WO2017219837A1 - 皮肤表面用驱蚊喷剂 - Google Patents

皮肤表面用驱蚊喷剂 Download PDF

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Publication number
WO2017219837A1
WO2017219837A1 PCT/CN2017/086765 CN2017086765W WO2017219837A1 WO 2017219837 A1 WO2017219837 A1 WO 2017219837A1 CN 2017086765 W CN2017086765 W CN 2017086765W WO 2017219837 A1 WO2017219837 A1 WO 2017219837A1
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Prior art keywords
parts
component
mixture
skin surface
water
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PCT/CN2017/086765
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English (en)
French (fr)
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吴克
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江苏奇力康皮肤药业有限公司
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Publication of WO2017219837A1 publication Critical patent/WO2017219837A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55—Phosphorus compounds
    • A61K8/553—Phospholipids, e.g. lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/678—Tocopherol, i.e. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18

Definitions

  • the invention relates to a mosquito repellent spray. More specifically, the present invention relates to an insect repellent spray for skin surfaces.
  • Mosquito belonging to the insect family Diptera, is a small flying insect with a sucking mouthpart. Usually the female uses blood as food, while the male uses the juice of the plant. Blood-sucking female mosquitoes are intermediate hosts for various pathogens such as dengue fever, malaria, yellow fever, filariasis, and Japanese encephalitis. On the earth, except for Antarctica, there are mosquitoes in all other continents.
  • mosquitoes like to bite people with weak acidity. After being bitten by a mosquito, the human skin usually has redness, itching, pain and other symptoms. People with poor skin texture may have more serious symptoms, such as: local itching; small red papules appear; scars appear, ie smooth, bulging Reddened skin or hard swelling.
  • Summer is the best time for breeding of blood-sucking animals such as mosquitoes. It has a strong reproductive and reproductive capacity in summer, and in summer, people have more outdoor activities, and most of them are thin, especially the limbs are often exposed. It is common to be bitten by mosquitoes in summer. ,very common. Anti-mosquito bites appear to be necessary.
  • mosquito repellent drugs sold on the market are made of chemical components, which not only have certain side effects, but also cause pollution to the environment. When they reach the effect of killing mosquitoes, they also pose harm to people, especially The human respiratory tract constitutes an adverse effect. The better the insecticidal effect of this chemical, the more side effects it has, and it is not easy to use it in large quantities.
  • toilet water although it consists only of traditional Chinese medicine and spices, it has a certain effect on mosquito repellent, but its volatility is strong, its persistence is short, and the skin permeability after use is poor, so it needs to be cleaned in time.
  • the invention of Chinese Patent No. CN102018004A discloses a multi-effect mosquito repellent syrup which is composed of a mixture of aerobic amine, citronella oil, amine leaf oil, tea tree oil, pyrethrum vinegar and Litsea cubeba oil.
  • the invention has long anti-mosquito action and has the functions of sterilization, disinfection and air purification, but has poor durability and needs to be applied multiple times.
  • the invention of Chinese Patent No. CN102579288A discloses a direct-acting natural plant essential oil composition for mosquito repellent.
  • the invention can effectively repel mosquitoes, but there are Inefficient, and long-term use of ethanol is easy to cause damage to the skin.
  • CN101233864 discloses a mosquito repellent essential oil composition and a mosquito repellent method, From clove oil, Litsea cubeba oil, leaf oil, pure seed linden leaf oil, thyme oil, citronella oil, geranium oil, lavender oil, wintergreen oil, peppermint oil, cinnamon oil, cedar oil, white orchid leaf oil, It is composed of musk oil, rose oil and tea tree oil.
  • the technical source of the technical solution is complicated, the cost is high, and the total efficiency of mosquito repellent is not as significant as the present invention.
  • anti-mosquito agents are used as a single cosmetic to protect the surface of the skin from mosquitoes.
  • the anti-mosquito agents used in the form of sprays on the skin surface are often very short in efficacy and fast in evaporation.
  • Still another object of the present invention is to provide an insect repellent spray for skin surface, which uses a functional anti-mosquito component and an active component which can enhance the activity of the anti-mosquito component, and has good compatibility with the skin.
  • the essential oil is used as the main component, and the prepared mosquito repellent spray can be better adsorbed on the surface of the skin by a special method to prolong its durability.
  • an insect repellent spray for skin surfaces comprising the following ingredients (by mass fraction):
  • Ingredient B Ai Ye essential oil
  • Ingredient C lecithin, 2 to 5 parts; ephedrine, 0.001 to 0.1 parts; anthraquinone extract, 0.005 to 0.1 parts; natural squalane, 2 to 10 parts; VE or VE derivative, 0.5 to 5 parts;
  • Ingredient D glycerin, 5 to 15 parts; the balance is water;
  • component A and component B are uniformly mixed in a ratio of 1:2 to 1:1, component C and component D are uniformly mixed, and then a mixture of component A and component B is added; mixture of component A and component B: component C and component The mixture of D is from 9:41 to 3:7.
  • the skin surface is provided with an insect repellent spray, wherein the following ingredients are included (by mass fraction):
  • Ephedrine 0.001 parts
  • the balance is water.
  • the skin surface is provided with an insect repellent spray, wherein the following ingredients are included (by mass fraction):
  • Ephedrine 0.1 part
  • the balance is water.
  • the skin surface is provided with an insect repellent spray, wherein the following ingredients are included (by mass fraction):
  • Citronellol 5 parts
  • Ephedrine 0.1 part
  • the balance is water.
  • the skin surface is an insect repellent spray, wherein the VE derivative is VE acetate.
  • the skin surface is sprayed with an insect repellent spray, wherein the mixing of the component A and the component B is specifically: distilling water to form a steam using distilled water, and continuously continuing to pass high temperature steam within 7 to 10 days.
  • the linalool, citronellol and geraniol mixed with steam are mixed to form the component A, and the component A and the The component B is uniformly mixed.
  • the skin surface is sprayed with an insect repellent spray, wherein the mixing of the component C and the component D is specifically: taking a certain amount of VE or VE derivative, and immersing it in a small amount of glycerin 2 ⁇ 5 days, add ephedrine to it; add a certain amount of lecithin, medlar extract and natural squalane to glycerin, soak for 2 to 5 days, shake 3 to 6 times a day, each time 5 to 10 minutes; The glycerol mixture containing VE or VE derivative added with ephedrine is quickly added to the glycerin mixture containing lecithin, medlar extract and natural squalane, and an appropriate amount of water is added thereto, and shaken for 10 to 30 minutes at a temperature of 20-40 ° C. A mixture of the component C and the component D is obtained.
  • the skin surface is an insect repellent spray, wherein a mixture of the prepared component A and the component B and the mixture of the component C and the component D are remixed under pressure. Heating from 0.5 to 1.33 kPa to 100 to 120 ° C, for 3 to 10 minutes, cooling to 60 to 70 ° C, filtering the mixture to remove slag, and then autoclaving, which is a spray to prevent mosquito bites .
  • the skin surface is provided with an insect repellent spray, wherein the mixture of the component A and the component B further comprises saffron.
  • the skin surface is sprayed with an insect repellent spray, wherein 0.2 to 1 g of the saffron is soaked in 200 to 600 mL of water, soaked for 20 to 40 minutes, and then boiled to 60 to 200 mL of water.
  • the upper layer of mash was added to the mixture of the component A and the component B in a mass ratio of 1:6 to 1:10.
  • linalool, citronellol and geraniol as main functional components for mosquito control, distilling water to distillate water to form steam, using steam to fume linalool, citronellol and geraniol to make linden Alcohol, citronellol and geraniol are combined with the active ingredients of the leaves, so that they are suitable for direct contact with human skin;
  • the linalool, citronellol and geraniol, which have been fumigated by Aiye steam, are mixed in a certain proportion, which can not only achieve mosquito repellent and mosquito repellent effect, but also suit human skin use;
  • the essential oil of Aiye leaves is mixed with linalool, citronellol and geraniol.
  • the molecules of Aiye oil are combined with the molecules of linalool, citronellol and geraniol, respectively, and then the compatibility between the molecules of Aiye oil is passed. To fully integrate the four components to enhance their anti-mosquito effect;
  • lecithin, medlar extract and natural squalane can not only enhance the skin's self-defense ability, but also enhance the skin's adaptability to the mixed ingredients of eucalyptus essential oil, linalool, citronellol and geraniol, enhance functional ingredients in Adsorption of the skin surface, so that the spray has a long-lasting mosquito repellent effect;
  • the VE or VE derivative to which ephedrine is added is an active ingredient which activates the activity of the mixture of the component C and the component D for the mixture of the component A and the component B, so that the functional component A is coated with the components B, C and D.
  • the oily film retains its long-lasting functionality and delays its release, thereby enhancing the durability of the spray and its adsorption on the skin surface;
  • the spray added with saffron can be sprayed on the affected part of the mosquito bite, or can be used routinely, and the quantitative saffron supernatant is added to the mixture of the component A and the component B, so that The saffron is adsorbed on the surface of the essential oil molecules, thereby improving the comfort of the skin.
  • the present invention provides an insect repellent spray for skin surface comprising the following components (by mass fraction):
  • Ingredient B Ai Ye essential oil
  • Ingredient C lecithin, 2 to 5 parts; ephedrine, 0.001 to 0.1 parts; anthraquinone extract, 0.005 to 0.1 parts; natural squalane, 2 to 10 parts; VE or VE derivative, 0.5 to 5 parts;
  • Ingredient D glycerin, 5 to 15 parts; the balance is water;
  • component A and component B are uniformly mixed in a ratio of 1:2 to 1:1, component C and component D are uniformly mixed, and then a mixture of component A and component B is added; mixture of component A and component B: component C and component The mixture of D is from 9:41 to 3:7.
  • VE derivative is VE acetate.
  • the mixing of the component A and the component B is specifically: distilling water into a steam using distilled water, and continuously transferring the high-temperature steam into a container containing a certain amount of linalool, citronellol and geraniol within 7 to 10 days. Inside, the linalool, citronellol, and geraniol mixed with steam are mixed to form the component A, and the component A and the component B are uniformly mixed.
  • the mixing of the component C and the component D is specifically: taking a certain amount of VE or VE derivative, soaking it in a small amount of glycerin for 2 to 5 days, adding ephedrine thereto; and adding a certain amount of lecithin and strontium
  • the extract and natural squalane are sequentially added to glycerin, soaked for 2 to 5 days, shaken 3 to 6 times a day for 5 to 10 minutes each time; the glycerin mixture containing VE or VE derivative added to ephedrine is quickly added to A mixture of glycerol containing lecithin, medlar extract and natural squalane is added with an appropriate amount of water, shaken for 10 to 30 minutes, and the temperature is 20-40 ° C to obtain a mixture of the component C and the component D.
  • Ephedrine 0.001 parts
  • the balance is water.
  • the mixing of the component A and the component B is specifically: distilling water into a steam using distilled water, and continuously transferring the high-temperature steam into a container containing a certain amount of linalool, citronellol and geraniol within 7 days.
  • the linalool, citronellol, and geraniol mixed with steam are mixed to form the component A, and the component A and the component B are uniformly mixed.
  • the mixing of the component C and the component D is specifically: taking a certain amount of VE or VE derivative, immersing it in a small amount of glycerin for 2 days, adding ephedrine thereto; and adding a certain amount of lecithin and strontium extract And natural squalane is sequentially added to glycerin, soaked for 2 days, shaken 3 times a day for 5 minutes each time; the glycerin mixture containing VE or VE derivative added with ephedrine is quickly added to the lecithin-containing, sputum extract and To the glycerin mixture of natural squalane, an appropriate amount of water was added, and the mixture was shaken for 10 minutes at a temperature of 20 ° C to obtain a mixture of the component C and the component D.
  • Ephedrine 0.1 part
  • the balance is water.
  • the mixing of the component A and the component B is specifically: distilling steam to form a steam using distilled water, and continuously transferring the high-temperature steam into a container containing a certain amount of linalool, citronellol and geraniol within 8 days. Will be mixed with steam The sterol, citronellol, and geraniol are mixed to form the component A, and the component A and the component B are uniformly mixed.
  • the mixing of the component C and the component D is specifically: taking a certain amount of VE or VE derivative, immersing it in a small amount of glycerin for 3 days, adding ephedrine thereto; and adding a certain amount of lecithin and strontium extract And natural squalane is sequentially added to glycerin, soaked for 3 days, shaken 5 times a day for 8 minutes each time; the glycerol mixture containing VE or VE derivative added with ephedrine is quickly added to the lecithin-containing extract and the extract To the glycerin mixture of natural squalane, an appropriate amount of water was added, and the mixture was shaken for 20 minutes at a temperature of 30 ° C to obtain a mixture of the component C and the component D.
  • Citronellol 5 parts
  • Ephedrine 0.1 part
  • the balance is water.
  • the mixing of the component A and the component B is specifically: distilling water into a steam using distilled water, and continuously transferring the high-temperature steam into a container containing a certain amount of linalool, citronellol and geraniol within 10 days.
  • the linalool, citronellol, and geraniol mixed with steam are mixed to form the component A, and the component A and the component B are uniformly mixed.
  • the mixing of the component C and the component D is specifically: taking a certain amount of VE or VE derivative, immersing it in a small amount of glycerin for 5 days, adding ephedrine thereto; and adding a certain amount of lecithin and strontium extract And natural squalane is added to glycerin in turn, soaked for 5 days, shaken 6 times a day for 10 minutes each time; VE or VE derived with ephedrine added
  • the glycerin mixture of the mixture was quickly added to a mixture of glycerol containing lecithin, strontium extract and natural squalane, and an appropriate amount of water was added thereto, and the mixture was shaken for 30 minutes at a temperature of 40 ° C to obtain a mixture of the component C and the component D.
  • Ephedrine 0.001 parts
  • the balance is water
  • the mixing of the component A and the component B is specifically: distilling steam to form a steam by using distilled water, and continuously transferring the high-temperature steam into a container containing a certain amount of linalool, citronellol and geraniol within 8 days. Inside, the linalool, citronellol, and geraniol mixed with steam are mixed to form the component A, and the component A and the component B are uniformly mixed.
  • the mixing of the component C and the component D is specifically: taking a certain amount of VE or VE derivative, immersing it in a small amount of glycerin for 3 days, adding ephedrine thereto; and adding a certain amount of lecithin and strontium extract And natural squalane is added to glycerin in turn, soaked for 3 days, shaken 4 times a day for 5 minutes each time; the mixture of glycerin containing VE or VE derivative added with ephedrine is quickly added to the lecithin-containing extract and the extract Add glycerin mixture of natural squalane Water was weighed, shaken for 15 minutes, and the temperature was 20 ° C to obtain a mixture of the component C and the component D.
  • Ephedrine 0.1 part
  • the balance is water.
  • the mixing of the component A and the component B is specifically: distilling steam to form a steam using distilled water, and continuously transferring the high-temperature steam into a container containing a certain amount of linalool, citronellol and geraniol within 9 days. Inside, the linalool, citronellol, and geraniol mixed with steam are mixed to form the component A, and the component A and the component B are uniformly mixed.
  • the mixing of the component C and the component D is specifically: taking a certain amount of VE or VE derivative, immersing it in a small amount of glycerin for 4 days, adding ephedrine thereto; and adding a certain amount of lecithin and strontium extract And natural squalane is sequentially added to glycerin, soaked for 4 days, shaken 4 times a day for 6 minutes each time; the mixture of glycerol containing VE or VE derivative added with ephedrine is quickly added to the lecithin-containing extract and the extract To the glycerin mixture of natural squalane, an appropriate amount of water was added, and the mixture was shaken for 22 minutes at a temperature of 25 ° C to obtain a mixture of the component C and the component D.
  • Example 3 Comparing the sprays prepared in Example 1, Example 2 and Example 3 with commercially available mosquito sprays, the spray durability in Example 3 was found>Example 2>Example 1>Commercial products, The effect of Example 3 was best when it was wiped on the surface of human skin.
  • Example 4 Comparing the sprays prepared in Example 3, Example 4 and Example 5, it was found that the anti-mosquito spray durability of Example 3>Example 4>Example 5, and the comfort of Example 5 was the best.

Abstract

一种皮肤表面用驱蚊喷剂，其采用跟皮肤相容性较好的精油作为主成分，同时添加了具有功能性作用的防蚊成分及可提升防蚊成分活性的活性组分，使制得的喷剂可较好的吸附于皮肤表面，且具有防蚊功效。

Description

皮肤表面用驱蚊喷剂 技术领域
本发明涉及一种驱蚊喷剂。更具体地说，本发明涉及一种皮肤表面用驱蚊喷剂。
背景技术
蚊子，属于昆虫纲双翅目蚊科，是一种具有刺吸式口器的纤小飞虫。通常雌性以血液作为食物，而雄性则吸食植物的汁液。吸血的雌蚊是登革热、疟疾、黄热病、丝虫病、日本脑炎等多种病原体的中间寄主。而地球上除南极洲外，其他各大洲皆有蚊子的分布。
一般来讲，蚊子喜欢叮咬体质呈弱酸性的人。被蚊子叮咬后，人体皮肤通常会出现红肿、痒、痛等症状，皮肤肤质不好的人会出现更严重症状，如：局部瘙痒；出现小红丘疹；出现叮痕，即平滑、凸起、发红的皮肤或者硬肿等。
夏季是蚊子这类吸血动物繁育的最佳时机，其在夏天生育繁殖能力特别强，而夏天由于人们户外活动较多，且多都衣着单薄，特别是四肢往往外露，夏季被蚊虫叮咬就很普遍、很常见。防蚊虫叮咬显得很有必要。
现在市场上销售的各类驱蚊虫药物，多采用化学成分制成，不仅具有一定的副作用，而且对环境还造成污染，其在达到杀蚊虫效果的同时，也构成对人的伤害，尤其是对人的呼吸道构成不良影响。这种化学药剂杀蚊虫效果越好，其副作用也就越大，因此不易大量使用。像经常使用的花露水，虽然仅由中药和香料构成，对驱蚊虫有一定的效果，但是其挥发性强，持续性短暂，使用后皮肤透气性差，需要及时清洗。
中国专利号为CN102018004A的发明公开了一种多效驱蚊药水，由避蚊胺、香茅油、胺叶油、茶树油、除虫菊醋、山苍子油六组分药料混合而成，本发明驱蚊时间长，同时具有杀菌、消毒、净化空气的作用，但其持久性差，需要多次涂抹；中国专利号为CN102579288A的发明公开了一种可直接作用的驱蚊虫用天然植物精油组合物，由薰衣草油、柠檬草油、罗勒油、洋甘菊油、薄荷油、尤加利油、茶树油、香茅草油、百里香油、甘油、乙醇组成，该发明能有效起到驱蚊作用，但有效率不高，而且长期使用乙醇易对皮肤造成伤害。中国专利号为CN101233864的发明公开了一种驱蚊精油组合物及驱蚊方法， 由丁香油、山苍子油、按叶油、纯种芳樟叶油、百里香油、香茅油、香叶油、薰衣草油、冬青油、薄荷素油、肉桂油、柏木油、白兰叶油、芸香油、玫瑰油、茶树油组成，该技术方案原料来源复杂，成本高，驱蚊总效率不及本发明显著。
现有防蚊剂多是作为单一化妆品涂覆于皮肤表面起防蚊作用，以喷剂形式使用于皮肤表面的防蚊剂往往药效时间非常短，挥发快。
发明内容
本发明的一个目的是解决至少上述问题，并提供至少后面将说明的优点。
本发明还有一个目的是提供一种皮肤表面用驱蚊喷剂，其采用具有功能性作用的防蚊成分及可提升防蚊成分活性的活性组分，同时添加了跟皮肤相容性较好的精油作为主成分，采用特殊制法使制得的驱蚊喷剂可较好的吸附于皮肤表面，延长其持久性。
为了实现本发明的这些目的和其它优点，提供了一种皮肤表面用驱蚊喷剂，其包含以下成分(按质量分数计)：
成分A：芳樟醇：香茅醇：香叶醇为1:1:1～1:4:1；
成分B：艾叶精油；
成分C：卵磷脂，2～5份；麻黄碱，0.001～0.1份；茯苓提取物，0.005～0.1份；天然角鲨烷，2～10份；VE或VE衍生物，0.5～5份；
成分D：甘油，5～15份；余量为水；
其中成分A与成分B以1:2～1:1比例混合均匀，成分C与成分D混合均匀后，再将成分A与成分B的混合物加入；成分A与成分B的混合物：成分C与成分D的混合物为9:41～3:7。
优选的是，所述的皮肤表面用驱蚊喷剂，其中，包含以下成分(按质量分数计)：
芳樟醇，2份；
香茅醇，2份；
香叶醇，2份；
艾叶精油，12份；
卵磷脂，2份；
茯苓提取物，0.005份；
天然角鲨烷，2份；
VE或VE衍生物，0.5份；
麻黄碱，0.001份；
甘油，5份；
余量为水。
优选的是，所述的皮肤表面用驱蚊喷剂，其中，包含以下成分(按质量分数计)：
芳樟醇，2份；
香茅醇，8份；
香叶醇，2份；
艾叶精油，12份；
卵磷脂，5份；
茯苓提取物，0.1份；
天然角鲨烷，10份；
VE或VE衍生物，5份；
麻黄碱，0.1份；
甘油，15份；
余量为水。
优选的是，所述的皮肤表面用驱蚊喷剂，其中，包含以下成分(按质量分数计)：
芳樟醇，5份；
香茅醇，5份；
香叶醇，5份；
艾叶精油，15份；
卵磷脂，3份；
茯苓提取物，0.05份；
天然角鲨烷，8份；
VE或VE衍生物，2份；
麻黄碱，0.1份；
甘油，10份；
余量为水。
优选的是，所述的皮肤表面用驱蚊喷剂，其中，所述VE衍生物为VE醋酸酯。
优选的是，所述的皮肤表面用驱蚊喷剂，其中，所述成分A与所述成分B的混合具体为：采用蒸馏水对艾叶进行蒸馏生成蒸汽，7～10天内持续将高温蒸汽通入盛放一定量芳樟醇、香茅醇及香叶醇的容器内，将混有蒸汽的芳樟醇、香茅醇及香叶醇进行混合形成所述成分A，将所述成分A与所述成分B混合均匀。
优选的是，所述的皮肤表面用驱蚊喷剂，其中，所述成分C与所述成分D的混合具体为：取一定量的VE或VE衍生物，将其浸泡于少量甘油中2～5天，向其中加入麻黄碱；将一定量的卵磷脂、茯苓提取物及天然角鲨烷依次加入甘油中，浸泡2～5天，每日振荡3～6次，每次5～10分钟；将加入麻黄碱的含VE或VE衍生物的甘油混合物快速加入至含卵磷脂、茯苓提取物及天然角鲨烷的甘油混合物中，加入适量水，振荡10～30分钟，温度为20-40℃，得到所述成分C与所述成分D的混合物。
优选的是，所述的皮肤表面用驱蚊喷剂，其中，将制得的所述成分A和所述成分B的混合物与所述成分C和所述成分D的混合物进行再混合，在压力为0.5～1.33kPa下加热至100～120℃，持续3～10分钟后，降温至60～70℃，对混合液进行过滤去渣，再进行高压蒸汽灭菌，即得防治蚊虫叮咬的喷剂。
优选的是，所述的皮肤表面用驱蚊喷剂，其中，成分A与成分B的混合物中还包括西红花。
优选的是，所述的皮肤表面用驱蚊喷剂，其中，取0.2～1g所述西红花浸泡于200～600mL水中，浸泡20～40分钟后，加热熬煮至水剩余60～200mL，取上层淸液以质量比为1:6～1:10加入至所述成分A与成分B的混合物中。
本发明至少包括以下有益效果：
1、采用芳樟醇、香茅醇及香叶醇作为防蚊用主要功能性成分，用蒸馏水对艾叶进行蒸馏生成蒸汽，利用蒸汽熏蒸芳樟醇、香茅醇及香叶醇，使芳樟醇、香茅醇及香叶醇中融合艾叶活性成分，从而适宜人体皮肤直接接触；
2、经艾叶蒸汽熏蒸过的芳樟醇、香茅醇及香叶醇按一定比例混合，既能达到驱蚊防蚊效果，又适宜人体皮肤使用；
3、艾叶精油与芳樟醇、香茅醇及香叶醇混合，艾叶精油分子分别与芳樟醇、香茅醇及香叶醇分子进行结合后，再通过艾叶精油分子之间的相容性，使四种成分充分融合，从而增强各自的防蚊效果；
4、卵磷脂、茯苓提取物及天然角鲨烷既能增强皮肤自防御能力，又能增强皮肤对于艾叶精油、芳樟醇、香茅醇及香叶醇混合成分的适应性，增强功能成分在皮肤表面的吸附，使喷剂具有持久驱蚊效果；
5、加入麻黄碱的VE或VE衍生物是活性成分，其能激活成分C与成分D的混合物对于成分A与成分B混合物的活性，使功能成分A被包覆于成分B、C、D形成的油性膜中，保持其持久功能性，且延缓其释放，从而增强喷剂的持久性及在皮肤表面的吸附性；
6、对于添加有西红花的喷剂既可以喷涂于已被蚊虫叮咬的患处，也可作常规使用，将定量西红花上清液加入至所述成分A与成分B的混合物中，使西红花吸附于艾叶精油分子表面，从而提高皮肤的舒适性。
本发明的其它优点、目标和特征将部分通过下面的说明体现，部分还将通过对本发明的研究和实践而为本领域的技术人员所理解。
具体实施方式
下面结合实施例对本发明做进一步的详细说明，以令本领域技术人员参照说明书文字能够据以实施。
应当理解，本文所使用的诸如“具有”、“包含”以及“包括”术语并不配出一个或多个其它元件或其组合的存在或添加。
本发明提供一种皮肤表面用驱蚊喷剂，其包含以下成分(按质量分数计)：
成分A：芳樟醇：香茅醇：香叶醇为1:1:1～1:4:1；
成分B：艾叶精油；
成分C：卵磷脂，2～5份；麻黄碱，0.001～0.1份；茯苓提取物，0.005～0.1份；天然角鲨烷，2～10份；VE或VE衍生物，0.5～5份；
成分D：甘油，5～15份；余量为水；
其中成分A与成分B以1:2～1:1比例混合均匀，成分C与成分D混合均匀后，再将成分A与成分B的混合物加入；成分A与成分B的混合物：成分C与成分D的混合物为9:41～3:7。
其中，所述VE衍生物为VE醋酸酯。
所述成分A与所述成分B的混合具体为：采用蒸馏水对艾叶进行蒸馏生成蒸汽，7～10天内持续将高温蒸汽通入盛放一定量芳樟醇、香茅醇及香叶醇的容器内，将混有蒸汽的芳樟醇、香茅醇及香叶醇进行混合形成所述成分A，将所述成分A与所述成分B混合均匀。
所述成分C与所述成分D的混合具体为：取一定量的VE或VE衍生物，将其浸泡于少量甘油中2～5天，向其中加入麻黄碱；将一定量的卵磷脂、茯苓提取物及天然角鲨烷依次加入甘油中，浸泡2～5天，每日振荡3～6次，每次5～10分钟；将加入麻黄碱的含VE或VE衍生物的甘油混合物快速加入至含卵磷脂、茯苓提取物及天然角鲨烷的甘油混合物中，加入适量水，振荡10～30分钟，温度为20-40℃，得到所述成分C与所述成分D的混合物。
将制得的所述成分A和所述成分B的混合物与所述成分C和所述成分D的混合物进行再混合，在压力为0.5～1.33kPa下加热至100～120℃，持续3～10分钟后，降温至60～70℃，对混合液进行过滤去渣，再进行高压蒸汽灭菌，即得防治蚊虫叮咬的喷剂。
具体应用如下：
实施例1
芳樟醇，2份；
香茅醇，2份；
香叶醇，2份；
艾叶精油，12份；
卵磷脂，2份；
茯苓提取物，0.005份；
天然角鲨烷，2份；
VE或VE衍生物，0.5份；
麻黄碱，0.001份；
甘油，5份；
余量为水。
所述成分A与所述成分B的混合具体为：采用蒸馏水对艾叶进行蒸馏生成蒸汽，7天内持续将高温蒸汽通入盛放一定量芳樟醇、香茅醇及香叶醇的容器内，将混有蒸汽的芳樟醇、香茅醇及香叶醇进行混合形成所述成分A，将所述成分A与所述成分B混合均匀。
所述成分C与所述成分D的混合具体为：取一定量的VE或VE衍生物，将其浸泡于少量甘油中2天，向其中加入麻黄碱；将一定量的卵磷脂、茯苓提取物及天然角鲨烷依次加入甘油中，浸泡2天，每日振荡3次，每次5分钟；将加入麻黄碱的含VE或VE衍生物的甘油混合物快速加入至含卵磷脂、茯苓提取物及天然角鲨烷的甘油混合物中，加入适量水，振荡10分钟，温度为20℃，得到所述成分C与所述成分D的混合物。
将制得的所述成分A和所述成分B的混合物与所述成分C和所述成分D的混合物进行再混合，在压力为0.5kPa下加热至100℃，持续3分钟后，降温至60℃，对混合液进行过滤去渣，再进行高压蒸汽灭菌，即得防治蚊虫叮咬的喷剂。
实施例2
芳樟醇，2份；
香茅醇，8份；
香叶醇，2份；
艾叶精油，12份；
卵磷脂，5份；
茯苓提取物，0.1份；
天然角鲨烷，10份；
VE或VE衍生物，5份；
麻黄碱，0.1份；
甘油，15份；
余量为水。
所述成分A与所述成分B的混合具体为：采用蒸馏水对艾叶进行蒸馏生成蒸汽，8天内持续将高温蒸汽通入盛放一定量芳樟醇、香茅醇及香叶醇的容器内，将混有蒸汽的芳 樟醇、香茅醇及香叶醇进行混合形成所述成分A，将所述成分A与所述成分B混合均匀。
所述成分C与所述成分D的混合具体为：取一定量的VE或VE衍生物，将其浸泡于少量甘油中3天，向其中加入麻黄碱；将一定量的卵磷脂、茯苓提取物及天然角鲨烷依次加入甘油中，浸泡3天，每日振荡5次，每次8分钟；将加入麻黄碱的含VE或VE衍生物的甘油混合物快速加入至含卵磷脂、茯苓提取物及天然角鲨烷的甘油混合物中，加入适量水，振荡20分钟，温度为30℃，得到所述成分C与所述成分D的混合物。
将制得的所述成分A和所述成分B的混合物与所述成分C和所述成分D的混合物进行再混合，在压力为1kPa下加热至110℃，持续5分钟后，降温至62℃，对混合液进行过滤去渣，再进行高压蒸汽灭菌，即得防治蚊虫叮咬的喷剂。
实施例3
芳樟醇，5份；
香茅醇，5份；
香叶醇，5份；
艾叶精油，15份；
卵磷脂，3份；
茯苓提取物，0.05份；
天然角鲨烷，8份；
VE或VE衍生物，2份；
麻黄碱，0.1份；
甘油，10份；
余量为水。
所述成分A与所述成分B的混合具体为：采用蒸馏水对艾叶进行蒸馏生成蒸汽，10天内持续将高温蒸汽通入盛放一定量芳樟醇、香茅醇及香叶醇的容器内，将混有蒸汽的芳樟醇、香茅醇及香叶醇进行混合形成所述成分A，将所述成分A与所述成分B混合均匀。
所述成分C与所述成分D的混合具体为：取一定量的VE或VE衍生物，将其浸泡于少量甘油中5天，向其中加入麻黄碱；将一定量的卵磷脂、茯苓提取物及天然角鲨烷依次加入甘油中，浸泡5天，每日振荡6次，每次10分钟；将加入麻黄碱的含VE或VE衍生 物的甘油混合物快速加入至含卵磷脂、茯苓提取物及天然角鲨烷的甘油混合物中，加入适量水，振荡30分钟，温度为40℃，得到所述成分C与所述成分D的混合物。
将制得的所述成分A和所述成分B的混合物与所述成分C和所述成分D的混合物进行再混合，在压力为1.33kPa下加热至120℃，持续10分钟后，降温至70℃，对混合液进行过滤去渣，再进行高压蒸汽灭菌，即得防治蚊虫叮咬的喷剂。
实施例4
芳樟醇，3份；
香茅醇，6份；
香叶醇，3份；
艾叶精油，12份；
卵磷脂，2份；
茯苓提取物，0.01份；
天然角鲨烷，2份；
VE，0.5份；
麻黄碱，0.001份；
甘油，10份；
余量为水；
其中，所述成分A与所述成分B的混合具体为：采用蒸馏水对艾叶进行蒸馏生成蒸汽，8天内持续将高温蒸汽通入盛放一定量芳樟醇、香茅醇及香叶醇的容器内，将混有蒸汽的芳樟醇、香茅醇及香叶醇进行混合形成所述成分A，将所述成分A与所述成分B混合均匀。
取1g所述西红花浸泡于600mL水中，浸泡40分钟后，加热熬煮至水剩余200mL，取上层淸液以质量比为1:6加入至所述成分A与成分B的混合物中。
所述成分C与所述成分D的混合具体为：取一定量的VE或VE衍生物，将其浸泡于少量甘油中3天，向其中加入麻黄碱；将一定量的卵磷脂、茯苓提取物及天然角鲨烷依次加入甘油中，浸泡3天，每日振荡4次，每次5分钟；将加入麻黄碱的含VE或VE衍生物的甘油混合物快速加入至含卵磷脂、茯苓提取物及天然角鲨烷的甘油混合物中，加入适 量水，振荡15分钟，温度为20℃，得到所述成分C与所述成分D的混合物。
将制得的含有西红花的所述成分A和所述成分B的混合物与所述成分C和所述成分D的混合物进行再混合，在压力为0.8kPa下加热至100℃，持续5分钟后，降温至60℃，对混合液进行过滤去渣，再进行高压蒸汽灭菌，即得防治蚊虫叮咬的喷剂。
实施例5
芳樟醇，2份；
香茅醇，6份；
香叶醇，2份；
艾叶精油，20份；
卵磷脂，5份；
茯苓提取物，0.1份；
天然角鲨烷，7份；
VE或VE衍生物，5份；
麻黄碱，0.1份；
甘油，15份；
余量为水。
其中，所述成分A与所述成分B的混合具体为：采用蒸馏水对艾叶进行蒸馏生成蒸汽，9天内持续将高温蒸汽通入盛放一定量芳樟醇、香茅醇及香叶醇的容器内，将混有蒸汽的芳樟醇、香茅醇及香叶醇进行混合形成所述成分A，将所述成分A与所述成分B混合均匀。
取0.7g所述西红花浸泡于400mL水中，浸泡35分钟后，加热熬煮至水剩余150mL，取上层淸液以质量比为1:10加入至所述成分A与成分B的混合物中。
所述成分C与所述成分D的混合具体为：取一定量的VE或VE衍生物，将其浸泡于少量甘油中4天，向其中加入麻黄碱；将一定量的卵磷脂、茯苓提取物及天然角鲨烷依次加入甘油中，浸泡4天，每日振荡4次，每次6分钟；将加入麻黄碱的含VE或VE衍生物的甘油混合物快速加入至含卵磷脂、茯苓提取物及天然角鲨烷的甘油混合物中，加入适量水，振荡22分钟，温度为25℃，得到所述成分C与所述成分D的混合物。
将制得的含有西红花的所述成分A和所述成分B的混合物与所述成分C和所述成分D的混合物进行再混合，在压力为1.2kPa下加热至100℃，持续5分钟后，降温至65℃，对混合液进行过滤去渣，再进行高压蒸汽灭菌，即得防治蚊虫叮咬的喷剂。
将实施例1、实施例2及实施例3制得的喷剂与市售防治蚊虫喷剂进行比较，发现实施例3中的喷剂持久性>实施例2>实施例1>市售产品，擦拭于人体皮肤表面，实施例3使用效果最佳。
将实施例3、实施例4及实施例5制得的喷剂进行比较，发现实施例3的防蚊喷剂持久性>实施例4>实施例5，实施例5的舒适性最佳。
对本发明的应用、修改和变化对本领域的技术人员来说是显而易见的。
尽管本发明的实施方案已公开如上，但其并不仅仅限于说明书和实施方式中所列运用，它完全可以被适用于各种适合本发明的领域，对于熟悉本领域的人员而言，可容易地实现另外的修改，因此在不背离权利要求及等同范围所限定的一般概念下，本发明并不限于特定的细节和这里示出的实施例。

Claims (10)

  1. 一种皮肤表面用驱蚊喷剂，其特征在于，包含以下成分(按质量分数计)：
    成分A：芳樟醇：香茅醇：香叶醇为1:1:1～1:4:1；
    成分B：艾叶精油；
    成分C：卵磷脂，2～5份；麻黄碱，0.001～0.1份；茯苓提取物，0.005～0.1份；天然角鲨烷，2～10份；VE或VE衍生物，0.5～5份；
    成分D：甘油，5～15份；余量为水；
    其中成分A与成分B以1:2～1:1比例混合均匀，成分C与成分D混合均匀后，再将成分A与成分B的混合物加入；成分A与成分B的混合物：成分C与成分D的混合物为9:41～3:7。
  2. 如权利要求1所述的皮肤表面用驱蚊喷剂，其特征在于，包含以下成分(按质量分数计)：
    芳樟醇，2份；
    香茅醇，2份；
    香叶醇，2份；
    艾叶精油，12份；
    卵磷脂，2份；
    茯苓提取物，0.005份；
    天然角鲨烷，2份；
    VE或VE衍生物，0.5份；
    麻黄碱，0.001份；
    甘油，5份；
    余量为水。
  3. 如权利要求1所述的皮肤表面用驱蚊喷剂，其特征在于，包含以下成分(按质量分数计)：
    芳樟醇，2份；
    香茅醇，8份；
    香叶醇，2份；
    艾叶精油，12份；
    卵磷脂，5份；
    茯苓提取物，0.1份；
    天然角鲨烷，10份；
    VE或VE衍生物，5份；
    麻黄碱，0.1份；
    甘油，15份；
    余量为水。
  4. 如权利要求1所述的皮肤表面用驱蚊喷剂，其特征在于，包含以下成分(按质量分数计)：
    芳樟醇，5份；
    香茅醇，5份；
    香叶醇，5份；
    艾叶精油，15份；
    卵磷脂，3份；
    茯苓提取物，0.05份；
    天然角鲨烷，8份；
    VE或VE衍生物，2份；
    麻黄碱，0.1份；
    甘油，10份；
    余量为水。
  5. 如权利要求1至4任一项所述的皮肤表面用驱蚊喷剂，其特征在于，所述VE衍生物为VE醋酸酯。
  6. 如权利要求5所述的皮肤表面用驱蚊喷剂，其特征在于，所述成分A与所述成分 B的混合具体为：采用蒸馏水对艾叶进行蒸馏生成蒸汽，7～10天内持续将高温蒸汽通入盛放一定量芳樟醇、香茅醇及香叶醇的容器内，将混有蒸汽的芳樟醇、香茅醇及香叶醇进行混合形成所述成分A，将所述成分A与所述成分B混合均匀。
  7. 如权利要求6所述的皮肤表面用驱蚊喷剂，其特征在于，所述成分C与所述成分D的混合具体为：取一定量的VE或VE衍生物，将其浸泡于少量甘油中2～5天，向其中加入麻黄碱；将一定量的卵磷脂、茯苓提取物及天然角鲨烷依次加入甘油中，浸泡2～5天，每日振荡3～6次，每次5～10分钟；将加入麻黄碱的含VE或VE衍生物的甘油混合物快速加入至含卵磷脂、茯苓提取物及天然角鲨烷的甘油混合物中，加入适量水，振荡10～30分钟，温度为20-40℃，得到所述成分C与所述成分D的混合物。
  8. 如权利要求7所述的皮肤表面用驱蚊喷剂，其特征在于，将制得的所述成分A和所述成分B的混合物与所述成分C和所述成分D的混合物进行再混合，在压力为0.5～1.33kPa下加热至100～120℃，持续3～10分钟后，降温至60～70℃，对混合液进行过滤去渣，再进行高压蒸汽灭菌，即得防治蚊虫叮咬的喷剂。
  9. 如权利要求1所述的皮肤表面用驱蚊喷剂，其特征在于，成分A与成分B的混合物中还包括西红花。
  10. 如权利要求9所述的皮肤表面用驱蚊喷剂，其特征在于，取0.2～1g所述西红花浸泡于200～600mL水中，浸泡20～40分钟后，加热熬煮至水剩余60～200mL，取上层淸液以质量比为1:6～1:10加入至所述成分A与成分B的混合物中。
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