JP5276189B2 - Microplate pickup device and microplate supply / recovery device - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a pickup device and a microplate supply and collection device for solving a problem that a body part and a cover can disengage and fall when a microplate to be constituted of two units to be separated into a cover part and a body part is lifted since the microplate is lifted up by simply holding the side of the microplate with two arms when the microplate is lifted up and taken out in the conventional technology. <P>SOLUTION: A pickup device includes a body part and a cover part, and takes up by holding a rectangle microplate in which each of the body part and the cover part can be held from the side, and includes: a pair of holding arms which hold the microplate from right and left by bringing the microplate into contact with the body part with one holding arm and bringing the microplate into contact with the cover part with the other holding arm; an opening/closing drive part which performs opening/closing control of the pair of holding arms; a lifting drive part which lifts up and down the pair of holding arms in the vertical direction; and a pickup control part which controls operations of the opening/closing drive part and the lifting drive part. <P>COPYRIGHT: (C)2012,JPO&amp;INPIT

Description

  The present invention relates to a microplate pick-up device and a microplate supply / recovery device used in a processing apparatus that performs predetermined chemical reaction inspection, analysis, and other operations using a microplate.

  In the drug discovery screening field, the biotechnology field, etc., various tests such as biochemical reaction tests of substances are performed. In these tests, a microplate having a plurality of hole-shaped containers (wells) in one plate is used as a container for storing a chemical solution and a specimen for performing culture and biochemical reaction. Further, since these tests are often systematically performed on a large number of samples, processing such as dispensing operation and component analysis is usually performed using a large number of microplates. The present invention relates to a handling apparatus for various microplates that efficiently stores, removes, and transports the microplate to a target position in a processing apparatus that uses the microplate for these tests, such as an assay processing apparatus. Is.

  Here, “assay processing” means that a composition required for a chemical reaction is mixed in an inspector or the like and reacted under a certain condition to detect what is produced or consumed, and quantified. To do. These assay processes were performed manually for each specimen in the initial stage, but recently, in order to process a large number of specimens at high speed, a high-speed processing apparatus that automates these processes has been developed. .

  As a prior art of such an apparatus for handling microplates, microplates are individually stored in a storage shelf on which a plurality of microplates can be placed, and if necessary, a plate transport mechanism of an overhead traveling robot type is used. There has been proposed a microplate processing apparatus that takes out one by one and transfers it to a dispensing stage, and returns the microplate after the dispensing operation to a storage shelf (see Patent Document 1).

  In addition, since the technique disclosed in Patent Document 1 has a problem that the lid of the microplate cannot be efficiently attached and detached, another transport technique has been proposed to solve this problem (Patent Document). 2). In the technique of Patent Document 2, a conveyor type microplate transport mechanism is used, and the microplate is transported on the conveyor. On the upstream side of the conveyor, a device for removing the lid is provided at a position higher than the conveyor, whereby the lid is removed. The microplate with the lid removed is transported to a predetermined dispensing position and subjected to a dispensing process on the conveyor. After the dispensing process is completed, the microplate is further transported downstream, and the previously transported lid is covered. . Thereafter, the microplate with the lid is collected by the collection unit.

Furthermore, a microplate-with-lid supply device that takes out and transports microplates one by one from a storage section that stores a large number of microplates with lids is also proposed (Patent Document 3). In Patent Literature 3, after a microplate with a lid is stacked and stored in the first stock part, all the microplates stored in a stacked manner are provided below the first stock part. The prior art is disclosed in which the stacked microplates are moved one by one in order from the top.

Japanese Patent Laid-Open No. 11-223636 JP-A-2005-300200 JP-A-2005-249648

  In an apparatus that handles such a microplate, various processes such as an incubation process and an analysis process are performed in addition to a dispensing process, and a large number of microplates are used in these processes. Therefore, it is required to transport the microplate quickly and accurately according to various processing requirements. In order to meet these requirements, there are various problems in the prior art as described above.

  For example, in the technique of Patent Document 1, as pointed out in Patent Document 2, there is a problem that a mechanism for removing the lid becomes complicated. In addition, since the dispensing stage (dispensing stand) is in the middle of the conveyance path, there is a risk that the overhead traveling robot may contaminate the microplate being dispensed. More specifically, when transporting the microplate to a processing device downstream of the dispensing table, the overhead traveling robot moves over the microplate placed on the dispensing table with the lid removed. Therefore, dust such as dust may fall on the microplate placed in a state where the lid is opened on the dispensing table and may be mixed into the specimen.

  In the technique disclosed in Patent Document 2, a microplate is placed on a conveyor for conveyance, and the microplate in the middle of conveyance is stopped on the conveyor to perform a dispensing process. For this reason, it is impossible to jump over the microplate previously placed on the conveyor and transport the microplate earlier than that. Therefore, the other microplates cannot be transported before the dispensing stand until the dispensing process is completed, and the transportation throughput of the other microplates is extremely affected by the dispensing process speed. To drop.

  Furthermore, Patent Document 3 which is an apparatus that stores and stores microplates and supplies or collects microplates one by one to the transport apparatus also has various problems. Thus, if the microplates are stacked and stored and can be supplied one by one as required, there is an advantage that the microplates can be stored more efficiently than when stored in the storage shelf. is there. However, in the technique disclosed in Patent Document 3, when the microplate is first stored in the first stock portion, the microplate must be inserted from above the opening at a high position. The labor load is large. In addition, since the stacked microplate is moved from the first stock portion to the second stock portion and then the microplate moved to the second stock portion is taken out in order from the top, the minimum configuration However, the first stock part and the second stock part are required, and there is a problem that the entire apparatus becomes large and complicated.

  Furthermore, in the technique described in Patent Document 3, when lifting and taking out a microplate composed of two units separated into a lid and a main body, the side surface of the microplate is simply sandwiched between two arms. Since it was lifted, there was a risk that the main body and the lid would come off and fall when lifting.

  Furthermore, in the prior art, since the microplate placed on the shelf had to be grasped and taken up from the side, the control for taking out the microplate on the shelf by the robot was complicated.

  Another object of the present invention is to provide a microplate pick-up device that can lift and take out a microplate without separating the lid portion and the main body portion.

  Still another object of the present invention is to provide a microplate supply / recovery device capable of efficiently storing and taking out stacked microplates.

  Still another object of the present invention is to provide a cassette for microplate that can store microplates in a stacked manner and can be easily mounted on a microplate supply and recovery device.

A first aspect of a microcassette pickup device according to the present invention includes a main body portion and a lid portion, and picks up and picks up a rectangular microplate that can sandwich the main body portion and the lid portion from the side surfaces. When the side surface of the microplate is sandwiched and sandwiched, a pair of gripping the microplate from the left and right by abutting the body portion with one sandwiching arm and the lid portion with the other sandwiching arm A pair of sandwiching arms, an opening / closing drive for driving the pair of sandwiching arms to open / close, a lifting / lowering driving unit for lifting / lowering the pair of sandwiching arms in the vertical direction, and controlling the operations of the opening / closing driving unit and the lifting / lowering driving unit. And a pickup control unit.
In this mode, a pair of clamping arms are separately sandwiched from the left and right so that the lid and main body of the microplate are pressed against each other, so that the lid and the main body are not separated when lifting the microplate. It is a thing.

Another aspect of the pick-up device for a microcassette according to the present invention is characterized in that the pair of holding arms hold the main body portion and the lid portion obliquely at different heights.
In this aspect, the height of the microplate contact portion of each clamping arm is made different so that each clamping arm can securely grip the lid and the main body. As a result, the microplate is sandwiched and lifted by pressing the lid portion and the main body portion obliquely.

  Another aspect of the pick-up device for a microcassette according to the present invention is characterized by further comprising a detection sensor for detecting the height position of the sandwiched microplate.

  In another aspect of the microcassette pickup device according to the present invention, the microcassette pickup device further includes a pair of holding members that hold the bottom surface of the microplate from side surfaces that are orthogonal to the pair of holding members.

  In another aspect of the pick-up device for a microcassette according to the present invention, the pick-up control unit lifts the micro plate slightly by the pair of holding portions, and then the bottom surface of the micro plate is moved by the pair of holding members. It is characterized by controlling to hold.

A first aspect of the microplate supply / recovery device according to the present invention includes a lift unit that includes a lift member that lifts a stacked microplate from the bottom, an opening through which the lift member can pass, and a top surface. Provided with an opening through which the microplate can pass, a cassette storage base to which a cassette for stacking and storing the microplates can be mounted, and the microplate pickup device, on the lift member The laminated microplate is gripped by the microplate pickup device .

Another aspect of the microplate supply / recovery device according to the present invention is characterized in that a plurality of the cassettes can be placed on the cassette storage base.

  In another aspect of the microplate supply / recovery device according to the present invention, the elevating part is disposed at a position inscribed inside the cassette storage base, and the cassette storage base is rotated to rotate each of the attached units. The cassette is configured to abut against the front surface of the elevating unit.

  Another aspect of the microplate supply / recovery device according to the present invention is characterized in that the elevating member is provided in a central portion of the cassette storage base.

In another aspect of the microplate supply / recovery device according to the present invention, the cassette includes a side surface support frame that supports the side surface of the microplate from three directions, a bottom surface support frame portion having an opening smaller than the microplate, and the microplate. An upper surface support frame portion having an opening larger than the plate and a short door portion for supporting the microplate from the remaining one direction of the side surface support frame are provided.

In another aspect of the microplate supply / recovery device according to the present invention, the cassette is locked in a state in which the bottom support frame part is lowered by gravity when it is lifted and protrudes from the lower side and the door part is closed. And a door lock pin that unlocks the door by lifting it upward, and an elastic member that biases the door in the closing direction.

In another aspect of the microplate supply / recovery device according to the present invention, the cassette includes the side support frame including a plurality of support rods connecting the upper surface support frame portion and the bottom surface support frame portion. .

In the microcassette supply / recovery device according to the present invention, a cassette capable of stacking and storing microplates can be set as it is with respect to the cassette storage portion. In addition, since a plurality of cassettes can be set in the cassette storage portion and the cassette storage portion can be structured to be rotatable, a large number of microplates can be efficiently stored in a relatively small space. . Moreover, since the cassette storage part is in a low position,
Even a heavy cassette can be easily set in the cassette storage section, and the workload of the cassette can be greatly reduced.

The pick-up device according to the present invention abuts the lid portion of one of the two left and right sandwiching arms when the side surface of the microplate composed of the lid portion and the body portion is sandwiched and lifted, and the other side abuts the body portion. Therefore, the lid portion and the main body portion are lifted in a state of pressing and meeting each other. As a result, it is possible to prevent the lid and the main body from separating when the microplate is lifted.

The microcassette apparatus of the present invention stores microplates stacked by three-side support frames and small doors on the entire surface, and has openings through which lift pieces can pass on the bottom surface and the entire surface. By providing an opening through which the cassette can pass, the cassette can be directly set in the microcassette supply and recovery apparatus of the present invention. This cassette can open the entire door, and can easily stack and store the microplates. By using this cassette, it is possible to greatly reduce the burden of storing and transporting the microcassette.

It is a perspective view which shows an example of the analysis processing system using a shuttle type conveying apparatus . FIG. 2 is a partially cutaway view showing the inside of a supply and recovery unit of the analysis processing apparatus shown in FIG. 1. It is a top view of the analysis processing apparatus shown in FIG. It is the side view and top view which show an example of the microplate handled with a shuttle type conveyance apparatus etc. It is the perspective view which expanded the delivery stand of the shuttle type conveying apparatus shown in FIG. 1, and a shuttle conveyance part. It is a perspective view which shows the process sequence until it lifts and takes out the microplate mounted on the delivery stand, and it descends to the position below a delivery stand. FIG. 3 is a side view of the shuttle type transport device 10 with a part omitted. It is the figure which looked at the shuttle type conveying apparatus 10 from the A-A 'line direction of FIG. It is a perspective view which shows the other Example which fixes the support plate of a delivery stand. It is a partially cutaway perspective view showing a state where only one cassette in which a large number of microplates are stacked and stored is set on a rotary storage base. It is a perspective view of the state which removed the cassette and cut off the rotation storage stand. It is a typical top view in the state where six cassettes were set in the rotation storage part. It is a partially cutaway perspective view showing the internal structure of the pickup device. It is a side view which shows typically the clamping state of the microplate by a pick-up apparatus. It is a perspective view which shows an example of the cassette for microplates used for a microplate supply collection | recovery apparatus . It is a partial expanded side view which shows the relationship between a door lock pin and a stopper. It is a top view which shows the conveyance condition of a horizontal rotation type robot . It is the top view and side view of a storage shelf . It is a basic functional block diagram which shows an example of the control apparatus which controls a conveyance apparatus , a microplate pick-up apparatus, and a microplate supply and recovery apparatus. It is a flowchart which shows an example of the conveyance control processing procedure of the to-be-conveyed object by a shuttle type conveying apparatus .

  FIG. 1 is a perspective view showing an example of an analysis processing system that performs processing such as drug discovery screening using a shuttle type transport device and a microplate supply device according to an embodiment of the present invention. FIG. 2 is a perspective view showing an internal structure of the microplate supply / recovery unit 40 of the system shown in FIG. FIG. 3 is a plan view of the analysis processing system 1 shown in FIGS. 1 and 2, and FIG. 4 is a side view and a plan view showing an example of a microplate used in these apparatuses.

[About microplate structure]
First, the microplate 95 handled in the present invention will be described with reference to FIG. The structure and size of the microplate 95 are standardized to a certain size and shape. As described above, the analysis processing system 1 is a device that drops and mixes a sample with a reagent and monitors the sample, and the microplate used for the sample is a sample so that a large number of samples can be simultaneously analyzed. There are many small well-like holes (wells) that can be injected. FIG. 4 shows an example of such a microplate, which is a plastic 85.times.12 provided with a total of 96 small hole-like containers (hereinafter referred to as “well 99”) of 12 horizontal × 8 vertical. A box-type microplate of 5 × 127.8 mm is shown. 4A is a side view of the microplate, and FIG. 4B is a plan view with the lid removed. As shown in FIG. 4A, the microplate 95 includes a microplate body 96 and a lid. 98. The microplate main body 96 has a bottom surface 97 having a peripheral edge slightly projecting from the main body and substantially the same width as the lid 98. The thickness “t” of the microplate 95 varies depending on the type of microplate.

In the field of drug discovery research related to the development of synthetic medicines and biochemical medicines, hundreds of thousands and millions of specimens are subjected to high-throughput screening (High Throughput Screening). Therefore, in addition to the microplate 95 having 96 wells 93 as shown in FIG. 4, in order to process a larger amount of specimens, the outer dimensions are 384 well or 1534 well on the microplate of the same size as FIG. 4. Some are also being developed. In the analysis processing system, since many of these microplates are used simultaneously, it is required to take out the microplates 95 from the storage device 40 one by one and transport them to a target position at a high speed. These microplates 95 are placed on the shelf 120 for a certain period of time as needed after the sample or reagent is dispensed into the well 99 by the dispensing processing device 70, or the moisturizer 14.
After the incubation process is performed using 0 or the like, analysis processes are performed by various analyzers 130 such as a visible light absorption spectrum analyzer, a fluorescence analyzer, a chemiluminescence analyzer, and a radioisotope scintillation counter. For this reason, the analysis processing apparatus is required to deliver the microplate 95, the supply / recovery apparatus 40, the dispensing processing apparatus 70, the shelf 120, the various analyzers 130, the moisturizer 140, and the like at high speed.

[Overall configuration of analysis processing system 1]
The analysis processing system 1 supplies a microplate 95 that is unused or injected with a specimen, collects and stores the used microplate 95, and picks up the microplate 95 one by one and transports it from the supply and recovery section 40. The first pick-up unit 50 that moves to the delivery table R1 of the unit 10 or from the delivery table R1 to the supply storage unit 40, and the microplate 95 placed on the delivery tables R1 to R4, one by one on the other delivery table A transport system 10 for transporting, a dispensing plate 70 for picking up the microplate 95 placed on the delivery table and placing it on the dispensing table to dispense a chemical into the well 99, and a shelf 120 for placing the microplate. The analyzer 130, the moisturizer 140, and the microplate are picked up between the delivery table R4, the shelf 120, and the various devices 130 and 140. And a horizontal rotating type transport robot 110 to feed.

  In the analysis processing system 1, how the microplate 95 is conveyed can be freely set according to the processing purpose. In the analysis processing system 1, for example, an unused or dispensed microplate 95 is taken out from the supply / recovery unit 40 and conveyed to a dispensing stage (dispensing stand) 75 to perform a dispensing process. It is possible to perform an analysis process after an incubation process or the like, or return to the collection processing apparatus immediately after the dispensing process. The procedure for transporting the microplate can be transported in a predetermined order according to the process by programming the control unit in advance according to the processing mode.

[Shuttle type transfer device]
The shuttle type transfer device transfer device 10 that transfers the microplate 95 from one transfer table to another transfer table will be described. As shown in FIGS. 1 to 3, the shuttle type transport device 10 includes transport paths La to Lb, a shuttle transport unit 11 that moves along the transport paths L1 to L3, and delivery tables R1 to R4. 1 to 3 show three shuttle-type transfer devices that reciprocate.

  FIG. 5 shows an enlarged perspective view of the delivery table R1 and the shuttle transport unit 11 of the shuttle type transport apparatus 10 shown in FIG. The delivery table R1 is provided on the transport path, and the shuttle transport unit 11 can move under the delivery table R1. The shuttle transport unit 11 includes a transport platform 12 that can be moved up and down. In the raised position, the shuttle platform 12 can be lifted so that the transport platform 12 is higher than the delivery table R1. A total of three microplates 95 can be placed for each transport path L1 on the delivery table R1 of the present embodiment.

  The delivery table R <b> 1 is composed of small support plates 21 for supporting the four corners of the microplate 95. One microplate 95 is supported by the four support plates 21. The support plate 21 is provided with a plurality of elongated conical positioning pins 22 for accurately positioning the microplate 95 at a predetermined position. Since the positioning pin 22 has a conical shape, when the microplate 95 is placed, the positioning pin 22 descends along the oblique peripheral wall of the positioning pin and is accurately positioned and held.

  The support plate 21 is supported by the support column 20 so as to slightly protrude toward the transport paths La to Lc. Thus, since the delivery table R2 is composed of the small support plates 21 that support the four corners, the opening 23 is formed in the upper part of each of the transport paths La to Lc of the delivery table R2, and the shuttle transport unit 11 is formed. It is possible for the transfer table portion 12 to extend from directly below the delivery table R2 through the opening 23 to above the delivery table R2. Therefore, when the microplate 95 is placed as in the transport path Lb, the microplate 95 is lifted above the delivery table R2 by raising the transport platform 12 of the shuttle transport unit from directly below Lb. be able to. The shuttle transport unit 11 can move along the transport path with the microplate 95 lifted as described above, and lifts the microplate 95 and removes it from the delivery table R2.

  When the microplate 95 is placed on the delivery table, the shuttle transport unit 11 is moved to the center of the delivery table while the transport table 12 on which the microplate 95 is placed is extended upward. Lower to the bottom of the delivery table. As a result, the transport table 12 descends to the bottom of the delivery table via the bottom opening 23, but the microplate is supported by the support plates 21 at the four corners, so that the microplate can be placed on the delivery table. . This point will be described later.

  Further, the support column 20 is provided on both sides of the transport paths La to Lb so that the support 20 can pass between the support columns 20 with the shuttle transport unit 11 supporting the microplate 95. Is arranged. Therefore, the shuttle transport unit 11 can move under the delivery tables R1 to R4 with the microplate 95 placed on the transport table. Thus, even if the microplate 95 is placed on any of the delivery tables R1 to R4, the shuttle transport unit 11 moves below the delivery tables R1 to R4 and freely transports the microplate 95. Is possible.

  FIG. 6 shows a processing procedure until the microplate 95 placed on the delivery table R4 is lifted and taken out and lowered to a position below the delivery tables R4 to R1. First, as shown in FIG. 6A, the shuttle transport unit 11 moves below the delivery table R4. Next, the air cylinder 17 is driven to raise the transport table 12 and lift the microplate 12 (b). In this state, it moves between the delivery tables R4 and R3 (c), lowers the transport table 12, and holds the microplate 95 at a position lower than the delivery tables R3 and R4. Thus, the transfer plate R1 to R4 and the dispensing table 75 can be freely moved and conveyed, so that the microplate 95 can be conveyed to any position on the conveyance path La.

  With reference to FIG. 7 and FIG. 8, a conveyance processing procedure for taking out and conveying the microplate 95 from the delivery table will be described. FIG. 7 is a side view in which a part of the shuttle type transport device 10 is omitted. FIG. 8 is a view of the shuttle type transport device 10 as seen from the direction of the line A-A ′ of FIG. 7. In the transport paths La to Lc, a linear guide rail 26 is laid on the base 25, and the linear guide 13 of the shuttle transport unit 11 is slidably attached thereto. The linear guide 13 is provided with a shuttle motor 15 (see FIG. 8) to which a gear 14 is attached, two rollers 16, and an air cylinder 17 provided upward. The air cylinder 17 drives the lifting rod 18 up and down. The transport table 12 is fixed to the upper end of the lifting rod 18, and the transport table 12 moves up and down according to the vertical movement of the lifting rod 18.

  A linear timing belt 27 is fitted between the gear 14 and the two rollers 16, and both ends of the timing belt 27 are fixed to belt fixing portions 29 provided at both ends of the base 25. Since the timing belt 27 has a smooth surface, a corrugated shape is formed on the back surface, and meshes with the gear 14, when the shuttle motor 15 rotates, the shuttle conveyance unit 11 moves along the conveyance path La according to the rotation of the gear 14. Runs along ~ Lc. It is desirable to use a stepping motor as the self-propelled shuttle motor 15 and to accurately control the rotation by a pulse signal. By controlling the rotation of the shuttle motor 15, the shuttle transport unit 11 can freely move to the target position and stop.

  A procedure for taking out the microplate 95 from the delivery table R1 by the shuttle transport unit 11, opening the lid 98, and transporting the microplate 95 will be described. When the microplate 95 of the delivery table R1 is taken out by the shuttle transport unit 11, the shuttle transport unit 11 moves to just below the delivery table R1, as shown in FIG. In this state, as shown by the wavy line in FIG. 8, the transport table 12 is below the delivery table R1. Thereafter, as shown by the solid line in FIG. 8, the conveyance base 12 is lifted upward by driving the air cylinder 17. Thereby, the microplate 95 is lifted to a position higher than the positioning pins 22 of the delivery table R1. In this state, the shuttle transport unit 11 is slightly moved in the left direction in FIG. 7, the microplate 95 is taken out from the delivery table R <b> 1, and is stopped under the lid adsorber 28. In addition, in order to show the structure of the shuttle type transport apparatus 10 in an easily understandable manner, the lid adsorber 28 is not shown in FIGS.

  The lid suction device 28 includes a plurality of suction pads 31 and a confirmation sensor 32 provided on the attached lifting rodless cylinder 30. When the suction pad 31 is lowered by the lifting rodless cylinder 30 and the lid portion 98 of the microplate is sucked, it is detected that the degree of decompression is changed and sucked. By raising the suction pad 31 in this state, the lid portion 98 is lifted and the lid is opened. The confirmation sensor 32 detects whether or not the lid is correctly closed based on the position of the lid. Attachment of the confirmation sensor 32 is optional.

  When the microplate body 96 with the lid 98 removed is placed on the delivery table R2, the shuttle transport unit 11 is moved to the center of the delivery table R2 as it is, and the transport table 12 is lowered, The microplate body 96 is placed on the delivery table R2. When the microplate body 96 is transported to another delivery table R3 or R4, after the lid 98 is adsorbed by the lid adsorber 28 as shown in FIG. 7, the transport platform 12 on which the microplate body 96 is placed is moved. It is lowered so as to be lower than the delivery tables R1 to R4 and the dispensing table 75. Thereafter, the shuttle transport unit 11 is transported through the lower side of the delivery table and the like to transport to the target position.

  In addition, when transporting from the delivery table R1 to the delivery table R4 without performing the dispensing process, it is not necessary to remove the lid portion 98, so that it is transported at the position of the lid suction device 28 without removing the lid portion 98. The platform 12 is lowered, and the shuttle transport unit 11 is moved under the delivery tables R2, R3 and the dispensing table 75 to the position before the delivery table R4. Thereafter, the transport table 12 is raised to a height above the delivery table R4 and moved to the center of the delivery table R4, and then the transport table 12 is lowered to place the microplate 95 on the delivery table R4. The microplate 95 placed on the delivery table R4 is picked up by the tip 112 of the arm 111 of the transfer robot 110 and transferred to the shelf 120 or other processing devices 130 and 140. In addition, the microplate 95 that has been processed is supported by the tip 112 of the arm 111 of the transfer robot 110, is lowered from above the delivery table R4, and is placed on the delivery table R4.

  When the microplate body 96 for which the dispensing process has been completed is returned to the delivery table R2, the shuttle transport unit lifts the microplate body 96 from directly below the delivery table and moves to the bottom of the lid adsorber 28. In this state, the suction pad 31 holding the lid 98 is lowered, and the lid 98 is placed on the microplate body 96.

  Since the dispensing process is performed with the lid 98 removed, a lid adsorber 28 is provided in front of the delivery table R2 for the dispensing process. The delivery table R4 is a delivery table for the microplate transported for other processes such as an incubation process, and a delivery board on which the microplate 95 on which the predetermined process is performed and the microplate on which the predetermined process has been completed is placed. It is. The dispensing process may be performed after a predetermined process such as incubation. In the embodiment shown in the present specification, a delivery table R3 is further provided in order to shorten the transport distance and increase the buffer function for absorbing the delay of the dispensing process as much as possible in such a case. In FIG. 7, a lid adsorber 28 is also provided in the vicinity of the delivery table R <b> 3 in order to enhance the function of removing the lid 98.

  As is apparent from the above description, according to the present invention, the microplate 95 is taken out from the delivery tables R1 to R4 and conveyed only by the raising / lowering operation of the shuttle conveyance unit 11 and the movement operation of the conveyance path. It can be placed on R1 to R4. Therefore, for example, even if the dispensing process is delayed and the microplate 95 is placed on the delivery table R2 or R3, the microplate 95 can be transported between the delivery table R1 and the delivery table R4. It becomes possible.

That is, according to the transport system of the present invention, processing by a single processing device is performed by a simple transport mechanism provided with a shuttle transport section having a transport base section that can be moved up and down and a delivery base at the top of the transport path. It becomes possible to prevent the delay of the time from becoming a bottleneck and delaying the transport of the microplate 95 to another processing apparatus on the same transport path. As described above, by providing a plurality of delivery tables according to the present invention in the vicinity of various processing apparatuses, even if the delivery table in the middle of the transport path is full, the microplate can be transported to a further delivery table. It becomes possible.
Therefore, the throughput of the shuttle type transport process can be greatly improved. Further, since the delivery table functions as a transport buffer, by providing a plurality of delivery tables according to the present invention, it is possible to further improve the transport throughput of one transport path. In particular, in the present invention, a simple structure in which a shuttle platform that moves up and down in the up and down direction is provided in the shuttle transport unit and a delivery table having a bottom opening is provided at the top of the transport path, thereby greatly increasing the transport throughput. The remarkable effect of improvement could be obtained.

  In the above description, a structure is shown in which the support plate 21 of the delivery tables R1 to R4 is supported by the support column 20, but as shown in FIG. 9, it is mounted at both ends of the conveyance path at a predetermined height. The support plate 20 may be provided so as to be fixed to the support frame 35. At that time, by providing a plurality of screw holes for attaching the support plate 21 to the support frame 35 at a predetermined interval, the support plate 21 can be attached at an arbitrary position, so that the installation position and the number of installations of the delivery table can be easily made. It can also be changed. Further, instead of the mounting frame 35, a wall having a predetermined height may be provided to fix the upper support plate 21.

  Moreover, in embodiment described above, although the example provided with three conveyance path La-Lc is shown, the number of conveyance paths may be one or three or more.

[Microplate supply and recovery equipment]
Next, the microplate supply / recovery device 40 will be described. FIG. 2 shows a part of the internal structure of the microplate supply / recovery device 40. FIG. 2 shows an example in which one microplate cassette 80 is set on the rotary storage base (cassette storage section) 43. The cassette 80 of FIG. 2 shows a state in which most of the microplate 95 has already been supplied and is almost empty. FIG. 10 is a partially cutaway perspective view showing a state in which only one cassette 80 in which a large number of microplates 95 are stacked and stored is set on the rotary storage base 43. FIG. 10 shows a state where the uppermost microplate 95 is lifted up to the position where the microplate 95 is taken out by the pickup device 50a.

  Although six similar cassettes 80 can be set on the rotary storage base 43, FIGS. 3 and 10 show a state in which only one cassette is set. FIG. 11 shows a perspective view in a state where the cassette 80 is removed and the rotary storage base 43 is cut out, and FIG. 12 shows a schematic plan view of a state in which six cassettes 80 are set in the rotary storage part 43. The rotary storage base 43 is held on a base part 42 fixed to the frame 41 of the supply and recovery part 40 so that it can be rotationally driven by a rotary motor (not shown). At the center of the base portion 42, a plate elevating portion 45 for lifting the entire microplate stacked in the cassette 80 from below is fixed. The plate elevating unit 45 includes a lift piece 46 that can be lifted by placing the entire microplate. The lift piece 46 is driven up and down by a ball screw 47 that is driven to rotate by a plate lift motor 49 (see FIG. 12).

  As can be seen from FIG. 10, the rotary storage base 43 includes four positioning fixing pins 43 a at the position where the cassette 80 is set. In the rotary storage stand shown in FIG. 10, six cassettes can be set. The rotary storage base 43 includes an opening (lift piece opening) 44 at a position corresponding to the bottom surface portion of the cassette 80, and when the rotary storage base 43 rotates, the lift piece 46 extends from the opening 44 to the rotary storage base 43. Evacuate below. After the rotary storage base 43 rotates and the cassette 80 on which the microplates to be taken out are stacked stops at the front of the plate lifting / lowering section 45, the lift piece 46 rises through the opening 44, and the cassette 80 starts from the bottom surface of the cassette 80. The entire microplate stacked in 80 is pushed up, and as shown in FIG. 10, the microplate 95 stacked in the uppermost stage is lifted to the pickup position by the pickup device 50a.

  The supply / recovery unit 40 is provided with a similar rotary storage base 43 on the pickup device 5b side, and can store a total of twelve cassettes 80. By setting the cassette 80 in which the microcassettes 95 are stacked, the microcassette 95 can be supplied to the delivery table R1. By setting the empty cassette 80 on the rotary storage table 43, the cassette 80 can be supplied from the delivery table R1. The collected microplates 95 can be stacked and stored in an empty cassette 80 in the order of collection. The plate elevating unit 45 is controlled to be pushed up by one each time the microplate 95 is taken out from the top, and is controlled to move down by one microplate each time the microplate 95 is returned to the cassette 80. By moving the lift piece 46 in the vertical direction in this way, the height is adjusted so that the uppermost microplate 95 in the cassette 80 is always at the take-out position or the return position by the pickup unit 50.

As can be seen from the above description, in the microcassette supply / recovery device of the present invention, a cassette capable of stacking and storing microplates in a cassette storage section can be set as it is. In addition, since a plurality of cassettes can be set in the cassette storage portion and the cassette storage portion can be structured to be rotatable, a large number of microplates can be efficiently stored in a relatively small space. . Further, since the cassette housing portion is at a low position, even a heavy cassette can be easily set in the cassette housing portion, and the work load on the cassette can be greatly reduced.

[Microplate pickup device]
Next, a micro pickup device that picks up the microplate 95 from the supply / recovery unit 40 and places it on the delivery table R1 or picks up the microplate 95 from the delivery table R1 and stores it in the cassette 80 of the supply / recovery unit 40 will be described. The overall appearance of such a pickup device is shown as a first pickup device 50 in FIG. 1, and its internal mechanism is shown in FIG. The internal structure and function of the first pickup device 50 will be described in more detail with reference to FIGS. 13 and 14. FIG. 13 is a partially cutaway perspective view showing the internal structure of the first pickup device 50, and FIG. 14 is a side view schematically showing how the microplate 95 is held by the first pickup device 50. is there.

  In the present embodiment, two microplate pick-up devices 50a and 50b for taking out the microplate 95 from the two rotary storage platforms 43 are provided. Since the microplate pickup devices 50a and 50b are the same, only the microplate 50a will be described below.

  At both ends of the microplate pickup device 50, cylinder support portions 52 attached to the frame 51 are provided. A horizontal rodless air cylinder 53 is supported on the cylinder support portion 52, and an air cylinder movable portion 54 is attached to the cylinder support portion 52 so as to be movable in the horizontal direction. A lift rodless air cylinder 55 is attached to the air cylinder movable portion 54, and a plate gripping portion 56 is attached to this. Thereby, the plate gripping part 56 can be moved up and down in the vertical direction, and can be moved horizontally between the delivery tables R1 from the take-out position of the microplate 95 of the supply and recovery apparatus shown in FIG.

  The plate gripping portion 56 is composed of a bifurcated round bar 59 and a plate-like plate 60, and a pair of clamping members that clamp both side surfaces of the microphone plate 95, and microscopically from both side surfaces opposite to the pair of clamping members. A pair of holding arms 63 for holding the bottom surface of the plate 95 is provided.

  The plate-like plate 60 constituting the pair of clamping members is provided with a protruding portion 61 at the bottom thereof that comes into contact with the side surface of the bottom surface protruding portion 97 of the microplate body. The protrusion 61 extends in the side surface direction of the microplate 95 by a predetermined length. The plate-like plate 60 and the bifurcated round bar 59 can be moved so as to be opened and closed by a clamping actuator 57, whereby the microplate 95 is clamped between the projection 61 of the plate-like plate 60 and the tip of the bifurcated round bar 59. .

  The clamping state will be described with reference to FIG. As described above, the linear protrusion 61 contacts the bottom protrusion 97 of the microplate body 96. On the other hand, the tip of the bifurcated round bar 59 is positioned slightly higher so that the tip of the double bar 59 comes into contact with the side surface of the lid portion 98 of the microplate 95. Therefore, as shown in FIG. 14, when the microplate 95 is sandwiched between the tip of the bifurcated round bar 59 and the protruding portion 61, the microplate lid 98 and the microplate body 96 are pressed against each other. Since it is nipped while being pushed obliquely, the lid 98 and the main body 96 are not separated when nipping and lifting. Thus, in order to pinch the bottom surface portion 97 and the lid portion 98 of the microplate body obliquely and accurately, the height adjustment of the plate gripping portion 56 is important, so the height sensor 65 is provided, The height of the plate gripper 56 is accurately adjusted by a plate detection signal from the height sensor.

  When sandwiched between the pair of sandwiching members and slightly lifted, the bottom surface of the microplate 95 is then retained by the pair of retaining arms 63. The pair of holding arms 63 can be opened and closed by a holding actuator 62. Each of the pair of holding arms 63 includes a claw 64 extending horizontally. The holding arm 63 is provided so that the claw 64 is at a height that supports the bottom surface of the microplate when the microplate 93 is accurately clamped, and the microplate 95 is slightly lifted by a pair of clamping members. By closing the pair of holding members 63, the bottom surface of the microplate 95 is securely held by the claws 64.

  The plate gripping part 56 that grips the microplate 95 by the pair of holding members and the pair of holding members 63 is lifted upward by the lifting rodless air cylinder 55. Thereafter, the horizontal rodless air cylinder 53 is moved horizontally from the supply storage unit 40 to the delivery table R1 or from the delivery table R1 to the supply storage unit 40. When moved to a predetermined position, the plate gripper 56 is lowered to a predetermined height by the lifting rodless air cylinder 55, and then the pair of holding arms 63 and the pair of clamping members are released, and the microplate 95 is moved. It is mounted on the uppermost stage of the cassette 40 of the delivery table R1 or the supply storage unit 40.

[Microplate cassette]
An example of the cassette for microplates used for the microplate supply and recovery apparatus of the present invention is shown in FIG. FIG. 15A shows a state where the microplate 95 is not housed, and FIG. 15B shows a state where the microplate 95 is housed. The microplate cassette 80 according to the present invention can store the microplates 95 in a stacked manner.

  The cassette 80 is composed of six metal pipes 83 arranged so as to connect the three sides of the upper frame 81 and the lower frame 82 between the cassette upper frame 81 and the cassette lower frame 82 each having only three sides of a substantially square shape. And a handle 85 is provided on the upper frame 81. Further, small doors 84 are provided on both sides of the opened side.

  A door claw 87 is provided at the tip of the hinge 87 at the lower part of the door. Further, a hole is made in the outer portion of the cassette lower frame 82 where the hinge 87 at the lower part of the door is closed, and the door lock pin 89 provided with stoppers 90 at the upper and lower ends is freely lowered by its own weight. Are fitted together.

  FIGS. 16A and 16B are partially enlarged side views showing the relationship between the door lock pin 89 and the stopper 90. FIG. When the cassette 80 is placed on a flat base, the door lock pin 89 is pushed up as shown in FIG. 16A, and the stopper 90 having an outer diameter larger than the axis of the door lock pin 89 is Also protrudes upwards. Since the shaft of the door lock pin 89 is thin, the door claw 88 can be freely opened and closed without engaging the shaft.

  On the other hand, when the cassette 80 is lifted, the pin 89 falls down as shown in FIG. Thus, during the opening / closing operation, the door claw 88 of the door lower portion 87 engages with the stopper 90 to prevent the door 84 from being opened. Further, a spring 90 is provided between the door lower portion 87 and the cassette lower frame 82, and the door 84 is biased in the closing direction.

  Thus, when the cassette 80 is placed on a flat table, the door 84 can be opened, and the microplate 95 can be freely inserted from the side surface of the release portion 94 and stacked. When the cassette 80 is lifted, the door lock pin 89 is lowered and the door 84 is closed and locked by the spring 92, so that the microplate does not fall toward the release portion 92.

  Further, the rotary storage base 43 on which the cassette 80 is set is provided with a retraction hole (not shown) for retracting the door lock pin 89 when the cassette is placed so that the door lock pin 89 is not released. be able to. As a result, the door 84 does not open while the cassette is stored in the rotary storage base 43, and the microcassette 95 can be prevented from falling from the release portion 94 side.

  A bottom surface opening 93 is provided on the bottom surface of the cassette 80, and a side surface opening 92 similar to the bottom surface opening 93 exists even when the small door 84 is closed. Further, an upper surface opening 94 is provided on the upper surface of the cassette so that the microplate 95 can be taken in and out. Thereby, the lift piece 46 of the plate raising / lowering part 45 can be raised upward via the bottom surface 94 and the side surface opening 92, and the microplate 95 can be taken out from the top surface opening 94 or stored in the cassette.

  The supply / recovery unit 40 according to the present invention takes out or collects the microplate from the upper side of the cassette 80. Therefore, the cassette can be set on the rotary storage base 43 only by placing the cassette 80 on the rotary storage base 43 provided at a low position that is slightly lifted from the floor. Thus, it is not necessary to set the microplates 95 one by one in the supply / recovery device 40, and the supply / recovery device 40 can be replenished with the microcassettes 95 simply by setting the cassettes in units of 80 cassettes. In addition, since it is not necessary to lift a heavy cassette to a high position, it is only necessary to lift the cassette 80 slightly and place it on the rotary storage base 43, so that the microplate can be replenished with a much lighter work than before. Became possible.

[Dispensing processing equipment]
Hereinafter, the dispensing process will be briefly described. The microplate main body portion 96 with the lid portion 98 removed and placed on the delivery table R2 is lifted by the pickup portion (second pickup portion) of the dispensing device 70 and placed on the dispensing stand 75. A pick-up device (not shown) is provided at the tip of a dispensing head 74 that can move in the X-axis, Y-axis, and Z-axis directions, lifts the microplate body of the delivery table R2, and moves to the dispensing table 75. To do.

  The dispensing head 74 is attached to the lower part of the movable member 73. The movable member 73 is movable in the vertical direction (Z-axis direction) and the direction crossing the conveyance path (Y-axis direction) on two movable frames 71 movable in the vertical direction (X-axis direction) along the conveyance path. Is provided. Thereby, the dispensing head 74 is movable in all directions of the X axis, the Y axis, and the Z axis.

  Dispensing pipettes (not shown) of the number corresponding to the wells 99 of the microplate are provided at the tip of the dispensing head 74, and after sucking up the chemical solution from the chemical solution tank 77 with the pipette, Dispense into well 99 of microplate 95. Before sucking up the chemical solution, the pipette tip of the dispensing head 74 is inserted into the pipette cassette 76, and a disposable pipette tip (not shown) is attached to the tip of the pipette. The pipette tip is automatically removed from the pipette tip after the dispensing process is completed and discarded.

  The microplate 95 for which the dispensing process has been completed is lifted by a pickup device provided at the tip of the dispensing head 75 and returned to the delivery table R2 or R3. The microplate 95 returned to the delivery table R2 or R3 is lifted by the transport table 12 of the shuttle transport unit 11 and transported to the delivery table R1 or R4, as described above. The microplate 95 transported to the delivery table R2 is returned to the supply / recovery device 40 by the pickup device 50, and the microplate transported to the delivery table R4 is moved to the shelf 120 and the analysis device 130 by the horizontal rotation type feeding robot 110. Then, it is conveyed to the moisturizing device 140.

[Horizontal rotating robot and other peripheral devices]
FIG. 17 is a plan view showing a state of conveyance of the microplate 95 by the horizontal rotation type robot 110. In this embodiment, a transfer robot RR701 manufactured by Lhotse Co., Ltd. is used as the horizontal rotation type robot 110. The horizontal rotation type robot 110 has two arm bodies each composed of a first arm 111, a second arm 112, and a finger 113, each rotating in a horizontal plane, and the two fingers 113 are overlapped with each other with a difference in height. The body 115 linearly moves in a vertical plane, and the body 115 has a X-axis trajectory that moves the entire horizontal rotation type robot 110 at right angles to the shuttle type transfer lines La to Lc. doing. However, the finger 113 is a rectangle that is long in the direction of travel with six plastic bell-shaped projections 8 mm in height and 6 mm in diameter around it, and the microplate 95 placed here does not fall, and the delivery table R4 and It has a structure that does not interfere. This horizontal rotation type robot 110 is inserted on the finger 113 so that the finger 113 is inserted under the delivery table R4 on which the microplate 95 is placed, and the body 115 is lifted in the Z-axis direction to scoop up the microplate 95. Put. When transporting and arriving above the target transport base, the body 115 is lowered in the Z-axis direction, and the microplate 95 is placed on the target location from the finger 113. Here, the destination places are the shelf 120, the analyzer sample inlet / outlet 131, the incubator sample inlet / outlet 141, and each stage 48.

  The horizontal rotation type robot 110 places the drug-containing microplate 95 sent by the shuttle type transfer device 10 on one finger 113 so as to scoop up from below, and turns to move toward the warmer 140. . The sample microplate 95 that has exited from the incubator sample inlet / outlet port 141 after being processed for a predetermined time is placed on the other finger 113 and removed, and a new sample microplate 95 that has been carried is inserted instead. The incubator (Cytomat 6000) automatically processes the sample at a constant temperature for a predetermined time even if the sample is automatically loaded one box at a time. Next, it turns and goes to the direction of the sample inlet / outlet 131 of the analyzer (1430 ViewLux I / F), the vacant finger 113 is extended to take out the analyzed sample microplate 95, and the processed sample microplate 95 taken out from the incubator is removed. Insert. Since the microplate lid 192 has to be removed for analysis, the analyzer sample inlet / outlet 131 is also provided with a lid adsorber 28. The analyzed sample microplate 95 taken out is placed on the delivery table R4 of the shuttle type transport paths La to Lc. The sample microplate 95 before processing waits in the order of the incubator 140 or when the delivery from the incubator 140 and the timing to the analyzer 130 do not match, temporarily store them on the shelf 120 and wait for the order. Be analyzed.

  Fig.12 (a) is a top view which shows the structure of the storage shelf 120 of this invention. FIG. 12B is a cross-sectional view taken along the line BB ′ in FIG. Between the bottom plate 124 and the top plate 123, a plurality of thin inner columns (columns) 121 and a plurality of thick outer columns (columns) 122 are arranged in concentric arcs. The shape of each column is the same as the inside and outside of the shelf. The column part 125, the trapezoidal part 126, and the collar part 127 are connected from the top, and the outer edge corner of the bottom of the microplate 95 is connected to the upper surface of the collar part 127. Appears. Therefore, the dimension between the lower part of the trapezoidal part 126 of the two inner pillars 121 and the lower part of the trapezoidal part 126 of the two outer pillars 122 are the same and slightly longer than the width of the microplate 95, The center-to-center dimension between the inner column 121 and the outer column 122 is designed to be slightly shorter than the length of the microplate 95, and one microplate 95 is placed there. A box stopper 128 for preventing the microplate 95 from penetrating and falling is provided on the outer side of the outer column 122.

  Thus, in the storage shelf 120, a plurality of protrusions are provided in the middle part of the columns 121 and 122, and the microplate is supported by the protrusions between the columns. Therefore, the microplate 95 stored in the storage shelf 120 can be easily taken out by scooping up the robot fins 113. Therefore, control is simpler than picking out the side surfaces, and the microplate can be picked up quickly and accurately.

  Moreover, the storage shelf 120 can be assembled only by providing a protrusion in the middle of the column and connecting the top plate and the bottom plate by this column. Therefore, the number of parts is small and assembly is easy. Moreover, since the protrusion is integrally formed on the support column, it is possible to easily create a storage shelf with higher accuracy than assembly.

  The microplate 95 is inserted between the column portions 125 of the two inner columns 121 of the storage shelf 120 of FIG. 12 to the vicinity of the outer columns 122 while being placed on the fingers 113 of the horizontal rotation type robot 110. , The outer edge corners of the four bottoms of the microplate 95 are placed on the collar 127. On the contrary, when taking out the microplate 95, the empty finger 113 is inserted between the two cylindrical portions 125 and stopped so that the six plastic bell-shaped projections are below the outer edge of the microplate 95. Next, it is raised and placed, and a finger is pulled on the robot 110 side. Next, the robot 110 conveys the microplate 95 to the destination.

[About microplate transport control]
Each drive part of the shuttle type | mold conveying apparatus 10, the supply collection | recovery apparatus 40, and the pick-up apparatus 50 is controlled by the control part. FIG. 19 shows a basic functional block diagram of the control device 150. The control device 150 is a computer that includes a central processing unit (CPU), a control program, a storage unit for storing and storing control programs, control data, and the like, and a logic circuit. Various operations are sequentially executed in accordance with control commands from the control. In various operations, feedback signals from various sensors (not shown) arranged in the conveyance path, shuttle conveyance unit, and other units are referred to.

  The control device 150 includes a control unit 151, communicates with a system control unit that controls the operation of the entire analysis processing system via a communication interface (not shown), and in accordance with instructions from the system control unit, the shuttle transport unit 11 The various operations of the supply / recovery unit 40 and the pickup unit 50 are controlled. In addition to the control unit 151, the control device 150 includes a take-out control unit 152, a transport control unit 153, a delivery control unit 154, a supply / recovery control unit 155, and a pickup control unit 156.

  The take-out control unit 152 controls the shuttle motor 15 and the transport table motor 17 under the control of the control unit 151 to lift and take out the microplates (conveyed objects) on the delivery tables R1 to R4. The transport unit 11 is controlled. The conveyance control unit 153 controls the shuttle motor 15 and the conveyance table motor 17 under the control of the control unit 151 to convey the shuttle conveyance unit 11 that conveys the taken-out object to be delivered to the target delivery tables R1 to R4. Control. Under the control of the control unit 151, the delivery control unit 154 controls the shuttle motor 15 and the conveyance table motor 17 to transfer the object to be conveyed on the conveyance table unit onto the transfer tables R1 to R4 as transfer destinations. The shuttle transport unit 11 is controlled to be placed.

  The supply / recovery control unit 155 controls the drive of the rotation drive motor 43b that rotates the rotation storage base 43, and controls to rotate the microplate to be taken out to the front of the plate lifting / lowering unit. When the microplate 95 is sent out from the cassette 80, the lift piece 46 is lifted by one microcassette, and when the microcassette 95 is collected, the lift piece 46 is lowered by one.

  The pickup control unit 156 controls the sandwiching actuator 57 and the holding actuator 62 of the pickup device 56 under the control of the control unit 151 to sandwich the side surface of the microplate 95 with the pair of sandwiching arms 59 and 60. , Hold and lift with a pair of holding arms 63.

[Conveying process flowchart]
With reference to FIG. 20, an example of a conveyance processing procedure for the object to be conveyed will be described. FIG. 20 is a flowchart showing a conveyance control processing procedure of an object to be conveyed by the shuttle type conveyance device of the present invention. In the flowchart, confirmation of completion of lifting and lowering of the transport table and confirmation of various transport positions are performed. These confirmations can be confirmed by the driving time of each driving unit and a feedback signal, but it is preferable that various sensors are provided in each part of the conveyance path, the shuttle conveyance unit, and the like and confirmed by the sensor signal. The control unit 151 confirms whether or not a transport command has been received. When the transport command is received (S101; Yes), the control unit 151 confirms whether or not the shuttle transport unit 11 is in operation (S102). If the shuttle transport unit 11 is not operating (S102; No), the transport platform 12 of the shuttle transport unit is lowered (S103). When the lowering of the transport table 12 is completed (S104; Yes), the shuttle transport unit 11 is moved to the delivery tables R1 to R4 on which the objects to be transported are placed (S105).

  When the shuttle transport unit 11 moves to a position just below the target delivery table (S106; Yes), the transport table unit 12 is raised and the transported object unit is lifted by the transport table unit 12 from below the delivery table (S107). When the lifting of the transport table 12 is completed (S108), the shuttle transport unit 11 is moved to the outside of the delivery table while lifting the transported object (S109). When the movement is completed (S110; Yes), the transported object is moved. The transport table 12 is lowered while being placed (S111). At this time, the control unit 151 determines whether or not there is an obstacle up to the transfer destination, such as the transfer destination adjacent to the transfer destination, and when there is no obstacle, skips steps S111 and S112. It is possible.

  When the lowering of the transport table 12 is completed (S112; Yes), the shuttle transport unit 11 starts to move (S113). The shuttle transport unit 11 moves under the delivery table while the object to be transported is placed on the transport table 12. When the shuttle transport unit 11 moves to the next to the delivery table that is the designated transport destination (S114; Yes), the transport table unit 12 is raised (S115). When the raising of the transport table 12 is completed (S116; Yes), the shuttle transport unit 11 is moved to a position directly above the delivery table (S117). When the movement is completed (S118; Yes), the operation base 12 is passed through the bottom opening 23 and lowered to the bottom of the delivery base (S119). When the lowering of the operation console unit 12 is completed, the transfer process is terminated and the next transfer command is awaited.

  In the above description, only the example of transporting the microplate is described as the transported object to be transported by the shuttle type transport apparatus. However, the transported object that can be transported by the shuttle type transport apparatus according to the present invention is the same. Is an example, and is not limited to a microplate, and has a certain width, can be placed on the transfer table of the present invention, and can be placed on the transfer table of the shuttle transfer unit. Can be transported.

  When an object other than the microcassette is conveyed, the structure of the conveying table unit 12, the lifting device, and the structure of the driving device can be appropriately changed by known techniques according to the weight of the object to be conveyed. For example, if the weight is heavy, it can be lifted using a hydraulically driven piston. In addition, the raising / lowering apparatus which raises / lowers a conveyance stand part should just take two positions, a high position and a low position. The high position is a position where the conveyance table 12 lifts the object to be conveyed such as the microplate 95 on the delivery tables R1 to R4, and the low position holds the object to be conveyed at a position lower than the delivery tables R1 to R4. And it is a position which travels under delivery stand R1-R4.

  In addition, as a driving means for moving the shuttle transport unit 11 in the transport paths La, Lb, and Lc, it is possible to use well-known conventional techniques that can be used by those skilled in the art, such as stepping motors, linear motors, and ultrasonic motors.

DESCRIPTION OF SYMBOLS 1 Analysis processing system 10 Shuttle type conveyance apparatus 11 Shuttle conveyance part 12 Conveyance stand part 13 Linear guide 14 Gear 15 Shuttle motor 16 Roller 17 Air cylinder 18 Lifting rod 20 Strut part 21 Support plate 22 Positioning pin 25 Base 27 Timing belt 28 Lid Suction machine 29 Belt fixing part 30 Lifting rodless cylinder 40 Microplate supply and recovery device 41 Storage part frame 42 Base part 43 Storage base 43a Positioning pin 44 Lift piece opening 45 Plate lift part 46 Lift piece 50 Pickup device
57 Actuating actuator 56 Plate gripping part 59 Forked round bar 60 Plate-like plate 61 Projection part 62 Holding actuator 63 Holding member 70 Dispensing processing device 75 Dispensing stage (dispensing stand)
80 Microplate cassette 84 Door 89 Door lock pin 90 Stopper 95 Microplate 96 Microplate main body 97 Bottom surface 98 Cover 99 Well
110 Horizontally-rotating transfer robot 120 Storage shelf 121 Thin support column 122 Thick support column 123 Top plate 124 Bottom plate 130 Analyzer 140 Moisturizers La to Lc Shuttle type transfer paths R1 to R4

Claims (12)

A pickup device comprising a main body part and a lid part, and picking up and picking up a rectangular microplate capable of sandwiching each of the main body part and the lid part from the side surface,
A pair of sandwiching arms for sandwiching the microplate from the right and left by abutting the body with one sandwiching arm and the lid with the other sandwiching arm when sandwiching and sandwiching the side surface of the microplate; ,
An opening / closing drive unit for opening / closing the pair of sandwiching arms;
An elevating drive unit for elevating the pair of sandwiching arms in the vertical direction;
A pickup control unit for controlling the operation of the opening / closing drive unit and the elevation drive unit;
A pick-up device for a microplate, comprising: 2. The microplate pickup device according to claim 1 , wherein the pair of sandwiching arms sandwich the main body portion and the lid portion obliquely at different left and right heights. The microplate pickup device according to claim 1 , further comprising a detection sensor for detecting a height position of the microplate to be sandwiched. 2. The microplate pickup device according to claim 1 , further comprising a pair of holding members that hold a bottom surface of the microplate from a side surface that is orthogonal to the pair of sandwiching members. The pickup control unit, after slightly lifting the microplate by holding portions of said pair to claim 4, wherein the controller controls to hold the bottom surface of the microplate by the holding member of the pair The pick-up apparatus for microplates as described. One elevating part provided with a lift member for lifting the laminated microplate from the bottom;
A cassette storage base having an opening through which the lift member can pass on the bottom surface, an opening through which the microplate can pass through the top surface, and a cassette for stacking and storing the microplates;
A pick-up device for a microplate according to any one of claims 1 to 5,
With
A microplate supply / recovery device , wherein the microplate stacked on the lift member is held by the microplate pickup device. The microplate supply / recovery device according to claim 6 , wherein the cassette storage table is capable of mounting a plurality of cassettes. The elevating part is arranged at a position inscribed inside the cassette storage base, and is configured such that each of the attached cassettes comes into contact with the front of the elevating part as the cassette storage base rotates. The microplate supply / recovery device according to claim 7 , wherein The microplate supply / recovery device according to claim 8 , wherein the elevating member is provided at a central portion of the cassette storage base. The cassette is
A side support frame that supports the side of the microplate from three directions;
A bottom support frame having an opening smaller than the microplate;
An upper surface support frame having an opening larger than the microplate;
A short door portion to support the microplate from the remaining one direction of the side support frame,
The microplate supply / recovery device according to claim 6, comprising: The cassette is
The bottom support frame part is lowered by gravity when lifted, protrudes from the lower side and locks the door part in a closed state, and unlocks the door by lifting upwards, The microplate supply and recovery device according to claim 10, further comprising an elastic member that biases the door in a closing direction. The cassette is
12. The microplate supply / recovery device according to claim 11 , wherein the side support frame includes a plurality of support rods connecting the upper surface support frame portion and the bottom surface support frame portion.

Images