WO2016202184A1 - 母猪产后配合饲料及其制备方法 - Google Patents

母猪产后配合饲料及其制备方法 Download PDF

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WO2016202184A1
WO2016202184A1 PCT/CN2016/084894 CN2016084894W WO2016202184A1 WO 2016202184 A1 WO2016202184 A1 WO 2016202184A1 CN 2016084894 W CN2016084894 W CN 2016084894W WO 2016202184 A1 WO2016202184 A1 WO 2016202184A1
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weight
parts
root
chinese medicine
powder
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PCT/CN2016/084894
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张建国
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张建国
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K50/00Feeding-stuffs specially adapted for particular animals
    • A23K50/30Feeding-stuffs specially adapted for particular animals for swines

Definitions

  • the invention relates to animal feed, in particular to a sow postpartum compound feed and a preparation method thereof.
  • a large number of bacteria in the reproductive tract of the sow including aerobic bacteria, anaerobic bacteria, fungi, chlamydia and mycoplasma, are mainly anaerobic bacteria.
  • Common pathogens are: aerobic streptococcus, anaerobic Gram-positive cocci, Escherichia coli, Staphylococcus, Bacteroides, Clostridium anatipum, Chlamydia, Mycoplasma and Neisseria gonorrhoeae.
  • Many non-pathogenic bacteria can cause disease in certain environments.
  • Postpartum fever in sows is caused by local or systemic inflammatory changes in the postpartum period when the pathogenic bacteria invade the genital tract before, during or after childbirth.
  • acute endometritis is the most common, and severe cases can develop acute para-uterine tissue inflammation, pelvic peritonitis, thrombophlebitis, and even sepsis, toxic shock and life-threatening.
  • Postpartum fever in sows is a common disease in postpartum sows. It is often 1-7 days after delivery of sows. It is characterized by fever, loss of appetite or abolition of sows. The temperature of sows rises to about 41 °C, and the spirit is depressed. Can not afford, chills, purulent secretion in the vagina, lactation reduced or stopped, resulting in blocked growth and development of piglets, piglet diarrhea, and even the death of sows and piglets, causing great economic losses for pig farmers It is a disease that is highly valued by various large and small pig farms.
  • Postpartum fever is mostly caused by blood loss during childbirth, loss of righteousness, or unclean infection at birth; or sows are weak, and the outside is not solid, feel the cold, wind and heat evil; or postpartum lochia can not stop, blood stasis, Long-term heat; or postpartum blood deficiency, lack of Ying Yin, endogenous heat and so on.
  • Chinese medicine treatment of sows in the early stage of postpartum fever not only has the anti-viral effect of Western medicine, but also can help the body and evil spirits, improve the body immunity of sick pigs, select pure natural Chinese herbal medicines, so that the drug effect directly reaches the lesion, the course of treatment Short, good curative effect, long-term application of no drug resistance, no drug residues, low cost and low cost, can effectively control the disease.
  • the technical problem to be solved by the present invention is to provide a postpartum compound feed containing a traditional Chinese medicine additive, and the feed containing the traditional Chinese medicine additive can overcome various defects of the traditional Chinese medicine and the western medicine in the prior art, and has the functions of clearing away heat and detoxifying and supporting
  • the effect of Qibuzheng can improve the body's immunity, improve the body immunity of sick pigs, have a shorter course of treatment, better curative effect, long-term application of no drug resistance, no drug residue, low cost and low cost, which can effectively control the disease.
  • the present invention provides a sow postpartum compound feed comprising the following materials: corn, wheat, millet, DDGS, wheat bran, watermelon pomace, olive residue, kelp, sugar cane juice, horse tooth Bismuth, barley powder, white lentils, green pepper residue, sweet potato powder, black fungus, kiwi juice, corn oil, salt, vitamin premix and trace element premix.
  • each raw material in the feed are: 40-80 parts by weight of corn, 10-20 parts by weight of wheat, 45-60 parts by weight of millet, 10-15 parts by weight of DDGS, 20-30 parts by weight of wheat bran, watermelon rind 15-25 parts by weight of slag, 10-30 parts by weight of olive slag, 10-20 parts by weight of kelp, 10-20 parts by weight of sugar cane juice, 10-30 parts by weight of purslane, 15-20 parts by weight of eucalyptus powder, white lentils 15 -20 parts by weight, 15-20 parts by weight of green pepper residue, 15-20 parts by weight of sweet potato powder, 15-20 parts by weight of black fungus, 10-15 parts by weight of kiwi juice, 2-6 parts by weight of corn oil, 2-4 parts by weight of salt Parts, vitamin premix 0.1-0.5 parts by weight and trace element premix 0.1-0.5 parts by weight.
  • the feed further includes a traditional Chinese medicine additive, and the weight fraction of each raw material in the feed is: 40-80 parts by weight of corn, 10-20 parts by weight of wheat, 45-60 parts by weight of millet, 10-15 parts by weight of DDGS, wheat bran 20-30 parts by weight, watermelon pomace 15-25 parts by weight, olive slag 10-30 parts by weight, kelp 10-20 parts by weight, sugar cane juice 10-20 parts by weight, purslane 10-30 parts by weight, barley powder 15 -20 parts by weight, white lentils 15-20 parts by weight, green pepper slag 15-20 parts by weight, sweet potato flour 15-20 parts by weight, black fungus 15-20 parts by weight, kiwi juice 10-15 parts by weight, corn oil 2-6 Parts by weight, salt 2-4 parts by weight, vitamin premix 0.1-0.5 Parts by weight, 0.1-0.5 parts by weight of the trace element premix, and 1-3 parts by weight of the traditional Chinese medicine additive.
  • the parts by weight of each raw material in the feed are: 60 parts by weight of corn, 15 parts by weight of wheat, 50 parts by weight of millet, 12 parts by weight of DDGS, 28 parts by weight of wheat bran, 20 parts by weight of watermelon pomace, and 22 parts by weight of olive residue.
  • the traditional Chinese medicine additive includes the following raw materials: white thorn flower, pteridophyte, cypress stalk, bottle sage, eucalyptus, shrimp flower, rock pepper grass, cold berry root, big snake medicine, ⁇ , ⁇ , ⁇ Dragon, cliff palm root, hinged rattan, acanthopanax senticosus, red peony, asparagus, ginseng, glutinous rice, Zhimu, Qin dynasty, Gongzizi, Baiwei, Jiexue, Shangyin, Bupleurum, Phyllanthus and thorn Pear root.
  • each raw material medicine in the traditional Chinese medicine additive are: 11-17 parts by weight of white thorn flower, 10-16 parts by weight of wing grass, 12-20 parts by weight of cypress, 12-20 parts by weight of bottle grass 9-18 parts by weight of Yuping, 12-18 parts by weight of shrimp flower, 10-19 parts by weight of rock pepper, 12-19 parts by weight of cold berry root, 10-15 parts by weight of big snake medicine, 10-18 parts by weight of ⁇ 10-17 parts by weight, 10-15 parts by weight of earthworm, 10-18 parts by weight of cliff brown root, 14-25 parts by weight of slashed vine, 25-38 parts by weight of acanthopanax, and 22-33 weight of red peony Serving, 9-15 parts by weight of cohosh, 12-19 parts by weight of ginseng, 12-19 parts by weight of coix seed, 12-19 parts by weight of Zhimu, 15-25 parts by weight of Gentiana, 10-14 parts by weight of glutinous rice, white 12-19 parts by weight of Wei, 10-18 parts by weight of Art
  • the parts by weight of each raw material medicine in the traditional Chinese medicine additive are: 13 parts by weight of white thorn flower, 14 parts by weight of wing grass, 17 parts by weight of cypress, 15 parts by weight of bottle grass, 11 parts by weight of eucalyptus, and shrimp 16 parts by weight of flowers, 14 parts by weight of rock pepper, 18 parts by weight of cold berry root, 10 parts by weight of big snake medicine, 12 parts by weight of ⁇ , 13 parts by weight of peony, 15 parts by weight of earthworm, 11 parts by weight of peony root, 18 parts by weight of slashed vine, 32 parts by weight of acanthopanax, 29 parts by weight of red peony, 13 parts by weight of cohosh, 13 parts by weight of ginseng, 12 parts by weight of coix seed, 16 parts by weight of Zhimu, 21 parts by weight of Gentiana, and credit 11 parts by weight, 16 parts by weight of Baiwei, 17 parts by weight of Artemisia scoparia, 14 parts by weight of Bupleu
  • the preparation method of the traditional Chinese medicine additive comprises the following steps:
  • the raw materials are mixed in proportion, and ethanol having an alcohol concentration of 85 to 95% is added in an amount of 2 to 4 times the mass of the mixture, heated under reflux for 1 to 3 hours, extracted, and filtered to obtain a first extract;
  • the obtained dregs are further added with ethanol having a concentration of alcohol of 85 to 95% relative to the mass of the dregs, and heated under reflux for 1 to 3 hours, extracted, and filtered to obtain a second extract;
  • the first extract is obtained.
  • the second extract is combined, concentrated under reduced pressure to remove the ethanol solvent, and dried to obtain a dry paste;
  • the dry paste obtained in the first step is placed in an ultrafine pulverizer for 1 to 2 hours, pulverized and sieved to obtain an ultrafine powder of 300 mesh to 400 mesh, and a powder of a traditional Chinese medicine additive is obtained.
  • the present invention also provides a method for preparing a sow postpartum compound feed, the preparation method comprising the following steps:
  • Crushing step weigh corn, wheat, millet, DDGS, wheat bran, watermelon slag, olive slag, kelp, purslane, white lentils, green pepper slag and black fungus according to the weight ratio, and put it into the pulverizer. Finely pulverized, passed through a 2.0mm sieve after pulverization;
  • step (1) weigh sugar cane juice, barley powder, sweet potato powder, kiwi juice, corn oil, salt, vitamin premix, trace element premix and traditional Chinese medicine additive according to the weight ratio, and pulverize with step (1)
  • the obtained fine powder is mixed, put into a mixer, and uniformly mixed, and the mixing time is 30-60 s;
  • Granulation step granulation is carried out by a granulator, and the granulation temperature is 85 ° C, and the degree of gelatinization is 90% or more.
  • the feed of the invention contains the traditional Chinese medicine additive having the functions of clearing away heat and detoxifying, qi and correcting the qi, and can improve the body immunity of the sick pig, has a shorter course of treatment, better curative effect, long-term application. It has no drug resistance, no drug residue, low cost and other advantages.
  • Traditional Chinese medicine additives and other feed ingredients work together to interact with each other. It can not only treat postpartum fever in sows, but also meet the nutritional needs of sick pigs. It is especially suitable for mothers. Nutritional needs of pigs with postpartum fever.
  • Traditional Chinese medicine additive refers to the traditional theory of the relationship between the physical properties of Chinese herbal medicines (yin, yang, cold, freezing, warm, hot), odor (acid, sweet, bitter, spicy, salty) and matter.
  • Chinese herbal medicine additives or mixtures Based on the theory and technology of the breeding and feed industries, we have developed single and complex Chinese herbal medicine additives or mixtures. From the modern pharmacological analysis, the feed additive based on the active ingredients of Chinese herbal medicine has the immune function and non-specific antibacterial effect of regulating the body.
  • the Chinese herbal medicine contains alkaloids, polysaccharides, volatile oils of organic acids, organic acid flavonoids and organisms. Biological active substances such as flavonoids have a good effect on regulating the body's immune function and improving health.
  • polysaccharides have the ability to promote thymus response and stimulate reticuloendothelial cells to increase specific antigen response; alkaloids can enhance humoral and cellular immune functions, and stimulate the phagocytic function of macrophages, which can enhance the reticuloendothelial system.
  • the phagocytic function promotes antibody production, promotes antigen-antibody reaction and lymphocyte transformation of organic acids, regulates the intestinal tract and prevents the proliferation of harmful bacteria and enhances the activity of the enzyme, so that the metabolism of the animal can proceed normally.
  • Chinese medicine feed additives not only contain a certain amount of nutrients, but also contain a certain number of unknown growth regulators and pigments, which directly or indirectly activate the body's biochemical reactions, enhance biosynthesis, and thus promote animals. Production performance.
  • the traditional Chinese medicine additive of the invention is mainly based on the theory of Chinese medicine strengthening and correcting evil spirits, and the theory of traditional Chinese medicine believes that Fuzheng and Xiexie are two aspects of mutual connection, and the support is precisely for the evil spirits, and the method of strengthening the righteousness is used to exorcise the evil spirits, thereby restoring health, that is, the so-called "positive ghosts are self-defeating.”
  • the evil spirit is to help the right, to eliminate the damage caused by the disease, and to achieve the purpose of protecting the righteousness and restoring health, that is, the so-called “evil is going to be self-reliant.”
  • the righteousness and the evil spirits are two aspects that complement each other.
  • the traditional Chinese medicine additive adheres to the basic principle of "supporting the righteousness and eliminating evil spirits", and follows the principle of clearing heat and detoxification and qi and correcting, and provides a sow postpartum feed, which includes traditional Chinese medicine additives
  • the traditional Chinese medicine additives include the following raw materials: white thorn flower, wing Shoucao, Shuibaizhi, Juer Grass, ⁇ ping, shrimp flower, rock pepper, cold berry root, big snake medicine, ⁇ , ⁇ ⁇ , earth dragon, cliff palm root, hinged vine, acanthopanax senticosus, red peony, cohosh, ginseng, coix seed, Zhimu, Qinhuang, Gonglazi, Baiwei, Jiexuehao, Shanyin Bupleurum, Yuganzi and Prickly Pear Root.
  • White thorn flower alias white flower thorn ("Guizhou Herbal Medicine"), bitter flower (“Wenshan Chinese Herbal Medicine”).
  • 2 "Wenshan Chinese Herbal Medicine”: “Qingshan detoxification, dampness and swelling. Treatment of dysentery, cystitis, hematuria, edema.”
  • Wing grass alias stick head, lion grass.
  • Bitter cold. Clear heat and clear the table, clear heart and cool blood. It is used for fever caused by cold and fever, all kinds of fever, heart trouble, hemoptysis, vomiting blood, hematuria, blood in the stool.
  • Sycamore branch alias sand willow, stinky red willow. It is a singularity of the cypress plant of the genus Salix, and the young branch is used as a medicine. Sex, sweet, warm. Published a rash. For measles is not transparent.
  • Bottle grass alias an arrow, a gun, a single arrow, a single gun, a spear and a shield, contradictory grass, snake grass.
  • the bottle of grass, the grass, or the stalk of the bottle is used as a whole herb.
  • Qingrejiedu swelling and pain.
  • alias Ma algae (" ⁇ "), Bian Yuping ("Auxiliary”), water hundred feet, ⁇ scoop, water tongue grass (“Shanghai commonly used Chinese herbal medicine”), Dapuping, Bao Tianma (" Guizhou Herbs), Ma Ping, Da Yuping ("Fujian Chinese Herbal Medicine”). It is the whole grass of the genus Eucalyptus. Xin; bitter; cold. Clear heat and clear the table; diuretic swelling; detoxification. Main wind and cold; measles is not transparent; edema, hot shower, urination is unfavorable; enthusiasm; hemorrhoids, swollen sores; erysipelas; mumps, eczema; burns.
  • Shrimp flowers alias red honey flower, Wu Fuhua, wild safflower, broken blood medicine, sand flower, shrimp flower. Thousands of prawn flowers, rooted and flowered. Slightly sweet, sturdy, warm. Tiaojing Huoxue, cooling blood to stop bleeding, pass through the active. Indications for women with blood collapse, irregular menstruation, rheumatoid arthritis, lumbar muscle strain, nasal discharge, hemoptysis.
  • Rock pepper grass alias stinking grass ("plant name map”), pine wind grass (“Botanical Dictionary”), stone pepper, smelly sand ("Sichuan Chinese Medicine”). It is the whole grass of the musk plant of the musk plant. Xin; bitter; cold to the lungs; liver; spleen. Solution table; truncated malaria; blood circulation; detoxification. Main cold and fever; bronchitis; malaria; gastroenteritis; bruises; hemorrhoids; burns.
  • Cold Raspberry Root The root of the cold berry of the Rosaceae plant. Bitter; acid; cold. Return to the liver; kidney. Clearing away heat and detoxification; promoting blood circulation and relieving pain. Main damp heat jaundice; postpartum fever; high fever in children; irregular menstruation; excessive vaginal discharge; stomach pain folic acid; hemorrhoids swelling and pain;
  • Big snake medicine alias Apo umbrella, fire bud wood, cool umbrella wood ("Guangxi practical Chinese herbal medicine new selection"). For the five plus plant, the roots and bark of the umbrella maple. Taste bitter; cool. Cool blood and detoxification; swelling and pain. Main cold fever; heat stroke headache; swollen poison; phlegm; rheumatic pain; bruises; snake bites.
  • Putian ⁇ alias Mao berry root ("Fujian Chinese Herbal Medicine").
  • Raspberry plant Raspberry Sweet and bitter; cool. Liver; lung; kidney. Detoxification; phlegm and dampness; blood circulation and cooling. Main cold fever; sore throat; rheumatic pain; hepatitis; enteritis; dysentery; nephritis edema; urinary tract infection; stones; bruises; hemoptysis; vomiting blood; uterine bleeding; hemorrhoids swollen; mumps.
  • Dianthus is a genus of plants, which is used as a whole herb. Sweet, sour, cool. Detoxification, phlegm and pain, prolactin. For enteritis, dysentery, hepatitis, appendicitis, postpartum blood stasis, uterine contraction pain, toothache, hair whitening, breast milk, mastitis, bruises, sore swollen poison.
  • Earth dragon salty, cold. Liver, spleen, bladder. Clear heat and shock, Tongluo, asthma, diuretic. For high fever, fainting, seizures, convulsions, joint pain, limb numbness, hemiplegia, lung heat, cough, edema, and high blood pressure.
  • Cliff palm root alias dry grass.
  • the base of the medicinal material the root of the genus Sedum. Sweet; Xin; sexual temperature. Return to the lungs; liver; kidney. Replenishing qi and nourishing blood; promoting blood circulation and regulating menstruation. Main qi and blood are weak; burnout is powerless; palpitations are insomnia; irregular menstruation;
  • Hinge-cut vine alias is more than cut vine.
  • the base of the medicinal material the whole plant of the dicotyledonous plant of the dicotyledonous plant. Gan; Ping. Return to the liver; spleen. Replenishing qi and nourishing blood; Main postpartum weakness; postpartum lack of milk.
  • Acanthopanax senticosus Xin, slightly bitter, warm. Return to the spleen, kidney, heart. Replenishing qi and strengthening the spleen For spleen and kidney yang deficiency, physical weakness, loss of appetite, waist and knee pain, insomnia and more dreams.
  • Red dragonfly alias rock jaundice, black cockroach.
  • This product is the dry root of the multi-order rock Astragalus membranaceus. Gan, warm. Return to the lungs, spleen. Invigorating the qi and solidifying the table, diuretic toxic, pus, and sore muscles.
  • qi deficiency lack of food, stool, gas sag, long-term diarrhea, rectal prolapse, blood stasis, table soft self-sweat, qi edema, phlegm and blood stasis, blood deficiency and chlorosis, internal heat and thirst, chronic nephritis proteinuria, diabetes.
  • Cimicifuga alias yak card holder, longan root, hole root. This product is the dry rhizome of Ranunculaceae plant big three leaf cohosh, Xing'an cohosh or cohosh. Xin, slightly sweet, slightly cold. Return to the lungs, spleen, stomach, large intestine. Published a rash, clearing away heat and detoxifying, and raising yang. For wind-heat headache, toothache, mouth sores, sore throat, measles impervious, yang poisoning spots; rectal prolapse, uterine prolapse.
  • Ginseng alias palm ginseng, palm ginseng, yin and yang. It is the root of the ginseng of the orchid family. Sweet, slightly bitter, cool. Bushen Yijing, qi and pain. After the illness, the body is weak, neurasthenia, cough, impotence, long-term diarrhea, vaginal discharge, bruises, bruises and swelling.
  • Coix seed This product is a dry mature core of the Rosaceae plant nucleus or the sclerotium. Gan, slightly cold. Go to the liver. Live the liver and improve eyesight, and cool the wind. It is used for redness and swelling of the eyes, and the strings are red and shame.
  • Zhimu Alias garlic scorpion grass, sheep beard root, and ground ginseng. This product is the dried rhizome of the lily family. Bitter, sweet, cold. Return to the lungs, stomach, kidney. Clearing heat and purging fire, Shengjin Runzao. For exogenous fever, high fever and polydipsia, lung heat dry cough, bone steaming hot flashes, internal heat and thirst, intestinal dry constipation.
  • Qin Lan aliases such as braid, Xiao Qin, Datun, Xi Dawei, Zuo Tuan, Zuo Jin, Xi Qin, Zuo Qin, Radish, and Scorpion.
  • This product is the dried root of Gentiana macrophylla, Gentiana straminea, Rhizoma chinensis or Gentiana straminea.
  • Xin bitter, flat.
  • Bai Wei Alias white horse tail. This product is the dried root and rhizome of the white radix or the white radish. Bitter, salty, cold. Return to the stomach, liver, kidney. Clearing heat and cooling blood, diuretic Tonglin, detoxification treatment of sores. It is used for warming evil camps, fever, yin deficiency and fever, bone steaming and heat, postpartum blood deficiency and fever, hot shower, bloody, phlegm and swollen poison.
  • alias Purna (Tibetan name).
  • alias Purna (Tibetan name).
  • Shanyin Bupleurum the root of the genus Dianthus, the genus of the genus Dianthus, or the root of the genus Hydrangea. Gan; sexually cold. Return to the lungs; liver; gallbladder; kidney; stomach. Cool blood; clear heat.
  • Yu Ganzi alias ⁇ olive, olive [Yunnan. Sichuan], ⁇ Muller, oil citrus.
  • the roots, leaves, bark, etc. can also be used as medicine.
  • blood and blood stasis hepatobiliary disease, indigestion, abdominal pain, cough, sore throat, dry mouth.
  • Ciqizi root Alias Ciqizi root ("Tianbao Materia Medica"), Ciqigen ("Guiyang Folk Herbs”). It is the root of the rosewood plant. Glycolic acid; flat; non-toxic. Return to the spleen; stomach; liver; kidney. Jianweixiaoshi, pain relief, contraction, stop bleeding. The main stomach cramps are full of pain, toothache, sore throat, chronic cough, diarrhea, nocturnal emission, vaginal discharge, uterine bleeding.
  • the preparation method comprises the following steps:
  • the raw materials are mixed in proportion, and ethanol having an alcohol concentration of 95% relative to the mass of the mixture is added, heated under reflux for 2 hours, extracted, and filtered to obtain a first extract; and the obtained dregs are filtered.
  • ethanol having a concentration of alcohol of 95% with respect to the mass of the dregs heating under reflux for 2 hours, extracting, and filtering to obtain a second extract; combining the first extract and the second extract, and concentrating the ethanol under reduced pressure Solvent, dry, to obtain a dry paste;
  • the dry paste obtained in the first step is placed in an ultrafine pulverizer for 1 hour, pulverized and sieved to obtain an ultrafine powder of 300 mesh, and a powder of a traditional Chinese medicine additive is obtained.
  • the embodiment of the present invention provides a sow postpartum compound feed, wherein the weight fraction of each raw material in the feed is: 60 parts by weight of corn, 15 parts by weight of wheat, 50 parts by weight of millet, 12 parts by weight of DDGS, 28 parts by weight of wheat bran, 20 parts by weight of watermelon rind, 22 parts by weight of olive slag, 15 parts by weight of kelp, 18 parts by weight of sugar cane juice, 25 parts by weight of purslane, 16 parts by weight of eucalyptus powder, 18 parts by weight of white lentils, 17 parts by weight of green pepper slag, sweet potato 16 parts by weight of powder, 19 parts by weight of black fungus, 13 parts by weight of kiwi juice, 5 parts by weight of corn oil, 3 parts by weight of salt, 0.4 parts by weight of vitamin premix, and 0.3 parts by weight of a trace element premix.
  • the preparation method comprises the following steps:
  • Crushing step weigh corn, wheat, millet, DDGS, wheat bran, watermelon slag, olive slag, kelp, purslane, white lentils, green pepper slag and black fungus according to the weight ratio, and put it into the pulverizer. Finely pulverized, passed through a 2.0mm sieve after pulverization;
  • Granulation step granulation is carried out by a granulator, and the granulation temperature is 85 ° C, and the degree of gelatinization is 90% or more.
  • the embodiment of the invention provides a sow postpartum compound feed, wherein the weight fraction of each raw material in the feed is: 60 parts by weight of corn, 15 parts by weight of wheat, 50 parts by weight of millet, DDGS 12 28 parts by weight of wheat bran, 20 parts by weight of watermelon slag, 22 parts by weight of olive slag, 15 parts by weight of kelp, 18 parts by weight of sugar cane juice, 25 parts by weight of purslane, 16 parts by weight of eucalyptus powder, and 18 parts by weight of white lentils Serving, 17 parts by weight of green pepper residue, 16 parts by weight of sweet potato powder, 19 parts by weight of black fungus, 13 parts by weight of kiwi juice, 5 parts by weight of corn oil, 3 parts by weight of salt, 0.4 parts by weight of vitamin premix, and trace element premix 0.3 parts by weight and 3 parts by weight of a traditional Chinese medicine additive; wherein the traditional Chinese medicine additive is the traditional Chinese medicine additive powder of Example 1.
  • the preparation method comprises the following steps:
  • Crushing step weigh corn, wheat, millet, DDGS, wheat bran, watermelon slag, olive slag, kelp, purslane, white lentils, green pepper slag and black fungus according to the weight ratio, and put it into the pulverizer. Finely pulverized, passed through a 2.0mm sieve after pulverization;
  • step (1) weigh sugar cane juice, barley powder, sweet potato powder, kiwi juice, corn oil, salt, vitamin premix, trace element premix and traditional Chinese medicine additive according to the weight ratio, and pulverize with step (1)
  • the obtained fine powder is mixed, put into a mixer, and uniformly mixed, and the mixing time is 50 s;
  • Granulation step granulation is carried out by a granulator, and the granulation temperature is 85 ° C, and the degree of gelatinization is 90% or more.
  • the decoction liquid is filtered to obtain a first filtrate, and the filter residue is collected; the filter residue obtained by filtration is again added to 1400 g of cold water, and decocted three times with a simmer, each time of boiling for 1 hour, and the filtrate is filtered and combined to obtain a second filtrate; The filtrate was combined twice, and a part of water was removed by concentration under reduced pressure to obtain a decoction having a crude drug concentration of 3 g/ml.
  • Test method SD rats were selected and given different concentrations (18.0, 6.0, 2.0g).
  • the crude Chinese medicine additive of the present invention is administered once a day for 90 days, and 1/2 animals (male and female) are killed in each group 24 hours after the last administration, and the remaining 1/2 animals continue to observe. Killed after 2 weeks. Animals were observed for appearance, general behavior, food intake, body weight change, hematology (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemistry (90 days after dosing and 2 weeks after drug withdrawal).
  • the Chinese medicine additive of the present invention had good general condition in the high, medium and low dose groups, and there was no abnormal change in appearance signs, behavioral activities, food intake and body weight growth; hematological examination and blood in the three dose groups and the control group
  • the biochemistry and urine biochemical tests were all in the normal range, and there was no significant difference between the groups.
  • the above indicators did not change after 2 weeks of withdrawal.
  • the dosage of the test is 180, 60, and 20 times of the clinical dose, respectively.
  • the traditional Chinese medicine preparation of the present invention is administered in three doses of high, medium and low doses (18.0, 6.0, 2.0 g crude drug/kg) for 90 consecutive days. There was no significant effect on rats, no clear toxic target organs and sensitive indicators, and no delayed toxicity was observed during the recovery period, suggesting that the dose safety of the traditional Chinese medicine preparations of the present invention is high.
  • Example group 1 was fed with the feed of Example 2 of the present invention, and Example Group 2 was fed with the feed of Example 3, and the control group was treated with conventional feed and conventional medicine; wherein the traditional drug in the control group was penicillin.
  • Example group 1 50 heads 48 heads 2 heads 96%
  • Example group 2 50 heads 50 heads 0 head 100%
  • the feeds of Examples 2 and 3 of the present invention have the advantages of small toxic and side effects, remarkable curative effect, and ability to meet the nutritional needs of sick pigs compared with the conventional drugs.
  • the feed was added to 7 times of warm water and stirred into a paste to the sick pig. After 1 hour, the body temperature was normal, and the appetite recovered after 4 hours. After 8 hours, the purulent secretion in the vagina was significantly reduced, and healed after 12 hours. There was no recurrence after the return visit in March.

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Abstract

一种母猪产后配合饲料及其制备方法,其中饲料包括以下原料:玉米、小麦、小米、DDGS、麦麸、西瓜皮渣、橄榄渣、海带、甘蔗汁、马齿苋、青稞粉、白扁豆、青椒渣、红薯粉、黑木耳、猕猴桃汁、玉米油、食盐、维生素预混料和微量元素预混料;其制备方法包括以下步骤:破碎步骤、配料步骤、制粒步骤。

Description

母猪产后配合饲料及其制备方法 技术领域
本发明涉及动物饲料,特别涉及一种母猪产后配合饲料及其制备方法。
背景技术
母猪生殖道寄生大量细菌,包括需氧菌、厌氧菌、真菌、衣原体及支原体等,以厌氧菌为主。常见的致病菌主要有:需氧性链球菌、厌氧性革兰阳性球菌、大肠杆菌属、葡萄球菌、类杆菌属、厌氧芽孢梭菌、衣原体、支原体以及淋病奈瑟菌等。许多非致病菌在特定环境下可以致病。母猪产后发热是由致病菌在产前、产时或产后侵入生殖道而于产后引起局部或全身发生炎性变化。临床以急性子宫内膜炎最为常见,严重者可发展为急性宫旁组织炎、盆腔腹膜炎、血栓性静脉炎,甚至败血症、中毒性休克而威胁生命。
母猪产后发热是母猪产后常见的一种疾病,常在母猪产后1-7天,表现为母猪发烧、食欲减退或废绝,母猪体温升高到41℃左右,精神沉郁,卧地不起,寒战,阴道中有脓性分泌物流出,泌乳减少或停止,从而造成仔猪生长发育受阻、仔猪腹泻,甚至造成母猪和仔猪的死亡,给养猪户造成很大的经济损失,是各个大小型养猪场十分重视的一种疾病。
产后发热多因分娩时失血耗气,正气亏损,或产时不洁感染邪毒;或母猪元气虚弱,卫外不固,感受风寒、风热之邪;或产后恶露不下,瘀血停滞,瘀久化热;或产后血虚,营阴不足,虚热内生等引起。
对于该病的治疗,目前在临床上还没有特效药物和有效的方法,常规西医治疗用青霉素、链霉素、四环素、土霉素等抗菌药物杀菌、消炎、退烧等,但效果并不理想。
但是中医药治疗母猪产后发热初期不仅具有西医药的抗病毒等作用,还可扶正祛邪,提高患病猪的机体免疫力,精选纯天然中药材,使药效直接到达病灶,疗程较短,疗效较好,长期应用无耐药性,无药物残留,成本价格低廉,可以有效的控制病情。
发明内容
本发明所要解决的技术问题是在于提供一种含有中药添加剂的母猪产后配合饲料,采用含有这种中药添加剂的饲料能克服现有技术中的中药和西药的各种缺陷,具有清热解毒、扶气补正的作用,可扶正祛邪,提高患病猪的机体免疫力,疗程较短,疗效较好,长期应用无耐药性,无药物残留,成本价格低廉,可以有效的控制病情。
为了实现上述发明目的,本发明提供了一种母猪产后配合饲料,所述饲料包括以下原料:玉米、小麦、小米、DDGS、麦麸、西瓜皮渣、橄榄渣、海带、甘蔗汁、马齿苋、青稞粉、白扁豆、青椒渣、红薯粉、黑木耳、猕猴桃汁、玉米油、食盐、维生素预混料和微量元素预混料。
所述饲料中各原料的重量份数为:玉米40-80重量份、小麦10-20重量份、小米45-60重量份、DDGS 10-15重量份、麦麸20-30重量份、西瓜皮渣15-25重量份、橄榄渣10-30重量份、海带10-20重量份、甘蔗汁10-20重量份、马齿苋10-30重量份、青稞粉15-20重量份、白扁豆15-20重量份、青椒渣15-20重量份、红薯粉15-20重量份、黑木耳15-20重量份、猕猴桃汁10-15重量份、玉米油2-6重量份、食盐2-4重量份、维生素预混料0.1-0.5重量份和微量元素预混料0.1-0.5重量份。
所述饲料还包括中药添加剂,所述饲料的中各原料的重量份数为:玉米40-80重量份、小麦10-20重量份、小米45-60重量份、DDGS10-15重量份、麦麸20-30重量份、西瓜皮渣15-25重量份、橄榄渣10-30重量份、海带10-20重量份、甘蔗汁10-20重量份、马齿苋10-30重量份、青稞粉15-20重量份、白扁豆15-20重量份、青椒渣15-20重量份、红薯粉15-20重量份、黑木耳15-20重量份、猕猴桃汁10-15重量份、玉米油2-6重量份、食盐2-4重量份、维生素预混料0.1-0.5 重量份、微量元素预混料0.1-0.5重量份和中药添加剂1-3重量份。
所述饲料中各原料的重量份数为:玉米60重量份、小麦15重量份、小米50重量份、DDGS 12重量份、麦麸28重量份、西瓜皮渣20重量份、橄榄渣22重量份、海带15重量份、甘蔗汁18重量份、马齿苋25重量份、青稞粉16重量份、白扁豆18重量份、青椒渣17重量份、红薯粉16重量份、黑木耳19重量份、猕猴桃汁13重量份、玉米油5重量份、食盐3重量份、维生素预混料0.4重量份、微量元素预混料0.3重量份和中药添加剂3重量份。
所述中药添加剂包括以下原料药材:白刺花、翼首草、水柏枝、瓶尔小草、蜈蚣萍、虾子花、岩椒草、寒莓根、大蛇药、薅田藨根、繁缕、地龙、崖棕根、铰剪藤、刺五加、红芪、升麻、手参、蕤仁、知母、秦艽、功劳子、白薇、结血蒿、山银柴胡、余甘子和刺梨根。
所述中药添加剂中各原料药材的重量份数为:白刺花11-17重量份、翼首草10-16重量份、水柏枝12-20重量份、瓶尔小草12-20重量份、蜈蚣萍9-18重量份、虾子花12-18重量份、岩椒草10-19重量份、寒莓根12-19重量份、大蛇药10-15重量份、薅田藨根10-18重量份、繁缕10-17重量份、地龙10-15重量份、崖棕根10-18重量份、铰剪藤14-25重量份、刺五加25-38重量份、红芪22-33重量份、升麻9-15重量份、手参12-19重量份、蕤仁12-19重量份、知母12-19重量份、秦艽15-25重量份、功劳子10-14重量份、白薇12-19重量份、结血蒿10-18重量份、山银柴胡10-18重量份、余甘子12-21重量份和刺梨根8-15重量份。
所述中药添加剂中各原料药材的重量份数为:白刺花13重量份、翼首草14重量份、水柏枝17重量份、瓶尔小草15重量份、蜈蚣萍11重量份、虾子花16重量份、岩椒草14重量份、寒莓根18重量份、大蛇药10重量份、薅田藨根12重量份、繁缕13重量份、地龙15重量份、崖棕根11重量份、铰剪藤18重量份、刺五加32重量份、红芪29重量份、升麻13重量份、手参13重量份、蕤仁12重量份、知母16重量份、秦艽21重量份、功劳子11重量份、白薇16重量份、结血蒿17重量份、山银柴胡14重量份、余甘子18重量份和刺梨根 9重量份。
所述中药添加剂的制备方法包括以下步骤:
第一步,将所述各原料药材按比例混合,加入相对于混合物质量2~4倍的醇浓度为85~95%的乙醇,加热回流1~3小时,提取,过滤获得第一提取液;过滤获得的药渣再加入相对于所述药渣质量1~2倍的醇浓度为85~95%的乙醇,加热回流1~3小时,提取,过滤获得第二提取液;将第一提取液和第二提取液合并,减压浓缩除去乙醇溶剂,干燥,获得干膏;
第二步,将第一步获得的干膏放置在超微粉碎机中粉碎1~2小时,粉碎,过筛,获得300目~400目的超微细粉,获得中药添加剂散剂。
为了更好的实现发明目的,本发明还提供一种母猪产后配合饲料的制备方法,所述制备方法包括以下步骤:
(1)破碎步骤:按重量份数比称取玉米、小麦、小米、DDGS、麦麸、西瓜皮渣、橄榄渣、海带、马齿苋、白扁豆、青椒渣和黑木耳,投入粉碎机进行微粉碎,经过粉碎后过2.0mm筛;
(2)配料步骤:按照重量份数比称取甘蔗汁、青稞粉、红薯粉、猕猴桃汁、玉米油、食盐、维生素预混料、微量元素预混料和中药添加剂,与步骤(1)粉碎获得的细粉混合,投入混合机,混合均匀,混合时间为30-60s;
(3)制粒步骤:投入制粒机进行制粒,制粒温度为85℃,使其糊化度达到90%以上。
本发明的有益效果是:本发明的饲料含有具有清热解毒、扶气补正的作用的中药添加剂,可扶正祛邪,提高患病猪的机体免疫力,具有疗程较短,疗效较好,长期应用无耐药性,无药物残留,成本价格低廉等优势,中药添加剂与其他饲料原料相互配合,互相作用,不仅能够治疗母猪产后发热,还能够满足病猪的营养需求,特别适用于患有母猪产后发热病猪的营养需求。
具体实施方式
中药添加剂是指以我国对大自然中草药的物性(阴、阳、寒、冻、温、热)、物味(酸、甘、苦、辣、咸)和物质关系的传统理论为主导、并以饲养和饲料业等学科理论及技术为依托,所研制的单一和复合型的中草药添加剂或混合剂。从现代药理学分析,以中草药有效成分为主体的饲料添加剂,具有调节机体的免疫功能以及非特异性抗菌作用,中草药含有抗抑菌成份的生物碱、多糖、贰类挥发油、有机酸类黄酮和生物类黄酮等生物活性物质,对调节机体免疫机能,提高健康水平有良好的作用。据报道,多糖具有促进胸腺反应、刺激网状内皮细胞提高特异性抗原反应能力;生物碱能增强体液与细胞免疫功能,以及刺激巨噬细胞的吞噬功能,贰类挥发油可增强网状内皮系统的吞噬功能,并可促进抗体生成,促进抗原抗体反应和淋巴细胞转化有机酸,能调节肠内并防止有害细菌的繁殖和提高酶的活性,使动物体内新陈代谢能正常进行。从现代营养学的理论分析中药饲料添加剂不仅含有一定数量的营养物质,而且还含有一定数量的未知生长调节因子和色素,具有直接或间接地激活机体的生化反应,增强生物合成作用,从而促进动物的生产性能。
本发明中药添加剂主要根据中医扶正祛邪理论,中医理论认为扶正和祛邪是相互联系的两个方面,扶正是为了祛邪,通过增强正气的方法,驱邪外出,从而恢复健康,即所谓“正盛邪自祛”。祛邪是为了扶正,消除致病因素的损害而达到保护正气,恢复健康的目的,即所谓“邪去正自安”。扶正与祛邪是相辅相成的两个方面。因此运用扶正祛邪的治则时,要认真仔细分析正邪力量的对比情况,分清主次,决定扶正或祛邪,或决定扶正祛邪的先后。一般情况下,扶正用于虚证;祛邪用于实证;若属虚实错杂证,则应扶正祛邪并用,但这种兼顾并不是扶正与祛邪各半,乃是要分清虚实的主次缓急,以决定扶正祛邪的主次、先后。总之,应以“扶正不致留邪,祛邪不致伤正”为度。
本发明中药添加剂遵循“扶正祛邪”的基本原理,遵循清热解毒、扶气补正的原则,提供了一种母猪产后饲料,其包括中药添加剂,中药添加剂包括以下原料药材:白刺花、翼首草、水柏枝、瓶尔小草、 蜈蚣萍、虾子花、岩椒草、寒莓根、大蛇药、薅田藨根、繁缕、地龙、崖棕根、铰剪藤、刺五加、红芪、升麻、手参、蕤仁、知母、秦艽、功劳子、白薇、结血蒿、山银柴胡、余甘子和刺梨根。其中,白刺花、翼首草、水柏枝、瓶尔小草、蜈蚣萍清热解毒;虾子花、岩椒草、寒莓根、大蛇药、薅田藨根、繁缕、地龙活血凉血;崖棕根、铰剪藤益气养血;刺五加、红芪、升麻、手参、蕤仁补气扶正;知母、秦艽、功劳子、白薇、结血蒿、山银柴胡清退虚热;余甘子、刺梨根消食健胃纵观全方,配伍严谨。
上述各原料药材的药理特性如下:
白刺花:别名白花刺(《贵州草药》),苦刺花(《文山中草药》)。为豆科植物白刺花的根。味苦;性凉。归肝;膀胱经。清热解暑。主暑热烦渴。①《贵州草药》:"清热,凉血,解毒。治鼻血,便血。"②《文山中草药》:"清热解毒,利湿消肿。治痢疾,膀胱炎,血尿,水肿。"
翼首草:别名棒子头、狮子草。川续断科翼首花属植物匙叶翼首花,以带根全草入药。苦,寒。清热解表,清心凉血。用于感冒发热及各种温热病引起的发烧,心中烦热,咳血,吐血,尿血,便血。
水柏枝:别名砂柳、臭红柳。为怪柳科水柏枝属植物水柏枝,以幼枝入药。性味辛、甘,温。发表透疹。用于麻疹不透。
瓶尔小草:别名一支箭、一支枪、独叶一支箭、单枪一支箭、一矛一盾、矛盾草、蛇须草。瓶尔小草科植物瓶尔小草或有梗瓶尔小草,以全草入药。微甘、酸,凉。清热解毒,消肿止痛。用于小儿肺炎,脘腹胀痛,毒蛇咬伤,疔疮肿毒;外用治急性结膜炎,角膜云翳,眼睑缘炎。
蜈蚣萍:别名麻藻(《群芳谱》),边箕萍(《纲目拾遗》),水百脚、槐瓢、水舌头草(《上海常用中草药》),大浮萍、包田麻(《贵州草药》),马萍、大鱼萍(《福建中草药》)。为槐叶苹科植物槐叶苹的全草。辛;苦;性寒。清热解表;利水消肿;解毒。主风热感冒;麻疹不透;浮肿,热淋,小便不利;热痢;痔疮,痈肿疗疮;丹毒;腮腺炎,湿疹;烫火伤。
虾子花:别名红蜂蜜花、吴福花、野红花、破血药、沙花、虾花。千屈菜科虾子花,以根、花入药。微甘、涩,温。调经活血,凉血止血,通经活络。主治妇女血崩,月经不调,风湿关节炎,腰肌劳损,鼻衄,咳血。
岩椒草:别名臭节草(《植物名实图考》),松风草(《植物学大辞典》),石胡椒、臭沙子(《四川中药志》)。为芸香种植物臭节草的全草。辛;苦;性凉归肺;肝;脾经。解表;截疟;活血;解毒。主感冒发热;支气管炎;疟疾;胃肠炎;跌打损伤;痈疽疮肿;烫伤。
寒莓根:为蔷薇科植物寒莓的根。苦;酸;寒。归肝;肾经。清热解毒;活血止痛。主湿热黄疸;产后发热;小儿高热;月经不调;白带过多;胃痛叶酸;痔疮肿痛;肛门漏管。
大蛇药:别名阿婆伞、火蕾木、凉伞木(《广西实用中草药新选》)。为五加种植物幌伞枫的根及树皮。味苦;性凉。凉血解毒;消肿止痛。主感冒发热;中暑头痛;痈疖肿毒;瘰疬;风湿痹痛;跌打损伤;毒蛇咬伤。
薅田藨根:别名茅莓根(《福建中草药》)。为蔷薇科植物茅莓的根。甘苦;凉。归肝;肺;肾经。清热解毒;祛风利湿;活血凉血。主感冒发热;咽喉肿痛;风湿痹痛;肝炎;肠炎;痢疾;肾炎水肿;尿路感染;结石;跌打损伤;咳血;吐血;崩漏;疔疮肿毒;腮腺炎。
繁缕:别名鹅儿肠、鸡肠菜、合筋草、小被单草、园酸菜。石竹科繁缕属植物繁缕,以全草入药。甘、酸,凉。清热解毒,化瘀止痛,催乳。用于肠炎,痢疾,肝炎,阑尾炎,产后瘀血腹痛,子宫收缩痛,牙痛,头发早白,乳汁不下,乳腺炎,跌打损伤,疮疡肿毒。
地龙:咸,寒。归肝、脾、膀胱经。清热定惊,通络,平喘,利尿。用于高热神昏,惊痫抽搐,关节痹痛,肢体麻木,半身不遂,肺热喘咳,尿少水肿,高血压。
崖棕根:别名干经草。药材基源:为莎草科植物芝叶苔草的根。味甘;辛;性温。归肺;肝;肾经。益气养血;活血调经。主气血虚弱;倦怠无力;心悸失眠;月经不调;经闭。
铰剪藤:别名较剪藤。药材基源:为双子叶植物药萝藦科植物铰剪藤的全株。甘;平。归肝;脾经。益气养血;通经下乳。主产后虚弱;产后缺乳。
刺五加:辛、微苦,温。归脾、肾、心经。益气健脾,补肾安神。用于脾肾阳虚,体虚乏力,食欲不振,腰膝酸痛,失眠多梦。
红芪:别名岩黄芪、黑芪。本品为豆科植物多序岩黄芪的干燥根。甘,温。归肺、脾经。补气固表,利尿托毒,排脓,敛疮生肌。用于气虚乏力,食少便溏,中气下陷,久泻脱肛,便血崩漏,表虚自汗,气虚水肿,痈疽难溃,血虚萎黄,内热消渴,慢性肾炎蛋白尿,糖尿病。
升麻:别名莽牛卡架、龙眼根、窟窿牙根.本品为毛茛科植物大三叶升麻、兴安升麻或升麻的干燥根茎。辛、微甘,微寒。归肺、脾、胃、大肠经。发表透疹,清热解毒,升举阳气。用于风热头痛,齿痛,口疮,咽喉肿痛,麻疹不透,阳毒发斑;脱肛,子宫脱垂。
手参:别名手掌参、掌参、阴阳参。为兰科手参属植物手参的块根。甘、微苦,凉。补肾益精,理气止痛。病后体弱,神经衰弱,咳嗽,阳痿,久泻,白带,跌打损伤,淤血肿痛。
蕤仁:本品为蔷薇科植物蕤核或齿叶扁核木.的干燥成熟果核。甘,微寒。归肝经。养肝明目,疏风散热。用于目赤肿痛,睑弦赤烂,目暗羞明。
知母:别名蒜辫子草、羊胡子根、地参。本品为百合科植物知母的干燥根茎。苦、甘,寒。归肺、胃、肾经。清热泻火,生津润燥。用于外感热病,高热烦渴,肺热燥咳,骨蒸潮热,内热消渴,肠燥便秘。
秦艽:别名麻花艽、小秦艽、大艽、西大艽、左扭、左拧、西秦艽、左秦艽、萝卜艽、辫子艽。本品为龙胆科植物秦艽、麻花秦艽、粗茎秦艽或小秦艽的干燥根。辛、苦,平。归胃、肝、胆经。祛风湿,清湿热,止痹痛。用于风湿痹痛,筋脉拘挛,骨节酸痛,日晡潮热,小儿疳积发热。
功劳子:为小檗科植物阔叶十大功劳、细叶十大功劳或华南十大功劳的果实。苦;凉。归脾;肾;膀胱经。清虚热;补肾;燥湿。主骨蒸潮热;腰膝酸软;头晕耳鸣;湿热腹泻;带下;淋浊。
白薇:别名白马尾。本品为萝藦科植物白薇或蔓生白薇的干燥根及根茎。苦、咸,寒。归胃、肝、肾经。清热凉血,利尿通淋,解毒疗疮。用于温邪伤营发热,阴虚发热,骨蒸劳热,产后血虚发热,热淋,血淋,痈疽肿毒。
结血蒿:别名普尔那(藏名)。为菊科植物毛莲蒿的全草。苦,寒。清虚热,健胃,驱风止痒。治瘟疫内热,四肢酸痛,骨蒸发烧。
山银柴胡:石竹科丝石竹属植物霞草、蚤缀属植物灯心蚤缀或蝇子草属植物旱麦瓶草的根。甘;性微寒。归肺;肝;胆;肾;胃经。凉血;清虚热。主阴虚肺劳;骨蒸潮热;盗汗;小儿疳热;久疟不止。
余甘子:别名滇橄榄、橄榄[云南.四川]、庵摩勒、油柑子。为大戟科油柑属植物余甘子,根、叶、树皮等亦可入药。甘、酸、涩、凉。清热凉血,消食健胃,生津止咳。用于血热血瘀,肝胆病,消化不良,腹痛,咳嗽,喉痛,口干。
刺梨根:别名茨藜子根(《天宝本草》),茨藜根(《贵阳民间药草》)。为蔷薇科植物刺梨的根。甘酸;平;无毒。归脾;胃;肝;肾经。健胃消食,止痛,收涩,止血。主胃脘胀满疼痛,牙痛,喉痛,久咳,泻痢,遗精,带下,崩漏,痔疮。
以下采用实施例来详细说明本发明的实施方式,借此对本发明如何应用技术手段来解决技术问题,并达成技术效果的实现过程能充分理解并据以实施。
实施例1中药添加剂
取白刺花13重量份、翼首草14重量份、水柏枝17重量份、瓶尔小草15重量份、蜈蚣萍11重量份、虾子花16重量份、岩椒草14重量份、寒莓根18重量份、大蛇药10重量份、薅田藨根12重量份、繁缕13重量份、地龙15重量份、崖棕根11重量份、铰剪藤18重量份、刺五加32重量份、红芪29重量份、升麻13重量份、手参13重量份、蕤仁12重量份、知母16重量份、秦艽21重量份、功劳子11 重量份、白薇16重量份、结血蒿17重量份、山银柴胡14重量份、余甘子18重量份和刺梨根9重量份。
制备方法包括以下步骤:
第一步,将所述各原料药材按比例混合,加入相对于混合物质量2倍的醇浓度为95%的乙醇,加热回流2小时,提取,过滤获得第一提取液;过滤获得的药渣再加入相对于所述药渣质量1倍的醇浓度为95%的乙醇,加热回流2小时,提取,过滤获得第二提取液;将第一提取液和第二提取液合并,减压浓缩除去乙醇溶剂,干燥,获得干膏;
第二步,将第一步获得的干膏放置在超微粉碎机中粉碎1小时,粉碎,过筛,获得300目的超微细粉,获得中药添加剂散剂。
实施例2饲料
本发明实施例提供了一种母猪产后配合饲料,饲料中各原料的重量份数为:玉米60重量份、小麦15重量份、小米50重量份、DDGS 12重量份、麦麸28重量份、西瓜皮渣20重量份、橄榄渣22重量份、海带15重量份、甘蔗汁18重量份、马齿苋25重量份、青稞粉16重量份、白扁豆18重量份、青椒渣17重量份、红薯粉16重量份、黑木耳19重量份、猕猴桃汁13重量份、玉米油5重量份、食盐3重量份、维生素预混料0.4重量份和微量元素预混料0.3重量份。
其制备方法包括以下步骤:
(1)破碎步骤:按重量份数比称取玉米、小麦、小米、DDGS、麦麸、西瓜皮渣、橄榄渣、海带、马齿苋、白扁豆、青椒渣和黑木耳,投入粉碎机进行微粉碎,经过粉碎后过2.0mm筛;
(2)配料步骤:按照重量份数比称取甘蔗汁、青稞粉、红薯粉、猕猴桃汁、玉米油、食盐、维生素预混料和微量元素预混料,与步骤(1)粉碎获得的细粉混合,投入混合机,混合均匀,混合时间为50s;
(3)制粒步骤:投入制粒机进行制粒,制粒温度为85℃,使其糊化度达到90%以上。
实施例3饲料
本发明实施例提供了一种母猪产后配合饲料,饲料中各原料的重量份数为:玉米60重量份、小麦15重量份、小米50重量份、DDGS 12 重量份、麦麸28重量份、西瓜皮渣20重量份、橄榄渣22重量份、海带15重量份、甘蔗汁18重量份、马齿苋25重量份、青稞粉16重量份、白扁豆18重量份、青椒渣17重量份、红薯粉16重量份、黑木耳19重量份、猕猴桃汁13重量份、玉米油5重量份、食盐3重量份、维生素预混料0.4重量份、微量元素预混料0.3重量份和中药添加剂3重量份;其中,中药添加剂为实施例1的中药添加剂散剂。
其制备方法包括以下步骤:
(1)破碎步骤:按重量份数比称取玉米、小麦、小米、DDGS、麦麸、西瓜皮渣、橄榄渣、海带、马齿苋、白扁豆、青椒渣和黑木耳,投入粉碎机进行微粉碎,经过粉碎后过2.0mm筛;
(2)配料步骤:按照重量份数比称取甘蔗汁、青稞粉、红薯粉、猕猴桃汁、玉米油、食盐、维生素预混料、微量元素预混料和中药添加剂,与步骤(1)粉碎获得的细粉混合,投入混合机,混合均匀,混合时间为50s;
(3)制粒步骤:投入制粒机进行制粒,制粒温度为85℃,使其糊化度达到90%以上。
中药添加剂的毒性试验:
1、试验药物
选取白刺花13g、翼首草14g、水柏枝17g、瓶尔小草15g、蜈蚣萍11g、虾子花16g、岩椒草14g、寒莓根18g、大蛇药10g、薅田藨根12g、繁缕13g、地龙15g、崖棕根11g、铰剪藤18g、刺五加32g、红芪29g、升麻13g、手参13g、蕤仁12g、知母16g、秦艽21g、功劳子11g、白薇16g、结血蒿17g、山银柴胡14g、余甘子18g和刺梨根9g混合,粉碎成粉末;将获得粉末加入1400g冷水中浸泡25小时,以文火煎煮,煎煮时间为1.5小时,将煎煮液过滤,获得第一滤液,收集滤渣;将过滤获得的滤渣再次加入1400g冷水中,以文火煎煮3次,每次煎煮1小时,过滤并合并过滤液,获得第二滤液;合并两次滤液,减压浓缩除去部分水,获得汤剂,汤剂的生药浓度为3g/ml。
2、试验方法:选用SD大鼠,给予不同浓度(18.0、6.0、2.0g 生药/kg)的本发明的中药添加剂的汤剂,每天灌胃一次,连续90天,末次给药后24小时各组活杀1/2动物(雌雄各半),其余1/2动物继续观察2周后活杀。试验期间观察动物的外观、一般行为、摄食量、体重变化,给药后90天和停药2周进行血液学(RBC、HB、网织红细胞、PLT、CT、WBC及分类)和血液生化(AST、ALT、ALP、Glu、BUN、Crca、TP、T.BIL、ALB、CHOL)、尿液生化、脏器系数、病理组织学等指标检查。试验结果表明:本发明的中药添加剂在高、中、低剂量组动物一般状态良好,外观体征、行为活动、进食量和体重增长均无异常变化;三个剂量组及对照组血液学检查、血液生化学、尿液生化检查均在正常范围,组间无显著差异;各组主要脏器组织病理学检查未见明显异常。上述指标停药2周后也未见改变。本试验用药剂量分别为临床用药剂量的180、60、20倍,根据试验结果本发明的中药制剂在高、中、低三个剂量(18.0、6.0、2.0g生药/kg)连续90天给药对大鼠无明显影响,无明确的毒性靶器官和敏感指标,恢复期观察也未见延迟性毒性反应,提示本发明的中药制剂临床应用的剂量安全性较高。
对比试验
江苏省兽医站2011年3月-2014年12月收治产后发热的病猪296例,表现为母猪发烧最高温度41℃左右、食欲减退,阴道中有脓性分泌物流出,泌乳减少,有3头猪死亡。取150头患病猪随机分成三组,分别为实施例组1、实施例组2和对照组,三组的患病猪在体重、病情等方面均无显著差异,具有可比性。实施例组1使用本发明实施例2的饲料饲喂,实施例组2使用实施例3的饲料饲喂、对照组使用传统饲料和传统药物进行治疗;其中,对照组中传统药物为使用青霉素,每千克体重5-8万单位,每日2次,饲喂传统饲料。结果如表1和表2所示。其中,痊愈:体温正常,精神食欲正常,阴道分泌物正常,正常泌乳;无效:临床症状没有改善甚至加重。
表1三实验组病猪的效果对照表
组别 总数 痊愈数 无效数 痊愈率
实施例组1 50头 48头 2头 96%
实施例组2 50头 50头 0头 100%
对照组 50头 42头 8头 84%
从表1数据可知:与传统药物相比,本发明实施例2和实施例3的饲料在治疗母猪产后发热方面具有疗效显著、价格低廉、无毒副作用的优势。
表2三实验组病猪痊愈平均时间表
Figure PCTCN2016084894-appb-000001
从表2数据可知:与对照组相比,使用本发明饲料治疗患病猪,病猪痊愈平均时间明显缩短。
通过对比试验可知:与传统药物相比,本发明实施例2和实施例3的饲料在治疗母猪产后发热方面具有毒副作用小、疗效显著、能够满足病猪的营养需求的优势。
典型病例
江苏南京某农户2012年7月一母猪产后发热,母猪发烧最高温度41℃、阴道中有脓性分泌物流出,食欲减退,经检查确诊为母猪产后发热,使用本发明实施例3的饲料加入7倍的温水搅拌成糊状给病猪服用,1小时后体温正常,4小时后食欲恢复,8小时后阴道中脓性分泌物明显减少,12小时后痊愈。三月后回访未复发。
江苏徐州某农户2014年2月一母猪产后发热,母猪发烧最高温度41℃、食欲减退,泌乳减少严重影响仔猪的发育,导致4头仔猪死亡,经检查确诊为母猪产后发热,使用本发明实施例2的饲料加入8倍的温水搅拌成糊状饲喂;7小时后母猪体温正常,12小时后食欲恢复,泌乳量增加,24小时后痊愈。三月后回访未复发。
以上所述仅为本发明的较佳实施例,并不用以限制本发明,凡在本发明的精神和原则之内,所作的任何修改、等同替换、改进等,均应包含在本发明的保护范围之内。

Claims (9)

  1. 母猪产后配合饲料,其特征在于,所述饲料包括以下原料:玉米、小麦、小米、DDGS、麦麸、西瓜皮渣、橄榄渣、海带、甘蔗汁、马齿苋、青稞粉、白扁豆、青椒渣、红薯粉、黑木耳、猕猴桃汁、玉米油、食盐、维生素预混料和微量元素预混料。
  2. 根据权利要求1所述的母猪产后配合饲料,其特征在于,所述饲料中各原料的重量份数为:玉米40-80重量份、小麦10-20重量份、小米45-60重量份、DDGS 10-15重量份、麦麸20-30重量份、西瓜皮渣15-25重量份、橄榄渣10-30重量份、海带10-20重量份、甘蔗汁10-20重量份、马齿苋10-30重量份、青稞粉15-20重量份、白扁豆15-20重量份、青椒渣15-20重量份、红薯粉15-20重量份、黑木耳15-20重量份、猕猴桃汁10-15重量份、玉米油2-6重量份、食盐2-4重量份、维生素预混料0.1-0.5重量份和微量元素预混料0.1-0.5重量份。
  3. 根据权利要求1或2所述的母猪产后配合饲料,其特征在于,所述饲料还包括中药添加剂,所述饲料中各原料的重量份数为:玉米40-80重量份、小麦10-20重量份、小米45-60重量份、DDGS 10-15重量份、麦麸20-30重量份、西瓜皮渣15-25重量份、橄榄渣10-30重量份、海带10-20重量份、甘蔗汁10-20重量份、马齿苋10-30重量份、青稞粉15-20重量份、白扁豆15-20重量份、青椒渣15-20重量份、红薯粉15-20重量份、黑木耳15-20重量份、猕猴桃汁10-15重量份、玉米油2-6重量份、食盐2-4重量份、维生素预混料0.1-0.5重量份、微量元素预混料0.1-0.5重量份和中药添加剂1-3重量份。
  4. 根据权利要求1-3任一项所述的母猪产后配合饲料,其特征在于,所述饲料中各原料的重量份数为:玉米60重量份、小麦15重量份、小米50重量份、DDGS 12重量份、麦麸28重量份、西瓜皮渣20重量份、橄榄渣22重量份、海带15重量份、甘蔗汁18重量份、马齿苋25重量份、青稞粉16重量份、白扁豆18重量份、青椒渣17 重量份、红薯粉16重量份、黑木耳19重量份、猕猴桃汁13重量份、玉米油5重量份、食盐3重量份、维生素预混料0.4重量份、微量元素预混料0.3重量份和中药添加剂3重量份。
  5. 根据权利要求1-4任一项所述的母猪产后配合饲料,其特征在于,所述中药添加剂包括以下原料药材:白刺花、翼首草、水柏枝、瓶尔小草、蜈蚣萍、虾子花、岩椒草、寒莓根、大蛇药、薅田藨根、繁缕、地龙、崖棕根、铰剪藤、刺五加、红芪、升麻、手参、蕤仁、知母、秦艽、功劳子、白薇、结血蒿、山银柴胡、余甘子和刺梨根。
  6. 根据权利要求1-5任一项所述的母猪产后配合饲料,其特征在于,所述中药添加剂中各原料药材的重量份数为:白刺花11-17重量份、翼首草10-16重量份、水柏枝12-20重量份、瓶尔小草12-20重量份、蜈蚣萍9-18重量份、虾子花12-18重量份、岩椒草10-19重量份、寒莓根12-19重量份、大蛇药10-15重量份、薅田藨根10-18重量份、繁缕10-17重量份、地龙10-15重量份、崖棕根10-18重量份、铰剪藤14-25重量份、刺五加25-38重量份、红芪22-33重量份、升麻9-15重量份、手参12-19重量份、蕤仁12-19重量份、知母12-19重量份、秦艽15-25重量份、功劳子10-14重量份、白薇12-19重量份、结血蒿10-18重量份、山银柴胡10-18重量份、余甘子12-21重量份和刺梨根8-15重量份。
  7. 根据权利要求1-6任一项所述的母猪产后配合饲料,其特征在于,所述中药添加剂中各原料药材的重量份数为:白刺花13重量份、翼首草14重量份、水柏枝17重量份、瓶尔小草15重量份、蜈蚣萍11重量份、虾子花16重量份、岩椒草14重量份、寒莓根18重量份、大蛇药10重量份、薅田藨根12重量份、繁缕13重量份、地龙15重量份、崖棕根11重量份、铰剪藤18重量份、刺五加32重量份、红芪29重量份、升麻13重量份、手参13重量份、蕤仁12重量份、知母16重量份、秦艽21重量份、功劳子11重量份、白薇16重量份、结血蒿17重量份、山银柴胡14重量份、余甘子18重量份和刺梨根9重量份。
  8. 根据权利要求1-7任一项所述的母猪产后配合饲料,其特征 在于,所述中药添加剂的制备方法包括以下步骤:
    第一步,将所述各原料药材按比例混合,加入相对于混合物质量2~4倍的醇浓度为85~95%的乙醇,加热回流1~3小时,提取,过滤获得第一提取液;过滤获得的药渣再加入相对于所述药渣质量1~2倍的醇浓度为85~95%的乙醇,加热回流1~3小时,提取,过滤获得第二提取液;将第一提取液和第二提取液合并,减压浓缩除去乙醇溶剂,干燥,获得干膏;
    第二步,将第一步获得的干膏放置在超微粉碎机中粉碎1~2小时,粉碎,过筛,获得300目~400目的超微细粉,获得中药添加剂散剂。
  9. 根据权利要求1-8任一项所述的母猪产后配合饲料的制备方法,其特征在于,所述制备方法包括以下步骤:
    (1)破碎步骤:按重量份数比称取玉米、小麦、小米、DDGS、麦麸、西瓜皮渣、橄榄渣、海带、马齿苋、白扁豆、青椒渣和黑木耳,投入粉碎机进行微粉碎,经过粉碎后过2.0mm筛;
    (2)配料步骤:按照重量份数比称取甘蔗汁、青稞粉、红薯粉、猕猴桃汁、玉米油、食盐、维生素预混料、微量元素预混料和中药添加剂,与步骤(1)粉碎获得的细粉混合,投入混合机,混合均匀,混合时间为30-60s;
    (3)制粒步骤:投入制粒机进行制粒,制粒温度为85℃,使其糊化度达到90%以上。
PCT/CN2016/084894 2015-06-17 2016-06-06 母猪产后配合饲料及其制备方法 WO2016202184A1 (zh)

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