WO2018021435A1 - Composition comprenant de l'hydrogène en tant que composant actif, pour améliorer l'endurance à l'effort ou pour soulager la fatigue perçue après l'effort - Google Patents

Composition comprenant de l'hydrogène en tant que composant actif, pour améliorer l'endurance à l'effort ou pour soulager la fatigue perçue après l'effort Download PDF

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Publication number
WO2018021435A1
WO2018021435A1 PCT/JP2017/027106 JP2017027106W WO2018021435A1 WO 2018021435 A1 WO2018021435 A1 WO 2018021435A1 JP 2017027106 W JP2017027106 W JP 2017027106W WO 2018021435 A1 WO2018021435 A1 WO 2018021435A1
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hydrogen
exercise
gas
composition
fatigue
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PCT/JP2017/027106
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English (en)
Japanese (ja)
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耕平 田野
太田　成男
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株式会社マイトス
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Priority to JP2018530367A priority Critical patent/JPWO2018021435A1/ja
Publication of WO2018021435A1 publication Critical patent/WO2018021435A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism

Definitions

  • the present invention relates to a composition that improves exercise endurance or reduces fatigue after exercise.
  • Examplercise endurance is the ability to keep exercising for a long time, and people with low endurance are reported to have higher mortality than those with high endurance.
  • exercise endurance has a strong correlation with the amount of physical activity, and if the amount of physical activity is increased, obesity and the like are prevented, and it is considered effective for preventing lifestyle-related diseases.
  • fatigue endurance after exercise can be reduced by improving exercise endurance.
  • the present invention aims to provide a composition that improves exercise endurance or reduces fatigue after exercise.
  • the present inventor has intensively studied the effect of hydrogen on exercise endurance or the effect of reducing fatigue after exercise. Specifically, the subject was ingested with hydrogen water once, and how the endurance of exercise changed was confirmed by using a change in the maximum oxygen intake or a change in the subjective exercise intensity index as an index.
  • the present invention is as follows.
  • RPE subjective exercise intensity
  • the present invention is a composition containing hydrogen as an active ingredient for improving exercise endurance or reducing fatigue after exercise.
  • composition for improving exercise endurance containing hydrogen or reducing fatigue after exercise of the present invention may be a liquid or a gas.
  • “Exercise endurance” refers to the ability to continue exercise longer. By improving exercise endurance, fatigue after exercise can be reduced. Therefore, reducing fatigue after exercise and improving exercise endurance represent the same phenomenon.
  • Exercise endurance can be measured, for example, by maximum oxygen intake.
  • the maximum oxygen uptake is a value representing the maximum oxygen uptake (mL / kg / min) per unit time that can be taken by an individual as measured by incremental exercise. Usually measured with a treadmill with a motor. Maximum oxygen uptake is used as an indicator of endurance.
  • exercise endurance can be expressed as an index of the subjective exercise intensity that the person is aware of.
  • the subjective exercise intensity is an index that expresses how hard the exercise intensity felt by the subjectivity of the exercise practitioner, and is expressed by Borg's subjective exercise intensity (Borg scale) (Fig. 1). be able to.
  • Borg's subjective exercise intensity is represented by an index of 15 levels from 6 to 20 (6 is not shown in FIG. 1). Category 1 level corresponds to a heart rate of 10 bpm.
  • the index of the subjective exercise intensity is determined to be smaller even when exercise of the same intensity is performed.
  • This VAS test can evaluate fatigue after exercise and determine the degree of fatigue reduction.
  • the liquid containing hydrogen molecules is an aqueous solution.
  • a liquid containing hydrogen may be referred to as hydrogen water.
  • a medium for forming this aqueous solution pure water, ion-exchanged water, distilled water, physiological saline, or the like can be used.
  • pure water, ion-exchanged water or distilled water is used as the medium, and the resulting in vivo harmful free radical scavenger is applied to general aqueous beverages such as mineral water, juice, coffee, tea, etc. You may make it add and drink.
  • the beverages include health foods for beverages, functional display foods, foods for specific health, functional nutritional foods, and the like.
  • the food for specified health refers to food that is ingested for the purpose of specific health in the diet and displays that the purpose of the health can be expected by the intake.
  • These beverages may have a display indicating that they are used for improving exercise endurance or reducing fatigue after exercise, for example.
  • Hydrogen molecules can be dissolved in water or an aqueous solution for a certain period of time even in a saturated state.
  • Such water or an aqueous solution saturated with hydrogen molecules can be easily produced by removing the pressure after dissolving hydrogen gas in water or an aqueous solution under pressure.
  • the aqueous solution may be kept under hydrogen gas pressure of 0.4 MPa or more for several hours, preferably 1 to 3 hours. Or you may manufacture in a short time with the apparatus which manufactures hydrogen water in large quantities.
  • Hydrogen water in the form of an aqueous solution can be used for drinking, and can also be used for intravenous injection in the form of physiological saline. In this case, administration can be performed using a catheter or by injection. After the injection, most of the hydrogen taken into the living body is absorbed by the living body, spreads throughout the body via blood, exerts its effect, and is then discharged together with exhaled breath.
  • Hydrogen can be dissolved at about 17.5mL per liter of water at about 1 atmosphere of hydrogen and room temperature (about 1.6ppm, about 0.8mm).
  • the liquid composition containing hydrogen molecules of the present invention contains 10 mL or more, preferably 15 mL or more, particularly preferably 17.5 mL or more of hydrogen molecules per liter of the aqueous solution.
  • the liquid composition containing hydrogen molecules of the present invention contains 0.8 ppm or more, preferably 1 ppm or more, more preferably 1.1 ppm or more, and further preferably 1.2 ppm or more.
  • the liquid composition containing hydrogen molecules of the present invention contains 0.1 mM or more, preferably 0.4 mM or more, more preferably 0.6 mM, and particularly preferably 0.8 mM or more.
  • the liquid composition containing hydrogen molecules of the present invention may contain oxygen molecules. Hydrogen molecules and oxygen molecules coexist in the aqueous solution, but even if the hydrogen molecules and oxygen molecules are in a mixed state, they do not react immediately, and both can coexist stably.
  • the hydrogen content is preferably less than 4% (v / v) of the total gas in order to ensure safety. In an environment where there is no problem with safety, the hydrogen content is preferably as high as possible.
  • Liquid compositions containing oxygen can also be used for intravenous administration in the form of drinking or saline, but when administered by injection, the body is locally deficient in oxygen compared to the absence of oxygen molecules. Therefore, the biological tissue is less likely to be damaged.
  • the liquid composition of the present invention is preferably stored in a container made of a material that cannot permeate hydrogen, such as aluminum. Further, since the hydrogen is dissolved at a lower temperature, it is preferably stored at a lower temperature.
  • the liquid composition of the present invention may be taken in an amount of 100 to 5000 mL, preferably 150 to 2000 mL, more preferably 150 to 1000 mL, and more preferably 200 to 750 mL.
  • the effect of improving exercise endurance or the effect of reducing fatigue after exercise can be obtained by taking 1 to several times.
  • the above-mentioned amount per day may be taken for 1 day to several years, preferably several months to several years, more preferably 6 months to 2 years, and further preferably 6 months to 1 year.
  • the gas composition containing hydrogen molecules contains hydrogen gas.
  • the concentration of hydrogen gas contained in the gas composition of the present invention is 1 to 4% (v / v), preferably 2.5 to 3.5% (v / v), more preferably about 3%.
  • the hydrogen gas content is preferably less than about 4% (v / v) to ensure safety.
  • hydrogen gas is contained under safe conditions that prevent static electricity from being generated under sealed conditions. The amount can be higher.
  • the gas composition containing hydrogen gas of the present invention as an active ingredient may further contain oxygen gas and / or other inert gas. When oxygen gas is included, it consists of a mixed gas of hydrogen gas and oxygen gas. Oxygen gas is consumed for breathing.
  • Nitrogen gas, helium gas, argon gas or the like can be used as the inert gas, but inexpensive nitrogen gas is desirable.
  • the content of the inert gas can be arbitrarily set by those skilled in the art within a range not too much, but is preferably 80% (v / v) or less in consideration of the concentration of oxygen gas for respiration.
  • the composition containing the hydrogen gas of the present invention as an active ingredient may be a mixed gas of hydrogen gas and air. Such a mixed gas can be easily produced by appropriately mixing hydrogen gas with air.
  • the gas composition containing the hydrogen gas of the present invention as an active ingredient may contain an anesthetic gas.
  • the gas composition containing hydrogen gas as an active ingredient consists of a mixed gas of hydrogen gas and anesthetic gas.
  • Anesthesia gas includes laughing gas.
  • the gas composition containing the hydrogen gas of the present invention as an active ingredient is placed in a pressure-resistant container such as a gas cylinder.
  • the present invention also includes a container containing a gas composition containing hydrogen gas as an active ingredient.
  • the gaseous composition containing the gaseous hydrogen gas of the present invention as an active ingredient can be inhaled by the subject.
  • the suction can be performed using a suction means, and it may be sucked through a pipe from a container containing a gas composition containing hydrogen gas as an active ingredient through the suction means.
  • the suction means is not limited, but includes, for example, a suction mask, which can preferably cover the patient's mouth and nose simultaneously.
  • the small chamber is large enough to allow a patient to enter the chamber. With the patient in the small chamber, the hydrogen gas of the present invention is placed in the small chamber.
  • By supplying a gas composition containing as an active ingredient the patient can be aspirated.
  • An example of such a small room is a sealed bed. The patient can inhale the gaseous composition containing the hydrogen gas of the present invention as an active ingredient while lying on the bed.
  • the present invention includes a container containing a gas composition containing hydrogen gas as an active ingredient, a gas suction means, and a supply pipe for supplying the gas in the container to the suction means, and contains hydrogen gas as an active ingredient.
  • a device for supplying a gaseous composition to a subject is, for example, a hydrogen gas cylinder.
  • the gas suction means includes a suction mask and a sealed chamber.
  • the apparatus may further include a container containing at least one gas selected from the group consisting of oxygen gas, inert gas, air, and anesthetic gas, and in this case, a gas containing hydrogen gas as an active ingredient
  • a gas suction bag containing hydrogen gas may be directly connected to the suction mask, and hydrogen gas may be supplied from a gas cylinder containing hydrogen gas to the gas suction bag.
  • FIG. 5 shows a schematic diagram of the apparatus of the present invention.
  • the figure shows gas suction means 1, container 2 containing a therapeutic agent for acute cerebral infarction containing hydrogen gas as an active ingredient, at least one selected from the group consisting of oxygen gas, inert gas, air and anesthetic gas
  • the container 3 containing the gas and the pipe 4 are provided, and the gas is supplied to the gas suction means through the pipe and administered to the patient.
  • Administration of the gaseous composition containing hydrogen gas as an active ingredient may be performed once for 0.1 to 5 hours, preferably 0.5 to 2 hours, more preferably 1 hour.
  • the effect of improving exercise endurance or the effect of reducing fatigue after exercise can be obtained by administration once to several times.
  • 1 to 5 times per day, preferably 1 to 3 times, more preferably 2 times, several days to several years, preferably several months to several years, more preferably 6 months to It may be administered for 2 years, more preferably 6 months to 1 year.
  • the suction speed when administering hydrogen gas is, for example, several liters per hour, preferably about 6 liters.
  • the composition of the present invention also includes a composition that stores and holds hydrogen atoms or contains a substance that generates hydrogen as an active ingredient.
  • a substance that stores and holds hydrogen atoms or generates hydrogen it is fine particles of metal or metal alloy that stores and holds hydrogen or generates hydrogen.
  • hydrogen includes atomic hydrogen and molecular hydrogen.
  • the hydrogen storage metal examples include lithium (Li), magnesium (Mg), calcium (Ca), vanadium (V), and lanthanum (La).
  • the hydrogen storage metal or metal alloy includes the metal and its alloys that can store hydrogen by combining with hydrogen to form a hydride. Among these, magnesium or its alloy is desirable.
  • a metal compound that occludes hydrogen is referred to as a metal hydride compound.
  • magnesium that occludes hydrogen is referred to as magnesium hydride (MgH 2 ).
  • Magnesium hydride is safe because it reacts with moisture to generate molecular hydrogen, and the rest becomes Mg (OH) 2 .
  • Atomic hydrogen generated from MgH 2 reduces the contacted oxidant (for example, indicated by X in the following chemical formula) by the following formula.
  • the remaining Mg reacts with H 2 O to become Mg (OH) 2 .
  • the fine particles of the hydrogen storage metal or metal alloy of the present invention have an average particle size of 0.5 ⁇ m to 10 ⁇ m, preferably 1 ⁇ m to 5 ⁇ m, more preferably 1 ⁇ m to 3 ⁇ m.
  • the fine particles can be made finer (nanoized) and used as nanometer-sized nanoparticles.
  • the size of the nanoparticles is an average particle size of 5 to 500 nm, preferably 10 to 100 nm.
  • the hydrogen storage metal or metal alloy can be produced by bonding hydrogen to a metal, and can be produced by a known method. For example, pressure may be applied in the presence of metal and hydrogen.
  • the obtained hydrogen storage metal or metal alloy may be pulverized by powder collision or the like.
  • MgH 2 does not react with oxygen in the air in a short time unlike metallic Mg, it is pulverized by repeated collisions between particles. Particles of a specific size are produced according to the collision speed and collision frequency. For example, further fine pulverization is possible by a method in which MgH 2 fine particles are inert gas (for example, nitrogen) as a carrier gas in a closed container and the particles collide with each other or collide with a wall surface. At this time, MgH 2 fine particles having a desired size can be obtained by controlling the pressure of the carrier gas in the circumferential direction, the gas flow rate, and the input amount of the MgH 2 powder.
  • inert gas for example, nitrogen
  • MgH 2 fine particles having a particle size smaller than the target particle size gather in the center as the particle size becomes smaller. And it is accompanied by carrier gas and discharged
  • hydrogen storage metal or metal alloy The fine particles can be further finely divided.
  • molecular hydrogen By reacting with water, molecular hydrogen can be generated according to the following reaction formula. MgH 2 + 2H 2 O ⁇ Mg (OH) 2 + 2H 2
  • the hydrogen storage metal or metal alloy fine particles may be contained in the resin, and the present invention also includes a composition containing, as an active ingredient, a resin containing metal or metal alloy fine particles storing and holding hydrogen.
  • a resin containing fine particles of a metal or metal alloy that occludes and holds hydrogen can generate hydrogen and release it.
  • the present invention is a hydrogen releasing agent or a hydrogen generating agent containing a resin containing fine particles of a metal or metal alloy that occludes and holds hydrogen.
  • Mg (OH) 2 itself is not a harmful substance for living organisms, it is not preferable to be mixed in drinking water or food. Therefore, in the resin containing the hydrogen storage alloy of the present invention, Mg produced by generating hydrogen ( OH) 2 is encapsulated in the resin and does not exit the resin.
  • the resin containing a hydrogen storage metal or metal alloy examples include polyethylene, polyethylene terephthalate, polypropylene, vinyl chloride, polystyrene, polycarbonate, polyester, polymethylpentene, styrene, acrylic, nylon, and fluororesin.
  • the resin to be used is a resin that can be used as a material for a container in which food is placed, or can be used as a material for a film or sheet for packaging food.
  • Examples of the method of adding a hydrogen storage metal or metal alloy to the resin include, for example, a resin such as methanol, ethanol, isopropyl alcohol, cyclohexane, trichloroethylene, dichloromethane, benzene, ethyl acetate, butyl acetate, acetone, toluene, xylene,
  • a resin such as methanol, ethanol, isopropyl alcohol, cyclohexane, trichloroethylene, dichloromethane, benzene, ethyl acetate, butyl acetate, acetone, toluene, xylene.
  • a hydrogen storage metal or metal alloy such as MgH 2 is put in an organic solvent, a resin such as polystyrene or polyethylene is added and dissolved therein, and the hydrogen storage metal or metal alloy is suspended in the dissolved resin. Next, by evaporating the organic solvent, a resin containing a hydrogen storage metal or metal alloy can be produced.
  • the resin containing a hydrogen storage metal or metal alloy can be processed into an arbitrary shape. For example, it can be processed into particles, granules, sheets, and films.
  • the resin containing the hydrogen storage metal or metal alloy of the present invention can release hydrogen over 1 day or more, preferably 3 days or more, more preferably 1 week or more, and particularly preferably 2 weeks or more.
  • the hydrogen storage metal or metal alloy can release hydrogen at a high temperature, for example, 270 ° C. or higher, but does not release hydrogen when humidity is controlled to be low at normal temperature and pressure. Further, since the resin hardly permeates water, when the hydrogen storage metal or metal alloy is stored at room temperature and normal pressure, it is 1 year or longer, preferably 3 years or longer, more preferably 5 years or longer, particularly preferably 10 years or longer. Hydrogen is not released and disappears.
  • water can be produced by putting water in a container such as a cup and adding the resin containing the inventive hydrogen storage metal or metal alloy to generate hydrogen.
  • a composition containing a substance that occludes and holds hydrogen atoms as an active ingredient may be administered to a subject after generating hydrogen and making it into a hydrogen gas or hydrogen water state.
  • composition for improving exercise endurance containing hydrogen as an active ingredient of the present invention is aware of a decrease in exercise endurance, hopes to improve exercise endurance, or reduces fatigue after exercise. It may be administered or ingested to the desired subject.
  • composition of the present invention containing hydrogen as an active ingredient can improve exercise endurance or reduce fatigue after exercise, thereby improving exercise endurance and reducing fatigue after exercise.
  • the composition for improving exercise endurance containing hydrogen as an active ingredient of the present invention or reducing fatigue after exercise was effective, for example, improving exercise endurance containing hydrogen as an active ingredient, Alternatively, it can be confirmed by a change in the maximum oxygen intake before or after administration or ingestion of the composition that reduces fatigue after exercise, or a change in the subjective exercise intensity index. That is, after administering or ingesting a composition for improving exercise endurance containing hydrogen as an active ingredient, the maximum oxygen intake is 1.5 mL / kg / min or more, preferably 2.0 mL / kg / min or more, more preferably 3.0. Increase by more than mL / kg / min.
  • Borg's subjective exercise intensity (Borg scale) index decreases by 0.35 or more, preferably by 0.5 or more, and more preferably by 0.6 or more.
  • the feeling of fatigue after exercise may be evaluated by a fatigue VAS (Visual Analogue Scale) test.
  • Subjects obtained cooperation from volunteers who fully explained the purpose of the experiment and obtained their consent, considering the age and gender ratio.
  • test subjects are 12 in their 20s, 12 in their 30s, 12 in their 40s, 12 in their 50s and 12 in their 60s, and the male-female ratio is 30:30.
  • the hydrogen water group and placebo group were classified at random so that the age and gender ratio would be the same.
  • Drinking water Volunteers drank 500 mL of tap water at once, and started physical fitness measurement 10 minutes later.
  • people in the hydrogen water group took 500 mL of hydrogen water (1.0 ppm), and physical fitness was measured 10 minutes later.
  • People in the placebo group were given 500 mL of placebo water (tap water) in a hydrogen water container, and physical fitness was measured 10 minutes later.
  • Maximum oxygen uptake (VO 2 max, maximal oxygen consumption) is the maximum amount of oxygen consumption measured by incremental exercise, usually with a motor Measured with a treadmill. Maximum oxygen uptake reflects aerobic exercise capacity and is an important factor in determining long-term maximum exercise endurance.
  • the maximum oxygen consumption was measured according to a conventional method. The principle is to run a motorbike at a constant speed (60 rpm) and measure the pulse. The load was increased stepwise in three steps, and the pulse at the maximum load was estimated by increasing the pulse rate at that time, and the maximum oxygen consumption (VO 2 max) (mL / kg / min) was obtained. Exercise time is 11 minutes.
  • the Anti-Fatigue Clinical Evaluation Guidelines (The Japanese Society of Fatigue, July 22, 2011) recommends using VASVA (Visual Analogue Scale) for fatigue. This method is based on a number of questions written on the inspection sheet. From the “best sense of no fatigue” at the left end of the straight line to the “worst sense of exhaustion that can do nothing” at the right end. Then, enter x to make a decision (http://hirougakkai.com/hyouka.pdf Anti-fatigue clinical evaluation guidelines).
  • VASVA Visual Analogue Scale
  • composition of the present invention containing hydrogen as an active ingredient can be used for improving exercise endurance and reducing fatigue after exercise.
  • Gas suction means Container containing hydrogen gas
  • Container containing at least one gas selected from the group consisting of oxygen gas, inert gas, air and anesthetic gas 4 Piping

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Abstract

L'objectif de la présente invention est de fournir une composition pour améliorer l'endurance à l'effort ou pour soulager la fatigue perçue après l'effort. La présente invention est une composition comprenant de l'hydrogène en tant que composant actif, pour améliorer l'endurance à l'effort ou pour soulager la fatigue perçue après l'effort.
PCT/JP2017/027106 2016-07-27 2017-07-26 Composition comprenant de l'hydrogène en tant que composant actif, pour améliorer l'endurance à l'effort ou pour soulager la fatigue perçue après l'effort WO2018021435A1 (fr)

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JP2018530367A JPWO2018021435A1 (ja) 2016-07-27 2017-07-26 水素を有効成分として含む運動持久力を向上させ、又は運動後の疲労感を軽減させる組成物

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JP2016-147541 2016-07-27
JP2016147541 2016-07-27

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Cited By (2)

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JP2020028247A (ja) * 2018-08-22 2020-02-27 株式会社 伊藤園 疲労感軽減剤および疲労感軽減用飲食品組成物
WO2022123666A1 (fr) * 2020-12-09 2022-06-16 サスメド株式会社 Système d'aide à l'accoutumance à l'exercice et programme d'aide à l'accoutumance à l'exercice

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JP2014028714A (ja) * 2012-07-31 2014-02-13 Kracie Home Products Ltd 水素発生用組成物
JP2014532561A (ja) * 2012-08-27 2014-12-08 シームス バイオニックス インコーポレイテッド 酸性水電解槽及びその酸性水の利用方法
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JP2016088818A (ja) * 2014-11-07 2016-05-23 有限会社プレジール 水素水溶液および水素水溶液製造用キット、ならびに水素水溶液の製造方法

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020028247A (ja) * 2018-08-22 2020-02-27 株式会社 伊藤園 疲労感軽減剤および疲労感軽減用飲食品組成物
WO2022123666A1 (fr) * 2020-12-09 2022-06-16 サスメド株式会社 Système d'aide à l'accoutumance à l'exercice et programme d'aide à l'accoutumance à l'exercice
CN116529832A (zh) * 2020-12-09 2023-08-01 永续医疗株式会社 运动习惯养成支援系统及运动习惯养成支援用程序
CN116529832B (zh) * 2020-12-09 2024-03-26 永续医疗株式会社 运动习惯养成支援系统及运动习惯养成支援用程序

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