, one end side is connected to the flange portion, and the other end side is a free end, and the ratchet teeth extend from the wall portion to the radial direction. It is preferable to be provided so as to protrude outward.
  • the connector according to the present invention further includes a valve portion that has a valve hole provided to be openable and closable, and closes the distal end side of the outer cylinder portion.
  • a drug container with a connector has an outer cylinder part, an inner cylinder part held in the outer cylinder part in a state of being inserted into the outer cylinder part, and a hollow conduit, and the inner cylinder part And a ratchet that is fixed to the distal end of the inner cylinder and that allows the rotation of the inner cylinder part in the other direction while restricting the rotation of the inner cylinder part in one direction while restricting the rotation of the inner cylinder part in one direction.
  • a connector including a mechanism, a nozzle portion provided on a distal end side, a surrounding portion surrounding at least a proximal end side of the nozzle portion, and a cylindrical container for storing a liquid agent therein, and the cylindrical shape
  • a drug container including a plunger portion inserted from the proximal end side of the container.
  • the inner cylinder portion includes an insertion portion that is provided on a proximal end side and is screwed and inserted at a distal end side of the drug container, and the surrounding portion is screwed to the insertion portion of the connector.
  • the ratchet mechanism is integrated with the drug container and rotates the inner cylinder part in the screwing direction in an insertion state in which the drug container is inserted into the insertion part.
  • the connector is connected to the distal end side of the drug container by the screwed portion being screwed into the insertion portion in a state where the distal end side of the nozzle portion enters the inner cylindrical portion of the connector.
  • the liquid agent transfer device includes an outer cylinder part, an inner cylinder part held in the outer cylinder part in a state of being inserted into the outer cylinder part, and a hollow pipe line.
  • a liquid passage part fixed to the distal end side and accommodated in the outer cylinder part, and a ratchet mechanism that restricts the rotation of the inner cylinder part in one direction and allows the inner cylinder part to rotate in the other direction.
  • a connector having a mouth, the mouth being sealed with an elastic stopper, a vial containing a medicine therein, and a first connecting device for connecting the connector, provided on the distal end side
  • a cylindrical portion that surrounds at least the base end side of the nozzle portion and the nozzle portion, and that contains a liquid agent therein; and a plunger portion that is inserted from the base end side of the cylindrical vessel.
  • the inner cylinder portion includes an insertion portion that is provided on a proximal end side and is screwed and inserted at a distal end side of the drug container, and the surrounding portion is screwed to the insertion portion of the connector.
  • the ratchet mechanism is integrated with the drug container and rotates the inner cylinder part in the screwing direction in an insertion state in which the drug container is inserted into the insertion part. This is regulated, and the inner cylinder part is allowed to idle with respect to the outer cylinder part in a screwing direction opposite to the screwing direction integrally with the drug container.
  • the first connecting instrument is inserted into the distal end side of the outer cylindrical portion of the connector, thereby communicating with the cylindrical portion into which the distal end side of the liquid passage portion is inserted, and the interior of the cylindrical portion. And a puncture needle that has a fluid passage hole and is pierced through the elastic stopper of the vial.
  • the connector is connected to the distal end side of the drug container by screwing the threaded portion into the insertion portion in a state where the distal end side of the nozzle portion enters the inner cylindrical portion of the connector.
  • the puncture needle pierces the elastic stopper of the vial and the distal end side of the liquid passage portion is inserted into the cylindrical portion, the inside of the vial, the liquid passage hole, the inside of the cylindrical portion, The hollow duct of the liquid passage part, the inside of the inner cylinder part, and the inside of the nozzle part communicate with each other, and the liquid agent in the drug container can be transferred into a vial.
  • a connector a drug container with a connector, and a liquid agent transfer device that can prevent the drug container from being detached from the connecting device.
  • FIG. 3 is a cross-sectional view showing each configuration and vial of the liquid medicine transfer device according to the first embodiment.
  • 1 is a perspective view showing a connector according to Embodiment 1.
  • FIG. 3 is a perspective view showing the inside of the base end side of the connector according to Embodiment 1.
  • FIG. 2 is a cross-sectional view of the connector according to Embodiment 1.
  • FIG. It is a perspective view of the 1st connecting instrument illustrated with the one end side of the 1st connecting instrument concerning Embodiment 1 facing up.
  • It is a perspective view of the 1st connecting instrument illustrated with the other end side of the 1st connecting instrument concerning Embodiment 1 facing up.
  • FIG. 3 is a cross-sectional view of the first connecting device according to Embodiment 1.
  • FIG. 1 It is a perspective view which shows the state with which the syringe with a connector which concerns on Embodiment 2, the 2nd coupling device, and the infusion container were connected. It is sectional drawing which shows each structure of the liquid agent transfer apparatus concerning Embodiment 2, and an infusion container. It is a figure which shows an example of the infusion line which concerns on Embodiment 2.
  • FIG. 1 It is a perspective view which shows the state with which the syringe with a connector which concerns on Embodiment 2, the 2nd coupling device, and the infusion container were connected. It is sectional drawing which shows each structure of the liquid agent transfer apparatus concerning Embodiment 2, and an infusion container. It is a figure which shows an example of the infusion line which concerns on Embodiment 2.
  • FIG. 1 is a cross-sectional view showing each configuration and vial of the liquid medicine transfer device according to the first embodiment. With reference to FIG. 1, the liquid agent transfer device according to Embodiment 1 will be described.
  • the liquid medicine transfer device 100 connects the syringe 10 as a drug container, the connector 20 as a connection tool, the first connection tool 30 as a first connection tool, and the vial 40, so that the syringe 10
  • the inside of the vial 40 communicates with the inside of the vial 40 so that the liquid L contained in the syringe 10 can be transferred into the vial 40, and the medicine (not shown) and the liquid L contained in the vial 40 are mixed in the vial 40.
  • a chemical solution is prepared.
  • the liquid agent transfer device 100 includes a syringe 10, a connector 20, and a first connecting device 30.
  • the syringe 10 includes a cylindrical container 11 having both ends opened and a plunger portion 17.
  • the cylindrical container 11 stores the liquid agent L therein.
  • the liquid L is a container that constitutes a medicine.
  • the cylindrical container 11 has a nozzle portion 12 provided on the distal end side and a surrounding portion 13 surrounding the nozzle portion 12.
  • a spiral threaded portion 14 is provided on the inner peripheral surface of the surrounding portion 13.
  • the plunger portion 17 is inserted into the cylindrical container 11 from the proximal end side of the cylindrical container 11.
  • a gasket 16 is provided on the distal end side of the plunger portion 17.
  • the gasket 16 is provided so as to be freely slidable in the cylindrical container 11 and maintains a liquid-tight state between the inner peripheral surface of the cylindrical container 11 and the gasket 16.
  • the liquid agent L is accommodated in a space formed by the cylindrical container 11 and the gasket 16.
  • the gasket 16 natural rubber, butyl rubber, chlorinated butyl rubber, ethylene butadiene rubber, thermoplastic elastomer, and the like can be employed.
  • the vial 40 accommodates a medicine (not shown) inside.
  • the vial 40 includes a container main body 41 having a mouth portion 42 and an elastic stopper 43 that seals the mouth portion 42.
  • a container body 41 a glass container or a resin container can be employed.
  • the elastic plug body 43 for example, a rubber member or a thermoplastic elastomer resin can be employed.
  • FIG. 2 is a perspective view showing the connector according to the first embodiment.
  • 3 is a perspective view showing the inside of the base end side of the connector according to Embodiment 1.
  • FIG. FIG. 4 is a cross-sectional view of the connector according to the first embodiment. With reference to FIG. 2 to FIG. 4, a connector 20 as a connection tool according to Embodiment 1 will be described.
  • the connector 20 includes an outer cylinder part 210, an inner cylinder part 220, a needle part 230, a ratchet mechanism 240, a valve part 250, and a ratchet tooth support part 260.
  • the outer cylinder part 210 includes a first outer cylinder part 211, a second outer cylinder part 212, and a third outer cylinder part 213.
  • the first outer cylinder portion 211 is located on the distal end side of the outer cylinder portion 210.
  • the first outer cylinder part 211 accommodates the distal end side of the inner cylinder part 220 and the distal end side of the needle part 230.
  • the first outer cylinder portion 211 is configured such that one end side of the first connecting device 30, more specifically, a later-described cylindrical portion 310 side (cap portion 350 side) of the first connecting device 30 can be inserted. .
  • a lid 215 is attached to the tip 211a of the first outer cylinder 211.
  • the lid 215 has an annular shape.
  • a through-hole 216 that penetrates in the thickness direction of the lid 215 is formed at the center of the lid 215.
  • the through hole 216 has an outer diameter slightly larger than the outer diameter of the cap portion 350 of the first connecting device 30 described later.
  • a valve portion 250 is sandwiched between the lid portion 215 and the tip 211 a of the first outer cylinder portion 211.
  • the valve part 250 closes the distal end side of the outer cylinder part 210.
  • the valve portion 250 has a valve hole 251 provided so as to open and close in accordance with insertion / extraction of one end side (cap portion 350 side) of the first connecting device 30.
  • the valve hole 251 is provided in a slit shape.
  • the valve part 250 is configured by an elastic member.
  • an elastic member As a material of the elastic member constituting the valve portion 250, any material that can be restored when the load applied to the valve portion 250 is removed can be adopted as appropriate.
  • rubber materials represented by isoprene rubber, butyl rubber, silicone rubber and the like can be employed.
  • the second outer cylinder part 212 is located between the first outer cylinder part 211 and the third outer cylinder part 213, and connects the first outer cylinder part 211 and the third outer cylinder part 213.
  • the inner diameter of the second outer cylinder part 212 is larger than the inner diameter of the first outer cylinder part 211.
  • the second outer cylinder part 212 accommodates a middle part of the inner cylinder part 220 described later (specifically, a base end side of the second inner cylinder part 222), a contact part 223 described later, and an O-ring 270 therein. .
  • the third outer cylinder part 213 is located on the proximal end side of the outer cylinder part 210.
  • the third outer cylinder portion 213 mainly accommodates the proximal end side of the inner cylinder portion 220.
  • the inner diameter of the third outer cylinder portion 213 is larger than the inner diameter of the second outer cylinder portion 212.
  • the third outer cylinder part 213 allows a ratchet tooth 241 described later to rotate around the central axis of the outer cylinder part 210.
  • the inner cylinder part 220 is held by the outer cylinder part 210 in a state of being inserted into the outer cylinder part 210.
  • the cylinder axis of the inner cylinder part 220 coincides with the cylinder axis of the outer cylinder part 210.
  • the inner cylinder part 220 is held by the outer cylinder part 210 so as to be rotatable around the cylinder axis of the inner cylinder part 220.
  • the O-ring 270 when the O-ring 270 is press-fitted between the inner cylinder part 220 and the outer cylinder part 210, the inner cylinder part 220 is rotatably held by the outer cylinder part.
  • the O-ring 270 is located between the flange portion 261 and the abutting portion 223 in the cylinder axis direction. Thereby, the O-ring 270 is prevented from coming off from the inner cylinder part 220.
  • the inner cylinder part 220 has a first inner cylinder part 221 and a second inner cylinder part 222.
  • the first inner cylinder portion 221 has a cylindrical shape.
  • the first inner cylinder part 221 is provided on the proximal end side of the inner cylinder part 220.
  • the first inner cylinder part 221 is mainly located inside the third outer cylinder part 213.
  • a spiral protrusion 225 is provided on the outer peripheral surface of the first inner cylinder 221.
  • a spiral groove 226 is formed between the spiral protrusions 225.
  • the spiral groove 226 is screwed into the screwing portion 14 of the syringe 10.
  • the 1st inner cylinder part 221 functions as an insertion part by which the front end side of the syringe 10 is screwed and inserted.
  • the second inner cylinder portion 222 has a cylindrical shape.
  • the second inner cylinder part 222 is provided on the distal end side of the inner cylinder part 220.
  • the inside of the second inner cylinder part 222 communicates with the inside of the first inner cylinder part 221.
  • the second inner cylinder part 222 is inserted into the second outer cylinder part 212 and the first outer cylinder part 211.
  • a needle base 232 of a needle portion 230 described later is inserted into the second inner cylinder portion 222.
  • Abutting portion 223 is provided on the outer periphery of the second inner cylindrical portion 222.
  • the abutting portion 223 has an annular shape.
  • the abutting portion 223 protrudes radially outward from the outer peripheral surface of the second inner cylinder portion 222.
  • the abutting portion 223 abuts against the proximal end of the first outer cylinder portion 211. Thereby, the inner cylinder part 220 is positioned.
  • the needle part 230 is fixed to the distal end side of the inner cylinder part 220 and is accommodated in the outer cylinder part 210.
  • the needle part 230 includes a needle tube 231 having a hollow duct 231 a and a needle base 232 that holds the needle tube 231.
  • the hollow duct 231a is configured to allow fluid to flow therethrough.
  • the needle part 230 has the hollow pipe 231a so that the liquid agent can flow therethrough and functions as a fluid passage part.
  • the needle base 232 has a bottomed cylindrical shape.
  • the needle base 232 is attached to the second inner cylinder portion 222.
  • the inside of the needle base 232 communicates with the inside of the first inner cylinder portion 221 in a liquid-tight manner.
  • the hollow conduit 231 a of the needle tube 231 communicates with the inside of the first inner cylinder portion 221 in a liquid-tight manner through the inside of the needle base 232.
  • the needle tube 231 is covered with a covering portion 233.
  • the covering portion 233 is constituted by a rubber cap, for example.
  • the covering portion 233 is provided to be elastic.
  • the covering portion 233 is provided so as to be pierced by the needle tube 231.
  • the ratchet mechanism 240 is integrated with the syringe 10 and the inner cylinder part 220 is integrated with the inner cylinder part 220 in the insertion state in which the tip of the syringe is inserted into the first inner cylinder part 221 (insertion part). Is restricted from rotating in the screwing direction (DR1 direction).
  • the ratchet mechanism 240 allows the inner cylinder part 220 to rotate freely with respect to the outer cylinder part 210 in the screwing direction (DR2 direction) integrally with the syringe 10 in the inserted state.
  • the screwing direction is a direction in which the syringe 10 is rotated when the distal end side of the syringe 10 is screwed to the inner cylinder part 220, and the screwing direction is a direction opposite to the screwing direction.
  • the ratchet mechanism 240 has a plurality of ratchet teeth 241 and a plurality of ratchet claws 242.
  • the plurality of ratchet claws 242 have, for example, a plate shape.
  • the plurality of ratchet claws 242 extend along the cylinder axis of the outer cylinder part 210.
  • the plurality of ratchet claws 242 are provided so as to protrude from the inner peripheral surface of the third outer cylinder portion 213 toward the inside of the third outer cylinder portion 213.
  • the plurality of ratchet claws 242 are provided at a 90 ° pitch in the circumferential direction.
  • the plurality of ratchet claws 242 are provided so as to protrude in different directions.
  • the protruding directions of the ratchet claws 242 adjacent to each other counterclockwise differ by 90 ° around the central axis of the outer cylinder part 210.
  • the plurality of ratchet teeth 241 are provided so as to protrude outward in the radial direction of the inner cylindrical portion 220. Specifically, each of the plurality of ratchet teeth 241 is provided so as to protrude from a corresponding wall portion 262 described later toward the radially outer side of the inner cylinder portion 220.
  • the ratchet teeth 241 include an abutting portion 241 a that can abut against the tip 242 a of the ratchet claw 242 and a curved portion 241 b that can slide on the ratchet claw 242.
  • the abutting portion 241a is used when the syringe 10 is further rotated in the screwing direction (DR1 direction) after the tip of the syringe 10 is screwed to the inner cylinder portion 220 (specifically, the first inner cylinder portion 221). It strikes against the tip 242a of the ratchet pawl 242. Thereby, in the said insertion state, it is controlled that the inner cylinder part 220 rotates in the screwing direction (DR1 direction) integrally with the syringe 10.
  • the curved portion 241b is formed in a substantially fan shape, and is configured to be slidable on the ratchet claw 242 located on the front side in the rotational direction in the screwing direction (DR2 direction).
  • the holding force with which the outer cylinder part 210 holds the inner cylinder part 220 is that the syringe 10 and the inner cylinder are necessary when the syringe 10 is screwed out from the insertion state where the tip of the syringe 10 is attached to the first inner cylinder part 221. It is smaller than the frictional force with the part 220.
  • Each of the plurality of ratchet teeth 241 is fixed relative to the inner cylinder portion 220.
  • the plurality of ratchet teeth 241 are supported by the ratchet tooth support 260.
  • the ratchet tooth support 260 includes a flange portion 261 and a plurality of wall portions 262.
  • the flange part 261 protrudes from the outer peripheral surface of the first inner cylinder part 221 to the outside in the radial direction of the first inner cylinder part 221.
  • the flange portion 261 has a substantially annular shape.
  • the plurality of wall parts 262 extend along the cylinder axis of the inner cylinder part 220. One end side of each of the plurality of wall portions 262 is connected to the peripheral edge portion of the flange portion 261. The other end side of each of the plurality of wall portions 262 is a free end. Thereby, the plurality of wall portions 262 can be flexibly deformed. When the syringe 10 is rotated in the screwing direction in the inserted state of the syringe 10, the wall portion 262 is bent and deformed to reduce the sliding resistance between the ratchet teeth 241 and the ratchet claw 242, and The cylindrical portion 220 can be easily rotated.
  • the plurality of wall portions 262 are arranged at intervals in the circumferential direction.
  • the plurality of wall portions 262 are provided according to the number of the plurality of ratchet teeth 241.
  • FIG. 5 is a perspective view of the first connecting device illustrated with the one end side of the first connecting device according to Embodiment 1 facing upward.
  • FIG. 6 is a perspective view of the first connecting device illustrated with the other end side of the first connecting device according to Embodiment 1 facing upward.
  • FIG. 7 is a cross-sectional view of the first connecting device according to the first embodiment. With reference to FIGS. 5 to 7, the first connecting device 30 according to the first embodiment will be described.
  • the first connecting device 30 includes a cylindrical part 310, a puncture needle 320, a vial insertion part 330, a port 340, and a cap part 350.
  • the cylindrical portion 310 is provided on one end side (base end side) of the first connecting device 30.
  • the cylindrical portion 310 is configured to receive the distal end side of the needle portion 230 (specifically, the distal end side of the needle tube 231).
  • the cylindrical part 310 is covered with a cap part 350.
  • the cap part 350 includes a cylindrical main body part 351 and a sealing film 352.
  • the main body 351 covers the periphery of the cylindrical portion 310.
  • the sealing film 352 closes one end side of the main body portion 351 and closes one end side of the cylindrical portion 310.
  • the sealing film 352 has a first film body 353 and a second film body 354.
  • the sealing film 352 is formed by overlapping the first film body 353 and the second film body 354 in the cylinder axis direction of the cap portion 350.
  • the surface of the first film body 353 on the second film body 354 side and the surface of the second film body 354 on the first film body 353 side are in close contact with each other.
  • the sealing film 352 is formed as an integral elastic body in which the first film body 353 and the second film body 354 are stacked and in close contact with each other.
  • the puncture needle 320 is provided on the other end side (front end side) of the first connecting device 30.
  • the puncture needle 320 is provided so that the elastic stopper 43 of the vial 40 can be pierced.
  • the puncture needle 320 is linearly arranged with respect to the cylindrical part 310 along the axial direction of the cylindrical part 310.
  • the puncture needle 320 has a first hole portion 321 and a second hole portion 322 as liquid passage holes.
  • One end side of the first hole portion 321 is connected to the other end side of the cylindrical portion 310.
  • the first hole portion 321 communicates with the inside of the tubular portion 310.
  • the other end side of the first hole portion 321 opens to the outer peripheral surface of the puncture needle 320.
  • the first hole 321 is preferably formed at a position shifted from the axis of the puncture needle 320.
  • the second hole 322 is independent of the first hole 321.
  • One end side of the second hole 322 is connected to the port 340.
  • the other end side of the second hole portion 322 opens to the other end side of the puncture needle 320.
  • the port 340 is for releasing the gas in the vial 40 out of the system when the internal pressure of the vial 40 rises.
  • An aerosol filter 341 is disposed in the port 340. The aerosol filter 341 prevents the aerosol containing components such as the liquid L, the drug, and the chemical liquid from leaking out of the system.
  • the forming material of the aerosol filter 341 is a hydrophobic material such as a water repellent resin such as polytetrafluoroethylene or ethylene-tetrafluoroethylene, or a resin or fiber whose surface is water repellent.
  • a hydrophobic material such as a water repellent resin such as polytetrafluoroethylene or ethylene-tetrafluoroethylene, or a resin or fiber whose surface is water repellent.
  • the pore size, structure, and thickness of the aerosol filter 341 are appropriately selected. Aerosols that float for a long time generally have a diameter of about 10 nm to 500 nm. Considering the electrostatic characteristics of the aerosol, a hydrophilic filter, a positive or negative charge filter, activated carbon, etc. can be combined. In combination, the aerosol filter 341 may be formed.
  • the first connecting device 30 may be configured not to include the aerosol filter 341.
  • the vial insertion part 330 has a cylindrical shape.
  • the vial insertion part 330 is provided in the mouth part 42 of the vial 40 so that attachment is possible.
  • the inner diameter of the vial inserting portion 330 is slightly smaller than the mouth portion 42. In a state where the vial inserting portion 330 is attached to the mouth portion 42, the vial inserting portion 330 is spread outward, and the inner peripheral surface of the vial inserting portion 330 sandwiches the outer peripheral portion of the mouth portion 42.
  • the vial insertion part 330 is provided with a notch 331. By providing the notch portion 331, the vial insertion portion 330 is easily bent and deformed, and the insertion into the mouth portion 42 is facilitated.
  • the inner peripheral surface of the vial inserting portion 330 is slidably provided on the outer periphery of the mouth portion 42. In a state where the vial insertion portion 330 is inserted into the mouth portion 42, the first connecting device 30 can be pushed into the vial 40 side.
  • the vial insertion part 330, and the puncture needle 320 and the cylindrical part 310 described above may be integrally formed.
  • a material constituting the vial insertion part 330, the puncture needle 320, and the cylindrical part 310 ABS resin, SB resin, polycarbonate, and polystyrene are preferably used.
  • the first connecting device 30 may further include a protective cap 360.
  • the protective cap 360 protects the puncture needle 320.
  • the protective cap 360 is removed from the puncture needle 320 when the first connecting device 30 is attached to the vial 40.
  • FIG. 8 is a cross-sectional view showing a state where the syringe according to Embodiment 1 is inserted into the connector. As shown in FIG. 8, when the syringe 10 is attached to the connector 20, the distal end side of the syringe 10 is inserted into the first inner cylinder portion 221 from the proximal end side of the connector 20 with the distal end of the syringe 10 facing upward. To do.
  • the syringe 10 is mounted on the connector by rotating the syringe 10 in the screwing direction and screwing the syringe 10 into the screwed portion 14 of the syringe 10 in the spiral groove 226 formed on the outer peripheral side of the first inner cylinder portion 221. To do. Thereby, the syringe with a connector as a chemical
  • the syringe 10 In the insertion state in which the syringe 10 is attached to the connector, the syringe 10 can rotate integrally with the inner cylinder portion 220 in the screwing direction (DR1) and the screwing direction (DR2 direction) as described above. Yes.
  • FIG. 9 is a bottom view showing the first state of the connector in the inserted state shown in FIG.
  • FIG. 9 only the connector 20 is shown from the base end side, and the syringe 10 is omitted.
  • FIG. 10 is a bottom view showing the second state of the connector in the inserted state shown in FIG.
  • FIG. 10 only the connector 20 is shown from the base end side, and the syringe 10 is omitted.
  • the holding force with which the outer tube portion 210 holds the inner tube portion 220 is smaller than the friction force between the syringe 10 and the inner tube portion 220 that is required when the syringe 10 is screwed out from the inserted state.
  • the syringe 10 is rotated in the screwing direction (DR2), the syringe 10 is integrated with the inner cylinder part 220 in the screwing direction without being screwed off from the inner cylinder part 220. Rotate.
  • the syringe 10 and the inner cylinder portion 220 are integrated and idle with respect to the outer cylinder portion 210, whereby the syringe 10 can be prevented from being detached from the connector 20. As a result, the liquid L can be prevented from leaking out of the syringe 10.
  • FIG. 11 is a cross-sectional view showing a state where the first coupling device according to Embodiment 1 is connected to a vial.
  • the vial insertion part 330 is attached to the mouth part 42 by pushing down the first connecting device 30 toward the vial 40 side while puncturing the elastic stopper body 43 of the vial 40 with the puncture needle 320.
  • the first connecting device 30 is connected to the vial 40.
  • the present invention is not limited to this, and the first connecting device 30 is not limited thereto.
  • the syringe 10 may be attached to the connector 20.
  • FIG. 12 is a cross-sectional view showing a state where the syringe with connector, the first connecting device, and the vial according to the first embodiment are connected.
  • the syringe with connector when connecting the syringe with connector, the first connecting device 30, and the vial 40, the syringe with connector is inserted into the first connecting device 30 connected to the vial 40, and the first connecting device 30.
  • the vial 40 and the connector 20 are connected to each other through the connector.
  • the syringe with connector is inserted into the outer cylinder part 210 so that one end side (cap part 350 side) of the first connection instrument 30 passes through the valve hole 251 and the first connection instrument 30. Push down to the side.
  • the covering portion 233 that covers the needle tube 231 contacts the sealing film 352 that seals the inside of the cap portion 350 and seals the opening on one end side of the cylindrical portion 310.
  • the covering portion 233 is elastically deformed, and the needle tube 231 penetrates the covering portion 233 and pierces the first film body 353 and the second film body 354.
  • the distal end side of the needle portion 230 (specifically, the distal end side of the needle tube 231) is inserted into the cylindrical portion 310.
  • the first film body 353 and the second film body 354 are in close contact with the periphery of the needle tube 231, so that the hollow conduit 231 a communicates with the inside of the cylindrical portion 310 while maintaining a liquid-tight state. .
  • the connector 20 is inserted into the distal end side of the syringe 10 when the screwing portion 14 is screwed into the spiral groove 226 in a state where the distal end side of the nozzle portion 12 enters the inner cylindrical portion 220 of the connector 20.
  • the puncture needle 320 is inserted through the elastic stopper 43 of the vial 40 and the distal end side of the needle portion 230 is inserted into the cylindrical portion 310, the inside of the vial 40, the first hole portion 321,
  • the inside of the cylindrical portion 310, the hollow pipe 231a of the needle portion 230, the inside of the inner cylindrical portion 220, and the inside of the nozzle portion 12 communicate with each other. Accordingly, the liquid L in the syringe 10 can be transferred into the vial 40.
  • the liquid L inside the syringe 10 becomes the inside of the nozzle portion 12, the inside of the inner cylinder portion 220, the inside of the hollow duct 231 a, the inside of the cylindrical portion 310, the first It is transferred into the vial 40 so as to be jetted onto the inner wall of the vial 40 via the hole 321.
  • the gas in the vial 40 is discharged out of the system from the port 340 via the second hole 322 formed in the puncture needle 320.
  • the aerosol filter 341 prevents the aerosol generated by the injection of the liquid L from being discharged out of the system.
  • the desired drug solution can be prepared by dissolving the drug in the vial 40 in the transferred solution L.
  • the liquid medicine transfer device 100 and the vial 40 are kept upside down while being maintained in a connected state. That is, the attitude
  • the connector-attached syringe is removed from the first connecting device 30 in order to put the drug solution sucked into the syringe 10 again into the liquid agent accommodated in the infusion container 50 (see FIG. 13).
  • the connector-attached syringe is connected to the first connecting device 30 so that one end side (cap portion 350 side) of the first connecting device 30 passes through the valve hole 251 and is extracted to the outside of the outer tube portion 210. Pull away from.
  • the needle tube 231 is withdrawn from the first film body 353 and the second film body 354.
  • the chemical solution attached when the adjusted chemical solution is transferred from the vial 40 to the syringe 10 remains.
  • the needle tube 231 When the needle tube 231 is withdrawn from the first film body 353 and the second film body 354, the needle tube 231 is in a state where the first film body 353 and the second film body 354 are in close contact with the outer peripheral surface of the needle tube 231. Slides relative to the first film body 353 and the second film body 354. As a result, the first film body 353 and the second film body 354 cause the needle tube 231 to act. As a result, the chemical solution attached to the outer surface of the needle tube 231 is removed. The chemical solution scraped by the first film body 353 and the second film body 354 is captured between the first film body 353 and the second film body 354.
  • the covering portion 233 returns to its original shape, covers the needle tube 231, and one end side of the first connecting device 30 is taken out from the outer tube portion 210. Therefore, the valve hole 251 of the valve part 250 is closed.
  • a syringe 10 and the infusion container in which the liquid agent was accommodated are connected separately using a 1st connection instrument, and a chemical
  • the ratchet mechanism 240 is 10
  • the inner cylinder portion 220 is restricted from rotating in the screwing direction
  • the inner cylinder portion 220 is integrated with the syringe 10 in the screwing direction opposite to the screwing direction with respect to the outer cylinder portion 210. Allow idling.
  • the syringe 10 cannot be removed from the connector 20. For this reason, it is possible to prevent the connector 20 from being unintentionally detached from the syringe 10 and the liquid agent from leaking out of the syringe 10.
  • the needle tube 231 of the connector 20 is covered with the covering portion 233 in a state before the syringe 10 and the connector 20 are connected. Also, the liquid agent in the syringe 10 can be prevented from leaking out. Furthermore, by providing the valve portion 250 that closes the distal end side of the outer cylinder portion 210 of the connector 20, it is possible to further prevent the liquid agent from leaking from the connector 20.
  • the covering portion 233 returns to its original state, and the needle tube 231 of the connector 20 is covered by the covering portion 233. It is possible to prevent the liquid agent from leaking into the syringe 10 from the 20 side.
  • FIG. 13 is a perspective view showing a state in which the syringe with connector, the second connector, and the infusion container according to Embodiment 2 are connected.
  • FIG. 14 is a cross-sectional view showing each configuration of the liquid agent transfer device and the infusion container according to the second embodiment. With reference to FIG. 13 and FIG. 14, each structure of the liquid agent transfer device 100A according to the second embodiment and the infusion container 50 will be described.
  • the infusion container 50 contains a liquid agent inside.
  • the infusion container 50 includes a container main body 51 having a mouth portion 52 and an elastic plug 53 that seals the mouth portion 52.
  • the mouth portion 52 includes a first frame body 521 that penetrates the container main body 51 and a second frame body 522 that is attached to the tip of the first frame body 521.
  • the first frame body 521 and the second frame body 522 have a cylindrical shape.
  • the first frame body 521 and the second frame body 522 are made of, for example, a resin member.
  • the elastic plug 53 is held by the second frame 522.
  • a rubber member or a thermoplastic elastomer resin can be employed.
  • liquid transfer device 100A 100 A of liquid agent transfer apparatuses are for using the chemical
  • 100 A of liquid agent transfer apparatuses are provided with the connector 20, the syringe 10, and the 2nd connection tool 30A as a 1st connection tool.
  • the second connecting device 30A has an outlet port 380 formed on one end side and a puncture needle 320A formed on the other end side, with the direction of piercing the stopper of the infusion container 50 as an axis, and is tubular in an oblique direction from the axis.
  • the portion 310 is provided so as to protrude.
  • the configurations of the cylindrical portion 310 and the cap portion 350 of the second connecting device 30A are substantially the same as the configurations of the cylindrical portion 310 and the cap portion 350 of the first connecting device 30.
  • the configuration of the puncture needle 320A is substantially the same as the configuration of the puncture needle 320 of the first connecting device 30.
  • the puncture needle 320A has a first hole 321A and a second hole 322A as liquid passage holes.
  • the first hole portion 321 ⁇ / b> A communicates with the inside of the tubular portion 310.
  • the second hole 322A is independent of the first hole 321A.
  • the second hole 322A is connected to the outlet port 380.
  • a closing member 381 that is pierced by a bottle needle of an infusion line is provided at the tip of the outlet port 35.
  • the closing member 381 is usually an elastic thin film that can be pierced by the bottle needle of the infusion line and that the bottle needle does not easily come off or impair liquid tightness after piercing.
  • a material for forming the closing member 381 satisfying such performance natural rubber, butyl rubber, chlorinated butyl rubber, styrene butadiene rubber, thermoplastic elastomer, and the like are appropriately selected in consideration of compatibility with the wetted chemical.
  • the opening of the outlet port 380 is preferably a cylindrical shape having an inner diameter slightly smaller than the bottle needle in order to help hold the bottle needle of the infusion line.
  • a fluid passing valve (not shown) that allows fluid to flow at a predetermined pressure or more in both directions is provided.
  • the liquid passing valve is configured to allow communication between the first hole 321A and the inside of the cylindrical portion 310.
  • the liquid passing valve is opened when a predetermined pressure or more is applied when the chemical liquid is transferred from the syringe 10 to the infusion container 50.
  • the liquid passing valve allows the liquid to flow from the inside of the cylindrical portion 310 toward the first hole portion 321A and prohibits the flow in the opposite direction, and irreversibly passes the chemical liquid from the syringe 10 to the infusion container 50. It may be a one-way valve that can be transferred.
  • a syringe with a connector that accommodates the drug solution adjusted as described above is inserted into the second connecting device 30A, and the infusion container 50 and the connector 20 are connected through the second connecting device 30A.
  • the inside of the infusion container 50, the first hole portion 321A, the inside of the cylindrical portion 310, the hollow conduit 231a of the needle portion 230, the inside of the inner cylindrical portion 220, and the inside of the nozzle portion 12 communicate with each other.
  • the chemical solution in the syringe 10 can be transferred into the infusion container 50.
  • the chemical solution inside the syringe 10 is transferred to the inside of the nozzle portion 12, the inside of the inner cylinder portion 220, the inside of the hollow pipe 231 a, the inside of the cylindrical portion 310, and the first hole. It is transferred into the infusion container 50 via the part 321. Thereby, a new chemical
  • FIG. 15 is a diagram illustrating an example of an infusion line according to the second embodiment.
  • the infusion container 50, the other infusion container 50A, the bottle needles 71 and 71A, the drip cylinders 72 and 72A, the roller clamps 73 and 73A, the tubes 74 and 74A, and the connector 75. , 75A constitute the infusion line 400 and administer the adjusted medicinal solution to the patient.
  • the ratchet mechanism 240 is configured by the ratchet teeth 241 and the ratchet claws 242 is described as an example.
  • the present invention is not limited to this, and the ratchet claws 242 are not limited thereto. It may replace with and may be comprised by the ratchet groove
  • the present invention is not limited thereto, and unless the insertion of the tip of the syringe 10 is affected, You may provide directly in the inner cylinder part 220.
  • the ratchet tooth support portion 260 is configured by the inner cylinder portion 220.
  • Embodiment 1 the case where a syringe and a vial are connected is illustrated as a usage mode of a liquid agent transfer device, and in Embodiment 2, a syringe and an infusion container are used as usage modes of a liquid agent transfer device.
  • the liquid agent transfer apparatus of this invention is not limited to such an example.
  • the liquid agent transfer device of the present invention can be used when transferring an arbitrary liquid that is not desired to be leaked to the outside.
  • the liquid agent transfer device of the present invention can be used when transferring a liquid containing dangerous drugs such as anticancer agents, pathogenic bacteria, and bacteria that are difficult to be resistant.
  • a liquid containing dangerous drugs such as anticancer agents, pathogenic bacteria, and bacteria that are difficult to be resistant.
  • the liquid agent transfer device of the present invention can be suitably used.
  • the liquid agent transfer device of the present invention can also be used when transferring a solution containing a dangerous solvent such as trichlorethylene or an environmental hormone.

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

Ce connecteur (20) comporte : une partie de tube externe (210); une partie de tube interne (220) maintenue dans la partie de tube externe (210); une partie de trajet d'écoulement de liquide ayant un trajet de tube creux à l'intérieur de la partie de tube externe (210); et un mécanisme à cliquet (240) qui restreint la rotation de la partie de tube interne (220) dans une direction et qui permet la rotation de la partie de tube interne (220) dans l'autre direction. La partie de tube interne (220) comprend une partie d'insertion qui est disposée sur le côté d'extrémité de base et dans laquelle le côté de pointe d'un récipient de médicament est inséré par vissage. Tandis que le récipient de médicament est inséré dans la partie d'insertion, le mécanisme à cliquet (240) empêche le tube interne (220) de tourner dans le sens de vissage en étant intégré au récipient de médicament, et permet au tube interne (220) de tourner librement, par rapport à la partie de tube externe (210), en étant intégré au récipient de médicament dans la direction de dévissage, qui est la direction opposée à la direction de vissage.
PCT/JP2017/028978 2016-08-09 2017-08-09 Connecteur, récipient de médicament fixé à un connecteur, dispositif d'alimentation en médicament liquide. WO2018030481A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2017308385A AU2017308385B2 (en) 2016-08-09 2017-08-09 Connector, Connector-Attached Drug Container, and Liquid Drug Transfer Device
EP17839548.9A EP3498251B1 (fr) 2016-08-09 2017-08-09 Connecteur, récipient de médicament fixé à un connecteur, dispositif d'alimentation en médicament liquide
JP2018533546A JP7151481B2 (ja) 2016-08-09 2017-08-09 コネクタ、コネクタ付薬剤容器、液剤移送装置

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2016-156513 2016-08-09
JP2016156513 2016-08-09

Publications (1)

Publication Number Publication Date
WO2018030481A1 true WO2018030481A1 (fr) 2018-02-15

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PCT/JP2017/028978 WO2018030481A1 (fr) 2016-08-09 2017-08-09 Connecteur, récipient de médicament fixé à un connecteur, dispositif d'alimentation en médicament liquide.

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EP (1) EP3498251B1 (fr)
JP (1) JP7151481B2 (fr)
AU (1) AU2017308385B2 (fr)
WO (1) WO2018030481A1 (fr)

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US20210038475A1 (en) * 2018-02-27 2021-02-11 Equashield Medical Ltd. Apparatus for securing device couplings
JP2022031443A (ja) * 2019-04-30 2022-02-18 ウェスト ファーマ サービシーズ イスラエル リミテッド デュアルルーメンｉｖスパイク付き液体移送装置

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WO2011150037A1 (fr) * 2010-05-27 2011-12-01 J&J Solutions, Inc. Système fermé de transfert de fluide
US20140311624A1 (en) * 2011-10-14 2014-10-23 Novo Nordisk Healthcare Ag Pre-Assembled Fluid Transfer Arrangement
JP2016511662A (ja) 2013-02-07 2016-04-21 エクアシールド メディカル リミテッド 薬剤移送密閉システムへの改良
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Cited By (4)

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Publication number Priority date Publication date Assignee Title
US20210038475A1 (en) * 2018-02-27 2021-02-11 Equashield Medical Ltd. Apparatus for securing device couplings
CN108168986A (zh) * 2018-03-21 2018-06-15 深圳市鹏医疗仪器有限公司 全自动液基细胞制片染色一体机及制片染色方法
JP2022031443A (ja) * 2019-04-30 2022-02-18 ウェスト ファーマ サービシーズ イスラエル リミテッド デュアルルーメンｉｖスパイク付き液体移送装置
US11786442B2 (en) 2019-04-30 2023-10-17 West Pharma. Services IL, Ltd. Liquid transfer device with dual lumen IV spike

Also Published As

Publication number Publication date
AU2017308385B2 (en) 2021-12-02
JPWO2018030481A1 (ja) 2019-06-13
JP7151481B2 (ja) 2022-10-12
AU2017308385A1 (en) 2019-03-21
EP3498251A1 (fr) 2019-06-19
EP3498251A4 (fr) 2020-03-04
EP3498251B1 (fr) 2021-04-07

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