WO2017143461A1 - Dispositif d'injection permettant le dosage et la distribution d'une dose définie d'un produit fluide - Google Patents

Dispositif d'injection permettant le dosage et la distribution d'une dose définie d'un produit fluide Download PDF

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Publication number
WO2017143461A1
WO2017143461A1 PCT/CH2017/000009 CH2017000009W WO2017143461A1 WO 2017143461 A1 WO2017143461 A1 WO 2017143461A1 CH 2017000009 W CH2017000009 W CH 2017000009W WO 2017143461 A1 WO2017143461 A1 WO 2017143461A1
Authority
WO
WIPO (PCT)
Prior art keywords
housing
sleeve
injection device
click
stop
Prior art date
Application number
PCT/CH2017/000009
Other languages
German (de)
English (en)
Inventor
Christian Schrul
Jürg HIRSCHEL
Original Assignee
Tecpharma Licensing Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tecpharma Licensing Ag filed Critical Tecpharma Licensing Ag
Publication of WO2017143461A1 publication Critical patent/WO2017143461A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31553—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe without axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2448—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3125—Details specific display means, e.g. to indicate dose setting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/581—Means for facilitating use, e.g. by people with impaired vision by audible feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/582—Means for facilitating use, e.g. by people with impaired vision by tactile feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/583—Means for facilitating use, e.g. by people with impaired vision by visual feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3156—Mechanically operated dose setting member using volume steps only adjustable in discrete intervals, i.e. individually distinct intervals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566—Means improving security or handling thereof
    • A61M5/3157—Means providing feedback signals when administration is completed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod

Definitions

  • Injection device for metering and dispensing a dose of a fluid product
  • the invention relates to an injection device for the metering and distribution of a dose of a fluid product, in particular a medicament.
  • the injection device comprises a multi-part piston rod with a Kllck sleeve and an ejection element.
  • the term "medicament” includes any fluid medical formulation suitable for controlled administration by an agent, such as an agent.
  • a cannula or a hollow needle for example comprising a liquid, a solution, a gel or a fine suspension, softis) containing one or more medicinal agents, medicament may comprise a single-agent composition or a premixed or co-formulated composition multiple agents from a single container.
  • Drug includes drugs such as peptides (eg, insulins, insulin-containing drugs, GLP-1 containing as well as derived or analogous preparations), proteins and hormones, biologically derived or active agents, hormone or gene based drugs, nutritional formulas, enzymes, and other substances both in the art solid (suspended) or liquid form but also polysaccharides, vaccines, DNA or RNA or OligonuMeotide, antibodies or parts of antibodies and suitable base, excipients and carriers.
  • drugs such as peptides (eg, insulins, insulin-containing drugs, GLP-1 containing as well as derived or analogous preparations), proteins and hormones, biologically derived or active agents, hormone or gene based drugs, nutritional formulas, enzymes, and other substances both in the art solid (suspended) or liquid form but also polysaccharides, vaccines, DNA or RNA or OligonuMeotide, antibodies or parts of antibodies and suitable base, excipients and carriers.
  • drugs such as peptides (
  • injection devices are known from the prior art. Injection devices are known from WO2013 / 178512 A1 and US Pat. No. 8,821,451 B2, wherein in each of these injection devices the distribution of the dose is indicated.
  • the proximal direction means the direction toward the case-side end and the distal direction in an injection device means the direction toward the needle-side end.
  • the invention relates to an injection device for metering and for delivering a dose of a fluid product.
  • the injection device comprises a housing having a plurality of stops or a metering stop fixedly connected to the housing and having a plurality of stops, in particular a plurality of stops
  • the injection device has a detachable from the housing or one of the fixedly connected to the housing Dosierstopp multi-part piston rod, wherein the multipart
  • Piston rod comprises a click sleeve and an ejection element. Furthermore, a spring mounted in the housing or in the housing firmly connected to the metering stop is provided, which acts on at least a part of the piston rod with a force.
  • the ejection element may be rotatable relative to the housing or to the metering stop integral with the housing for adjusting a dose to be administered.
  • the ejection element may have a Ausstosselementanschlag, which in a second state of Injection device in which the multi-part piston rod is detached from the housing or from the metering stop fixedly connected to the housing, is or is in contact with one of the plurality of stops of the housing or metering stop, in particular with one of the plurality of metering stop stops.
  • the injection device may preferably be designed such that in a first state of the injection device, in which the multi-part piston rod with the housing or with the housing firmly connected Dosierstopp is releasably connected, the click sleeve rotatably and / or axially fixed relative to the ejection element is arranged, and that in the second state of the injection device, the click sleeve is detachable from the ejection element and is axially movable relative to the ejection element, such that the click sleeve is in stop contact with the ejection element can be achieved.
  • the click sleeve in the second state of the injection device relative to the
  • Ejection element be axially movable until the click sleeve is in abutting contact with the ejection element and generates an audible signal to indicate that the distribution of the dose is completed. This may serve to ensure that the user does not pull the hypodermic needle of the injection device out of the skin prior to the completion of the injection and thus completely administer the adjusted dose to be administered.
  • the metering stop is axially fixed and rotatably connected to the housing.
  • the Dosierstopp and the housing may be formed in two parts. Alternatively, the metering stop and the housing may be integrally formed.
  • the housing or the metering stop fixed to the housing may surround the click sleeve.
  • the click sleeve can be mounted axially movable on the ejection element.
  • the click sleeve may comprise a click sleeve holding member which in the first state of the injection device is engaged with a click sleeve holding counter element disposed on the ejection element and the click sleeve holding member is disengaged in the second state of the injection device the click sleeve holding counter element is engageable.
  • the click sleeve holding member may be formed as a click sleeve holding arm.
  • the click sleeve retaining counter element may be formed as Ausstosselementaussparung.
  • the housing or the dosing stop fixedly connected to the housing may be designed in such a way that in the first state of the injection device the click sleeve holding element can be held in engagement with the click sleeve holding counter element.
  • the housing or the dosing stop fixedly connected to the housing can also be designed such that in the second state of the injection device the click sleeve holding element can be brought out of engagement with the click sleeve holding counter element.
  • the housing or the dosing stop firmly connected to the housing can have a recess, wherein the click sleeve holding element can be brought into the recess.
  • Dosierstopps may be associated with a corresponding recess.
  • the click sleeve and the ejection element can form a cooperating guide link, in particular in each case a cooperating
  • the guide slot in particular the two screw portion-shaped guide surfaces may be formed such that a relative rotation and / or a relative axial movement between the click sleeve and the ejection element is executable.
  • the injection device may further comprise a holding sleeve, which is designed such that in the first state of the injection device relative rotation between the click sleeve and the ejection element can be prevented.
  • the retaining sleeve may have a rib.
  • the rib of the retaining sleeve can be designed such that the rib of the retaining sleeve can interact with the ejection element stop of the ejection element, in particular with a notch of the ejection element stop and with a groove arranged on the proximal end of the click sleeve.
  • a relative rotational movement between the click element and the ejection element can be prevented by the engagement between the rib of the retaining sleeve and the notch of the Ausstosselementanschlags and by the engagement between the rib of the retaining sleeve and the groove of the click sleeve.
  • the retaining sleeve can be movable relative to the click sleeve in the axial direction, in particular in the proximal direction.
  • the holding sleeve can be brought into abutment contact with the set stop of the housing or the dosing stop firmly connected to the housing. Due to the axial relative movement of the ejection element to the housing or to the housing firmly connected Dosierstopp can due to the stop contact between the rib of the retaining sleeve and a set dose corresponding stop of the housing or fixed to the housing Dosierstopp the retaining sleeve axially relative to move the ejection element in the proximal direction. The rib of the retaining sleeve can get out of engagement with the groove of the click sleeve. Due to the force of the spring acting on the click sleeve and the cooperating guide slot between the click sleeve and the ejection element, the click sleeve may rotate relative to the ejection element,
  • the plurality of stops provided on the housing or on the metering stop fixedly connected to the housing can be designed in a staircase shape.
  • a step can be set as a stop to set the appropriate dose to be administered.
  • the attacks can be designed as a stair member.
  • the stops can be provided on the metering stop and be designed as Dosierstoppanoeuvre.
  • guide ribs may be provided on the housing or on the dosing stop fixedly connected to the housing, the different lengths of the guide ribs corresponding to a dose to be administered can. The Ausstosselementanschlag can be performed along a set guide rib of the housing or firmly connected to the housing Dosierstopp.
  • the multi-part piston rod can be releasably connected to the housing or to the housing permanently connected metering stop.
  • the ejection element stop provided on the ejection element can be in abutting contact with a stop surface arranged on the housing or with a stop surface arranged on the metering stop fixedly connected to the housing.
  • the multi-part piston rod can be detached from the housing or from the dosing stop firmly connected to the housing.
  • the ejection element provided on the ejection element
  • Ausstosselementanschlag be out of abutting contact with a arranged on the housing stop surface or with a arranged on the fixedly connected to the housing Dosierstopp stop surface.
  • the expelling member may be rotated relative to the housing or to the metering stop integral with the housing to adjust a dose to be administered.
  • the injection device may further preferably comprise a holding needle, wherein the holding needle may be received by the ejection element, and the holding needle may be acted upon by a force of the spring.
  • the holding needle may be axially movable with the force of the spring relative to the cartridge sleeve until the holding needle is in abutting contact with the click sleeve and produces an audible signal to indicate that the dose is being delivered to indicate to the user that the administration of the fluid product begins.
  • the injection device may further comprise an adjusting sleeve.
  • the adjustment sleeve may be axially fixedly connected to the housing or metering stop integral with the housing and rotatably mounted relative to the housing or to the metering stop integral with the housing to adjust a dose to be administered.
  • the adjustment knob may include a dose indicator, particularly in the form of numerals, letters or characters, to indicate to the user the adjusted dose to be administered by a window provided on the housing or by a metering stop fixedly attached to the housing.
  • the injection device may further comprise a sliding sleeve.
  • a sliding sleeve In one embodiment of the
  • the sliding sleeve is arranged axially displaceable in the proximal direction relative to the housing or relative to the metering stop fixedly connected to the housing.
  • a sliding sleeve edge of the sliding sleeve can be detachably supported in the distal direction on the housing or on the metering stop firmly connected to the housing, and on the other hand a Schiebehülsenschnapparm the sliding sleeve in the proximal direction to the housing or on the fixedly connected to the housing Dosierstopp be releasably supported.
  • the Schiebehülsenschnapparm the sliding sleeve and provided on the housing Gesimouseausnehtnung or provided on the fixedly connected to the housing Dosierstopp Dosierstoppaus simplifiedung can be designed such that the Schiebehülsenschnapparm can engage in the Dosierstoppaus aloneung.
  • the sliding sleeve snap arm may be provided in the housing provided on the housing
  • the sliding sleeve can furthermore comprise a sliding sleeve lever, which can have a sliding sleeve cam, wherein a sliding sleeve locking wing can be arranged in each case on both sides of the sliding sleeve cam.
  • the sliding sleeve lever can be designed to be elastic in the radial direction, in particular to be elastically tensionable, such that the sliding sleeve cam of the sliding sleeve lever is arranged over an adjusting sleeve groove arranged longitudinally on the jacket inner surface of the adjusting sleeve and over an adjusting sleeve rib arranged longitudinally on the jacket inner surface of the adjusting sleeve, in particular over several Adjusting sleeve grooves of the adjusting sleeve and can slide along several Einstelihülsenrippen the adjusting sleeve along.
  • the housing or the dosing stop firmly connected to the housing may have a support surface and an opening, wherein the support surface may be arranged distally of the opening.
  • Sliding sleeve locking wing of the sliding sleeve can rest on the support surface such that a radial deflection of the sliding sleeve cam of the sliding sleeve lever can be prevented.
  • a relative rotation between the adjusting and the housing or firmly connected to the housing Dosierstopp can be prevented.
  • the sliding sleeve locking wings of the sliding sleeve can protrude into the opening of the housing or of the metering stop firmly connected to the housing in such a way that a radial deflection of the sliding sleeve cam of the sliding sleeve lever can be permitted.
  • a relative rotation between the adjusting sleeve and the housing or the metering stop firmly connected to the housing can be permitted, wherein a dose to be administered can be set.
  • the sliding sleeve locking wings lie on the bearing surface of the housing or the dosing stop firmly connected to the housing.
  • the sliding sleeve locking wings lie in the opening of the housing or the dosing stop firmly connected to the housing.
  • Injection device is vented, performed and / or an axial clearance between the Mehrkam merkarpule, especially the 2-chamber carpule and a Karpuienhalter or between the Karpulenhalier and the housing is reduced or even eliminated.
  • the recorded with the 2-chamber carpule carpal holder can be inserted into the interior of the housing.
  • the carpal holder can over a
  • Threaded connection are screwed into the housing. After mixing, the carpule holder can be further guided or screwed into the housing, so that the sliding sleeve can be moved in the proximal direction.
  • the mixing indicator of the carpule holder can be seen by a provided on the housing housing window, which may be visible to the user, in which position the injection device is.
  • the housing may have a housing opening, in particular a plurality of housing openings, in which one or more provided on the Karpuienhalter Karpulenhalterrastarme can engage to a remindschiebe- or
  • the sliding sleeve can be in a proximal position, the sliding sleeve being axially fixed relative to the housing or to the dosing stop fixedly connected to the housing.
  • the injection device can be a holding element for holding and / or fixing and / or positioning a Carpule, in particular a one-chamber carpule include.
  • a carpule may be held free of play on or in a carpule holder.
  • the carpule may comprise in a chamber a fluid product to be administered.
  • the carpule can be held in the carpal holder on the distal side in axial stop contact and on the proximal side by means of the holding element. In this way, manufacturing and assembly tolerances can be compensated.
  • the holding element may preferably be formed elastically deformable.
  • the retaining element may have a ring element.
  • the ring element may be sleeve-shaped.
  • the ring element may further preferably be cylindrical.
  • a first and a second spring seat may be provided on the ring member.
  • the ring member may comprise a plurality of brackets and a plurality of connecting webs, wherein the first spring seat may be connected via the plurality of brackets and the plurality of connecting webs with the second spring seat.
  • the brackets extend in the circumferential direction, wherein they can be formed curved against distal or against proximal.
  • the first spring seat may be connected via a first connecting web to a first bracket, wherein the first bracket may be connected via a second connecting web to a second bracket and the second bracket via a second connecting web to the second spring seat.
  • the first and second brackets can form elastic bending arms.
  • the first and the second bracket can thus via the connecting webs in protrude axially from the first and the second spring seat, Alternatively, a different number of brackets, connecting webs and spring seats may be provided on the holding element.
  • the ring element can also have a different configuration, provided that the ring element along the axial axis can be claimed for pressure.
  • the Haiteelement may have a projection, a clamping element and a spring element.
  • the projection and the clamping element can be connected via the spring element with the holding element.
  • the projection may protrude radially outwards from the spring element, and the clamping element may project radially inwards from the spring element.
  • the spring element can be arranged on the first spring seat.
  • the holding element may comprise a cam, wherein the cam may be arranged on the second spring seat and may protrude radially outward.
  • the carpule holder may further, in a first position, in which the carpule is movably received in the carpule holder, and in a second position, wherein the carpule is received and fixed in the carpule holder, at least partially hold the holding element in an annular gap between the carpule holder and the carpule ,
  • the holding element may be designed such that the holding element in the second position of the carpule holder can hold the carpule axially free of play relative to the carpule holder. In this case, the carpule in the distal direction on or in the
  • the projection of the holding element can be latched into a recess of the carpule holder.
  • the connection between the projection of the holding element and the recess of the carpule holder may be detachable.
  • the projection of the holding element In the second position of the carpule holder, the projection of the holding element can be pressed out of the recess of the carpule holder, wherein the arranged on the second spring seat cam of the holding element can pass into the recess of the carpule holder to elastically bias the holding member.
  • the connection between the cam of the retaining element and the recess of the carpule holder may be formed insoluble.
  • the clamping element of the holding element can hold or embrace a proximal carpule edge of the carpule in the second position of the carpule holder.
  • the carpule can be kept free of play between the carpule holder and the holding element in the carpule holder.
  • a tool for example a pushing or pushing device, can act on the second spring seat of the half element in such a way that the hair element is moved axially in the distal direction relative to the carpule holder.
  • the carpule holder can be glued or welded to the housing of the injection device. Alternatively, other fastening means between the carpule holder and the housing may be provided.
  • the injection device may further comprise a trigger sleeve.
  • the release sleeve can be axially fixed and rotatably connected to the adjusting sleeve.
  • the release sleeve and the adjusting sleeve may alternatively be formed in one piece.
  • the injection device may comprise a trigger button.
  • the trigger button may be arranged to be axially movable in the distal direction relative to the housing or to the dosing stop firmly connected to the housing.
  • the release button and the release sleeve may be configured such that the release button is axially movable relative to the release sleeve in the distal direction and is axially lockable in the proximal direction.
  • a corresponding ratchet connection in the form of one or more recesses and one or more snap arms may be provided on the release button and on the release sleeve.
  • Ratchet connection between the trigger button and the trigger sleeve may serve to allow the user to move the trigger button only once in the distal direction, or the user may administer a set dose only once.
  • an initial position in which the Injetechnischsvorrichtu ng is delivered, it can be provided that an axial movement of the Abd Wegknopf can be prevented in the distal direction relative to the housing or to the fixedly connected to the housing Dosierstopp.
  • a position with set dose of the injection device it can be provided that an axial movement in the distal direction relative to the housing or to the fixedly connected to the housing Dosierstopp is possible.
  • the release button may have a tab which is supported on a rib of the housing or on a rib of the metering stop fixedly connected to the housing, in particular supported on a wide rib of the housing or on a wide rib of the metering stop firmly connected to the housing, wherein the support is releasable by a relative rotation between the release button and the housing or the metering stop fixedly connected to the housing.
  • the housing or the dosing knob fixedly connected to the housing can have further ribs, in particular narrow ribs, wherein the tab of the trigger button can slide along a narrow rib of the housing or a narrow rib of the dosing stop firmly connected to the housing.
  • a groove may be provided which may be in engagement with a retaining arm of the trigger sleeve to hold the retaining needle in a proximal position. Further, a recess may be provided on the release button to receive the support arm, so that the support arm of the release sleeve is disengaged from the holding needle can be brought.
  • Figure 1 is an exploded view of a first embodiment of an inventive
  • Figure 2a is a longitudinal sectional view of the injection device of Figure 1 in a first state in which the multi-part piston rod (8, 9) with the Dosierstopp (2) is detachably connected, and in an initial position in which the injection device is delivered, wherein the longitudinal sectional view of in the figure 2d drawn section line AA corresponds.
  • Figure 2b is a longitudinal sectional view of the injection device according to Figure 2a, wherein the
  • FIG. 2c shows a cross-sectional view of the injection device from FIG. 1 in the first state, in FIG
  • FIG. 3 shows a longitudinal sectional view of the injection device from FIG. 1 in the first state
  • Figure 4a is a longitudinal sectional view of the injection device of Figure 1 in the first state in which the multi-part piston rod (8, 9) with the Dosierstopp (2) is releasably connected, in a primed position in which the injection device is vented, said
  • Figure 4b is a longitudinal sectional view of the injection device according to Figure 4a, wherein the
  • FIG. 4c shows a cross-sectional view of the injection device from FIG. 1 in the first state, in FIG
  • FIG. 4d shows a perspective view of a distal part of the metering stop (2) and of a proximal part of the sliding sleeve (3) of the injection device from FIG. 1 in the first state, in which the multipart piston rod (8, 9) is detachably connected to the metering stop (2) , in the primed position, in which the injection device is vented, wherein the Einsteilhülse (4) is recessed,
  • Figure 5a is a longitudinal sectional view of the injection device of Figure 1 in the first state in which the multi-part piston rod (8, 9) with the dosing stop (2) is detachably connected, and set in a dose position, wherein the longitudinal sectional view of the drawn in Figure 2d Section line AA corresponds,
  • Figure 5b is a perspective view of Dosierstopps (2), the proximal part of the sliding sleeve (3) and a distal part of the trigger button (6) of the injection device of Figure 1 in the first state in which the multi-part piston rod (8, 9) with the Dosierstopp (2) is detachably connected, and in the dose adjusted position, the Einstelihülse (4) is recessed,
  • FIG. 6 a shows a longitudinal sectional view of a proximal part of the injection device from FIG. 1 in the first state in which the multi-part piston rod (8, 9) can be released with the metering stop (2) is connected, and triggered in a dose position, wherein the longitudinal sectional view of the drawn in Figure 2e section line BB corresponds.
  • FIG. 10a a longitudinal sectional view of the injection device of Figure 9 in a first state in which the multi-part piston rod (8, 9) with the Dosierstopp (2) is detachably connected, and in an initial position in which the injection device is delivered, wherein the longitudinal sectional view corresponding to the in 2d shows a sectional view AA, a longitudinal sectional view of the injection device according to FIG. 10a, wherein the
  • FIG. 11 b is a longitudinal sectional view of the injection device according to Figure 11a, with only the multipart
  • Piston rod (8 1 , 9 '), the retaining needle (7'), the spring (12) and the retaining sleeve (14) are shown.
  • FIG. 12 is a longitudinal sectional view of the injection device of the third embodiment of FIG.
  • Figure 13a is a perspective view of the third embodiment of an inventive
  • FIG. 13b shows a longitudinal sectional view of the injection device according to FIG. 13a, wherein only the multipart
  • Piston rod (8 ', 9'), the retaining needle (7 '), the spring (12 1 ) and the retaining sleeve (14) are shown.
  • FIG 1 is an exploded view of a first Ausunjngsform the inventive
  • the injection device comprises a housing (1) and with the housing (1) axially fixed and rotationally fixed Dosierstopp (2).
  • a metering stop cam (2a) provided on the metering stop (2) is engaged in a housing recess (1a) provided on the housing (1).
  • a metering stop edge (2b) provided on the metering stop (2) is in abutting contact with a proximal housing stop (2b, 1b) provided on the housing.
  • a Dosierstopprippe (2c), in particular two Dosierstopprippen (2c) are provided on the Dosierstopp (2c) which notch in a provided on a shell inner surfaces housings (not visible) of the housing (1), in particular in two provided on a sheath inner surface housing notches (not shown) protrude,
  • the injection device further comprises a sliding sleeve (3).
  • the sliding sleeve (3) is non-rotatably connected to the housing (1),
  • a sliding sleeve rib (3a) provided on the sliding sleeve (3) projects into a housing groove provided on the shell inner surface (FIGS. 2a, 1g).
  • the sliding sleeve (3) is arranged axially displaceable in the proximal direction relative to the housing (1) and the metering stop (2).
  • a sliding sleeve edge (3b) of the sliding sleeve (3) can be released on the one hand axially in the distal direction on a distal housing stop (FIG. 2b; 1c) of the housing (1)
  • a sliding sleeve snap arm (3c) of the sliding sleeve (3) can be detachably supported axially in the proximal direction on a metering stop catch (2e) of the metering stop (2).
  • the Schiebehülsenschnapparm (3c) of the sliding sleeve (3) and one on the Dosierstopp (2) provided
  • Dosierstoppaus simplifiedung (2i) may be formed such that the Schiebehülsenschnapparm (3c) can engage in the Dosierstoppaus biologyung (2i).
  • the injection device further comprises an adjusting sleeve (4).
  • the adjusting sleeve (4) is axially fixed to the Dosierstopp (2) and the housing (1).
  • the adjusting sleeve (4) has an adjusting sleeve projection (2a, 4a), which is in abutting contact with a dosing stop ring groove (2d) provided on the dosing stop (2). Further, on the adjusting knob (4) a
  • Adjusting sleeve ring edge (4b) is provided which in abutting contact with a on the housing (1) mounted housing edge (1d).
  • the adjustment sleeve (4) is rotatably mounted relative to the housing (1) and the metering stop (2) to adjust a dose to be administered.
  • the adjustment knob (4) can be a
  • Dose indicator (not shown), in particular in the form of numbers, letters or characters.
  • the dose indicator (not shown) of the adjustment knob (4) may be visible through a housing dose window (1i) provided on the housing (1), which may be visible to the user as to which dose to dose.
  • the sliding sleeve (3) has a
  • Sliding sleeve lever (3d) which comprises a sliding sleeve cam (3d '), wherein a sliding sleeve locking wing (3d ") is arranged on both sides of the sliding sleeve cam (3d').
  • the sliding sleeve lever (3d) is elastic in the radial direction, in particular elastically tensionable , such that the
  • the metering stop (2) comprises a metering stop bearing surface (2o) and a metering stop opening (2p), wherein the metering stop bearing surface (2o) is arranged distally to the metering stop opening (2p).
  • the sliding sleeve locking wings (3d ") of the sliding sleeve (3) can rest on the metering stop bearing surface (2o) such that radial deflection of the sliding sleeve cam (3d ') of the sliding sleeve lever (3d) can be prevented.
  • relative rotation between the adjusting sleeve (3) can be prevented.
  • the housing (1) and the dosing stop (2) can be prevented
  • the release sleeve (5) comprises a release sleeve rib (5c), in particular two release sleeve ribs (5c), which is in engagement with a Auslöcherhülsenverfit Anlagensnut (not visible) attached to a shell inner surface of the Einsteühülse (4).
  • the injection device further comprises a trigger button (6).
  • the trigger button ⁇ 6 ⁇ is non-rotatably connected to the adjusting sleeve (4), For this purpose, on the release button (6) attached Auslettesknopfnppe (6a) in engagement with a provided on a shell inside the trigger sleeve (5) Ausletteshülsennut (not shown).
  • the trigger button (6) is arranged to be movable axially relative to the housing (1) and the dosing stop (2) in the distal direction.
  • Trigger sleeve (5) mounted Ausletteshülsenschnapparm (5d) can be supported axially in the distal direction on an edge of the trigger button rib (6a).
  • the trigger button (6) further comprises a distal
  • a trigger button edge (6e) of a trigger button guide tab (6d) of the trigger button (6) may be supported on a dosing stop edge (2f) of a wide dosing stop ratchet (2g ') of the dosing stop (2), the support being supported by relative rotation between the trigger button (6). and the dosing stop (2) is releasable.
  • the trigger button (6) further includes a trigger button contact tab groove (6e) disposed on a shell inner surface of the trigger button guide tab (6d) of the trigger button (6).
  • Trigger button guide tab groove (6e) of the trigger button (6) is adapted to slide along a narrow dosing stop rib (2g ") provided on the dosing stop (2)
  • the dosing stop (2) comprises a plurality of narrow dosing stop ribs (2g").
  • the trigger button guide tab (6d) can be axially guided between the two trigger sleeve ribs (5c) of the trigger sleeve (5)
  • Injection device further comprises a holding needle (7) and a spring (12), the spring (12) is biased at the distal end to a on the holding! (7) provided retaining needle stop (7a) and at the proximal end to a on the release sleeve (5) mounted Ausletteshülsenabstütz Structure ( Figure 2a, 5e) supported.
  • the retaining needle (7) furthermore comprises a retaining needle groove (7b), in particular two retaining needle grooves (7b).
  • Triggering sleeve (5) further comprises a Ausiuitehülsenhalteann (Figure 2b, 5g), in particular two
  • Triggering sleeve holding arms (Figure 2b, 5g), which are designed such that they can engage in the retaining needle groove (7b), in particular in the two retaining needle grooves (7b) to hold the retaining needle (7) relative to the housing (1) can.
  • a release button recess (6f) is provided on the release button (6), in particular two release button recesses (6f) which can receive the release sleeve retaining arm (2b, 5g), in particular the two release sleeve retaining arms (2b, 5g) such that the release sleeve retaining arm (FIG. 2b, 5g), in particular the two Ausrierehülsenhaltearme (Figure 2b, 5g) out of engagement with the
  • Retaining needle groove (7b), in particular the two retaining needle grooves (7b) of the retaining needle (7) get.
  • Injection device further comprises a multi-part piston rod (8, 9).
  • the multi-part piston rod (8, 9) comprises an ejection element (8), the ejection element (8) is arranged relative to the housing (1) and the Dosierstopp (2) axially movable in the distal direction.
  • a multi-part piston rod (8, 9) comprises an ejection element (8), the ejection element (8) is arranged relative to the housing (1) and the Dosierstopp (2) axially movable in the distal direction.
  • Ejection stopper (8a) provided with a Ausstosselementanschlagkerbe (8b).
  • a metering stop guide rib (FIGS. 8a, 2j ', 2j ", 2j"') provided on the metering stop (2) can be located in the
  • the dosing stop (2) has a plurality of dosing stopper tubes (8a, 2j ', 2j ", 2j"'), wherein a length of the dosing stop guide rib (8a, 2j ', 2j ", 2j"') corresponds to an adjustable dose,
  • Ejection element stop (8a) can be brought into abutment contact with a dosing stop step element (FIG. 8a 2k) provided on the inside of the dosing stop (2), in particular with a dosing stop stop corresponding to the selected dose (FIG. 8a, 21 ', 21 ", 21"') be.
  • the Dosierstopptpenpenglied ( Figure 8a, 2k) has various Dosierstoppanoeuvre ( Figure 8a, 21, 21 ", 21"), wherein by a
  • Stair step is set as a stop to set the dose to be administered.
  • the various Dosierstoppanoeuvre ( Figure 8a, 2 ⁇ ', 21 ", 2 ⁇ "), for example, with a small, medium or large dose correspond.
  • the Ausstosseiement (8) further comprises a Ausstosselementschulfer (8c).
  • the ejection element shoulder (8c) is supported axially in the proximal direction on a first dosing stop shoulder (FIG. 2b, 2m ') provided on the inner surface of the dosing stop.
  • the Ausstosseiement (7) is rotatably connected to the trigger sleeve (5).
  • the Ausstosseiement (8) has a rib (not shown), in particular two Ausstosselementrippen (not shown), which are in engagement with a provided on the release sleeve (5) Ausl Harborhülsennut (5f).
  • the multi-part piston rod (8, 9) further comprises a Kick sleeve (9).
  • the click sleeve (9) is mounted on the ejection sleeve (8) axially movable in the distal direction.
  • a click sleeve holding element (9a) for example in the form of a click sleeve holding arm (9a) is provided on the click sleeve (9) which engages with a click sleeve counter element (8d) provided on the ejection element (8) in the form of a Ausstosselementaussparung (8d),
  • the click sleeve holding member (9a), in particular the click sleeve holding arm (9a) is elastic, in particular elastically tensioned.
  • the click sleeve holding member (9a) may further be engageable with a metering stop recess (2n) provided on the shell inner surface of the metering stop (2), the click sleeve holding member (9a) of the click sleeve (9) being disengaged from the click sleeve (8d) of the ejection element can be brought.
  • a plurality of Dosierstoppaussparept (2n) are provided, which correspond to a set dose.
  • the click sleeve (9) further comprises a click sleeve shoulder (9e), the click sleeve shoulder (9e) is axially in the proximal direction to one of the
  • the click sleeve (9) is non-rotatably connected to the ejection element (8), for this purpose the click sleeve (9) has a short sleeve anti-rotation locking surface (9b).
  • the click sleeve (9) has at its distal end a click sleeve inner surface ( Figure 2a; 9c) and a click sleeve outer surface (9d).
  • the retaining needle stop (7a) of the retaining needle (7) may be in contact with the collar surface ( Figure 2a; 9c) of the click sleeve, with an acoustic noise, in particular an audible or tactile audible noise, indicating that the injection process has begun
  • the click-sleeve outer surface (9d) of the click Sleeve (9) can come into abutting contact with an ejection element inner surface (8f) provided on the ejection element (8), wherein an acoustically or tactually perceptible noise, in particular an acoustic noise, which indicates that the injection process has ended, can arise.
  • the injection device further comprises a carpule holder (10), in which a carpule (10) is received.
  • the carpule (11) is designed as a 2-chamber carpule (11), which a first chamber ( Figure 2a, 11 a), which is bounded by a first plug ( Figure 2a, 11 b), and a second chamber (FIG 2a, 11c) bounded by the first plug ( Figures 2a, 11b) and a second plug ( Figures 2a, 11d).
  • the carpule holder (10) comprises a cartridge holder external thread (10a) which is engaged in a housing internal thread (le) provided on the housing (1).
  • a bypass (FIGS. 2b, 11e) is provided in the circumference of the wall of the 2-chamber carpule (11), through which solvent from the second chamber (FIG.
  • the blending indicator (10b) of the carpule holder (10) may be visible through a housing window (1f) provided on the housing (1), which may be visible to the user in which position the injection device is.
  • the housing (1) can have a housing opening (1 h), in particular a plurality of housing openings (1 h) into which one or more carpule-holder latching arms (10c) provided on the carpule holder (10) can engage in order to form a push-back or reverse-rotation safety device safe administration of the fluid product can be ensured.
  • a needle connection element (10d) which is provided for the releasable attachment of an injection needle (not shown).
  • a carpule holder edge (10e) is provided at the proximal end of the carpule holder (10).
  • Injection device may further comprise a closure cap (not shown), which may be connectable via a detachable connection with the carpule holder (10),
  • FIG. 2 a is a longitudinal sectional view of the injection device from FIG. 1 in a first state in which the multi-part piston rod (8, 9) is detachably connected to the dosing stop (2) and in an initial position in which the injection device is delivered, shown, wherein the
  • FIG. 2b shows a longitudinal sectional view of the injection device according to FIG. 2a, the longitudinal sectional view corresponding to the section line BB drawn in FIG. 2e.
  • the multi-part piston rod (8, 9) comprises the click sleeve (9) and the ejection element (8).
  • the click sleeve holding member (9a) provided on the click sleeve (9), particularly the click sleeve holding arm (9a) is shown in FIG Engagement with the click-sleeve-has counter element (8d) arranged on the ejection element (8), in particular with the ejection element recess (8d).
  • the click sleeve (9) is rotatably and / or axially fixed relative to the ejection element (9).
  • the metering stop (2) is configured such that the click sleeve holding member can be held in engagement with the kick sleeve holding counter member.
  • the click sleeve holding member (9a), particularly the click sleeve holding arm (9a) is resiliently biased into engagement with the click sleeve holding counter member (8d), particularly with the Ausstosselementaussparung (8d) held by means of a shell inner surface of Dosierstopps (2).
  • Ejection element stop (8a) of the ejection element (8) is in abutting contact with the dosing stop stop surface (2h) arranged on the inner surface of the dosing stop (2).
  • the multi-part piston rod (8, 9) in particular the click sleeve (9) and the ejection element (8) releasably connected to the metering stop (2), the two Aushetteshülsenhaltearme (5g) of the trigger sleeve (5) are in engagement with the both holding needle grooves (7b) of the holding needle (7).
  • the holding needle (7) is provided with a preloaded spring (12) which is supported at the distal end on the retaining needle stop (7a) of the retaining needle (7) and at the proximal end on the Ausletteshülsenabstütz derivative (5e) of the trigger sleeve (5) with an in apply force to the distal direction.
  • Retaining needle stopper (7a) of the holding needle (7) is of click sleeve inner surface (9c) of the click sleeve (9) and the click sleeve outer surface (9d) of the click sleeve (9) is of the ejection element inner surface (8f) of the ejection element (9 ) spaced.
  • the Ausl Harborhülsenschnapparm (5d) of the trigger sleeve (5) is in the distal
  • Trigger button recess (6b 1 ) arranged.
  • the sliding sleeve edge (3b) of the sliding sleeve (3) is detachably supported in the distal direction on the distal housing stop (1c) of the housing (1) and the
  • Sliding sleeve snap arm (3c) of the sliding sleeve (3) is axially in the proximal direction on the
  • Dosing stop lock stop (2e) of the dosing stop (2) releasably supported.
  • the cartridge holder (10) is engaged with the housing (1) via the threaded connection between the cartridge holder male thread (10a) and the housing internal thread (1e).
  • Carpal holder edge (10e) is spaced from the Schiebehüisekante (3b) of the sliding sleeve (3).
  • the sliding sleeve locking wings (3d ") of the sliding sleeve (3) are located on the
  • corresponding letter or other corresponding character of the carpule holder (10) is such by the on the housing (1) provided housing window (1f) can be seen that the user is displayed that the injection device is in the starting position. Further, the Karpulenhalterrastarm (11c) of the carpule holder (11) in a housing opening (1h) of the housing (1), in particular in a arranged at the distal end of the injection device housing opening (1h) of the housing (1) engaged.
  • FIG 3 is a longitudinal sectional view of the injection device of Figure 1 in the first state in which the multi-part piston rod (8, 9) with the Dosierstopp (2) is detachably connected, and shown in a mixed position in which the solvent from a second chamber (11c) has been diverted into a first chamber (11 d) of a carpule (11).
  • Cartridge holder a hypodermic needle (not shown) can be placed.
  • the carpule holder (10) received by the carpule (11) is introduced into the interior of the housing (1) in the proximal direction relative to the housing (1). This is the carpule holder (10) via the threaded connection between the Karpulenhalteraussengewinde (10 a) and
  • the driving force is transmitted to the first plug (11b) by the solvent in the second chamber (11c), so that both plugs (11b, 11d) are driven distally.
  • the first plug (11b) comes to rest in the area of the bypass (11e) of the carpule (11)
  • the first plug (11b) remains at rest relative to the carpule (11)
  • the second plug (11d) remains stationary is further driven, so that the solvent from the second chamber (11c) via the bypass (11e) in the first chamber (11a) passes and can solve a drug located there.
  • the second plug (11 d) is driven until it hits the first plug (11 b). This achieves the blended position.
  • the carpule holder (10) continues to be inserted or screwed into the housing (1).
  • corresponding letter or other corresponding character of the carpule holder (10) is such by the on the housing (1) provided housing window (1f) can be seen that the user is displayed that the injection device is in the mixed position. Further, the Karpulenhalterrastarm (11c) of the carpule holder (11) in a housing opening (1h) of the housing (1), in particular in an arranged between the distal end and proximal end of the injection device housing opening (1h) of the housing (1) engaged.
  • FIG. 4a is a longitudinal sectional view of the injection device of Figure 1 in the first state in which the multi-part piston rod (8, 9) with the Dosierstopp (2) is detachably connected, and in a primed position in which the injection device is vented, represented, wherein the longitudinal sectional view corresponds to the drawn in Figure 2d section line AA.
  • FIG. 4b shows a longitudinal sectional view of the injection device according to FIG. 4a, the longitudinal sectional view corresponding to the section line BB drawn in FIG. 2e. From the blended position according to FIG. 3, the carpule holder (10) is further inserted or screwed into the housing (1) in the proximal direction.
  • the sliding-fence blocking flights arrive!
  • the two plugs (11b, 11d) are displaced further along the distal direction in the housing 11.
  • the injection needle (not shown) can therefore be used to escape superfluous air from the first chamber 11a the carpule (11) and the carpule holder (10) or between the carpule holder (10) and the Housing (1) reduced or even eliminated! to ensure safe and accurate administration of the fluid product.
  • FIG 5a is a longitudinal sectional view of the injection device of Figure 1 in the first state in which the multi-part piston rod (8, 9) with the Dosierstopp (2) is detachably connected, and shown in a dose position, the longitudinal sectional view of 2d drawn section line AA corresponds.
  • the user rotates the adjustment sleeve (4) relative to the housing (1) and metering stop (2) until the corresponding dose marker of the dose indicator (not shown) of the adjustment knob (4) is replaced by the housing (1 ) provided housing dose window (1i) is visible.
  • the triggering sleeve (5), trigger button (6), retaining needle (7), ejection element (8), click sleeve (9) and the spring (12) are also rotated relative to the housing (1) and the metering stop (2) ,
  • the Ausstossele ment stop (8a) of the ejection element (8) comes out of abutment with the arranged on the inner surface of the Dosierstopps (2) Dosierstoppanschlags behavior (2h).
  • Ejection stop stop notch (8b) of Ausstosselementanschlags (8a) comes to rest in the axial alignment with the Dosierstopp operationsrippe ( Figure 8a, 2j) of Dosierstopps (2).
  • the length of the metering stop guide rib ( Figure 8a, 2j) corresponds to the dose to be administered.
  • the trigger button edge (6e) of Auslettesknope operationslasche (6d) of the Austettesknopfs (6) out of abutment with the Dosierstoppkante (2f) of the wide Dosing stop blocking rib (2g ') of dosing stop (2) Further comes the
  • FIG 6a is a longitudinal sectional view of a proximal part of the injection device of Figure 1 in the first state in which the multi-part piston rod (8, 9) with the Dosierstopp (2) is detachably connected, and shown in a dose-triggered position, wherein the Longitudinal sectional view of the drawn in Figure 2e section line BB corresponds.
  • the user presses the trigger button (6) by means of, for example, a thumb relative to the housing (1) in the distal direction.
  • the release sleeve snap arm (5d) of the release sleeve (5) then passes into the proximal release button recess (6b ") of the release button (6).
  • the two trigger button recesses (6f) of the trigger button (6) are disengaged via the two trigger sleeve retaining arms (5g) of the trigger sleeve (5) such that the trigger sleeve retaining arm (5g), particularly the two trigger sleeve retaining arms (5g), disengage the trigger sleeve (5) 7b), in particular the two holding needle grooves (7b) of the holding needle (7)
  • the holding needle (7) acted upon by the force of the spring (12) is moved relative to the housing (1) in FIG the distal direction moves until the retaining needle stop (7a) of the retaining needle (7) comes into abutting contact with the click sleeve inner surface (9c) of the click sleeve (9) generates a noise that indicates that the injection has begun.
  • FIG. 7 a shows a longitudinal sectional view of a proximal part of the injection device from FIG. 1 in a second state, in which the multi-part piston rod (8, 9) with the metering stop (2) is released, and the click sleeve (9) of FIG Ausstosseiement (8) is releasable and is mounted axially movable relative to the Ausstosseiement (8), wherein the longitudinal sectional view of the drawn in Figure 2d section line AA corresponds.
  • the ejection member (8), the click sleeve (9) and the holding tooth move! (7) axially relative to the housing (1) and the Dosierstopp (2).
  • the first (11a) and the second plug (11d) are pushed in the distal direction.
  • the first plug (11b) can squeeze out the fluid product via the injection needle (not shown) attached to the carpule holder (10).
  • the elastically biased click sleeve holding element (9a) in particular the click sleeve holding arm (9a)
  • the click sleeve holding member (9a) in particular the click sleeve holding arm (9a
  • the click sleeve holding member (9a) in particular the click sleeve holding arm (9a) elastically relaxed in the Dosierstoppaussparung (2n) of Dosierstopps (2).
  • the click sleeve (9) is detachable from the Ausstosseiement (8) and is mounted axially movable relative to the Ausstosseiement (8). Further, as shown in Figure 8a and Figure 8b, by the axial relative movement of the ejection element (8) to the metering stop (2), the ejection element stop (8a) of the ejection element (8) moves in the distal direction, with the ejection element stop notch (Fig. 8b) of
  • the user has set and distributed a medium dose.
  • the Ausstosseiement (8) and the Kückhülse (9) of the Dosierstopp (2) in particular the Ausstosselementan Kunststoff (8a) of the Ausstosselements (8) except
  • the click sleeve holding member (9a) or the click sleeve holding arm (9a) engage with the click sleeve counter element (8d) or the ejection element recess (8d), in particular engage with the two click sleeve counter elements (8d) or both Ejection element recesses (8d) are held.
  • the click sleeve holding member (9a) or the click sleeve holding arm (9a), in particular the two click sleeve holding members (9a) or the two click sleeve holding arms (9a) may be disengaged from the click sleeve counter member (9a). 8d) or the
  • Ausstosselementaussparung (8 d) in particular out of engagement with the two click sleeve counter-elements (8 d) or the two Ausstosselementaussparungen (8 d), wherein the click sleeve holding member (9 a) or the click sleeve holding arm (9 a), in particular the two click sleeve holding elements ( 9a) or the two click sleeve holding arms (9a) in the dose corresponding to the set dose, for example, in the medium dose corresponding Dosierstophariussparung (2n), or in particular in the dose corresponding to the set dose stop openings (2n) protrude or snap.
  • Dosierstoppaussparung (2n), in particular the multiple Dosierstoppaussparonne (2n) of Dosierstopps (2) are so relative to the click sleeve holding member (9a) or the click sleeve holding arm (9a), in particular to the two click sleeve holding elements (9a) or the two click sleeve attachment arms (9a) arranged after the
  • the click sleeve holding member (9a) or the click sleeve holding arm (9a), in particular the two click sleeve holding elements (9a) or the two click sleeve holding arms (9a) in the set dose appropriate
  • FIG. 7b shows a longitudinal sectional view of a proximal part of the injection device from FIG. 1 in the second state, in which the multi-part piston rod (8, 9) is released from the metering stop (2), and the click sleeve (9) of FIG Ejection element (8) is releasable and relative to the ejection element (8) is axially movable, such that the click sleeve is in abutment with the ejection element tangible, and the click sleeve outer surface (9d) of the click sleeve (9) in abutting contact with the ejection element inner surface (8f) of the ejection element (8), the longitudinal sectional view corresponding to the section line AA drawn in FIG. 2d.
  • the click sleeve (9) of the ejection element (8) releasably and axially movable relative to the ejection element (8) until the click sleeve (9) is in abutting contact with the ejection element (8).
  • the click sleeve (9) acted upon by the force of the spring (12) is moved in the distal direction relative to the housing (1) until the click sleeve outer surface (9d) of the click sleeve (9) is in abutting contact with the ejection element inner surface (8f) of the ejection element (8) passes.
  • an acoustic noise is generated, which indicates that the injection process, in particular the discharge has ended.
  • FIG 9 is an exploded view of a second embodiment of an inventive
  • the injection device differs from the injection device of the first embodiment substantially only with respect to the embodiment and with respect to the
  • the injection device further comprises a holding element (13), wherein the carpule (11 ') can be kept free of play by means of holding element (13) on or in the carpule holder (10') by the carpule (11 ').
  • the housing (1) may comprise a housing web (1k), preferably a plurality of housing webs (1k), which may engage with a carpule holder guide groove (not shown) disposed on the carpule holder (10)
  • the carpule holder (10 ') comprises a carpule holder housing (10g), in which a recess (10f) for receiving a projection (13a) and a cam (13b) of the holding element (13) is arranged.
  • the holding element (13) is elastically deformable.
  • the holding element (13) comprises a spring element (13c) on which the projection (13a) and a clamping element (13d) are provided.
  • the holding element (13) has a ring element (13e), which comprises a first spring seat (13f), a second spring seat (3g), a plurality of brackets (13h) and a plurality of connecting webs (13i), wherein the first spring seat (13f) over the a plurality of brackets (13h) and via the plurality of connecting webs (131) with the second spring seat (13g) is connected.
  • the Halteelemeni (13) in the carpule holder (10) is inserted.
  • the projection (13a) of the holding element (13) projects into the recess (8c) of the carpule holder housing (8d) of the carpule holder (10).
  • the cam (13b) of the holding element (13) is radially elastically biased on the inner surface of the shell of the carpule holder (10).
  • the holding element (13) is mounted elastically relaxed in the axial direction in the carpule holder (10).
  • the brackets (13h) are connected to one another via connecting webs (13i) and are fastened via connecting webs (13i) to the first (9f) or to the second spring seat (13g).
  • the Haiteelement (13) is such in the
  • Cartridge holder (10) used that a carpule (11 ') in the carpule holder (10'), in particular in the carpule holder housing (10g) of the carpule holder (10 ') can be inserted.
  • the carpule (11 ') is pushed into the carpule holder (10') through a proximal opening of the carpule holder housing (10g) of the carpule holder (10 ').
  • the distal end of the carpule (11 ') may be in axial abutting contact with the distal end of the carpule holder housing (10g) of the carpule holder (10').
  • the holding element (13) is arranged in an annular gap between the carpule holder (10 ') and the carpule (11').
  • the clamping element (13d) of the spring element (13c) of the holding element (13) protrudes in the proximal direction over a proximal carpule edge (11f) of the carpule (11 ').
  • an axial force in the distal direction can act on the second spring seat (13g) of the holding element (13) such that the holding element (13) is elastic biased and relative to the Karpulenhaltergephaseuse (10g) of the Karpulenhaiters (10 ') is displaced in the axial direction.
  • the projection (13a) of the holding element (9) thereby comes out of engagement with the recess (1 Qf) of the Karpulenhaiters (10 '), wherein the cam (13b) of the holding element (13) in engagement with the recess (13c) of the Karpulenhaiters (13c) 10 ') comes.
  • the spring element (13c) of the holding element (13) is biased radially inwardly so that the clamping element (13d) of the holding element (13) holds or engages around the proximal carpule edge (11f) of the carpule (11 ').
  • the carpule (1 ') is supported at the distal end on or in the carpule holder (10') and at the proximal end on the holding element (13), in particular on the clamping element (13d) of the holding element (13) without play.
  • the carpule holder (10 ') used with the carpule (11') can now be connected to the housing (V) of the
  • a sliding sleeve (3) is already arranged in the housing (1 ') in a proximal position.
  • the sliding sleeve (3) is arranged axially fixed relative to the housing (1 ').
  • the housing guide bar (1j) of the housing (1 ') is engaged with a carpule holder guide groove (not shown) of the cartridge holder (10').
  • the carpule holder (10 ') can be glued or welded to the housing (1') of the injection device.
  • the carpule holder (10 ') may have a carpule holder web, preferably a plurality of carpule holder webs extending in the axial direction, of injection molding device (1k) of the housing (V) of the injection device. between which adhesive or an alternative fastener is applied or inserted Alternatively, on the carpule holder (10 ')
  • Karpulenhalterstege and on the housing (V) of the injection device housing webs (6e) may be provided.
  • FIG. 11 a shows a perspective view of a third embodiment of an injection device according to the invention in a first state, in which a multi-part piston rod (8 ', 9') is releasably connected to a metering stop (not shown), and in an initial position, in which the Injection device is delivered, wherein only the multi-part piston rod (8 ', 9'), a holding needle (7 '), a spring (12') and a holding sleeve (14) are visible.
  • 11b shows a partial view as a longitudinal section of the injection device according to FIG. 11a, whereby likewise only the multi-part piston rod (8 ', 9'), the holding needle (11 '), the spring (12') and the holding sleeve (14) can be seen.
  • the injection device distinguishes of the injection device of the first embodiment substantially only with respect to the
  • the ejection element (8 ') has, instead of the click sleeve retaining counter element (8d), in particular the Ausstosselementaussparung (8d) a
  • the click sleeve (9 ') has, instead of the click sleeve holding member (9d), in particular the click sleeve holding arm (9a), a click sleeve guide member (9f), a Kück sleeve guide surface (9g) and a click sleeve groove (not shown) on.
  • the dosing stop (not shown) does not include dosing stop recesses (2n) and none
  • the injection device comprises a holding sleeve (14) which has a holding sleeve rib (14a).
  • the click-stroke guide element (9f) of the click-sleeve (9 ') the click-eye-surface (9g) is arranged.
  • the ejection element guide surface (8 d) of the Ausfosselements (8 ') and the click sleeve guide surface (9 g) of the click sleeve (9') are formed so that they have a
  • the ejection element guide surface (8d) and the click sleeve guide surface (9g) may be formed as cooperating screw portion-shaped guide surfaces.
  • the kick sleeve (9 ') is rotatably disposed relative to the ejection element (8').
  • the cooperating guide slot of the outfeed element (8 ') and the click sleeve (9'), in particular the ejection element guide surface (8h) and the click sleeve guide surface (9g) are designed such that a relative rotational movement between the ejection element (8 ') and the Click element (9 ') can be effected.
  • the ejection element guide recess (8g) of the detection member ( ⁇ ') is formed so as to receive the click sleeve guide member (9f) of the click sleeve (9').
  • Ejection element guide recess (8g) is arranged in the circumferential direction of the Ausfosselements (8 ') offset from the Ausstosselement Adjusts St (8d).
  • the retaining sleeve (13) is arranged axially movably on the proximal end of the outer element (8) and the click sleeve (9 ').
  • the retaining sleeve rib (14a) of the retaining sleeve (14) is configured to cooperate with the ejection element engagement groove (8b ') of the ejection element stop (8a') and the click-sleeve groove (not shown) located at the proximal end.
  • Sheath sleeve rib (14a) is engaged with the ejection element engaging notch (8b ') of the sensing element (8') and engaging the click sleeve groove (not shown) of the click sleeve (9 ').
  • the distal end of the retaining sleeve rib (14a) projects beyond the distal end of the ejection element stop (8a ').
  • the holding needle (?) Is acted upon by a force acting in the distal direction of a spring.
  • FIG. 12 shows a partial view as a longitudinal section of the injection device of the third embodiment of an injection device according to the invention in the first state in which the multi-part piston rod (8 ', 9') is releasably connected to the metering stop (not shown) and in one dose triggered position.
  • a release button (not shown) by, for example, a thumb relative to a housing (not shown) of the injection device in the distal direction.
  • the holding needle (7 ') by a release sleeve (not shown) of the injection device can be released.
  • the holding needle (7 ') acted upon by the force of the spring (12') can be moved in the distal direction relative to the housing (not shown) until the holding needle stop (7a ') of the holding needle (7') is in abutting contact with the click - Sleeve inner surface (9 c ') of the click sleeve (9) passes.
  • the force of the spring (12 1 ) acts on the click sleeve (9 ').
  • FIG. 13 a shows a perspective view of the third embodiment of an injection device according to the invention in a second state, in which the multi-part piston rod (8 ', 9') is released from the metering stop (not shown), and the click sleeve (9 ').
  • FIG. 13b shows a partial view as a longitudinal section of the injection device according to FIG.
  • the Ausstosselementanschiag (8a') of the ejection element (8 ') moves in the distal direction until the Ausstosselementanschiag (8a') of the ejection element (8 ') in stop contact with one of the set dose corresponding Dosierstoppanschlag (not visible) of a Dosierstopptreppenglieds (not visible) of Dosierstopps (not visible) passes.
  • the holding sleeve (14) shifts axially relative to the ejection element (8 ') in the proximal direction until the distal end of the retaining sleeve rib (14a) is arranged flush with the distal end of the Ausstosselementanschlags (8a).
  • the retaining sleeve rib (14a) disengages from the click-sleeve groove (not shown). Due to the force acting on the click sleeve (9 ') of the spring (12') and the cooperating guide slot between the click sleeve (9 ') and the ejection element (8'), the click sleeve (9 ') relative Turn to the ejection element (8 ').
  • the click sleeve guide surface (9g) of the click sleeve (9 ') moves relative to the ejection element guide surface (8h) of the ejection element (8') until the clip sleeve guide member (9f) slides over the Ejection element guide recess (8g) passes.
  • the force of the spring (12) then causes the click sleeve guide member (9f) to be moved in the distal direction into the ejection element guide recess (8g). As shown in FIG.

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

La présente invention concerne un dispositif d'injection permettant le dosage et la distribution d'une dose d'un produit fluide, comprenant un boîtier (1; 1') doté de plusieurs butées ou un élément d'arrêt de dosage (2) relié fixement au boîtier (1; 1') et doté de plusieurs butées (2Ι', 2I", 2I"'), notamment de plusieurs butées d'arrêt de dosage (2Ι', 2I", 2I"'), le dispositif d'injection présentant une tige de piston (8, 9, 8', 9') en plusieurs parties qui peut être détachée du boîtier (1; 1') ou qui peut être détachée de l'élément d'arrêt de dosage (2) relié fixement au boîtier (1; 1'), la tige de piston (8, 9, 8', 9') en plusieurs parties comprenant un manchon à clic (9, 9') et un élément d'éjection (8, 8').
PCT/CH2017/000009 2016-02-25 2017-02-02 Dispositif d'injection permettant le dosage et la distribution d'une dose définie d'un produit fluide WO2017143461A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH00247/16 2016-02-25
CH00247/16A CH710381A2 (de) 2016-02-25 2016-02-25 Injektionsvorrichtung zur Aufdosierung und zur Ausschüttung einer Dosis eines fluiden Produkts.

Publications (1)

Publication Number Publication Date
WO2017143461A1 true WO2017143461A1 (fr) 2017-08-31

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PCT/CH2017/000009 WO2017143461A1 (fr) 2016-02-25 2017-02-02 Dispositif d'injection permettant le dosage et la distribution d'une dose définie d'un produit fluide

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CH (1) CH710381A2 (fr)
WO (1) WO2017143461A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109172948A (zh) * 2018-10-16 2019-01-11 甘肃成纪生物药业有限公司 一种剂量调节保险限位机构
TWI670097B (zh) * 2018-10-24 2019-09-01 群康生技股份有限公司 具有注射劑量調整功能的注射器
CN111544706A (zh) * 2020-05-11 2020-08-18 易舒康(山东)生物科技有限公司 一种剂量准确的便携无针注射器
JP2021520910A (ja) * 2018-04-13 2021-08-26 ハーゼルマイアー アーゲー 薬剤送達装置
CN113747932A (zh) * 2019-05-07 2021-12-03 益首药物治疗股份公司 用于注射装置的配量设备

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1633417A1 (fr) * 2003-05-30 2006-03-15 Eli Lilly And Company Appareil de distribution de medicament a chambres multiples
WO2006057604A1 (fr) * 2004-11-24 2006-06-01 Shl Medical Ab Dispositif d'injection
WO2013178512A1 (fr) 2012-05-31 2013-12-05 Carebay Europe Ltd Dispositif de délivrance de médicament
US8821451B2 (en) 2010-03-31 2014-09-02 Shl Group Ab Medicament delivery device

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1633417A1 (fr) * 2003-05-30 2006-03-15 Eli Lilly And Company Appareil de distribution de medicament a chambres multiples
WO2006057604A1 (fr) * 2004-11-24 2006-06-01 Shl Medical Ab Dispositif d'injection
US8821451B2 (en) 2010-03-31 2014-09-02 Shl Group Ab Medicament delivery device
WO2013178512A1 (fr) 2012-05-31 2013-12-05 Carebay Europe Ltd Dispositif de délivrance de médicament

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021520910A (ja) * 2018-04-13 2021-08-26 ハーゼルマイアー アーゲー 薬剤送達装置
JP7300463B2 (ja) 2018-04-13 2023-06-29 メドミクス スウィッツァランド アーゲー 薬剤送達装置
CN109172948A (zh) * 2018-10-16 2019-01-11 甘肃成纪生物药业有限公司 一种剂量调节保险限位机构
TWI670097B (zh) * 2018-10-24 2019-09-01 群康生技股份有限公司 具有注射劑量調整功能的注射器
CN113747932A (zh) * 2019-05-07 2021-12-03 益首药物治疗股份公司 用于注射装置的配量设备
CN113747932B (zh) * 2019-05-07 2023-09-05 益首药物治疗股份公司 用于注射装置的配量设备
CN111544706A (zh) * 2020-05-11 2020-08-18 易舒康(山东)生物科技有限公司 一种剂量准确的便携无针注射器

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