WO2016203983A1 - Dispositif endoscopique - Google Patents

Dispositif endoscopique Download PDF

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Publication number
WO2016203983A1
WO2016203983A1 PCT/JP2016/066541 JP2016066541W WO2016203983A1 WO 2016203983 A1 WO2016203983 A1 WO 2016203983A1 JP 2016066541 W JP2016066541 W JP 2016066541W WO 2016203983 A1 WO2016203983 A1 WO 2016203983A1
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WO
WIPO (PCT)
Prior art keywords
light
image
narrowband
generation unit
generated
Prior art date
Application number
PCT/JP2016/066541
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English (en)
Japanese (ja)
Inventor
伊藤　光一郎
Original Assignee
オリンパス株式会社
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Publication of WO2016203983A1 publication Critical patent/WO2016203983A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
    • A61B1/0655—Control therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances

Definitions

  • the present invention relates to an endoscope apparatus.
  • an endoscope system that has a light emission mechanism that emits special light having different spectral characteristics between normal illumination and normal illumination light (for example, Patent Document 1).
  • the normal illumination light emitted from the light source is transmitted through a filter having spectral characteristics that are inclined upward or downward toward the long wavelength side with respect to the wavelength axis.
  • Special light is generated and a spectral image is generated. That is, for normal illumination light, by shifting the peak of spectral characteristics using a filter, special light is generated by artificially splitting one wavelength band into two narrow wavelength bands. Is generated.
  • Patent Literature 2 as a technique for acquiring an image by spectrally dividing light in a narrow wavelength band, the light color is switched to at least one of four colors, and the light irradiation direction on the object is switched to perform light.
  • An optical characteristic measuring apparatus and an image processing system for acquiring an image by selecting a wavelength by irradiating the light are disclosed.
  • JP 2008-23101 A Japanese Patent No. 4806638
  • the optical characteristic measuring apparatus of Patent Document 2 has many switching of irradiation direction and wavelength selection when acquiring a spectral image, and is not suitable for imaging a moving object.
  • the present invention has been made in view of the above-described circumstances, and an object thereof is to provide an endoscope apparatus capable of acquiring a highly accurate spectral image.
  • an illumination unit that irradiates a living tissue with illumination light including light of each region with respect to R, G, and B, and at least two wavelength bands of R, G, and B that constitute the illumination light.
  • a narrowband light generating unit that generates 2 narrowband light having an intensity ratio of 1: 2 or more, and the narrowband light generated by the narrowband light generating unit and the reflection of the illumination light in the living tissue
  • An endoscope apparatus including an imaging unit that acquires an image signal based on light and an image generation unit that generates an image based on the image signal acquired by the imaging unit.
  • the narrowband light is generated by the narrowband light generation unit from the light of at least two wavelength bands of R, G, and B of the illumination light emitted from the illumination unit, and these narrowband lights are generated.
  • the imaging unit Is irradiated onto the living tissue, and the reflected light of the narrow band light in the living tissue is photographed by the imaging unit to obtain a plurality of image signals. That is, the image signal obtained by capturing the reflected light of a total of 5 or more wavelength bands, that is, the reflected light of at least four narrow-band lights generated by the narrow-band light generation unit and the reflected light of illumination light, respectively, by the imaging unit. Based on the above, an image is generated by the image generation unit.
  • Each of the two narrow-band lights generated by the narrow-band light generation unit is narrow-band light that is split from at least two wavelength bands of R, G, and B, and the intensity ratio is 1: 2 or more, respectively. . For this reason, a sufficient difference is obtained between the image signals acquired based on the reflected light by the narrow band light, and a highly accurate image signal can be acquired. Then, by synthesizing the image signals obtained in this way, it is possible to obtain a high-quality image in which light in each wavelength band of R, G, or B is reproduced in a balanced manner.
  • the image generation unit is acquired from reflected light of at least one narrowband light belonging to each of the R, G, and B wavelength bands among the narrowband light generated by the narrowband light generation unit.
  • a white light image may be generated based on the image signal.
  • generation part is obtained.
  • a combined white light image is generated. That is, the appearance of the living tissue can be observed with a white light image having a color reproduction similar to that obtained when white light is illuminated.
  • a white light image based on an image signal acquired from reflected light of all narrow band light generated by the narrow band light generation unit.
  • a white light image is generated by combining the image signals acquired from the reflected light of the all narrow band light generated by the narrow band light generation unit, and color reproduction close to the image obtained during white light illumination The appearance of the living tissue can be observed from the white light image.
  • the special light image can be generated based on the image signal acquired from the reflected light of any two or three of the narrowband lights generated by the narrowband light generator. .
  • a special light image that can observe a specific observation target component with high contrast is generated by combining image signals acquired by photographing reflected light from some narrowband light, A desired observation target component can be observed with the special light image.
  • the image generation unit is acquired from reflected light of at least one narrowband light belonging to each of the R, G, and B wavelength bands among the narrowband light generated by the narrowband light generation unit.
  • a white light image is generated based on the image signal, and based on the image signal acquired from the reflected light of any two or three of the narrow band lights generated by the narrow band light generation unit.
  • a special light image that can observe a specific observation target component with high contrast is generated by combining image signals acquired by photographing a part of reflected light in a narrow band, and narrow.
  • a white light image is generated by combining image signals acquired by photographing all the narrowband reflected light generated by the band light generation unit.
  • a plurality of generated images are displayed on the display unit at the same time, so that the appearance of the living tissue is always observed with a white light image with a color reproduction similar to that obtained with white light illumination, and the observation target component by the special light image It is good also as performing observation of.
  • FIG. 1 is an overall configuration diagram showing an endoscope apparatus according to an embodiment of the present invention. It is a figure which shows the transmittance
  • the endoscope apparatus includes an insertion unit 2 that is inserted into a living body, a light source unit 3 that is connected to the insertion unit 2, and a processor unit that is connected to the insertion unit 2. 4 and a monitor (display unit) 5 for displaying an image generated by the processor unit 4.
  • the insertion unit 2 includes an illumination optical system 21 that irradiates light input from the light source unit 3 toward the subject, and an imaging optical system (imaging unit) 22 that captures reflected light from the subject.
  • the illumination optical system 21 is arranged over the entire length of the insertion portion 2, and is guided by the light guide cable 23 that guides light incident from the light source portion 3 on the proximal end side to the distal end 2 a, and the light guide cable 23.
  • a diffusion optical system 24 that irradiates light forward from the distal end 2a of the insertion portion 2. That is, the light source unit 3 and the illumination optical system 21 constitute an illumination unit.
  • the imaging optical system 22 includes a lens 26 that forms an image on reflected light of the light irradiated by the illumination optical system 21 on the imaging element 25 and an imaging element 25 that captures the light collected by the lens 26.
  • the imaging element 25 is a color CCD provided with a filter that transmits blue, green, and red light to each pixel.
  • the image signal acquired by the image sensor 25 is converted into a digital signal by an A / D converter (not shown).
  • the light source unit 3 includes two sets of narrow bands from a xenon lamp 31 that generates white light and R, G, and B wavelength bands that form white light emitted from the xenon lamp 31.
  • a filter turret 32 having three spectral filters F1, F2, and F3 that cut out light, a condensing lens 33 that makes narrowband light cut out by the filter turret 32 incident on the light guide cable 23, a xenon lamp 31, and a filter And a light source control unit 34 for controlling the turret 32.
  • the three spectral filters F1, F2, and F3 are two-band filters each having two transmission wavelength bands.
  • the first spectral filter F1 has a transmission wavelength band of B1 (400 nm to 450 nm) and R2 (610 nm to 700 nm).
  • the second spectral filter F2 has a transmission wavelength band of G2 (530 nm to 610 nm) and R1 (560 nm to 610 nm).
  • the third spectral filter F3 has a transmission wavelength band of B2 (450 nm to 500 nm) and G1 (490 nm to 530 nm).
  • the broken line indicates the sensitivity of the color CCD 12.
  • the spectral filters F1, F2, and F3 are arranged on the optical path, the wavelength characteristics of the light imaged in the R, G, and B pixels of the color CCD 12 are different.
  • An image signal having different wavelength components can be obtained by combining three types of spectral filters F1, F2, and F3 and R, G, and B. That is, the narrow-band light generating unit that generates two narrow-band lights from at least two of the R, G, and B wavelength bands constituting the illumination light by the three spectral filters F1, F2, and F3. Is configured.
  • the light source control unit 34 controls the xenon lamp 31 and the filter turret 32 according to a control signal from the control unit 43 of the processor unit 4 described later.
  • the ratio of the intensity of the adjacent narrowband light to the intensity of the narrowband light is 50% or less.
  • the spectral filter has a steep spectral characteristic as shown in FIGS. 2A to 2C because a highly accurate spectral image can be obtained.
  • the wavelength region to be cut may have an inclination without becoming steep. That is, a spectral filter having steep spectral characteristics can obtain an image having spectral information as shown by a triangle T1 formed in the vicinity of a wavelength of 400 nm to 450 nm in FIG. 3B, whereas FIG. In the case of a spectral filter exhibiting such spectral characteristics, unnecessary information such as a triangle T2 formed in the vicinity of a wavelength of 450 nm to 470 nm in FIG. 3B is also included at the same time.
  • an image with a desired accuracy can be acquired. That is, if the intensity ratio of the two narrowband lights generated by the narrowband light generator is 1: 2 or more, an image with a desired accuracy can be acquired.
  • the blood vessel image should appear black due to absorption.
  • the contrast is lowered. If the ratio of the area of the triangle T2 to the area of the triangle T1 is 1: 2 or more, an image having necessary spectral information can be acquired without reducing the contrast.
  • the processor unit 4 processes the image signal stored in the memory 41 and the memory 41 that stores the image signal acquired by the image sensor 12 in association with the wavelength band of the narrowband light corresponding to the acquired image signal.
  • the image processing unit 42 generates a white light image and a special light image by combining image signals corresponding to each wavelength band stored in the memory 41.
  • the white light image can be generated by synthesizing all the image signals corresponding to the narrowband light of R1, R2, G1, G2, B1, and B2, and for each of R, B, and G, It can be generated by synthesizing at least one of the narrowband lights.
  • the special light image can be generated by synthesizing any two or three of the image signals corresponding to the narrowband light of R1, R2, G1, G2, B1, and B2.
  • the control unit 43 synchronizes the rotation of the filter turret 32 of the light source unit 3 and the photographing by the image sensor 25, stores the image signal acquired by the image sensor 25 in the memory 41, and reads it from the memory 41. Based on the image signal, the image processing unit 43 is controlled to generate any of the above images.
  • white light emitted from the xenon lamp 31 passes through one of the spectral filters F1, F2, and F3 arranged on the optical path by the rotation of the filter turret 32.
  • the spectral filters F1, F2, and F3 arranged on the optical path by the rotation of the filter turret 32.
  • two sets of narrowband light are cut out for each of the wavelength bands of R, G, and B, collected by the condenser lens 33, and incident on the incident end of the light guide cable 23.
  • Illumination light guided to the distal end 2 a of the insertion portion 2 by the light guide cable 23 is irradiated to the biological tissue disposed to face the distal end surface of the insertion portion 2, and reflected light from the biological tissue is imaged by the lens 26.
  • the image is picked up by the image pickup device 25.
  • the image sensor 25 is provided with a filter that transmits light in each wavelength band of R, G, and B for each pixel, and is included in each wavelength band of R, G, and B in the reflected light in the living tissue.
  • the reflected light in the wavelength band is photographed by the corresponding pixel.
  • a white light image composed of an image signal acquired from one narrow band light and a special light image composed of the selected image signal are generated and displayed on the monitor 5.
  • a white light image and a desired special light image are obtained by switching and arranging the three types of filters F1, F2, and F3 on the optical path.
  • Can do That is, it is not necessary to prepare as many filters as the number of images to be observed, and it is possible to easily acquire image signals for many wavelength bands and acquire high-accuracy images.
  • the white light image and the special light image can be displayed on the monitor 5 at the same time or can be switched appropriately, the state of the living tissue can be confirmed in the white light image having a color reproduction close to the image obtained at the time of the white light illumination.
  • the configuration in which the light source unit 3 includes the xenon lamp 31 and the three spectral filters F1, F2, and F3 has been described.
  • the configuration of the light source unit 3 is not limited to this, and various configurations are used. Can do.
  • an example of the light source unit will be described as a modification. In the following modifications, the same reference numerals are given to the same configurations as those of the endoscope apparatus according to the above-described embodiment, and the description thereof is omitted.
  • the light source unit according to the modified example 1 uses a xenon lamp or a halogen lamp as a light source, and the filter turret includes two spectral filters each having three bands (in the following description, a fourth spectral filter F4 and a fifth spectral filter).
  • the filter F5 may be provided (see FIG. 4).
  • the fourth spectral filter F4 has transmission wavelength bands of B2 (400 nm to 450 nm), G1 (490 nm to 530 nm), and R2 (610 nm to 700 nm).
  • the fifth spectral filter F5 has transmission wavelength bands of B1 (400 nm to 450 nm), G2 (530 nm to 610 nm), and R1 (560 nm to 610 nm).
  • the broken line indicates the sensitivity of the color CCD 12.
  • the fourth spectral filter F4 and the fifth spectral filter F5 are three-band filters each having three transmission wavelength bands.
  • the spectral filters F4 and F5 are arranged on the optical path, the wavelength characteristics of light photographed in the R, G, and B pixels of the color CCD 12 are different.
  • An image signal having different wavelength components can be obtained by combining the three types of spectral filters F4 and F5 and the three types of pixels R, G, and B. That is, the two spectral filters F4 and F5 constitute a narrowband light generating section that generates two narrowband lights from the R, G, and B wavelength bands that constitute the illumination light.
  • the xenon lamp 31 is exemplified as the light source, but other white light sources such as a halogen lamp, a mercury lamp, and a white LED can be used instead.
  • the light source unit 3 generates narrowband light by the xenon lamp 31 and the filter turret 32. Instead of this, the light source unit 3 has a six-color LED (illumination). Part and a narrow band generation part).
  • the first to sixth LEDs emit light corresponding to the wavelength bands B1, B2, G1, G2, R1, and R2, respectively. Yes.
  • the broken line indicates the sensitivity of the color CCD 12.
  • each LED it is possible to obtain an image signal based on narrowband light belonging to a total of six wavelength bands by combining and alternately lighting three LEDs that emit light in wavelength bands belonging to different colors. . That is, as shown in FIG. 7A, LEDs that emit B1, R1, and G1 lights are turned on at the first timing, and B2, R2, and G2 lights are emitted at the second timing as shown in FIG. 7B.
  • the LED to be turned on may be turned on. In this way, six types of image signals having different wavelength components can be obtained.
  • the light source unit 3 may be configured to include a five-color LED and two spectral filters.
  • one of the five LEDs emits light including all of the G wavelength band, and the remaining four LEDs have wavelength bands of B1, B2, R1, and R2, respectively.
  • the light corresponding to is emitted.
  • the two spectral filters a long wavelength cut filter near 540 nm and a short wavelength cut filter are applied.
  • the LEDs that emit B1 and G light are turned on at the first timing, and a long wavelength cut filter is applied, and as shown in FIG. 9B, R2 and G are turned on at the second timing. A light emitting LED is turned on and a short wavelength cut filter is applied. As shown in FIG. 9C, the LEDs emitting B2 and R1 light are turned on at the third timing. In this way, six types of image signals having different wavelength components can be obtained.
  • the light source unit 3 may be configured to include a two-color LED and two spectral filters.
  • the two LEDs are a V-LED and a white LED, and a spectral filter that does not transmit only near 530 to 610 nm and a filter that transmits only near 530 to 610 nm are applied. To do.
  • Imaging optical system Imaging unit
  • Image processing unit image generation unit
  • F1, F2, F3 spectral filters narrowband light generator

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Optics & Photonics (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endoscopes (AREA)
  • Instruments For Viewing The Inside Of Hollow Bodies (AREA)

Abstract

La présente invention acquiert une image spectrale de haute précision. La présente invention concerne un endoscope pourvu : d'une unité d'éclairage (3) pour irradier la lumière d'éclairage contenant de la lumière à partir des régions R, G et B sur tissu biomédical; d'unités de génération de lumière à bande étroite (F1, F2, F3) pour générer deux lumières à bande étroite ayant un rapport d'intensité de 1 : 2 ou plus pour au moins chacune de deux bandes de longueur d'onde parmi R, G et B constituant la lumière d'éclairage; d'une unité d'imagerie (25) pour acquérir chaque signal d'image sur la base de la lumière à bande étroite générée par l'unité de génération à bande étroite et la lumière d'éclairage réfléchie dans le tissu biomédical; et d'une unité de génération d'image (42) pour générer une image sur la base des signaux d'image acquis par l'unité d'imagerie.
PCT/JP2016/066541 2015-06-17 2016-06-03 Dispositif endoscopique WO2016203983A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2015121875A JP2018126174A (ja) 2015-06-17 2015-06-17 内視鏡装置
JP2015-121875 2015-06-17

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WO2016203983A1 true WO2016203983A1 (fr) 2016-12-22

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021181484A1 (fr) * 2020-03-09 2021-09-16 オリンパス株式会社 Dispositif de traitement d'image médicale, dispositif d'imagerie médicale, système d'observation médicale, méthode de traitement d'image et programme

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06237892A (ja) * 1993-02-17 1994-08-30 Olympus Optical Co Ltd 立体視内視鏡装置
JP2006341078A (ja) * 2005-05-12 2006-12-21 Olympus Medical Systems Corp 生体観測装置
JP2008283692A (ja) * 2002-07-26 2008-11-20 Olympus Corp 撮影装置、画像処理システム
JP2009131617A (ja) * 2007-11-09 2009-06-18 Fujifilm Corp 撮像システム、撮像方法、およびプログラム
JP2013521900A (ja) * 2010-03-17 2013-06-13 ズオン、ハイシャン 高速マルチスペクトルイメージングの方法および装置と癌検出および局在診断への応用

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06237892A (ja) * 1993-02-17 1994-08-30 Olympus Optical Co Ltd 立体視内視鏡装置
JP2008283692A (ja) * 2002-07-26 2008-11-20 Olympus Corp 撮影装置、画像処理システム
JP2006341078A (ja) * 2005-05-12 2006-12-21 Olympus Medical Systems Corp 生体観測装置
JP2009131617A (ja) * 2007-11-09 2009-06-18 Fujifilm Corp 撮像システム、撮像方法、およびプログラム
JP2013521900A (ja) * 2010-03-17 2013-06-13 ズオン、ハイシャン 高速マルチスペクトルイメージングの方法および装置と癌検出および局在診断への応用

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