WO2017200194A3 - Composition comprenant du diacétyle pour inhiber la croissance de cellules souches cancéreuses - Google Patents

Composition comprenant du diacétyle pour inhiber la croissance de cellules souches cancéreuses Download PDF

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Publication number
WO2017200194A3
WO2017200194A3 PCT/KR2017/002890 KR2017002890W WO2017200194A3 WO 2017200194 A3 WO2017200194 A3 WO 2017200194A3 KR 2017002890 W KR2017002890 W KR 2017002890W WO 2017200194 A3 WO2017200194 A3 WO 2017200194A3
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WO
WIPO (PCT)
Prior art keywords
diacetyl
cancer
composition
stem cells
breast cancer
Prior art date
Application number
PCT/KR2017/002890
Other languages
English (en)
Korean (ko)
Other versions
WO2017200194A2 (fr
Inventor
이동선
최학선
정동기
고영상
Original Assignee
이동선
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 이동선 filed Critical 이동선
Publication of WO2017200194A2 publication Critical patent/WO2017200194A2/fr
Publication of WO2017200194A3 publication Critical patent/WO2017200194A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/308—Foods, ingredients or supplements having a functional effect on health having an effect on cancer prevention
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nutrition Science (AREA)
  • Microbiology (AREA)
  • Birds (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Emergency Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne une composition comprenant du diacétyle ou un sel pharmaceutiquement acceptable de celui-ci en tant qu'ingrédient efficace pour inhiber la croissance de cellules souches cancéreuses, une composition aromatisante comprenant du diacétyle ou un sel pharmaceutiquement acceptable de celui-ci en tant qu'ingrédient efficace, une composition pharmaceutique pour supprimer la métastase du cancer ou pour traiter ou prévenir le cancer, contenant la composition, et une composition alimentaire. Le diacétyle de la présente invention supprime la croissance des cellules de cancer du sein et de cancer colorectal et inhibe la formation des cellules souches du cancer du sein et du cancer colorectal. En outre, on observe que le diacétyle est inhibiteur de l'expression des gènes d'auto-renouvellement, tels que Nanog, Sox2, Oct4 et CD44, qui sont connus pour être exprimés de manière caractéristique dans les cellules souches du cancer du sein, et la production d'IL-6 et d'IL-8, qui sont connues pour être impliquées dans la formation de mammosphères de cellules souches du cancer du sein, et pour interférer avec la voie de signalisation STAT3. En outre, on a découvert que le diacétyle supprime la production d'IL-8, qui est connue pour être impliquée dans la formation de sphères tumorales dans les cellules souches du cancer colorectal, et pour interférer avec la voie de signalisation STAT3. En conséquence, le composé inhibe la croissance de cellules souches dans des cancers tels que le cancer du sein et le cancer colorectal et la croissance des cancers, et peut donc être appliqué au traitement d'un cancer, tel que le cancer du sein et le cancer colorectal.
PCT/KR2017/002890 2016-05-18 2017-03-17 Composition comprenant du diacétyle pour inhiber la croissance de cellules souches cancéreuses WO2017200194A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20160060811 2016-05-18
KR10-2016-0060811 2016-05-18

Publications (2)

Publication Number Publication Date
WO2017200194A2 WO2017200194A2 (fr) 2017-11-23
WO2017200194A3 true WO2017200194A3 (fr) 2018-09-07

Family

ID=60325325

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2017/002890 WO2017200194A2 (fr) 2016-05-18 2017-03-17 Composition comprenant du diacétyle pour inhiber la croissance de cellules souches cancéreuses

Country Status (2)

Country Link
KR (1) KR101907151B1 (fr)
WO (1) WO2017200194A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017096298A1 (fr) 2015-12-04 2017-06-08 Regents Of The University Of California Inhibiteurs d'histone désacétylase

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070259956A1 (en) * 2003-05-09 2007-11-08 Thompson Craig B Compositions and methods for treating cancer
CN101085949A (zh) * 2007-06-18 2007-12-12 大连工业大学 树莓啤酒及其酿造方法
WO2011015589A1 (fr) * 2009-08-03 2011-02-10 Institut Clinident Procédé d'évaluation du risque de cancer chez l'homme
WO2015088039A1 (fr) * 2013-12-10 2015-06-18 国立大学法人九州大学 Méthode de détection d'un cancer utilisant le sens de l'odorat des nématodes

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4512265B2 (ja) 2000-12-26 2010-07-28 株式会社ヤクルト本社 乳酸菌培養上清およびその製造方法並びに当該上清を利用する皮膚外用剤
KR101289033B1 (ko) 2011-07-04 2013-07-23 한양대학교 산학협력단 암 줄기세포 성장 억제용 조성물
KR101670590B1 (ko) * 2014-05-26 2016-10-28 숙명여자대학교산학협력단 Ｅｒｋ 신호활성 억제제를 유효성분으로 함유하는 암 줄기세포 성장 억제용 조성물
KR101724541B1 (ko) * 2016-04-29 2017-04-07 제주대학교 산학협력단 페닐아세트알데히드를 포함하는, 유방암 줄기세포 성장 억제용 조성물

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070259956A1 (en) * 2003-05-09 2007-11-08 Thompson Craig B Compositions and methods for treating cancer
CN101085949A (zh) * 2007-06-18 2007-12-12 大连工业大学 树莓啤酒及其酿造方法
WO2011015589A1 (fr) * 2009-08-03 2011-02-10 Institut Clinident Procédé d'évaluation du risque de cancer chez l'homme
WO2015088039A1 (fr) * 2013-12-10 2015-06-18 国立大学法人九州大学 Méthode de détection d'un cancer utilisant le sens de l'odorat des nématodes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KIM, DONG-WOOK ET AL.: "The Effects of Culture Conditions on the Diacetyl Production by Lactic Acid Bacteria", JOURNAL OF KOREA SOCIETY OF FOOD SCIENCE AND TECHNOLOGY, vol. 21, no. 1, 1989, pages 120 - 126 *

Also Published As

Publication number Publication date
KR20170130278A (ko) 2017-11-28
WO2017200194A2 (fr) 2017-11-23
KR101907151B1 (ko) 2018-10-12

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