WO2017206018A1 - 抗菌止痒中药膏剂及其制备方法 - Google Patents

抗菌止痒中药膏剂及其制备方法 Download PDF

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WO2017206018A1
WO2017206018A1 PCT/CN2016/083898 CN2016083898W WO2017206018A1 WO 2017206018 A1 WO2017206018 A1 WO 2017206018A1 CN 2016083898 W CN2016083898 W CN 2016083898W WO 2017206018 A1 WO2017206018 A1 WO 2017206018A1
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parts
extract
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traditional chinese
chinese medicine
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吴克
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江苏奇力康皮肤药业有限公司
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Priority to PCT/CN2016/083898 priority Critical patent/WO2017206018A1/zh
Priority to CN201680000517.8A priority patent/CN107847542A/zh
Publication of WO2017206018A1 publication Critical patent/WO2017206018A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288—Taraxacum (dandelion)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/904—Stemonaceae (Stemona family), e.g. croomia

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  • the invention belongs to the field of traditional Chinese medicine, and relates to a traditional Chinese medicine cream and a preparation method thereof, in particular to an antibacterial antipruritic traditional Chinese medicine ointment and a preparation method thereof.
  • Dermatitis is often referred to as a skin inflammation that indicates an allergic reaction of the skin to chemicals, proteins, bacteria, fungi, dry climates, and the like. These substances can come from the outside, such as detergents, but also from the inside, such as seafood, drugs, etc.
  • the clinical manifestations of this disease are various, and the inflammation can be acute to chronic, repeated attacks, severe itching.
  • Antihistamines mainly act as sedative itch, commonly used chlorpheniramine; 2. Antibiotics are used for infection of skin lesions, often combined with steroid hormones.
  • corticosteroid-containing drugs can be selected for mild or small dermatitis; for large-scale dermatitis or recurrent dermatitis, if long-term frequent or large-scale use of drugs containing corticosteroids, the whole body will be Or local skin has side effects, long-term large amount of topical hormones can also be percutaneously absorbed into the blood circulation, causing diabetes and so on. Most of these methods can only cure the symptoms, and the abuse of antibiotics may lead to the enhancement of bacterial resistance and the decline of the body's immune function, resulting in repeated and difficult conditions. On the contrary, the use of traditional Chinese medicine has a good effect on the prevention and treatment of dermatitis.
  • the object of the present invention is to provide an antibacterial and antipruritic traditional Chinese medicine ointment with good curative effect, short treatment period, low cost and no toxic and side effects, which can be used for treating dermatitis.
  • an antibacterial antipruritic traditional Chinese medicine ointment comprising the following components by weight: 100 parts by weight of 50% by weight ethanol water extract 4 to 10 parts; Sophora flavescens 50% by weight ethanol water extract 1 to 3 parts; acetic acid 1 to 10 parts of chlorhexidine; 2 to 8 parts of honeysuckle extract; 3 to 8 parts of dandelion extract; 3 to 8 parts of peppermint extract; 0.5 to 3 parts of borneol; 2 to 15 parts of polyethylene glycol; 15 parts; menthol 1 to 3 parts; sodium lauryl amphoacetate 0.5 to 3 parts.
  • the ratio of the polyethylene glycol 400 to the polyethylene glycol 3350 is (20 to 50): (50 to 80).
  • Another object of the present invention is to provide a method for preparing an antibacterial antipruritic traditional Chinese medicine ointment, comprising the following steps:
  • Step 1) Take honeysuckle, dandelion, mint, mash and immerse in hot water for 1 to 4 hours, then stir and hot dip, extract by hot dip, centrifuge, collect the supernatant, and concentrate the supernatant separately. Obtaining honeysuckle extract, Pugong extract, and peppermint extract;
  • Step 2) Take 100 parts of Sophora flavescens, mash and mash, then extract with 50% by weight of aqueous ethanol solution, extract and centrifuge, and evaporate the filtrate vacuum film to obtain 100% ethanol water extract and 50% by weight of Sophora flavescens. Ethanol water extract;
  • Step 3 100 parts by weight of ethanol water extract, 50% by weight of ethanol water extract, honeysuckle water extract, dandelion water extract, chlorhexidine acetate, peppermint extract, borneol, polyethylene Alcohol, glycerin, menthol and sodium lauryl amphoacetate are mixed uniformly with the above various extracts and other excipients to obtain an antibacterial antipruritic traditional Chinese medicine ointment.
  • the step 1) is immersed in hot water for 2 hours, the leaching temperature is 50-60 ° C, the leaching time is 3-5 h, and the weight ratio of the feed liquid is 1:5 to 1:10.
  • the step 2) extraction temperature is 40-70 ° C
  • the extraction time is 2-5 h
  • the feed liquid weight ratio is 1:4 to 1:10.
  • the beneficial effects of the invention are as follows: the natural Chinese medicine is compatible in the case, and the synergistic action of each raw material medicine plays the role of dispersing wind and dampness, clearing away heat and detoxifying, nourishing blood and moistening dryness, promoting blood circulation and removing blood stasis, exorcising evil spirits, antibacterial and antipruritic treatment, etc. Bacterial inhibition, specimens with the same treatment, good effect on the treatment of dermatitis, no toxic side effects. Moreover, the preparation method is simple, the treatment period is short, the administration is convenient, the cost is low, and the effective rate is more than 85%.
  • An antibacterial antipruritic traditional Chinese medicine ointment comprising the following components by weight: 100 parts of 50% by weight of ethanol water extract; 1 part of 50% by weight of ethanolic extract of Sophora flavescens; 1 part of chlorhexidine acetate; 2 parts of honeysuckle extract; 3 parts of dandelion extract; 3 parts of peppermint extract; 0.5 part of borneol; 2 parts of polyethylene glycol (polyethylene glycol 400 and polyethylene glycol 3350: 20:80); 3 parts of glycerin; menthol 1 Serving; 0.5 parts of sodium lauryl amphoacetate.
  • the preparation method comprises the following steps:
  • Step 1) Take honeysuckle, dandelion, mint, mash and immerse in hot water for 1 hour, then stir and hot leaching, the leaching temperature is 50 ° C, the leaching time is 3 h, and the ratio of material to liquid is 1:5. After hot dip, the supernatant was collected, and the supernatant was collected, and the supernatant was separately concentrated to obtain a honeysuckle extract, a Pugong extract, and a mint extract;
  • Step 2) Take 100 parts of Kushen and Kushen, mash and extract with 50% by weight aqueous solution of ethanol.
  • the extraction temperature is 40 ° C
  • the extraction time is 2 h
  • the weight ratio of the feed liquid is 1:4, and the mixture is centrifuged after extraction.
  • the filtrate vacuum film was evaporated to obtain 100 parts of 50% by weight ethanol water extract and 50% by weight ethanol water extract of Sophora flavescens;
  • Step 3 100 parts by weight of ethanol water extract, 50% by weight of ethanol water extract, honeysuckle water extract, dandelion water extract, chlorhexidine acetate, peppermint extract, borneol, polyethylene Alcohol, glycerin, menthol and sodium lauryl amphoacetate are mixed uniformly with the above various extracts and other excipients to obtain an antibacterial antipruritic traditional Chinese medicine ointment.
  • An antibacterial antipruritic traditional Chinese medicine ointment comprising the following components by weight: 100 parts of 50% by weight ethanol water extract; 3 parts of Sophora flavescens 50wt% ethanol water extract; 10 parts of chlorhexidine acetate; 8 parts of honeysuckle extract; 8 parts of dandelion extract; 8 parts of peppermint extract; 3 parts of borneol; 15 parts of polyethylene glycol (50:50 ratio of polyethylene glycol 400 and polyethylene glycol 3350); 15 parts of glycerin; 3 parts of menthol ; 3 parts of sodium lauryl acetate.
  • An antibacterial antipruritic traditional Chinese medicine ointment comprising the following components by weight: 100 parts of 50% by weight of ethanol water extract; 1 part of Sophora flavescens 50wt% ethanol water extract; 4 parts of chlorhexidine acetate; 3 parts of honeysuckle extract; 4 parts of dandelion extract; 2 parts of peppermint extract; 1 part of borneol; 3 parts of polyethylene glycol (30:70 of polyethylene glycol 400 and polyethylene glycol 3350); 5 parts of glycerin; 1 part of menthol 13 parts of sodium lauryl amphoacetate.

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Abstract

一种抗菌止痒中药膏剂，包括如下成分：百部50wt%乙醇水提取物，苦参50wt%乙醇水提取物，醋酸洗必泰，金银花提取物，蒲公英提取物，薄荷提取物，冰片，聚乙二醇，甘油，薄荷脑，月桂基两性醋酸钠，可用于治疗皮炎。

Description

抗菌止痒中药膏剂及其制备方法 技术领域
本发明属于中药领域，涉及一种中药膏及其制备方法，特别是涉及一种抗菌止痒中药膏剂及其制备方法。
背景技术
皮炎常指的是一种皮肤炎症，表示皮肤对于化学制剂、蛋白质、细菌、真菌、干燥的气候等的过敏性反应。这些物质可以来自外部如洗涤用品，也可以来自内部如吃的海鲜、药物等本病的临床表现多种多样，其炎症可由急性到慢性，反复发作，剧烈瘙痒。目前常用的治疗措施：1.抗组胺类药主要起镇静止痒作用，常用扑尔敏；2.抗生素用于感染的皮损，常与类固醇激素并用。含皮质激素的药物外搽疗效是肯定的，对轻症或范围小的皮炎可以选择；对面积大的皮炎或反复发作的皮炎，如果长期频繁或大量使用含皮质类激素的药物，会对全身或局部的皮肤有副作用，长期大量外用激素还可经皮吸收进入血运循环，引起糖尿病等。这些方法大多只能治标不治本，另外滥用抗生素可能导致细菌抗药性加强，人体免疫功能减退，致使病情反复难愈。相反使用中药对皮炎预防和治疗有较好的效果。
中医认为，风邪、湿邪、热邪、血虚、虫淫等为致病的主要原因，治疗皮炎以疏风祛湿、清热解毒、养血润燥、活血化瘀为原则，以达到驱邪扶正、止痒治愈之功效。
发明内容
针对上述不足之处，本发明的目的在于提供一种疗效好、疗程较短、成本低、无毒副作用的抗菌止痒的中药膏剂，可以用于治疗皮炎。
本发明的技术方案概述如下：一种抗菌止痒中药膏剂，包括如下重量份的成分：百部50wt％乙醇水提取物4～10份；苦参50wt％乙醇水提取物1～3份；醋酸洗必泰1～10份；金银花提取物2～8份；蒲公英提取物3～8份；薄荷提取物3～8份；冰片0.5～3份；聚乙二醇2～15份；甘油3～15份；薄荷脑1～3份；月桂基两性醋酸钠0.5～3份。
优选的是，包括如下重量份的成分：百部50wt％乙醇水提取物3～8份；苦参50wt％乙醇水提取物1～2份；醋酸洗必泰4～8份；金银花提取物3～6份；蒲公英提取物4～9份；薄荷提取物2～5份；冰片1～3份；聚乙二醇3～10份；甘油5～10份；薄荷脑1～3份；月桂基两性醋酸钠1～3份。
优选的是，所述聚乙二醇是聚乙二醇400和聚乙二醇3350的混合物。
优选的是，所述聚乙二醇400和聚乙二醇3350的比例为(20～50):(50～80)。
本发明的另一个目的是提供一种抗菌止痒中药膏剂的制备方法，包括如下步骤：
步骤1)：取金银花、蒲公英、薄荷，捣碎后分别加入热水浸泡1～4小时，再进行搅拌热浸提，热浸提后离心，收集上清液，分别将上清液浓缩，分别得到金银花提取物、蒲公提取物、薄荷提取物；
步骤2)：取百部、苦参捣碎，捣碎后用50wt％的乙醇水溶液进行提取，提取后离心分离，将滤液真空薄膜蒸发，得到百部50wt％乙醇水提取物、苦参50wt％乙醇水提取物；
步骤3)：按重量份取百部50wt％乙醇水提取物、苦参50wt％乙醇水提取物、金银花水提取物、蒲公英水提取物、醋酸洗必泰、薄荷提取物、冰片、聚乙二醇、甘油、薄荷脑以及月桂基两性醋酸钠，将上述的各种提取物及其他辅料混合均匀，得到抗菌止痒中药膏剂。
优选的是，所述步骤1)中热水浸泡2h，浸提温度为50～60℃，浸提时间为3～5h，料液重量比为1:5～1:10。
优选的是，所述步骤2)提取温度为40～70℃，提取时间为2～5h，料液重量比为1:4～1:10。
本发明的有益效果是：本案取天然中药配伍，各原料药协同作用起到疏风祛湿、清热解毒、养血润燥、活血化瘀、驱邪扶正、抗菌止痒治等作用，对病毒和细菌有抑制作用，标本同治，对治疗皮炎效果好，无毒副作用。而且其制备方法简单、疗程较短、服用方便，成本低，有效率达85％以上。
具体实施方式
下面结合实施例对本发明做进一步的详细说明，以令本领域技术人员参照说明书文字能够据以实施。
实施例1
一种抗菌止痒中药膏剂，包括如下重量份的成分：百部50wt％乙醇水提取物4份；苦参50wt％乙醇水提取物1份；醋酸洗必泰1份；金银花提取物2份；蒲公英提取物3份；薄荷提取物3份；冰片0.5份；聚乙二醇(聚乙二醇400和聚乙二醇3350的比例为:20：80)2份；甘油3份；薄荷脑1份；月桂基两性醋酸钠0.5份。
其制备方法包容如下步骤：
步骤1)：取金银花、蒲公英、薄荷，捣碎后分别加入热水浸泡1小时，再进行搅拌热浸提，浸提温度为50℃，浸提时间为3h，料液重量比为1:5；热浸提后离心，收集上清液，分别将上清液浓缩，分别得到金银花提取物、蒲公提取物、薄荷提取物；
步骤2)：取百部、苦参捣碎，捣碎后用50wt％的乙醇水溶液进行提取，提取温度为40℃，提取时间为2h，料液重量比为1:4，提取后离心分离，将滤液真空薄膜蒸发，得到百部50wt％乙醇水提取物、苦参50wt％乙醇水提取物；
步骤3)：按重量份取百部50wt％乙醇水提取物、苦参50wt％乙醇水提取物、金银花水提取物、蒲公英水提取物、醋酸洗必泰、薄荷提取物、冰片、聚乙二醇、甘油、薄荷脑以及月桂基两性醋酸钠，将上述的各种提取物及其他辅料混合均匀，得到抗菌止痒中药膏剂。
实施例2
一种抗菌止痒中药膏剂，包括如下重量份的成分：百部50wt％乙醇水提取物10份；苦参50wt％乙醇水提取物3份；醋酸洗必泰10份；金银花提取物8份；蒲公英提取物8份；薄荷提取物8份；冰片3份；聚乙二醇(聚乙二醇400和聚乙二醇3350的比例为50:50)15份；甘油15份；薄荷脑3份；月桂基两性醋酸钠3份。
其制备方法包容如下步骤：
步骤1)：取金银花、蒲公英、薄荷，捣碎后分别加入热水浸泡4小时， 再进行搅拌热浸提，浸提温度为60℃，浸提时间为5h，料液重量比为1:10；热浸提后离心，收集上清液，分别将上清液浓缩，分别得到金银花提取物、蒲公提取物、薄荷提取物；
步骤2)：取百部、苦参捣碎，捣碎后用50wt％的乙醇水溶液进行提取，提取温度为70℃，提取时间为5h，料液重量比为1:10，提取后离心分离，将滤液真空薄膜蒸发，得到百部50wt％乙醇水提取物、苦参50wt％乙醇水提取物；
步骤3)：按重量份取百部50wt％乙醇水提取物、苦参50wt％乙醇水提取物、金银花水提取物、蒲公英水提取物、醋酸洗必泰、薄荷提取物、冰片、聚乙二醇、甘油、薄荷脑以及月桂基两性醋酸钠，将上述的各种提取物及其他辅料混合均匀，得到抗菌止痒中药膏剂。
实施例3
一种抗菌止痒中药膏剂，包括如下重量份的成分：百部50wt％乙醇水提取物3份；苦参50wt％乙醇水提取物1份；醋酸洗必泰4份；金银花提取物3份；蒲公英提取物4份；薄荷提取物2份；冰片1份；聚乙二醇(聚乙二醇400和聚乙二醇3350的比例为30:70)3份；甘油5份；薄荷脑1份；月桂基两性醋酸钠13份。
其制备方法包容如下步骤：
步骤1)：取金银花、蒲公英、薄荷，捣碎后分别加入热水浸泡2小时，再进行搅拌热浸提，浸提温度为55℃，浸提时间为4h，料液重量比为1:8；热浸提后离心，收集上清液，分别将上清液浓缩，分别得到金银花提取物、蒲公提取物、薄荷提取物；
步骤2)：取百部、苦参捣碎，捣碎后用50wt％的乙醇水溶液进行提取，提取温度为60℃，提取时间为3h，料液重量比为1:8，提取后离心分离，将滤液真空薄膜蒸发，得到百部50wt％乙醇水提取物、苦参50wt％乙醇水提取物；
步骤3)：按重量份取百部50wt％乙醇水提取物、苦参50wt％乙醇水提取物、金银花水提取物、蒲公英水提取物、醋酸洗必泰、薄荷提取物、冰片、聚乙二醇、甘油、薄荷脑以及月桂基两性醋酸钠，将上述的各种提取物及其他辅料混合均匀，得到抗菌止痒中药膏剂。
实施例4
一种抗菌止痒中药膏剂，包括如下重量份的成分：百部50wt％乙醇水提取物8份；苦参50wt％乙醇水提取物2份；醋酸洗必泰8份；金银花提取物6份；蒲公英提取物9份；薄荷提取物5份；冰片3份；聚乙二醇(聚乙二醇400和聚乙二醇3350的比例为40:60)10份；甘油10份；薄荷脑3份；月桂基两性醋酸钠3份。
其制备方法包容如下步骤：
步骤1)：取金银花、蒲公英、薄荷，捣碎后分别加入热水浸泡2小时，再进行搅拌热浸提，浸提温度为58℃，浸提时间为4h，料液重量比为1:6；热浸提后离心，收集上清液，分别将上清液浓缩，分别得到金银花提取物、蒲公提取物、薄荷提取物；
步骤2)：取百部、苦参捣碎，捣碎后用50wt％的乙醇水溶液进行提取，提取温度为50℃，提取时间为4h，料液重量比为1:6，提取后离心分离，将滤液真空薄膜蒸发，得到百部50wt％乙醇水提取物、苦参50wt％乙醇水提取物；
步骤3)：按重量份取百部50wt％乙醇水提取物、苦参50wt％乙醇水提取物、金银花水提取物、蒲公英水提取物、醋酸洗必泰、薄荷提取物、冰片、聚乙二醇、甘油、薄荷脑以及月桂基两性醋酸钠，将上述的各种提取物及其他辅料混合均匀，得到抗菌止痒中药膏剂。
尽管本发明的实施方案已公开如上，但其并不仅仅限于说明书和实施方式中所列运用，它完全可以被适用于各种适合本发明的领域，对于熟悉本领域的人员而言，可容易地实现另外的修改，因此在不背离权利要求及等同范围所限定的一般概念下，本发明并不限于特定的细节。

Claims (7)

  1. 一种抗菌止痒中药膏剂，其特征在于，包括如下重量份的成分：百部50wt％乙醇水提取物4-10份；苦参50wt％乙醇水提取物1-3份；醋酸洗必泰1-10份；金银花提取物2-8份；蒲公英提取物3-8份；薄荷提取物3-8份；冰片0.5-3份；聚乙二醇2-15份；甘油3-15份；薄荷脑1-3份；月桂基两性醋酸钠0.5-3份。
  2. 如权利要求1所述的抗菌止痒中药膏剂，其特征在于，包括如下重量份的成分：百部50wt％乙醇水提取物3-8份；苦参50wt％乙醇水提取物1-2份；醋酸洗必泰4-8份；金银花提取物3-6份；蒲公英提取物4-9份；薄荷提取物2-5份；冰片1-3份；聚乙二醇3-10份；甘油5-10份；薄荷脑1-3份；月桂基两性醋酸钠1-3份。
  3. 如权利要求1或2所述的抗菌止痒中药膏剂，其特征在于，所述聚乙二醇是聚乙二醇400和聚乙二醇3350的混合物。
  4. 如权利要求3所述的抗菌止痒中药膏剂，其特征在于，所述聚乙二醇400和聚乙二醇3350的比例为20-50∶50-80。
  5. 如权利要求1所述的抗菌止痒中药膏剂的制备方法，其特征在于，包括如下步骤：
    步骤1)：取金银花、蒲公英、薄荷，捣碎后分别加入热水浸泡1-4小时，再进行搅拌热浸提，热浸提后离心，收集上清液，分别将上清液浓缩，分别得到金银花提取物、蒲公提取物、薄荷提取物；
    步骤2)：取百部、苦参捣碎，捣碎后用50wt％的乙醇水溶液进行提取，提取后离心分离，将滤液真空薄膜蒸发，得到百部50wt％乙醇水提取物、苦参50wt％ 乙醇水提取物；
    步骤3)：按重量份取百部50wt％乙醇水提取物、苦参50wt％乙醇水提取物、金银花水提取物、蒲公英水提取物、醋酸洗必泰、薄荷提取物、冰片、聚乙二醇、甘油、薄荷脑以及月桂基两性醋酸钠，将上述的各种提取物及其他辅料混合均匀，得到抗菌止痒中药膏剂。
  6. 如权利要求1所述抗菌止痒中药膏剂的制备方法，其特征在于，所述步骤1)中热水浸泡2h，浸提温度为50-60℃，浸提时间为3-5h，料液重量比为1:5-1:10。
  7. 如权利要求1所述抗菌止痒中药膏剂的制备方法，其特征在于，所述步骤2)提取温度为40-70℃，提取时间为2-5h，料液重量比为1:4-1:10。
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