WO2017148183A1

WO2017148183A1 - Compound traditional chinese medicine composition containing gynostemma pentaphyllum and preparation method thereof

Info

Publication number: WO2017148183A1
Application number: PCT/CN2016/106194
Authority: WO
Inventors: 谢其润; 张钊; 王少可; 徐景瑞; 田宏为; 张宛钰
Original assignee: 谢其润; 张钊
Priority date: 2016-02-29
Filing date: 2016-11-17
Publication date: 2017-09-08
Also published as: CN105663245A; ZA201805663B

Abstract

Disclosed are a compound traditional Chinese medicine composition containing gynostemma pentaphyllum and a preparation method thereof. The compound traditional Chinese medicine composition containing gynostemma pentaphyllum is made of gynostemma pentaphyllum, eucommia ulmoides leaves, frost mulberry leaves and pueraria mirifica powder as raw materials mixed together, and by weight percentage is 30-60% gynostemma pentaphyllum, 15-35% eucommia ulmoides leaves, 15- 35% frost mulberry leaves, and 5- 15% pueraria mirifica powder. The gynostemma pentaphyllum is formed of diploid gynostemma pentaphyllum leaves and tetraploid gynostemma pentaphyllum leaves by mixing in proportion. The compound traditional Chinese medicine composition is mainly used for the prevention and treatment of hyperlipoidemia, hypertension, hyperglycemia, fatty liver and so on, and also has many effects in anti-aging, prevention of various tumours, cardiovascular and cerebrovascular diseases and insomnia, amnesia, and overfatigue.

Description

Compound Chinese medicine composition containing Gynostemma pentaphyllum and preparation method thereof

Technical field

The invention belongs to the technical field of Gynostemma pentaphyllum, and particularly relates to a compound Chinese medicine composition containing Gynostemma pentaphyllum and a preparation method thereof.

Background technique

Hyperlipidemia, high blood pressure, and high blood sugar, commonly known as "three highs", are major problems affecting human health in China. There are hundreds of millions of people who have such problems in the country, and they are still growing year by year. This big problem is also prevalent in many developed countries in the world, and it is also a difficult problem in the medical field. "Three highs" are the source of many diseases and sub-health of human beings. With the development and deterioration of the "three highs", a series of diseases and complications will be triggered, which will seriously affect human health and even life.

At present, the medical profession is mainly based on western medicine for the prevention and treatment of "three highs". These drugs need to be taken for a long time or even for life, which is not only expensive but also has certain side effects. The ideal means of preventing and treating "three highs" should be early prevention and early intervention, with the comprehensive formula of health care plants as the main formula, and with good living habits. This is not only safe and effective, it has no side effects, and it can make people healthier through these beneficial plants.

Summary of the invention

In order to solve the above problems, the present invention provides a compound traditional Chinese medicine composition containing Gynostemma pentaphyllum, which is compatible with traditional Chinese medicines such as frosted mulberry leaves, Eucommia ulmoides leaves, and Kudzu root powder. The dirt, garbage and toxins on the inner wall of the liquid make the blood pass through the blood vessels, so that the blood vessels of the heart, brain, kidney, liver and various organs are softened, and the aging cells are cleared from the human body, so that the self-regulation of the human body can be restored. normal.

The Gynostemma Pentaphyllum is a perennial grass vine of the genus Gynostemma. There are 16 kinds of 3 subspecies in the world, 11 species and 1 subspecies in China, and 6 subspecies in Pingli (short stalk, long stalk, scutellaria, white hair, light leaf, sweet taste, hazelnut). Gynostemma pentaphyllum is mainly distributed in the south of the Qinling Mountains and in the Yangtze River Basin. Xishuang wet, scattered light, humus, the bottom of the rock between 200-1500 meters, the edge of the ditch, the environment under the forest. The main components of Gynostemma pentaphyllum are saponins, flavonoids, polysaccharides and trace elements such as zinc, selenium, iron, calcium and magnesium, vitamins A and B. It has the functions of regulating human body physiology, enhancing human immunity, counteracting glucocorticoid side effects, anti-oxidation and blood fat reduction.

There are many different species and hybrids of Gynostemma pentaphyllum (originally domesticated from wild species), and there are also different ploidy bodies (2X, 4X, 6X...) in nature. There are great differences in biological activity functions and active ingredients between different species and between different ploidy bodies. The difference between different places of origin is also very large, especially saponins, polyphenols, flavonoids and trace element selenium, etc., there are great differences. According to our analysis in the US laboratory, the different active ingredients of Gynostemma pentaphyllum produced in different regions of China and the world are not only very different, but also there is no single Gynostemma pentaphyllum which is the best in all major active ingredients. . Among all the samples analyzed, the diploid Gynostemma pentaphyllum in Pingli County, Shaanxi Province, analyzed the highest levels of polyphenols and flavonoids, while the tetraploid Gynostemma saponins and selenium content were the highest among all tested samples. Ok, its total saponin content averages 8.5%. Moreover, in different parts of the plant, regardless of diploid or tetraploid, the active ingredients of the leaves of the plants are most desirable. Combined The formula of Gynostemma pentaphyllum (2X+4X) can effectively lower cholesterol, thereby lowering blood fat, softening blood vessels, promoting cardiovascular function, thereby regulating blood pressure, and its effective active ingredients can also regulate blood sugar. Our compatibility formula has added several kinds of Chinese herbal medicines (eudox leaves, frost mulberry leaves, puerarin, etc.) which are also used as health foods, so that the overall effect on conditioning three high is further strengthened. If it can be taken frequently, it can not only regulate the three highs. It can also promote the health of the internal organs, and there are no side effects.

The Eucommia ulmoides leaves can enter the liver and tonify the kidneys, and replenish the essence. Studies have shown that Eucommia ulmoides has isolated 27 kinds of lignan compounds, of which rosinol diglucoside can effectively reduce blood pressure has also been proved by experiments at home and abroad, and five kinds of flavonoids such as eucommia ulmoides have been measured (regulating blood sugar, regulating Vascular function, etc., arachidin (central nervous decompression), and chlorogenic acid (inhibiting enzymes that control sugar synthesis in the body such as glucose-6-glucose, α-glucose), etc., but have solved the three high problems. efficacy.

The frost mulberry (freeze-dried mulberry leaves) retains the polysaccharides, flavonoids and alkaloids DNJ components in the mulberry leaves to the greatest extent, and has various health effects such as lowering blood fat, lowering blood sugar, lowering blood pressure, and delaying aging. It has an adjuvant treatment effect on patients with diabetes, hypertension and hyperlipidemia.

The pueraria root has the functions of clearing heat and reducing fire, nourishing yin and nourishing yang, promoting thirst and thirst, and appetizing for eating. The Ministry of Health also lists it as a food and health care product, puerarin, daidzin, isoflavones and various kinds in puerarin. Minerals, vitamins and trace elements (especially selenium) have a good effect on reducing fat, reducing blood pressure, regulating blood sugar and relieving alcohol, nourishing the stomach and protecting the liver, and can also help the human body to solve problems such as spleen deficiency, yin deficiency and thirst. .

In summary, two types of Gynostemma pentaphyllum (2X, 4X), combined with the above three traditional herbs to form the basic formula of our products, and the different active ingredients of these materials also benefit Zhang, the formation of complementarity, supplemented by appropriate Chinese medicine health foods, can form the basic principle of our "three high prevention" problem.

In order to achieve the above object, the technical solution adopted by the present invention is:

A compound Chinese medicine composition containing Gynostemma pentaphyllum, characterized in that the compound Chinese medicine composition containing Gynostemma pentaphyllum is prepared by mixing Gynostemma pentaphyllum, Eucommia ulmoides leaves, Frost mulberry leaves and Pueraria lobata powder as raw materials, in parts by mass: Gynostemma 30 ~60%, eucommia leaves 15 to 35%, frost mulberry leaves 15 to 35%, and Pueraria lobata powder 5 to 15%.

Further, the compound Chinese herbal composition containing Gynostemma pentaphyllum is prepared by mixing the following raw materials in parts by mass: 50 to 60% of Gynostemma pentaphyllum, 15 to 25% of Eucommia ulmoides, 15 to 25% of mulberry leaves, and 8 to 12 of Pueraria lobata. %.

Further, each raw material of the compound Chinese herbal medicine composition containing Gynostemma pentaphyllum is preferably 60 parts by weight of Gynostemma pentaphyllum, 15% of Eucommia ulmoides, 15% of mulberry leaves, and 10% of Pueraria lobata powder.

Further, the Gynostemma pentaphyllum is a mixture of diploid Gynostemma pentaphyllum leaves and tetraploid Gynostemma peninsula leaves.

Further, the diploid Gynostemma pentaphyllum leaves are in parts by mass: tetraploid Gynostemma pentaphyllum leaves = 2:3 to 3:2. Preferably, the diploid Gynostemma pentaphyllum leaves: tetraploid Gynostemma pentaphyllum leaves = 1:1.

Further, the compound Chinese herbal composition containing Gynostemma pentaphyllum is made into an instant powder or granule.

Another object of the present invention is to provide a preparation method of the compound Chinese herbal medicine composition containing Gynostemma pentaphyllum, comprising the following steps: 1) washing the harvested Gynostemma pentaphyllum leaves, Eucommia ulmoides leaves, and frost mulberry leaves, and drying at 60-80 ° C. Dry, dry raw material moisture content is controlled within 7%; 2) The dried raw materials are pulverized, proportioned, mixed, and granulated according to the formula; 3) placed in a dry heat sterilizing cabinet for sterilization and drying, the water content is controlled within 4%; 4) according to the dosage In a small package, store in a cool dry place.

The invention is compatible with traditional Chinese medicines such as frosted mulberry leaves, eucommia leaves and pueraria powder, and removes dirt, garbage and toxins from the inner wall of the blood, so that the blood can pass through the blood vessels, and the heart, brain, kidney, liver and organs are The blood vessels are softened, so that the aging cells are cleared from the human body, and the self-regulation of the human body is restored to normal. The reasonable Gynostemma formula (2X+4X) can effectively lower cholesterol, thereby lowering blood fat, softening blood vessels, promoting cardiovascular function, thereby regulating blood pressure, and its effective active ingredients can also regulate blood sugar.

The invention adopts diploid and tetraploid Gynostemma pentaphyllum to be compatible with traditional health-care traditional Chinese medicines such as frost mulberry leaves, Eucommia ulmoides leaves and Radix Puerariae, and can effectively promote the self-regulating function of human health, thereby achieving dredge blood circulation, vomiting new, strong viscera and reducing " Three high." The formula is all made up of plants with health benefits. Compared with western medicine, it is not only low cost, no side effects, but also provides many healthy saponins, polyphenols, flavonoids, polysaccharides and minerals. Nutrients such as elements make the human body healthier.

Compared with conventional drugs, the invention is unique in that it starts from the source of “three highs” and promotes the metabolism and self-regulation of human cells through various reasonable ratios of various health medicines, lowering blood fat and blood circulation. Strong five internal organs, promote balance, improve the biological activity of the vascular system, soften blood vessels, eliminate hidden dangers, increase permeability, and inhibit "three highs". Fundamentally solve the "three highs" problem, and finally achieve the purpose of rehabilitation and health.

detailed description

The invention is further illustrated by the following examples in which the percentages are by weight, but the invention is not limited thereto.

Example 1

Diploid Gynostemma 30%, Tetraploid Gynostemma 30%, Eucommia Leaf 15%, Frost Mulberry Leaf 15%, Pueraria Root Powder 10%

Example 2

Diploid Gynostemma 20%, Tetraploid Gynostemma 30%, Eucommia ulmoides 20%, Frost Mulberry Leaves 20%, Pueraria Root Powder 10%

Example 3

Diploid Gynostemma 30%, Tetraploid Gynostemma 20%, Eucommia Leaves 20%, Frost Mulberry Leaves 15%, Pueraria Root Powder 15%

Example 4

Diploid Gynostemma 25%, Tetraploid Gynostemma 25%, Eucommia ulmoides 20%, Frost Mulberry Leaves 20%, Pueraria Root Powder 10%

Example 5

Diploid Gynostemma 20%, Tetraploid Gynostemma 18%, Eucommia Leaf 30%, Frost Mulberry Leaves 20%, Pueraria Root Powder 12%

Example 6

Diploid Gynostemma 15%, Tetraploid Gynostemma 15%, Eucommia Leaf 35%, Frost Mulberry Leaf 30%, Pueraria Root Powder 5%

Example 7

Diploid Gynostemma 28%, Tetraploid Gynostemma 30%, Eucommia Leaf 15%, Frost Mulberry Leaf 17%, Pueraria Root Powder 10%

Example 8

Diploid Gynostemma 20%, Tetraploid Gynostemma 20%, Eucommia Leaf 25%, Frost Mulberry Leaves 25%, Pueraria Root Powder 10%

Example 9

The products in the embodiments 1-8 of the present invention were tested according to the national selenium-enriched food standard GB28050-2011, and the test results showed that the selenium content of the invention was 0.20-5.00 mg/kg, which met the selenium-enriched food product standard. High-performance liquid chromatography (HPLC)-based improved new technology to detect products containing: saponin 108.4 ~ 188.2mg / g; polyphenols 23.5 ~ 37.5mg / g; total flavonoids 22.5 ~ 36.5mg / g.

The invention has the effects of preventing and treating hyperlipemia, hypertension and hyperglycemia.

While the invention has been described with respect to the specific embodiments of the embodiments of the present invention, it is to be understood by those skilled in the art Variations and modifications of the above-described embodiments are intended to fall within the scope of the claims as claimed.

Claims

A compound Chinese medicine composition containing Gynostemma pentaphyllum, characterized in that the compound Chinese medicine composition containing Gynostemma pentaphyllum is prepared by mixing Gynostemma pentaphyllum, Eucommia ulmoides leaves, Frost mulberry leaves and Pueraria lobata powder as raw materials, in parts by mass: Gynostemma 30 ~60%, eucommia leaves 15 to 35%, frost mulberry leaves 15 to 35%, and Pueraria lobata powder 5 to 15%.
The compound Chinese herbal medicine composition containing Gynostemma pentaphyllum according to claim 1, wherein the compound Chinese medicine composition containing Gynostemma pentaphyllum is prepared by mixing the following raw materials in parts by mass: 50 to 60% of Gynostemma pentaphyllum, and 15 to 25 of Eucommia ulmoides leaves. %, frost mulberry leaves 15 to 25%, and Pueraria lobata powder 8 to 12%.
The compound Chinese herbal composition containing Gynostemma pentaphyllum according to claim 2, wherein each raw material of the compound Chinese herbal medicine composition containing Gynostemma pentaphyllum is in parts by mass: 60% of Gynostemma pentaphyllum, 15% of Eucommia ulmoides leaves, and mulberry leaves 15%, Pueraria lobata powder 10%.
The compound Chinese herbal composition containing Gynostemma pentaphyllum according to any one of claims 1 to 3, wherein the Gynostemma pentaphyllum is a mixture of diploid Gynostemma pentaphyllum leaves and tetraploid Gynostemma pentaphyllum leaves.
The compound Chinese herbal composition containing Gynostemma pentaphyllum according to claim 4, wherein the diploid Gynostemma pentaphyllum leaves are in parts by mass: tetraploid Gynostemma pentaphyllum leaves = 2:3 to 3:2.
The compound Chinese herbal composition containing Gynostemma pentaphyllum according to claim 5, wherein the diploid Gynostemma pentaphyllum leaves are in parts by mass: tetraploid Gynostemma pentaphyllum leaves = 1:1.
The compound Chinese herbal medicine composition containing Gynostemma pentaphyllum according to any one of claims 1 to 3, wherein the compound Chinese herbal medicine composition containing Gynostemma pentaphyllum is prepared into tablets, pills, granules, and granules.
A method for preparing a compound Chinese herbal medicine composition containing Gynostemma pentaphyllum according to claim 1, comprising the steps of:

1) The Gynostemma pentaphyllum leaves and Eucommia ulmoides leaves and frost mulberry leaves are washed and dried at 60-80 ° C. The moisture content of the raw materials after drying is controlled within 7%.

2) The dried raw materials are pulverized, proportioned, mixed, and granulated according to the formulation.

3) Placed in a dry heat sterilization cabinet for sterilization and drying, and the water content is controlled within 4%.

4) Store in a small, dry package according to the dosage, and store in a cool dry place.
The use of the compound Chinese herbal medicine composition containing Gynostemma pentaphyllum according to claim 1, wherein the compound Chinese herbal composition containing Gynostemma pentaphyllum is used for preventing hyperlipemia, hypertension, hyperglycemia, anti-aging, and improving human immunity. the use of.