WO2017070012A1 - Lapachone derivatives containing two redox centers and methods of use thereof - Google Patents

Lapachone derivatives containing two redox centers and methods of use thereof Download PDF

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Publication number
WO2017070012A1
WO2017070012A1 PCT/US2016/056986 US2016056986W WO2017070012A1 WO 2017070012 A1 WO2017070012 A1 WO 2017070012A1 US 2016056986 W US2016056986 W US 2016056986W WO 2017070012 A1 WO2017070012 A1 WO 2017070012A1
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WO
WIPO (PCT)
Prior art keywords
alkyl
hydrogen
substituted
compound
aryl
Prior art date
Application number
PCT/US2016/056986
Other languages
English (en)
French (fr)
Inventor
David A. Boothman
Eufranio N. DA SILVA JUNIOR
Eduardo H.g. DA CRUZ
Bruno C. CAVALCANTI
Antonio L. BRAGA
Claudia PESSOA
Molly SILVERS
Original Assignee
The Board Of Regents Of The University Of Texas System
Universidade Federal Do Ceara
Universidade Federal De Minas Gerais
Universidade Federal De Santa Catarina
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Board Of Regents Of The University Of Texas System, Universidade Federal Do Ceara, Universidade Federal De Minas Gerais, Universidade Federal De Santa Catarina filed Critical The Board Of Regents Of The University Of Texas System
Priority to BR112018008076-4A priority Critical patent/BR112018008076B1/pt
Publication of WO2017070012A1 publication Critical patent/WO2017070012A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/92—Naphthofurans; Hydrogenated naphthofurans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
PCT/US2016/056986 2015-10-20 2016-10-14 Lapachone derivatives containing two redox centers and methods of use thereof WO2017070012A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BR112018008076-4A BR112018008076B1 (pt) 2015-10-20 2016-10-14 Derivados de lapachona contendo dois centros redox e métodos de uso dos mesmos

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562244038P 2015-10-20 2015-10-20
US62/244,038 2015-10-20

Publications (1)

Publication Number Publication Date
WO2017070012A1 true WO2017070012A1 (en) 2017-04-27

Family

ID=58558234

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2016/056986 WO2017070012A1 (en) 2015-10-20 2016-10-14 Lapachone derivatives containing two redox centers and methods of use thereof

Country Status (2)

Country Link
BR (1) BR112018008076B1 (pt)
WO (1) WO2017070012A1 (pt)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109020986A (zh) * 2018-08-28 2018-12-18 中南大学 喹啉醌并氧杂环衍生物及其制备方法和在抗肿瘤药物上的应用
CN109705095A (zh) * 2019-02-25 2019-05-03 山东大学 一种含三氮唑环的稠环对苯醌类cdc25蛋白磷酸酶抑制剂及其制备方法和应用
CN113368087A (zh) * 2020-03-10 2021-09-10 复旦大学附属华山医院 胡桃醌其衍生物及其在制备化疗脑肿瘤的药物中的用途
CN115215837A (zh) * 2022-06-29 2022-10-21 山东大学 一种含三氮唑环的稠环对苯醌类二聚体衍生物及其制备方法与应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5969163A (en) * 1996-02-20 1999-10-19 Wisconsin Alumni Research Foundation Ortho-quinone derivatives, novel synthesis therefor, and their use in the inhibition of neoplastic cell growth
WO2008066301A1 (en) * 2006-11-27 2008-06-05 Mazence Inc. Anticancer composition containing naphthoquinone-based compound for intestine delivery system
US20140161720A1 (en) * 2011-05-26 2014-06-12 The General Hospital Corporation Treatment of angiogenic- or vascular-associated diseases

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5969163A (en) * 1996-02-20 1999-10-19 Wisconsin Alumni Research Foundation Ortho-quinone derivatives, novel synthesis therefor, and their use in the inhibition of neoplastic cell growth
WO2008066301A1 (en) * 2006-11-27 2008-06-05 Mazence Inc. Anticancer composition containing naphthoquinone-based compound for intestine delivery system
US20140161720A1 (en) * 2011-05-26 2014-06-12 The General Hospital Corporation Treatment of angiogenic- or vascular-associated diseases

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE PUBCHEM. 26 March 2005 (2005-03-26), XP055377659, Database accession no. 8530. *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109020986A (zh) * 2018-08-28 2018-12-18 中南大学 喹啉醌并氧杂环衍生物及其制备方法和在抗肿瘤药物上的应用
CN109705095A (zh) * 2019-02-25 2019-05-03 山东大学 一种含三氮唑环的稠环对苯醌类cdc25蛋白磷酸酶抑制剂及其制备方法和应用
CN109705095B (zh) * 2019-02-25 2021-06-08 山东大学 一种含三氮唑环的稠环对苯醌类cdc25蛋白磷酸酶抑制剂及其制备方法和应用
CN113368087A (zh) * 2020-03-10 2021-09-10 复旦大学附属华山医院 胡桃醌其衍生物及其在制备化疗脑肿瘤的药物中的用途
CN115215837A (zh) * 2022-06-29 2022-10-21 山东大学 一种含三氮唑环的稠环对苯醌类二聚体衍生物及其制备方法与应用

Also Published As

Publication number Publication date
BR112018008076A2 (pt) 2018-10-23
BR112018008076B1 (pt) 2024-03-12

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