WO2016205986A1

WO2016205986A1 - Sample analyzer and control method thereof

Info

Publication number: WO2016205986A1
Application number: PCT/CN2015/082001
Authority: WO
Inventors: 高再兴; 刘军华
Original assignee: 深圳迈瑞生物医疗电子股份有限公司
Priority date: 2015-06-22
Filing date: 2015-06-22
Publication date: 2016-12-29
Also published as: CN112698046A; CN107532979A; CN112698046B; CN107532979B

Abstract

A sample analyzer and a control method thereof. The sample analyzer comprises: an apparatus body (9), a grabber (4) provided at the apparatus body (9) and capable of grabbing material and a transfer device (11) capable of driving the grabber (4) to move. The apparatus body (9) is provided with loading position at which can be installed a material container (5) including plural first storage positions (12), and a buffering position at which can be installed a material buffer container (6) including plural second storage positions (13). The grabber (4) has a buffering transfer process in which the grabber (4) transfers the material in the first storage position (12) to the second storage position (13). By adding a material buffer container, after a customer completes replacement loading of reaction vessels, a large number of reaction vessels can be provided for use within the apparatus, enabling an increased continuous testing time after once loading the entire apparatus, reducing the frequency of manual operation and increasing testing efficiency.

Description

Specification Name of Invention: Sample Analysis Apparatus and Control Method Therefor

[0001] This application relates to the field of sample analysis, and more particularly to a sample analysis device for sample detection using disposable consumables.

[0002]

BACKGROUND

[0004] A sample analysis device such as a chemiluminescence immunoassay analyzer uses a disposable reaction cup or the like for sample detection, and the number of loadings of the new reaction cup affects the continuous test of the whole machine test and the standby time.

[0005] The existing sample analysis device adds the cup box filled with the reaction cup to the machine at one time, and there are two disadvantages: 1. When a batch of tests is not finished but the new reaction cup is used, the whole machine must be suspended for testing and waiting for labor. After restarting the new cup box, restart the operation. If the replacement cup is long, the sample in the test may affect the sample test result, and even the test is invalid due to the interruption of the test, which increases the manual processing time and cost; After a batch of tests, there is a new reaction cup left in the cup box but the quantity is not enough to support the next batch of test 吋. The cup box needs to be replaced or replaced after the middle of use. It will also be due to the reaction cup during the test. The test is suspended after use, affecting the continuity of the test and the test results.

[0006]

SUMMARY OF THE INVENTION

The present invention provides a new sample analysis device and a control method thereof.

[0009] The present invention provides a sample analysis device sample analysis device, including a body, a gripper capable of grasping consumables disposed in the body, and a transfer device capable of driving the gripper, the machine Having a loading position capable of mounting a consumable container having a plurality of first storage locations, the body further having a cache bit capable of mounting a consumable cache container having a plurality of second storage locations, the gripper having a cache The movement stroke, in the cache movement stroke, the gripper transfers the consumables in the first storage position to the second storage position.

[0010] The gripper can have a plurality of other strokes, including a stroke to transfer consumables in the first storage location to the reaction tray and a stroke to transfer consumables in the second storage location to the reaction tray. [0011] The first storage location of each consumable container, the number of second storage locations of the consumable buffer container, and, preferably, is greater than the number of consumables required for a batch of tests.

[0012] The loading position has at least one consumable container, and the cache bit has at least one consumable cache container. Of course, the load bit can also have at least two consumable containers; the cache bit can also have at least two consumable cache containers.

[0013] The consumable is a reaction cup.

[0014] the fuselage is provided with at least one drawer that is slidably engaged therewith, and the consumable container is loaded and

[0015] its corresponding drawer. Each drawer can be fitted with one or at least two consumable containers.

[0016] The sample analysis device further includes a reaction disk disposed in the body, the drawer has two parallel to each other, and the consumable buffer container is fixed to the body and located between the rear end of the drawer and the reaction disk. .

[0017] A sample analysis device control method, the sample analysis device is provided with a loading position capable of installing a consumable container, and the sample analysis device is further provided with a cache bit capable of installing a consumable cache container, and the method includes: a caching step, Dissipating consumables within the consumable container into the consumable buffer container.

[0018] The consumable container is normally locked, and the controlling method further comprises the following steps: detecting the quantity of the consumables in each consumable container, and when the quantity of the consumables in the consumable container is less than a predetermined value, releasing the consumable container The locking allows the consumable container to be removed for replacement. Lock as electromagnetic lock. The predetermined value is 0 or other preset value.

[0019] In the buffering step, the consumable cache container is full or each of the consumable containers is empty, and the transfer is stopped.

[0020] The consumable container is replaceable and can be directly detachably mounted to the loading position. The consumable container can also be mounted on a carrier that cooperates with the fuselage. The carrier can be slidably engaged with the body, or can be rotated and fitted, and the carrier can be placed inside the fuselage; after the replacement, the carrier can be taken out from the inside of the fuselage.

[0021] The beneficial effects of the present invention are: Adding a setting of a consumable buffer container, fully utilizing the internal space of the analysis device under a limited operating space limitation, and supporting the replacement of the reaction cup in the test at a smaller space and cost Downtime, and the number of cuvettes available in the machine is more, the sustainability test after one cup is longer, the manual operation is reduced, and the test efficiency is improved.

[0022]

BRIEF DESCRIPTION OF THE DRAWINGS 1 is a schematic perspective view showing the sample analysis device of the present embodiment;

2 is a schematic structural view of another perspective of the present embodiment;

3 is a schematic structural view of a consumable cache container of the present embodiment;

4 is a schematic structural view of a consumable container of the present embodiment.

[0028]

DETAILED DESCRIPTION

[0030] The present invention will be further described in detail below with reference to the accompanying drawings.

[0031] The sample analysis device of the present invention is exemplified by an immunoanalyzer. The immunoanalyzer adds a cuvette buffer position when the disposable storage space of the new cuvette is limited in the space layout of the whole machine, and the immunoanalyzer can With the loading position, one or more drawers can be installed in the loading position, and the consumable container can be installed in the drawer, so that the loading and unloading of the consumable container can be realized by pushing and pulling the drawer. The storage capacity of the consumable container is designed to the maximum capacity according to the layout of the whole machine. There is an area between the rear of the drawer and the other components of the immunoanalyzer. The rear of the drawer is adjacent to other components. The size of the drawer directly determines the size of the consumable container. To avoid interference between the drawer and other components, it is necessary to limit the volume of the consumable container. The capacity of the consumable container is limited. To increase the capacity of the whole reaction cup, a fixed consumable buffer container is designed for this area. The addition of the cuvette buffer container allows the customer to replace the consumable container, and the number of cuvettes available in the machine is large. The sustainability test after the cup is completed for a longer period of time, reducing manual and frequent operations.

[0032] As shown in FIGS. 1 to 4, the immunoanalyzer includes a body 9, a reaction disk 10, a gripper 4, and a transfer device 11.

The reaction disk 10 is rotatably disposed in the body 9. The transfer device 11 drives the gripper 4 to grab the consumables and realize the transfer of consumables between different stations, such as the existing gripper robot. The body 9 is provided with a loading position, and the loading position is provided with two drawers slidingly matched with the body. The two drawers are respectively defined as a first drawer 1 and a second drawer 2, and each drawer is provided with a consumable container 5, Each consumable container 5 has a plurality of first storage locations 12 that can accommodate the cuvette 8, such as a conventional cup cartridge. A cache bit is also fixed to the body 9, and a cache buffer container 6 is mounted in the cache position. The consumable buffer container 6 has a plurality of second storage locations 13 capable of accommodating the cuvette. A consumable container can also be set in one drawer, or multiple consumable containers can be set.

[0033] The front of the fuselage facing the operator is provided with a front door 3 that can be opened and closed, two drawers are juxtaposed at the front, and the consumable buffer container 6 is located at the rear of the two drawers and other components of the immunoanalyzer Between 7, Located between the drawer and the reaction tray 10. Using 吋, the front door 3 is smashed, the first drawer 1 and the second drawer 2 are respectively pulled out and put into the cup box as a consumable container, and the two drawers are pushed in, the 吋 cup box is filled with the reaction cup, the consumable buffer container 6 no reaction cup, the gripper 4 is located above the cup box.

[0034] Starting the operation software of the immune analyzer, automatically resetting the whole body of the immune analyzer. If the operation of the whole machine is faulty, you need to manually reset. Click the whole machine icon in the software interface to enter the system reset interface. Click the system reset icon to reset the whole machine. During the resetting process, the gripper 4 detects the number of cuvettes in the cup cartridge in the first drawer 1, the cup cartridge in the second drawer 2, and the consumable buffer container 6, and reads the number of cuvettes into the software. Click the consumable management icon to enter the consumable management interface. The margin column of the drawer cuvette and consumable buffer container cuvette icon shows the cuvette balance in the cuvette and consumable buffer container respectively. If the cuvette balance of the first drawer cup or the cuvette balance of the second drawer cup is 0, the cup of the first drawer 1 or the second drawer 2 is prepared to be replaced. Snoring the front door 3, manually pulling out the first drawer 1 or the second drawer 2, if the drawer cannot be pulled out, the first drawer reaction cup button or the second drawer reaction cup button in the software interface can be manually clicked, and then Click the load icon to pull out the corresponding first drawer 1 or the second drawer 2, take the empty cup box in the first drawer 1 or the second drawer 2, and put the cup box carrying the full-box reaction cup 8 The first drawer 1 or the second drawer 2 is pushed in again, and the system automatically displays the cuvette balance of the first drawer 1 or the second drawer 2 as the maximum capacity value of the cup, and closes the process in which the front door 3 completes the change of the number of the cups.

[0035] According to the situation of the resetting cup after the resetting, after performing the application test, the gripper preferentially grabs the reaction cup on the consumable buffer container, and then grabs the second drawer cup box in turn after the consumable buffer container reaction cup is used. The upper cuvette is used, and finally the cuvette in the first drawer cup box is grasped. When a batch of tests is finished, the system automatically performs the gripping of the cuvette on the cup box into the consumable buffer container until the consumable buffer container There are no new cuvettes in the full or two cups.

[0036] In another embodiment, during the test, the grabber is idle, and the grabber first transfers the cuvette from the load position to the cache bit buffer for use; during the test, the load position is used first. Cup, when the loading position reaction cup is used up, the operator is directly prompted to replace the consumable container, and a new reaction cup is added, and the cuvette used for the test is taken from the buffer position, thereby ensuring that the test is not interrupted during the replacement of the consumable container. Continuous continuous testing, the same can be added before the downtime test, a larger number of cuvettes can be added at a time than the conventional instrument (the cache bit is also filled) to increase the test off-site, to meet more test Cup demand. The grabber idle time refers to the time when the grabber is in a static waiting state. Cache time means: The picker starts at the current position and transfers the new cuvette in the consumable container to the time required for the consumable cache container.

[0037] The system compares the cache time and the crawler idle time. If the cache time is smaller than the crawler idle time, the cache operation is performed, that is, the crawler transfers the reaction cup from the consumable container to the consumable cache container. The remaining amount of the consumable buffer container is increased by 1; until the consumable buffer container is full (ie, the remaining amount reaches the set value), and then the conventional gripping operation is performed, that is, the new reaction cup is directly transferred to the consumable container.

[0038] The gripper can set the sensor, operate the crucible, the gripper grabs the cuvette and lowers the cuvette, the state of the sensor changes, and the change is counted.

[0039] For an immunoassay analyzer, a consumable container and a consumable buffer container can hold a consumable that is discarded after use in the test cartridge and including after use, including but not limited to a cuvette, a flow tube, or a TIP head, typically a tubular structure Correspondingly, the consumable container and the cache container may have matching hole-shaped storage positions.

[0040] For the immunoassay analyzer, a consumable buffer container is added between the existing consumable container and the existing reaction tray, and continuous sample testing between long turns is realized. The consumable buffer container can also be flexibly placed elsewhere in the immunoanalyzer, such as an immunoassay analyzer and a magnetic separation disc. The consumable buffer container can also be placed between the consumable container and the magnetic separation disc. After a batch of tests, you can use the consumables in the consumables container and then use the consumables in each consumable container. You can also use the consumables in each consumable container before using the consumables in the consumables. Or use the consumables in a consumable container and use consumables to cache the consumables inside the container.

The sample analysis device of the present invention may be an immunoanalyzer or a sample analysis device for sample processing such as a biochemical analyzer.

The above is a further detailed description of the present invention in conjunction with the specific embodiments. It is not intended that the specific embodiments of the invention are limited to the description. It is to be understood by those skilled in the art that the present invention may be made without departing from the spirit and scope of the invention.

technical problem

Problem solution

Advantageous effects of the invention

Claims

Claim

[Claim 1] A sample analyzing device comprising a body, a gripper capable of gripping a consumable provided on the body, and a transfer device capable of driving the gripper, wherein the body is provided with Mounting a loading position of a consumable container having a plurality of first storage locations, wherein the body is further provided with a cache bit capable of mounting a consumable cache container having a plurality of second storage locations, the crawler having a cache The movement stroke, in the cache movement stroke, the gripper transfers the consumables in the first storage position to the second storage position.

[Claim 2] The sample analyzing device according to claim 1, wherein the loading position has at least

A consumable container, the cache bit having at least one consumable cache container.

[Claim 3] The sample analysis device according to claim 1, wherein the consumable is a reaction cup

[Claim 4] The sample analyzing device according to claim 1, wherein the body is provided with at least one drawer slidably fitted thereto, and the consumable container is loaded with the drawer corresponding thereto.

[Claim 5] The sample analysis device according to claim 4, further comprising a reaction tray, the drawer having two parallel to each other, the consumable buffer container being fixed to the body and located in the drawer Between the back end and the reaction tray.

[Claim 6] The sample analysis device according to claim 1, wherein the first storage location of each of the consumable containers, the second storage location of the consumable buffer container, and the consumables required for a batch of tests quantity.

[Claim 7] A method of controlling a sample analyzer, wherein the sample analyzer is provided with a load position capable of mounting a consumable container, wherein the sample analyzer is further provided with a cache position capable of installing a consumable cache container. Includes:

a caching step of transferring consumables within the consumable container into the consumable cache container.

[Claim 8] The control method of the sample analyzer according to claim 7, wherein the consumable container is normally locked, and further includes:

The replacing step detects the quantity of consumables in each of the consumable containers, and when the number of consumables in the consumables container is less than a predetermined value, the locking of the consumable containers is released.

[Claim 9] The method of controlling a sample analyzer according to claim 7 or 8, wherein In the buffering step, the consumable cache container is full or each of the consumable containers is empty, and the transfer stops.