WO2018012352A1 - 歯科用ガラス、歯科用組成物 - Google Patents
歯科用ガラス、歯科用組成物 Download PDFInfo
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- WO2018012352A1 WO2018012352A1 PCT/JP2017/024481 JP2017024481W WO2018012352A1 WO 2018012352 A1 WO2018012352 A1 WO 2018012352A1 JP 2017024481 W JP2017024481 W JP 2017024481W WO 2018012352 A1 WO2018012352 A1 WO 2018012352A1
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- dental
- dental glass
- mass
- glass
- calcium
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/831—Preparations for artificial teeth, for filling teeth or for capping teeth comprising non-metallic elements or compounds thereof, e.g. carbon
- A61K6/833—Glass-ceramic composites
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/831—Preparations for artificial teeth, for filling teeth or for capping teeth comprising non-metallic elements or compounds thereof, e.g. carbon
- A61K6/838—Phosphorus compounds, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C3/00—Glass compositions
- C03C3/12—Silica-free oxide glass compositions
- C03C3/16—Silica-free oxide glass compositions containing phosphorus
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C3/00—Glass compositions
- C03C3/12—Silica-free oxide glass compositions
- C03C3/16—Silica-free oxide glass compositions containing phosphorus
- C03C3/19—Silica-free oxide glass compositions containing phosphorus containing boron
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C3/00—Glass compositions
- C03C3/12—Silica-free oxide glass compositions
- C03C3/23—Silica-free oxide glass compositions containing halogen and at least one oxide, e.g. oxide of boron
- C03C3/247—Silica-free oxide glass compositions containing halogen and at least one oxide, e.g. oxide of boron containing fluorine and phosphorus
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C4/00—Compositions for glass with special properties
- C03C4/0007—Compositions for glass with special properties for biologically-compatible glass
- C03C4/0021—Compositions for glass with special properties for biologically-compatible glass for dental use
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C4/00—Compositions for glass with special properties
- C03C4/0035—Compositions for glass with special properties for soluble glass for controlled release of a compound incorporated in said glass
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C2205/00—Compositions applicable for the manufacture of vitreous enamels or glazes
- C03C2205/06—Compositions applicable for the manufacture of vitreous enamels or glazes for dental use
Definitions
- the present invention relates to dental glass and a dental composition.
- Dental glass may be blended with dental compositions such as dental cement, dental composite resin, and dental adhesive. This is because, by adding dental glass to the dental composition, there is an effect of improving the strength and an effect of ions in the dental glass.
- ions in dental glass for example, aluminum ions can be cured by reacting with an acid solution (glass ionomer cement).
- fluoride ions are released into the oral cavity and taken into the tooth, so that the effect of strengthening the tooth and preventing dental caries is expected.
- Calcium ions and phosphate ions are also taken into the tooth structure, so that remineralization of the tooth structure and caries prevention effects are expected.
- dental glass containing calcium or phosphorus also referred to as a bioactive glass composition, bioactive glass, etc.
- blended is conventionally known.
- conventional dental glass does not necessarily have high calcium ion and phosphate ion release properties, and it cannot be said that dental remineralization and caries prevention effects are sufficient.
- This invention is made
- a dental glass containing phosphorus, sodium and / or potassium, and calcium In terms of oxide, Phosphorus (P 2 O 5 ) in an amount of 40% by mass to 70% by mass, Sodium and / or potassium (Na 2 O, K 2 O) in an amount of 20% by mass to 40% by mass, Containing 1% by mass or more and 20% by mass or less of calcium (CaO), A dental glass substantially free of silicon and aluminum is provided.
- dental glass that is excellent in calcium ion and phosphate ion release properties.
- the dental glass of the present embodiment can contain phosphorus, sodium and / or potassium, and calcium.
- phosphorus (P 2 O 5 ) is 40 mass% or more and 70 mass% or less
- sodium and / or potassium (Na 2 O, K 2 O) is 20 mass% or more and 40 mass% or less
- calcium ( CaO) can be contained in an amount of 1% by mass to 20% by mass.
- the inventors of the present invention are calcium ion and phosphate ion.
- dental glass containing phosphorus (P), one or more selected from sodium (Na) and potassium (K), and calcium (Ca) in a predetermined ratio The present invention was completed by finding that it has high solubility and can release a large amount of ions such as calcium ions and phosphate ions.
- the dental glass of this embodiment can contain phosphorus (P) in an amount of 40% by mass to 70% by mass in terms of oxide (P 2 O 5 ). This is because the solubility of dental glass in water can be increased by setting the P content to 40% by mass or more in terms of oxide.
- the content of P is preferably 70% by mass or less in terms of oxide. Phosphate ions released from dental glass have a remineralization and dental caries prevention effect on the tooth.
- the content of P in the dental glass of this embodiment is more preferably 53% by mass or more and 70% by mass or less in terms of oxide.
- the dental glass of the present embodiment may contain sodium (Na) and / or potassium (K) of the oxide equivalent (Na 2 O, K 2 O ) in 20 mass% or less than 40 wt%. This is because the solubility of dental glass in water can be increased by containing Na and / or K in an amount of 20% by mass or more in terms of oxide.
- the content of Na and / or K is preferably 40% by mass or less in terms of oxide.
- Sodium ions and / or potassium ions released from the dental glass have an effect of adjusting the pH value to be suitable for remineralization of tooth and prevention of dental caries.
- the content of Na and / or K in the dental glass of the present embodiment is more preferably 25% by mass or more and 40% by mass or less in terms of oxide.
- the dental glass of this embodiment can contain 1 mass% or more and 20 mass% or less of calcium (Ca) in terms of oxide (CaO). This is because the amount of calcium ions released from the dental glass can be sufficiently secured by setting the Ca content to 1% by mass or more in terms of oxide.
- the content of Ca is preferably 20% by mass or less in terms of oxide.
- Calcium ions released from dental glass have the effect of preventing remineralization of teeth and caries prevention.
- the Ca content in the dental glass of the present embodiment is more preferably 2% by mass or more and 15% by mass or less in terms of oxide.
- the dental glass of this embodiment does not contain silicon and aluminum substantially. This is because when silicon and / or aluminum is contained, the solubility of dental glass in water is lowered.
- substantially not contained here means that it is not actively added to the dental glass, and does not exclude, for example, mixing in impurities in the manufacturing process, that is, inevitable components. .
- the content of silicon and aluminum is less than 1% by mass in terms of oxide.
- the total content of silicon and aluminum is preferably less than 1% by mass in terms of oxide.
- the dental glass of this embodiment can also contain arbitrary components other than the above-mentioned components.
- the dental glass of the present embodiment can contain, for example, strontium (Sr) in an amount of 0 to 20% by mass in terms of oxide (SrO).
- Sr strontium
- SiO oxide
- X-ray contrast property can be imparted to the dental glass.
- the dental glass of this embodiment can also contain, for example, lanthanum (La) in an amount of 0 to 20% by mass in terms of oxide (La 2 O 3 ).
- La lanthanum
- X-ray contrast can be imparted to the dental glass.
- the dental glass of this embodiment can also contain, for example, boron (B) in an amount of 0 to 10% by mass in terms of oxide (B 2 O 3 ).
- B boron
- oxide B 2 O 3
- the dental glass of the present embodiment may contain, for example, zinc (Zn) in an oxide equivalent (ZnO) of 0 to 10% by mass.
- ZnO oxide equivalent
- antibacterial properties can be imparted to the dental glass.
- the dental glass of this embodiment can also contain, for example, silver (Ag) in an oxide equivalent (AgO) of 0 to 10% by mass.
- Ag silver
- AgO oxide equivalent
- the dental glass of the present embodiment can also contain, for example, fluorine (F) in a range of 0 to 20% by mass.
- F fluorine
- the dental caries can be given a caries prevention effect.
- the dental glass of the present embodiment does not substantially contain sulfur (S). This is because when the dental glass of this embodiment contains S, it may cause odor in the oral cavity.
- the term “substantially not containing” here means that it is not actively added to the dental glass as described above. For example, impurities in the manufacturing process, that is, those mixed as unavoidable components. It is not excluded.
- the dental glass of this embodiment preferably has a S content of less than 1% by mass.
- the dental glass of the present embodiment does not substantially contain iron (Fe). This is because when the dental glass of this embodiment contains Fe, it may cause tooth coloring in the oral cavity.
- the term “substantially not containing” here means that it is not actively added to the dental glass as described above. For example, impurities in the manufacturing process, that is, those mixed as unavoidable components. It is not excluded.
- the dental glass of this embodiment preferably has a Fe content of less than 1% by mass.
- the pH of the dental glass of this embodiment when dissolved in water is preferably 5 or more and 11 or less, and more preferably 6 or more and 10 or less. This is because if the pH is less than 5 or exceeds 11, it is not suitable for use in the oral cavity.
- the pH when the dental glass was dissolved in water was pulverized into a crushed glass having an average particle size of 10 ⁇ m, and the crushed glass was dispersed in distilled water to a concentration of 1% by mass, It can be set to pH after stirring at room temperature for 1 hour.
- the average particle diameter means the particle diameter at an integrated value of 50% in the particle size distribution obtained by the laser diffraction / scattering method, and has the same meaning in other parts of the present specification.
- the solubility of the dental glass of this embodiment in water is preferably 10% or more.
- evaluation of the solubility of dental glass in water can be carried out according to the following procedure.
- dental glass crushed to an average particle size of 10 ⁇ m is dispersed in distilled water to a concentration of 1% by mass (input dental glass mass), and stirred at room temperature for 1 hour. Subsequently, undissolved glass powder is collect
- the method for producing dental glass of the present embodiment described above is not particularly limited.
- the raw materials are weighed and mixed so as to have a predetermined dental glass composition, and heated to the melting point temperature or higher of the raw materials. And after making it fuse
- Various glass production methods such as a sol-gel method can also be used.
- the obtained dental glass can be pulverized so as to have a desired particle size according to the intended use. A preferred configuration example of the method for producing dental glass of the present embodiment will be described later.
- the dental glass of this embodiment P, Na and / or K, and Ca are contained so as to have predetermined contents, respectively, and silicon and aluminum are not substantially contained.
- the dental glass has a pH suitable for use in the oral cavity when dissolved in water, has high solubility in water, and has excellent ion release properties of calcium ions and phosphate ions. it can.
- the dental glass of the present embodiment can be used as a component of a dental composition, for example. That is, it can be set as the dental composition containing the dental glass of this embodiment.
- the dental composition is not particularly limited.
- a dental cement (conventional / resin reinforced glass ionomer cement, resin cement), a dental adhesive, a dental primer, a dental coating material, Examples thereof include a dental composite resin, a dental hard resin, a resin material for dental cutting, a temporary dental restoration material, a dental filler, and a dentifrice.
- the components other than the dental glass contained in the dental composition are not particularly limited, and various components can be contained according to the purpose of the dental composition.
- components other than dental glass that can be contained in the dental composition include fillers, (meth) acrylates, solvents, polymerization initiators, stabilizers, pigments, and the like.
- the filler examples include one or more selected from silica such as fumed silica, alumina, hydroxyapatite, titanium oxide, yttrium oxide, zirconia, fluoroaluminosilicate glass, barium glass, lanthanum glass, strontium glass, and quartz glass. It can be preferably used.
- the filler may be treated with a surface treatment agent such as a silane coupling agent as necessary.
- the above (meth) acrylate means various monomers, oligomers or prepolymers of acrylate or methacrylate, and can have one or more methacryloyloxy groups or acryloyloxy groups.
- the solvent for example, one or more selected from ethanol, propanol, methyl ethyl ketone, acetone and the like can be preferably used.
- the dental composition of this embodiment since the dental glass described above is contained, a dental composition having excellent ion release properties of calcium ions and phosphate ions can be obtained.
- Method of manufacturing dental glass Next, a configuration example of the dental glass manufacturing method of the present embodiment will be described.
- the dental glass described above can be produced by the method for producing dental glass of the present embodiment. For this reason, a part of the description already described will be omitted.
- dental glass can be produced by melting the raw material composition and then pulverizing it.
- the dental glass of the present embodiment can contain phosphorus, sodium and / or potassium, and calcium as described above.
- a raw material composition can contain the raw material corresponding to phosphorus, sodium and / or potassium, and calcium.
- a raw material corresponding to phosphorus For example, 1 or more types selected from phosphoric acid, sodium phosphate, potassium phosphate, calcium phosphate, strontium phosphate, sodium dihydrogen phosphate etc. can be used preferably. . Two or more selected from the above compound group may be used in combination.
- a raw material corresponding to sodium For example, 1 or more types selected from sodium phosphate, sodium dihydrogen phosphate, sodium carbonate, sodium hydrogencarbonate, sodium fluoride etc. can be used preferably. Two or more selected from the above compound group may be used in combination.
- potassium phosphate 1 or more types selected from potassium phosphate, potassium fluoride, potassium carbonate, potassium hydrogencarbonate, dipotassium hydrogenphosphate etc. can be used preferably. Two or more selected from the above compound group may be used in combination.
- a raw material corresponding to calcium For example, 1 or more types selected from calcium fluoride, calcium phosphate, calcium carbonate, calcium hydroxide etc. can be used preferably. Two or more selected from the above compound group may be used in combination.
- the dental glass of the present embodiment can contain any component other than the above-described components.
- it can also contain one or more selected from strontium, lanthanum, boron, zinc, silver, fluorine and the like.
- a raw material composition can contain the raw material corresponding to an arbitrary component.
- the raw material corresponding to strontium is not particularly limited, but for example, one or more selected from strontium fluoride, strontium hydroxide, strontium carbonate, strontium oxide, strontium phosphate and the like can be preferably used. Two or more selected from the above compound group may be used in combination.
- the raw material corresponding to lanthanum is not particularly limited, but for example, one or more selected from lanthanum fluoride, lanthanum oxide and the like can be preferably used. Two or more selected from the above compound group may be used in combination.
- boron oxide 1 or more types selected from boron oxide, borax, boron phosphate, etc. can be used preferably. Two or more selected from the above compound group may be used in combination.
- a raw material corresponding to zinc For example, 1 or more types selected from zinc oxide, zinc fluoride, etc. can be used preferably. Two or more selected from the above compound group may be used in combination.
- a raw material corresponding to silver For example, 1 or more types selected from silver oxide, silver nitrate, silver fluoride, etc. can be used preferably. Two or more selected from the above compound group may be used in combination.
- a raw material corresponding to a fluorine For example, 1 or more types selected from calcium fluoride, strontium fluoride, sodium fluoride etc. can be used preferably. Two or more selected from the above compound group may be used in combination.
- Each raw material in the raw material composition may be blended so as to correspond to the composition of the dental glass.
- each raw material can be weighed and mixed according to the composition of the dental glass to prepare the raw material composition (raw material composition Preparation step).
- the obtained raw material composition is placed in, for example, a crucible, heated and dissolved at a temperature corresponding to the melting point of the raw material to be contained, for example, 700 ° C. or higher and 1500 ° C. or lower, and then cooled (heating, Cooling step).
- the cooling rate at the time of cooling is not particularly limited, for example, it is preferable to quench by various quenching means such as the above-described twin roll method or a method in which a melt is poured onto a metal plate and pressed.
- dental glass After cooling and solidification, dental glass can be produced by grinding to a desired particle size (grinding step).
- the method for producing dental glass of the present embodiment can further include an optional step in addition to the above-described steps. For example, classification or the like can be performed so that the particle size distribution of the obtained dental glass becomes a desired distribution.
- a dental glass raw material was mixed to prepare a raw material composition. After heating and melting the raw material composition, dental glass was prepared by rapidly cooling to room temperature. . Then, the state of the prepared dental glass was confirmed visually, and when vitrification was confirmed, it was evaluated as ⁇ , and when not vitrified, it was evaluated as x. In addition, since dental glass has not been produced when it is not vitrified, subsequent evaluation was not performed. (Solubility in water) The produced dental glass was crushed to obtain a crushed glass having an average particle size of 10 ⁇ m.
- the pulverized glass is dispersed in distilled water so as to have a concentration of 1% by mass (input dental glass mass), and stirred at room temperature for 1 hour. And after undissolved glass powder is collect
- Example 1 A dental glass was prepared and evaluated in the same manner as in Example 1 except that the raw materials were weighed and mixed so that the composition of the dental glass became the composition shown in Table 1 for each example. It was.
- Comparative Example 2 and Comparative Examples 5 to 9 had a solubility in water of less than 10%, and it was confirmed that they did not show sufficient solubility in water. Therefore, it was confirmed that the dental glass was inferior in ion release properties such as calcium ions and phosphate ions.
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Abstract
Description
酸化物換算で、
リン(P2O5)を40質量%以上70質量%以下、
ナトリウム及び/又はカリウム(Na2O、K2O)を20質量%以上40質量%以下、
カルシウム(CaO)を1質量%以上20質量%以下含有し、
ケイ素及びアルミニウムを実質的に含有しない歯科用ガラスを提供する。
[歯科用ガラス]
本実施形態では歯科用ガラスの一構成例について説明する。
また、ケイ素及びアルミニウムを実質的に含有しないことが好ましい。
=[(投入歯科用ガラス質量)-(未溶解歯科用ガラス質量)]/(投入歯科用ガラス質量)×100・・・式(1)
以上に説明した本実施形態の歯科用ガラスの製造方法は特に限定されるものではないが、例えば、所定の歯科用ガラスの組成となるように原料を秤量混合し、原料の融点温度以上に加熱し、溶融させて均質化させた後、溶融物を水に投入する方法や、双ロール法等により急冷することで製造することができる。また、ゾル-ゲル法等の各種ガラスの製造方法を用いることもできる。なお、得られた歯科用ガラスには、使用する用途に応じて、所望の粒径となるように粉砕処理を施すこともできる。本実施形態の歯科用ガラスの製造方法の好適な構成例については後述する。
[歯科用ガラスの製造方法]
次に、本実施形態の歯科用ガラスの製造方法の一構成例について説明する。なお、本実施形態の歯科用ガラスの製造方法により、既述の歯科用ガラスを製造することができる。このため、既に説明した事項については、一部説明を省略する。
(ガラス化)
以下の各実施例、比較例では、歯科用ガラスの原料を混合して原料組成物を調製し、該原料組成物を加熱、溶融させた後、室温まで急冷することで歯科用ガラスを調製した。そこで、調製した歯科用ガラスの状態を目視で確認し、ガラス化が確認できた場合には〇、ガラス化していない場合には×と評価した。なお、ガラス化していない場合には、歯科用ガラスが作製できていないことになるため、以後の評価は実施していない。
(水への溶解性)
作製した歯科用ガラスを粉砕し、平均粒径10μmの粉砕ガラスとした。次いで、該粉砕ガラスを蒸留水中に1質量%の濃度となるように分散させ(投入歯科用ガラス質量)、室温下で1時間撹拌する。そして、未溶解ガラス粉をろ紙で回収し、乾燥させた後、乾燥後の未溶解歯科用ガラスの質量(未溶解歯科用ガラス質量)を測定し、以下の式(1)により歯科用ガラスの水への溶解性を算出した。
=[(投入歯科用ガラス質量)-(未溶解歯科用ガラス質量)]/(投入歯科用ガラス質量)×100・・・式(1)
(水に溶解後のpH)
作製した歯科用ガラスを粉砕し、平均粒径10μmの粉砕ガラスとした。次いで、該粉砕ガラスを蒸留水中に1質量%の濃度となるように分散させ、室温下で1時間撹拌した後のpHを測定し、水に溶解後のpHとした。
[実施例1]
表1に示す組成になるように、原料としてリン酸、リン酸カルシウム、及び炭酸ナトリウムを秤量混合した。そして、得られた混合物を白金るつぼに入れ、大気雰囲気下、1100℃で加熱し、溶解させた後、ステンレス製の板の上に流し出し、アイロンでプレスすることで急冷し、歯科用ガラスを製造した。
[実施例2~実施例8]
歯科用ガラスの組成が、各実施例について表1に示した組成になるように原料を秤量、混合した点を除いては、実施例1と同様にして歯科用ガラスを調製し、評価を行った。
[比較例1~比較例9]
歯科用ガラスの組成が、各比較例について表1に示した組成になるように原料を秤量、混合した点を除いては、実施例1と同様にして歯科用ガラスを調製し、評価を行った。
Claims (2)
- リンと、ナトリウム及び/又はカリウムと、カルシウムとを含有する歯科用ガラスであって、
酸化物換算で、
リン(P2O5)を40質量%以上70質量%以下、
ナトリウム及び/又はカリウム(Na2O、K2O)を20質量%以上40質量%以下、
カルシウム(CaO)を1質量%以上20質量%以下含有し、
ケイ素及びアルミニウムを実質的に含有しない歯科用ガラス。 - 請求項1に記載の歯科用ガラスを含有する歯科用組成物。
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP17827482.5A EP3485868B1 (en) | 2016-07-15 | 2017-07-04 | Dental glass and dental composition |
BR112019000329-0A BR112019000329B1 (pt) | 2016-07-15 | 2017-07-04 | Vidro odontológico e composição odontológica |
ES17827482T ES2927530T3 (es) | 2016-07-15 | 2017-07-04 | Vidrio dental y composición dental |
JP2018527530A JP6859348B2 (ja) | 2016-07-15 | 2017-07-04 | 歯科用ガラス、歯科用組成物 |
PL17827482.5T PL3485868T3 (pl) | 2016-07-15 | 2017-07-04 | Szkło dentystyczne i kompozycja dentystyczna |
US16/315,781 US10865133B2 (en) | 2016-07-15 | 2017-07-04 | Dental glass and dental composition |
US16/951,286 US20210070651A1 (en) | 2016-07-15 | 2020-11-18 | Dental glass and dental composition |
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JP2016-140440 | 2016-07-15 |
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US16/315,781 A-371-Of-International US10865133B2 (en) | 2016-07-15 | 2017-07-04 | Dental glass and dental composition |
US16/951,286 Continuation US20210070651A1 (en) | 2016-07-15 | 2020-11-18 | Dental glass and dental composition |
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US (2) | US10865133B2 (ja) |
EP (1) | EP3485868B1 (ja) |
JP (2) | JP6859348B2 (ja) |
BR (1) | BR112019000329B1 (ja) |
ES (1) | ES2927530T3 (ja) |
PL (1) | PL3485868T3 (ja) |
WO (1) | WO2018012352A1 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2024123076A1 (ko) * | 2022-12-08 | 2024-06-13 | 연세대학교 산학협력단 | 항균 효과를 가지는 치과용 복합레진 조성물 및 이의 제조방법 |
JP7509640B2 (ja) | 2020-09-30 | 2024-07-02 | 株式会社ジーシー | 歯科用組成物 |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017168836A1 (ja) * | 2016-03-28 | 2017-10-05 | 株式会社ジーシー | 歯科用ガラス粉末 |
WO2018003419A1 (ja) | 2016-06-30 | 2018-01-04 | 株式会社ジーシー | 歯科用処置材、及び歯科用処置材キット |
EP3485868B1 (en) * | 2016-07-15 | 2022-09-07 | GC Corporation | Dental glass and dental composition |
EP3883896A1 (en) * | 2018-11-20 | 2021-09-29 | Corning Incorporated | Bioactive phosphate glasses |
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- 2017-07-04 JP JP2018527530A patent/JP6859348B2/ja active Active
- 2017-07-04 BR BR112019000329-0A patent/BR112019000329B1/pt active IP Right Grant
- 2017-07-04 WO PCT/JP2017/024481 patent/WO2018012352A1/ja unknown
- 2017-07-04 ES ES17827482T patent/ES2927530T3/es active Active
- 2017-07-04 US US16/315,781 patent/US10865133B2/en active Active
- 2017-07-04 PL PL17827482.5T patent/PL3485868T3/pl unknown
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2020
- 2020-06-23 JP JP2020107813A patent/JP2020152730A/ja not_active Withdrawn
- 2020-11-18 US US16/951,286 patent/US20210070651A1/en not_active Abandoned
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Cited By (2)
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---|---|---|---|---|
JP7509640B2 (ja) | 2020-09-30 | 2024-07-02 | 株式会社ジーシー | 歯科用組成物 |
WO2024123076A1 (ko) * | 2022-12-08 | 2024-06-13 | 연세대학교 산학협력단 | 항균 효과를 가지는 치과용 복합레진 조성물 및 이의 제조방법 |
Also Published As
Publication number | Publication date |
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JP6859348B2 (ja) | 2021-04-14 |
JP2020152730A (ja) | 2020-09-24 |
PL3485868T3 (pl) | 2022-12-12 |
US10865133B2 (en) | 2020-12-15 |
EP3485868A4 (en) | 2020-03-04 |
EP3485868A1 (en) | 2019-05-22 |
ES2927530T3 (es) | 2022-11-08 |
EP3485868B1 (en) | 2022-09-07 |
US20190151204A1 (en) | 2019-05-23 |
BR112019000329B1 (pt) | 2022-08-02 |
BR112019000329A2 (pt) | 2019-04-24 |
US20210070651A1 (en) | 2021-03-11 |
JPWO2018012352A1 (ja) | 2019-04-25 |
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