WO2017036649A1

WO2017036649A1 - Cosmetic o/w emulsions for anti-wrinkle treatment

Info

Publication number: WO2017036649A1
Application number: PCT/EP2016/066528
Authority: WO
Inventors: Soraya Heinen; Ira Hartmann; Marianne Waldmann-Laue; Annika Bähren
Original assignee: Henkel Ag & Co. Kgaa
Priority date: 2015-08-31
Filing date: 2016-07-12
Publication date: 2017-03-09
Also published as: DE102015216610A1

Abstract

Cosmetic or dermatological formulations in the form of an oil-in-water emulsion, comprising a combination of the active ingredients a) – d) as follows: a) 0.01 to 3.00 wt% of at least one C_12-20-alkyl phosphate and/or C_12-20-alkyl phosphate salt, b) 0.01 to 3.00 wt% of at least one – optionally hydrolysed – C_14-20 mono- or diacylglyceride, c) 0.05 to 5.00 wt% of at least one alkyl(oligo)glycoside of the general formula RO-[G]_x, in which R is a saturated alkyl radical having 12 to 24 C atoms, G is a sugar radical having 5 or 6 C atoms and x stands for numbers from 1 to 10, and d) at least one active ingredient for preventing and/or alleviating signs of skin ageing, are suitable for preventing and/or alleviating signs of skin ageing, especially cutaneous wrinkles and/or lines, indications of intrinsic and extrinsic skin ageing, tired and/or loose skin and/or skin damaged by exposure to UV light.

Description

COSMETIC O / W EMULSIONS FOR ANTIFOLD TREATMENT

The invention is in the field of cosmetics and relates to compositions for the cosmetic and topical dermatological anti-wrinkle treatment in the form of an oil-in-water emulsion containing, in addition to a specific combination of emulsifiers, at least one active ingredient for reducing and / or preventing signs of aging.

Means and treatment methods for treating mature and / or intrinsically or extrinsically aged or photodamaged skin, particularly for anti-wrinkle treatment, are a significant cosmetic challenge.

Every movement of our body through the muscles activates micro-contractions of the skin. As a result of their constant repetition, more and more distinct wrinkles are formed over time. This problem is compounded in particular in the second half of life by increasing dehydration of the skin and the progressive transfer of skin cells from a proliferative status to a resting, senescent status. This transition corresponds to aging at the cellular level, to which much of the macroscopic aging effects can be attributed. The number of cells in the tissue decreases and can no longer be filled due to lack of proliferating cells. As a result, repairs of the surrounding tissue can not be performed, defects accumulate, causing the skin to become atrophied and slack.

Preparations for the treatment and reduction of wrinkles are known per se.

Thus, for example, in the European patent application EP 1634576A1 cosmetic

Compositions for the prophylaxis and treatment of skin aging phenomena disclosed which contain at least one DNA repair enzyme and at least one oligopeptide.

German patent application DE 10201421 1205A1 discloses compositions for

Reduction of aging signs of the skin revealing a mixture of different

Contains plant extracts.

However, there is still a need for improved and / or further optimized anti-aging compositions.

The object of the present invention was therefore to provide cosmetic or dermatological oil-in-water emulsions which have a lighter texture than conventional 07W emulsions, which are particularly easy to apply to the skin and rapidly into the skin Feed skin. The emulsions should have very good stability, be very skin-friendly and have an excellent anti-wrinkle effect in three dimensions.

It was another object of the present invention to develop a new, stable and cosmetically effective skin care composition for reducing and / or preventing signs of aging of the skin, particularly wrinkles and / or lines. In particular, the application of the skincare preparation should also increase the skin moisture, elasticity and firmness of the skin.

It has surprisingly been found that the above-mentioned requirements by means of a combination of anionic alkyl phosphene emulsifiers, nonionic mono- or diacylglycerides, alkyl (oligo) glycosides and at least one active ingredient for reducing and / or preventing signs of skin aging in cosmetic O / W emulsions could be fulfilled. By combining at least one emulsifier in the fatty phase (alkyl phosphate, diacylglyceride) and at least one emulsifier in the water phase (alkyl (oligo) glycoside) particularly stable emulsions could be formulated.

A first subject of the invention is therefore a cosmetic or dermatological composition in the form of an oil-in-water emulsion which contains a combination of the following active ingredients a) -d):

a) 0.01 to 3.00 wt .-% of at least one Ci2-2o-Alkylphoshats or a C 12-20- Alkylphoshatsalzes,

b) 0.01 to 3.00% by weight of at least one - optionally hydrolyzed - 04-20 mono- or diacylglyceride,

c) 0.05 to 5.00 wt .-% of at least one alkyl (oligo) glycoside of the general formula RO- [G] x, in the R for a saturated alkyl radical having 12 to 24 carbon atoms, G for a sugar residue with 5 or 6 C atoms and x represents numbers from 1 to 10, and d) at least one active ingredient for reducing and / or preventing signs of aging (anti-aging active substance),

wherein the amounts are based on the total weight of the cosmetic or dermatological composition.

As a first mandatory ingredient, the oil-in-water emulsion according to the invention contain at least one C 12-2o alkyl phosphate or one C 12-2 o alkyl phosphate salt a) in an amount of 0, based on the total weight of the oil-in-water emulsion , 01 to 3.00 wt .-%.

According to preferred Ci2-2o-Alkylphoshate or Ci2-2o-Alkylphoshatsalze, which form an anionic oil-in-water emulsifier, a first part of the invention used O / W emulsifier, are selected from the monoesters of phosphoric acid with Lauryl, tridecyl, isotridecyl, myristyl, pentanoyl Alkanolamine or glucammonium salt, preferably as sodium, potassium, alkanolamine, trialkylammonium, triethanolamine, 2-amino-1-butanol, 2-amino-2-methyl-1-propanol, 2-amino-2 methyl-1, 3-propanediol, 2-amino-2-ethyl-1, 3-propanediol or tris (hydroxymethyl) aminomethane salt and may be present as the salt of the basic amino acids ornithine, lysine, arginine and / or histidine. Preference is given to the potassium salts of said phosphoric acid monoesters.

Particularly preferred is dipotassium monocetyl phosphate.

Further preferred according to the invention Ci2-2o-Alkylphoshate or Ci2-2o-Alkylphoshatsalze, which form as an anionic oil-in-water emulsifier, a first part of the inventive 07W emulsifier system are selected from the diesters of phosphoric acid with lauryl alcohol, tridecyl alcohol, isotridecyl alcohol, Myristyl alcohol, pentadecyl alcohol, cetyl alcohol, palmityl alcohol, isocetyl alcohol, isostearyl alcohol, stearyl alcohol, oleyl alcohol, elaidyl alcohol, linoleyl alcohol, linolenyl alcohol, nonadecyl alcohol, arachyl alcohol, gadoleyl alcohol or arachidonic alcohol, which are alkali metal, alkaline earth metal, ammonium, alkylammonium, alkanolamine or glucammonium salt the corresponding sodium, potassium, alkanolamine, trialkylammonium, triethanolamine, 2-amino-1-butanol, 2-amino-2-methyl-1-propanol, 2-amino-2-methyl-1, 3 propanediol, 2-amino-2-ethyl-1, 3-propanediol or tris (hydroxymethyl) aminomethane salt and as the salt of the basic amino acids ornithine, lysine, arginine and / or H isidine, may be present.

Preference is given to the potassium salts of said phosphoric diesters.

Particularly preferred is potassium dicetyl phosphate.

Very particular preference is given to mixtures of mono-C 12-2o-alkyl phosphates and C 1 -C 20 -alkyl phosphates.

Extremely preferred are mixtures of dipotassium monocetyl phosphate and potassium dicetyl phosphate.

The at least one salt of a C 12-2 o -alkyl phosphate is preferably present in the compositions according to the invention in a total amount of from 0.01 to 3.00% by weight, more preferably from 0.025 to 2.75% by weight, particularly preferably from 0, 05 to 2.50 wt .-%, most preferably from 0.075 to 2.25 wt .-% and in particular from 0, 10 to 2.00 wt .-%, each based on the total weight of the composition.

Particularly preferred compositions according to the invention comprise at least one salt of cetyl phosphate and / or a mixture of dipotassium monocetyl phosphate and potassium dicetyl phosphate in a total amount of from 0.01 to 3.00% by weight, more preferably from 0.025 to 2.75% by weight, particularly preferably from 0.05 to 2.50 wt .-%, most preferably from 0.075 to 2.25 wt .-% and in particular from 0, 10 to 2.00 wt .-%, each based on the total weight of the compositions ,

C4-2o mono- or diacylglycerides which are preferred according to the invention and form the second part of the O / W emulsifier system according to the invention are selected from monomyristoylglyceride, monopalmitoylglyceride, monostearoylglyceride, monoarachinoylglyceride, dimyristoylglyceride, dipalmitoylglyceride, distearoylglyceride and diarachinoylglyceride as well as mixtures thereof. Further inventively preferred Ci4-2o mono- or Diacylglyceridmischungen are glycerides cured, that is, hydrogenated, preferably fully hydrogenated, fatty acids of natural oils. Hardened (hydrolyzed) palm oil glycerides are particularly preferred according to the invention.

The at least one C 1-4 mono or diacylglyceride b) is particularly preferred in the compositions of the present invention in a total amount of from 0.01 to 3.00 wt%, more preferably from 0.02 to 2.60 wt% preferably from 0.03 to 2.30 wt .-%, most preferably from 0.04 to 2.00 wt% and in particular from 0.05 to 1, 70 wt .-%, each based on the total weight of the composition , contain.

Preferred compositions according to the invention contain at least one substance selected from monomyristoylglyceride, monopalmitoylglyceride, monostearoylglyceride, monoarachinoylglyceride, dimyristoylglyceride, dipalmitoylglyceride, distearoylglyceride and diarachinoylglyceride, as well as mixtures thereof, in a total amount of 0.01 to 3.00% by weight, more preferably of 0 , 02 to 2.60 wt .-%, particularly preferably from 0.03 to 2.30 wt .-%, most preferably from 0.04 to 2.00 wt% and in particular from 0.05 to 1.70 Wt .-%, each based on the total weight of the composition.

Further preferred compositions according to the invention contain as Ci4-2o mono- or Diacylglyceridmischungen hardened palm oil glycerides in a total amount of 0.01 to 3.00 wt .-%, more preferably from 0.02 to 2.60 wt .-%, particularly preferably from 0.03 to 2.30 wt .-%, most preferably from 0.04 to 2.00 wt% and in particular from 0.05 to 1, 70 wt .-%, each based on the total weight of the composition.

Further preferred compositions according to the invention comprise the at least one component a) and the at least one component b) in a weight ratio of from 2/3 to 3/2, preferably from 1/1 to 3/2 and particularly preferably from 6/5 to 3/2 ,

Corresponding O / W-emulsifier systems comprising mixtures of Dikaliummonocetylphosphat and Kaliumdicetylphosphat with hardened Palmölglyceriden, are commercially available, for example under the name Emulsiphos ^® 677 660 (INCI name: Potassium Cetyl Phosphate, Hydrogenated Palm Glycerides) from the company Symrise. Their use in the compositions of the invention is particularly preferred. )) Is used for the case where the commercially available product ^® Emulsiphos 677,660 as O / W emulsifier system in the inventive compositions (a) and b, its amount used is from 0.05 to 5.00 wt .-%, more preferably from 0.075 to 4.75% by weight, particularly preferably from 0.10 to 4.50% by weight, very particularly preferably from 0.15 to 4.25% by weight and in particular from 0.20 to 4.00% by weight .-%, each based on the total weight of the compositions.

It has been found that in order to achieve the desired stability in combination with the excellent skin compatibility of the compositions according to the invention, the additional use of a further emulsifier is required.

As a third essential component of the emulsifier system, the compositions according to the invention therefore contain from 0.05 to 5.00% by weight of at least one alkyl (oligo) glycoside of the general formula RO- [G] x in which R is a saturated alkyl radical having 12 to 24 C atoms, G stands for a sugar residue with 5 or 6 C atoms and x stands for numbers from 1 to 10.

Preference is given to alkyl (oligo) glycosides c) of the general formula RO- [G] x, in which R is an alkyl radical having 14 to 20 C atoms, G is a sugar radical having 5 or 6 C atoms and x is numbers of 1 until 10 stands.

Particularly suitable alkyl (oligo) glycosides c) are derived from aldoses and / or ketoses having 5 or 6 carbon atoms, preferably glucose.

The radical R is particularly preferably an alkyl radical having 14, 15, 16, 17, 18, 19, 20 carbon atoms or mixtures of these alkyl radicals.

Particularly preferably, the radical R is a mixture of C ds-alkyl chains ("cetearyl"). The index number x in the general formula RO- [G] x stands for the degree of oligomerization (DP), ie for the distribution of the mono- and oligoglycosides The index number x preferably has a value in the range from 1 to 6, particularly preferably in the range from 1 to 3, which may not be an integer but a fractional number which can be determined analytically Alkyl (oligo) glycosides have a DP between 1.0 to 1.5.

Very particularly suitable alkyl (oligo) glycosides c) are commercially available under the INCI names Cetyl Glucoside in view of their excellent synergistic effect with the O / W emulsifier system (a) and b)) with regard to the stabilization of, in particular, oil-soluble active compounds in the compositions according to the invention , Stearyl glucosides and cetearyl glucosides known compounds. Especially preferred is cetearyl glucoside. In a preferred embodiment, the compositions of the invention contain - based on their total weight - 0.10 to 4.50 wt .-%. preferably 0.25 to 4.00 wt .-%. particularly preferably 0.50 to 3.50% by weight and in particular 0.75 to 3.00% by weight of at least one alkyl (oligo) glycoside of the general formula RO- [G] x in which R is a saturated alkyl radical having 12 to 24 C atoms, G stands for a sugar residue with 5 or 6 C atoms and x stands for numbers from 1 to 10. With particular preference the compositions according to the invention contain at least one alkyl (oligo) glycoside compound known in the INCI name cetearyl glucoside in the abovementioned amounts.

A corresponding commercial product which contains compounds with the INCI name Cetearyl Glucoside is available under the name Tego ^Care® CG 90 from Evonik.

In a very particularly preferred embodiment, agents according to the invention are characterized in that they contain-based on their total weight-a) from 0.025 to 2.75% by weight, preferably from 0.05 to 2.50% by weight, particularly preferably from 0.075 to 2 , 25 wt .-% and in particular 0, 10 to 2.00 wt .-% of at least one salt of a Ci2-2o-Alkylphoshats, preferably a salt of cetyl phosphate,

b) 0.02 to 2.60 wt.%, preferably 0.03 to 2.30 wt.%, particularly preferably 0.04 to 2.00 wt.% and in particular 0.05 to 1.70 wt. -% of at least one - optionally hydrolyzed - Ci4-2o mono- or diacylglyceride, preferably a hydrolyzed Ci5-ie mono- or diacylglyceride and in particular hydrolyzed palm oil glyceride.

c) 0.10 to 4.50 wt .-%. preferably 0.25 to 4.00 wt .-%. particularly preferably 0.50 to 3.50 wt .-% and in particular 0.75 to 3.00 wt .-% of at least one alkyl (oligo) glycoside of the general formula RO- [G] x, in which R is a saturated alkyl radical having 12 to 24 C Atoms, G is a sugar residue with 5 or 6 C atoms and x is a number from 1 to 10, preferably an alkyl (oligo) glycoside known under the INCI name Cetearyl Glucoside, and

d) 0.01 to 10.00 wt .-%, preferably 0.02 to 9.00 wt .-%, preferably 0.03 to 8.00 wt .-%, particularly preferably 0.04 to 7.00 wt % and in particular 0.05 to 6.00 wt .-% of at least one active ingredient for reducing and / or preventing signs of aging of the skin, in particular skin folds and / or lines contains, wherein the amounts are based on the total weight of the composition ,

As a fourth essential component, the compositions according to the invention contain at least active ingredient for reducing and / or preventing signs of skin aging d). This is necessary for the reduction and / or removal and / or smoothing of fine lines to deep wrinkles on the skin. The compositions according to the invention preferably contain the active ingredient for reducing and / or preventing signs of skin aging d) in amounts of 0.02 to 9.00% by weight, preferably 0.03 to 8.00% by weight, particularly preferably 0 , 04 to 7.00 wt .-% and in particular 0.05 to 6.00 wt .-%, wherein the amounts are based on the total weight of the cosmetic or dermatological compositions.

It has been found that certain active ingredients for the reduction and / or prevention of signs of skin aging d) are particularly suitable according to the invention, because they can not only be excellently combined with the emulsifier system a), b), c) and lead to particularly stable on storage In addition, the compositions provide an excellent anti-wrinkle effect and visibly and tactually impart more smoothness and firmness to the treated skin.

Particularly suitable active ingredients for the reduction and / or prevention of signs of skin aging d) are selected from: plant extracts, hyaluronic acid, esters and / or salts of hyaluronic acid, DNA repair enzymes and mixtures of these active substances.

Suitable plant extracts for the purposes of the present invention are substances or substance mixtures which are obtained by extraction and partial or complete evaporation of the extraction solution. A distinction is made according to the nature dry extracts d. H. Extracted to dryness extracts, fluid extracts d. H. extracts prepared with solvents such that at most 2 parts of fluid extract are recovered from one part of the drug, viscous extracts or thick extracts, d. H. Extracts in which part of the solvent is evaporated.

The extracts preferably used according to the invention are obtained from the respective plant parts or mixtures thereof by extraction, preferably with organic solvents, water or mixtures thereof. Preferred organic solvents are ketones (eg acetone), ethers, esters, alcohols or halogenated hydrocarbons. Particularly preferred extractants are water and / or alcohols. Among the alcohols, preference is given to d-CeJ alcohols, such as ethanol and isopropanol, both as sole extractant and in admixture with water. Particularly preferred extractants are water, ethanol, 2-propanol, 1,2-propylene glycol, 1 Very particular preference is given to water, ethanol, 2-propanol and 1,2-propylene glycol and mixtures thereof, for example a mixture of 1,2-propylene glycol / water in the ratio 4: 1.

The extraction is preferably carried out at a temperature of 25 ° C to 90 ° C.

Particularly preferred cosmetic or dermatological compositions according to the invention are characterized in that the respective plant extract contains at least one polar solvent selected from ethanol, 1-propanol. 2-propanol, 1-butanol, 2-butanol, Contains ethylene glycol, 1, 2-propylene glycol, 1, 3-butylene glycol, glycerol and water, and mixtures thereof.

Depending on the choice of the extraction agent, it may be preferable to stabilize the extract by adding a solubilizer. Suitable solubilizers are, for. B. Ethoxylation products of optionally hydrogenated vegetable and animal oils. Preferred solubilizers are ethoxylated mono-, di- and triglycerides of C8-22 fatty acids with 4 to 50 ethylene oxide units. z. Hydrogenated ethoxylated castor oil, olive oil ethoxylate, almond oil ethoxylate, mink oil ethoxylate, polyoxyethylene glycol caprylic / capric acid glycerides,

Polyoxyethylene glycerol monolaurate and polyoxyethylene glycol coconut fatty acid glycerides. Olive oil ethoxylate (INCI name: PEG-10 Olive Glycerides) is particularly preferred.

The dry matter of the extract is dependent on the molecular weight and the solubility of the dispersed ingredients and is usually 1 to 80 wt .-%, in each case based on the weight of the extract. The dry matter is preferably from 10 to 70% by weight and more preferably from 20 to 60% by weight.

Particularly preferred plant extracts which are suitable for use in the compositions according to the invention are selected from: flowers of Lonicera japonica (Japanese honeysuckle), fruits of Xanthium sibiricum (pointed pimples). Roots of Cyperus rotundus (Nagarmustaka). Corn kernels (Zea mays (Com) Kernel Extract). Oat grains (Ave na Sativa (Oat) Kernel Extract). Apple Seed Extracts (Pyrus Malus (Apple) Fruit Extract), Lotus Seeds (Nelumbo Nucifera Germ Extract), Red Wine. Grape seeds, black elder flowers (Sambucus Nigra Flower Extract), leaves of Mentha piperita, cocoa beans and / or Quassia amara.

Especially preferred are extracts of Quassia amara.

The abovementioned plant extracts can be used both individually and in the form of different mixtures in the compositions according to the invention. Preferably, the amount used of each extract - based on the total weight of the composition - 0.01 to 5.00 wt .-%, more preferably 0.02 to 4.50 wt .-%, particularly preferably 0.03 to 4.00 wt. -%, most preferably 0.04 to 3.50 wt .-% and in particular 0.05 to 3.00 wt .-%.

Quassia amara (Brazilian Quassia tree, Quassia tree, Bitterwood) is a species in the broom family (Simaroubaceae). It is widespread in the Neotropics. The extracts which can be used according to the invention are preferably obtained from the wood.

Extracts from Quassia amara can according to known manufacturing processes in variable composition with solvents such. B. water. Methanol, ethanol, acetone, etc., and mixtures thereof at temperatures from room temperature to 100 ° C with gentle to vigorous mixing within 10 min. To 24 hours. Under atmospheric pressure up to 200 bar. For enrichment of effectiveness-determining components further concentration steps can be carried out such. B. liquid-liquid distribution with z. B. 1 - Butanol / water or ethyl acetate / water, adsorption desorption on ion exchanger, LH20, HP20 and other resins or chromatographic separations over RP18, silica gel, etc. If the further processing to dry extracts is desired, this is carried out according to known methods by removing the solvent at elevated temperature and / or reduced pressure.

In a preferred embodiment, the compositions according to the invention contain as active ingredient d) at least one extract of Quassia amara.

Within this embodiment, it is further preferred if the compositions according to the invention contain the Quassia amara extract in an amount, based on the total weight of the compositions, of from 0.05 to 5.00% by weight, more preferably from 0.10 to 4, 00 wt .-%, particularly preferably from 0.20 to 3.00 wt .-%, very particularly preferably from 0.30 to 2.50 wt .-% and in particular from 0.40 to 2.00 wt .-% contain.

Another preferred active ingredient d) which is particularly suitable for use in the compositions according to the invention is selected from hyaluronic acid and / or an ester of hyaluronic acid and / or a salt of hyaluronic acid, since these active ingredients increase skin moisture significantly to increase the elasticity of the skin Skin can contribute.

Suitable salts of hyaluronic acid are preferably their alkali metal and / or ammonium salts, for example the hyaluronic acid salt commercially available under the INCI name Sodium Hyaluronate from various suppliers (Therapo, CPN).

Preferred esters of hyaluronic acid may be selected from silanol esters, as obtainable, for example, under the INCI name Dimethylsilanol Hyaluronate. A preferred commercial product is offered for example by the company under the name Exsymol DSH CN ^® commercially.

As an alternative to hyaluronic acid in pure form, it can also be part of small beads which can be added to the compositions according to the invention. Suitable beads are available, for example under the trade name Hyaluronic Filling Spheres ^® by the company BASF.

The compositions according to the invention contain hyaluronic acid and / or esters and / or salt (s) of hyaluronic acid in an amount (based on the total weight of the compositions according to the invention) of from 0.01 to 10.00% by weight, preferably from 0.05 to 7 , 50% by weight, particularly preferably from 0.10 to 5.00% by weight, very particularly preferably from 0.20 to 4.50% by weight and in particular from 0.25 to 4.00% by weight ,

In a further preferred embodiment, compositions according to the invention are characterized in that they contain as active ingredient d) hyaluronic acid, esters and / or salts of hyaluronic acid, preferably hyaluronic acid, alkali metal and / or ammonium salts of Hyaluronic acid and / or silanol esters of hyaluronic acid and in particular the compounds known under the INCI names Hyaluronic Acid, Sodium Hyaluronate and / or Dimethylsilanol Hyaluronate.

Within this embodiment, particular preference is given to compositions according to the invention which are 0.01 to 5.00% by weight, preferably 0.02 to 4.50% by weight, more preferably 0.03 to 4.00% by weight, very particularly preferably 0.04 to 3.50% by weight and in particular 0.05 to 3.00% by weight of hyaluronic acid (Hyaluronic Filling ^Spheres® ) and / or dimethylsilanol hyaluronates.

It has been found that the anti-wrinkle depth effect of the compositions according to the invention can be increased to a particular extent if combinations of plant extracts, in particular of Quassia amara extract and hyaluronic acid (derivatives), are added to them as active ingredients d).

According to a further embodiment, very particularly preferred compositions according to the invention are characterized in that they contain as active ingredient d) a mixture of Quassia Amara extract and

at least one of the compounds known under the INCI names Hyaluronic Acid, Sodium Hyaluronate and / or Dimethylsilanol Hyaluronate.

Most preferred within this embodiment are compositions comprising Quassia Amara extract and hyaluronic acid (and / or dimethylsilanol hyaluronates) in a weight ratio of 2: 1 to 1: 5, preferably 1: 5: 1 to 1: 4 and especially 1: 1 to 1: 3 included.

In a further preferred embodiment, compositions according to the invention are characterized in that they contain as active ingredient d) at least one DNA repair enzyme in an amount, based on the total weight of the compositions, of from 0.001 to 3.00% by weight, more preferably from 0.005 to 2 , 50 wt .-%, particularly preferably from 0.01 to 2.00 wt .-%, very particularly preferably from 0.05 to 1, 50 wt .-% and in particular from 0, 10 to 1, 00 Gew. % contain.

Particularly preferred compositions according to the invention are characterized in that the DNA repair enzyme is selected from photolyase and T 4 endonuclease V and mixtures of these enzymes.

A further preferred embodiment of the invention is therefore characterized in that it contains as active ingredient d) at least one DNA repair enzyme from the group photolyase and T 4 endonuclease V as well as mixtures of these enzymes. The DNA repair enzymes can be both encapsulated in liposomes and freely, that is not encapsulated, present. The encapsulation of the liposomes may preferably be carried out with phospholipids, more preferably with lecithin. Particularly preferred according to the invention is the use of at least one liposome-encapsulated DNA repair enzyme.

Liposome-encapsulated photolyase is commercially available for. B. under the product name Photosomes ^® (INCI name: Aqua, lecithin, plankton extract), liposome-encapsulated T4N5 is z. B. under the name Ultrasomes ^® (INCI name: Aqua, lecithin, Micrococcus Lysate) from AGI Dermatics, USA, available.

Since a longer period of storage of both the commercial product and the compositions of the invention between the encapsulated aqueous phase containing the enzyme and the non-encapsulated outer aqueous phase equilibrium, a part of the DNA repair enzymes is present without encapsulation.

In the inventive compositions, the commercial products Photo somes ^® or Ultrasomes ^® are preferably each present in amounts of 0.001-1, 00 wt .-%, more preferably from 0.005 to 0.75 wt .-%, particularly preferably from 0.01 to 0.50 Wt .-%, most preferably from 0.05 to 0.40 wt .-% and in particular from 0.10 to 0.30 wt .-%, based on the total agent.

The skin damaging effect of the ultraviolet part of solar radiation is known.

So it is u. a. It has been proven that even under normal everyday conditions even UV-A radiation is sufficient to rapidly damage the collagen and elastin fibers, which are essential for the structure and firmness of the skin. This leads to chronic light-induced skin changes - the skin "ages" prematurely. The clinical appearance of light aged skin includes, for example, wrinkles and wrinkles.

It is therefore furthermore advantageous if the compositions according to the invention can counteract the formation of wrinkles in addition to the treatment of existing skin folds.

Organic UV filters in the amounts required for a high sun protection factor are often difficult to incorporate into cosmetic carriers so that long-term stable compositions are obtained with pleasant, especially non-sticky properties.

To produce particularly high-performance sunscreen compositions in the form of oil-water emulsions, it is advantageous if at least one organic UV filter is contained both in the oil phase and in the water phase.

It has been found that the combination of active substances according to the invention comprising, inter alia, the emulsifier system a), b), c) is particularly well suited as the basis for a large number of dermatologically well-tolerated UV filters. In a further preferred embodiment, the cosmetic or dermatological compositions according to the invention therefore comprise from 0.01 to 25.00% by weight of at least one UV filter, the quantities being based on the total weight of the compositions. Further preferred amounts of the at least one UV filter in the compositions of the invention from 0.05 to 22.50 wt .-%, particularly preferably from 0, 10 to 20.00 wt%, most preferably from 0.50 to 17.50 wt .-% and in particular from 1, 00 to 15.00 wt .-%.

Preferred water-soluble organic UV filters are preferably selected from

2-phenylbenzimidazole-5-sulfonic acid and / or

Derivatives of benzimidazole sulfonic acid e.g. Phenylene-1,4-bis (2-benzimidazyl) -3,3'-5,5'-tetrasulfonic acid and its salts. Exceptionally preferred is the phenylene-1,4-bis (2-benzimidazyl) -3,3'-5,5'-tetrasulfonic acid bis-sodium salt (INCI name Disodium Phenyl Dibenzimidazole Tetrasulfonate), marketed for example under the trade name Neo Heliopan AP is available from Symrise.

Preferred UV filters dissolved in the oil phase are selected from

2-Cyano-3,3-phenylcinnamic acid 2-ethylhexyl ester (INCI name Octocrylene). Octocrylene is preferred in a total amount of from 0.50 to 15.00 wt%, more preferably from 1.00 to 13.00 wt%, especially from 3.00 to 1100 wt%, and most preferably 5 , 00 to 10.00 wt .-%, contained in the compositions of the invention, wherein the amounts are based on the total weight of the compositions.

4-tert-butyl-4'-methoxydibenzoylmethane (INCI name Butyl

Methoxydibenzoylmethane). Preferred compositions according to the invention comprise 4-tert-butyl-4'-methoxydibenzoylmethane in a total amount of 0.50 to 10.00% by weight, preferably 1.00 to 8.00% by weight, particularly preferably 2.00 to 5 , 00 wt .-% and most preferably 3.00 to 4.00 wt .-%, each based on the total weight of the composition according to the invention,

3,3,5-trimethylcyclohexyl salicylate (INCI name homosalates), e.g. B. as Neo Heliopan HMS Symrise available. Preferred oil-in-water emulsions according to the invention comprise 3,3,5-trimethylcyclohexyl salicylate in a total amount of from 0.50 to 10.00% by weight, preferably from 2.00 to 9.00% by weight, more preferably 3, 00 to 8.00 wt .-%, most preferably 3.50 to 7.00 wt .-%, each based on the total weight of the composition according to the invention, and

from mixtures of the aforementioned UV filters. In a further preferred embodiment, the compositions according to the invention comprise as UV filter at least one derivative of benzimidazole sulphonic acid and at least one further of the UV filters known under the INCI names Octocrylene and Homosalate.

For the purposes of the present invention, O / W emulsions may, for example, be in the form of creams, lotions and / or cosmetic milks and, in addition to the aforementioned active substances, furthermore contain fats, oils, waxes and / or other fatty substances as well as water and optionally further emulsifiers.

The content of the water phase in the O / W emulsions according to the invention is preferably 10 to 90% by weight, preferably 15 to 85% by weight, more preferably 20 to 80% by weight, even more preferably 25 to 75% by weight. % and in particular 30 to 70 wt .-%, wherein the amounts are based on the total weight of the O / W emulsions.

The term "water phase" in the context of the invention means both water and a water-alcohol mixture.

The alcohol content in the emulsions according to the invention may preferably be from 1 to 40% by weight, more preferably from 2 to 30 and in particular from 3 to 20% by weight. Suitable alcohols are preferably glycol, 1,2-propylene glycol, 1,3-propylene glycol, 2-methyl-1,3-propanediol, glycerol, 1,2-butylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, pentylene glycols , 1, 2-hexanediol, 1, 6-hexanediol, 1, 2,6-hexanetriol, 1, 2-octanediol, 1, 8-octanediol, dipropylene glycol, tripropylene glycol, diglycerol, triglycerol, erythritol, sorbitol, polyethylene glycol and mixtures of the aforementioned Substances into consideration.

Preference is given to water-soluble alcohols.

Preferred water-soluble polyethylene glycols may be selected from PEG-3, PEG-4, PEG-6, PEG-7, PEG-8, PEG-9, PEG-10, PEG-12, PEG-14, PEG-16, PEG-18 and PEG-20 and mixtures thereof, with PEG-3 to PEG-8 being particularly preferred. Sugar and certain sugar derivatives such as fructose, glucose, maltose, maltitol, mannitol, inositol, sucrose, trehalose and xylose may also be preferred according to the invention.

Particularly preferred compositions of the invention contain as alcohol 1, 2-propylene glycol, glycerol, 1, 3-butylene glycol, 1, 6-hexanediol, diglycerol, triglycerol, dipropylene glycol and / or tripropylene glycol.

The oil phase is present in O / W emulsions according to the invention, preferably in a weight range of 0.50-50.00% by weight, based on the total weight of the O / W emulsion. more preferably from 1.00 to 40.00 wt%, more preferably from 1.50 to 30.00 wt%, and most preferably from 2.00 to 25.00 wt%. The emulsifier (s) is (are) counted neither the oil phase nor the water phase. In a preferred embodiment, the oil phase consists of at least 90 wt .-% of an oil component at 20 ° C liquid.

Preferred oil components which can be used in emulsions which are preferred according to the invention are selected, for example, from:

volatile silicone oils, which may be cyclic, such as. For example, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane and dodecamethylcyclohexasiloxane and mixtures thereof, as described for. In the commercial products DC 244. 245, 344 and 345 of Dow Corning, or linear, e.g. As hexamethyldisiloxane (L 2), octamethyltrisiloxane (L 3), decamethyltetrasiloxane (L 4), any two and three mixtures of L 2, L 3 and / or L 4, as described, for. B. in the commercial products DC 2-1184, Dow Corning ^® 200 (0.65 cSt), and Dow Corning ^® 200 (1, 5 cSt) contained by Dow Corning.

nonvolatile higher molecular weight linear dimethylpolysiloxanes, commercially available e.g. Dow ^Coming® 190, Dow ^Corning® 200 fluid with viscosities in the range of 5 - 100 cSt, preferably 5 - 50 cSt or even 5 - 10 cSt, and Baysilon ^® 350 M,

the esters of linear or branched saturated or unsaturated fatty alcohols having 2 to 30 carbon atoms with linear or branched saturated or unsaturated fatty acids having 2 to 30 carbon atoms which may be hydroxylated. These include 2-ethylhexyl palmitate (z. B. Cegesoft ^® C 24), hexyldecyl stearate (EutanoP G 16), hexyldecyl laurate, isodecyl neopentanoate, isononyl isononanoate, 2-ethylhexyl stearate, isopropyl myristate, isopropyl palmitate, isopropyl stearate, isopropyl isostearate, isopropyl oleate. Isooctyl stearate, isononyl stearate, isocetyl stearate, isononyl isononanoate, isotridecyl isononanoate. Cetearylisononanot, 2-ethylhexyl laurate, 2-ethylhexyl isostearate, 2-ethylhexyl cocoate, 2-octyl dodecyl palmitate, butyloctanoic acid 2-butyloctanoate, diisotridecyl acetate, n-butyl stearate, n-hexyl laurate, n-decyl oleate, oleyl oleate, oleyl erucate, erucyl oleate, erucyl erucate, ethylene glycol dioleate and dipalmitate .

the benzoic acid esters of linear or branched Cs-22-alkanols. z. , The commercial products Finsolv ^® TN (Ci2-Cis-alkyl benzoate), Finsolv ^® SB (isostearyl benzoate), and Finsolv EB ^® (ethylhexyl)

the C8-C22-fatty alcohol esters of monovalent or polyvalent C2-C ?? -hydroxycarboxylic acids, in particular the esters of glycolic acid, lactic acid, malic acid, tartaric acid, citric acid and salicylic acid. Such esters based on linear Cuns alkanols, eg. B. Ci2-Cib-alkyl lactate, and of branched in the 2-position C u; 13-alkanols. z. B. Di-C; 2-C 13-AI ky I ma lat, under the trademark Cosmacol ^® by the company Nordmann, Rassmann GmbH & Co, Hamburg, relate, in particular the commercial products Cosmacol ^® EMI, Cosmacol ^® ESI and Cosmacol ^® ETI.

the addition products of ethylene oxide and / or propylene oxide to mono- or polyhydric Cs 20 alkanols such as butanol. Butanediol. Myristyl alcohol and stearyl alcohol, e.g. For example, PPG-14-butyl ether (Ucon ^® fluid, PPG-9-butyl ether (Breox B25 ^®), PPG-10 butanediol (Macol ^® 57), PPG-3 yristylether (Witconol APM ^®) and PPG-15 stearyl ether (Arlamol ^® E),

liquid paraffin oils, isoparaffin oils, e.g. As the commercial products of the Permethyl * series, in particular isododecane, isohexadecane and isoeicosane.

synthetic hydrocarbons such as polyisobutene or polydecene and alicyclic hydrocarbons, e.g. As the commercial product 1.3-di- (2-ethyl-hexyl) -cyclohexane (Cetiol ^® S), the branched saturated or unsaturated fatty alcohols having 6 to 30 carbon atoms. These alcohols are also often referred to as Guerbet alcohols, since they are available after the Guerbet reaction. Particularly preferred alcohol oils are for example hexyldecanol (eutanol ^® G). Octyldodecanol and 2-ethylhexyl alcohol,

Blends of Guerbet alcohols and Guerbet alcohol esters, e.g. The commercial product Cetior * PGL (hexyldecanol and hexyldecyl laurate),

the symmetrical, asymmetrical or cyclic esters of carbonic acid with fatty alcohols, for example glycerol carbonate, dicaprylyl carbonate (Cetiol ^® CC),

Triglycerides of linear or branched, saturated or unsaturated, optionally hydroxylated C 8-30 fatty acids. Particularly suitable may be the use of natural oils, for example soybean oil, cottonseed oil, sunflower oil, palm oil, palm kernel oil. Linseed oil, almond oil, castor oil, corn oil. Olive oil. Rapeseed oil, sesame oil, thistle oil, wheat germ oil, peach kernel oil, and the liquid portions of coconut oil, and the like. But are also synthetic triglyceride oils, in particular Capric / Caprylic triglycerides, z. B. the commercial products Myritof ⁶ 318, yritoi ^® 331 (Cognis) or Miglyol ^® 812 (Hüls) and glyceryl triisostearin and the commercial products Estol ^® GTEH 3609 (Uniqema) or Myritol ^® GTEH (Cognis),

Dicarboxylic acid esters of linear or branched C 2 -C 10 -alkanols, in particular diisopropyl adipate, di-n-butyl adipate, di (2-ethylhexyl) adipate, dioctyl adipate, diethyl / dinutyl / dioctyl sebacate, diisopropyl sebacate, dioctyl malate, dioctyl maleate, dicaprylyl maleate, diisooctyl succinate, Di-2-ethylhexyl succinate and di (2-hexyldecyl) succinate,

Di-n-alkyl ethers having a total of 12 to 36, in particular 12 to 24 carbon atoms, for. As di-n-octyl ether (Cetiol ^® OE), di-n-hexyl-n-octyl ether and n-octyl-n-decyl ether.

Particularly preferred oils are silicone oils and esters of linear or branched saturated or unsaturated fatty alcohols having 2 to 30 carbon atoms with linear or branched saturated or unsaturated fatty acids having 2 to 30 carbon atoms, especially volatile and nonvolatile silicone oils from the Dow Corning 200 Fluid series and / or Dow Corning 9041 which Esteröle 2-ethylhexyl palmitate, hexyldecyl laurate, 2-ethylhexyl stearate, isopropyl myristate, isopropyl palmitate and 2-ethylhexyl laurate and / or the benzoic acid esters of linear or branched C 22 alkanols, in particular the commercial product Finsolv ^®. It may also be preferred for some embodiments of the compositions of the invention to use mixtures of the aforementioned oils. There are especially mixtures of two types of oil components. z. As a silicone oil and an ester oil. prefers.

In addition to the cosmetic ingredients and active ingredients mentioned above, the compositions according to the invention may also contain further optional constituents which give them advantageous properties. Other possible ingredients include in particular:

natural or synthetic stabilizers (hydrogel former). for example, anionic copolymers such as the commercial products Sepigel ^® 305 from SEPPIC, Simulgel ^® 600, Simulgel ^® NS, Simulgel ^® EG, Simulgel ^® EPG and Sepiplus ^® 400, Aristoflex ^® AVC from Clariant and the different under the INCI names Carbopol commercially available from products available providers, such as Carbopol Ultrez ^® 30 by the company Lubrizol, the Pemulen ^® and Carbopol ^® grades 954, 980, 1342 and ETD 2020 (ex Noveon and BF Goodrich), nonionic hydrogel as the commercial products Mowiol ^® and Luviskol ^® (BASF) and / or natural hydrogel former preferably hydroxyalkylcelluloses such as hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, methylcellulose,

Hydroxymethylcellulose, carboxymethylcellulose, and starch and starch degradation products such as amylose and amylopectin, chemically and / or thermally modified starch, eg hydroxypropyl starch phosphate, dihydroxypropyldistarch phosphate, in particular the anionic starch derivatives aluminum starch octenylsuccinate (eg the commercial products Dry ^Flo® ), sodium starch octenylsuccinate, calcium starch octenylsuccinate, furthermore chitosan and its Derivatives, furthermore, polysaccharides which form gums or gums, such as guar gum, xanthan gum, alginates, especially sodium alginate, gum arabic, karaya gum, carrageenans, locust bean gum, linseed gums, shellac and agar-agar,

Vitamins, provitamins and / or vitamin precursors, preferably those which are assigned to the groups A, B, F and H, and in particular vitamin E acetate, vitamin A palmitate, niacinamide, panthenol, linoleic acid, linolenic acid and / or biotin. The vitamins, provitamins and / or vitamin precursors can be present in the compositions according to the invention (based on their total weight) in amounts of from 0.01 to 5.00% by weight in each case.

Preservatives such as benzoic acid derivatives, phenoxyethanol, octoxyglycerol, which may be contained in the compositions of the invention (based on the total weight) in each case in amounts of from 0.01 to 2.00 wt .-%.

Physiologically acceptable acids and / or bases for adjusting the pH,

Perfumes.

A second object of the invention is the non-therapeutic, cosmetic use of the composition according to the invention for the reduction and / or prevention of signs of aging of the skin, in particular skin folds and / or lines, signs of intrinsic and extrinsic skin aging, tired and / or saggy skin and / or skin damaged by UV light.

A third object of the invention is a non-therapeutic, cosmetic method for reducing and / or preventing signs of aging of the skin, in particular for reducing and / or preventing skin folds and / or lines, signs of intrinsic and extrinsic aging of the skin, tired and or flaccid skin and / or skin damaged by exposure to UV light, which is characterized in that a composition according to the invention is preferably applied to the - preferably previously cleaned - at least every 24 hours, more preferably at least every 18 hours and in particular at least every 12 hours. Skin is applied.

With regard to preferred embodiments of the use according to the invention and / or the method according to the invention, what has been said about the compositions according to the invention applies mutatis mutandis.

The following examples illustrate the invention without, however, limiting it to:

Examples:

The following cosmetic or dermatological skin lightening compositions were prepared, all numerical values in the following examples, unless otherwise stated, corresponding to the amount of the respective active ingredient in percent by weight, based on the total weight of the composition:

^* R: saturated alkyl radical having 12-24 C atoms; G: sugar residue with 5 or 6 C atoms; x: 1-10

Formula 11 Formula 12 Formula 13 Formula 14 Formula 15

Cetyl phosphate (salt) 0.01-3.00 0.025-2.75 0.05-2.50 0.075-2.25 0.10-2.00

Hydrolyzed 0.01-3.00 0.02-2.60 0.03-2.30 0.04-2.00 0.05-1.70 palm oil glyceride

Cetearyl Glucoside 0.05-5.00 0.10-4.50 0.25-4.00 0.50 - 3.50 0.75-3.00

Anti-Age active ingredient 0.001 0.001 0.002 0.003 0.004

5.00 4.50 4.00 3.50 3.00

Water and other ad 100 ad 100 ad 100 ad 100 ad 100 ingredients Formula 16 Formula 17 Formula 18 Formula 19 Formula 20

Emulsiphos®1 ⁶⁷⁷⁶⁶⁰ 0.05-5.00 0.075-4.75 0.10-4.50 0.15-4.25 0.20-4.00

Tego ^Care®2 CG 90 0.05-5.00 0.10-4.50 0.25-4.00 0.50-3.50 0.75-3.00

Anti-Age active ingredient 0.001 0.001 0.002 0.003 0.004

5.00 4.50 4.00 3.50 3.00

Water and other ad 100 ad 100 ad 100 ad 100 ad 100 ingredients

Formula 36 Formula 37 Formula 38 Formula 39 Formula 40

Emulsiphos®1 ⁶⁷⁷⁶⁶⁰ 0.05-5.00 0.075-4.75 0.10-4.50 0.15-4.25 0.20-4.00 Tego ^Care®2 CG 90 0.05-5.00 0.10-4.50 0.25-4.00 0.50-3.50 0.75-3.00

Hyaluronic acid and / or 0.01 - 10.0 0.05-7.50 0.10-5.00 0.20-4.50 0.25-4.00 Ester and / or salt (s)

hyaluronic acid

Water and other ad 100 ad 100 ad 100 ad 100 ad 100 ingredients

Formula 51 Formula 52 Formula 53 Formula 54 Formula 55

Cetyl phosphate (salt) 0.01-3.00 0.025 0.05-2.50 0.075 0.10-2.00

2.75 2.25

Hydrolyzed palm oil glyceride 0.01 -3.00 0.02-2.60 0.03-2.30 0.04-2.00 0.05-1.70

Cetearyl Glucosides 0.05-5.00 0.10-4.50 0.25-4.00 0.50 - 3.50 0.75

3.00 Photolyase and / or T 4 0.001 0.005 0.01 0.05 0.10 Endonuclease V 1.00 0.75 0.50 0.40 0.30

Water and other ad 100 ad 100 ad 100 ad 100 ad 100 ingredients

Formula 71 Formula 72 Formula 73 Formula 74 Formula 75

Cetyl phosphate (salt) 0.01-3.00 0.025-2.75 0.05-2.50 0.075-2.25 0.10-2.00

Hydrolyzed 0.01-3.00 0.02-2.60 0.03-2.30 0.04-2.00 0.05-1.70 palm oil glyceride Cetearyl Glucoside 0.05-5.00 0.10-4.50 0.25-4.00 0.50 - 3.50 0.75-3.00

Quassia Amara Extract 0.05-5.00 0.10-4.00 0.20-3.00 0.30-2.50 0.40-2.00

Hyaluronic Acid, Sodium 0.01 - 10.0 0.05-7.50 0.10-5.00 0.20-4.50 0.25-4.00 Hyaluronates and / or

dimethylsilanol

Hyaluronate

UV filter 0.01 -25.0 0.05-22.5 0.10-20.0 0.50-17.5 1.00-15.0

Water and other ad 100 ad 100 ad 100 ad 100 ad 100 ingredients

Formula 80

Emulsiphos ^®1 677 660 0.01 to 1.00

Tego ^Care®2 CG 90 0.01 to 2.00

lllumiscin ^®9 0.50 to 3.00

Radianskin ^®10 PW LS 9918 0.10 to 2.00

DSHCN ^®11 1.00 to 3.00

Quassia amara extract 0.50 to 2.00

Cetearyl alcohol 0.50 to 2.00

^Lanette®3 22 1.00 to 5.00

Caprylic / Capric Triglycerides 3.00 to 7.00

Cetiol CC® ² 2.00 to 5.00 Cetiol SB ^{45®13 1.00} to 3.00

Vitamin E-acetate 0, 10 to 1, 00

Exfolactive ^EL®14 1, 00 to 3,00

Hyaluronic Filling Sheres®6 0.50 to ^1.50

Carbopol ETD® ⁵ 2020 0, 10 to 1, 00

Dow Corning 9041 ^®16 0, 10 to 2:00

Homosalats 3.00 to 5.00

Octocrylene 6.00 to 10.0

Neo Heliopan ^®17 AP 0.10 to 2.00

Water and other ingredients ad 100

INCI name Supplier /

Manufacturer

Emulsiphos ® ¹ 677660 Potassium Cetyl Phosphate, Hydrogenated Symrise

Palm Glycerides

Tego ^Care®2 CG 90 Cetearyl Glucoside Evonik

^Lanette®3 22 Behenyl Alcohol BASF

^Cutina®4 MD Glyceryl Stearate BASF

Cetiol SB ^45®5 Shea Butter BASF

Hyaluronic Filling Sheres ^®6 Ethylhexyl Palmitate, Silica Dimethyl Silylate, BASF

Butylene Glycol, Hyaluronic Acid

Photosomes ^®7 V Plankton Extract, Lecithin Barnet

Ultrasomes ® ⁸ V Aqua, Lecithin, Micrococcus Lysate Barnet lllumiscin ^®9 Glycerin, Aqua, Olea Europaea Leaf Extract, Rahn AG

Ascorbyl Glucoside, Zinc PCA, Ascorbic Acid

Radianskin ^®10 PW LS 9918 hydroxyphenoxy Propionic Acid BASF

DSH CN ^® dimethylsilanol Hyaluronate Exsymol

Cetiol CC® ² dicaprylyl carbonates BASF

Cetiol SB ^45®13 Shea Butter BASF

Exfolactive ^EL®14 Hydrolyzed Opuntia ficus indica Flower Extract Silab

Carbopol ^ETD®15 2020 Acrylates / Cio-3o Alkyl Acrylates Crosspolymer Lubrizole

Dow Corning 9041®16 ^dimethicone , Dimethicone Crosspolymer Dow Corning

Neo Heliopan ^®17 AP Disodium phenyl Dibenzimidazole Symrise

Tetrasulfonate

Claims

claims:

1. Cosmetic or dermatological composition in the form of an oil-in-water emulsion containing a combination of the following active ingredients a) - d)

b) 0.01 to 3.00 wt .-% of at least one - optionally hydrolyzed - Ci4-2o mono- or diacylglyceride,

c) 0.05 to 5.00 wt .-% of at least one alkyl (oligo) glycoside of the general formula RO- [G] x, in the R for a saturated alkyl radical having 12 to 24 carbon atoms, G for a sugar residue with 5 or 6 C atoms and x represents numbers from 1 to 10, and d) at least one active ingredient for reducing and / or preventing signs of aging of the skin,

2. Composition according to claim 1, characterized in that it - based on their total weight - a) 0.025 to 2.75 wt .-%, preferably 0.05 to 2.50 wt .-%, particularly preferably 0.075 to 2.25 Wt .-% and in particular 0, 10 to 2.00 wt .-% of at least one salt of a Ci2-2o-Alkylphoshats, preferably a salt of cetyl phosphate,

b) 0.02 to 2.60 wt.%, preferably 0.03 to 2.30 wt.%, particularly preferably 0.04 to 2.00 wt.% and in particular 0.05 to 1.70 wt. % of at least one - optionally hydrolyzed - C.sub.4-2o-mono- or diacylglyceride, preferably of a hydrolyzed C.sub.5-ie-mono- or diacylglyceride and in particular hydrolyzed palm oil glyceride,

c) 0.10 to 4.50 wt .-%, preferably 0.25 to 4.00 wt .-%. particularly preferably 0.50 to 3.50 wt .-% and in particular 0.75 to 3.00 wt .-% of at least one alkyl (oligo) glycoside of the general formula RO- [G] x, in the R for a saturated alkyl radical with 12th to 24 carbon atoms, G is a sugar moiety having 5 or 6 carbon atoms and x is from 1 to 10, preferably an alkyl (oligo) glycoside known by the INCI name cetearyl glucoside, and

3. A composition according to any one of claims 1 or 2, characterized in that it contains at least one active ingredient d) selected from plant extracts, hyaluronic acid, esters and / or salts of hyaluronic acid, DNA repair enzymes and mixtures of these active ingredients.

4. The composition of claim 2, containing as active ingredient d) at least one extract of Quassia Amara.

5. Composition according to claim 2, containing as active ingredient d) hyaluronic acid, esters and / or salts of hyaluronic acid, preferably hyaluronic acid, alkali metal and / or ammonium salts of hyaluronic acid and / or silanol esters of hyaluronic acid and in particular those under the INCI names hyaluronic acid, Sodium hyaluronates and / or dimethylsilanol hyaluronates known compounds.

6. Composition according to one of claims 2 to 5, characterized in that it comprises as active ingredient d) a mixture of

Quassia Amara extract and

7. The composition of claim 2, containing as active ingredient d) at least one DNA repair enzyme from the group photolyase and T 4 endonuclease V and mixtures of these enzymes.

8. Composition according to one of claims 1 to 7, characterized in that it contains - based on their total weight - 0.01 to 25.00 wt .-% of at least one UV filter.

Non-therapeutic, cosmetic use of a composition according to any one of claims 1 to 8 for reducing and / or preventing signs of aging of the skin, in particular skin folds and / or lines, signs of intrinsic and extrinsic skin aging, tired and / or sagging skin and / or skin damaged by UV light.

10. A non-therapeutic, cosmetic method for reducing and / or preventing signs of aging, in particular for reducing and / or preventing skin folds and / or lines, signs of intrinsic and extrinsic skin aging, tired and / or sagging skin and / or skin damaged by exposure to UV light, which is characterized in that a composition according to one of claims 1 to 8, preferably at least every 24 hours, more preferably at least every 18 hours and in particular at least every 12 hours, is applied to the - preferably previously cleaned - skin.