WO2018021816A1 - Dispositif de préparation d'injection anticancéreuse et système de préparation d'injection anticancéreuse le comprenant - Google Patents

Dispositif de préparation d'injection anticancéreuse et système de préparation d'injection anticancéreuse le comprenant Download PDF

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Publication number
WO2018021816A1
WO2018021816A1 PCT/KR2017/008039 KR2017008039W WO2018021816A1 WO 2018021816 A1 WO2018021816 A1 WO 2018021816A1 KR 2017008039 W KR2017008039 W KR 2017008039W WO 2018021816 A1 WO2018021816 A1 WO 2018021816A1
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WIPO (PCT)
Prior art keywords
anticancer
injection
anticancer agent
supply unit
unit
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PCT/KR2017/008039
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English (en)
Korean (ko)
Inventor
박석훈
이찬호
홍일화
Original Assignee
큐렉소 주식회사
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Publication of WO2018021816A1 publication Critical patent/WO2018021816A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms

Definitions

  • the present invention relates to an anticancer injection preparation device and an anticancer injection preparation system including the same, and more particularly, an anticancer injection that can prepare an anticancer injection by minimizing waste of drugs through an automated facility and extracting quantitative anticancer drugs and sap.
  • the present invention relates to a preparation device and an anticancer injection preparation system including the same.
  • anticancer injections are used in a form in which intravenous injection is possible by mixing an anticancer agent with a certain amount of fluid.
  • the pharmacist extracts and mixes the anticancer agent and the sap manually, and thus it is difficult to quantitatively and accurately determine whether or not the correct preparation is made. Therefore, an incorrect amount is prepared according to the manual operation, thereby increasing the risk of patients using anticancer injections. .
  • the pharmacist extracts and mixes the anticancer agent and the sap manually according to the judgment of the pharmacist, thereby increasing the amount of work of the pharmacist and difficulty in preparing a quantitative anticancer injection.
  • the present invention has been made to solve the above problems of the prior art, by reducing the intervention of the pharmacist through an automated facility to extract the quantitative anticancer and sap and to check the mixed amount of the mixed anticancer injection, reducing the manpower and pharmacist It is an object of the present invention to provide an anticancer injection preparation device and an anticancer injection preparation system including the same, which can ensure the safety of the drug and prepare a quantitative anticancer injection.
  • a sterile preparation stage is provided in the sterile chamber is provided with a preparation chamber for preparing an anticancer injection;
  • a drug supply unit installed in the sterile preparation station and fixed with a plurality of anticancer agent vials containing an anticancer agent, and selecting any one of a plurality of anticancer agent vials to supply an anticancer agent;
  • An injection device operable to be aligned with a location of an anticancer agent vial installed in the drug supply unit, and extracting an anticancer agent from the anticancer agent vial installed in the drug supply unit and injecting the anticancer agent extracted into the place where the sap is accommodated;
  • Sap supply unit is installed in the aseptic preparation, for supplying the sap mixed with the anticancer agent;
  • a mixing unit provided with a mixing container for mixing the anticancer agent supplied from the injection device with the sap supplied from the infusion supply unit.
  • the drug supply unit and the injection device is coupled, the lifting unit for lifting the medicine supply unit and the injection device; And a support part installed on the sterile preparation base and supporting the lifting part, wherein the lifting part is coupled to the support part to be inserted into the support part.
  • the drug supply unit the first fixing member is installed on the sterile preparation table, the anticancer drug vial is arranged in alignment with the injection device while rotating about any one axis of the vertical;
  • a second fixing member installed on the sterile preparation table and installed to allow the anticancer drug vial to be arranged in an arc shape so that the anticancer vial can be aligned with the injection device while rotating about the axis of rotation of the injection device. It is characterized by including.
  • the injection device a syringe for extracting an anticancer agent from the drug supply;
  • a rotating part installed below the syringe and allowing the syringe to rotate toward a position of an anticancer drug vial installed in the medicine supplying part;
  • a first linear installed at an upper portion of the rotating part to allow the syringe to linearly move toward the position of the anticancer drug vial;
  • a second linear installed above the first linear to operate the piston of the syringe to extract or inject the anticancer agent.
  • the sap supply unit the sap bag installation unit is installed sap bag;
  • a first connection tube connected to one side of the sap bag and transferring the sap extracted from the sap bag;
  • a metering pump connected to one side of the first connecting tube and pumping and discharging the pump to be extracted from the sap bag by a predetermined amount through the first connecting tube;
  • a second connecting tube for transferring the sap discharged from the metering pump to the mixing unit.
  • an anticancer bag in which a large amount of anticancer agent is stored is installed in the sap bag installation unit, and a first connection tube is installed to be connected to one side of the anticancer agent bag, thereby allowing a large amount by operation of a metering pump It is characterized in that the anticancer agent can be injected into the mixing vessel through the second connecting tube.
  • the first electronic balance is further installed in the mixing part to check the weight of the anticancer agent and the sap contained in the mixing container.
  • a shaker is further installed in order to inject the sap into the anticancer agent and to mix the anticancer agent in the sap.
  • the method may further include an information input unit for inputting prescription information describing the anticancer injection component, inputting information about the prepared anticancer injection component, and storing the data as data.
  • the information input unit a bar code output unit for outputting the information on the prescription information and the components of the prepared anticancer injection drug delivered through the interlocking hospital network;
  • a barcode reader for reading prescription information and ingredient information of the prepared anticancer injection;
  • a touch screen for displaying and storing the information input through the barcode reader and transmitting the information to the place where the anticancer injection is prepared and the hospital computer network.
  • a plurality of anticancer drug vials containing an anticancer agent are fixed, and any one of a plurality of anticancer drug vials is selected to supply an anticancer drug, and a mixed container for supplying a anticancer agent and an aqueous solution to mix the sap.
  • An anticancer injection preparation device for preparing an anticancer injection using a medicine supply unit and a mixing container supplied from the supply unit;
  • a transport robot for transporting the drug supply unit and the mixed container supplied from the supply unit to the anticancer injection preparation device or for transporting the mixed container containing the drug supply unit and the anticancer injection drug from the anticancer injection device;
  • an ejecting unit for carrying out the medicine supplying unit which is transported from the anticancer injection preparation device and the mixed container containing the anticancer injection by the transfer robot.
  • the anticancer injection preparation system comprises a plurality of the anticancer injection preparation device, the anticancer injection preparation device is characterized in that each installed so that the separation distance from the transport robot is located at the same position.
  • the anticancer injection preparation device and the anticancer injection preparation system including the same according to the present invention have the following effects.
  • the quantitative anticancer agent is extracted from the anticancer agent vial installed in the drug supply unit and injected into the mixing container installed in the mixing unit, and the quantitative sap is extracted from the sap bag installed in the sap supply unit by the metering pump and injected into the mixing container of the mixing unit.
  • anticancer injectable drugs in which a fixed amount of anticancer agent and sap are mixed can be prepared.
  • the anticancer agent is injected into the mixing portion of the mixing unit by using a metering pump, and when a powdered anticancer agent is used, the sap is injected and the anticancer agent is dissolved in the sap through the shaker and mixed.
  • FIG 1 is an overall configuration diagram schematically showing the configuration of an anticancer injection preparation device according to the present invention.
  • Figure 2 is a view showing the main configuration of the anticancer injection preparation device according to the present invention.
  • Figure 3 is a view showing the main components of the anticancer injection preparation device according to another embodiment of the present invention.
  • Figure 4 is a view of the anticancer injection preparation device of the present invention showing a state in which a large amount of anticancer agents are used.
  • Figure 5 is a view showing the main components of the anticancer injection preparation device according to another embodiment of the present invention.
  • 6 and 7 is an operating state diagram showing a schematic operation of the anticancer injection preparation device according to another embodiment of the present invention.
  • FIG. 8 is a schematic operation state diagram showing an anticancer injection preparation system according to the present invention.
  • FIG. 1 is an overall configuration diagram schematically showing the configuration of an anticancer injection preparation device according to the present invention
  • Figure 2 is a view showing the main configuration of the anticancer injection preparation device according to the present invention
  • Figure 3 is an anticancer according to another embodiment of the present invention
  • Fig. 4 shows the main structure of an injection preparation device.
  • Fig. 4 is a view of the anticancer injection preparation device of the present invention showing a state in which a large amount of anticancer drugs are used.
  • the anticancer injection preparation device 1 is largely, a sterile preparation table 10, the drug supply unit 20, the injection device 30, the fluid supply unit 40, It is comprised including the mixing part 50.
  • the present invention relates to an anticancer injection preparation device capable of preparing an accurate anticancer injection.
  • the sterile preparation table 10 provides a space for preparing an anticancer injection.
  • the sterile dispensing table 10 is a support 110 is installed on the ground so that a certain height can be floated from the ground to facilitate the pharmacist or manager, the preparation unit and the preparation work on the support 110 Preparation room 120 is provided with a space for performing this.
  • the sterile preparation table 10 is basically installed in a sterile chamber, and one or two pharmacists per dispensing room 120 may be arranged to perform anticancer injection preparation.
  • the dispensing room 120 is formed in the form of a part when viewed from the front, and may be provided with an extended space therein, the table 121 for placing equipment and drugs is provided, This allows the pharmacist to handle the equipment or drug and perform the preparation.
  • the support 110 may be further provided with a moving means (for example, wheels) and the like in contact with the ground to improve mobility.
  • a moving means for example, wheels
  • the non-defective supply unit 20 is a part for supplying the anticancer agent.
  • the drug supply unit 20 is installed in the preparation chamber 120 of the sterile preparation table 10.
  • the drug supply unit 20 may be attached to a structure such as a separate block is installed, the shape of the block is not limited.
  • the drug supply unit 20 is a part for supplying the anticancer drug and the sap in the preparation of anticancer injections, a plurality of anticancer vials (vial) (3) is installed to continuously supply a large amount of anticancer drugs It is a part.
  • the anticancer drug vial 3 is stored as a pure anticancer drug without the addition of sap, and the inlet is formed to insert the injection needle in the form of a glass bottle.
  • the drug supply unit 20 is configured such that a plurality of anticancer drug vials 3 are installed to continuously perform the anticancer drug extraction.
  • any one of the plurality of anticancer agent vials 3 may be selected to be formed to supply the anticancer agent.
  • the drug supply unit 20 may supply an anticancer agent stored in a container of another type in addition to the anticancer agent vial 3 in some cases.
  • the drug supply unit 20 is configured to include a first fixing member 210 and the second fixing member 220 according to its form.
  • the first fixing member 210 is disposed above the table 121 of the preparation chamber 120 and a rotation shaft 211 is installed to rotate about any axis vertically when viewed from the front, and the The rotating shaft 211 is provided with a jig plate 212 in which the anticancer agent vial 3 is installed.
  • a first clamp 212a is installed at the edge of the jig plate 212 so that a plurality of anticancer vials 3 are disposed and fixed.
  • the rotary shaft 211 is formed so as to be rotated in the vertical phase
  • the jig plate 212 in the form of a circular or square plate is installed on the rotary shaft 211
  • the anticancer agent vial 3 is installed in the clamp 212a so that the anticancer agent vial 3 can be arranged in a specific position as the jig plate 212 is rotated.
  • the position at which the anticancer agent vial 3 is aligned refers to a position coinciding with the position of the injection device 30 described later.
  • the second fixing member 220 is disposed above the table 121 of the preparation chamber 120 such that a plurality of anticancer vials 3 are arranged in an arc shape when viewed from the front. It is formed to be.
  • the second fixing member 220 includes a power unit 221, an arc member 222, and a second clamp 222a.
  • the power unit 221 is installed below the arc member 222, that is, to be disposed inside the arc member 222 when viewed from the front to move the arc member 222 to the left or right.
  • the arc member 222 is formed in the shape of an arc strip (arc) is moved to the left or right on the power unit 221 by the power unit 221, the arc member 222 at a predetermined interval of the anticancer agent A plurality of second clamps 222a are installed to fix the vials 3.
  • the arc member 222 moves to rotate left or right, and the anticancer agent vial 3 fixed to the second clamp 222a is erected vertically in an inclined state. It can be placed in a state.
  • the reference position of the second fixing member 220 may be the same position as the injection device 30.
  • the injection device 30 serves to extract the anticancer agent from the anticancer agent vial 30 or inject into the place where the fluid is accommodated.
  • the injection device 30 is installed above the table 121 of the preparation chamber 120 so that the injection device 30 can be aligned with the anticancer drug vial 3 position of the drug supply unit 20.
  • the anticancer agent vial 30 is installed under the first fixing member 210 and the second fixing member 220 of the chemical supply unit 20 according to the operation of the second fixing member 210 and the second fixing member 220. It is installed so as to correspond to the position of the arrangement.
  • the injection device 30 is a syringe 310 for extracting and injecting an anticancer agent, a rotating part 320 to enable the syringe 310 to rotate in the direction of the drug supply unit 20, the syringe 310 is a drug supply unit ( The first linear 330 to perform a linear movement in the 20) direction, and the second linear 340 to linearly move for the piston operation of the syringe 310.
  • the syringe 310 is able to extract the anticancer agent from the anticancer agent vial 3 or inject the fluid into the position through the piston movement in the state in which the syringe needle is plugged into the anticancer agent vial 3.
  • the rotating part 320 is installed under the syringe 310 to rotate the syringe 310 to be positioned toward the position of the anticancer drug vial 3 installed in the medicine supply part 20.
  • the rotating part 320 is installed to rotate horizontally when viewed from the front.
  • the first linear 330 is installed above the rotating part 320, the syringe 310 is positioned to the position of the anticancer agent vial 3 installed in the first fixing member 210 or the second fixing member 22. It is a part that makes a linear motion so that it can be.
  • the first linear 330 may be a linear motion operation by a general LM guide driving method.
  • the second linear 340 is installed on the first linear 330 and attached to the piston of the syringe 310 to operate the piston of the syringe 310 so that the needle of the syringe 310 is the anticancer vial 3. It is inserted into the entrance of the anticancer drug can be extracted.
  • the second linear 340 may be injected into the mixing unit 50 after the syringe 310 is disposed in the mixing unit 50 position where the syringe 310 is rotated and mixed with the sap to be described later through the rotating unit 320.
  • the syringe 310 may rotate to the anticancer agent vial 3 or the mixing unit 50 position by the rotating unit 320, the anticancer agent vial 3 or the mixing unit 50 through the first linear 330. After approaching to the) position, the operation of extracting and injecting the anticancer agent through the second linear 330 may be implemented.
  • the fluid supply unit 40 is a portion for supplying the fluid required to be mixed with the anticancer agent extracted by the syringe 310 to be prepared as an anticancer injection.
  • the infusion supply unit 40 includes a sap bag installation unit 410, a first connection tube 420, a metering pump 430, and a second connection tube 44.
  • the infusion bag installation unit 410 is installed on the preparation chamber 120 of the sterile preparation table 10.
  • the sap bag installation unit 410 is formed so that the sap bag (2) in which the sap is stored to be installed in a vertical position in order to smoothly supply the sap.
  • the sap bag installation unit 410 may be formed in a ring on the sap bag (2), it may be formed in a bar shape horizontally so that the sap bag (2) can be easily fixed through the ring.
  • the infusion bag installation unit 410 is not limited to the form and may be configured in various forms as long as the infusion bag 2 can be installed so as to be disposed vertically in the preparation chamber 120.
  • the first connection tube 420 is connected to one side of the sap bag (2) is the portion to which the sap extracted from the sap bag (2) is transferred.
  • the metering pump 430 is connected to one side of the first connecting tube 420, the pumping and discharging so that the sap is extracted from the sap bag 2 by a predetermined amount through the first connecting tube 420 Play a role.
  • connection tube 440 is a portion for transferring the sap discharged from the metering pump 430 to the mixing unit 50.
  • a first connecting tube 420 is connected to the sap bag 2 installed in the sap bag installation unit 410, and one side of the first connecting tube 420 is connected to the metering pump 430.
  • One side of the second connection tube 440 is connected to the other side and the other side is installed to be connected to the mixing unit 50.
  • the quantitative pump 430 operates, the sap stored in the sap bag 2 is the first connection tube.
  • the 420 is introduced into the metering pump 430 and the sap can be transferred to the mixing unit 50 through the second connecting tube 440 by the pumping of the metering pump 430.
  • the quantitative sap can be injected into the mixing unit 50 by the quantitative pump 430.
  • first connecting tube 420 and the second connecting tube 440 is preferably a connector for connecting to the sap bag (2) and the like.
  • the metering pump 430 refers to a plunger-type pump used for accurately controlling a very small amount of material into a continuously flowing liquid, and the fluid flowing through the tube tube from one side to the other tube tube.
  • the mixing unit 50 is a portion for mixing and mixing the anticancer agent and the sap.
  • the mixing unit 50 is installed at one side of the preparation chamber 120 of the sterile preparation table 10, and is a portion for mixing the anticancer agent supplied from the injection device 30 and the sap supplied from the sap supply unit 40,
  • the mixing container 5 for accommodating the anticancer agent and the sap is provided.
  • the mixing unit 50 is provided with a container fixing part 510 to fix the mixing container 50, the first electronic balance 520 to check the weight of the anticancer agent and the sap contained in the mixing container (5) It is preferable to install this further.
  • the mixing container 5 installed in the mixing part 50 may be fixed by the container fixing part 510 in a preferably laid horizontal shape, and the injection amount of the anticancer agent and the sap injected into the mixing container 5.
  • the change in weight can be confirmed through the first electronic balance 520.
  • the anticancer agent is extracted from the drug supply unit 20 through the syringe 310 of the injection device 30, and the anticancer agent is injected into the mixing container 5 of the mixing unit 50 by the rotating unit 320, After injecting the quantitative amount of the sap into the mixing container 5 of the mixing part 50 through the supply part 40, the anticancer agent and the sap are collected and mixed in the mixing container 5 so that the anticancer injection can be prepared.
  • the shaker 60 is further installed to inject the sap into the anticancer agent stored in the anticancer agent vial 3 and to mix the anticancer agent in the sap solution. It is preferable.
  • the shaker 60 serves to make the powdered anticancer agent and the sap easily dissolved and mixed.
  • a second electronic balance 610 may be further installed to check whether the fluid is quantified, and the quantitative fluid is injected through the second electronic scale 610. After confirming that the shaker 60 is operated to mix the anticancer agent and the sap.
  • the anticancer agent described above when a large amount of anticancer injections are to be prepared using a large amount of anticancer drugs in addition to the anticancer agent vial (3), in order to inject a large amount of anticancer drugs into a mixed container, 4) is installed in the sap bag installation unit 410, the first connecting tube 420 is installed to be connected to one side of the anticancer agent bag (4), a large amount of anticancer agent by the operation of the metering pump 430 It may be injected into the mixing vessel (5) through the connecting tube (440).
  • an anticancer agent bag 4 containing a large amount of anticancer agent is installed, and the anticancer agent is injected into the mixing container 5 through the metering pump 430. Will be done.
  • an information input unit 70 may be further provided to store prescription information and anticancer drug preparation information as data.
  • the information input unit 70 largely includes a barcode printer 710, a barcode reader 720, and a touch screen 730.
  • the information input unit 70 is a part for receiving and inputting prescription information describing an anticancer injection drug component from a hospital computer network, and inputting information on the components of the prepared anticancer injection drug and storing it as data.
  • the barcode output unit 710 is a part for outputting the prescription information and the information on the components of the prepared anticancer injection drug delivered through the hospital network interlock as a barcode label.
  • the barcode reader 720 is a portion for reading the prescription information and the component information of the anticancer injection drug prepared as data to store.
  • the touch screen 730 displays and stores the information input through the bar code reader 720, and serves to transmit the information to the place where the anti-cancer injection drug and hospital hospital network.
  • the touch screen 730 includes an information processing and computing device in addition to a display function of displaying information, and may be, for example, in the form of an integrated PC.
  • the bar code reader 720 and the bar code output device 710 are configured to be used as a device for inputting and outputting through manipulation of the touch screen 730.
  • the prescription information is displayed and displayed on the touch screen 730 through the hospital computer network, and the pharmacist checks the prescription information and then records the prescription through the barcode printer 710.
  • the bar code label described is output and attached to the mixing container (5).
  • the result information of the anticancer drug preparation component is displayed on the touch screen 730, and the pharmacist outputs the information of the anticancer drug preparation component as a barcode and then the mixed container ( 5) Attach to.
  • the barcode reader 720 reads information about the anticancer drug preparation component and stores the data on the touch screen 730.
  • the pharmacist can check and compare the prescription information and the anticancer injection preparation information, and can store the history of the anticancer injection preparation for each patient as data.
  • the information input unit 70 may input and output the prescription information and the anticancer injection preparation information for the patient as a bar code, and output the data as a bar code so that accurate prescription and preparation for the patient may be performed in connection with the computer network. .
  • the installation position of the chemical supply unit 20, the injection device 30, the fluid supply unit 40, the mixing unit 50, the shaker 60, the information input unit 70 is installed in the aseptic preparation table 10 is limited It does not do but reveals that the fluid can be installed, and the injection device 30 is not limited to a specific position as long as the drug supply unit 20 and the mixing unit 50 can operate in conjunction.
  • the patient's prescription information is transmitted to and displayed on the touch screen 730 through the hospital computer network.
  • the pharmacist checks the information displayed on the touch screen 730, generates prescription information as a barcode, outputs the barcode label through the barcode printer 710, and attaches it to the mixed container 5 for the anticancer injection.
  • the barcode is read through the barcode reader 720 and stored as data.
  • the pharmacist fixes the mixing container 5 to the container fixing part 510 of the mixing part 50, and the anticancer and sap extraction and infusion data according to the prescription through the touch screen 730 drug supply unit 20 And to the injection device 30, the fluid supply unit 40 and the like to make the setting for the operation.
  • the pharmacist performs a task of attaching a prescription input and connector, and installing a medicine.
  • the drug supply unit 20 first supplies the anticancer drug.
  • the jig plate 212 is rotated around the rotating shaft 211, the anticancer vial 3 is the syringe 310 of the injection device 30 ) So that it can be arranged in line with the position.
  • the syringe 310 is rotated toward the anticancer agent vial 3 position by the rotating unit 320, and advanced to the anticancer agent vial 3 position by the first linear 330, and then the second linear 340 is moved.
  • the syringe 310 is operated through the needle to insert the syringe 310 into the anticancer agent vial 3 to extract the anticancer agent.
  • the first linear 330 is moved backward, and then the mixing unit ( The mixing container 5 of 50) rotates to a position where the anticancer agent is injected, and the needle 310 is inserted into the mixing container 5 to inject the extracted anticancer agent into the mixing container 5 as in the operation of extracting the anticancer agent. .
  • the weight of the anticancer agent and the sap injected into the mixing container 5 can be confirmed through the first electronic balance 520.
  • the sap for mixing with the anticancer agent injected into the mixing vessel (5) is the first connecting tube 420 from the sap bag (2) installed in the sap bag installation unit 410 by the operation of the metering pump 430 Through the metering pump 430 through the second connecting tube 440 is to be injected into the mixing vessel (5).
  • the anticancer agent bag 4 is installed in the sap bag installation unit 410 and the first connection tube 420 is connected to the anticancer agent bag 4 through a metering pump 430. It is possible to inject into the mixing vessel (5).
  • the anticancer agent vial 3 is placed in the second electronic balance 610 and then injected with sap to check the mixed weight of the anticancer agent and sap of the powder, and then through the shaker 60.
  • the powdered anticancer agent is mixed so that it can be easily dissolved, and the anticancer agent vial 3 in which the mixing of the anticancer agent and the sap is completed is transferred to the drug supply unit 20 and used.
  • the anticancer injection preparation information is output on the touch screen 730, and the pharmacist checks this information, and then outputs a barcode label containing the preparation result information and attaches the mixed container 5 to the barcode. Read data to the barcode reader 720 to store the data.
  • the finished anticancer injection is then delivered to an outpatient injection room and injected into the patient.
  • the anticancer agent of a certain amount is extracted from the anticancer agent vial 3 installed in the drug supply unit 20 through the injection device 30, and injected into the mixing container 5 installed in the mixing unit 50, and the metering pump ( 430 is extracted from the sap bag (2) installed in the sap supply unit 40 is injected into the mixing container (5) of the mixing section 50 to prepare an anticancer drug injection in which the quantitative anticancer agent and sap is mixed It becomes possible.
  • the anticancer agent when a large amount of anticancer agent is used, the anticancer agent is injected into the mixing container 5 of the mixing unit 50 by using the metering pump 430, and when a powdered anticancer agent is used, infusion of sap is made through the shaker 60.
  • the anticancer agent can be dissolved in the sap and mixed.
  • the automated facility minimizes the intervention of the pharmacist to reduce manpower, secures safety by reducing direct contact with the anticancer agent, and improves the accuracy of the anticancer injection preparation by mixing the quantitative anticancer agent and the sap. Is there.
  • FIG. 5 is a view showing the main configuration of the anticancer injection preparation device according to another embodiment of the present invention
  • Figure 6 and Figure 7 is an operating state showing the schematic operation of the anticancer injection preparation device according to another embodiment of the present invention to be.
  • the anticancer injection preparation device 1 according to another embodiment of the present invention further includes a lift unit 80 and a support unit 90.
  • the medicine supply unit 20 and the injection device 30 may be coupled to the lifting unit 80.
  • the lifting unit 80 may raise and lower the medicine supply unit 20 and the injection device 30.
  • the lifting unit 80 may be coupled to the first fixing member 210 on one side.
  • the drug supply unit 20 may be coupled to the first fixing member 210.
  • the drug supply unit 20 may rotate about the rotation shaft 211 in a state coupled to the first fixing member 210.
  • the lifting portion 80 may be coupled to the support portion 90 on the other side.
  • the lifting unit 80 may be coupled to the support unit 90 to be inserted into the support unit 90.
  • the drug supply unit 20 and the injection device 30 may be coupled to the lifting unit 80 to be located between one side and the other side of the lifting unit 80.
  • the lifting unit 80 may move the drug supply unit 20 and the injection device 30 in an upward direction or a downward direction.
  • the elevating part 80 may be partially or entirely inserted into the support part 90 to move the medicine supply part 20 and the injection device 30 downward.
  • the elevating unit 80 protrudes from the support unit 90 in a direction opposite to the direction of insertion into the support unit 90, thereby moving the drug supply unit 20 and the injection device 30 upward. have.
  • the lifting unit 80 may move the drug supply unit 20 and the injection device 30 downward when the anticancer injection agent is prepared in the sterile preparation table 10.
  • the pharmacist or anticancer injection agent is mounted on the lifting unit 80 or the lifting unit 80 through the open inlet of the aseptic preparation 10
  • the drug supply unit 20 can be removed from the unit 80 and removed.
  • the anticancer agent vials 3 of the drug supply unit 20 are empty. Can be. Therefore, the anticancer injection may be accommodated in the mixing container 5.
  • the lifting unit 80 may be moved downward after the syringe 310 is rotated by the rotating unit 320.
  • the syringe 310 may be rotated by the rotating part 320 in a vertical direction perpendicular to the vertical movement direction of the lifting part 80.
  • the lifting unit 80 may move the new drug supply unit 20 coupled to one side of the lifting unit 80 in the downward direction to be located to the open inlet of the aseptic preparation 10.
  • the elevating unit 80 protrudes from the support unit 90 such that the chemicals
  • the supply unit 20 and the injection device 30 may be moved upward.
  • the anticancer agent vials 3 of the new drug supply unit 20 may be the new anticancer agent vials 3 filled with the anticancer agent installed on the first fixing member 210 by a pharmacist or a pharmacist.
  • the lifting unit 80 may move the new drug supply unit 20 and the injection device 30 upward to prepare an anticancer injection from the new drug supply unit 20.
  • the mixing container 5 into which the anticancer injection is injected may also be replaced by a pharmacist or a formulator with a new mixing container 5 having an empty inside.
  • the elevating unit 80 moves the drug supply unit 20 and the injection device 30 upward, the syringe 310 rotated in the vertical direction again extracts an anticancer agent from the anticancer agent vial 310.
  • Direction can be rotated.
  • the lifting unit 80 may be formed in a cylindrical shape, but is not limited thereto, and may be formed in another shape such as a rectangular parallelepiped if the medicine supply unit 20 and the injection device 30 can be elevated.
  • the lifting unit 80 is a cylinder method using a hydraulic cylinder or a pneumatic cylinder, a gear method using a motor and a rack gear and a pinion gear, a ball using a motor and a ball screw, etc.
  • the chemical supply unit 20 and the injection device 30 may be moved upward and downward by using a screw method, a belt method using a motor, a pulley and a belt, or a linear motor method using a coil and a permanent magnet. Can be.
  • the lifting unit 80 may include an Lm block moving along an Lm guide rail installed in the support unit 90.
  • the support 90 is installed on the aseptic preparation table 10.
  • the support 90 may be installed on the aseptic preparation 10 so as to be located between the metering pump 430 and the second electronic balance 610.
  • the lifting unit 80 may be coupled to the support unit 90 to be insertable.
  • the support 90 may be supported by the aseptic preparation table 10 to support the lifting unit 80.
  • the support portion 90 may be formed as a rectangular parallelepiped in an overall shape, but is not limited thereto.
  • the support portion 90 may support the lifting portion 80, and part or all of the lifting portion 80 may be inserted into the support body 90. If possible, it may be formed in other shapes such as trapezoidal shape with an empty interior.
  • the anticancer injection preparation device 1 can place the drug supply unit 20 to the open inlet of the sterile preparation 2 after the preparation of the anticancer injection is completed.
  • the pharmacist or the pharmacist can easily remove the medicine supply unit 20 from the lifting unit 80 through the open inlet or easily install the lifting unit 80. Therefore, the anticancer injection preparation device 1 according to another embodiment of the present invention can prevent an industrial accident such as a musculoskeletal disorder from occurring in a pharmacist or a preparation person.
  • FIG. 8 is a schematic operation state diagram showing an anticancer injection preparation system according to the present invention.
  • the anticancer injection preparation system 1000 may include a supply unit 1100, an anticancer injection preparation device, a transfer robot 1200, and an export unit 1300. Since the anticancer injection preparation device is substantially the same as the anticancer injection preparation device 1 according to the present invention described above, a detailed description thereof will be omitted.
  • the supply unit 1100 has a plurality of anticancer vials containing an anticancer agent is fixed to any one of the plurality of anticancer vials to supply the drug supply unit 20 for supplying the anticancer agent, and the mixing vessel 5 for mixing the anticancer agent and the sap It is to supply.
  • the supply unit 1100 is the drug supply unit from the outside of the sterile preparation table 2 to the supply transfer area (SA, shown in Figure 8) that the transfer robot 1200 can be transferred to the anticancer injection preparation device (1) (20) and the mixing vessel (5) for supplying. That is, the supply unit 1100 is installed to connect the outside of the sterile preparation table 2 with the supply transfer area SA of the transfer robot 1200.
  • the feed transfer area SA of the transfer robot 1200 may be moved by holding the chemical supply unit 20 and the mixing vessel 5 supplied from the supply unit 1100 by the transfer robot 1200 formed of multiple joints. It means the area that can be.
  • the supply unit 1100 is the drug supply unit 20 and the mixing vessel (5) supplied by the pharmacist or formulator from the outside of the sterile preparation table (2) to the supply transfer area (SA) of the transfer robot 1200 Can supply
  • the supply unit 1100 may be a conveyor capable of supporting and moving the chemical supply unit 20 and the mixing container 5.
  • a pharmacist or pharmacist located outside of the sterile dispensing table 2 may supply the supply unit 1100 with a medicine supply unit 20 containing other types of anticancer agents according to a patient's prescription.
  • the supply unit 1100 may move a plurality of pairs of the chemical supply unit 20 and the mixing vessel (5).
  • the supply unit 1100 by sequentially placing a plurality of drug supply unit 20 and the mixing vessel (5) set by the pharmacist or formulator differently from the outside of the sterile preparation table 2, a plurality of The chemical supply unit 20 and the mixing container 5 may be sequentially moved to the supply transfer area SA.
  • the supply unit 3 supplies a pair of chemical supply unit 20 and the mixing vessel 5 to the supply transfer area SA, the transfer robot 1200 is the pair of chemical supply unit 20 and the mixing vessel ( Rotation may be stopped until 5) is transferred to the anticancer injection preparation device 1.
  • the supply unit 3 is located in the supply transfer area SA after the transfer robot 1200 transfers the pair of drug supply units 20 and the mixing container 5 to the anticancer injection preparation device 1 again. Can rotate.
  • the transport robot 1200 transfers the drug supply unit 20 and the mixing container 5 supplied from the supply unit 1100 to the anticancer injection preparation device 1 or the drug supply unit from the anticancer injection preparation device 1.
  • the transfer robot 1200 is a multi-joint robot, the length of which is extended or shortened through the movement of the articulated joints to hold or grasp items such as chemical supply unit and the mixing vessel.
  • the transport robot 1200 is fixedly installed on the floor and rotated, thereby quickly moving items located in different directions to different locations.
  • the transfer robot 1200 grips the drug supply unit 20 and the empty mixing container 5 containing the anticancer agent supplied from the supply unit 1100 in the supply transfer area SA. It can be transferred to the anticancer injection preparation device 1.
  • the transport robot 1200, the anticancer injection preparation device (1) by holding the drug supply unit 20 containing a mixed container (5) and empty anticancer drug vials prepared by receiving an anticancer injection drug (1) ) May be transferred to the carry-out unit 1300.
  • the transfer robot 1200 may transfer the drug supply unit 20 and the mixing container 5 to the export transfer area (CA, shown in Figure 8).
  • the carry-out transport area CA is an area in which the carry-out part 1300 is installed, and the medicine supply part 20 and the mixing container 5 transferred from the anticancer injection preparation device 1 by the transport robot 1200. Is an area to be placed on the carry-out unit 1300.
  • the transport robot 1200 rotates between the supply unit 1100 and the anticancer injection preparation device 1, and the anticancer injection preparation device 1 and the discharge unit 1300 to supply a medicine supply unit 20 and a mixing container. (5) can be transported. Although not shown, the transfer robot 1200 is incorrectly prescribed by the pharmacist or pharmacist, if the drug supply unit 20 is transferred through the supply unit 1100, incorrectly prescribed drug supply unit 20 in the supply unit 1100 It may be transferred to the carrying out portion 1300 immediately by holding.
  • the transport robot 1200 may be installed to be positioned in the middle of the anticancer injection preparations 1 when a plurality of anticancer injection preparations 1 are installed. That is, the anticancer injection preparation devices 1 may be installed such that the separation distance DL (shown in FIG. 8) spaced apart from the transport robot 1200 is the same. Accordingly, the anticancer injection preparation system 1000 according to the present invention is rotated in a fixed state on the floor even if the transfer robot 1200 does not move to each anticancer injection preparation device 1, thereby providing a Rapidly transfer the drug supply unit 20 and the mixing vessel 5 to the respective anticancer injection preparations 1 or the drug supply unit 20 and from the anticancer injection preparations 1 to the discharge unit 1300.
  • the mixing container 5 can be conveyed quickly.
  • the transfer robot 1200 grips the drug supply unit 20 and the mixing vessel 5 supplied from the supply unit 1100 in the supply transfer area SA, thereby raising and lowering the anticancer injection preparation device 1 ( 80) and the container fixing portion 510 may be provided with the chemical supply unit 20 and the mixing container (5), respectively.
  • the lifting unit 80 may be in a state moved downward to the open inlet of the aseptic preparation 10.
  • the elevating unit 80 may move the chemical supply unit 20 in an upward direction when the chemical supply unit 20 is installed by the transfer robot 1200.
  • the anticancer injection preparation device 1 may prepare an anticancer injection.
  • the drug supply unit 20 may be gripped from the lift unit 80 through the open inlet of the sterile preparation table 10 and then transferred to the discharge unit 1300.
  • the transfer robot 1200 may grip the mixed container 5 containing the anticancer injection agent from the container fixing part 510 and transfer the same to the discharge unit 1300.
  • the carrying out unit 1300 is for carrying out the medicine supply unit 20 and the mixing container 5 in which the anticancer injection agent is transferred from the anticancer injection preparation device 1 by the transfer robot 1200.
  • the carrying out unit 1300 is installed to connect the carrying out area CA and the outside.
  • the carrying out unit 1300 may carry the chemical supply unit 20 and the mixing container 5 transported by the transfer robot 1200 to be carried out to the outside.
  • the carrying out unit 1300 may be a conveyor that rotates between the carrying out area CA and the outside.
  • the carrying out unit 1300 may carry out a pair of chemical supply unit 20 and the mixing vessel (5) made to be sequentially transferred from the transfer robot 1200 to the outside.
  • the mixed container 5 containing the anticancer injection taken out from the carrying out unit 1300 may be moved to another place such as an injection room or a pharmacy by a pharmacist or a pharmacist.
  • the drug supply unit 20 including empty anticancer vials to be taken out from the carrying out unit 1300 may be moved to a washing unit or a recycling unit for reusing the anticancer agent vials.
  • the anticancer injection preparation system 1000 according to the present invention can achieve the following effects.
  • the anticancer injection preparation system 1000 is provided by connecting the supply unit 1100 and the export unit 1300 to the supply transfer area SA and the export transfer area CA, respectively.
  • the anticancer injection preparation device 1 can easily supply and discharge the drug supply unit 20 and the mixing container (5). Accordingly, the anticancer injection preparation system 1000 according to the present invention not only prevents industrial accidents such as musculoskeletal disorders from occurring in the pharmacist or pharmacist, but also contaminates the anticancer injection preparation device 1 for preparing the anticancer injection. It is possible to prevent the substance from penetrating.
  • the anticancer injection preparation system 1000 quickly supplies the medicine supply unit 20 and the mixing container 5 to each of the plurality of anticancer injection preparations 1 by using the transfer robot 1200. Since it can discharge, a large amount of anticancer injections can be prepared quickly.
  • the anticancer injection preparation system 1000 may install a transfer robot in the supply unit 1100 and the export unit 1300, respectively, to fully automate the preparation of the anticancer injection.
  • the anticancer injection preparation system 1000 according to the present invention includes a mixing container 5 as well as a plurality of anticancer drug vials 3 in the drug supply unit 20, so that the transport robot 1200 is a single drug transporting.
  • the supply unit 20 and the mixing container 5 may be supplied to or discharged from the anticancer injection preparation device 1. Accordingly, the anticancer injection preparation system 1000 according to the present invention shortens the time for supplying and discharging the drug supply unit 20 and the mixing container 5 to the anticancer injection preparation device 1, thereby preparing an anticancer injection. The time taken can be further shortened.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

La présente invention concerne un dispositif de préparation d'injection anticancéreuse et, plus particulièrement, un dispositif de préparation d'injection anticancéreuse et un système de préparation d'injection anticancéreuse le comprenant. Des quantités prédéterminées d'agent anticancéreux et de perfusion peuvent être extraites et utilisées pour préparer une injection anticancéreuse à travers une installation automatisée tout en réduisant au minimum les déchets de médicaments. A cet effet, l'invention concerne un dispositif de préparation d'injection anticancéreuse comprenant: une table de préparation aseptique installée à l'intérieur d'une chambre aseptique et pourvue d'une chambre de préparation dans laquelle une injection anticancéreuse est préparée; une partie d'alimentation en médicament installée sur la table de préparation aseptique, une pluralité de flacons d'agent anticancéreux qui contiennent un agent anticancéreux qui est fixé à la partie d'alimentation en médicament de telle sorte que l'un est choisi parmi la pluralité de flacons d'agent anticancéreux, fournissant ainsi l'agent anticancéreux; un dispositif d'injection actionné de telle sorte que celui-ci peut être aligné avec la position d'un flacon d'agent anticancéreux installé sur la partie d'alimentation en médicament, le dispositif d'injection étant configuré pour extraire l'agent anticancéreux du flacon d'agent anticancéreux installé sur la partie d'alimentation en médicament et pour injecter l'agent anticancéreux extrait dans un endroit où une perfusion est contenue; une partie d'alimentation en perfusion installée sur la table de préparation aseptique de façon à fournir une perfusion qui est mélangée à l'agent anticancéreux; et une partie de mélange pourvue d'un récipient de mélange de manière à mélanger l'agent anticancéreux fourni par le dispositif d'injection et la perfusion fournie par la partie d'alimentation en perfusion.
PCT/KR2017/008039 2015-12-09 2017-07-26 Dispositif de préparation d'injection anticancéreuse et système de préparation d'injection anticancéreuse le comprenant WO2018021816A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20150174659 2015-12-09
KR1020160094930A KR20170068368A (ko) 2015-12-09 2016-07-26 항암 주사제 조제장치 및 이를 포함하는 항암 주사제 조제시스템
KR10-2016-0094930 2016-07-26

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112495849A (zh) * 2020-12-31 2021-03-16 安徽联谊药业股份有限公司 一种西药学用注射药剂筛选器

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050087562A1 (en) * 2003-10-08 2005-04-28 Akira Koide Mixed liquid manufacturing apparatus
US20080169044A1 (en) * 2006-10-20 2008-07-17 Forhealth Technologies, Inc. Automated drug preparation apparatus including syringe loading, preparation and filling
KR20110106671A (ko) * 2010-03-23 2011-09-29 재단법인 포항지능로봇연구소 주사제 준비장치 및 주사제 준비방법
US20130085467A1 (en) * 2011-09-27 2013-04-04 Board Of Regents, The University Of Texas System Robotic infusion mixer and transportable cartridge
KR20160058070A (ko) * 2013-09-19 2016-05-24 가부시키가이샤 유야마 세이사쿠쇼 혼주 장치, 혼주 방법

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050087562A1 (en) * 2003-10-08 2005-04-28 Akira Koide Mixed liquid manufacturing apparatus
US20080169044A1 (en) * 2006-10-20 2008-07-17 Forhealth Technologies, Inc. Automated drug preparation apparatus including syringe loading, preparation and filling
KR20110106671A (ko) * 2010-03-23 2011-09-29 재단법인 포항지능로봇연구소 주사제 준비장치 및 주사제 준비방법
US20130085467A1 (en) * 2011-09-27 2013-04-04 Board Of Regents, The University Of Texas System Robotic infusion mixer and transportable cartridge
KR20160058070A (ko) * 2013-09-19 2016-05-24 가부시키가이샤 유야마 세이사쿠쇼 혼주 장치, 혼주 방법

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112495849A (zh) * 2020-12-31 2021-03-16 安徽联谊药业股份有限公司 一种西药学用注射药剂筛选器
CN112495849B (zh) * 2020-12-31 2023-10-13 安徽联谊药业股份有限公司 一种西药学用注射药剂筛选器

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