WO2017039316A8 - 생체 내 폐조직 미세영상 획득을 위한 미세흡인 기반 폐 원도우 장치 및 이를 이용한 영상 획득 방법 - Google Patents

생체 내 폐조직 미세영상 획득을 위한 미세흡인 기반 폐 원도우 장치 및 이를 이용한 영상 획득 방법 Download PDF

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Publication number
WO2017039316A8
WO2017039316A8 PCT/KR2016/009720 KR2016009720W WO2017039316A8 WO 2017039316 A8 WO2017039316 A8 WO 2017039316A8 KR 2016009720 W KR2016009720 W KR 2016009720W WO 2017039316 A8 WO2017039316 A8 WO 2017039316A8
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WO
WIPO (PCT)
Prior art keywords
obtaining
image
lung tissue
lung
microaspiration
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Application number
PCT/KR2016/009720
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English (en)
French (fr)
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WO2017039316A1 (ko
Inventor
김필한
박인원
김성훈
Original Assignee
재단법인 의약바이오컨버젼스연구단
한국과학기술원
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Application filed by 재단법인 의약바이오컨버젼스연구단, 한국과학기술원 filed Critical 재단법인 의약바이오컨버젼스연구단
Priority to CN201680062597.XA priority Critical patent/CN108601555B/zh
Priority to US15/756,478 priority patent/US10437035B2/en
Priority to JP2018530459A priority patent/JP6630831B2/ja
Priority to EP16842282.2A priority patent/EP3345546B1/en
Publication of WO2017039316A1 publication Critical patent/WO2017039316A1/ko
Publication of WO2017039316A8 publication Critical patent/WO2017039316A8/ko

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    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G02B21/362—Mechanical details, e.g. mountings for the camera or image sensor, housings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
    • A61B5/0803—Recording apparatus specially adapted therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6886—Monitoring or controlling distance between sensor and tissue
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/0012—Surgical microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G02B21/361—Optical details, e.g. image relay to the camera or image sensor

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Analytical Chemistry (AREA)
  • Optics & Photonics (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Physiology (AREA)
  • Pulmonology (AREA)
  • Multimedia (AREA)
  • Microscoopes, Condenser (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

본 발명은 생체 내 폐조직 미세영상 획득을 위한 미세흡인 기반 폐 원도우 장치 및 이를 이용한 영상 획득 방법을 개시한다. 본 발명의 일 실시예에 따르면, 상하부가 개방되며, 상부에 커버 글라스가 배치되고 하부에 폐조직이 접촉되는 개 방창, 상기 개방창의 일측에서부터 흡인장치로 연장되어 상기 개방창 내부가 진공 상태가 되도록 하는 흡인관 및 상기 개방창의 일측으로부터 연장되며, 상기 커버 글라스와 공초점 현미경 시스템의 대물렌즈가 평행한 상태를 유지하도록 하는 틸팅 마운트가 안착되는 틸팅 마운트 안착부를 포함하는 폐 원도우 장치가 제공된다. 본 실시예에 따르면, 동물의 호흡 및 순환을 생리적으로 유지하고 이에 간섭을 주지 않으면서 동시에 생체 내 폐조직의 세포 및 분자 수준 미세영상을 안정적으로 획득 할 수 있는 장점이 있다.
PCT/KR2016/009720 2015-08-31 2016-08-31 생체 내 폐조직 미세영상 획득을 위한 미세흡인 기반 폐 원도우 장치 및 이를 이용한 영상 획득 방법 WO2017039316A1 (ko)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CN201680062597.XA CN108601555B (zh) 2015-08-31 2016-08-31 一种获取活体内肺组织显微影像的基于微量吸入的肺窗装置及利用其获取影像的方法
US15/756,478 US10437035B2 (en) 2015-08-31 2016-08-31 Microaspiration-based lung window apparatus for obtaining microscopic image of in vivo lung tissue and method for obtaining image using same
JP2018530459A JP6630831B2 (ja) 2015-08-31 2016-08-31 生体内肺組織の顕微鏡イメージを取得するための微小吸引型肺ウィンドー装置及びそれを用いたイメージ取得方法
EP16842282.2A EP3345546B1 (en) 2015-08-31 2016-08-31 Microaspiration-based lung window apparatus for obtaining microscopic image of in vivo lung tissue

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2015-0123216 2015-08-31
KR1020150123216A KR101743283B1 (ko) 2015-08-31 2015-08-31 생체 내 폐조직 미세영상 획득을 위한 미세흡인 기반 폐 윈도우 장치 및 이를 이용한 영상 획득 방법

Publications (2)

Publication Number Publication Date
WO2017039316A1 WO2017039316A1 (ko) 2017-03-09
WO2017039316A8 true WO2017039316A8 (ko) 2018-03-22

Family

ID=58188002

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2016/009720 WO2017039316A1 (ko) 2015-08-31 2016-08-31 생체 내 폐조직 미세영상 획득을 위한 미세흡인 기반 폐 원도우 장치 및 이를 이용한 영상 획득 방법

Country Status (6)

Country Link
US (1) US10437035B2 (ko)
EP (1) EP3345546B1 (ko)
JP (1) JP6630831B2 (ko)
KR (1) KR101743283B1 (ko)
CN (1) CN108601555B (ko)
WO (1) WO2017039316A1 (ko)

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* Cited by examiner, † Cited by third party
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Also Published As

Publication number Publication date
EP3345546B1 (en) 2023-10-04
CN108601555B (zh) 2021-01-29
JP6630831B2 (ja) 2020-01-15
KR20170025998A (ko) 2017-03-08
US20180246311A1 (en) 2018-08-30
US10437035B2 (en) 2019-10-08
EP3345546C0 (en) 2023-10-04
EP3345546A4 (en) 2019-05-29
KR101743283B1 (ko) 2017-06-02
WO2017039316A1 (ko) 2017-03-09
CN108601555A (zh) 2018-09-28
EP3345546A1 (en) 2018-07-11
JP2018526688A (ja) 2018-09-13

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WO2017039316A8 (ko) 생체 내 폐조직 미세영상 획득을 위한 미세흡인 기반 폐 원도우 장치 및 이를 이용한 영상 획득 방법

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