WO2017029298A1 - Composition antivirale topique - Google Patents

Composition antivirale topique Download PDF

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Publication number
WO2017029298A1
WO2017029298A1 PCT/EP2016/069450 EP2016069450W WO2017029298A1 WO 2017029298 A1 WO2017029298 A1 WO 2017029298A1 EP 2016069450 W EP2016069450 W EP 2016069450W WO 2017029298 A1 WO2017029298 A1 WO 2017029298A1
Authority
WO
WIPO (PCT)
Prior art keywords
oil
weight
total formulation
pharmaceutical composition
topical pharmaceutical
Prior art date
Application number
PCT/EP2016/069450
Other languages
English (en)
Inventor
Ali TÜRKYILMAZ
Nur PEHLIVAN AKALIN
Sevda TUNA
Original Assignee
Sanovel Ilac Sanayi Ve Ticaret A.S.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanovel Ilac Sanayi Ve Ticaret A.S. filed Critical Sanovel Ilac Sanayi Ve Ticaret A.S.
Priority to EP16759693.1A priority Critical patent/EP3337512A1/fr
Publication of WO2017029298A1 publication Critical patent/WO2017029298A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Abstract

La présente invention concerne une composition topique comprenant un principe actif antiviral ou des analogues ou dérivés de ce dernier, qui est enrichi en huiles contre l'herpès en combinaison avec un principe actif acide ou des analogues ou dérivés de ce dernier qui est enrichi en huiles.
PCT/EP2016/069450 2015-08-17 2016-08-16 Composition antivirale topique WO2017029298A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP16759693.1A EP3337512A1 (fr) 2015-08-17 2016-08-16 Composition antivirale topique

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TR201510146 2015-08-17
TR2015/10146 2015-08-17

Publications (1)

Publication Number Publication Date
WO2017029298A1 true WO2017029298A1 (fr) 2017-02-23

Family

ID=56852229

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2016/069450 WO2017029298A1 (fr) 2015-08-17 2016-08-16 Composition antivirale topique

Country Status (2)

Country Link
EP (1) EP3337512A1 (fr)
WO (1) WO2017029298A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112514926A (zh) * 2020-12-14 2021-03-19 杭州象外环保科技有限公司 一种灭活冠状病毒的天然植萃精油消毒剂及应用
CN112616861A (zh) * 2020-12-14 2021-04-09 杭州象外环保科技有限公司 一种天然植萃精油新型冠状病毒消毒剂及其应用
WO2023062348A1 (fr) 2021-10-13 2023-04-20 Reckitt Benckiser Health Limited Compositions antivirales et leurs procédés de production et d'utilisation

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4199574A (en) 1974-09-02 1980-04-22 Burroughs Wellcome Co. Methods and compositions for treating viral infections and guanine acyclic nucleosides
EP0044543B1 (fr) 1980-07-18 1984-06-06 The Wellcome Foundation Limited Formulations topiques à base de 9(2-hydroxyéthoxyméthyl) guanine
WO1987005604A1 (fr) 1984-09-20 1987-09-24 Beecham Group P.L.C. Derives de 2-aminopurine et procede de preparation desdits derives
WO1991011187A1 (fr) 1990-01-26 1991-08-08 Beecham Group Plc Preparation pharmaceutique
WO1998017264A1 (fr) * 1996-10-24 1998-04-30 Nextech Enterprises International Composition et procede de traitement topique des infections a herpesvirus actives
US5869529A (en) * 1994-07-20 1999-02-09 Agis Industries (1983) Ltd. Topical preparation for the prevention and treatment of lesions and sores associated with a herpes virus
WO2009115510A1 (fr) * 2008-03-17 2009-09-24 Medivir Ab Formulation antivirale
WO2013046161A1 (fr) * 2011-09-28 2013-04-04 Fidia Farmaceutici S.P.A. Compositions pharmaceutiques topiques comprenant de l'acyclovir
WO2014131096A1 (fr) * 2013-02-27 2014-09-04 Advance Pharma Tecnologia E Inovação Ltda - Me Formulation obtenue par association de l'antiviral aciclovir avec la vitamine b6 et un anti-histaminique pour le traitement de l'herpès et moyen d'application

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4199574A (en) 1974-09-02 1980-04-22 Burroughs Wellcome Co. Methods and compositions for treating viral infections and guanine acyclic nucleosides
EP0044543B1 (fr) 1980-07-18 1984-06-06 The Wellcome Foundation Limited Formulations topiques à base de 9(2-hydroxyéthoxyméthyl) guanine
WO1987005604A1 (fr) 1984-09-20 1987-09-24 Beecham Group P.L.C. Derives de 2-aminopurine et procede de preparation desdits derives
WO1991011187A1 (fr) 1990-01-26 1991-08-08 Beecham Group Plc Preparation pharmaceutique
US5869529A (en) * 1994-07-20 1999-02-09 Agis Industries (1983) Ltd. Topical preparation for the prevention and treatment of lesions and sores associated with a herpes virus
WO1998017264A1 (fr) * 1996-10-24 1998-04-30 Nextech Enterprises International Composition et procede de traitement topique des infections a herpesvirus actives
WO2009115510A1 (fr) * 2008-03-17 2009-09-24 Medivir Ab Formulation antivirale
WO2013046161A1 (fr) * 2011-09-28 2013-04-04 Fidia Farmaceutici S.P.A. Compositions pharmaceutiques topiques comprenant de l'acyclovir
WO2014131096A1 (fr) * 2013-02-27 2014-09-04 Advance Pharma Tecnologia E Inovação Ltda - Me Formulation obtenue par association de l'antiviral aciclovir avec la vitamine b6 et un anti-histaminique pour le traitement de l'herpès et moyen d'application

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ADELAIDE: "The Australian Medicines Handbook Unit Trust"
ROSSI, S,: "Australian Medicines Handbook", 2013

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112514926A (zh) * 2020-12-14 2021-03-19 杭州象外环保科技有限公司 一种灭活冠状病毒的天然植萃精油消毒剂及应用
CN112616861A (zh) * 2020-12-14 2021-04-09 杭州象外环保科技有限公司 一种天然植萃精油新型冠状病毒消毒剂及其应用
CN112616861B (zh) * 2020-12-14 2021-10-01 杭州象外环保科技有限公司 一种天然植萃精油新型冠状病毒消毒剂及其应用
CN112514926B (zh) * 2020-12-14 2021-10-01 杭州象外环保科技有限公司 一种灭活冠状病毒的天然植萃精油消毒剂及应用
WO2023062348A1 (fr) 2021-10-13 2023-04-20 Reckitt Benckiser Health Limited Compositions antivirales et leurs procédés de production et d'utilisation

Also Published As

Publication number Publication date
EP3337512A1 (fr) 2018-06-27

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