WO2017206015A1 - 长效抑菌护齿含漱液 - Google Patents

长效抑菌护齿含漱液 Download PDF

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WO2017206015A1
WO2017206015A1 PCT/CN2016/083895 CN2016083895W WO2017206015A1 WO 2017206015 A1 WO2017206015 A1 WO 2017206015A1 CN 2016083895 W CN2016083895 W CN 2016083895W WO 2017206015 A1 WO2017206015 A1 WO 2017206015A1
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extract
long
weight
flavor
combination
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PCT/CN2016/083895
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吴克
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江苏奇力康皮肤药业有限公司
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Priority to CN201680000514.4A priority Critical patent/CN107921078A/zh
Priority to PCT/CN2016/083895 priority patent/WO2017206015A1/zh
Publication of WO2017206015A1 publication Critical patent/WO2017206015A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/19—Acanthaceae (Acanthus family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287—Chrysanthemum, e.g. daisy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288—Taraxacum (dandelion)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A61K36/575—Magnolia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708—Rheum (rhubarb)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734—Crataegus (hawthorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8964—Anemarrhena
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Definitions

  • the invention relates to a gargle-containing liquid, in particular to a long-acting antibacterial tooth-containing gargle.
  • Gingivitis is a common disease of the periodontal tissue. It is caused by inadvertent oral hygiene, long-term stimulation caused by soft tartar and hard tartar formed by food residue, bacteria and other teeth around the teeth, and incorrect oral cavity. Health habits, vitamin deficiency and other reasons.
  • the object of the present invention is to provide a long-acting antibacterial tooth-containing gargle which can prevent inflammation, prevent gum bleeding, and effectively inhibit oral bacteria.
  • the long-acting bacteriostatic tooth-containing gargle contains the honokiol in an amount of 0.1 to 0.3% by weight.
  • the long-acting bacteriostatic tooth-containing gargle contains a sputum extract in an amount of 0.1 to 0.3% by weight.
  • the long-acting bacteriostatic tooth-containing gargle contains the lycium extract in an amount of 0.1 to 0.3% by weight.
  • the long-acting bacteriostatic tooth-containing gargle comprises a content of the rhubarb extract of 0.1 to 0.3% by weight.
  • the long-acting bacteriostatic tooth-containing gargle comprises 0.1 to 0.3% by weight of a dandelion extract.
  • the long-acting antibacterial tooth guard contains sputum, wherein the sputum-containing liquid further includes 0.1 to 0.3% by weight of wild chrysanthemum extract.
  • the long-acting bacteriostatic tooth-containing gargle comprises 0.1 to 0.3% by weight of a hawthorn extract.
  • the long-acting bacteriostatic tooth-containing gargle comprises a humectant, a surfactant, a sweetener, a flavor, a cooling agent and a preservative.
  • the long-acting bacteriostatic tooth-containing gargle wherein the humectant is selected from the group consisting of sorbitol, propylene glycol or a combination thereof; the humectant is contained in an amount of 10 to 45 wt%;
  • the surfactant is selected from sodium lauryl sulfate, poloxamer, polysorbate or a combination thereof; the surfactant is present in an amount of 2 to 5 wt%;
  • the sweetener is selected from the group consisting of saccharin, sodium saccharin, aspartame, stevioside, sucralose, xylitol or a combination thereof; the sweetener is present in an amount of 0.1 to 0.5% by weight;
  • the flavor is selected from the group consisting of mint flavor, spearmint flavor, green tea flavor, milk flavor, fruit flavor, or a combination thereof; the flavor is in an amount of 0.1 to 0.5% by weight;
  • the cooling agent is selected from the group consisting of borneol, menthol or a combination thereof; the content of the cooling agent is 0.1 to 0.3% by weight;
  • the preservative is selected from the group consisting of benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, methylparaben, propylparaben, butylparaben or a combination thereof; the content of the preservative is 0.05 to 0.2 Wt%.
  • the beneficial effects of the invention are as follows: in this case, the combination of magnolol, Zhimu extract, and Andrographis paniculata extract and rhubarb extract can rapidly reduce inflammation, prevent gum bleeding, effectively inhibit oral bacteria, and achieve both the symptoms and the root causes. the goal of.
  • a long-acting antibacterial tooth-containing gargle containing deionized water as a main component and at least a combination of magnolol, anemarrhena extract, andrographis extract and rhubarb extract is added.
  • the traditional Chinese medicine extract herein refers to a solid obtained by extracting a Chinese medicine by a solvent and then removing the solvent.
  • Magnolia phenol, Anemarrhenae extract, Andrographis paniculata extract and Rhubarb extract are an inseparable organic whole, and the four components can promote each other to produce a synergistic effect, and jointly improve the antibacterial solution containing sputum. Anti-inflammatory ability.
  • the content of these four components should be limited, as follows:
  • the content of magnolol is preferably from 0.1 to 0.3% by weight.
  • the content of the Zhimu extract is preferably from 0.1 to 0.3% by weight.
  • the content of the Andrographis paniculata extract is preferably from 0.1 to 0.3% by weight.
  • the content of the rhubarb extract is preferably from 0.1 to 0.3% by weight.
  • the gargle-containing liquid further comprises 0.1 to 0.3% by weight of a dandelion extract.
  • the dandelion extract can further synergistically enhance the antibacterial and anti-inflammatory ability of the gargle.
  • Wild chrysanthemum extract can further synergize with dandelion extract to improve the antibacterial and anti-inflammatory ability of gargle.
  • hawthorn extract in the mash containing liquid.
  • Hawthorn extract can further synergize with dandelion extract and wild chrysanthemum extract to enhance the antibacterial and anti-inflammatory ability of the gargle.
  • a moisturizer As another embodiment of the present invention, a moisturizer, a surfactant, a sweetener, a fragrance, a cooling agent and a preservative are also included.
  • the humectant is selected from the group consisting of sorbitol, propylene glycol or a combination thereof; the content of the humectant is 10 to 45 wt%;
  • the surfactant is selected from sodium lauryl sulfate, poloxamer, polysorbate or a combination thereof; the surfactant is contained in an amount of 2 to 5 wt%;
  • the sweetener is selected from the group consisting of saccharin, sodium saccharin, aspartame, stevioside, sucralose, xylitol or a combination thereof; the sweetener is contained in an amount of 0.1 to 0.5% by weight;
  • the fragrance is selected from the group consisting of mint flavor, spearmint spice, green tea flavor, milk flavor, fruit flavor, or a combination thereof; the content of the flavor is 0.1 to 0.5 wt%;
  • the cooling agent is selected from the group consisting of borneol, menthol or a combination thereof; the content of the cooling agent is 0.1 to 0.3% by weight;
  • the preservative is selected from the group consisting of benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, methylparaben, propylparaben, butylparaben or a combination thereof; the content of the preservative is 0.05 to 0.2% by weight.
  • Table 1 lists the specific components and their contents of the different examples, wherein the balance outside each component is deionized water, and the sum of each component and deionized water is 100%. Deionized water is omitted in Table 1.
  • Example 1 Example 2 Example 3 Example 4 Example 5
  • Table 2 lists the results of the antibacterial experiments of Examples 1-5.

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Abstract

一种抑菌护齿含漱液，以去离子水为主要成分，并且至少添加有厚朴酚、知母提取物、穿心莲提取物和大黄提取物的组合。所述含漱液能够快速消炎、防止牙龈出血，有效抑制口腔细菌。

Description

长效抑菌护齿含漱液 技术领域
本发明涉及一种含漱液，具体涉及一种长效抑菌护齿含漱液。
背景技术
牙龈炎是常见的牙周组织疾病，是由于不注意口腔卫生，牙齿受到牙齿周围食物残渣、细菌等物结成的软质的牙垢和硬质的牙石所致的长期刺激，以及不正确的口腔卫生习惯，维生素缺乏等原因所造成。
目前市场上也存在一些质量参差不齐的含漱液，有些含漱液的消炎抑菌效果较差，抑菌时间较短，无法真正实现抗菌消炎的功效。
发明内容
针对现有技术的不足之处，本发明的目的在于提供一种长效抑菌护齿含漱液，其能起到消炎、防止牙龈出血，有效抑制口腔细菌的目的。
本发明的技术方案概述如下：
一种长效抑菌护齿含漱液，其以去离子水为主要成分，并且至少添加有厚朴酚、知母提取物、穿心莲提取物和大黄提取物的组合。
优选的是，所述的长效抑菌护齿含漱液，其中，所述厚朴酚的含量为0.1～0.3wt％。
优选的是，所述的长效抑菌护齿含漱液，其中，所述知母提取物的含量为0.1～0.3wt％。
优选的是，所述的长效抑菌护齿含漱液，其中，所述穿心莲提取物的含量为0.1～0.3wt％。
优选的是，所述的长效抑菌护齿含漱液，其中，所述大黄提取物的含量为0.1～0.3wt％。
优选的是，所述的长效抑菌护齿含漱液，其中，所述含漱液中还包括有0.1～0.3wt％的蒲公英提取物。
优选的是，所述的长效抑菌护齿含漱液，其中，所述含漱液中还包括有 0.1～0.3wt％的野菊花提取物。
优选的是，所述的长效抑菌护齿含漱液，其中，所述含漱液中还包括有0.1～0.3wt％的山楂提取物。
优选的是，所述的长效抑菌护齿含漱液，其中，还包括保湿剂、表面活性剂、甜味剂、香料、清凉剂和防腐剂。
优选的是，所述的长效抑菌护齿含漱液，其中，所述保湿剂选自山梨醇、丙二醇或其组合；所述保湿剂的含量为10～45wt％；
所述表面活性剂选自月桂醇硫酸酯钠、泊洛沙姆、聚山梨醇酯或其组合；所述表面活性剂的含量为2～5wt％；
所述甜味剂选自糖精、糖精钠、阿斯巴甜、甜菊糖、三氯蔗糖、木糖醇或其组合；所述甜味剂的含量为0.1～0.5wt％；
所述香料选自薄荷香料、留兰香料、绿茶香料、牛奶香精、水果类香料或其组合；所述香料的含量为0.1～0.5wt％；
所述清凉剂选自冰片、薄荷脑或其组合；所述清凉剂的含量为0.1～0.3wt％；
所述防腐剂选自苯甲酸、苯甲酸钠、山梨酸、山梨酸钾、尼泊金甲酯、尼泊金丙酯、尼泊金丁酯或其组合；所述防腐剂的含量为0.05～0.2wt％。
本发明的有益效果是：本案采用厚朴酚、知母提取物、穿心莲提取物和大黄提取物联合使用的方式，能够起到快速消炎、防止牙龈出血，有效抑制口腔细菌的功效，达到标本兼治的目的。
具体实施方式
下面结合实施例对本发明做进一步的详细说明，以令本领域技术人员参照说明书文字能够据以实施。
本案提出一实施例的长效抑菌护齿含漱液，其以去离子水为主要成分，并且至少添加有厚朴酚、知母提取物、穿心莲提取物和大黄提取物的组合。这里的中药提取物指的是采用溶剂萃取中药后，再除去溶剂后所得到的固体物。厚朴酚、知母提取物、穿心莲提取物和大黄提取物是一个密不可分的有机整体，四种成分之间能够相互促进产生协效作用，共同提高含漱液的抗菌 消炎能力。并且，这四种成分的含量应被限定，具体如下：
在上述实施例中，厚朴酚的含量优选为0.1～0.3wt％。
在上述实施例中，知母提取物的含量优选为0.1～0.3wt％。
在上述实施例中，穿心莲提取物的含量优选为0.1～0.3wt％。
在上述实施例中，大黄提取物的含量优选为0.1～0.3wt％。
作为本案另一实施例，其中，含漱液中还包括有0.1～0.3wt％的蒲公英提取物。蒲公英提取物可进一步协同提高含漱液的抗菌消炎能力。
在上述实施例中，含漱液中还优选包括有0.1～0.3wt％的野菊花提取物。野菊花提取物可进一步协同蒲公英提取物提高含漱液的抗菌消炎能力。
在上述实施例中，含漱液中还优选包括有0.1～0.3wt％的山楂提取物。山楂提取物可进一步协同蒲公英提取物和野菊花提取物提高含漱液的抗菌消炎能力。
作为本案另一实施例，其中，还包括保湿剂、表面活性剂、甜味剂、香料、清凉剂和防腐剂。
在该实施例中，保湿剂选自山梨醇、丙二醇或其组合；保湿剂的含量为10～45wt％；
表面活性剂选自月桂醇硫酸酯钠、泊洛沙姆、聚山梨醇酯或其组合；表面活性剂的含量为2～5wt％；
甜味剂选自糖精、糖精钠、阿斯巴甜、甜菊糖、三氯蔗糖、木糖醇或其组合；甜味剂的含量为0.1～0.5wt％；
香料选自薄荷香料、留兰香料、绿茶香料、牛奶香精、水果类香料或其组合；香料的含量为0.1～0.5wt％；
清凉剂选自冰片、薄荷脑或其组合；清凉剂的含量为0.1～0.3wt％；
防腐剂选自苯甲酸、苯甲酸钠、山梨酸、山梨酸钾、尼泊金甲酯、尼泊金丙酯、尼泊金丁酯或其组合；防腐剂的含量为0.05～0.2wt％。
表一列出不同实施例的具体成分及其含量，其中各成分之外的余量为去离子水，各成分与去离子水的总和为100％，表一中略去了去离子水。
表一
  实施例1 实施例2 实施例3 实施例4 实施例5
厚朴酚 0.1wt％ 0.3wt％ 0.2wt％ 0.2wt％ 0.2wt％
知母提取物 0.1wt％ 0.3wt％ 0.2wt％ 0.2wt％ 0.2wt％
穿心莲提取物 0.1wt％ 0.3wt％ 0.2wt％ 0.2wt％ 0.2wt％
大黄提取物 0.1wt％ 0.3wt％ 0.2wt％ 0.2wt％ 0.2wt％
蒲公英提取物 0 0 0.2wt％ 0.2wt％ 0.2wt％
野菊花提取物 0 0 0 0.2wt％ 0.2wt％
山楂提取物 0 0 0 0 0.2wt％
保湿剂 10wt％ 45wt％ 10wt％ 45wt％ 30wt％
表面活性剂 2wt％ 5wt％ 2wt％ 5wt％ 3wt％
甜味剂 0.1wt％ 0.5wt％ 0.1wt％ 0.5wt％ 0.3wt％
香料 0.1wt％ 0.5wt％ 0.1wt％ 0.5wt％ 0.3wt％
清凉剂 0.1wt％ 0.3wt％ 0.1wt％ 0.3wt％ 0.2wt％
防腐剂 0.05wt％ 0.2wt％ 0.05wt％ 0.2wt％ 0.1wt％
本案选取牙龈卟啉单胞菌、中间普雷沃氏菌、粘性放线菌、大肠杆菌、金黄色葡萄球菌这五种菌并参考GB 15979-2002附录C3进行抗菌实验。
表二列出了实施例1-5的抗菌实验结果。
表二
Figure PCTCN2016083895-appb-000001
Figure PCTCN2016083895-appb-000002
尽管本发明的实施方案已公开如上，但其并不仅仅限于说明书和实施方式中所列运用，它完全可以被适用于各种适合本发明的领域，对于熟悉本领域的人员而言，可容易地实现另外的修改，因此在不背离权利要求及等同范围所限定的一般概念下，本发明并不限于特定的细节和这里示出的实施例。

Claims (10)

  1. 一种长效抑菌护齿含漱液，其特征在于，其以去离子水为主要成分，并且至少添加有厚朴酚、知母提取物、穿心莲提取物和大黄提取物的组合。
  2. 根据权利要求1所述的长效抑菌护齿含漱液，其特征在于，所述厚朴酚的含量为0.1～0.3wt％。
  3. 根据权利要求1所述的长效抑菌护齿含漱液，其特征在于，所述知母提取物的含量为0.1～0.3wt％。
  4. 根据权利要求1所述的长效抑菌护齿含漱液，其特征在于，所述穿心莲提取物的含量为0.1～0.3wt％。
  5. 根据权利要求1所述的长效抑菌护齿含漱液，其特征在于，所述大黄提取物的含量为0.1～0.3wt％。
  6. 根据权利要求1所述的长效抑菌护齿含漱液，其特征在于，所述含漱液中还包括有0.1～0.3wt％的蒲公英提取物。
  7. 根据权利要求6所述的长效抑菌护齿含漱液，其特征在于，所述含漱液中还包括有0.1～0.3wt％的野菊花提取物。
  8. 根据权利要求7所述的长效抑菌护齿含漱液，其特征在于，所述含漱液中还包括有0.1～0.3wt％的山楂提取物。
  9. 根据权利要求1所述的长效抑菌护齿含漱液，其特征在于，还包括保湿剂、表面活性剂、甜味剂、香料、清凉剂和防腐剂。
  10. 根据权利要求9所述的长效抑菌护齿含漱液，其特征在于，所述保湿剂选自山梨醇、丙二醇或其组合；所述保湿剂的含量为10～45wt％；
    所述表面活性剂选自月桂醇硫酸酯钠、泊洛沙姆、聚山梨醇酯或其组合； 所述表面活性剂的含量为2～5wt％；
    所述甜味剂选自糖精、糖精钠、阿斯巴甜、甜菊糖、三氯蔗糖、木糖醇或其组合；所述甜味剂的含量为0.1～0.5wt％；
    所述香料选自薄荷香料、留兰香料、绿茶香料、牛奶香精、水果类香料或其组合；所述香料的含量为0.1～0.5wt％；
    所述清凉剂选自冰片、薄荷脑或其组合；所述清凉剂的含量为0.1～0.3wt％；
    所述防腐剂选自苯甲酸、苯甲酸钠、山梨酸、山梨酸钾、尼泊金甲酯、尼泊金丙酯、尼泊金丁酯或其组合；所述防腐剂的含量为0.05～0.2wt％。
PCT/CN2016/083895 2016-05-30 2016-05-30 长效抑菌护齿含漱液 WO2017206015A1 (zh)

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CN115429734A (zh) * 2021-10-28 2022-12-06 斯钦 一种消炎祛火的漱口水及其制备方法
CN114983874A (zh) * 2022-06-10 2022-09-02 浙江工业大学 一种中药挥发油组合物漱口液
CN114983874B (zh) * 2022-06-10 2024-02-23 浙江工业大学 一种中药挥发油组合物漱口液

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