WO2016157547A1 - Composition topique pour la peau supprimant la transition à une inflammation - Google Patents

Composition topique pour la peau supprimant la transition à une inflammation Download PDF

Info

Publication number
WO2016157547A1
WO2016157547A1 PCT/JP2015/062632 JP2015062632W WO2016157547A1 WO 2016157547 A1 WO2016157547 A1 WO 2016157547A1 JP 2015062632 W JP2015062632 W JP 2015062632W WO 2016157547 A1 WO2016157547 A1 WO 2016157547A1
Authority
WO
WIPO (PCT)
Prior art keywords
extract
acid
genus
derivatives
salt
Prior art date
Application number
PCT/JP2015/062632
Other languages
English (en)
Japanese (ja)
Inventor
藤田　幸子
悟 高山
Original Assignee
一丸ファルコス株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 一丸ファルコス株式会社 filed Critical 一丸ファルコス株式会社
Publication of WO2016157547A1 publication Critical patent/WO2016157547A1/fr

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/535—Perilla (beefsteak plant)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)

Definitions

  • the present invention relates to a composition for suppressing IL-8 gene expression and NO production due to damage-related molecular patterns (DAMPs), and relates to a composition for external application to skin containing inflammation, which contains the composition.
  • DAMPs damage-related molecular patterns
  • DAMPs Damage-related molecular patterns
  • Oxidative-related molecular patterns are released to the outside by the destruction of their own cells and tissues due to external stimuli such as ultraviolet rays, heat, and dryness. It is a general term for molecules that activate cells that have not been received, and keratinocytes activated by DAMPs are known to produce Leukotriene B4, NO, and the like (Non-patent Document 1). DAMPs induce infiltration of mast cells, neutrophils, macrophages, leukocytes and other inflammatory cells in and around the epidermis and play an important role in the development of inflammation.
  • DAMPs examples include sphingosylphosphorylcholine (hereinafter referred to as SPC).
  • SPC sphingosylphosphorylcholine
  • This SPC is a metabolite of sphingomyelin, a lipid that constitutes the cell membrane, and is released to the outside of the cell when the cell breaks, and is reported to have a high concentration in the skin of atopic dermatitis patients (Non-patent Document 2).
  • the barrier function such as the skin of atopic dermatitis patients, dry skin, sensitive skin, etc.
  • the concentration of DAMPs is constantly high in the skin, so that inflammation is maintained and sensory nerves are sustained. It can be assumed that irritation or hate inflammation.
  • an object of the present invention is to suppress the transition to inflammation (redness, thermal sensation, swelling, pain) by controlling the activation of epidermal cells caused by DAMPs.
  • the present inventors screened active ingredients that suppress IL-8 gene expression and NO production of epidermal cells by the DAMPs. I found it.
  • the plant extract shows an effect of improving inflammation, and prevention and improvement of inflammation can be expected by providing an external composition for skin containing these extracts.
  • an IL-8 gene expression inhibitor, a NO production inhibitor, and a composition for external use on skin are provided by DAMPs. Inflammation can be effectively suppressed.
  • FIG. 3 is a diagram showing the IL-8 gene expression inhibitory action of epidermal cells by the perilla extract and the hornon extract of the present invention. It is a figure which shows the NO production inhibitory effect of the epidermis cell by the perilla extract of this invention and a hornon extract.
  • perilla refers to a plant belonging to the family Lamiaceae (Labiatae) and Perilla (Perilla): perilla (Perilla frutescens Britton var. Acuta Kudo).
  • the “Ogon” used in the present invention uses the roots of Labiatae and Scutellaria plants: Scutellaria baicalensis Georgi.
  • each plant body in the plant extract used in the present invention are preferably the parts described above, but in addition, flowers, flower ears, persimmons, fruit skin, fruits, stems, leaves, branches, branches and leaves, trunks, bark, rhizomes.
  • One or more selected from root bark, roots, seeds, aerial parts or whole grasses can be used.
  • the extract is obtained by adding a solvent to the squeezed liquid and / or residue obtained after the squeezing treatment.
  • the extraction solvent for obtaining the plant extract to be used in the present invention may be selected in consideration of the intended purpose and type of the product to be provided, or the processing performed later.
  • water methanol, ethanol , Lower alcohol such as propyl alcohol, isopropyl alcohol, butanol, isobutanol, or water-containing lower alcohol, propylene glycol, 1,3-butylene glycol, 1,2-butylene glycol, 1,4-butylene glycol, 1,5-pentane
  • Polyhydric alcohol such as diol, 1,2-pentanediol, 1,3-pentanediol, 1,4-pentanediol, 1,3,5-pentanetriol, glycerin, polyethylene glycol (molecular weight: 100 to 100,000) or water content
  • Polyhydric alcohol acetone, ethyl acetate, diethyl ether, dimethyl ether, ethyl methyl ether
  • organic solvents such as tellurium
  • the temperature of the solvent, the weight ratio of the solvent to the raw material, or the extraction time can be arbitrarily set for various raw materials and the solvent used.
  • the temperature of the solvent can be arbitrarily set in the range of ⁇ 4 ° C. to 100 ° C., but is preferably around 10 to 40 ° C. from the viewpoint of the stability of the components contained in the raw material.
  • the weight ratio of the solvent to the raw material can be arbitrarily set, for example, within the range of the raw material: solvent of 4: 1 to 1: 100, and the weight ratio of 1: 1 to 1:20 is particularly preferable.
  • the plant extract used in the present invention can be further subjected to a refining operation after solvent extraction.
  • the refining operation includes an acid (hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, organic acid, etc.) or an alkali (water).
  • Decomposition by adding sodium oxide, calcium hydroxide, ammonia, etc., fermentation or metabolic conversion by microorganisms, component adsorption by ion exchange resin, activated carbon, diatomaceous earth, etc., various separation modes (ion exchange, hydrophilic adsorption, hydrophobic adsorption) Fractionation using chromatography with size exclusion, ligand exchange, affinity, etc.), filtration using filter paper, membrane filter, ultrafiltration membrane, etc., pressurization or decompression, heating or cooling, drying, pH Examples include adjustment, deodorization, decolorization, and long-term stationary storage, and it is possible to arbitrarily select and combine them.
  • the shape of the plant extract used for carrying out the present invention may be any shape such as liquid, solid, powder, and paste, and an optimum shape can be arbitrarily selected.
  • the content of the extract is not particularly limited as long as the effect of the present invention can be confirmed, but is generally 0.01 mg / g to 200 mg / g (the denominator indicates the weight of the preparation). ) Range. The range is preferably from 0.1 mg / g to 20 mg / g, most preferably from 1 mg / g to 15 mg / g.
  • the active ingredient can be mixed with a solid or liquid nontoxic pharmaceutical carrier suitable for administration methods such as oral administration, rectal administration and injection, and administered in the form of a conventional pharmaceutical preparation.
  • a solid or liquid nontoxic pharmaceutical carrier suitable for administration methods such as oral administration, rectal administration and injection
  • administration methods such as oral administration, rectal administration and injection
  • preparations include solid preparations such as tablets, granules, powders and capsules, liquid preparations such as solutions, suspensions and emulsions, freeze-dried preparations, and the like. It can be prepared by conventional means.
  • non-toxic pharmaceutical carrier examples include glucose, lactose, sucrose, starch, mannitol, dextrin, fatty acid glyceride, polyethylene glycol, hydroxyethyl starch, ethylene glycol, polyoxyethylene sorbitan fatty acid ester, amino acid, gelatin, Examples include albumin, water, and physiological saline. If necessary, conventional additives such as a stabilizer, a wetting agent, an emulsifier, a binder, and a tonicity agent may be added as appropriate.
  • a cosmetic composition for example, it can be used in various external preparations (including preparations used for animals) in general, specifically, ampoules, capsules, pills, tablets, powders, granules, solids, liquids 1) Pharmaceuticals, 2) Quasi-drugs, 3) Topical or systemic skin cosmetics (eg lotion) , Basic cosmetics such as emulsion, cream, ointment, lotion, oil, pack, facial cleanser and skin cleanser, massage agent, cleansing agent, hair remover, hair remover, shaving treatment, after shave lotion, pre-shave Makeup cosmetics such as lotion, shaving cream, foundation, lipstick, blusher, eye shadow, eyeliner, mascara, perfume, beauty nail, beauty nail enamel, Nail enamel remover, poultice, plaster, tape, sheet, patch, aerosol, etc.), 4) medicinal and / or cosmetic preparations applied to the scalp and hair (eg shampoo, rinse) Hair treatment agents, pre-hair treatment agents, permanent liquids, hair dyes, hair styling agents, hair styling agents, hair
  • the IL-8 gene expression inhibitor, NO production inhibitor, and composition for external use on skin (pharmaceutical composition, cosmetic composition) having an inhibitory action on inflammation transfer of DAMPs include the respective active ingredients.
  • other pigmentation inhibitors exemplified below, tyrosinase activity inhibitors, melanocyte melanin production inhibitors, moisturizers, cell activators / metabolic activators, antioxidants, active oxygen scavengers / Radical production inhibitors, fat metabolism promoters, UV protection agents / UV absorption promoters, astringents, anti-inflammatory agents / interleukin production inhibitors / anti-inflammatory agents, antiseborrheic agents, antibacterial / antiviral agents, blood flow Accelerator / vascular stimulant, antiandrogen, structural proteolytic enzyme (elastase, collagenase, keratin protease, serine protease, integrin degrading enzyme, invol Phospholytic enzyme (elastase, collagenase,
  • hydroquinone ⁇ -D-ribose hydroquinone ⁇ -D-ribose, hydroquinone ⁇ -L-ribose, hydroquinone ⁇ -L-ribose, hydroquinone ⁇ -D-arabinose, hydroquinone ⁇ -D-arabinose , 5-quinone sugar glycosides such as hydroquinone ⁇ -L-arabinose and hydroquinone ⁇ -L-arabinose, hydroquinone ⁇ -D-glucosamine, hydroquinone ⁇ -D-glucosamine, hydroquinone ⁇ -L-glucosamine, hydroquinone ⁇ -L-glucosamine , Hydroquinone ⁇ -D-galactosamine, hydroquinone ⁇ -D-galactosamine, hydroquinone ⁇ -L-galactosamine, hydroquinone ⁇ -L-galactosamine and other amino sugar glycosides, hydroquinone
  • Hydroquinone glycosides such as uronic acid glycosides, hydro Quinone benzyl ether, 4- ⁇ -D-glucopyranosyloxy-1- (4-hydroxyphenoxy) butane, 5- ⁇ -D-glucopyranosyloxy-1- (4-hydroxyphenoxy) pentane, 6- ⁇ -D-glucopyranosyloxy-1- (4-hydroxyphenoxy) hexane, 2- ⁇ -D-glucopyranosyloxy-1- (4-hydroxyphenoxy) propane, 2- ⁇ -D-glucopyra Hydroquinone hydroxyalkyl ether glycosides such as nosyloxy-1- (4-hydroxyphenoxy) butane and 2- ⁇ -D-glucopyranosyloxy-1- (4-hydroxyphenoxy) propan-3-ol) , Kojic acid or salts thereof and derivatives thereof (2-methoxymethyl-hydroxy-4H-pyran-4-one, 2-ethoxymethyl-5-hydroxy-4H-pyran-4-one, 2-benzoyloxymethyl-
  • Cell Activator / Metabolic Activator Vitamin A Group Retinol or its salts and derivatives thereof (retinyl unsaturated fatty acid esters such as retinyl linoleate, retinyl linolenate, retinyl oleate, retinyl arachidonic acid, etc.), Retinal or a salt thereof and derivatives thereof, dehydroretinal or a salt thereof and derivatives thereof, retinoic acid or a salt thereof and derivatives thereof, retinoic acid analog (4-[[[8- (3,5-dimethylphenyl)- 2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (3-methylphenyl) -2-naphthalenyl) carbonyl] amino] benzoic acid, 4-[[[8- (4-methylphenyl)- 2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[[8-
  • Antioxidants Ascorbic acid or its salts and their derivatives (magnesium phosphate-L-ascorbate, ascorbyl palmitate, ascorbyl dipalmitate, ascorbyl hydroxyprophosphate, 5-O- ⁇ -D -Glucopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate sodium salt, L-ascorbic acid phosphate potassium salt, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate calcium salt, L- Ascorbic acid phosphate aluminum salt, L-ascorbic acid sulfate sodium salt, L-ascorbic acid sulfate potassium salt, L-ascorbic acid sulfate magnesium salt, L-ascorbic acid sulfate calcium salt, L-ascorbic acid sulfate Aluminum salt, L- Scorbic acid sodium salt, L-ascorbic acid potassium salt, L-ascorbic acid magnesium salt, L-ascor
  • Reactive oxygen scavenger / radical scavenger Superoxide dismutase, catalase, glutathione peroxidase, bilirubin, quercetin, quercitrin, catechin, catechin derivatives, rutin or its derivatives, gallic acid or its salts and derivatives thereof, curcumin or its Salts and derivatives thereof, transferrin, ceruloplasmin, coenzyme Q, uric acid, bilirubin, metallothionein, stilbenegaloyl glycoside (3,5,4'-trihydroxystilbene 4'-O- ⁇ -D- (6 "galloyl ) Glucopyranoside, 3,5,4'-trihydroxystilbene 4'-O- ⁇ -D- (2 "galloyl) glucopyranoside), chlorogenic acid phospholipid ester, chlorogenic acid sphingosine ester and derivatives thereof, chlorogenic acid glycolipid ester , Chlorogenic acid sugar ester, black Genolic acid
  • Fat metabolism promoter Phthalazine derivatives (4-ethyl-1- ( ⁇ -hydroxyethylamino) phthalazine, 4-N-propyl-1- ( ⁇ -hydroxyethylamino) phthalazine, 4-N-butyl-1- ( ⁇ -hydroxyethylamino) phthalazine, 4-N-butyl-1- ( ⁇ -hydroxypropylamino) phthalazine, etc.), xanthine derivatives (caffeine, theophylline, theobromine, xanthine, aminophylline, choline theophylline, diprofylline, proxyphylline and Oxtriphylline, etc.), Aotsuki-rafuji (wooden candy) extract, thistle extract, aletia thistle extract, pear thistle extract, paddy thistle extract, noel thistle extract, blue thistle extract, cacao extract, elcampuri extract, ots
  • UV protective agent / UV absorption accelerator Benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid Sodium, dihydroxydimethoxybenzophenone, dihydroxydimethoxybenzophenone-sodium sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), 1,2-dihydroxy-4- (2-hydroxyethyl) benzene derivatives (1- (2- ( 4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (6- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) ) Glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (2-
  • Astringents Succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, potassium aluminum sulfate, resorcin, ferric chloride, tannins (tannic acid, hamellitannin, Acer Gallotannins such as tannin, tetragalloyl glucose, pentagalloyl glucose, hexagalloyl glucose, heptagalloyl glucose, octagalloyl glucose, nonagaroyl glucose, decagalloyl glucose, undecagalloyl glucose, dodecagalloyl glucose , Telimaglandin I, Telimaglandin II, Casuaricin, Peducraggin, Geraniin, Isoturkevin, Granatin A, Granatin B, Kevulinic acid, Keblagic acid, Casuarinin, Nufarin, Procyanidin B-2, Thias
  • Antibacterial agent Acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or hydrolyzate thereof, alkyldiaminoethylglycine chloride solution, triclosan, sodium hypochlorite, chloramine T, salami powder, iodine Compound, iodoform, 1-alkylcarbapenem compound, N-substituted azepane derivative or salt thereof, sorbic acid or salt thereof, propionic acid or salt thereof, salicylic acid or salt thereof, dehydroacetic acid, parahydroxybenzoic acid ester, 2-keto -3-deoxyoctanoic acid fatty acid ester, inositol deoxy derivatives (such as quercitol), inositol unsaturated derivatives (such as chonditol), inositol dimethyl ether, methyl inositol,
  • Antiandrogens Follicular hormones (estrone, estradiol, ethinyl estradiol, etc.), isoflavones, oxendron, 4 ', 5,7-trihydroxy-8-prenylflavanone, 4', 5,7-trihydroxy-8-prenyl Flavone, 3,3 ′, 4 ′, 5,7-pentahydroxy-8-prenylflavone, nicorandil, cyclosporic acid and the like.
  • Activity inhibitor of structural proteolytic enzymes elastase, collagenase, keratin protease, serine protease, integrin degrading enzyme, involucrin degrading enzyme, filaggrin degrading enzyme, laminin degrading enzyme, fibronectin degrading enzyme, proteoglycan degrading enzyme
  • Structural proteolytic enzyme expression inhibitor Adenine derivatives (butanetriol-9-adenine and its phosphate adduct, propanediol-9-adenine and its phosphate adduct, pentanetriol-9-adenine and its phosphate adduct, etc.
  • Carbostyril derivatives or salts thereof dicarboxylic acids (glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid, 1,9-nonamethylenedicarboxylic acid, 1,10-decamethylenedicarboxylic acid), rosuma Acid, ursolic acid, oleanolic acid, hydroxamic acid derivative, esculetin derivative, anthocyanidins, nordihydroguaiaretech acid, 20-carboxy-16-hydroxy-21-nor-5 ⁇ -7,9 (11) -lanostadien- 3,24-dione, ubiquinone, plataquinone, yuglone, shikonin, quinizarin, alizarin, abietin, levopimar, betulin, ⁇ -amylin, catechin compounds (catechin, epigallocaequine, epigallocatechin gallate, epicatechin, epicatechin gall gall gall
  • Structural protein synthesis promoter Ethanolamine derivative, pentoxyphyllin, serine derivative, geraniol, crocetin, methyl 4- (2-ethylhexyloxy) -2-hydroxybenzoate, 2-hydroxy-4- (3,5, 5-Trimethylhexyloxy) methyl benzoate, methyl 4-cyclohexylmethoxy-2-hydroxybenzoate, methyl 4- (2-cyclohexylethoxy) -2-hydroxybenzoate, 4- (3,7-dimethyl-6-oct Methyl tenenyloxy) -2-hydroxybenzoate, ethyl 3- (2-ethylhexyloxy) -5-hydroxybenzoate, methyl 5- (2-ethylhexyloxy) -2-hydroxybenzoate, 2-hydroxy-5- ( 3,5,5-Trimethylhexyloxy) methyl benzoate, methyl 5- (2-cyclohexylethoxy) -2-hydroxybenzoate, methyl 4-(
  • Mucopolysaccharide (hyaluronic acid, chondroitin sulfate, etc.) degrading enzyme inhibitors
  • Anacardic acid or its derivatives (6-pentadecatrienylsalicylic acid methyl ether, 6-pentadecatrienylsalicylic acid ethyl ether, 6-pentadecatrienyl) Salicylic acid propyl ether, 6-pentadecatrienyl salicylic acid butyl ether, 6-pentadecatrienyl salicyl alcohol methyl ether, 6-pentadecatrienyl salicyl alcohol ethyl ether, 6-pentadecatrienyl salicyl alcohol propyl ether, 6-pentadeca Trienyl salicyl alcohol butyl ether, 6-pentadecatrienyl salicylaldehyde methyl ether, 6-pentadecatrienyl salicylaldehyde ethyl ether, 6-pent
  • intercellular adipogenesis promoter / intercellular lipid state improving agent phospholipids phosphatidylethanol, phosphatidylcholine, phosphatidyltriethanolamine, phosphatidylserine, phosphatidic acid, phosphatidylglycerol, phosphatidylinositol, diacylphosphatidylcholine, diacylphosphatidylethanolamine, Diacylphosphatidylinositol, diacylphosphatidylserine, 1-cysteinylphosphatidic acid, 2-cysteinylphosphatidic acid, 1-glutathionylphosphatidic acid, 2-glutathionylphosphatidic acid, 1-azelaoylphosphatidic acid, 2-azela Oil phosphatidic acid, 1-hydroxyacyl phosphatidic acid, 2-hydroxyacyl phosphatidic acid, ceramide, glucosylceramide, Lactosylceramide, cerebroside, phosphatidyl
  • Testosterone 5 ⁇ reductase activity inhibitor ⁇ -amino- ⁇ -hydroxybutyric acid esters ( ⁇ -amino- ⁇ -hydroxybutyric acid methyl ester, ⁇ -amino- ⁇ -hydroxybutyric acid ethyl ester, ⁇ -amino- ⁇ -hydroxybutyric acid) Propyl ester, ⁇ -amino- ⁇ -hydroxybutyric acid butyl ester, ⁇ -amino- ⁇ -hydroxybutyric acid ethylhexyl ester, ⁇ -amino- ⁇ -hydroxybutyric acid hexadecyl ester, ⁇ -amino- ⁇ -hydroxybutyric acid lauryl ester, ⁇ - Amino- ⁇ -hydroxybutyric acid stearyl ester, ⁇ -amino- ⁇ -hydroxybutyric acid oleyl ester, ⁇ -amino- ⁇ -hydroxybutyric acid benzyl ester, ⁇ -amino- ⁇ -
  • glyceride sulfate monopentadecyl Glyceryl ether sulfate, 1-O-hexadecyl-2-O-methylglycerol, 1-O-octadecy -2-O-methylglycerol, 1-O-oleyl-2-O-methylglycerol, acetylcarnitine or its salt, geranylgeranylacetone, hydroxamic acid derivative or its salt, gingerone glycoside, benzeneoxyacetic acid derivative ([5- [2- [1-phenyl-1- (3-pyridyl) methylideneaminooxy] ethyl] -7,8-dihydronaphthalen-1-yloxy] acetic acid, etc.), isorhamnetin-3-robinobioside, xanthone derivatives , Proanthocyanidins (grape seed extract proanthocyanidins, apple-derived proanthocyanidins, pine-derived proant
  • Odor-eliminating agent Inond extract, Elemi extract, Danmar extract, vanilla bins extract, pine extract and the like.
  • Composita spp. Kojimari extract Calyx genus Camono mono extract, Fennel genus Falcon extract, Cultiva turmeric extract, Cicaria chrome extract, Chrysanthemum genus Chrysanthemum extract, Nerecomb genus Nerecomb extract, Uchimo genus Oukimo extract, Burukimo genus Burukimo extract, Brown algae extract such as mosquito genus mosquito extract, Amanori genus Uprinori extract, Amanori genus Onianori extract, Amanori genus Tasa extract, Amanori firitasa extract, Amanori Benitasa extract, Rhodocorton milnobeni extract, Konahada spp. L.
  • pine extract Nisefusanori genus Fusanori extract, Sodegara genus Sodegarami extract, Hirohataidai genus Hirohatamitaki extract, Amanita Nambugusa extract
  • Tengusa spp. Mon extract Nisekarekigusa Nisekarekigusa extract, Okitsubara Oobakutara extract, Sangomomoda Ragaradoki extract, Shiogusagoromo Shiogusagoromo extract, Iwanokawa Etsukiiwanokawa extract, Kinokawa Coral extract, Centipede spruce extract, Centipede spruce extract, Centacum spruce extract, Centacum spp.
  • Red Algae Extracts Shajikumo, such as the genus Isobasho Extract, Ideukogome Ideukogome Extract, Ochimomoku Okichimozuku Extract, Chisujinori Chisujinori Extract Kiss, white ball mode extract, Hoshitsurimo genus Hoshitsurimoekisu, Riku Roh Tam Taunus extract, Furasukomo genus Princess flask model extract, bantams flask model extract, axle algae extract such as Toriperaekisu, yellow algae extract such as Chromophyton rosanoffii genus Chromophyton rosanoffii extract.
  • any site, cell, tissue, organ, metabolite, etc. derived from a transgenic body or a cell fusion body can also be used. Furthermore, it is obtained by culturing cells of any site, cell, tissue, organ, etc., for example, cultured cells derived from each tissue (cultures derived from animals such as fibroblasts, Langerhans cells, macrophages, epidermal cells, hepatocytes, etc.) Cell etc.), undifferentiated cell group, cell group in the middle of differentiation, and their metabolites can also be used.
  • Seawater such as deep sea water, for example, sea salt, dried sea water, dead sea or Atlantic or Pacific sea mineral salts (sodium chloride, magnesium chloride, (Potassium chloride, etc.), sea mud or mud (Fango), for example, Italian mud, German fungo, Eifelfango, Kon fungo, etc.
  • Sea mud or mud containing components: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide) , Manganese oxide, sodium oxide, potassium oxide, magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), saintoku stone, etc. Marine components etc.
  • Extracts derived from plant-based raw materials, animal-based raw materials, microbial-based raw materials, and other natural product raw materials used as active ingredients or additives are processed in a conventional manner according to the product type and form to be added (for example, pulverized) , Milling, washing, extraction, degradation, fermentation or metabolic conversion by microorganisms, fractionation, purification, pressing, filtration, drying, powdering, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. It is only necessary to select and use any of various materials.
  • the solvent used for extraction may be selected in consideration of the intended purpose and type of the product to be provided or the processing to be performed later. Usually, water, methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, isopropanol are used.
  • Lower alcohol such as butanol or hydrous lower alcohol, propylene glycol, 1,3-butylene glycol, 1,2-butylene glycol, 1,4-butylene glycol, 1,5-pentanediol, 1,2-pentanediol, 1, Polyhydric alcohol or hydrous polyhydric alcohol such as 3-pentanediol, 1,4-pentanediol, 1,3,5-pentanetriol, glycerin, polyethylene glycol (molecular weight 100 to 100,000), acetone, ethyl acetate, diethyl ether , Dimethyl ether, ethyl methyl ether, dioxane, acetonitrile
  • organic solvents such as xylene, benzene, chloroform, carbon tetrachloride, phenol, toluene, etc., acids (hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, formic acid, acetic acid
  • the temperature of the solvent, the weight ratio of the solvent to the raw material, or the extraction time can be arbitrarily set for various raw materials and the solvent used.
  • the temperature of the solvent can be arbitrarily set in the range of ⁇ 4 ° C. to 100 ° C., but is preferably around 10 to 40 ° C. from the viewpoint of the stability of the components contained in the raw material.
  • the weight ratio of the solvent to the raw material can be arbitrarily set within the range of, for example, the raw material: solvent of 4: 1 to 1: 200, and the weight ratio of 1: 1 to 1:10 is particularly preferable.
  • Seaweed (Green algae: Chlorella vulgaris, Chlorella pyrenoidosa, Chlorella ellipsoidia, Aonori (Usubaonori, Sugiaonori, Hiraaoori, Bouaoonori, Hosoeda Aonori), Anaaoosa (seaweed)] [Brown algae: Kombu (Macombu, Risilibu, Hosome Kombu, Mitsuishi Kombu), Wakame, Hirome, Aowakame, Giant Kelp (Macrocystis pirifera, Macrocystis integrifolia, Neocitus Luetkeana), Hijiki, Hibamata, Umiuchiwa, Usuba Umiuchiwa, Kirebanoumiuchiwa, Akaba Umiuchiwa, Konaumi Uchiwa, Okinawa Uchiwa, Usuki Uchiwa, Etsuuki Uchiwa],
  • algae such as green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Anemone: Quanomomo, Volbox: Ougenmawari, Volbox, Palmera, Yotsumeo, Aomido: Chrysanthemum, Aoumidro, Tirguimidro, Hibidoro: Hibidoro, Aosa: Anaaaosa, Amiaosa, Nagaaosa, Kawanori: Kawanori, Friccella, Shiogusa Magama genus: Magamata, Iwagata: Fusaikawa, Surichogi, Heraiwata, Kurokita, Hanemo, Genus: Mill, Chromel, Sakibuchimil, Nagamil, Hihi Mil, Casanori genus: Casanori, Jusmo genus: Fut
  • Cyanobacteria Suizenjinori: Suizinori, Aoko, Nenomo: Kawatake, Ishijelly, Hassai, Yuremo, Rasenmo (Spirulina): Spirulina, Trichodesmium (Aiacacio), etc.).
  • Red algae Genus Sea urchins, Tsukumonori, Anemone crickets, Astragalus, Amaranthus, Amaranthus, Agaricata Genus: Tamaitadaki, Kagikenori Genus: Kaginori, Kagikenori, Proboscis spp .: Himetengususa, Hytengususa, Oobusa, Nambu Sasa, Kohira, Yohira, Kinuxa, Hibirodo: Hibirodo, Himebirodo, Isomumedodomo: Isomumedodomo: Physarum genus: Rhizogae, Ryumonsou: Ryumonara, Rana genus , Naminohana genus: Hosovanaminohana, Naminohana, Sangomodoki: Ragaramomodoki, Shiogusagoromo: Shiogusagoromo, Iwanokawa genus: Etsukiiwan
  • Isomocca genus Isomocca, Yukari genus: Yukari, Hosoyukari, Ibaranori genus: Ibaranori, Saidaibara, Tachiibara, Kagibaranori, Kojinoo: Kizino-o, Isodantsu: Isodantsu, Atsubanori: Atsubanori, Ogonori, Ogonori, Ogori Mizo-okonori, birch, beniogonori, fukureshinori, purple birch, shinkaibanori, spruce birch, kataogonori, ryukyuo Nori, Prunus serrata, Hitsuginu, Yumigataonogori, Kuboreogonori, Mosagoonori, Kinubanori, Proboscis genus: Beetle genus, Prunus genus: Nymphaea genus Itagususa, Saimi, Hari, Lotus Jigusa
  • Axle algae (Shajikumo, Shiratamamo, Hoshitsurimo: Hoshitsurimo, Rikunotamusu, Flaskmo: Himebumo, Chaboflasmo, Tripera, etc.), yellow algae (Hikarimo: Hikarimo, etc.), etc.
  • any site, cell, tissue, organ, metabolite, etc. derived from a genetically modified body or a cell fusion body can also be used.
  • an undifferentiated cell group, a cell group in the middle of differentiation, or the like obtained by culturing an arbitrary site, cell, tissue, organ or the like can also be used.
  • Decomposition in processing mainly includes decomposition with acid, decomposition with alkali, decomposition with enzyme, decomposition with high temperature and pressure, and the like.
  • the decomposition with an acid for example, it is preferable to use an inorganic acid or an organic acid such as hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, acetic acid, formic acid, oxalic acid, hydrogen bromide, perchloric acid, and periodic acid.
  • alkali for example, sodium hydroxide, potassium hydroxide, calcium hydroxide, ammonium hydroxide, barium hydroxide, sodium carbonate, ammonium carbonate, calcium carbonate, magnesium hydroxide, sodium silicate, etc.
  • the concentration, reaction time, reaction temperature, and the like can be arbitrarily set for the target raw material.
  • an enzyme having a function of degrading proteins, polysaccharides, lipids or complexes thereof having an important function particularly with respect to cell structure, tissue structure, etc. for example, aminopeptidase, dipeptidase, dipeptide Peptidyl peptidase, tripeptidyl peptidase, carboxypeptidase, serine protease, trypsin, chymotrypsin, cysteine protease, thiol protease, papain, aspartate endopeptidase, metalloendopeptidase, promeline, thermolysin, pronase, pepsin, rennin, Proteolytic enzymes (proteases) such as pancreatin, chymopap
  • Fermentation or metabolic conversion by microorganisms can be carried out by inoculating and growing at least one or more microorganisms on a raw material used as a substrate. Inoculation of microorganisms to the substrate can be done by adding microorganisms directly into the substrate, or by adsorbing them on a carrier such as alginic acid, polyvinyl, gelatin, etc., for example, in the form of fine beads composed of microorganisms and carrier. Further, it can be used by being fixed to the tube wall of the bioreactor.
  • Fermentation or metabolic conversion by microorganisms is not particularly defined as a microorganism to be used, but can generally be defined as microorganisms other than pathogenic microorganisms that exhibit significant toxicity to living bodies.
  • microorganisms to be used include, but are not limited to, yeasts classified into the genus Aciculoconidium, Actonia, Aessosporon, Ambrosiozyma, Amphierna, Anthomyces, Apiotrichum, Arthroascus, Arxula, Ascotrichosporon, Ashbia, Ashbya Genus, Asporomyces, Atelosaccharomyces, Azymocandida, Azymohansenula, Azymomyces, Azymoprocandida, Babjevia, Ballistosporomyces, Basidiotrichosporon, Bensingtonia, Blastobotrysbota, Blastodlastrzo Brettanomyces (Bretta
  • Microorganisms classified as bacteria include Acetobacter genus (Acetobacter aceti, etc.), Achromobacter genus, Acidianus genus, Acidobacterium genus, Acidithiobacillus genus, Acrocarpospora genus, Actinoalloteichus genus, Actinocorallia genus, Actinokineospora genus, Actinomadspura genus, Actinomadspura Actinosynnema genus, Aerococcus genus, Aeromicrobium genus, Agrobacterium genus, Agromyces genus, Ahrensia genus, Alcaligenes genus, Alicyclobacillus genus, Alloiococcus spp.
  • Aureobacterium genus Aureobacterium genus, Azotobacter genus, Bacillus genus (Bacillus brevis, Bacillus subtilis etc.), Bacteroides genus, Beneckea genus, Bifidobacterium genus (Bifidobacterium bifidum, Bifidobacterium longum, Bifidobacterium breve, Bifidobacterium infantis etc.), Brachybacterium genus, Brevicillus, Brevundimonas, Burkholderia, Carnobacterium, Catellat genus ospora, Cellulomonas, Chainia, Chromobacterium, Chryseobacterium, Citrobacter, Clavibacter, Corynebacterium, Couchioplanes, Cryptosporangium, Curtobacterium, Dactylosporangium, Deinococcus, Delftia, Dermatia, Dermatia ,
  • Lactobacillus parakefiri Lactobacillus pentosus, Lactobacillus plantarum, Lactobacillus reuteri, Lactobacillus rhamnosus, Lactobacillus sakei, Lactobacillus confusus, Lactobacillus viridescens, Lactobacillus johnsonii, Lactobacillus viscosus, Lactobacillus bunchneri , Lactobacillus fermentatae, Lactobacillus acidophil-aerogenes, Lactobacillus leichmannii, Lactobacillus gasseri, Lactobacillus bifidus, Lactobaci llus jugurt, Lactobacillus caucasicus, Lactobacillus arabinosus, Lactobacillus kunkeei, Lactobacillus nagelii, Lactobacillus fornicalis, Lactobacillus pentoaceticus, Lactobacillus x
  • Genus Nocardioides, Nonmuraea, Nonomuria, Oceanospirillum, Ochrobactrum, Oerskovia, Oligella, Paenibacillus, Pediococcus ui, etc.), Pedobacter, Peptococcus, Peptostreptococcus, Pilimelia, Pimelobacter, Planobispora, Planococcus, Planomonospora, Prevotella, Propionibacterium, Proteus, Protomonas, Pseudomonas, Genus, Rathayibacter, Rhizobium, Rhizomonas, Rhodobacter, Rhodococcus, Rhodopseudomonas, Rhodospirillum, Rothia, Rubrobacter, Ruegeria, Saccharomonospora, Siracrothinas, Sporolactobacillus spp., Stenotrophomonas spp., Streptoalloteich
  • Streptococcus durans Streptococcus faecalis, Streptococcus faecium, Streptococcus bovis, Streptococcus equinus, Streptococcus mutans, Streptococcus salivarius, Streptococcus thermophilus, Streptococcus agalactiae, Streptococcus mitis, Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus lactis , Streptococcus dysgalactiae, Streptococcus sanguis, Streptococcus acidominimus, Streptococcus avium, Streptococcus uberis, Streptococcus cremoris, Streptococcus diacetilactis, etc.
  • Microorganisms classified as non-yeast ascomycetes, basidiomycetes or incomplete fungi include Allomyces, Amoebidium, Amorphotheca, Arthroderma, Ascoidea, Ascobolus, Ascodesmis, Aspergillus, Aureobasidium, Botryosphaeria , Botryotinia, Brachybasidium, Byssochlamys, Capnodium, Ceratocystis, Ceratomyces, Chaetomium, Chrysella, Chrysocelia, Chytridium, Claviceps, Cochliobolus, Coemansia, Genus Genus, Cyttaria, Dasyspora, Derchslera, Derchmyces, Dichomyces, Dothidea, Endogone, Entomophthora, Emericella, Eupenicillium, Eurotium, Exobasidium, Gibberella, Glomus, Graphiola, Graphnoola
  • Sordaria genus Sporidiobolus genus, Stibella genus, Stigmatomyces genus, Sydowiella genus, Talaromayces genus, Taphrina genus, Thraustochytrium genus, Tolyposporium genus, Trichoglossum genus, Trichoma genus, Ustilago genus, Verticillium genus, Xylaria genus and the like.
  • microorganisms In fermentation or metabolic conversion by microorganisms, in addition to various raw materials such as plant-based materials, animal-based materials, and other natural product-based materials, the growth and metabolism of microorganisms are regulated or activated, and special biosynthesis or degradation pathways are induced. In order to achieve this, various compounds can be added to the raw material.
  • a sugar or ethane such as glucose, fructose, galactose, sucrose, maltose, mannose, lactose, glycerol, starch, etc.
  • Hydrocarbons such as methane, propane, butane, formic acid, acetic acid, propionic acid, lauric acid, palmitic acid, fatty acids such as oleic acid, linoleic acid, linolenic acid, etc., nitrogen sources such as ammonium sulfate, ammonium hydrochloride, ammonium phosphate, etc. Ammonium salt, urea, uric acid, amino acids, etc. Vitamins and compounds containing potassium, calcium, magnesium, sodium, sulfur, phosphorus, chlorine, etc.
  • the optimum temperature, oxygen supply amount, pH, pressure, etc. that affect the growth and metabolic activity of various microorganisms can be arbitrarily set according to the characteristics inherent to various microorganisms. Can be arbitrarily set in the range of 10 to 50 ° C., and the pH can be arbitrarily set in the range of 1 to 14.
  • fractionation or purification generally known techniques can be used as appropriate.
  • solvent extraction for example, liquid chromatography (ion exchange chromatography, ion exclusion chromatography, affinity chromatography, gel filtration chromatography, size exclusion chromatography, etc.).
  • Red No. 3 Red No. 102, Red No. 104 (1), Red 105 (1), Red 106, Red 201, Red 227, Red 230 (1), Red 230 (2), Red 231, Red 232, Red 401, Color 502, Red 503, Red 504, Red 506, Yellow 4, Yellow 5, Yellow 202 (1), Yellow 202 (2), Yellow 203, Yellow 402, Yellow 403 No. (1), yellow 406, yellow 407, orange 205, orange 207, orange 402, green 3, green 204, green 205, green 401, green 402, brown 201, Purple No. 401, Blue No. 1, Blue No. 2, Blue No. 202, Blue No. 203, Blue No. 205, Black No.
  • Red Cabbage Dye Red Rice Dye, Akane Dye, Anato Dye, Ikumi Dye, Turmeric Dye, Enju Dye , Krill pigment, Amber pigment, Caramel, Gold, Silver, Gardenia pigment, Corn pigment, Onion pigment, Tamarind pigment, Spirulina pigment, Buckwheat whole plant pigment, Cherry pigment, Nori pigment, Hibiscus pigment, Grape juice Dyes, marigold dyes, purple potato dyes, purple yam dyes, lac dyes, rutin and other pigments and colorants, avocado oil, almond oil, fennel oil, sesame oil, olive oil, orange oil, orange raffer oil, sesame oil, cocoa butter , Chamomile oil, carrot oil, cucumber oil, beef tallow fatty acid, cucumber nut oil, safflower oil, shea fat, liquid shea fat, soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil
  • Test conditions The following tests 1 to 3 were performed on the plant extracts obtained in Production Examples 1 to 6.
  • the cells were commercially available normal human epidermal keratinocytes (Kurabo), the cell culture medium was EpiLife KG2 (Kurabo) medium as the preculture medium, and hEGF from the preculture medium as the test medium. The thing except hydrocortisone and BPE was used. Both pre-culture and main test culture were performed according to the manufacturer's instructions. In addition, the results of Tests 1 and 2 all indicated relative values with the control as 100.
  • IL-8 is produced from various cells such as leukocytes and skin epidermal cells as well as fibroblasts and endothelial cells by stimulation of inflammatory cytokines such as DAMPs, IL-1 and TNF ⁇ . It acts mainly as a neutrophil migration factor and serves to collect inflammatory cells at the site of inflammation. Therefore, suppression of IL-8 can be expected to suppress the onset of inflammation.
  • inflammatory cytokines such as DAMPs, IL-1 and TNF ⁇ .
  • Test method Normal human epidermal keratinocytes were seeded on culture plates and pre-cultured until 100% confluent. Thereafter, the medium was replaced with the test medium and cultured for 24 hours. The next day, the medium was replaced with a fresh medium for this test, and each plant extract obtained in Production Examples 1 to 6 was added to the culture solution. After culturing the cells for 24 hours, 10 ⁇ M SPC is added to normal human epidermal keratinocytes. After culturing for 4.5 hours, total RNA is prepared, and the relative expression level of IL-8 mRNA is measured by Real-time PCR method. did. The final concentration of perilla extract is 0.1% and 0.01%, and the final concentration of ougon extract is 0.1%.
  • Test results As shown in FIG. 1, the results of the plant extracts obtained in Production Examples 1 to 6 under the condition that SPC is allowed to act on normal human epidermal keratinocytes to enhance the expression of IL-8 gene. In addition, an IL-8 gene expression inhibitory action was observed.
  • any cream containing a plant extract has an improvement effect on itching of the skin and atopic dermatitis.

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

La présente invention aborde le problème consistant à supprimer la transition à une inflammation (rougeur, chaleur, gonflement, douleur) en régulant l'activation de cellules épithéliales attribuables aux DAMP. Les inventeurs ont recherché par criblage des principes actifs permettant de supprimer la production de NO et l'expression génique d'IL-8 de cellules épithéliales activées par la stimulation de DAMP, résultant en la découverte d'effets suppresseurs dans un extrait de perilla et un extrait de scutellaria. La présente invention concerne une composition topique pour la peau supprimant la transition à une inflammation ou analogue comprenant ces extraits utilisés comme principes actifs.　
PCT/JP2015/062632 2015-03-31 2015-04-27 Composition topique pour la peau supprimant la transition à une inflammation WO2016157547A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2015072717A JP2016190822A (ja) 2015-03-31 2015-03-31 炎症移行抑制皮膚外用組成物
JP2015-072717 2015-03-31

Publications (1)

Publication Number Publication Date
WO2016157547A1 true WO2016157547A1 (fr) 2016-10-06

Family

ID=57004069

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2015/062632 WO2016157547A1 (fr) 2015-03-31 2015-04-27 Composition topique pour la peau supprimant la transition à une inflammation

Country Status (2)

Country Link
JP (1) JP2016190822A (fr)
WO (1) WO2016157547A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2723483C1 (ru) * 2019-06-04 2020-06-11 Светлана Николаевна Бутова Косметический крем для рук
CN112137924A (zh) * 2020-08-25 2020-12-29 荣鼎(广东)生物科技有限公司 一种具有美白功能的润肤霜
WO2022255654A1 (fr) * 2021-06-04 2022-12-08 주식회사 벡스퍼트 Composition pharmaceutique pour la prévention ou le traitement de la gingivite ou de la parodontite comprenant un extrait d'aucuba japonica

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102417303B1 (ko) * 2017-11-24 2022-07-06 (주)아모레퍼시픽 아토피 피부염 예방 또는 개선용 조성물
KR102118540B1 (ko) * 2017-12-28 2020-06-03 우용규 항염증 및 항균효과를 가지는 a.c.c. 추출물 및 이를 유효성분으로 포함하는 조성물
KR102362617B1 (ko) * 2018-05-16 2022-02-11 오오타 유시 가부시키가이샤 피부의 광노화 예방제, 및, 이것을 함유하는 기능성 화장품
JP2021054774A (ja) * 2019-10-02 2021-04-08 ポーラ化成工業株式会社 好中球遊走促進因子の遺伝子発現抑制剤
KR102361014B1 (ko) * 2021-10-18 2022-02-14 큐티스바이오 주식회사 더마코쿠스 니시노미야엔시스의 피부 상태 개선 용도
WO2024048260A1 (fr) * 2022-08-29 2024-03-07 株式会社菊星 Composition de coiffage et procédé de traitement de coiffure

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000136122A (ja) * 1998-10-28 2000-05-16 Kose Corp 皮膚外用剤
JP2002053487A (ja) * 2000-08-10 2002-02-19 Club Cosmetics Co Ltd マクロファージ活性剤及び皮膚外用剤並びに健康食品

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000136122A (ja) * 1998-10-28 2000-05-16 Kose Corp 皮膚外用剤
JP2002053487A (ja) * 2000-08-10 2002-02-19 Club Cosmetics Co Ltd マクロファージ活性剤及び皮膚外用剤並びに健康食品

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ASIAN PAC. J. CANCER PREV., vol. 15, 2014, pages 4129 - 4133 *
BIOL. PHARM. BULL., vol. 25, no. 3, 2002, pages 367 - 371 *
J. COSMET. LASER THER., vol. 16, 2014, pages 271 - 278 *
JAPANESE JOURNAL OF PEDIATRICS, vol. 66, no. 5, 2013, pages 157 - 162 *
MOL. MED. REP., vol. 10, 2014, pages 1077 - 1083 *
PREV. NUTR. FOOD SCI., vol. 17, 2012, pages 109 - 115 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2723483C1 (ru) * 2019-06-04 2020-06-11 Светлана Николаевна Бутова Косметический крем для рук
CN112137924A (zh) * 2020-08-25 2020-12-29 荣鼎(广东)生物科技有限公司 一种具有美白功能的润肤霜
WO2022255654A1 (fr) * 2021-06-04 2022-12-08 주식회사 벡스퍼트 Composition pharmaceutique pour la prévention ou le traitement de la gingivite ou de la parodontite comprenant un extrait d'aucuba japonica

Also Published As

Publication number Publication date
JP2016190822A (ja) 2016-11-10

Similar Documents

Publication Publication Date Title
WO2016157547A1 (fr) Composition topique pour la peau supprimant la transition à une inflammation
JP5730837B2 (ja) メラニン生成抑制剤、保湿剤、美白化粧料、美容飲食品
JP2006290749A (ja) メラニン生成抑制剤
JP2006117612A (ja) 活性酸素消去剤
JP2006124355A (ja) ファゴサイトーシス抑制剤
JP4800049B2 (ja) ｍＴＯＲを活性化する製剤及びｍＴＯＲを活性化する方法
JP2015063479A (ja) 植物抽出物によるカスパーゼ−１４発現誘導剤
JP2004210699A (ja) 化粧料組成物
JP2006347926A (ja) ファゴサイトーシス抑制剤
JP2010241777A (ja) アクアポリン産生増強製剤及びその方法
JP5878714B2 (ja) リンパ管腔形成促進剤
JP2006104098A (ja) ヒアルロニダーゼ活性阻害剤
JP4562466B2 (ja) ニーム抽出物の製造方法及びこれを含有する低刺激性化粧料組成物
JP2006117613A (ja) メラニン生成抑制剤
JP4814509B2 (ja) ジアリールヘプタノイド誘導体を有効成分とするメラニン生成抑制剤と皮膚外用剤、飲食品への応用
JP5756326B2 (ja) キネシン抑制剤
JP2015101571A (ja) 絹の亜臨界水処理物の製造法及び化粧料組成物
JP2010083838A (ja) アディポネクチン産生促進剤
JP2016190823A (ja) 神経成長因子抑制剤
JP5210786B2 (ja) 発毛を抑制又は毛の成長を抑制するための薬剤
JP6025684B2 (ja) フェニルエチルアミン誘導体又はシネフリンによるカスパーゼ−１４発現誘導剤
JP2013087057A (ja) アクアポリン産生増強製剤
JP2006193477A (ja) ウレアーゼ阻害剤
JP2013087058A (ja) アクアポリン産生増強製剤
JP5236704B2 (ja) チロシナーゼ活性阻害剤

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 15887689

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 15887689

Country of ref document: EP

Kind code of ref document: A1