WO2016140005A1 - Corps poreux et dispositif de filtre - Google Patents

Corps poreux et dispositif de filtre Download PDF

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Publication number
WO2016140005A1
WO2016140005A1 PCT/JP2016/053089 JP2016053089W WO2016140005A1 WO 2016140005 A1 WO2016140005 A1 WO 2016140005A1 JP 2016053089 W JP2016053089 W JP 2016053089W WO 2016140005 A1 WO2016140005 A1 WO 2016140005A1
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Prior art keywords
porous body
region
plan
support
thickness direction
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PCT/JP2016/053089
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English (en)
Japanese (ja)
Inventor
誠治 神波
近藤　孝志
萬壽　優
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株式会社村田製作所
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Publication of WO2016140005A1 publication Critical patent/WO2016140005A1/fr

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D29/00—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor
    • B01D29/01—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor with flat filtering elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D46/00—Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
    • B01D46/10—Particle separators, e.g. dust precipitators, using filter plates, sheets or pads having plane surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/06—Flat membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/10—Supported membranes; Membrane supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/10—Supported membranes; Membrane supports
    • B01D69/108—Inorganic support material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/12—Composite membranes; Ultra-thin membranes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/24—Methods of sampling, or inoculating or spreading a sample; Methods of physically isolating an intact microorganisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/10—Devices for withdrawing samples in the liquid or fluent state

Definitions

  • the present invention relates to a porous body and a filter device.
  • Patent Document 1 International Publication No. 2014/050328. No.
  • a method of irradiating an electromagnetic wave to a porous body in which a target object is collected is known in order to measure the characteristics of the target object (see, for example, Patent Document 2 (Japanese Patent Laid-Open No. 2007-10366)).
  • Patent Document 2 Japanese Patent Laid-Open No. 2007-10366
  • the measurement sensitivity can be increased by reducing the thickness of the porous body.
  • an object of the present invention is to provide a porous body and a filter device that are less likely to be deformed or damaged while realizing high measurement sensitivity and reduced pressure loss.
  • a porous body including a through hole arrangement portion having a plurality of through holes In a plan view as viewed from the thickness direction of the porous body, a partial region of the through-hole arrangement portion is defined as a first region, includes an outer peripheral edge of the through-hole arrangement portion, and is more on the outer peripheral side than the first region.
  • a partial region of the through hole arrangement portion located between the first region and the second region in the plan view as viewed from the thickness direction of the porous body is defined as a third region.
  • the volume occupancy rate of the constituent member of the porous body in the third region is higher than the volume occupancy rate of the constituent member of the porous body in the first region, and the constituent member of the porous body in the second region.
  • An average interval between the plurality of through holes in the third region is longer than an average interval between the plurality of through holes in the first region, and is longer than an average interval between the plurality of through holes in the second region.
  • the thickness of the porous body in the third region is thicker than the thickness of the porous body in the first region and is thinner than the thickness of the porous body in the second region.
  • the porous body according to any one of [7].
  • a porous body including a through hole arrangement portion having a plurality of through holes;
  • a filter device comprising: a support body that is laminated on at least one of the porous bodies in the thickness direction and has at least one opening; The at least one opening of the support is arranged to expose at least one of the plurality of through holes;
  • a partial region of the through hole arrangement portion is defined as a first region, includes an outer peripheral edge of the through hole arrangement portion, and is on the outer peripheral side than the first region
  • a part of the through hole arrangement portion located at the second region is a second region, and in the plan view viewed from the thickness direction of the porous body, the support body that overlaps the first region of the porous body When a part is a first part and a part of the support that overlaps the second region of the porous body is a second part, The volume occupancy of the constituent member of the support in the second part is higher than the volume occupancy of the constituent member of the support in the first part.
  • a partial region of the through hole arrangement portion located between the first region and the second region is a third region;
  • a part of the support that overlaps the third region of the porous body is a third portion,
  • the volume occupancy of the constituent member of the support in the third portion is higher than the volume occupancy of the constituent member of the support in the first portion, and the constituent member of the support in the second portion.
  • the filter device according to any one of [10] to [13], which is lower than the volume occupancy rate of.
  • An average opening diameter of the at least one opening in the third portion is longer than an average opening diameter of the at least one opening in the first portion, and the at least one opening in the second portion.
  • the thickness of the support in the third portion is thicker than the thickness of the support in the first portion and thinner than the thickness of the support in the second portion.
  • the present invention it is possible to provide a porous body and a filter device that are not easily deformed or damaged while realizing high measurement sensitivity and reduced pressure loss.
  • FIG. 1 is a schematic diagram illustrating a configuration of a porous body according to Embodiment 1.
  • FIG. (A) is a top view
  • (b) is a side view.
  • 3 is a schematic plan view for explaining the configuration of a porous body according to Embodiment 1.
  • FIG. 6 is a schematic diagram for explaining a configuration of a porous body according to Embodiment 2.
  • FIG. (A) is a top view
  • (b) is a sectional view.
  • 6 is a schematic plan view showing a configuration of a porous body according to Embodiment 3.
  • FIG. It is a schematic perspective view which shows the structure of the porous body of Embodiment 3.
  • 10 is a schematic plan view for explaining a configuration of a modified example of the porous body of Embodiment 3.
  • FIG. It is a schematic diagram for demonstrating the stress which arises in a porous body in the case of filtration. It is another schematic diagram for demonstrating the stress which arises in
  • each embodiment is an illustration, and it cannot be overemphasized that the partial substitution or combination of the structure shown in different embodiment is possible.
  • description of matters common to the first embodiment is omitted, and only different points will be described. In particular, the same operation effect by the same configuration will not be sequentially described for each embodiment.
  • FIG. 1 is a schematic diagram illustrating a configuration of a porous body 1 according to the first embodiment.
  • the porous body 1 of the present embodiment is a film-like structure including a through hole arrangement portion 11 having a plurality of through holes 110.
  • the porous body 1 in the present embodiment has a first main surface 1a and a second main surface 1b facing the first main surface 1a.
  • the through hole 110 penetrates from the first main surface 1a toward the second main surface 1b. That is, the through hole 110 penetrates in the thickness direction of the porous body 1. Note that the thickness of the porous body 1 shown in FIG. 1 is constant.
  • porous body 1 has an outer peripheral portion 12 around a through hole arrangement portion 11.
  • the outer peripheral part 12 becomes a part pinched by the fixing member, for example.
  • the porous body 1 including its surface is formed of a conductor, and it is more preferable that the entire porous body 1 is formed of a conductor.
  • the conductor is an object (material) that conducts electricity, and includes not only metals but also semiconductors.
  • metal examples include nickel, gold, silver, copper, platinum, iron, chromium, stainless steel, titanium, and alloys thereof. Preferred are nickel, gold, platinum and titanium, and more preferred are nickel and gold.
  • semiconductors examples include group IV semiconductors (Si, Ge, etc.), group II-VI semiconductors (ZnSe, CdS, ZnO, etc.), group III-V semiconductors (GaAs, InP, GaN, etc.), group IV compounds, and the like.
  • Compound semiconductors such as semiconductors (SiC, SiGe, etc.), I-III-VI group semiconductors (CuInSe 2 etc.), and organic semiconductors can be mentioned.
  • interval of the through-hole 110 is large from the inner side of the through-hole arrangement
  • a partial region of the through-hole arranging portion 11 is defined as a first region 111, and the outer peripheral edge 11 a of the through-hole arranging portion 11 is defined as A partial region of the through hole arrangement portion 11 that is included on the outer peripheral side of the first region 111 is a second region 112.
  • the volume occupation ratio of the constituent members of the porous body 1 in the second region 112 is higher than the volume occupation ratio of the constituent members of the porous body 1 in the first region 111.
  • the “plan view as viewed from the thickness direction of the porous body 1” may be simply referred to as “plan view”.
  • the thickness direction of the porous body 1 corresponds to the normal direction of the first main surface 1a (or the second main surface 1b).
  • the outer peripheral part 12 is abbreviate
  • the volume occupancy rate of the constituent members of the porous body 1 in the first region 111 is the highest in the thickness direction of the porous body 1 among the planes perpendicular to the thickness direction of the porous body 1 in the first region 111. This is the ratio of the volume occupied by the structural member (portion other than the through-hole 110) of the porous body 1 to the volume of the space sandwiched between the first plane in contact with the high position and the second plane in contact with the lowest position.
  • the volume occupancy rate of the constituent members of the porous body 1 in the second region 112 is the highest in the thickness direction of the porous body 1 among the planes perpendicular to the thickness direction of the porous body 1 in the second region 112. This is the ratio of the volume occupied by the constituent members of the porous body 1 to the volume of the space sandwiched between the first plane in contact with the high position and the second plane in contact with the lowest position.
  • the first plane corresponds to the first main surface 1a
  • the second plane corresponds to the second main surface 1b.
  • the area occupancy rate of the constituent members of the porous body 1 in the second region 112 in the plan view viewed from the thickness direction of the porous body 1 is the porous body in the first region 111. It can be said that it is higher than the area occupancy rate of one constituent member.
  • the flow velocity of the fluid in the flow path is faster on the flow path center side and slower on the flow path outer peripheral side.
  • the flow velocity is distributed in a parabolic shape in the radial direction in the longitudinal cross section of the flow channel, and the maximum flow velocity at the center is 2 of the average flow velocity (volume flow rate / cross sectional area). Doubled.
  • the fluid that collides with the through hole arrangement portion 11 is not uniform in the through hole arrangement portion 11, and a high flow rate is present in the through hole arrangement portion 11 on the flow path center side.
  • the low-flow-rate fluid collides with the through-hole arrangement
  • the force F received from the fluid by the porous body 1 arranged in the flow path is indicated by a black arrow in FIG. As shown, it is large on the channel center side and small on the channel outer periphery side.
  • the volume occupancy of the constituent members of the porous body 1 and the area occupancy in the plan view are higher on the outer peripheral side than the inside of the through-hole arrangement portion 11 in the plan view.
  • the strength is higher on the outer peripheral side than on the inner side of the porous body 1 in plan view.
  • the aperture ratio of the through hole 110 is reduced on the outer peripheral side of the porous body 1, and the aperture ratio of the through hole 110 is increased inside the porous body 1.
  • porous body 1 of the present embodiment high measurement sensitivity and pressure loss can be reduced during filtration by both improving the film strength on the outer peripheral side and reducing the inner channel resistance. It is possible to provide the porous body 1 that is hardly deformed or broken while being realized.
  • the first region 111 is preferably a region including the center of gravity of the porous body 1.
  • the center of gravity of the porous body 1 corresponds to the center of the porous body 1.
  • the flow path resistance is reduced particularly at the center of gravity (center) side portion of the porous body 1 where the pressure received by the fluid is large, and the stress received from the fluid during filtration can be more effectively dispersed.
  • the first region 111 may be at a position where the pressure received by the fluid is large.
  • the first region 111 is a porous body in plan view. One centroid may not be included.
  • the average interval between the plurality of through holes 110 in the second region 112 in the plan view viewed from the thickness direction of the porous body 1 is the plurality of through holes in the first region 111. It can be said that the average interval is longer than 110.
  • the “average interval between through-holes 110” is the average value of the interval between each through-hole 110 and another through-hole 110 closest to the through-hole 110.
  • the “interval” is the shortest distance connecting the periphery of the gap and the periphery of the adjacent gap.
  • the shape of the through-hole 110 is a circle in plan view.
  • the average value of similar intervals is set for the circumscribed circle of the through-hole 110 in plan view. It is assumed that “the average interval of the through holes 110”.
  • the porous body 1 in the second region 112 is viewed in a plan view as viewed from the thickness direction of the porous body 1.
  • the area occupancy of the constituent members is higher than the area occupancy of the constituent members of the porous body 1 in the first region 111, and the same effect as described above is exhibited.
  • FIG. 1B if the thickness of the porous body 1 is constant, the volume occupancy rate of the constituent members of the porous body 1 in the second region 112 is that of the porous body 1 in the first region 111.
  • the volume occupancy of the constituent members is higher, and the same effect as described above is achieved.
  • the “size of the through hole 110” is the diameter of the circle when the shape of the through hole 110 in a plan view is a circle, and the through hole when the shape of the through hole 110 is a shape other than a circle.
  • the diameter of the circumscribed circle of the hole 110 is meant.
  • the volume occupancy of the constituent member of the porous body 1 in the third region 113 is higher than the volume occupancy of the constituent member of the porous body 1 in the first region 111,
  • the volume occupancy of the constituent members of the porous body 1 in the second region 112 is preferably lower.
  • the volume occupancy rate of the constituent members of the porous body 1 in the third region 113 is the highest in the thickness direction of the porous body 1 in the plane perpendicular to the thickness direction of the porous body 1 in the third region 113. This is the ratio of the volume occupied by the constituent members of the porous body 1 to the volume of the space sandwiched between the first plane in contact with the position and the second plane in contact with the lowest position.
  • the area occupancy of the constituent members of the porous body 1 in the third region 113 is more than the area occupancy of the constituent members of the porous body 1 in the first region 111. It is preferable that the area occupancy of the constituent member of the porous body 1 in the second region 112 is lower.
  • the average interval between the plurality of through holes 110 in the third region 113 is longer than the average interval between the plurality of through holes 110 in the first region 111,
  • the average interval between the plurality of through holes 110 in the second region 112 is preferably shorter.
  • At least one of the volume occupancy and area occupancy of the constituent members of the porous body 1 and the average interval of the through-holes 110 in three steps or more from the inner side to the outer peripheral side of the through-hole arrangement portion 11 in plan view. Is increasing. Thereby, compared with the case of two steps, it is more suitable for the pressure distribution of the fluid, and the pressure of the fluid applied to the porous body 1 can be efficiently dispersed.
  • the volume occupancy of the constituent members of the porous body 1 is increased stepwise in four or more stages, the fluid pressure applied to the porous body 1 can be more efficiently dispersed. .
  • each of the first region 111, the second region 112, and the third region 113 are not particularly limited, and may be the same or different.
  • each of the first region 111, the second region 112, and the third region 113 may be a region having the same area in plan view.
  • the sizes of the plurality of through holes 110 are approximately the same, by counting the number of through holes 110 included in each region, the volume occupancy and area of the constituent members of the porous body 1 in each region The occupation ratio and the average interval of the through holes 110 can be compared.
  • each of the first region 111, the second region 112, and the third region 113 may be a region having the same two or more (for example, 200) through holes 110.
  • the volume occupancy and area occupancy of the constituent members of the porous body 1 in each region and the average interval of the through holes 110 can be compared.
  • the porous body 1 of the present embodiment can be used as a filter (sieving) for collecting a target substance contained in a fluid (specimen).
  • the fluid is, for example, a gas or a liquid.
  • the target substance include inorganic substances, organic substances or composites thereof contained in a fluid, or microorganisms or cells.
  • the target object should just have a shape in the state which exists in the fluid, and may be not only solid but sol, gel, etc.
  • Examples of the inorganic substance, the organic substance, or a composite thereof in the gas include atmospheric PM (Particulate Matter) 2.5, SPM (Suspended Particulate Matter), PM10, and pollen.
  • PM2.5 is a particulate substance floating in the atmosphere, and has a particle diameter of approximately 2.5 ⁇ m or less.
  • the porous body 1 of the present embodiment can be applied to the collection of the following object.
  • the void-arranged structure of the above embodiment can be applied.
  • exosomes endoplasmic reticulum
  • the size of the exosome is about several hundred nm, and the porous body 1 of the above embodiment is applied to collect (filter and concentrate) only the exosome from a blood sample from which leukocytes, erythrocytes and other blood cells have been removed. be able to.
  • Capturing means, for example, physically holding the target object in the through-hole 110 of the porous body 1 or directly on the surface of the porous body 1 modified so that the target object is easily adsorbed. It refers to attaching a target object either manually or indirectly.
  • the size and shape of the plurality of through holes 110 of the porous body 1 may be constant, for example, at least one of the size and shape of the plurality of through holes 110 in the first region 111 and the second region 112. May be different.
  • the size of the plurality of through-holes 110 of the porous body 1 is not particularly limited as long as the target object can be collected.
  • the target object cannot physically pass or is difficult to pass. Is preferred.
  • the size of the through hole 110 defined as described above is preferably 100 ⁇ m or less, and more preferably 0.05 ⁇ m or more.
  • the opening ratio of the entire porous body 1 is preferably 3% or more, and more preferably 10% or more from the viewpoint of increasing the flow rate of the fluid passing through the porous body 1. Further, from the viewpoint of ensuring the strength of the porous body 1, the opening ratio in the entire porous body 1 is preferably 80% or less, and more preferably 60% or less.
  • the opening ratio is a ratio of the opening area of the through hole 110 to the entire area of the through hole arrangement portion 11 including the through hole 110 in plan view.
  • the average thickness of the porous body 1 is preferably as thin as possible within a range in which necessary mechanical strength can be maintained.
  • the average thickness of the porous body 1 is increased, generally the pressure loss when the fluid is passed increases. This is because when the pressure loss of the porous body 1 becomes large, the flow rate becomes slow and it becomes difficult to flow the fluid, so that there is a problem that the processing efficiency is lowered.
  • the measurement sensitivity is improved, and a smaller amount It becomes possible to measure an object to be measured.
  • the average thickness of the specific porous body 1 is preferably 0.2 ⁇ m or more and 40 ⁇ m or less, and more preferably 0.5 ⁇ m or more and 5 ⁇ m or less.
  • the porous body 1 of the present embodiment uses various known masks using a mask designed to form through holes 110 having a desired arrangement and shape, such as the porous body 1 described above. It can be manufactured by a lithography method or the like.
  • the surface of the porous body 1 used as a filter may be modified so that the target object is easily adsorbed.
  • the size of the through-hole 110 of the porous body 1 may be a size that allows the object to pass physically as long as the object can be collected chemically by this surface modification.
  • Examples of the modification such that the target product is easily adsorbed include coating with a substance having a high affinity for the target product.
  • a modification that binds a host molecule to the surface of the porous body 1 may be performed so that the target substance is bound to the host molecule.
  • the host molecule is a molecule that can specifically bind the target substance.
  • Examples of the combination of the host molecule and the target substance include an antigen and an antibody, a sugar chain and a protein, a lipid and a protein, Examples include molecular compounds (ligands) and proteins, proteins and proteins, single-stranded DNA and single-stranded DNA, and the like.
  • the thickness of the porous body 1 of the present embodiment is not constant, and the thickness of the porous body 1 in the second region 112 is larger than the thickness of the porous body 1 in the first region 111. It differs from the porous body 1 of Embodiment 1 by a thick point.
  • the first region 111 and the second region 112 are the same as in the first embodiment (see FIG. 2).
  • the outer peripheral part 12 is abbreviate
  • the area occupancy of the porous body 1 may be substantially the same on the inner side and the outer peripheral side of the through hole arrangement portion 11 in plan view. .
  • the volume occupancy rate of the constituent members of the porous body 1 is the through-hole arrangement portion 11 in plan view. It becomes higher on the outer peripheral side than on the inner side.
  • strength can be made higher on the outer peripheral side rather than the inner side of the porous body 1 in planar view.
  • positioning part 11 of the porous body 1 is not a plane.
  • the volume occupancy rate of the constituent members of the porous body 1 in the first region 111 is the highest in the thickness direction of the porous body 1 among the planes perpendicular to the thickness direction of the porous body 1 in the first region 111.
  • This is the ratio of the volume occupied by the constituent members (portions other than the through holes 110) of the porous body 1 to the volume of the space sandwiched between the first plane 1c in contact with the high position and the second plane in contact with the lowest position.
  • the second plane corresponds to the second major surface 1b, but the first plane does not correspond to the first major surface 1a.
  • the porous body 1 of the present embodiment even when the area occupancy of the porous body 1 is substantially the same on the inner side and the outer peripheral side of the through hole arrangement portion 11 in plan view, the porous body 1 of the present embodiment. Then, since the thickness of the porous body 1 is higher on the outer peripheral side than the inner side, the length of the through-hole 110 (the length in the thickness direction of the porous body 1) is higher on the inner side than the outer peripheral side of the porous body 1 in plan view. It is getting shorter. Thereby, the flow path resistance by the porous body 1 is reduced particularly in the inner portion where the pressure received by the fluid is large, and the stress received from the fluid during filtration can be effectively dispersed.
  • both the improvement in the film strength on the outer peripheral side and the reduction in the inner channel resistance achieve a high measurement sensitivity and a reduction in pressure loss, It becomes possible to provide the porous body 1 which is not easily damaged.
  • the thickness of the porous body 1 in the third region 113 is preferably larger than the thickness of the porous body 1 in the first region 111 and thinner than the thickness of the porous body 1 in the second region 112. Note that the third region 113 is the same as that of the first embodiment, and the effect thereof is also the same.
  • FIG. 3 shows a case where the area occupancy of the porous body 1 is substantially the same on the inner side and the outer peripheral side of the through hole arrangement portion 11 in a plan view, but the porous body is the same as in the first embodiment (FIG. 1).
  • the volume occupancy rate of the component 1 and the area occupancy rate in the plan view may be higher on the outer peripheral side than the inside of the through-hole arranging portion 11 in the plan view.
  • the filter device of the present embodiment includes (1) a membrane-like porous body 1 including a through-hole arrangement portion 11 having a plurality of through-holes 110, and (2) a porous body 1.
  • the support body 2 is laminated on at least one of the first main surface and the second main surface and has at least one opening 21.
  • the opening 21 does not necessarily have a closed outer shape such as a square or a circle in a plan view as viewed from the thickness direction of the porous body 1, and may be a notch or the like.
  • At least one opening 21 of support 2 is arranged to expose at least one of a plurality of through holes 110.
  • the through hole 110 of the porous body 1 is omitted.
  • a partial region of the through hole arrangement portion 11 is defined as a first region 111 in the plan view seen from the thickness direction of the porous body 1, and the outer peripheral edge 11 a of the through hole arrangement portion 11.
  • a partial region of the through-hole arrangement portion 11 located on the outer peripheral side of the through-hole arrangement portion 11 with respect to the first region 111 is defined as a second region 112 (see FIG. 2).
  • a part of the support 2 that overlaps the first region 111 of the porous body 1 in the plan view as viewed from the thickness direction of the porous body 1 is defined as a first portion
  • the second of the porous body 1 A part of the support 2 that overlaps the region 112 is defined as a second part.
  • the filter device of the present embodiment is characterized in that the volume occupancy of the constituent members of the support 2 in the second portion is higher than the volume occupancy of the constituent members of the support 2 in the first portion. It is said. That is, the volume occupation ratio of the constituent members of the support 2 is higher on the outer peripheral side than the inside of the support 2 in plan view.
  • the area occupancy rate of the constituent members of the support 2 in the second portion in the plan view viewed from the thickness direction of the porous body 1 is the configuration of the support 2 in the first portion. It can be said that it is higher than the area occupancy of the member. That is, the area occupancy rate of the constituent members of the support 2 is higher on the outer peripheral side than on the inner side of the support 2 in plan view.
  • the average opening diameter of at least one opening 21 in the second portion in a plan view seen from the thickness direction of the porous body 1 is It is shorter than the average opening diameter of at least one opening 21 in the first portion. That is, the average opening diameter of the opening 21 of the support 2 is shorter on the outer peripheral side than the inside of the support 2 in plan view.
  • the “average opening diameter of the openings 21” is the number average value of the opening diameters of the openings 21.
  • the opening diameter of the opening 21 is the pitch P of the crosspieces 2a of the support 2 shown in FIG.
  • the inner side of the support body 2 in plan view is increased by increasing the width of the constituent member (the crosspiece 2a) of the support body 2 on the outer peripheral side than the inside of the support body 2 in plan view. From the outer peripheral side to the outer peripheral side, the volume occupancy and area occupancy of the constituent members of the support 2 may be increased, and the average opening diameter of the openings 21 may be shortened. In FIG. 6, only one crosspiece 2 a constituting the support body 2 is displayed, and other portions of the support body 2 are omitted.
  • the support body 2 Since the support body 2 has such a configuration, the volume occupancy rate of the constituent members of the porous body 1 and the area occupancy rate in the plan view are the through-hole arrangement portions in the plan view. The effect similar to the effect by becoming higher on the outer peripheral side than the inner side of 11 is exhibited. That is, both the improvement of the membrane strength on the outer peripheral side of the support 2 and the reduction of the inner channel resistance realize high measurement sensitivity and reduction of pressure loss, and deformation and breakage hardly occur during filtration.
  • the porous body 1 can be provided.
  • the thickness of the support 2 in the second portion may be larger than the thickness of the support 2 in the first portion.
  • the porous body 1 according to the second embodiment has the same effect as that obtained by increasing the thickness of the porous body 1 from the inner side to the outer peripheral side.
  • the first region 111 is a portion including the center of gravity of the porous body 1 (the center of the porous body 1 in the present embodiment) when viewed from the thickness direction of the porous body 1. It is preferable. In this case, in plan view, the flow path resistance is reduced by the portion of the support 2 corresponding to the center of gravity (center) side portion of the porous body 1 where the pressure received by the fluid is particularly large, and the stress received from the fluid during filtration is further increased. It can be dispersed effectively.
  • a partial region of the through-hole arrangement portion 11 located between the first region 111 and the second region 112 is defined as a third region 113
  • the part of the support 2 that overlaps the third region 113 of the porous body 1 in the plan view as viewed from the thickness direction of the porous body 1 is defined as the third portion, the following condition is preferably satisfied. .
  • the volume occupation ratio of the constituent members of the support 2 in the third portion is higher than the volume occupation ratio of the constituent members of the support 2 in the first portion. It is preferably lower than the volume occupancy.
  • the area occupancy of the constituent members of the support 2 in the third portion is higher than the area occupancy of the constituent members of the support 2 in the first portion.
  • the area occupancy of the constituent members of the support 2 in the second portion is preferably lower.
  • the average opening diameter of at least one opening 21 in the third portion is longer than the average opening diameter of at least one opening 21 in the first portion. It is preferable that the average opening diameter of at least one opening 21 in the second portion is shorter.
  • the thickness of the support 2 in the third portion is preferably thicker than the thickness of the support 2 in the first portion and thinner than the thickness of the support 2 in the second portion.
  • At least one of the volume occupancy, area occupancy, and thickness of the constituent members of the support 2 and the average opening diameter of the openings 21 changes stepwise from the inside to the outside in plan view in three or more steps. Will do.
  • it is more suitable for the pressure distribution of the fluid and the pressure of the fluid applied to the porous body 1 can be efficiently dispersed.
  • the volume occupancy of the constituent members of the porous body 1 is increased stepwise in four or more stages, the fluid pressure applied to the porous body 1 can be more efficiently dispersed. .
  • the support body 2 of the filter device according to the present embodiment will be mainly described.
  • the porous body 1 of the filter device according to the present embodiment the porous body 1 is different from the first and second embodiments in FIGS. The case where it is a form (form in which the area occupation rate of the porous body 1 is substantially the same on the inner side and the outer peripheral side of the through-hole arrangement part 11 in a plan view) is shown.
  • the porous body 1 may be the porous body 1 of Embodiment 1 or 2, and in this case, the effect of the support 2 of the present embodiment is further enhanced by the effect of the porous body 1 of Embodiment 1 or 2. Is done.
  • the combination of the material of the porous body 1 and the support body 2 is not particularly limited, but from the viewpoint of obtaining uniform characteristics as the entire porous body 1, a combination of the same kinds of materials is preferable.
  • the filter device of this embodiment manufactures the porous body 1 by a well-known various lithography method etc. using the mask by which pattern design was carried out, for example, on the porous body 1 like said support body 2 above. It can be manufactured by laminating the support 2 by various known lithography methods using a mask that is designed so that the openings 21 having a desired arrangement and shape are formed.
  • SYMBOLS 1 Porous body, 1a 1st main surface, 1b 2nd main surface, 1c 1st plane, 11 through-hole arrangement

Abstract

La présente invention concerne un corps poreux sous forme de membrane qui comprend une partie de placement formant trou traversant ayant une pluralité de trous traversants ; lorsque le corps poreux vu en plan dans le sens de l'épaisseur présente définie à l'intérieur de celui-ci une première région qui fait partie de la partie de placement formant trou traversant, et une seconde région qui fait partie de la partie de placement formant trou traversant qui est positionnée davantage vers le côté périphérique extérieur par rapport à la première région et qui comprend le bord périphérique extérieur de la partie de placement formant trou traversant, le volume occupé par l'élément constitutif du corps poreux dans la deuxième région est supérieur au volume occupé par l'élément constitutif du corps poreux dans la première région.
PCT/JP2016/053089 2015-03-03 2016-02-02 Corps poreux et dispositif de filtre WO2016140005A1 (fr)

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WO2017141609A1 (fr) * 2016-02-15 2017-08-24 株式会社村田製作所 Filtre de filtration et dispositif de filtre de filtration
JP2018183133A (ja) * 2017-11-09 2018-11-22 株式会社村田製作所 有核細胞の濾過用フィルターおよびそれを用いた濾過方法
US10858624B2 (en) 2017-04-26 2020-12-08 Murata Manufacturing Co., Ltd. Filter for filtering nucleated cells and filtering method using the same
WO2022097295A1 (fr) * 2020-11-09 2022-05-12 三菱化工機株式会社 Module de séparation, dispositif de séparation, et système de séparation

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JP2007536071A (ja) * 2004-05-03 2007-12-13 フリースランド・ブランズ・ビー・ヴイ 担体上に膜を持つデバイス、そしてそのような膜を製造するための方法
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WO2017141609A1 (fr) * 2016-02-15 2017-08-24 株式会社村田製作所 Filtre de filtration et dispositif de filtre de filtration
US11052337B2 (en) 2016-02-15 2021-07-06 Murata Manufacturing Co., Ltd. Filtration filter and filtration filter device
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WO2022097295A1 (fr) * 2020-11-09 2022-05-12 三菱化工機株式会社 Module de séparation, dispositif de séparation, et système de séparation

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