WO2017006075A1 - Appareil pour inhalateur à poudre sèche - Google Patents

Appareil pour inhalateur à poudre sèche Download PDF

Info

Publication number
WO2017006075A1
WO2017006075A1 PCT/GB2016/000130 GB2016000130W WO2017006075A1 WO 2017006075 A1 WO2017006075 A1 WO 2017006075A1 GB 2016000130 W GB2016000130 W GB 2016000130W WO 2017006075 A1 WO2017006075 A1 WO 2017006075A1
Authority
WO
WIPO (PCT)
Prior art keywords
fresh air
compressed air
air inlet
occluder
dry powder
Prior art date
Application number
PCT/GB2016/000130
Other languages
English (en)
Inventor
Jianhe Li
Original Assignee
Jianhe Li
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jianhe Li filed Critical Jianhe Li
Publication of WO2017006075A1 publication Critical patent/WO2017006075A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/20—Valves specially adapted to medical respiratory devices
    • A61M16/201—Controlled valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0086—Inhalation chambers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A61M15/0093—Inhalators mechanically breath-triggered without arming or cocking, e.g. acting directly on the delivery valve
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A61M15/0095—Preventing manual activation in absence of inhalation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A61M15/0096—Hindering inhalation before activation of the dispenser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/07—General characteristics of the apparatus having air pumping means
    • A61M2205/071—General characteristics of the apparatus having air pumping means hand operated
    • A61M2205/073—Syringe, piston type

Definitions

  • a drug feeder in fluid communication with the trigger valve, wherein on actuation of the trigger valve the drug feeder may be configured to receive a pre-determined quantity of compressed air for aerosolizing a dry powder medicament.
  • a mouthpiece with a distal end and a proximal end, the mouthpiece may be configured to: receive, at the proximal end at a first velocity, a predetermined quantity of aerosolized dry powder medicament from the drug feeder; and provide at least a portion of the predetermined quantity of aerosolized dry powder medicament to the distal end at a second velocity that is lower than the first velocity.
  • the fresh air inlet may be coupled to the mouthpiece and the pre-determined time may be selected such that fresh air from the fresh air inlet may be provided to the mouthpiece after the portion of the predetermined quantity of aerosolized dry powder medicament may be provided to the distal end of the mouthpiece.
  • FIG. 2 shows a simplified version of the active DPI described above in relation to figure 1.
  • the third valve 23 is omitted whereas the sensor 6 acts as a sensor that detects the changes in the volume and/or the pressure of the gas reservoir 5, a trigger that closes a second valve 9 upon charging of the gas reservoir 5 but opens the second valve 9 upon release of the compressed gas in the gas reservoir 5, and performs part of the function of timer 8 in combination with the first valve 4, the trigger 3, the gas reservoir 5 and the second valve 9.
  • a user first manually closes the first valve 4, and then charges the gas reservoir 5 using the pump 11.
  • the sensor 6 detects the increase in pressure and closes the second valve 9. After feeding a unit dose of drug powder using the drug feeder 2, the user inhales from the mouthpiece 1.
  • the trigger assembly may be configured to move from a closed configuration to an open configuration in response to suction provided by the control chamber.
  • the closed configuration the trigger assembly may be configured to occlude the compressed air lumen.
  • the occlusion of the compressed air lumen in the closed configuration may be complete and provide for a gas tight seal of the compressed air lumen.
  • the closed configuration may provide incomplete occlusion of the compressed air lumen; a small amount of leakage of compressed air through the suction actuated valve in its closed configuration may be acceptable.
  • the trigger assembly may be configured to open the compressed air lumen.
  • the compressed air lumen may be completely open in the open configuration while in other examples the compressed air lumen may only be partially open when in the open configuration, such that at least a pre-determined volume of compressed air may be supplied though the compressed air lumen.
  • the trigger assembly may comprise a displaceable membrane contained within the control chamber and displaceable within the control chamber.
  • a rim portion of the displaceable membrane may optionally be coupled to the control chamber such that the coupled rim portion is not displaceable.
  • only a portion of the displaceable membrane may be moveable within the control chamber.
  • the displaceable membrane may be configured to seal the control chamber such that suction provided to the control chamber displaces at least a portion of the displaceable membrane.
  • the displaceable membrane may be configured to seal the control chamber by providing for a gas-tight seal of at least a portion of the control chamber.
  • the trigger assembly in the closed configuration may be configured to compress the elastic tube to occlude the compressed air lumen. This compression may be partial or total, to provide for a partial seal or a gas-tight seal.
  • the trigger assembly in the open configuration the trigger assembly may be configured to decompress the elastic tube to open the compressed air lumen. The decompression of the elastic tube may be partial or total. In some examples the decompression may be provided by the elastic properties of the elastic tube, which may be biased to form an open configuration when a force applied by the trigger assembly is reduced or removed.
  • control chamber may comprise a distal end and a proximal end.
  • the distal end of the control chamber may be coupled to the mouthpiece of an inhaler.
  • Figure 7 shows a side view and a cross-section view of an example embodiment of the fresh air valve of figure 6 in an open configuration, which may be consider an at rest state of the fresh air valve.
  • the check valve 520 is inserted into the valve holder through the centre hole 532.
  • the height of the circular hole 532 is slightly shorter than the distance between the bulge 521 and the flip part 523 so that the elastic force keeps the check valve steady and the flip part 523 in close contact with the smooth surface 533 of the valve holder 530.
  • the compressed air inlet is then inserted into the void 531 of the valve holder 530.
  • the valve holder is then inserted into a circular hole 513 of the base 510.
  • an apparatus for a dry powder inhaler may comprise: a compressed air chamber; an occluder for occluding a fresh air inlet of a dry powder inhaler; an elastic membrane in fluid communication with the compressed air chamber and coupled to the occluder.
  • the elastic membrane may form a wall of the compressed air chamber, configured to contain compressed air within the chamber.
  • the elastic membrane may be considered an example of a sensor because the membrane is sensitive to the pressure within the compressed air chamber and will change its shape in response to changes in the pressure within the compressed air chamber relative to the pressure outside of the compressed air chamber.
  • the occluder may comprise a portion of the elastic membrane.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)

Abstract

L'invention concerne un appareil, pour un inhalateur à poudre sèche, qui comporte : une chambre à air comprimé ; un dispositif d'occlusion pour l'occlusion d'une entrée d'air frais d'un inhalateur à poudre sèche ; une membrane élastique en communication fluidique avec la chambre à air comprimé et couplée au dispositif d'occlusion, la membrane élastique étant configurée : pour déplacer le dispositif d'occlusion vers une position fermée, en une mise en prise étanche avec l'entrée d'air frais, en réponse à une pression d'air dans la chambre à air comprimé pour l'occlusion de l'entrée d'air frais ; pour déplacer le dispositif d'occlusion vers une position ouverte, libérée de l'entrée d'air frais, en réponse à une réduction de la pression d'air pour ouvrir l'entrée d'air frais.
PCT/GB2016/000130 2015-07-08 2016-06-28 Appareil pour inhalateur à poudre sèche WO2017006075A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1511942.3A GB2540170A (en) 2015-07-08 2015-07-08 Dry powder inhaler apparatus
GB1511942.3 2015-07-08

Publications (1)

Publication Number Publication Date
WO2017006075A1 true WO2017006075A1 (fr) 2017-01-12

Family

ID=54013643

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2016/000130 WO2017006075A1 (fr) 2015-07-08 2016-06-28 Appareil pour inhalateur à poudre sèche

Country Status (2)

Country Link
GB (1) GB2540170A (fr)
WO (1) WO2017006075A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3537448A (en) * 1966-03-04 1970-11-03 Liston Fletcher Inc Therapeutic intermittent positive pressure respirator
WO1997006843A1 (fr) * 1995-08-16 1997-02-27 David Weintraub Dispositif de ventilation portatif commande par ordinateur
WO2000045883A1 (fr) * 1999-02-04 2000-08-10 Versamed Medical Systems Ltd. Systeme de ventilation portatif commande par ordinateur
GB2405799A (en) * 2003-09-15 2005-03-16 Vectura Ltd Dry powder inhaler incorporating a valve which is opened and closed by pressurized gas
US20090064997A1 (en) * 2006-02-21 2009-03-12 Jianhe Li Inhaler

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3537448A (en) * 1966-03-04 1970-11-03 Liston Fletcher Inc Therapeutic intermittent positive pressure respirator
WO1997006843A1 (fr) * 1995-08-16 1997-02-27 David Weintraub Dispositif de ventilation portatif commande par ordinateur
WO2000045883A1 (fr) * 1999-02-04 2000-08-10 Versamed Medical Systems Ltd. Systeme de ventilation portatif commande par ordinateur
GB2405799A (en) * 2003-09-15 2005-03-16 Vectura Ltd Dry powder inhaler incorporating a valve which is opened and closed by pressurized gas
US20090064997A1 (en) * 2006-02-21 2009-03-12 Jianhe Li Inhaler

Also Published As

Publication number Publication date
GB2540170A (en) 2017-01-11
GB201511942D0 (en) 2015-08-19

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