WO2017150537A1 - 抗菌性生体内埋込用器具 - Google Patents
抗菌性生体内埋込用器具 Download PDFInfo
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- WO2017150537A1 WO2017150537A1 PCT/JP2017/007813 JP2017007813W WO2017150537A1 WO 2017150537 A1 WO2017150537 A1 WO 2017150537A1 JP 2017007813 W JP2017007813 W JP 2017007813W WO 2017150537 A1 WO2017150537 A1 WO 2017150537A1
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- antibacterial
- implantable device
- cobalt
- vivo implantable
- vivo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/06—Titanium or titanium alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
- A61L27/306—Other specific inorganic materials not covered by A61L27/303 - A61L27/32
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/02—Inorganic materials
- A61L31/028—Other inorganic materials not covered by A61L31/022 - A61L31/026
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/082—Inorganic materials
- A61L31/088—Other specific inorganic materials not covered by A61L31/084 or A61L31/086
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
Definitions
- the present invention relates to an in-vivo implant device, and more particularly to an in-vivo implant device that exhibits antibacterial properties when implanted and used in the living body.
- the insulator has a body, and when implanted, the current flowing from the first terminal without forming a circuit including conductive body tissue or body fluid located adjacent to an outer surface of the implant system is allowed to flow through the first terminal.
- Patent Document 1 A medical implant system that prevents the terminal 2 from being reached has been proposed (Patent Document 1).
- antibacterial metals include silver, copper, both silver and copper, both silver and cadmium, or a combination of silver, copper, and cadmium.
- external power supply equipment and terminals are necessary in addition to the implant body, and treatment or external operation is necessary to impart antibacterial properties. Further improvements are required from the viewpoint of reducing patient load.
- An object of the present invention is to provide an in vivo implantable device that can exhibit antibacterial properties simply by being implanted in the living body in order to reduce the burden on the patient.
- An in-vivo implantable device comprising a rod containing a second material and a ring containing a first material fitted to at least a part of the periphery of the rod, At least the surface of the first material comprises an antibacterial metal; At least the surface of the second material is an antibacterial metal that is noble than the first material, An electrical circuit is configured between the first material and the second material when used by being implanted in a living body, In the presence of the electrolyte, the antibacterial metal ions are eluted from the first material, An antibacterial in vivo implantable device characterized in that the surface and / or vicinity of the first material is antibacterial.
- the cobalt group-containing alloy includes cobalt: 29 to 69 mass%.
- the antibacterial in vivo implantable device according to [3] or [4], wherein the cobalt group-containing alloy is a cobalt chromium alloy.
- the in-vivo implant device of the present invention is once implanted in the living body and can exhibit antibacterial properties without any external operation or treatment, the burden on the patient can be remarkably reduced.
- FIG. 1 It is a schematic explanatory drawing which shows the use condition of the antimicrobial in-vivo implantable device of this invention. It is the top view of (a) O type antibacterial ring of a 1st embodiment, (b) Side view, and (c) Sectional drawing. It is the top view of (a) O type antibacterial ring of a 2nd embodiment, (b) Side view, and (c) Sectional drawing. It is the top view of (a) C type antibacterial ring of a 1st embodiment, (b) Side view, and (c) Cross section. It is the top view of (a) C type antibacterial ring of a 2nd embodiment, (b) Side view, and (c) Cross-sectional view.
- the antibacterial in vivo implant device of the present invention is an in vivo implant device composed of a first material and a second material, wherein at least a surface of the first material contains an antibacterial metal, At least the surface of the second material is an antibacterial metal that is more noble than the first material, and an electric circuit is formed between the first material and the second material when used in a living body.
- the antibacterial metal ions are eluted from the first material in the presence of an electrolyte, and the surface and / or vicinity of the first material is made antibacterial.
- the antibacterial in vivo implantable device of the present invention comprises at least two kinds of materials, and an electric circuit is formed by short-circuiting only by bringing these two kinds of materials into contact with each other in vivo.
- the first material contains at least one antibacterial metal of cobalt, silver, zinc, copper, tungsten, magnesium, nickel, and phosphorus, and is preferably a cobalt group-containing alloy. More preferably, the cobalt group-containing alloy contains cobalt: 29 to 69 mass%. More preferably, the cobalt group-containing alloy is a cobalt chromium alloy containing chromium: 18 to 30 mass%.
- the second material is preferably titanium or a titanium group-containing alloy. More preferably, the titanium or the titanium alloy contains titanium: 68 to 100 mass%.
- Cobalt ions are eluted from one material in the range of 7 nmol / l to 81 ⁇ mol / l, providing good antibacterial properties.
- FIG. 1 is a schematic explanatory view showing a use state of an antibacterial in vivo implantable device (ring) of the present invention.
- FIG. 1 shows a rod 2 laid between two screws 1 embedded in vertebrae (pedicles), respectively, and an antibacterial ring 3 fitted around the rod 2. Yes.
- FIG. 2 shows (a) a top view of the O-type antibacterial ring 3 of the first embodiment, (b) a side view, and (c) a sectional view.
- the O-type antibacterial ring 3 is used by being fitted to the rod 2.
- the O-type antibacterial ring 3 shown in FIG. 2 is entirely composed of a first material.
- FIG. 3 shows (a) a top view of the O-type antibacterial ring 3 of the second embodiment, (b) a side view, and (c) a sectional view.
- the O-type antibacterial ring 3 shown in FIG. 3 includes a solid region 3a made of a first material and a porous region 3b made of a first material or a second material.
- the porous region 3b is a region in which fibers containing the first material or the second material are entangled or joined, or a region containing a sintered body of powder particles of the first material or the second material. .
- the porous region 3b is laminated so as to coat the surface of the solid region 3a.
- compression molding method In order to laminate the porous region and the solid region, compression molding method, sintering method, diffusion bonding method, additive manufacturing method using electron beam or laser, etc., metal powder injection molding method (Metal Injection) Molding), spark plasma sintering (Spark Plasma Sintering), and combinations thereof can be suitably used.
- metal powder injection molding method Metal Injection
- spark plasma sintering spark Plasma Sintering
- the antibacterial property improves as the surface area ratio of the second material increases.
- FIG. 4 shows (a) a top view of the C-type antibacterial ring 3 of the first embodiment, (b) a side view and (c) a sectional view.
- the C-type antibacterial ring 3 is used by being fitted into the rod 2.
- the C-type antibacterial ring 3 shown in FIG. 4 is entirely composed of a first material.
- FIG. 5 shows (a) a top view of the C-type antibacterial ring 3 of the second embodiment, (b) a side view, and (c) a sectional view.
- the C-type antibacterial ring 3 shown in FIG. 5 is similar to the O-type antibacterial ring shown in FIG. 3 from the solid region 3a made of the first material and the first material or the second material.
- the porous region 3b is laminated so as to coat the surface of the solid region 3a.
- Example 1 (Test piece preparation) Table 1 shows various biocompatible titanium alloys (titanium content: 88 to 91 mass%) and biocompatible cobalt chromium alloys (cobalt content: 58 to 69 mass%, chromium content: 26 to 30 mass%). It was processed into a coin-shaped test piece having an area of 3 mm in thickness (only the titanium alloy of test piece number 3 was a flat plate shape), laminated in various combinations shown in Table 1, and short-circuited.
- test piece shown in Table 1 was placed in a Petri dish, and 40 ⁇ l of Staphylococcus aureus (NBRC12732) suspended in a normal bouillon medium (1/100) was dropped. A polyethylene film was placed on the dropped test bacterial solution and cultured at 35 ° C. for 24 hours, and then the cells were washed out from the test piece. The obtained washing solution is serially diluted with a 10-fold dilution series, subjected to an agar plate culture method and cultured at 35 ° C. for 24 hours, and the viable cell count is calculated from the number of colonies formed (CFU: Colony Forming Unit) did.
- the antibacterial activity value was defined as the difference between the logarithmic values of the viable cell count (Nc) on the control polyethylene test piece after 24 hours contact and the viable count (N) of each test piece.
- Table 2 shows the viable count and antibacterial activity value of each test piece. When the antibacterial activity value was 2.0 or more, it was judged that there was an antibacterial effect. As the area ratio (surface area of the titanium alloy test piece / surface area of the cobalt chromium alloy test piece) increased, the viable cell count decreased (the antibacterial activity value increased).
- Example 2 (Test piece preparation) An in vivo implantable device (designed with an area ratio of titanium alloy to cobalt chromium alloy of 0.89) made of a titanium alloy and a cobalt chromium alloy was prepared (in vivo implantable device 1). As a comparative example, an in vivo implantable device made of only a titanium alloy having exactly the same shape was also produced (in vivo implantable device 2).
- a device for implantation in a living body was installed in a polypropylene tube and immersed in 1 ml of Staphylococcus aureus (NBRC12732) suspended in a normal bouillon medium (1/100). The solution was collected after culturing at 35 ° C. for 24 hours. The obtained recovered solution is serially diluted with a 10-fold dilution series, subjected to agar plate culture method and cultured at 35 ° C. for 24 hours, and the number of viable bacteria is obtained from the number of colonies formed (CFU: Colony Forming Unit). It was.
- CFU Colony Forming Unit
- Table 4 shows the viable count and antibacterial activity value of each in vivo implantable device.
- the in vivo implantable device 1 in which the area ratio of the titanium alloy and the cobalt chromium alloy is appropriately designed has a significantly reduced viable count.
- the in vivo implantable instrument 2 made of only a titanium alloy no decrease in the number of viable bacteria was observed.
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Abstract
Description
[1]第二の材料を含むロッドと、当該ロッドの周囲の少なくとも一部に嵌合する第一の材料を含むリングと、から構成される生体内埋込用器具であって、
第一の材料の少なくとも表面は抗菌性金属を含み、
第二の材料の少なくとも表面は第一の材料より貴である抗菌性金属であり、
生体内に埋め込んで使用される際に当該第一の材料と当該第二の材料との間で電気回路が構成され、
電解質存在下において当該第一の材料から当該抗菌性金属のイオンが溶出し、
当該第一の材料表面及び/又は近傍を抗菌性とすることを特徴とする抗菌性生体内埋込用器具。
[2]前記第一の材料は、コバルト、銀、亜鉛、銅、タングステン、マグネシウム、ニッケル、リンの少なくともいずれか一つの抗菌性金属を含むことを特徴とする[1]の抗菌性生体内埋込用器具。
[3]前記第一の材料は、コバルト基含有合金である[1]又は[2]の抗菌性生体内埋込用器具。
[4]前記コバルト基含有合金は、コバルト:29~69mass%を含む、[3]に記載の抗菌性生体内埋込用器具。
[5]前記コバルト基含有合金が、コバルトクロム合金である[3]又は[4]に記載の抗菌性生体内埋込用器具。
[6]前記コバルトクロム合金は、クロム:18~30mass%を含む、[4]に記載の抗菌性生体内埋込用器具。
[7]前記第二の材料は、チタンあるいはチタン基含有合金である[1]~[6]のいずれか1に記載の抗菌性生体内埋込用器具。
[8]前記チタンあるいはチタン合金は、チタン:68~100mass%を含む、[7]に記載の抗菌性生体内埋込用器具。
[9]前記第一の材料の表面積と第二の材料の表面積との比率が、第二の材料/第一の材料=0.2~10.8の範囲にあることを特徴とする[1]~[8]のいずれか1に記載の抗菌性生体内埋込用器具。
[10]前記第一の材料からコバルトイオンが7nmol/l~81μmol/lの範囲で溶出することを特徴とする[1]~[9]の抗菌性生体内埋込用器具。
[11]前記第一の材料を含む繊維が絡合あるいは接合してなる多孔質領域及び/又は前記第二の材料を含む繊維が絡合あるいは接合してなる多孔質領域を含む、[1]~[10]のいずれか1に記載の抗菌性生体内埋込用器具。
[12]前記第一の材料を含む繊維が絡合あるいは接合してなる多孔質構造体及び/又は前記第二の材料を含む繊維が絡合あるいは接合してなる多孔質構造体を含む、[11]に記載の抗菌性生体内埋込用器具。
[13]前記第一の材料又は前記第二の材料の粉末粒子の焼結部を有する、[1]~[10]のいずれか1に記載の抗菌性生体内埋込用器具。
[14]前記第一の材料又は前記第二の材料の粉末粒子の焼結体を有する、[13]に記載の抗菌性生体内埋込用器具。
(試験片作製)
市販の生体適合性チタン合金(チタン含有量:88~91mass%)及び生体適合性コバルトクロム合金(コバルト含有量:58~69mass%、クロム含有量:26~30mass%)を表1に示す種々の面積を有する厚さ3mmのコイン形状の試験片(試験片番号3のチタン合金のみ平板形状)に加工し、表1に示す種々の組合せで積層させて短絡させた。比較対象として、厚さ1mmの平板形状のポリエチレン製試験片(対照)、厚さ3mmのコイン形状のコバルトクロム合金製試験片(比較1)及び厚さ3mmのコイン形状のチタン合金性試験片(比較2)も同様に作製した。
JIS Z2801抗菌加工製品-抗菌性試験方法・抗菌効果を参考に抗菌性評価を行った。
(試験片作製)
チタン合金及びコバルトクロム合金からなる生体内埋込用器具(コバルトクロム合金に対するチタン合金の面積比を0.89に設計した)を作製した(生体内埋込用器具1)。比較例として、全く同じ形状のチタン合金のみからなる生体内埋込用器具も同様に作製した(生体内埋込用器具2)。
ポリプロピレン製チューブに生体内埋込用器具を設置し、普通ブイヨン培地(1/100)に懸濁させたStaphylococcus aureus(NBRC12732)1mlに浸漬した。35°Cにて24時間培養後に溶液を回収した。得られた回収液を10倍希釈系列で段階希釈し、寒天平板培養法に供して35°Cにて24時間培養し、形成されたコロニー数(CFU: Colony Forming Unit)から生菌数を求めた。
Claims (14)
- 第二の材料を含むロッドと、当該ロッドの周囲の少なくとも一部に嵌合する第一の材料を含むリングと、から構成される生体内埋込用器具であって、
第一の材料の少なくとも表面は抗菌性金属を含み、
第二の材料の少なくとも表面は第一の材料より貴であり、
生体内に埋め込んで使用される際に当該第一の材料と当該第二の材料との間で電気回路が構成され、
電解質存在下において当該第一の材料から当該抗菌性金属のイオンが溶出し、
当該第一の材料表面及び/又は近傍を抗菌性とすることを特徴とする抗菌性生体内埋込用器具。 - 前記第一の材料は、コバルト、銀、亜鉛、銅、タングステン、マグネシウム、ニッケル、リンの少なくともいずれか一つの抗菌性金属を含むことを特徴とする請求項1の抗菌性生体内埋込用器具。
- 前記第一の材料は、コバルト基含有合金である請求項1又は2の抗菌性生体内埋込用器具。
- 前記コバルト基含有合金は、コバルト:29~69mass%を含む、請求項3に記載の抗菌性生体内埋込用器具。
- 前記コバルト基含有合金が、コバルトクロム合金である請求項3又は4に記載の抗菌性生体内埋込用器具。
- 前記コバルトクロム合金は、クロム:18~30mass%を含む、請求項4に記載の抗菌性生体内埋込用器具。
- 前記第二の材料は、チタンあるいはチタン基含有合金である請求項1~6のいずれか1に記載の抗菌性生体内埋込用器具。
- 前記チタンあるいはチタン合金は、チタン:68~100mass%を含む、請求項7に記載の抗菌性生体内埋込用器具。
- 前記第一の材料の表面積と第二の材料の表面積との比率が、第二の材料/第一の材料=0.2~10.8の範囲にあることを特徴とする請求項1~8のいずれか1に記載の抗菌性生体内埋込用器具。
- 前記第一の材料からコバルトイオンが7nmol/l~81μmol/lの範囲で溶出することを特徴とする請求項1~9の抗菌性生体内埋込用器具。
- 前記第一の材料を含む繊維が絡合あるいは接合してなる多孔質領域及び/又は前記第二の材料を含む繊維が絡合あるいは接合してなる多孔質領域を含む、請求項1~10のいずれか1に記載の抗菌性生体内埋込用器具。
- 前記第一の材料を含む繊維が絡合あるいは接合してなる多孔質構造体及び/又は前記第二の材料を含む繊維が絡合あるいは接合してなる多孔質構造体を含む、請求項11に記載の抗菌性生体内埋込用器具。
- 前記第一の材料又は前記第二の材料の粉末粒子の焼結部を有する、請求項1~10のいずれか1に記載の抗菌性生体内埋込用器具。
- 前記第一の材料又は前記第二の材料の粉末粒子の焼結体を有する、請求項13に記載の抗菌性生体内埋込用器具。
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EP17760003.8A EP3424466B1 (en) | 2016-02-29 | 2017-02-28 | Antibacterial apparatus for in-vivo implantation |
AU2017227295A AU2017227295A1 (en) | 2016-02-29 | 2017-02-28 | Antibacterial apparatus for in-vivo implantation |
CN201780012736.2A CN109069274B (zh) | 2016-02-29 | 2017-02-28 | 用于体内植入的抗菌装置 |
JP2018503333A JP6826584B2 (ja) | 2016-02-29 | 2017-02-28 | 抗菌性生体内埋込用器具 |
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JPWO2017150535A1 (ja) * | 2016-02-29 | 2019-01-24 | メドトロニックソファモアダネック株式会社 | 抗菌性生体内埋込用器具用セットスクリュー |
JPWO2017150532A1 (ja) * | 2016-02-29 | 2019-02-14 | メドトロニックソファモアダネック株式会社 | 抗菌性生体内埋込用器具 |
JPWO2017150542A1 (ja) * | 2016-02-29 | 2019-02-14 | メドトロニックソファモアダネック株式会社 | 抗菌性生体内埋込用器具 |
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EP3424466A4 (en) | 2019-11-06 |
EP3424466B1 (en) | 2022-06-15 |
JPWO2017150537A1 (ja) | 2019-01-24 |
EP3424466A1 (en) | 2019-01-09 |
JP6826584B2 (ja) | 2021-02-03 |
AU2017227295A1 (en) | 2018-08-16 |
CN109069274B (zh) | 2021-05-07 |
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