WO2016180087A1 - 便携式全自动生化分析装置 - Google Patents

便携式全自动生化分析装置 Download PDF

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Publication number
WO2016180087A1
WO2016180087A1 PCT/CN2016/076987 CN2016076987W WO2016180087A1 WO 2016180087 A1 WO2016180087 A1 WO 2016180087A1 CN 2016076987 W CN2016076987 W CN 2016076987W WO 2016180087 A1 WO2016180087 A1 WO 2016180087A1
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Prior art keywords
locking
chip
groove
detection
ratchet
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PCT/CN2016/076987
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English (en)
French (fr)
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王战会
裴臣超
朱焱
江伟
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天津微纳芯科技有限公司
微纳芯（北京）科技有限公司
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Publication of WO2016180087A1 publication Critical patent/WO2016180087A1/zh

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor

Definitions

  • the invention relates to the field of biochemical detection, in particular to a portable biochemical detection device for microfluidic chip detection.
  • ⁇ -TAS Miniaturized Total Analysis Systems
  • the microfluidic chip can integrate chemical or biological laboratories on a few square centimeters of chips for sample pretreatment, separation and detection. Through the high integration and miniaturization of chemical equipment, the analytical laboratory can be maximized. The function is transferred to a portable device. At this stage, it has been widely used in many fields such as biology, drug diagnosis, genetic analysis, environmental monitoring, etc. At the same time, due to its small, portable and convenient advantages, microfluidic chips have also shown superior advantages in the field of clinical medicine. The microfluidic chip can realize "Point of Care" (POC), which is of great significance to global public health.
  • POC Point of Care
  • detection devices based on microfluidic chips mainly include optical detection (such as fluorescence, absorbance, chemiluminescence, plasma resonance, etc.), electrochemical detection (such as ampere, potential, conductance, etc.) and mass spectrometry, etc., and these devices are usually Large volume, mainly used for experimental research, not suitable for carrying, can not meet the needs of doctors to carry out, how to optimize the structure of portable detection device to make it real It is important to carry it around and make it a member of the doctor's medical kit.
  • optical detection such as fluorescence, absorbance, chemiluminescence, plasma resonance, etc.
  • electrochemical detection such as ampere, potential, conductance, etc.
  • mass spectrometry etc.
  • the prior art JP-A-2006-110491 discloses a microchip rotating device which performs centrifugation by applying a centrifugal force to a microchip that is introduced into a blood of a subject, and uniformly mixes the plasma and the reagent after centrifugation as a detection target.
  • the liquid is further introduced into a centrifugal separator for a microchip of the absorptive photometric unit.
  • the prior art CN200710126374.8 discloses a microchip inspection device which can be used for blood analysis and which can combine the centrifugation and detection steps in one chip, however the inspection device chip placement portion is only suitable for a single-channel chip of a specific shape. Detected, and the chip is placed around both sides of the rotor shaft, which makes the detection device increase in volume and is not suitable for multi-channel rapid detection.
  • the prior art CN201120521940.7 discloses a motor assembly capable of fixing, arranging and driving the rotation of a circular biochip, which can realize the triviality of a circular chip, which can be used for a microchip detecting device, however
  • the trivial mechanism includes a locking shaft, a locking cam structure and a complicated external auxiliary structure, and the structure is complicated and large, resulting in poor portability of the entire inspection device.
  • the invention provides a portable automatic biochemical analysis device for overcoming the shortcomings of poor portability, complicated structure and low detection efficiency of the prior art microfluidic chip detecting device.
  • the present invention adopts the following technical solutions:
  • a portable automatic biochemical analysis device comprising: a housing, a power source, a control module and a core module;
  • the core module comprises: a chip provided with at least one detecting slot, capable of entering and leaving the chip holding portion of the housing, and setting Fixed on the chip holder And a locking device for locking the chip, a rotation driving portion for rotating the chip, a light source portion for illuminating the light in the chip detecting groove, and a detecting portion for receiving light passing through the detecting groove; wherein the rotating driving portion
  • the light source unit and the detecting unit are respectively connected to the control module.
  • control module is disposed above the interior of the housing; the power source and the core module are disposed below the interior of the housing.
  • the control module can be a main control card, and the power source can be a battery.
  • the chip holding portion includes an entrance and exit bin and a transmission gear; and the access frame is provided with a through hole for accommodating the chip locking device.
  • the transmission gear is located inside the access bin and is driven by the internal gear transmission.
  • the rotary driving part is a motor, and the motor drives the motor shaft to rotate to drive the chip to rotate. More preferably, the motor is a DC brushless motor.
  • the center of the lower surface of the chip comprises a circular groove, and the circular groove is provided with at least one positioning block and at least one locking hole in the circumferential direction. More preferably, the chip is circular, and the detection grooves are plural and uniformly disposed along the circumferential direction of the chip.
  • the locking device comprises a rotating tray and a locking disc fixed above the rotating tray, the rotating tray is coaxial with the locking disc, and the rotating tray has a larger diameter than the locking disc;
  • the locking disc is circumferentially provided with at least one positioning groove and at least one locking member; the positioning groove is disposed outside the locking disc, and is used together with the positioning block of the chip for preventing the chip A circumferential movement occurs between the locking disc and the locking disc;
  • the locking member comprises a spring-loaded locking piece, the spring is located in a locking cavity inside the locking disc, and the locking piece can be extended and locked Cavity, used in conjunction with the locking hole of the chip, to prevent the chip Axial movement.
  • the locking piece may be a regular or irregular shape or a hook shape, the locking piece may have a certain thickness, and in some cases may be expressed as a spherical or block-shaped convex shape.
  • the rotating tray is provided with an anti-slip mat.
  • the number of the positioning groove and the locking member are 2-10, respectively, and more preferably, the number of the positioning groove and the locking member is 3-6, for example, 3, 4, 5 , six.
  • the positioning groove and the locking member are evenly disposed along the circumferential direction of the locking disk and are spaced apart from each other.
  • the locking device further comprises a locking connection seat, the locking connection seat being located below the rotating tray.
  • the locking joint and the rotating tray may be an integral structure or separate components. When the two are independent components, they may be locked by fasteners such as bolts or the like.
  • the locking connector is fixed to the rotary driving portion by a top wire.
  • the rotating driving portion drives the locking connecting seat to rotate to drive the rotating tray to rotate.
  • the locking device further comprises a ratchet rotation preventing mechanism
  • the ratchet rotation preventing mechanism comprises a ratchet wheel with a ratchet groove, a V-shaped pawl, a rotation preventing spring and a positioning pin; wherein the ratchet wheel is arranged in the locking connection Below the seat, the rotation preventing spring and the positioning pin are respectively disposed on the chip holding portion, and the claw of the V-shaped pawl can protrude into the ratchet groove by the elastic force of the rotation preventing spring, the V-shaped pawl
  • the claw head 2 is connected to the positioning pin, and the positioning pin can drive the claw head to leave the ratchet groove.
  • the components of the biochemical analysis device of the invention are compact in structure and pass through The reasonable layout of the various components greatly reduces the size of the device, enabling it to truly achieve on-site analysis.
  • the internal gear transmission method reduces the volume in the width direction of the loading and unloading frame; the ingenious design of the locking structure and the chip also saves space and further reduces the volume of the device.
  • the chip can be automated from separation to detection. It only needs to add the components to be tested into the chip. In the analysis device, the separation can be quickly performed and the indicators can be detected, which greatly improves the detection efficiency.
  • Figure 1 is a schematic structural view of the biochemical analysis device of the present invention
  • FIG. 2 is a layout diagram of various components of the biochemical analysis device of the present invention.
  • FIG. 3 is a schematic view of the biochemical analysis device chip holding portion of the present invention located outside the casing
  • Figure 4 is a schematic view showing the positional relationship of various components of the biochemical analysis device of the present invention
  • Figure 5 is a schematic view of the chip structure of the present invention
  • Figure 6 is a schematic view showing the structure of the chip holding portion of the present invention.
  • Figure 7 is a schematic view showing the structure of the locking device of the present invention.
  • Figure 8 is a schematic cross-sectional view of the locking device of the present invention
  • Figure 9 is a schematic view showing the structure of the locking device with the motor of the present invention.
  • Figure 10 is a schematic view showing the structure of the locking device after mounting the chip of the present invention
  • Figure 11 is a schematic view showing the structure of the ratchet rotation preventing mechanism of the present invention
  • the portable automatic biochemical analysis device 1 of the present invention includes a housing The power module 20, the control module 30, and the core module 40.
  • the core module 40 includes: a chip 100 provided with at least one detecting slot, a chip holding portion 200 capable of entering and exiting the housing, and a fixing portion disposed on the chip holding portion for fixing And a locking device 300 for locking the chip, a rotation driving portion 400 for rotating the chip, and a light source portion 500 for illuminating the light in the chip detecting groove for receiving the detecting portion 600 that transmits the light passing through the detecting groove; wherein, the rotating portion
  • the driving unit 400, the light source unit 500, and the detecting unit 600 are communicably connected to the control module 30, respectively.
  • the liquid to be tested is added to the chip 100, and then the chip holding portion 200 is ejected inside the casing 10.
  • the chip 100 is placed in the chip holding portion 200, and the chip is locked by the locking device 300.
  • the chip holding portion 200 enters the inside of the casing, and the rotation of the rotating driving portion is controlled by the control module, thereby driving the chip to rotate, and the liquid to be tested in the chip is separated by the centrifugal force, and enters the detecting groove to control the rotation driving portion to stop.
  • Rotating, controlling the light source portion to emit a certain wavelength of detection light the detection light is transmitted through the detection liquid in the detection tank, and is received by the detecting portion, and the data is transmitted to the control module.
  • a display screen 50 is disposed outside the housing 10.
  • the power source 20 can be a battery that is disposed inside the housing to meet the needs of portable access.
  • the control module 30 can be a main control board for controlling the rotation driving part to drive the chip to rotate or stop, controlling the light source part to emit a wave of a certain wavelength into the chip detection slot, collecting the detection data sent by the detecting part, and performing analysis processing.
  • the position layout of each component of the analysis device is optimized.
  • the control module 30 is disposed above the interior of the housing 10;
  • the power source 20 and the core module 40 are disposed in the shell Below the inside of the body.
  • the wire harness connecting the core module 40 and the control module 30 is reduced in size in the width direction of the analyzing device by the vertical layout.
  • the control module and the core module are communicatively connected through the connector 60 and the wire harness 70.
  • the chip 100 may be a circular chip, and the center of the lower surface of the chip 100 includes a circular groove 110, and the shape of the groove 110 matches the locking device 300;
  • the groove 110 is disposed in the axial direction with at least one positioning block 120 and a locking hole.
  • the chip 100 in order to improve the detection efficiency, realize multi-index, multi-function, multi-sample high-throughput detection, the chip 100 is uniformly disposed with a plurality of detecting slots 140 in the circumferential direction, and the number of detecting slots can be performed according to actual needs. Select.
  • the circular chip may be a multi-layer chip including a liquid inlet tank, a liquid storage tank, and a plurality of detection grooves, such as the chip structure shown in the prior art CN201110416978.2, CN201110086070.X, CN201210046040.0.
  • the chip holding portion 200 includes an access frame 210 and a transmission gear 220.
  • the access frame 210 is provided with a through hole 211 for receiving the chip locking device 300.
  • the invention is provided with an inlet and outlet structure capable of freely entering and exiting the inside of the casing, and is convenient for installation and replacement of the chip in the outbound state. After entering the warehouse, the chip can be ensured to be in a dark environment during detection, thereby avoiding external stray light interference detection.
  • the driving gear 220 is disposed inside the loading and unloading frame 210, and is internally driven with the gears located outside the loading and unloading frame to realize the loading and unloading of the chip.
  • a locking device 300 for locking a chip includes a rotating tray 310 and a locking circle fixed above the rotating tray 310.
  • the disk 320, the rotating tray 310 is coaxial with the locking disk 320, and the rotating tray 310 has a larger diameter than the locking disk 320.
  • the rotating tray 310 and the locking disc 320 can be of unitary construction or can be assembled by separate components (integral construction shown in Figure 5).
  • the rotating tray 310 is used to mount the chip 100.
  • the chip may be a circular chip.
  • the center of the lower surface of the chip 100 includes a circular groove 110.
  • the shape of the groove 110 matches the locking disk 320.
  • the groove 110 of the chip 100 is aligned with the locking disk 320 and pressed downward.
  • the outer side of the lower surface of the chip 100 is in contact with the rotating tray.
  • the locking disc 320 is circumferentially provided with at least one locating recess 321 and at least one locking member 322 (three shown in the drawings).
  • the number of the positioning groove 321 and the locking member 322 is 2-10, and the number of the positioning groove 321 and the locking member 322 can be selected according to actual requirements.
  • the number of the positioning groove 321 and the locking member 322 can be specifically 3. -6, for example 3, 4, 5, 6.
  • the positioning groove 321 and the locking member 322 are uniformly disposed circumferentially along the locking disc 320 and are spaced apart from each other.
  • the positioning recess 321 is disposed outside the locking disc 320 for use with the positioning block 120 of the chip 100 for preventing circumferential movement between the chip 100 and the locking disc 320.
  • the shape of the positioning groove 321 coincides with the chip positioning block 120, and the positioning block 120 can be caught in the positioning groove 321, and the chip 100 is restricted from moving on the XY plane.
  • the locking member 322 includes a locking tab 324 with a spring 323.
  • the spring 322 is located in the locking cavity 325 inside the locking disc 320.
  • the locking piece 325 can extend out of the locking cavity 325 under the elastic force of the spring 323 to cooperate with the locking hole of the chip 100 for preventing the chip. Axial movement. When the chip is placed, the chip is pressed down, the locking piece 323 is retracted into the locking cavity 325, and the downward pressing is continued.
  • the locking piece 323 is ejected into the locking hole of the chip 100 under the elastic force, and passes through the lateral direction of the spring.
  • the spring force locks the chip to prevent the chip from popping up at high speeds.
  • the locking piece may be a regular or irregular shape or a hook shape
  • the locking piece may have a certain thickness, and in some cases may be expressed as a spherical or block-shaped convex shape.
  • an anti-slip mat 311 is disposed on the upper surface of the rotating tray, and is non-slip when the chip 100 is placed on the rotating tray 310.
  • the friction between the pad and the chip is increased to further improve the locking effect.
  • the rotary driving unit 400 of the present invention may be a motor 410 for driving the rotating tray 310 to rotate, and then driving the chip 100 fixed thereon to rotate.
  • the motor can be a DC brushless motor or other conventional motors in the field.
  • the locking device 300 of the present invention may further include a locking joint 330, which is located below the rotating tray 310 and disposed coaxially.
  • the locking joint 330 and the rotating tray 310 may be an integral structure or separate components. When the two are independent components, they may be locked by fasteners such as bolts (the drawings are independent of each other) Parts).
  • the locking joint 330 is secured to the motor shaft 420 of the motor 410 by a top wire 331.
  • the motor drives the locking connection 330 to rotate, which in turn drives the rotating tray 310 to rotate, which in turn drives the chip to rotate.
  • the locking device 300 of the present invention in order to avoid the rotation of the rotating tray during the process of placing the chip, the locking difficulty is increased, and the locking device 300 of the present invention can be provided with the ratchet rotation preventing mechanism 340.
  • the ratchet rotation preventing mechanism 340 is disposed below the locking coupling 330, and includes a ratchet 342 with a ratchet groove 341, a V-shaped pawl 343, a rotation preventing spring 344, and a positioning pin 345.
  • the claw head 346 of the V-shaped pawl 343 can extend into the ratchet groove 341 by the elastic force of the rotation preventing spring 344, and the claw head 347 of the V-shaped pawl 343 is connected with the positioning pin 345, and the positioning pin 345 can be
  • the pawl head 347 is depressed, which in turn causes the pawl head 346 to exit the ratchet slot 341.
  • the ratchet groove stops, so that the locking connection block stops rotating, and then the rotating tray is stopped; when the claw head leaves the ratchet groove, the motor can be started to drive the rotating tray to rotate.
  • the anti-rotation spring 344 and the positioning pin 345 can be fixed in the access bin 210 of the inspection device.
  • the anti-rotation spring 344 When in the out-of-stock state, the anti-rotation spring 344 is ejected, and the claw-346 is pressed under the elastic force.
  • the positioning pin 345 acts to press the pawl 2347 downward, and then the pawl 346 is moved away from the ratchet groove 341.

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Abstract

一种便携式全自动生化分析装置（1），包括壳体（10）、电源（20）、控制模块（30）和核心模块（40）；核心模块（40）包括：设置有至少一个检测槽（140）的芯片（100），能够进出壳体（10）的芯片保持部（200），设置在芯片保持部（200）上的用于固定和锁紧芯片（100）的锁紧装置（300），用于使芯片（100）旋转的旋转驱动部（400），将光照射在芯片（100）的检测槽（140）中的光源部（500），用于接受透过检测槽（140）的光的探测部（600）；其中，所述旋转驱动部（400）、光源部（500）和探测部（600）分别与控制模块（30）通讯连接。全自动生化分析装置（1）能够用于微流控芯片（100）的检测，体积小、便携，适于现场即时检测，且芯片（100）从分离到检测可以实现自动化，检测效率高。

Description

便携式全自动生化分析装置 技术领域
本发明涉及生化检测领域，特别涉及一种用于微流控芯片检测的便携式生化检测装置。
背景技术
20世纪90年代初，Manz和Widmer等提出了微流控芯片实验室(lab-on-a-chip)的概念，也称为微全分析系统(Miniaturized Total Analysis Systems，μ-TAS)。微流控芯片能够将化学或生物实验室集成在几平方厘米的芯片上，进行样品预处理、分离以及检测等，通过对化学设备的高度集成化与微型化，最大限度的将分析实验室的功能转移到便携的设备中。现阶段，其已广泛应用于生物学、药物诊断、基因分析、环境监测等众多领域；同时，因其小型、便携、方便的优点，微流控芯片在临床医学领域也显现出卓越的优势，使微流控芯片可以实现“现场即时检测”(Point of care，POC)，对全球公共健康具有重要意义。
微流控芯片的快速发展一方面给现场即时检测带来了新的契机，另一方面也对检测装置提出了更高的要求。目前，基于微流控芯片的检测装置主要包括光学检测(如荧光、吸光度、化学发光、等离子体谐振等)、电化学检测(如安培、电位、电导等)及质谱检测等，而这些装置通常体积较大，主要用于实验研究，不宜携带，不能满足医生出诊携带的需求，如何优化便携式检测装置的结构使其真正的实现 随身携带、使其成为医生出诊医疗包内的一员具有重要的意义。
目前，现有技术JP-特开-2006-110491公开了一种微型芯片旋转装置，通过给导入待检体血液的微型芯片施加离心力进行离心分离，将离心后的血浆和试剂混合均匀作为检测对象液，再导入到吸光光度测量部的微型芯片用离心分离装置。然而，其需要在离心后将芯片取出，再进行吸光光度分析，无法实现一体化、及时检测，影响检测效率。现有技术CN200710126374.8公开了一种微型芯片检查装置，可用于血液分析，并能够将离心和检测步骤集合在一个芯片中，然而该检查装置芯片载置部仅适用于特定形状的单通道芯片检测，且芯片围绕转子轴两侧设置，使检测装置体积增大，且不适用于多通道快速检测。现有技术CN201120521940.7公开了一种能够固定、琐紧和带动圆形生物芯片转动的电机组件，其能够实现对圆形芯片的琐止，该电机组件能够用于微芯片检测装置，然而其琐紧机构包括锁紧轴、锁紧凸轮结构和复杂的外部辅助结构，结构复杂、体积大，导致整个检查装置便携性差。
发明内容
本发明为克服现有技术微流控芯片检测装置便携性差、结构复杂、检测效率低等缺点，提供了一种便携式全自动生化分析装置。
为了实现本发明的目的，本发明采用如下技术方案：
一种便携式全自动生化分析装置，其特征在于：包括壳体、电源、控制模块和核心模块；所述核心模块包括：设置有至少一个检测槽的芯片，能够进出壳体的芯片保持部，设置在芯片保持部上的用于固定 和锁紧芯片的锁紧装置，用于使芯片旋转的旋转驱动部，将光照射在芯片检测槽中的光源部，用于接受透过检测槽光的探测部；其中，所述旋转驱动部、光源部和探测部分别与控制模块通讯连接。
优选的，所述控制模块设置在壳体内部上方；电源与核心模块设置在壳体内部下方。优选的，所述控制模块可为主控板卡，所述电源可为电池。
优选的，所述芯片保持部包括进出仓架和传动齿轮；所述进出仓架上设置一通孔，用于安放芯片锁紧装置。
优选的，所述传动齿轮位于进出仓架内侧，通过内齿传动方式进行传动。
优选的，所述旋转驱动部为电机，所述电机带动电机轴旋转进而带动芯片旋转。更优选的，所述电机为直流无刷电机。
优选的，所述芯片下表面中央包括一圆形凹槽，所述圆形凹槽沿周向设置有至少一个定位块和至少一个锁紧孔。更优选的，所述芯片为圆形，所述检测槽为多个且沿芯片周向均匀设置。
优选的，所述锁紧装置包括旋转托盘和固定在旋转托盘上方的锁紧圆盘，所述旋转托盘与锁紧圆盘同轴，且所述旋转托盘直径大于所述锁紧圆盘；其中，所述锁紧圆盘周向设置有至少一个定位凹槽和至少一个锁紧件；所述定位凹槽设置在所述锁紧圆盘外侧，与芯片的定位块配合使用，用于防止芯片与锁紧圆盘之间发生周向移动；所述锁紧件包括带弹簧的锁紧片，所述弹簧位于锁紧圆盘内部的锁紧腔中，所述锁紧片可伸出锁紧腔，与芯片的锁紧孔配合使用，用于防止芯片 轴向移动。其中锁紧片可为形状规则或不规则的片状或钩状，所述锁紧片可具有一定厚度，在某些情况下可表现为球形或块形凸起形状。
优选的，所述旋转托盘上设置有防滑垫。
优选的，所述定位凹槽和锁紧件的数量分别为2-10个，更优选的，所述所述定位凹槽和锁紧件的数量为3-6个，例如3，4，5，6个。
优选的，所述定位凹槽和锁紧件沿锁紧圆盘周向均匀设置，且相互间隔。
优选的，所述锁紧装置还包括锁紧连接座，所述锁紧连接座位于旋转托盘下方。所述锁紧连接座与旋转托盘可为一体结构，也可为相互独立的部件，当两者为相互独立的部件时，可通过紧固件如螺栓等锁紧。
优选的，所述锁紧连接座通过顶丝固定在所述旋转驱动部上。所述旋转驱动部带动锁紧连接座转动继而带动旋转托盘转动。
优选的，所述锁紧装置还包括棘轮止转机构，所述棘轮止转机构包括带棘轮槽的棘轮、V形棘爪、止转弹簧和定位销；其中，所述棘轮设置在锁紧连接座下方，所述止转弹簧和定位销分别设置在芯片保持部上，所述V形棘爪的爪头一在止转弹簧的弹力作用下可伸入棘轮槽中，所述V形棘爪的爪头二与定位销相连，定位销可带动爪头一离开棘轮槽。
本发明有益效果：
1.体积小、便携性好。本发明生化分析装置各部件结构紧凑，通 过各部件合理布局极大的缩小了装置的体积，使其能够真正实现现场即时分析。例如，采用内齿传动方式，缩小了进出仓架宽度方向的体积；锁紧结构和芯片的巧妙设计，也节省了空间，使装置体积进一步减小。
2.自动分析、高通量检测。芯片从分离到检测可以实现自动化，仅需要将待检组分加入芯片中，在分析装置中可快速进行分离、各指标检测，大大提高了检测效率。
附图说明
图1本发明生化分析装置结构示意图
图2本发明生化分析装置各部件布局图
图3本发明生化分析装置芯片保持部位于壳体外部示意图
图4本发明生化分析装置各部件位置关系示意图
图5本发明芯片结构示意图
图6本发明芯片保持部结构示意图
图7本发明锁紧装置结构示意图
图8本发明锁紧装置剖面示意图
图9本发明带电机的锁紧装置结构示意图
图10本发明安装芯片后的锁紧装置结构示意图
图11本发明棘轮止转机构结构示意图
具体实施方式
下面将结合附图，对本发明实施方式进行清楚、完整地描述。
参见附图1-2，本发明便携式全自动生化分析装置1，包括壳体 10、电源20、控制模块30和核心模块40；其中，核心模块40包括：设置有至少一个检测槽的芯片100，能够进出壳体的芯片保持部200，设置在芯片保持部上的用于固定和锁紧芯片的锁紧装置300，用于使芯片旋转的旋转驱动部400，将光照射在芯片检测槽中的光源部500，用于接受透过检测槽光的探测部600；其中，旋转驱动部400、光源部500和探测部600分别与控制模块30通讯连接。
在检测时，将待检液加入芯片100中，然后使芯片保持部200弹出壳体10内部，参见附图3，将芯片100放入芯片保持部200中，通过锁紧装置300锁紧芯片，再使芯片保持部200进入壳体内部，通过控制模块控制旋转驱动部转动，从而带动芯片发生转动，芯片中的待检液在离心力的作用下分离，并进入检测槽中，控制旋转驱动部停止转动，控制光源部发出一定波长的检测光，检测光透过检测槽中的待检液后由探测部接收，并将数据传输至控制模块。
在一个具体的实施方式中，参见附图3，壳体10外侧设置有显示屏50。
在一个具体的实施方式中，电源20可为电池，设置在壳体内部，可满足便携出诊的需求。控制模块30可为主控板卡，用于控制旋转驱动部带动芯片旋转或停止、控制光源部向芯片检测槽中发射一定波长的波、收集探测部发送的检测数据，并进行分析处理。
在一个具体的实施方式中，为了尽可能减小分析装置的体积，使其更便携，对分析装置各部件的位置布局进行优化，参见附图4，控制模块30设置在壳体10内部上方；电源20与核心模块40设置在壳 体内部下方。连接核心模块40和控制模块30之间的线束通过纵向布局，减小了分析装置宽度方向上的尺寸。具体的，控制模块与核心模块通过连接器60和线束70通讯连接。
参见附图5，在本发明一具体实施方式中，芯片100可为圆形芯片，芯片100下表面中央包括一圆形凹槽110，凹槽110的形状与锁紧装置300匹配；在圆形凹槽110的轴向设置有至少一个定位块120和锁紧孔。在一个具体的实施方式中，为了提高检测效率、实现多指标、多功能、多样品的高通量检测，芯片100周向均匀设置有多个检测槽140，检测槽的数量可根据实际需求进行选取。更具体的，该圆形芯片可为包括进液槽、储液槽、多个检测槽的多层芯片，例如现有技术CN201110416978.2、CN201110086070.X、CN201210046040.0所示的芯片结构。
参见附图6，在本发明一具体实施方式中，芯片保持部200包括进出仓架210和传动齿轮220；其中，进出仓架210上设置一通孔211，用于安放芯片锁紧装置300。本发明通过设置能够自由进出壳体内部的进出仓结构，在出仓状态下，便于安装和更换芯片，在进仓后，能够保证芯片在检测时处于黑暗环境中，避免外界杂散光干扰检测。进一步地，本发明为了减小芯片保持部的尺寸，将传动齿轮220设置在进出仓架210内侧，与位于进出仓架外侧的齿轮进行内齿传动，实现芯片的进仓和出仓。
参见附图7-8，在本发明一具体实施方式中，用于锁紧芯片的锁紧装置300，包括旋转托盘310和固定在旋转托盘310上方的锁紧圆 盘320，旋转托盘310与锁紧圆盘320同轴，且旋转托盘310直径大于锁紧圆盘320。在一个具体的实施方式中，旋转托盘310和锁紧圆盘320可为一体结构，也可通过独立部件组装(附图5中所示为一体结构)。
其中，旋转托盘310用于安放芯片100，参见附图5，芯片可为圆形芯片，芯片100下表面中央包括一圆形凹槽110，凹槽110的形状与锁紧圆盘320匹配，在安放芯片时，将芯片100的凹槽110与锁紧圆盘320对准，向下压动。芯片100下表面圆环外侧与旋转托盘相接触。
参见附图7-8，锁紧圆盘320周向设置有至少一个定位凹槽321和至少一个锁紧件322(附图所示为3个)。在一个具体的实施方式中，定位凹槽321和锁紧件322的数量为2-10个，其数量可以根据实际需求进行选取，定位凹槽321和锁紧件322的数量具体的可为3-6个，例如3，4，5，6个。
为了保证锁紧力均匀，定位凹槽321和锁紧件322沿锁紧圆盘320周向均匀设置，且相互间隔布置。
参见附图5，7-8，定位凹槽321设置在锁紧圆盘320外侧，与芯片100的定位块120配合使用，用于防止芯片100与锁紧圆盘320之间发生周向移动。在实际应用中定位凹槽321的形状与芯片定位块120相吻合，定位块120可卡在定位凹槽321中，限制芯片100在XY面发生移动。
参见附图5，7-8，锁紧件322包括带弹簧323的锁紧片324，其 中，弹簧322位于锁紧圆盘320内部的锁紧腔325中，锁紧片325在弹簧323弹力作用下可伸出锁紧腔325，与芯片100的锁紧孔配合使用，用于防止芯片轴向移动。在安放芯片时，向下按压芯片，锁紧片323缩回锁紧腔325中，继续向下按动，锁紧片323在弹力作用下弹出进入芯片100的锁紧孔中，通过弹簧的横向弹簧力锁紧芯片，防止芯片在高速转动时弹出。其中锁紧片可为形状规则或不规则的片状或钩状，所述锁紧片可具有一定厚度，在某些情况下可表现为球形或块形凸起形状。
在本发明一个具体的实施方式中，参见附图8，为了防止芯片100和旋转托盘310之间相互滑动，在旋转托盘上表面设置有防滑垫311，当芯片100安放在旋转托盘310时，防滑垫与芯片之间摩擦力增大，进一步提高了锁紧效果。
在本发明一个具体的实施方式中，本发明旋转驱动部400可为电机410，电机410用于带动旋转托盘310转动，继而带动固定在其上的芯片100转动。电机可为直流无刷电机，也可为本领域其它常规电机。
在本发明一个具体的实施方式中，参见附图7-8，本发明锁紧装置300还可包括锁紧连接座330，锁紧连接座330位于旋转托盘310下方，且同轴设置。锁紧连接座330与旋转托盘310可为一体结构，也可为相互独立的部件，当两者为相互独立的部件时，可通过紧固件如螺栓等锁紧(附图所示为相互独立的部件)。
在本发明一个具体的实施方式中，参见附图9-10，锁紧连接座 330通过顶丝331固定在电机410的电机轴420上。当启动电机时，电机带动锁紧连接座330转动继而带动旋转托盘310转动，继而带动芯片转动。
在本发明一个具体的实施方式中，参见附图11，为了避免在安放芯片的过程中，旋转托盘转动，导致锁紧难度增加，本发明锁紧装置300可设置棘轮止转机构340。棘轮止转机构340设置在锁紧连接座330下方，包括带棘轮槽341的棘轮342、V形棘爪343、止转弹簧344和定位销345。其中，V形棘爪343的爪头一346在止转弹簧344的弹力作用下可伸入棘轮槽341中，V形棘爪343的爪头二347与定位销345相连，定位销345可向下压动爪头二347，继而带动爪头一346离开棘轮槽341。当爪头一伸入棘轮槽时，棘轮槽止转，使锁紧连接座停止转动，继而使旋转托盘止转；当爪头一离开棘轮槽时，可启动电机带动旋转托盘转动。在一具体实施方式中，止转弹簧344和定位销345可固定在检查装置的进出仓架210中，当处于出仓状态时，止转弹簧344弹出，在弹力作用下将爪头一346压入棘轮槽341中；当进仓后，定位销345作用，向下压动爪头二347，继而带动爪头一346离开棘轮槽341。
上述实施例只为说明本发明的技术构思及特点，并不用以限制本发明，凡在本发明的精神和原则之内，所作的任何修改、等同替换等，均应包含在本发明的保护范围之内。

Claims (12)

  1. 一种便携式全自动生化分析装置，其特征在于：包括壳体、电源、控制模块和核心模块；
    所述核心模块包括：设置有至少一个检测槽的芯片，能够进出壳体的芯片保持部，设置在芯片保持部上的用于固定和锁紧芯片的锁紧装置，用于使芯片旋转的旋转驱动部，将光照射在芯片检测槽中的光源部，用于接受透过检测槽光的探测部；其中，所述旋转驱动部、光源部和探测部分别与控制模块通讯连接。
  2. 如权利要求1所述的分析装置，其特征在于：所述控制模块设置在壳体内部上方；所述电源与核心模块设置在壳体内部下方。
  3. 如权利要求1所述的分析装置，其特征在于：所述芯片保持部包括进出仓架和传动齿轮；所述进出仓架上设置一通孔，用于安放芯片锁紧装置。
  4. 如权利要求3所述的分析装置，其特征在于：所述传动齿轮位于进出仓架内侧，通过内齿传动方式进行传动。
  5. 如权利要求1所述的分析装置，其特征在于：所述旋转驱动部为电机，所述电机带动电机轴旋转进而带动芯片旋转。
  6. 如权利要求1-5任一项所述的分析装置，其特征在于：所述芯片下表面中央包括一圆形凹槽，所述圆形凹槽沿周向设置有至少一个定位块和至少一个锁紧孔。
  7. 如权利要求6所述的分析装置，其特征在于：所述锁紧装置包括旋转托盘和固定在旋转托盘上方的锁紧圆盘，所述旋转托盘与锁紧 圆盘同轴，且所述旋转托盘直径大于所述锁紧圆盘；其中，所述锁紧圆盘周向设置有至少一个定位凹槽和至少一个锁紧件；所述定位凹槽设置在所述锁紧圆盘外侧，与芯片的定位块配合使用，用于防止芯片与锁紧圆盘之间发生周向移动；所述锁紧件包括带弹簧的锁紧片，所述弹簧位于锁紧圆盘内部的锁紧腔中，所述锁紧片可伸出锁紧腔，与芯片的锁紧孔配合使用，用于防止芯片轴向移动。
  8. 如权利要求7所述的分析装置，其特征在于：所述定位凹槽和锁紧件的数量分别为2-10个，所述定位凹槽和锁紧件沿锁紧圆盘周向均匀设置，且相互间隔。
  9. 如权利要求7所述的分析装置，其特征在于：所述旋转托盘上设置有防滑垫。
  10. 如权利要求7-9任一项所述的分析装置，其特征在于：所述锁紧装置还包括锁紧连接座，所述锁紧连接座位于旋转托盘下方。
  11. 如权利要求10所述的分析装置，其特征在于：所述锁紧连接座通过顶丝固定在所述旋转驱动部上。
  12. 如权利要求10所述的分析装置，其特征在于：所述锁紧装置还包括棘轮止转机构，所述棘轮止转机构包括带棘轮槽的棘轮、V形棘爪、止转弹簧和定位销；其中，所述棘轮设置在锁紧连接座下方，所述止转弹簧和定位销分别设置在芯片保持部上，所述V形棘爪的爪头一在止转弹簧的弹力作用下可伸入棘轮槽中，所述V形棘爪的爪头二与定位销相连，定位销可带动爪头一离开棘轮槽。
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