WO2018016998A1 - Composition biocide et procédés de traitement avec celle-ci de plantes et d'animaux - Google Patents

Composition biocide et procédés de traitement avec celle-ci de plantes et d'animaux Download PDF

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Publication number
WO2018016998A1
WO2018016998A1 PCT/RU2017/050002 RU2017050002W WO2018016998A1 WO 2018016998 A1 WO2018016998 A1 WO 2018016998A1 RU 2017050002 W RU2017050002 W RU 2017050002W WO 2018016998 A1 WO2018016998 A1 WO 2018016998A1
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WO
WIPO (PCT)
Prior art keywords
composition
biocidal
treatment
plants
plant
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PCT/RU2017/050002
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English (en)
Russian (ru)
Inventor
Вадим Альбертович КАСЬЯНЕНКО
Original Assignee
Вадим Альбертович КАСЬЯНЕНКО
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Publication of WO2018016998A1 publication Critical patent/WO2018016998A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
    • A01N31/02—Acyclic compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
    • A01N33/02—Amines; Quaternary ammonium compounds
    • A01N33/08—Amines; Quaternary ammonium compounds containing oxygen or sulfur
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
    • A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea

Definitions

  • the group of inventions relates to biocidal compositions and methods of their use for the treatment, prevention and protection of plants and warm-blooded animals (including humans) from fungal (fungal) and bacterial diseases.
  • US Pat. No. 4,435,381, 03/06/1984 discloses the use of thiuronium phosphates for dental hygiene of animals, and also refers to the use of thiuronium bromides as fungicides for treating plants.
  • US patent US2980578, 04/18/1961 discloses a method for fungicidal treatment of plants using a solution of isothiuronium chlorides and bromides.
  • the closest analogue of the invention is a biocidal composition and method of its use, disclosed in British patent GB 1551224, 08/30/1979.
  • the composition is an aqueous solution containing 0.001-10 wt.% S-substituted salt of thiuronium, as well as nonionic or cationic surfactants.
  • thiuronium salt a compound of the following formula is used:
  • Ro is aralkyl, alkanoid, aralkanoyl, aroyl and allyl, and X is halogen
  • the specified analogue also disclosed a method of antibacterial treatment of human skin, including applying the specified composition.
  • the described salts of thiuronium halides in the radical group contain a benzene or phenolic ring.
  • halogens such as chlorine or bromine
  • cyclic aromatic compounds When heated in the presence of halogens (such as chlorine or bromine) and atmospheric oxygen, cyclic aromatic compounds can form dioxin-like compounds and dioxin-like compounds that are dangerous to the health of living organisms (plants, animals, humans). Accordingly, there is a risk of the formation of these compounds during the synthesis of salts, which requires special control in the production and thorough purification of the substance.
  • the objective of the claimed group of inventions is to create an effective, safe for plants and animals and easy to manufacture biocidal composition.
  • the technical result of the invention is to increase the fungicidal and antibacterial properties of the composition, increase the efficiency and safety of biocidal treatment for plant and animal tissues, and also simplify the method of its production and use.
  • the specified technical result is achieved in a biocidal composition for treating tissues of living organisms due to the fact that it contains a thiuronium salt and a solvent, while it contains s-nonyl thiuronium bromide in the following ratio of components, wt.%: S-nonyl thiuronium bromide 0.001-5, solvent - the rest.
  • composition further comprises at least one component selected from the group comprising surfactants, compounds of sulfur, copper, iron, lime, compounds from the group of azoles, strobilurins, benzimidazoles, phenylamides, anilidopyrimidines, pyrimidinyl carbinols, dithianols, phosphanates, phthalamides, antibiotics, buffers, preservatives, antioxidants, wetting agents, antifoam agents, thickeners and humectants in an amount of 0.001-40 wt.%
  • the specified technical result is achieved in the method of biocidal treatment of plants due to the fact that it includes providing contact of the plant tissue or part thereof with said biocidal composition.
  • the provision of contacting the plant with the composition can be realized by: spraying the composition of the plant surface, soaking the plant roots in the composition, applying the composition to the surface of the seeds, injecting the composition into the plant stem, applying the composition to the soil.
  • the specified technical result is achieved in the method of biocidal processing of animals, due to the fact that it includes the application to the external tissues of the animal of said biocidal composition
  • S-nonyl thiuronium bromide does not contain cyclic, aromatic radicals, which eliminates the risks of the formation of compounds dangerous for plants and animals from the group of dioxins and dioxin-like compounds.
  • S-nonyl thiuronium bromide has not only bactericidal, but also fungicidal activity, which greatly expands the scope of its application.
  • the substance has a bactericidal and fungicidal effect against a wide range of harmful bacteria and fungi - pathogens of plants and animals, such as bacteria from the genus Xanthomonas, which cause great damage to agricultural plants.
  • S-nonyl thiuronium bromide has a significantly higher activity, since it ensures the death of harmful microorganisms in a concentration of from 0.0005 mg / ml.
  • S-nonyl thiuronium bromide has good solubility in water and other safe solvents. 5. S-nonyl thiuronium bromide has a low level of danger to plants and warm-blooded animals, including person. This, in turn, makes it possible to increase the safety level of the use of the claimed composition in biocidal treatment of plant or animal tissues at any concentration of the active component.
  • S-nonyl thiuronium bromide has the chemical formula CioH 23 N 2 SBr and the structural formula:
  • the substance is a white crystal with a melting point of 98-100 ° C, well soluble in water.
  • S-nonyl thiuronium bromide can be synthesized by heating a mixture of thiourea, nonyl bromide and ethanol.
  • the biocidal composition for treating plants and animals includes 0.001-20 wt.% S-nonyl thiuronium bromide and a solvent (the rest).
  • a solvent the rest.
  • the solvent used is preferably water. However, it is possible to use other solvents acceptable for contact with the tissues of plants and animals, for example, a solution of ethyl alcohol, etc.
  • the composition may also contain additional components, such as surfactants, sulfur compounds (ground and colloidal sulfur), copper (vitriol, copper chloroxide), iron (vitriol), lime, compounds from the group of azoles, strobilurins, benzimidazoles, phenylamides, anilidopyrimidines, pyrimidinyl carbinols, dithianols, phosphanates, phthalamides, antibiotics, buffers, preservatives, antioxidants, wetting agents, antifoam agents, thickeners, moisturizers.
  • surfactants sulfur compounds (ground and colloidal sulfur), copper (vitriol, copper chloroxide), iron (vitriol), lime
  • compounds from the group of azoles strobilurins, benzimidazoles, phenylamides, anilidopyrimidines, pyrimidinyl carbinols, dithianols, phosphanates, phthalamides, antibiotics, buffers, preservatives, antioxidants, wetting agents
  • a method for biocidal treatment of plants includes contacting the tissue of a part or the whole plant with said biocidal composition.
  • the treatment can be carried out by spraying the surface of the plant, soaking the roots, applying seeds to the surface, injecting into the stem or applying the composition to the soil.
  • a method of biocidal treatment of animals involves applying the composition to their skin.
  • concentration of s-nonyl thiuronium bromide for each case is selected individually depending on the purpose of treatment (treatment, prevention, protection, etc.) and the type of microorganism.
  • biocidal composition The following are specific examples of the use of the biocidal composition.
  • the fungicidal activity of the biocidal composition was analyzed with respect to a fungus of the genus Verticillium, a causative agent of diseases in cultivated and wild plants, such as vegetable crops: tomatoes, peppers and other nightshade, cotton, maple, and ornamental plants.
  • Tables 1 and 2 show the toxicity test data of the composition when analyzing the conidial progeny of colonies grown on a medium with different concentrations of S-nonyl thiuronium bromide, as well as a semi-lethal dose (LD50)
  • compositions and known fungicides are provided.
  • the fungicidal activity of the claimed composition was tested in relation to the fungus Peronoplasmopara (Pseudoperonospora) cubensis, the causative agent of the disease, powdery mildew in plants of the pumpkin family, including cucumber, squash, pumpkin and others.
  • Spraying of cucumber plantings was carried out during the growing season with an aqueous solution containing 0.01 wt.% S-nonyl tiuronium bromide to protect against the above disease. Spraying was carried out on an area of 25 hectares with a field sprayer with a flow rate of 400 l / ha.
  • Table 3 presents the results on the effectiveness of the composition.
  • the bactericidal activity of the composition against the bacterium Pseudomonas syringae pv was analyzed.
  • Spraying of cucumber plantings was carried out during the growing season with an aqueous solution containing 0.01 wt.% S-nonyl tiuronium bromide to protect against the above disease. Spraying was carried out on an area of 18 hectares with a field sprayer with a flow rate of 400 l / ha.
  • Trichophytosis also known as ringworm, is caused by the fungi Trichophyton, Microsporum and Epidermophyton and can affect domestic and farm animals, as well as humans.
  • the dog had severe symptoms of the disease - lesions of 15 - 20% of the body surface, manifested in the form of hair loss, redness and flaking of the skin.
  • the claimed composition has a high fungicidal and antibacterial activity and can be effectively and safely used to protect, prevent and treat plants and animals from fungal (fungal) and bacterial diseases.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

L'invention concerne des compositions biocides et des procédés de leur utilisation pour le traitement et la prévention et la protection de plantes et d'animaux à sang chaud (y.c. l'homme) contre les maladies causées par des champignons (agents fongiques) ou des bactéries. La composition biocide comprend des composants avec le rapport suivant, en % en masse : bromure de s-nonyl thiuronium 0,001-20, le reste étant le solvant. Le procédé de traitement de plantes par biocides consiste à assurer le contact du tissu de la plante ou d'une partie de celle-ci avec la composition biocide. Le procédé de traitement d'animaux par biocides consiste à assurer l'application de cette composition sur les tissus externes de l'animal. Le résultat technique consiste à améliorer les propriétés fongicides et antibactériennes de la composition, augmenter l'efficacité et la sécurité d'un traitement biocide pour les tissus des plantes et animaux et simplifier le procédé de production et d'application de la composition.
PCT/RU2017/050002 2016-07-22 2017-01-24 Composition biocide et procédés de traitement avec celle-ci de plantes et d'animaux WO2018016998A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2016130159 2016-07-22
RU2016130159A RU2629775C1 (ru) 2016-07-22 2016-07-22 Биоцидная композиция и способы обработки растений и животных с ее использованием

Publications (1)

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WO2018016998A1 true WO2018016998A1 (fr) 2018-01-25

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PCT/RU2017/050002 WO2018016998A1 (fr) 2016-07-22 2017-01-24 Composition biocide et procédés de traitement avec celle-ci de plantes et d'animaux

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RU (1) RU2629775C1 (fr)
WO (1) WO2018016998A1 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1551224A (en) * 1976-04-30 1979-08-30 Coalite Chem Prod Ltd Bactericidal detergent composition
SU668284A1 (ru) * 1977-03-04 1981-05-23 Предприятие П/Я Р-6225 Изотирониевые соли фосфоросодержащих симм- ТРиАзиНОВ,ОблАдАющиЕ гЕРбицидНОй АКТиВНОСТью
SU1005420A1 (ru) * 1981-05-19 2006-12-27 Краснодарский ордена Трудового Красного Знамени политехнический институт S-(5-Нитрофурфурил-2)-тиуроний бромид, обладающий антимикробной активностью

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2980578A (en) * 1955-06-24 1961-04-18 Armour & Company Of Delaware Method of combating plant-attacking fungus

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1551224A (en) * 1976-04-30 1979-08-30 Coalite Chem Prod Ltd Bactericidal detergent composition
SU668284A1 (ru) * 1977-03-04 1981-05-23 Предприятие П/Я Р-6225 Изотирониевые соли фосфоросодержащих симм- ТРиАзиНОВ,ОблАдАющиЕ гЕРбицидНОй АКТиВНОСТью
SU1005420A1 (ru) * 1981-05-19 2006-12-27 Краснодарский ордена Трудового Красного Знамени политехнический институт S-(5-Нитрофурфурил-2)-тиуроний бромид, обладающий антимикробной активностью

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