WO2017219579A1 - 长效抑菌型漱口水 - Google Patents

长效抑菌型漱口水 Download PDF

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WO2017219579A1
WO2017219579A1 PCT/CN2016/104827 CN2016104827W WO2017219579A1 WO 2017219579 A1 WO2017219579 A1 WO 2017219579A1 CN 2016104827 W CN2016104827 W CN 2016104827W WO 2017219579 A1 WO2017219579 A1 WO 2017219579A1
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PCT/CN2016/104827
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吴克
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江苏奇力康皮肤药业有限公司
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18

Definitions

  • the invention relates to a mouthwash, in particular to a long-acting bacteriostatic mouthwash.
  • Gingivitis is a common disease of the periodontal tissue. It is caused by inadvertent oral hygiene, long-term stimulation caused by soft tartar and hard tartar formed by food residue, bacteria and other teeth around the teeth, and incorrect oral cavity. Health habits, vitamin deficiency and other reasons.
  • Some mouthwashes have poor anti-inflammatory and antibacterial effects, and the antibacterial time is short, which can not really achieve the antibacterial and anti-inflammatory effects.
  • the long-acting bacteriostatic mouthwash wherein the cork extract is contained in an amount of 0.1 to 0.3% by weight.
  • the long-acting bacteriostatic mouthwash wherein the capillar extract is contained in an amount of 0.1 to 0.3% by weight.
  • the long-acting bacteriostatic mouthwash wherein the extract of Andrographis paniculata is 0.1 to 0.3% by weight.
  • the long-acting bacteriostatic mouthwash wherein the verbena extract is contained in an amount of 0.1 to 0.3% by weight.
  • the long-acting bacteriostatic mouthwash further comprises a humectant, a surfactant, a sweetener, a flavor, a cooling agent and a preservative.
  • the long-acting bacteriostatic mouthwash wherein the humectant is selected from the group consisting of sorbitol, a propylene glycol or a combination thereof; the humectant is contained in an amount of 10 to 45 wt%;
  • the surfactant is selected from sodium lauryl sulfate, poloxamer, polysorbate or a combination thereof; the surfactant is present in an amount of 2 to 5 wt%;
  • the sweetener is selected from the group consisting of saccharin, sodium saccharin, aspartame, stevioside, sucralose, xylitol or a combination thereof; the sweetener is present in an amount of 0.1 to 0.5% by weight;
  • the flavor is selected from the group consisting of mint flavor, spearmint flavor, green tea flavor, milk flavor, fruit flavor, or a combination thereof; the flavor is in an amount of 0.1 to 0.5% by weight;
  • the cooling agent is selected from the group consisting of borneol, menthol or a combination thereof; the content of the cooling agent is 0.1 to 0.3% by weight;
  • the preservative is selected from the group consisting of benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, methylparaben, propylparaben, butylparaben or a combination thereof; the content of the preservative is 0.05 to 0.2 Wt%.
  • the method of using the combination of Cortex extract, Capillar extract, Andrographis paniculata extract and Verbena extract can quickly prevent gum bleeding and long-term inhibition of oral bacteria, and achieve both the symptoms and the root causes. the goal of.
  • a long-acting bacteriostatic mouthwash having a deionized water as a main component and at least a combination of a cortex extract, a capillaris extract, an andrographis extract and a verbena extract is added.
  • the traditional Chinese medicine extract herein refers to a solid obtained by extracting a Chinese medicine by a solvent and then removing the solvent.
  • Cortex extract, Capillar extract, Andrographis paniculata extract and Verbena extract are an inseparable organic whole, and the four components can promote each other to produce synergistic effects, and jointly improve the antibacterial ability and antibacterial time of the mouthwash.
  • the content of these four components should be limited, as follows:
  • the content of the cortex extract is preferably from 0.1 to 0.3% by weight.
  • the content of the extract of Capillaris is preferably from 0.1 to 0.3% by weight.
  • the content of the Andrographis paniculata extract is preferably from 0.1 to 0.3% by weight.
  • the content of the verbena extract is preferably from 0.1 to 0.3% by weight.
  • a moisturizer As another embodiment of the present invention, a moisturizer, a surfactant, a sweetener, and a fragrance are also included. Materials, cooling agents and preservatives.
  • the humectant is selected from the group consisting of sorbitol, propylene glycol or a combination thereof; the content of the humectant is 10 to 45 wt%;
  • the surfactant is selected from sodium lauryl sulfate, poloxamer, polysorbate or a combination thereof; the surfactant is contained in an amount of 2 to 5 wt%;
  • the sweetener is selected from the group consisting of saccharin, sodium saccharin, aspartame, stevioside, sucralose, xylitol or a combination thereof; the sweetener is contained in an amount of 0.1 to 0.5% by weight;
  • the fragrance is selected from the group consisting of mint flavor, spearmint spice, green tea flavor, milk flavor, fruit flavor, or a combination thereof; the content of the flavor is 0.1 to 0.5 wt%;
  • the cooling agent is selected from the group consisting of borneol, menthol or a combination thereof; the content of the cooling agent is 0.1 to 0.3% by weight;
  • the preservative is selected from the group consisting of benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, methylparaben, propylparaben, butylparaben or a combination thereof; the content of the preservative is 0.05 to 0.2% by weight.
  • Table 1 lists the specific components and their contents of the different examples, wherein the balance outside each component is deionized water, and the sum of each component and deionized water is 100%. Deionized water is omitted in Table 1.
  • Example 1 Example 2 Example 3 Example 4 Cork extract 0.1wt% 0.3wt% 0.2wt% 0.1wt% Capillaris extract 0.1wt% 0.3wt% 0.2wt% 0.3wt% Andrographis extract 0.1wt% 0.3wt% 0.2wt% 0.1wt% Verbena extract 0.1wt% 0.3wt% 0.2wt% 0.3wt% moisturizer 10wt% 45wt% 30wt% 45wt% Surfactant 2wt% 5wt% 3wt% 5wt% Sweetener 0.1wt% 0.5wt% 0.3wt% 0.5wt% spices 0.1wt% 0.5wt% 0.3wt% 0.5wt% Cooling agent 0.1wt% 0.3wt% 0.2wt% 0.3wt% preservative 0.05wt% 0.2wt% 0.1wt% 0.2wt% 0.2wt% 0.2wt% 0.2wt% preservative 0.05wt%
  • Table 2 lists the results of the antibacterial experiments of Examples 1-4.

Abstract

一种长效抑菌漱口水，其以去离子水为主要成分，并且包含黄柏提取物、茵陈提取物、穿心莲和马鞭草提取物的组合。所述漱口水能够防止牙龈出血，抑制口腔细菌。

Description

长效抑菌型漱口水 技术领域
本发明涉及一种漱口水，具体涉及一种长效抑菌型漱口水。
背景技术
牙龈炎是常见的牙周组织疾病，是由于不注意口腔卫生，牙齿受到牙齿周围食物残渣、细菌等物结成的软质的牙垢和硬质的牙石所致的长期刺激，以及不正确的口腔卫生习惯，维生素缺乏等原因所造成。
目前市场上也存在一些质量参差不齐的漱口水，有些漱口水的消炎抑菌效果较差，抑菌时间较短，无法真正实现抗菌消炎的功效。
发明内容
针对现有技术的不足之处，本发明的目的在于提供一种长效抑菌型漱口水，其能起到防止牙龈出血，有效抑制口腔细菌的目的。
本发明的技术方案概述如下：
一种长效抑菌型漱口水，其以去离子水为主要成分，并且至少添加有黄柏提取物、茵陈提取物、穿心莲提取物和马鞭草提取物的组合。
优选的是，所述的长效抑菌型漱口水，其中，所述黄柏提取物的含量为0.1～0.3wt％。
优选的是，所述的长效抑菌型漱口水，其中，所述茵陈提取物的含量为0.1～0.3wt％。
优选的是，所述的长效抑菌型漱口水，其中，所述穿心莲提取物的含量为0.1～0.3wt％。
优选的是，所述的长效抑菌型漱口水，其中，所述马鞭草提取物的含量为0.1～0.3wt％。
优选的是，所述的长效抑菌型漱口水，其中，还包括保湿剂、表面活性剂、甜味剂、香料、清凉剂和防腐剂。
优选的是，所述的长效抑菌型漱口水，其中，所述保湿剂选自山梨醇、 丙二醇或其组合；所述保湿剂的含量为10～45wt％；
所述表面活性剂选自月桂醇硫酸酯钠、泊洛沙姆、聚山梨醇酯或其组合；所述表面活性剂的含量为2～5wt％；
所述甜味剂选自糖精、糖精钠、阿斯巴甜、甜菊糖、三氯蔗糖、木糖醇或其组合；所述甜味剂的含量为0.1～0.5wt％；
所述香料选自薄荷香料、留兰香料、绿茶香料、牛奶香精、水果类香料或其组合；所述香料的含量为0.1～0.5wt％；
所述清凉剂选自冰片、薄荷脑或其组合；所述清凉剂的含量为0.1～0.3wt％；
所述防腐剂选自苯甲酸、苯甲酸钠、山梨酸、山梨酸钾、尼泊金甲酯、尼泊金丙酯、尼泊金丁酯或其组合；所述防腐剂的含量为0.05～0.2wt％。
本发明的有益效果是：本案采用黄柏提取物、茵陈提取物、穿心莲提取物和马鞭草提取物联合使用的方式，能够起到快速防止牙龈出血，长效抑制口腔细菌的功效，达到标本兼治的目的。
具体实施方式
下面结合实施例对本发明做进一步的详细说明，以令本领域技术人员参照说明书文字能够据以实施。
本案提出一实施例的长效抑菌型漱口水，其以去离子水为主要成分，并且至少添加有黄柏提取物、茵陈提取物、穿心莲提取物和马鞭草提取物的组合。这里的中药提取物指的是采用溶剂萃取中药后，再除去溶剂后所得到的固体物。黄柏提取物、茵陈提取物、穿心莲提取物和马鞭草提取物是一个密不可分的有机整体，四种成分之间能够相互促进产生协效作用，共同提高漱口水的抗菌能力和抑菌时间。并且，这四种成分的含量应被限定，具体如下：
在上述实施例中，黄柏提取物的含量优选为0.1～0.3wt％。
在上述实施例中，茵陈提取物的含量优选为0.1～0.3wt％。
在上述实施例中，穿心莲提取物的含量优选为0.1～0.3wt％。
在上述实施例中，马鞭草提取物的含量优选为0.1～0.3wt％。
作为本案另一实施例，其中，还包括保湿剂、表面活性剂、甜味剂、香 料、清凉剂和防腐剂。
在该实施例中，保湿剂选自山梨醇、丙二醇或其组合；保湿剂的含量为10～45wt％；
表面活性剂选自月桂醇硫酸酯钠、泊洛沙姆、聚山梨醇酯或其组合；表面活性剂的含量为2～5wt％；
甜味剂选自糖精、糖精钠、阿斯巴甜、甜菊糖、三氯蔗糖、木糖醇或其组合；甜味剂的含量为0.1～0.5wt％；
香料选自薄荷香料、留兰香料、绿茶香料、牛奶香精、水果类香料或其组合；香料的含量为0.1～0.5wt％；
清凉剂选自冰片、薄荷脑或其组合；清凉剂的含量为0.1～0.3wt％；
防腐剂选自苯甲酸、苯甲酸钠、山梨酸、山梨酸钾、尼泊金甲酯、尼泊金丙酯、尼泊金丁酯或其组合；防腐剂的含量为0.05～0.2wt％。
表一列出不同实施例的具体成分及其含量，其中各成分之外的余量为去离子水，各成分与去离子水的总和为100％，表一中略去了去离子水。
表一
  实施例1 实施例2 实施例3 实施例4
黄柏提取物 0.1wt％ 0.3wt％ 0.2wt％ 0.1wt％
茵陈提取物 0.1wt％ 0.3wt％ 0.2wt％ 0.3wt％
穿心莲提取物 0.1wt％ 0.3wt％ 0.2wt％ 0.1wt％
马鞭草提取物 0.1wt％ 0.3wt％ 0.2wt％ 0.3wt％
保湿剂 10wt％ 45wt％ 30wt％ 45wt％
表面活性剂 2wt％ 5wt％ 3wt％ 5wt％
甜味剂 0.1wt％ 0.5wt％ 0.3wt％ 0.5wt％
香料 0.1wt％ 0.5wt％ 0.3wt％ 0.5wt％
清凉剂 0.1wt％ 0.3wt％ 0.2wt％ 0.3wt％
防腐剂 0.05wt％ 0.2wt％ 0.1wt％ 0.2wt％
本案选取牙龈卟啉单胞菌、中间普雷沃氏菌、粘性放线菌、大肠杆菌、金黄色葡萄球菌这五种菌并参考GB 15979-2002附录C3进行抗菌实验。
表二列出了实施例1-4的抗菌实验结果。
表二
Figure PCTCN2016104827-appb-000001
尽管本发明的实施方案已公开如上，但其并不仅仅限于说明书和实施方式中所列运用，它完全可以被适用于各种适合本发明的领域，对于熟悉本领域的人员而言，可容易地实现另外的修改，因此在不背离权利要求及等同范围所限定的一般概念下，本发明并不限于特定的细节和这里示出的实施例。

Claims (7)

  1. 一种长效抑菌型漱口水，其特征在于，其以去离子水为主要成分，并且至少添加有黄柏提取物、茵陈提取物、穿心莲提取物和马鞭草提取物的组合。
  2. 根据权利要求1所述的长效抑菌型漱口水，其特征在于，所述黄柏提取物的含量为0.1～0.3wt％。
  3. 根据权利要求1所述的长效抑菌型漱口水，其特征在于，所述茵陈提取物的含量为0.1～0.3wt％。
  4. 根据权利要求1所述的长效抑菌型漱口水，其特征在于，所述穿心莲提取物的含量为0.1～0.3wt％。
  5. 根据权利要求1所述的长效抑菌型漱口水，其特征在于，所述马鞭草提取物的含量为0.1～0.3wt％。
  6. 根据权利要求1所述的长效抑菌型漱口水，其特征在于，还包括保湿剂、表面活性剂、甜味剂、香料、清凉剂和防腐剂。
  7. 根据权利要求6所述的长效抑菌型漱口水，其特征在于，所述保湿剂选自山梨醇、丙二醇或其组合；所述保湿剂的含量为10～45wt％；
    所述表面活性剂选自月桂醇硫酸酯钠、泊洛沙姆、聚山梨醇酯或其组合；所述表面活性剂的含量为2～5wt％；
    所述甜味剂选自糖精、糖精钠、阿斯巴甜、甜菊糖、三氯蔗糖、木糖醇或其组合；所述甜味剂的含量为0.1～0.5wt％；
    所述香料选自薄荷香料、留兰香料、绿茶香料、牛奶香精、水果类香料或其组合；所述香料的含量为0.1～0.5wt％；
    所述清凉剂选自冰片、薄荷脑或其组合；所述清凉剂的含量为0.1～0.3wt％；
    所述防腐剂选自苯甲酸、苯甲酸钠、山梨酸、山梨酸钾、尼泊金甲酯、尼泊金丙酯、尼泊金丁酯或其组合；所述防腐剂的含量为0.05～0.2wt％。
PCT/CN2016/104827 2016-06-21 2016-11-07 长效抑菌型漱口水 WO2017219579A1 (zh)

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CN106344477A (zh) * 2016-11-09 2017-01-25 江西诚志日化有限公司 一种含竹汁的漱口水
CN107693430A (zh) * 2017-11-08 2018-02-16 江西草珊瑚消毒用品有限公司 草本调理抑菌漱口液

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