JP6783295B2 - 抗菌性生体内埋込用器具 - Google Patents
抗菌性生体内埋込用器具 Download PDFInfo
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- JP6783295B2 JP6783295B2 JP2018503335A JP2018503335A JP6783295B2 JP 6783295 B2 JP6783295 B2 JP 6783295B2 JP 2018503335 A JP2018503335 A JP 2018503335A JP 2018503335 A JP2018503335 A JP 2018503335A JP 6783295 B2 JP6783295 B2 JP 6783295B2
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- antibacterial
- implant device
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- vivo implant
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- 230000000844 anti-bacterial effect Effects 0.000 title claims description 85
- 238000001727 in vivo Methods 0.000 title claims description 54
- 239000007943 implant Substances 0.000 title claims description 32
- 239000000463 material Substances 0.000 claims description 124
- 229910052751 metal Inorganic materials 0.000 claims description 22
- 239000002184 metal Substances 0.000 claims description 22
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 claims description 18
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 14
- 229910001069 Ti alloy Inorganic materials 0.000 claims description 13
- 229910045601 alloy Inorganic materials 0.000 claims description 13
- 239000000956 alloy Substances 0.000 claims description 13
- 239000010936 titanium Substances 0.000 claims description 11
- 229910052719 titanium Inorganic materials 0.000 claims description 11
- WAIPAZQMEIHHTJ-UHFFFAOYSA-N [Cr].[Co] Chemical class [Cr].[Co] WAIPAZQMEIHHTJ-UHFFFAOYSA-N 0.000 claims description 10
- 229910017052 cobalt Inorganic materials 0.000 claims description 8
- 239000010941 cobalt Substances 0.000 claims description 8
- 229910021645 metal ion Inorganic materials 0.000 claims description 8
- 239000000843 powder Substances 0.000 claims description 8
- 239000007787 solid Substances 0.000 claims description 8
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 7
- 239000000835 fiber Substances 0.000 claims description 7
- 239000002245 particle Substances 0.000 claims description 7
- 229910052709 silver Inorganic materials 0.000 claims description 7
- 239000004332 silver Substances 0.000 claims description 7
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 6
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims description 6
- 239000010949 copper Substances 0.000 claims description 6
- 229910052802 copper Inorganic materials 0.000 claims description 6
- 239000003792 electrolyte Substances 0.000 claims description 6
- 238000002513 implantation Methods 0.000 claims description 5
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 claims description 4
- 229910052804 chromium Inorganic materials 0.000 claims description 4
- 239000011651 chromium Substances 0.000 claims description 4
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 3
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 3
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 3
- 229910001429 cobalt ion Inorganic materials 0.000 claims description 3
- XLJKHNWPARRRJB-UHFFFAOYSA-N cobalt(2+) Chemical compound [Co+2] XLJKHNWPARRRJB-UHFFFAOYSA-N 0.000 claims description 3
- 229910052749 magnesium Inorganic materials 0.000 claims description 3
- 239000011777 magnesium Substances 0.000 claims description 3
- 229910052759 nickel Inorganic materials 0.000 claims description 3
- 229910052698 phosphorus Inorganic materials 0.000 claims description 3
- 239000011574 phosphorus Substances 0.000 claims description 3
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 claims description 3
- 229910052721 tungsten Inorganic materials 0.000 claims description 3
- 239000010937 tungsten Substances 0.000 claims description 3
- 229910052725 zinc Inorganic materials 0.000 claims description 3
- 239000011701 zinc Substances 0.000 claims description 3
- 238000000034 method Methods 0.000 description 7
- 238000005245 sintering Methods 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 4
- -1 polyethylene Polymers 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 239000004698 Polyethylene Substances 0.000 description 3
- 238000010828 elution Methods 0.000 description 3
- 238000001746 injection moulding Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 229920000573 polyethylene Polymers 0.000 description 3
- 229920001817 Agar Polymers 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 229910052793 cadmium Inorganic materials 0.000 description 2
- BDOSMKKIYDKNTQ-UHFFFAOYSA-N cadmium atom Chemical compound [Cd] BDOSMKKIYDKNTQ-UHFFFAOYSA-N 0.000 description 2
- 238000000748 compression moulding Methods 0.000 description 2
- 238000012136 culture method Methods 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 238000010894 electron beam technology Methods 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000002490 spark plasma sintering Methods 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 239000000788 chromium alloy Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000012212 insulator Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 230000000399 orthopedic effect Effects 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/06—Titanium or titanium alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/80—Cortical plates, i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
- A61L27/306—Other specific inorganic materials not covered by A61L27/303 - A61L27/32
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/02—Inorganic materials
- A61L31/028—Other inorganic materials not covered by A61L31/022 - A61L31/026
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/082—Inorganic materials
- A61L31/088—Other specific inorganic materials not covered by A61L31/084 or A61L31/086
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/146—Porous materials, e.g. foams or sponges
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
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- Surgery (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Inorganic Chemistry (AREA)
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- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
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- Prostheses (AREA)
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Description
[1]第一の材料と第二の材料から構成される生体内埋込用器具であって、
第一の材料の少なくとも表面は抗菌性金属を含み、
第二の材料の少なくとも表面は第一の材料より貴である抗菌性金属であり、
生体内に埋め込んで使用される際に当該第一の材料と当該第二の材料との間で電気回路が構成され、
電解質存在下において当該第一の材料から抗菌性金属のイオンが溶出して、
当該第一の材料表面及び/又は近傍を抗菌性とすることを特徴とする抗菌性生体内埋込用器具。
[2]前記第一の材料は、コバルト、銀、亜鉛、銅、タングステン、マグネシウム、ニッケル、リンの少なくともいずれか一つの抗菌性金属を含むことを特徴とする[1]の抗菌性生体内埋込用器具。
[3]前記第一の材料は、コバルト基含有合金である[1]又は[2]の抗菌性生体内埋込用器具。
[4]前記コバルト基含有合金は、コバルト:29〜69mass%を含む、[3]に記載の抗菌性生体内埋込用器具。
[5]前記コバルト基含有合金が、コバルトクロム合金である[3]又は[4]に記載の抗菌性生体内埋込用器具。
[6]前記コバルトクロム合金は、クロム:18〜30mass%を含む、[5]に記載の抗菌性生体内埋込用器具。
[7]前記第二の材料は、チタンあるいはチタン基含有合金である[1]〜[6]のいずれか1に記載の抗菌性生体内埋込用器具。
[8]前記チタンあるいはチタン合金は、チタン:68〜100mass%を含む、[7]に記載の抗菌性生体内埋込用器具。
[9]前記第一の材料の表面積と第二の材料の表面積との比率が、第二の材料/第一の材料=0.2〜10.8の範囲にあることを特徴とする[1]〜[8]のいずれか1に記載の抗菌性生体内埋込用器具。
[10]前記第一の材料からコバルトイオンが7nmol/l〜81μmol/lの範囲で溶出することを特徴とする[2]〜[9]のいずれか1に記載の抗菌性生体内埋込用器具。
[11]前記抗菌性生体内埋込用器具はプレートであり、
プレートの本体が前記第二の材料を含み、
前記第一の材料をプレートの本体の少なくとも一部にコーティングしてなる、[1]〜[10]のいずれか1に記載の抗菌性生体内埋込用器具。
[12]前記抗菌性生体内埋込用器具はプレートであり、
前記第二の材料を含む繊維が絡合あるいは接合してなる多孔質構造体の上に、前記第一の材料を含む繊維が絡合あるいは接合してなる多孔質構造体が積層されている、[1]〜[10]のいずれか1に記載の抗菌性生体内埋込用器具。
[13]前記抗菌性生体内埋込用器具はプレートであり、
プレートの本体が前記第二の材料を含み、
前記第二の材料を含む中実部と、前記第二の材料を含む多孔質部とが積層されている、[1]〜[10]のいずれか1に記載の抗菌性生体内埋込用器具。
[14]前記抗菌性生体内埋込用器具はプレートであり、
プレートの本体が前記第二の材料を含み、
前記第二の材料の粉末粒子を含む多孔質部の上に、前記第一の材料を含む多孔質部が積層されている、[1]〜[10]のいずれか1に記載の抗菌性生体内埋込用器具。
(試験片作製)
市販の生体適合性チタン合金(チタン含有量:88〜91mass%)及び生体適合性コバルトクロム合金(コバルト含有量:58〜69mass%、クロム含有量:26〜30mass%)を表1に示す種々の面積を有する厚さ3mmのコイン形状の試験片(試験片番号3のチタン合金のみ平板形状)に加工し、表1に示す種々の組合せで積層させて短絡させた。比較対象として、厚さ1mmの平板形状のポリエチレン製試験片(対照)、厚さ3mmのコイン形状のコバルトクロム合金製試験片(比較1)及び厚さ3mmのコイン形状のチタン合金性試験片(比較2)も同様に作製した。
JIS Z2801抗菌加工製品−抗菌性試験方法・抗菌効果を参考に抗菌性評価を行った。
(試験片作製)
チタン合金及びコバルトクロム合金からなる生体内埋込用器具(コバルトクロム合金に対するチタン合金の面積比を0.89に設計した)を作製した(生体内埋込用器具1)。比較例として、全く同じ形状のチタン合金のみからなる生体内埋込用器具も同様に作製した(生体内埋込用器具2)。
ポリプロピレン製チューブに生体内埋込用器具を設置し、普通ブイヨン培地(1/100)に懸濁させたStaphylococcus aureus(NBRC12732)1mlに浸漬した。35°Cにて24時間培養後に溶液を回収した。得られた回収液を10倍希釈系列で段階希釈し、寒天平板培養法に供して35°Cにて24時間培養し、形成されたコロニー数(CFU: Colony Forming Unit)から生菌数を求めた。
Claims (12)
- 第一の材料と第二の材料から構成される生体内埋込用器具であって、
第一の材料の少なくとも表面は抗菌性金属を含み、
第二の材料の少なくとも表面は第一の材料より貴である抗菌性金属であり、
生体内に埋め込んで使用される際に当該第一の材料と当該第二の材料との間で電気回路が構成され、
電解質存在下において当該第一の材料から抗菌性金属のイオンが溶出し、
当該第一の材料表面及び/又は近傍を抗菌性とすること、及び
前記抗菌性生体内埋込用器具はプレートであり、
前記第二の材料を含む繊維が絡合あるいは接合してなる多孔質構造体の上に、前記第一の材料を含む繊維が絡合あるいは接合してなる多孔質構造体が積層されている
を特徴とする抗菌性生体内埋込用器具。 - 第一の材料と第二の材料から構成される生体内埋込用器具であって、
第一の材料の少なくとも表面は抗菌性金属を含み、
第二の材料の少なくとも表面は第一の材料より貴である抗菌性金属であり、
生体内に埋め込んで使用される際に当該第一の材料と当該第二の材料との間で電気回路が構成され、
電解質存在下において当該第一の材料から抗菌性金属のイオンが溶出し、
当該第一の材料表面及び/又は近傍を抗菌性とすること、及び
前記抗菌性生体内埋込用器具はプレートであり、
プレートの本体が前記第二の材料を含み、
前記第二の材料を含む中実部と、前記第二の材料を含む多孔質部とが積層されている
ことを特徴とする抗菌性生体内埋込用器具。 - 第一の材料と第二の材料から構成される生体内埋込用器具であって、
第一の材料の少なくとも表面は抗菌性金属を含み、
第二の材料の少なくとも表面は第一の材料より貴である抗菌性金属であり、
生体内に埋め込んで使用される際に当該第一の材料と当該第二の材料との間で電気回路が構成され、
電解質存在下において当該第一の材料から抗菌性金属のイオンが溶出し、
当該第一の材料表面及び/又は近傍を抗菌性とすること、及び
前記抗菌性生体内埋込用器具はプレートであり、
プレートの本体が前記第二の材料を含み、
前記第二の材料の粉末粒子を含む多孔質部の上に、前記第一の材料を含む多孔質部が積層されている
ことを特徴とする抗菌性生体内埋込用器具。 - 前記第一の材料は、コバルト、銀、亜鉛、銅、タングステン、マグネシウム、ニッケル、リンの少なくともいずれか一つの抗菌性金属を含むことを特徴とする請求項1〜3のいずれか1に記載の抗菌性生体内埋込用器具。
- 前記第一の材料は、コバルト基含有合金である請求項1〜4のいずれか1に記載の抗菌性生体内埋込用器具。
- 前記コバルト基含有合金は、コバルト:29〜69mass%を含む、請求項5に記載の抗菌性生体内埋込用器具。
- 前記コバルト基含有合金が、コバルトクロム合金である請求項5又は6に記載の抗菌性生体内埋込用器具。
- 前記コバルトクロム合金は、クロム:18〜30mass%を含む、請求項7に記載の抗菌性生体内埋込用器具。
- 前記第二の材料は、チタンあるいはチタン基含有合金である請求項1〜8のいずれか1に記載の抗菌性生体内埋込用器具。
- 前記チタンあるいはチタン合金は、チタン:68〜100mass%を含む、請求項9に記載の抗菌性生体内埋込用器具。
- 前記第一の材料の表面積と第二の材料の表面積との比率が、第二の材料/第一の材料=0.2〜10.8の範囲にあることを特徴とする請求項1〜10のいずれか1に記載の抗菌性生体内埋込用器具。
- 前記第一の材料からコバルトイオンが7nmol/l〜81μmol/lの範囲で溶出することを特徴とする請求項4〜11のいずれか1に記載の抗菌性生体内埋込用器具。
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PCT/JP2017/007822 WO2017150542A1 (ja) | 2016-02-29 | 2017-02-28 | 抗菌性生体内埋込用器具 |
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JP (1) | JP6783295B2 (ja) |
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CN109069189B (zh) * | 2016-02-29 | 2021-05-25 | 美敦力索发摩尔丹耐克有限公司 | 抗微生物的体内植入装置 |
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US4476590A (en) * | 1980-03-27 | 1984-10-16 | National Research Development Corporation | Antimicrobial surgical implants |
US4886505A (en) * | 1985-06-07 | 1989-12-12 | Becton, Dickinson And Company | Antimicrobial surfaces and inhibition of microorganism growth thereby |
WO2000045724A1 (de) * | 1999-02-04 | 2000-08-10 | Synthes Ag Chur | Knochenschraube |
US20060004431A1 (en) * | 2004-07-01 | 2006-01-05 | Fuller Thomas A | Prophylactic bactericidal implant |
US8927004B1 (en) * | 2014-06-11 | 2015-01-06 | Silver Bullet Therapeutics, Inc. | Bioabsorbable substrates and systems that controllably release antimicrobial metal ions |
CN101791436B (zh) * | 2010-04-15 | 2014-04-16 | 四川大学 | 具有多孔磷酸钙-壳聚糖复合涂层的生物医用材料 |
EP2382960A1 (de) * | 2010-04-19 | 2011-11-02 | DERU GmbH Entwicklung von medizinischen Produkten | Implantat mit antimikrobieller Beschichtung |
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EP3424450B1 (en) * | 2016-02-29 | 2021-02-17 | Medtronic Sofamor Danek, Co., Ltd. | Set screw for antibacterial device to be implanted in vivo |
EP3424466B1 (en) * | 2016-02-29 | 2022-06-15 | Medtronic Sofamor Danek, Co., Ltd. | Antibacterial apparatus for in-vivo implantation |
CN109069189B (zh) * | 2016-02-29 | 2021-05-25 | 美敦力索发摩尔丹耐克有限公司 | 抗微生物的体内植入装置 |
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CN109152597A (zh) | 2019-01-04 |
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CN109152597B (zh) | 2021-05-07 |
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