WO2016130850A1 - Planification et commande pour radiothérapie guidée par résonance magnétique - Google Patents

Planification et commande pour radiothérapie guidée par résonance magnétique Download PDF

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Publication number
WO2016130850A1
WO2016130850A1 PCT/US2016/017618 US2016017618W WO2016130850A1 WO 2016130850 A1 WO2016130850 A1 WO 2016130850A1 US 2016017618 W US2016017618 W US 2016017618W WO 2016130850 A1 WO2016130850 A1 WO 2016130850A1
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WIPO (PCT)
Prior art keywords
radiation
delivery
mri
mrgrt
gates
Prior art date
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PCT/US2016/017618
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English (en)
Inventor
James F. Dempsey
Iwan Kawrykow
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Viewray Technologies, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Viewray Technologies, Inc. filed Critical Viewray Technologies, Inc.
Priority to AU2016219215A priority Critical patent/AU2016219215B2/en
Priority to EP16708028.2A priority patent/EP3256215B1/fr
Priority to KR1020177024908A priority patent/KR20170116070A/ko
Priority to JP2017542112A priority patent/JP6893876B2/ja
Priority to EP23201326.8A priority patent/EP4325235A3/fr
Priority to CN202210997198.XA priority patent/CN115337557A/zh
Priority to CN202011072387.3A priority patent/CN112043979B/zh
Priority to CN201680017015.6A priority patent/CN107427691B/zh
Priority to CA2976331A priority patent/CA2976331C/fr
Publication of WO2016130850A1 publication Critical patent/WO2016130850A1/fr
Priority to HK18105955.2A priority patent/HK1246229A1/zh

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048—Monitoring, verifying, controlling systems and methods
    • A61N5/1049—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/103—Treatment planning systems
    • A61N5/1037—Treatment planning systems taking into account the movement of the target, e.g. 4D-image based planning
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/103—Treatment planning systems
    • A61N5/1039—Treatment planning systems using functional images, e.g. PET or MRI
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048—Monitoring, verifying, controlling systems and methods
    • A61N5/1064—Monitoring, verifying, controlling systems and methods for adjusting radiation treatment in response to monitoring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048—Monitoring, verifying, controlling systems and methods
    • A61N5/1064—Monitoring, verifying, controlling systems and methods for adjusting radiation treatment in response to monitoring
    • A61N5/1069—Target adjustment, e.g. moving the patient support
    • A61N5/107—Target adjustment, e.g. moving the patient support in real time, i.e. during treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048—Monitoring, verifying, controlling systems and methods
    • A61N5/1071—Monitoring, verifying, controlling systems and methods for verifying the dose delivered by the treatment plan
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/4808—Multimodal MR, e.g. MR combined with positron emission tomography [PET], MR combined with ultrasound or MR combined with computed tomography [CT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048—Monitoring, verifying, controlling systems and methods
    • A61N5/1049—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
    • A61N2005/1055—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam using magnetic resonance imaging [MRI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048—Monitoring, verifying, controlling systems and methods
    • A61N5/1071—Monitoring, verifying, controlling systems and methods for verifying the dose delivered by the treatment plan
    • A61N2005/1072—Monitoring, verifying, controlling systems and methods for verifying the dose delivered by the treatment plan taking into account movement of the target

Definitions

  • the subject matter described herein relates to radiation therapy and more particularly to magnetic resonance guided radiation therapy (MRgRT).
  • MRgRT magnetic resonance guided radiation therapy
  • Radiation therapy is frequently used to control and eliminate malignant cells in a patient.
  • a cancerous tumor can be exposed to radiation (e.g., X-rays, gamma rays, and charged particles) during one or more treatment sessions.
  • radiation e.g., X-rays, gamma rays, and charged particles
  • ROI region of interest
  • the radiation should be delivered in a manner that spares organs at risk (OARs).
  • radiation therapy treatments are planned and administered based on the contours and positions of ROIs and OARs as defined in static medical imaging scans (e.g., computed tomography (CT), magnetic resonance imaging (MRI)).
  • CT computed tomography
  • MRI magnetic resonance imaging
  • conventional radiation therapy does not account for patient motion during treatment.
  • patient organ geometry may shift significantly during treatment due to voluntary and/or involuntary movements (e.g., respiration, muscle contractions). Consequently, the actual dose of radiation delivered to the ROI and the extent to which OARs are subject to radiation are likely to deviate from the intended treatment plan.
  • conventional radiation therapy can be less effective than desirable.
  • Implementations of the current subject matter improve the administration of radiation therapy including by simultaneously delivering radiation and performing MRI.
  • the delivery of radiation can be controlled based on patient motion indicated by MRI images captured during the delivery or radiation.
  • One or more mechanisms can be deployed during the delivery of radiation to terminate radiation delivery based on patient motion.
  • Implementations of the current subject matter include a method for MRgRT.
  • the method can include: simultaneously using one or more radiation therapy heads to deliver radiation and an MRI system to perform MRI; using a processor to determine whether one or more gates are triggered based on at least a portion of MRI images captured during the delivery of radiation; and in response to determining that one or more gates are triggered based on at least a portion of the MRI images captured during the delivery of radiation, suspending the delivery of radiation.
  • Implementations of the current subject matter include a system for MRgRT.
  • the system can include an MRgRT apparatus and a processor coupled to the MRgRT apparatus.
  • the MRgRT apparatus can include one or more radiation therapy heads and an MRI system.
  • the MRgRT apparatus can be configured to simultaneously use the one or more radiation therapy heads to deliver radiation and the MRI system to perform MRI.
  • the processor can be configured to: determine whether one or more gates are triggered based on at least a portion of MRI images captured during the delivery of radiation; and in response to determining that one or more gates are triggered based on at least a portion of the MRI images captured during the delivery of radiation, suspend the delivery of radiation.
  • Implementations of the current subject matter include a method for MRgRT.
  • the method can include: receiving a plurality of MRI images captured by an MRI system during a delivery of radiation by one or more radiation therapy heads; determining, based on a least a portion of the MRI images, whether one or more gates are triggered; and in response to determining that the one or more gates are triggered based on at least a portion of the MRI images, causing the one or more radiation therapy heads to suspend delivery of radiation.
  • Implementations of the current subject matter can include, but are not limited to, methods consistent with the descriptions provided herein as well as articles that comprise a tangibly embodied machine-readable medium operable to cause one or more machines (e.g., computers, etc.) to result in operations implementing one or more of the described features.
  • machines e.g., computers, etc.
  • computer systems are also described that may include one or more processors and one or more memories coupled to the one or more processors.
  • a memory which can include a non-transitory computer-readable or machine-readable storage medium, may include, encode, store, or the like one or more programs that cause one or more processors to perform one or more of the operations described herein.
  • Computer implemented methods consistent with one or more implementations of the current subject matter can be implemented by one or more data processors residing in a single computing system or multiple computing systems. Such multiple computing systems can be connected and can exchange data and/or commands or other instructions or the like via one or more connections, including but not limited to a connection over a network (e.g. the Internet, a wireless wide area network, a local area network, a wide area network, a wired network, or the like), via a direct connection between one or more of the multiple computing systems, etc.
  • a network e.g. the Internet, a wireless wide area network, a local area network, a wide area network, a wired network, or the like
  • FIG. 1 is a network diagram illustrating an MRgRT system consistent with implementations of the current subject matter
  • FIG. 2 is a cross-sectional view illustrating an MRgRT apparatus consistent with implementations of the current subject matter
  • FIG. 3 illustrates a series of MRI images consistent with implementations of the current subject matter
  • FIG. 4A illustrates the delivery of one or more radiation beams consistent with implementations of the current subject matter
  • FIG. 4B illustrates the delivery of one or more radiation beams consistent with implementations of the current subject matter
  • FIG. 5 is a flowchart illustrating an MRgRT process consistent with implementations of the current subject matter
  • FIG. 6 is a flowchart illustrating a process for treatment planning consistent with implementations of the current subject matter
  • FIG. 7 is a flowchart illustrating a process for administering radiation therapy consistent with implementations of the current subject matter
  • FIG. 8 is a flowchart illustrating a process for dose computation consistent with implementations of the current subject matter.
  • FIG. 9 is a flowchart illustrating a process for administering radiation therapy consistent with implementations of the current subject matter.
  • Various implementations of the current subject matter can include systems and methods for MRgRT that provide dynamic controls for the delivery of radiation.
  • Implementations of the current subject matter can include a gating mechanism which imposes one or more spatial and/or temporal gates for controlling the delivery of radiation.
  • Some implementations of the current subject matter can further include an interlock mechanism, which detects gross patient movement and suspends radiation delivery accordingly.
  • Gating and interlock mechanisms consistent with the present disclosure can operate based on MRI images (e.g., planar, volumetric) including MRI images captured during the delivery of radiation.
  • FIG. 1 is a system diagram illustrating an MRgRT system 100 consistent implementations of the current subject matter.
  • the MRgRT system 100 can include a system controller 112, a gantry 120, a radiation therapy head 122, a patient couch 124, a multi-leaf collimator 126, and an MRI system 128.
  • the system controller 112 is configured to control the operations of the gantry 120, the radiation therapy head 122, the patient couch 124, the multi-leaf collimator 126, and the MRI system 128.
  • the system controller 1 12 can be coupled to a control console 114. Via the control console 114, a user may control the operations of the system controller 1 12 thereby controlling the operations of one or more of the gantry 120, the radiation therapy head 122, the patient couch 124, the multi-leaf collimator 126, and the MRI system 128.
  • the radiation therapy head 122 may deliver one or more beams of radiation.
  • the system controller 112 may rotate the gantry 120 and/or the patient couch 124 such that a patient on the patient couch 124 is properly positioned to receive the radiation beams (e.g., at an ROI) from the radiation therapy head 122.
  • the radiation therapy head 122 can be implemented by any device that can be a source of radiation or a linear particle accelerator (LINAC) without departing from the scope of the present disclosure.
  • the radiation therapy head 122 can be a radioisotope source using isotopes including, for example, but not limited to, cobalt (e.g., cobalt-60 ( Co)) and iridium (e.g., iridium- 192 ( Ir)).
  • the radiation therapy head 122 can also provide particle therapy as an LINAC.
  • the M g T system 100 is shown to include a single radiation therapy head, the MRgRT system 100 can include additional radiation therapy heads without departing from the scope of the present disclosure.
  • the MRgRT system 100 may administer intensity modulated radiation therapy (IMRT) or conformal radiation therapy (CRT).
  • the system controller 112 may engage the multi-leaf collimator 126.
  • the multi-leaf collimator 126 includes a plurality of "leaves" of heavy metal material (e.g., lead (Pb), tungsten (W)) that alter the shape of the radiation beam from the radiation therapy head 122 by blocking at least some portions of the radiation beam.
  • the shape of the radiation beam can be adjusted (e.g., via the system controller 112) by changing the configuration of the leaves in the multi-leaf collimator 126.
  • references to radiation therapy throughout the present disclosure contemplates a variety of different types and forms of radiation therapy including, for example, but not limited to, IMRT and CRT.
  • the system controller 112, the control console 114, the gantry 120, the radiation therapy head 122, the patient couch, the multi-leaf collimator 126, and the MRI system 128 can be part of an MRgRT apparatus 1 10 capable of simultaneously delivering radiation and performing MRI.
  • the MRgRT apparatus 110 is described in further detail in co-owned Patent No. 7,907,987, the disclosure of which is incorporated herein by reference in its entirety.
  • the MRI system 128 captures planar (i.e., 2-dimensional (2D)) and/or volumetric (i.e., 3-dimensional (3D)) MRI images.
  • the MRI system 128 can be configured to capture MRI images of the patient during the delivery of radiation.
  • the MRI system 128 can also capture MRI images as part of motion-based treatment planning and throughout the course of radiation therapy treatment.
  • the MRI system 128 may capture planar and/or volumetric MRI images at a certain rate (e.g., 4 frames per second).
  • a sequential series of planar and/or volumetric MRI images captured by the MRI system 128 during the delivery of radiation enables tracking of patient motions (e.g., shift in patient organ geometry) during the delivery of radiation.
  • the MRI system 128 can store such data (e.g., 4-dimensional (4D) MRI image data) in a first data store 142.
  • the MRgRT system 100 includes a user interface system 130.
  • the user interface system 130 can provide one or more input/output (I/O) mechanisms including, for example, but not limited to, a display 132, a scanner 134, a printer 136, and a security reader 138.
  • I/O input/output
  • a user e.g., a radiotherapist
  • the user can be authenticated to access the MRgRT system 100 via the security reader 138 using one or more mechanisms including, for example, but not limited to, biometrics and radio frequency identification (RFED) tags.
  • RFED radio frequency identification
  • the user can also configure the MRgRT system 100 via the user interface system 130 to perform one or more operations associated with the administration of radiation therapy including, for example, but not limited to, treatment planning, execution, and optimization.
  • the MRgRT system 100 can further include a processor 150, which can monitor for when gates are triggered and/or when interlock thresholds are exceeded based on MRI images (e.g., 4D) captured by the MRI system 128 during radiation delivery.
  • the processor 150 can also be configured to generate and/or modify one or more treatment plans.
  • the processor 150 can calculate the actual dose of radiation that was delivered a patient during a radiation therapy treatment session based on the MRI images captured during the delivery of radiation.
  • the actual dose of radiation that was delivered to the patient can be affected by patient motion (e.g., change in patient organ geometry) during the delivery of radiation as well as interruptions to radiation delivery caused by the gating mechanism and/or the interlocking mechanism.
  • the MRgRT system 100 can also be configured to track the cumulative dose of radiation delivered to a patient. As such, the processor 150 may accrue the actual dose of radiation delivered to a patient during individual radiation therapy treatment sessions.
  • the MRgRT system 100 can provide a patient monitoring and communication system 162.
  • the patient monitoring and communication system 162 can include a camera and/or a microphone.
  • the MRgRT system 100 can further include a patient audio/video (A/V) entertainment system 164.
  • the patient A V entertainment system 164 can be portable electronic device such as a tablet personal computer (PC).
  • the MRgRT system 100 supports access by a plurality of remote users including, for example, but not limited to, a first remote user 192, a second remote user 194, and a third remote user 196.
  • Remote users may access the MRgRT system 100 via a wired and/or wireless network 170 to perform tasks including, for example, but not limited to, radiation therapy treatment planning, approvals, and scheduling.
  • Access to the MRgRT system 100 by remote users can be monitored and regulated by a firewall 180.
  • the MRgRT system 100 can include additional and/or different components than shown without departing from the scope of the present disclosure.
  • FIG. 2 is a cross-sectional view illustrating the MRgRT apparatus 1 10 consistent with implementations of the current subject matter.
  • the MRgRT apparatus 1 10 includes the gantry 120, the multi-leaf collimator 126, the patient couch 124, and the MRI system 128. Consistent with implementations of the current subject matter, a patient 200 can be placed on the patient couch 124. The patient 200 can receive radiation from the radiation therapy head 122 while the MRI system 128 simultaneously captures one or more MRI images of the patient 200.
  • the MRgRT apparatus 1 10 can include additional and/or different components than shown without departing from the scope of the present disclosure.
  • FIG. 3 illustrates a series 300 of MRI images consistent with implementations of the current subject matter.
  • the series 300 of MRI images depict patient motion, such as during the delivery of radiation.
  • the MRgRT system 100 e.g., the MRI system 128, can capture the MRI images of the series 300 as part of motion-based treatment planning, while a patient is undergoing radiation therapy, and/or throughout the course of radiation therapy treatment.
  • the series 300 includes a first MRI image 310, a second MRI image 320, a third MRI image 330, and a fourth MRI image 340.
  • a change in the patient's organ geometry resulting from a muscle contraction is depicted in the first MRI image 310 and the second MRI image 320.
  • a contraction of the patient's gluteus muscles results in a shift in the position of the bladder 352.
  • a change in the patient's organ geometry resulting from respiration is depicted in the third MRI image 330 and the fourth MRI image 340.
  • taking a breath causes a shift in the positions of the bladder 352, the prostate 354, and the rectum 356.
  • FIG. 4A illustrates the delivery of one or more radiation beams consistent with implementations of the current subject matter.
  • a patient's radiation therapy treatment can include delivering a plurality of radiation beams to an ROI 410, including, for example, a first radiation beam 422 and a second radiation beam 424.
  • the patient's radiation therapy treatment can be planned by placing the first radiation beam 422 and the second radiation beam 424 such that the ROI 410 is subject to maximum exposure to the first radiation beam 422 and the second radiation beam 424.
  • the patient's radiation therapy treatment can be planned by placing the first radiation beam 422 and the second radiation beam 424 such that a first OAR 432 and a second OAR 434 are subject to minimal exposure to the first radiation beam 422 and the second radiation beam 424.
  • FIG. 4B illustrates the delivery of one or more radiation beams consistent with implementations of the current subject matter.
  • patient motion during radiation therapy can change patient organ geometry and cause the delivery of radiation beams to deviate from the treatment plan.
  • patient motion during radiation therapy may cause the ROI 410 to shift outside of the paths of the first radiation beam 422 and the second radiation beam 424 as placed in accordance with the treatment plan.
  • patient motion during radiation therapy may cause the second OAR 434 to shift into the paths of the first radiation beam 422 and the second radiation beam 434 as placed in accordance with the treatment plan.
  • the actual dose of radiation delivered to the ROI 410 is less than planned while the second OAR 434 is exposed to a higher dose of radiation than planned.
  • FIG. 5 is a flowchart illustrating an MRgRT process 500 consistent with implementations of the current subject matter.
  • the MRgRT process 500 can be performed by the MRgRT system 100 described with respect to FIG. 1.
  • the MRgRT system 100 performs system calibration (502). For example, a calibrated output of the radiation therapy head 122 and measured radiation therapy calibration data can be input into the MRgRT system 100 when installing, commissioning, reconfiguring, and/or updating the MRgRT system 100.
  • data for calibrating the MRI system 128 can also be acquired and/or computed.
  • Data for calibrating the MRgRT system 100 including the MRI system 128 can include, for example, but not limited to, dosimetric output of cobalt sources (e.g.
  • the user interface 130 can be configured to display at least a portion of the calibration data in overlay, percent difference, and absolute difference. Additionally, the MRgRT system 100 can also store the calibration data (e.g., in the first data store 142 and/or the second data store 144) and/or output the calibration data (e.g., via the printer 136). Integrity of the calibration data can be ensured by storing redundant copies of the calibration data and/or applying a cyclically redundant checksum algorithm.
  • the MRgRT system 100 can register a user (504).
  • a user e.g., a radiotherapist
  • User registration can include recording one or more forms of identification information including, for example, but not limited to, username, password, photograph, and biometrics.
  • At least some users can be defined as administrative users having the capability to set privileges and tasks for other users with respect to the MRgRT system 100.
  • Access to the MRgRT system 100 can require successful user registration and authentication.
  • a user can bypass user registration and/or authentication by providing one or more forms of identification information including, for example, but not limited to, a photograph and biometrics.
  • the MRgRT system 100 can register a patient (506).
  • a patient can be required to register in order to undergo medical imaging and/or radiation therapy treatments administered by the MRgRT system 100.
  • Patient registration can include recording one or more forms of identification information including, for example, but not limited to, patient name, password, photograph, and biometrics.
  • patient registration can include collecting personal data including, for example, but not limited to, age, date of birth, gender, weight, race, address, medical data, treatment instructions, contact information, and A/V entertainment preferences.
  • the MRgRT system 100 can require patient authentication based on identification information including, for example, but not limited to, patient name, date of birth, social security number, photo identification, and biometrics.
  • identification information including, for example, but not limited to, patient name, date of birth, social security number, photo identification, and biometrics.
  • patient registration and/or authentication can be bypassed.
  • treatment planning includes a plurality of operations including, for example, but not limited to, MRI image acquisition, contouring (e.g., of ROIs and/or OARs), prescription, and delivery configuration.
  • the planned treatment can include IMRT.
  • treatment planning can further include EVIRT configurations.
  • a gating mechanism can be deployed during radiation delivery.
  • the gating mechanism monitors the positions of anatomical structures (e.g., ROIs and/or OARs) using MRI images captured by the MRgRT system 100 (e.g., the MRI system 128) during the delivery of radiation and suspends radiation delivery based on spatial and/or temporal "gates."
  • the gating mechanism can be configured to suspend radiation delivery in the event that an ROI or an OAR shifts and remains across of one or more spatial gates (e.g., 3 millimeters (mm)) for a length of time in excess of the temporal gate (e.g., 3 seconds).
  • the first treatment plan can include definitions of one or more spatial and/or temporal gates.
  • One or more spatial gates can be defined based on a baseline set of MRI images depicting the default or resting positions of a patient's anatomical structures (e.g., OIs and/or OARs).
  • the MRgRT system 100 can provide, via the user interface 130, a graphic user interface (GUI) for a user (e.g., a radiologist) to indicate the position of one or more spatial gates on the baseline set of MRI images.
  • GUI graphic user interface
  • one or more spatial gates can be set based on a patient's treatment plan (e.g., the first treatment plan) to indicate a region that is expected to receive a high dose of radiation.
  • the user can set one or more spatial gates based on overlap between the patient's anatomical structures (e.g., ROIs and OARs) as depicted in the MRI images and those regions expecting to receive high radiation doses.
  • the MRgRT system 100 can provide tools to enables the user to visually set one or more spatial gates based on planar or volumetric representations of ROIs (e.g., generated based on the MRI images) and/or regions expecting to receive high doses of radiation.
  • a spatial gate can be set with fractional gating parameters such that the spatial gate is triggered based on a fractional or percentage overlap in a 2D or 3D region.
  • spatial gates ensure that an ROI is exposed to radiation only when the ROI is within the gated region subject to high radiation dose.
  • the gates can also ensure that an OAR is spared from being exposed to a high radiation dose when the OAR enters the gated region subject to high radiation dose.
  • the user can also set and assign temporal gates to one or more spatial gates.
  • the temporal gates impose a numerical time delay such that a spatial gate is triggered by patient motions (e.g., changes in patient organ geometry) that are maintained over a threshold period of time (e.g., 3 seconds).
  • an interlock mechanism can be deployed during radiation delivery.
  • the interlock mechanism is configured to suspend radiation delivery in response to detecting significant and/or excessive patient motion (e.g., change in patient organ geometry) in MRI images (e.g., planar) captured by during the delivery of radiation.
  • the first treatment plan can also include one or more thresholds triggering the interlock mechanism.
  • the interlock mechanism can operate based on fast numerical evaluations of image characteristics including, for example, but not limited to, image intensity (e.g., of MRI images).
  • image intensity e.g., of MRI images
  • the interlock mechanism can operate based on loss of image intensity (e.g. blank images), total change in pixel intensity between consecutive images or image sets, and/or large changes in variance between consecutive images or image sets. Changes in image intensity can indicate that the MRI system 128 is not operating correctly and/or rapid and excessive patient motion. Accordingly, the delivery of radiation can be terminated until the condition is resolved such as when rapid and excessive patient motion has ceased.
  • the MRgRT system 100 administers radiation therapy treatment to the patient based at least in part on the first treatment plan (510).
  • treatment administration can include a plurality of operations including, for example, but not limited to, initial and/or continued adjustments of patient position (e.g., on the patient couch 124), MRI, and radiation delivery.
  • the MRgRT system 100 simultaneously delivers radiation (e.g., via the radiation therapy head 122) and performs MRI (e.g., using the MRI system 128).
  • MRI images captured during radiation delivery can be used to detect patient motion.
  • the MRgRT system 100 can control the delivery of radiation to a patient based on patient motion detected during radiation delivery.
  • treatment administration can further include operations to recommence radiation delivery that has been suspended by the gating mechanism.
  • treatment administration can also include operations to recommence radiation delivery that has been suspended by the interlock mechanism.
  • the MRgRT system 100 can recommence radiation delivery when one or more conditions causing the suspension of radiation delivery has been resolved (e.g., cessation of patient motion, anatomical structure returns within spatial gates).
  • the MRgRT system 100 is configured to store (e.g., in the first data store 142 and/or the second data store 144) at least a portion of the data collected (e.g., MRI images captured by the MRI system 128) during radiation delivery. For example, data collected from a patient's earlier radiation therapy treatment sessions can be used to generate subsequent treatment plans for the patient.
  • the MRgRT system 100 computes an actual dose of radiation delivered to the patient based on MRI images captured during radiation therapy (512).
  • the actual dose of radiation delivered to the patient can be affected by patient motion (e.g., shift in patient organ geometry) during the delivery of radiation and interruptions to radiation delivery caused by the gating mechanism and/or the interlock mechanism.
  • the MRgRT system 100 can compute actual dose by performing deformable image registration to identify anatomical structures (e.g., ROIs, OARS) that demonstrated motion exceeding one or more thresholds during radiation delivery. Additionally, in some implementations of the current subject matter, the MRgRT system 100 can compute actual dosage by also identifying anatomical structures that were exposed to radiation. The MRgRT system 100 can generate one or more dose volume histograms (DVH) reflecting the actual dosage delivered to the patient.
  • anatomical structures e.g., ROIs, OARS
  • DVB dose volume histograms
  • the MRgRT system 100 generates a second treatment plan for the patient based on the actual dose of radiation delivered (514) Consistent with implementations of the current subject matter, the MRgRT system 100 can generate a second treatment plan for subsequent radiation therapy treatments based on the actual dose of radiation that was delivered to a patient during one or more previous radiation therapy treatments.
  • the second treatment plan can include changes to the prescription and/or delivery configuration indicated by the first treatment plan including, for example, but not limited to, increasing radiation dose to an ROI that received insufficient doses of radiation during earlier radiation therapy treatments, decreasing radiation dose to an OAR exposed to an excessive doses of radiation, changing beam placement, and changing EVIRT configurations.
  • generating the second treatment plan can further include acquiring additional MRI images (e.g., 4D MRI images collected during radiation delivery).
  • the MRgRT system 100 can generate the second treatment plan to include additional adjustments to the prescription indicated by the first treatment plan based on the MRI images.
  • the second treatment plan can further include changes to one or more gates (e.g., spatial, temporal) and/or one or more interlock thresholds defined in the first treatment plan for the interlock mechanism.
  • the MRgRT system 100 generates a comparison of the first treatment plan and the second treatment plan (516). Consistent with implementations of the current subject matter, the MRgRT system 100 can generate a side-by-side comparison of a plurality of treatment plans. Multiple treatment plans can be compared with respect to plan parameters including, for example, but not limited to, DVHs, hot and cold spots in dose distribution, and radiation beam parameters (e.g., duration, segment quantity, angle, isocenter radiological depth).
  • plan parameters including, for example, but not limited to, DVHs, hot and cold spots in dose distribution, and radiation beam parameters (e.g., duration, segment quantity, angle, isocenter radiological depth).
  • the MRgRT system 100 can provide alerts when the discrepancy between two treatment plans exceeds one or more thresholds.
  • the MRgRT system 100 can display (e.g., on the display 132 coupled to the user interface 130) dose distributions orthogonally from an MRI image set of the patient.
  • the MRgRT system 100 can indicate differences in dose distribution between multiple treatment plans including by displaying an overlay of the DVHs associated with various treatment plans.
  • One or more operations of the process 500 can be performed in a different order than shown without departing from the scope of the present disclosure. Moreover, one or more operations of the process 500 can be repeated and/or omitted without departing from the scope of the present disclosure.
  • FIG. 6 is a flowchart illustrating a process 600 for treatment planning consistent with implementations of the current subject matter.
  • the process 600 can be performed by the MRgRT system 100 and can implement operation 508 and/or operation 516 of the process 500 described with respect to FIG. 5.
  • the MRgRT system 100 receives at least one MRI image set (602).
  • the MRgRT system 100 can require at least one MRI image set in order to generate a treatment plan.
  • the MRgRT system 100 can receive multimodality MRI image sets, which integrates various different types of medical imaging (e.g., MRI, CT, positron emission tomography (PET), ultrasound).
  • medical imaging e.g., MRI, CT, positron emission tomography (PET), ultrasound.
  • the MRgRT system 100 defines one or more anatomical structure based at least in part on the MRI image set (604).
  • the MRgRT system 100 can automatically determine the contours of one or more of a patient's ROIs and OARs.
  • the MRgRT system 100 performs auto contouring based on anonymous existing data sets and/or earlier data sets from the patient.
  • the MRgRT system 100 can require automatically generated contours to be manually validated.
  • Automatic contours can be a deforming contour or a non-deforming contour.
  • a deforming contour adjusts its shape and/or volume to match the anatomical structure (e.g., ROI, OAR) when placed on an MRI image.
  • a non-deforming contour retains its shape and volume when superimposed upon an MRI image.
  • a non-deforming contour is adapted tracking a region of malignant cells (e.g., clinical targets) that require the same or higher dosage even when the region is receding or has vanished.
  • the MRgRT system 100 can also provide, via the user interface 130, one or more mechanisms for manually segmenting and contouring the patient's anatomy including, for example, but not limited to, outlining tools and voxel painting tools.
  • the MRgRT system 100 can provide a library of anatomical structure names, including custom names added by one or more users, for labeling defined ROIs and/or OARs.
  • an anatomical structure can be defined as an intra-fraction MRI image target volume (ITV).
  • the MRgRT system 100 can generate an ITV as the union of an anatomical structure depicted throughout an MRI image set.
  • the MRgRT system 100 can generate an ITV as the time weighted average of the anatomical structure depicted throughout an MRI image set.
  • Newly created ITVs can be compared to existing ITVs in the orthogonal views on the original MRI image set to create a set of corresponding segmentation contours.
  • multiple sets of contours can be available and/or created for a single anatomical stnicture.
  • the MRgRT system 100 can receive multiple sets of MRI images throughout the course of radiation therapy treatment.
  • the MRgRT system 100 can provide at least some of the contours (e.g., via the user interface 130) in a manner that enables a user to compare the different contours.
  • the MRgRT system 100 can provide at least some of the contours in an overlay with axial, sagital, and/or coronal orthogonal views.
  • the different contours can be shown as voxels in a color wash display.
  • the MRgRT system 100 generates a prescription (606).
  • the prescription can include radiation doses (e.g., dose-volume, dose to points) to be delivered to a patient's ROIs and margins for expansion.
  • the prescription can further include various tolerances that include, for example, but not limited to, dose-volume constraints for OARs. The various tolerances can set limits used for dose prediction and on-table treatment plan re-optimization during the administration of radiation therapy treatment.
  • the prescription can also include one or more spatial and temporal gates to be applied when the gating mechanism is deployed during the administration of radiation therapy treatment.
  • the one or more spatial gates can be determined based on MRI images captured by the MRgRT system 100 (e.g., the MRI system 128) during the delivery of radiation.
  • the prescription can also include additional treatment parameters including, for example, but not limited to, requirements or prohibitions for planar imaging, volumetric imaging, dose prediction, on-table re-optimization, 4D MRI image data acquisition, MRI image target volume (ITV) target generation, planar gating, and delivered dose evaluation.
  • additional treatment parameters including, for example, but not limited to, requirements or prohibitions for planar imaging, volumetric imaging, dose prediction, on-table re-optimization, 4D MRI image data acquisition, MRI image target volume (ITV) target generation, planar gating, and delivered dose evaluation.
  • the radiation doses and tolerances specified in the prescription can be determined based on the cumulative actual radiation doses delivered to the patient (e.g., ROIs and OARs) as determined by the MRgRT system 100 (e.g., the dose reconstruction cluster 150).
  • the actual dose of radiation that was delivered a patient can be determined using MRI images (e.g., 4D MRI images) captured by the MRgRT system 100 (e.g., the MRI system 128) prior to, during, and/or post the administration of radiation therapy.
  • MRI images e.g., 4D MRI images
  • the MRgRT system 100 e.g., the MRI system 1228
  • the MRgRT system 100 generates one or more radiation delivery configuration (608). Consistent with implementations of the current subject matter, the delivery configuration can include, for example, but not limited to, isocenter placement, and beam and/or IMRT or CRT configuration.
  • the MRgRT system 100 can provide a GUI via the user interface 130 to allow a user (e.g., radiotherapist) to manually place one or more isocenters indicating points on an ROI where radiation beams should pass through.
  • a user e.g., radiotherapist
  • the MRgRT system 100 can provide default beam configurations or templates for use with IMRT and/or CRT to assist a user in beam configuration.
  • default beam configurations or templates can be provided for one or more common ROIs including, for example, but not limited to, breast with tangents, breast with tangents and nodal irradiation, head and neck with low neck field, head and neck with separate low neck field, central nervous system, craniospinal, lung, prostate, whole pelvis, right and left hemi pelvis, whole pelvis with or without para-aortics, whole brain, vertebral body, mantle fields, and whole body fields.
  • a user can create and save custom beam configurations as new templates.
  • the user can manually place one or more radiation beams using a beam-eye-view display provided by the MRgRT system 100.
  • the user can place the radiation beams in a plurality of placement modes including, for example, but not limited to, 3 -beam placement and single beam placement.
  • the MRgRT system 100 can provide beam transit time corresponding to the placement of individual radiation beams.
  • one or more of placed radiation beams can be selected for EVIRT.
  • the MRgRT system 100 can provide a GUI for a user to indicate EVIRT configuration parameters including, for example, but not limited to, prescription doses for ROIs, tolerance doses for OARs, and the relative importance of the ROIs and the OARs.
  • the MRgRT system 100 can provide EVIRT templates that include optimized models for administering EVIRT. The templates include predefined values that have been demonstrated to produce ideal results in previous cases. Alternately, a user can also create and save custom EVIRT configurations as EVIRT templates.
  • the MRgRT system 100 can optimize an EVIRT configuration by performing one or more operations including, for example, but not limited to, fluence map optimization (e.g., performed using beamlet dose calculation), leaf sequencing, and segment ordering optimization.
  • the MRgRT system 100 can further optimize the EVIRT configuration by performing Monte Carlo simulations.
  • the MRgRT system 100 performs a "warm start” optimization based on an original EVIRT configuration and an original set of EVIRT configuration parameters.
  • a "warm start” optimization ensures that the optimized EVIRT configuration is similar to the original EVIRT configuration devised for a patient.
  • adjusting one or more EV1RT configuration parameters can steer the optimized IMRT configuration towards a more desirable, albeit divergent, solution.
  • the MRgRT system 100 generates one or more dose predictions based at least in part on the prescription and delivery configuration (610). Consistent with implementations of the current subject matter, the MRgRT system 100 can generate a dose prediction by applying the prescription and the delivery configuration to MRI images captured by the MRgRT system 100 (e.g., the MRI system 128) in order to detect any interplay and/or aliasing effects on dose delivery.
  • the MRgRT system 100 can generate a dose prediction by applying the prescription and the delivery configuration to MRI images captured by the MRgRT system 100 (e.g., the MRI system 128) in order to detect any interplay and/or aliasing effects on dose delivery.
  • the MRgRT system 100 determines whether the dose predication meets one or more clinical obj ectives (611). If the MRgRT system 100 determines that the dose prediction meets the one or more clinical objectives (61 1-Y), the MRgRT system 100 generates a treatment plan that includes the prescription and the delivery configuration (612).
  • Clinical objectives can include, for example, but not limited to, dose-volume constraints on a patient's anatomical structures (e.g., ROIs and OARs), minimum allowed doses for the patient's anatomical structures, maximum doses for the patient's anatomical structures, biologically effective doses or dose volume constraints, tumor control probabilities, and normal tissue (e.g., OAR) complication probabilities.
  • the MRgRT system 100 determines that the dose prediction does not meet the one or more clinical objectives (611-N)
  • the MRgRT system 100 modifies at least one of the prescription and the delivery configuration (614).
  • the MRgRT system 100 generates a dose prediction based on the prescription and the delivery configuration (610) and determines whether the dose prediction meets one or more clinical objectives (611).
  • the MRgRT system 100 can be configured to perform the process 600 a priori (i.e., prior to patient arrival). Alternately or in addition, the MRgRT system 100 can be configured to perform the process 600 "on-table" (e.g., while a patient is present on the patient couch 124).
  • the MRgRT system 100 is capable of performing the process 600 to generate a treatment plan in an efficient and timely manner (e.g., less than 2 minutes) for on-table treatment planning.
  • One or more operations of the process 600 can be performed in a different order than shown without departing from the scope of the present disclosure. Moreover, one or more operations of the process 600 can be repeated and/or omitted without departing from the scope of the present disclosure.
  • FIG. 7 is a flowchart illustrating a process 700 for administering radiation therapy consistent with implementations of the current subject matter.
  • the process 700 can be performed by the MRgRT system 100 and can implement operation 510 of the process 500 described with respect to FIG. 5.
  • the MRgRT system 100 adjusts the position of a patient (702).
  • the MRgRT system 100 can adjust the position of the patient including by adjusting the position of the patient couch 124.
  • the MRgRT system 100 can adjust patient position using a laser system to identify 3 orthogonal "landing points" marked on the skin of the patient.
  • the MRgRT system 100 can store adjustments made during earlier radiation therapy sessions and automatically apply the same adjustments during subsequent radiation therapy sessions.
  • the MRgRT system 100 can assist a user (e.g., a radiotherapist) in performing manual patient adjustments. For instance, the MRgRT system 100 can provide alerts if the lateral and/or vertical limits of couch motion are exceeded or if the patient (or the patient couch 124) is too close to the gantry 120 and/or the radiation therapy head 122.
  • the MRgRT system 100 can also display (e.g., via the display 132 coupled to the user interface 130) the location of the isocenter as well as project the radiation beams placed according to the treatment plan. Additionally, the MRgRT system 100 can verify that the patient is properly positioned by obtaining one or more of orthogonal pilot scans and current primary planning volumes.
  • the MRgRT system 100 simultaneously delivers radiation and performs MRI (704). Consistent with implementations of the current subject matter, the MRgRT system 100 delivers radiation (e.g., via the radiation therapy heads 122) to a patient (e.g., on the patient couch 124) while also capturing MRI images (e.g., using the MRI system 128).
  • the MRgRT system 100 can selectively save MRI images captured during radiation delivery. For example, the MRgRT system 100 can remove MRI images captured when radiation delivery is suspended (e.g., by the gating and/or interlock mechanism) and/or consolidate MRI images that do not depict patient motion in excess of a threshold (e.g., 2mm).
  • a threshold e.g. 2mm
  • the MRgRT system 100 determines whether one or more gates are triggered based on at least a portion of the MRI images captured during the delivery of radiation (705).
  • a gating mechanism can be deployed during radiation delivery.
  • the gating mechanism monitors the positions of one or more anatomical structures (e.g., ROIs and/or OARs) during radiation delivery relative to one or more spatial gates.
  • the position of an anatomical structure can trigger a spatial gate if that anatomical structure shifts outside of the spatial gate (e.g., 3mm).
  • a temporal gate can be triggered if the anatomical structure remains outside of the spatial gate for a length of time in excess of the temporal gate (e.g., 3 seconds).
  • the MRgRT system 100 may determine that one or more gates are not triggered based on at least a portion of the MRI images captured during the delivery of radiation (705-N). For example, the position of the anatomical structure may remain within the one or more spatial gates. Alternately, the position of the anatomical structure may shift outside of the one or more spatial gate but not for a period of time that exceeds a temporal gate. As such, the MRgRT system 100 determines whether patient motion exceeds one or more interlock thresholds based on at least a portion of the MRI images captured during the delivery of radiation (707).
  • an interlock mechanism can be deployed during radiation delivery. The interlock mechanism detects patient motion based on planar MRI images and suspends radiation delivery in response to detecting patient motion that exceeds one or more thresholds.
  • the MRgRT system 100 determines that patient motion exceeds one or more interlock thresholds (707- Y), the MRgRT system 100 suspends the delivery of radiation (708). Alternately, if the MRgRT system 100 determines that patient motion does not exceed one or more interlock thresholds (707-N), the MRgRT system 100 continues to simultaneously deliver radiation and perform medical imaging (704).
  • the MRgRT system 100 determines that one or more gates are triggered based at least a portion of the MRI images captured during the delivery of radiation (705-Y), the MRgRT system 100 suspends the delivery of radiation (708).
  • the position of the anatomical structure may shift outside of the one or more spatial gates.
  • the position of the anatomical structure may shift outside of the one or more spatial gates for a period of time exceeding a temporal gate. Accordingly, the MRgRT system 100 can determine that one or more gates are triggered and suspend radiation delivery.
  • the MRgRT system 100 determines whether one or more conditions causing the suspension of radiation delivery are resolved (709). For example, the MRgRT system 100 can determine whether the anatomical structure has returned to a position inside of the spatial gate. The MRgRT system 100 can also determine whether patient motion in excess of the one or more thresholds has ceased.
  • the MRgRT system 100 determines that the one or more conditions causing the suspension of radiation delivery are resolved (709-Y), the MRgRT system 100 recommences delivery of radiation (710). The MRgRT system 100 continues to simultaneously deliver radiation and perform medical imaging (704). Alternately, if the MRgRT system 100 determines that the one or more conditions triggering the one or more gates are not resolved (709-N), the MRgRT system 100 will continue to suspend the delivery of radiation (706).
  • One or more operations of the process 700 can be performed in a different order than shown without departing from the scope of the present disclosure. Moreover, one or more operations of the process 700 can be repeated and/or omitted without departing from the scope of the present disclosure.
  • FIG. 8 is a flowchart illustrating a process 800 for dose computation consistent with implementations of the current subject matter.
  • the process 800 can be performed by the MRgRT system 100 (e.g., the dose reconstruction cluster 180) and can implement operation 512 of the process 500 described with respect to FIG. 5.
  • the MRgRT system 100 performs deformable image registration on MRI images captured during the delivery of radiation (802). For example, the MRgRT system 100 can perform deformable image registration on a series of MRI images captured by the MRI system 128 prior to, during, or post the administration of radiation therapy. In some implementations of the current subject matter, the MRgRT system 100 can track the absolute deviation of one or more anatomical structures (e.g., ROIs and OARs) from initial locations throughout the delivery of radiation.
  • anatomical structures e.g., ROIs and OARs
  • the MRgRT system 100 identifies one or more anatomical structures for dose computation (804).
  • the actual dose of radiation delivered is affected by patient motion (e.g., shift in patient organ geometry) during the delivery of radiation.
  • the MRgRT system 100 can flag anatomical structures that have moved in excess of a threshold for dose computation whereas anatomical structures that did not demonstrate motion exceeding the threshold are bypassed for dose computation.
  • the MRgRT system 100 can correlate the MRI images captured by the MRgRT system 100 (e.g., the MRI system 128) with radiation beam shapes and fluences through the patient to determine one or more anatomical structures that were not exposed to radiation.
  • the MRgRT system 100 can flag anatomical structures that were exposed to radiation for dose computation while anatomical structures that were not exposed to radiation can be bypassed for dose computation.
  • the MRgRT system 100 generates an initial computation of the actual radiation doses delivered to the one or more anatomical structures identified for dose computation (806). Consistent with implementations of the current subject matter, the MRgRT system 100 can perform a scaled density finite sized pencil beam algorithm to generate the initial computation of the actual radiation doses delivered. Alternately or in addition, the MRgRT system 100 can perform a time dependent Monte Carlo simulation that incorporates control data and MRI images captured by the MRgRT system 100 (e.g., the MRI system 128) during radiation delivery.
  • the actual dose of radiation delivered to the patient can also be affected by interruptions to the delivery of radiation caused by the gating mechanism and/or the interlock mechanism.
  • the gating mechanism and/or the interlock mechanism can cause a series of suspensions in radiation delivery thereby changing the actual dose of radiation delivered to the patient including, for example, but not limited to, shutter dose effects and truncation errors for radiation doses below a safely deliverable threshold.
  • the MRgRT system 100 is configured to generate an initial computation that accounts for the effects of the interruptions to radiation delivery caused by the gating mechanism and/or the interlock mechanism.
  • the MRgRT system 100 can record and account dose variations during radiation delivery and account for such variations when computing the actual dose of radiation delivered to the patient.
  • the MRgRT system 100 computes an uncertainty associated with the initial computation (808).
  • the MRgRT system 100 computes one or more actual radiation doses based at least in part on the initial computation and the uncertainty associated with the initial computation (810).
  • Uncertainty associated with the initial computation of radiation doses can arise due to the random nature of Monte Carlo simulations.
  • uncertainty associated with the initial computation can arise during the course of deformable image registration.
  • deformable image registration provides a probabilistic outcome based on the absolute magnitude of the deformation and the change in connectivity in neighboring voxels.
  • the MRgRT system 100 can compute the actual radiation dose by interpolating a distribution of the initial computation and the uncertainty associated with the initial computation.
  • the MRgRT system 100 generates one or more DVHs reflecting the actual doses delivered (812).
  • the MRgRT system 100 compares the DVHs associated with the actual delivered dose with DVHs associated with a corresponding treatment plan (814).
  • the MRgRT system 100 provides an alert if the comparison between the DVHs associated with the actual delivered doses and the DVHs associated with a corresponding treatment plan indicates a difference in excess of one or more thresholds (814).
  • the MRgRT system 100 can issue a warning (e.g., to a clinician) in the event that a discrepancy between the actual radiation dose delivered to a patient and the radiation dose prescribed in a treatment plan exceeds one or more thresholds including, for example, but not limited to, coverage volume, and hot and cold spots in dose distribution.
  • a warning e.g., to a clinician
  • the MRgRT system 100 can issue a warning (e.g., to a clinician) in the event that a discrepancy between the actual radiation dose delivered to a patient and the radiation dose prescribed in a treatment plan exceeds one or more thresholds including, for example, but not limited to, coverage volume, and hot and cold spots in dose distribution.
  • One or more operations of the process 800 can be performed in a different order than shown without departing from the scope of the present disclosure. Moreover, one or more operations of the process 800 can be repeated and/or omitted without departing from the scope of the present disclosure.
  • FIG. 9 is a flowchart illustrating a process 900 for administering radiation therapy consistent with implementations of the current subject matter.
  • the process 900 can be performed by the MRgRT system 100 and can implement operation 510 of the process 500 described with respect to FIG. 5.
  • the MRgRT system 100 simultaneously delivers radiation and performs MRI (902).
  • the MRgRT system 100 determines whether one or more gates are triggered based on at least a portion of the MRI images captured during the delivery of radiation (903).
  • the MRgRT system 100 can use the MRI images captured during the delivery of radiation to determine whether one or more spatial and/or temporal gates are triggered.
  • the MRgRT system 100 can determine that one or more gates are not triggered based on at least a portion of the MRI images captured during the delivery of radiation (903-N). For example, the position of the anatomical structure may remain within the one or more spatial gates. Alternately, the position of the anatomical structure may shift outside of the one or more spatial gate but not for a period of time that exceeds a temporal gate. As such, the MRgRT system continues to deliver radiation and perform MRI (902).
  • the MRgRT system 100 suspends the delivery of radiation (904).
  • One or more operations of the process 900 can be performed in a different order than shown without departing from the scope of the present disclosure. Moreover, one or more operations of the process 900 can be repeated and/or omitted without departing from the scope of the present disclosure.
  • Implementations of the present disclosure can include, but are not limited to, methods consistent with the descriptions provided above as well as articles that comprise a tangibly embodied machine-readable medium operable to cause one or more machines (e.g., computers, etc.) to result in operations implementing one or more of the described features.
  • machines e.g., computers, etc.
  • computer systems are also described that can include one or more processors and one or more memories coupled to the one or more processors.
  • a memory which can include a computer-readable storage medium, can include, encode, store, or the like one or more programs that cause one or more processors to perform one or more of the operations described herein.
  • Computer implemented methods consistent with one or more implementations of the current subject matter can be implemented by one or more data processors residing in a single computing system or multiple computing systems.
  • Such multiple computing systems can be connected and can exchange data and/or commands or other instructions or the like via one or more connections, including but not limited to a connection over a network (e.g. the Internet, a wireless wide area network, a local area network, a wide area network, a wired network, or the like), via a direct connection between one or more of the multiple computing systems, etc.
  • a network e.g. the Internet, a wireless wide area network, a local area network, a wide area network, a wired network, or the like
  • a direct connection between one or more of the multiple computing systems etc.
  • One or more aspects or features of the subject matter described herein can be realized in digital electronic circuitry, integrated circuitry, specially designed application specific integrated circuits (ASICs), field programmable gate arrays (FPGAs) computer hardware, firmware, software, and/or combinations thereof.
  • ASICs application specific integrated circuits
  • FPGAs field programmable gate arrays
  • These various aspects or features can include implementation in one or more computer programs that are executable and/or interpretable on a programmable system including at least one programmable processor, which can be special or general purpose, coupled to receive data and instructions from, and to transmit data and instructions to, a storage system, at least one input device, and at least one output device.
  • the programmable system or computing system can include clients and servers.
  • a client and server are generally remote from each other and typically interact through a communication network. The relationship of client and server arises by virtue of computer programs running on the respective computers and having a client-server relationship to each other.
  • machine-readable signal refers to any signal used to provide machine instructions and/or data to a programmable processor.
  • the machine- readable medium can store such machine instructions non-transitorily, such as for example as would a non-transient solid-state memory or a magnetic hard drive or any equivalent storage medium.
  • the machine-readable medium can alternatively or additionally store such machine instructions in a transient manner, such as for example as would a processor cache or other random access memory associated with one or more physical processor cores.
  • one or more aspects or features of the subject matter described herein can be implemented on a computer having a display device, such as for example a cathode ray tube (CRT) or a liquid crystal display (LCD) or a light emitting diode (LED) monitor for displaying information to the user and a keyboard and a pointing device, such as for example a mouse or a trackball, by which the user may provide input to the computer.
  • a display device such as for example a cathode ray tube (CRT) or a liquid crystal display (LCD) or a light emitting diode (LED) monitor for displaying information to the user
  • LCD liquid crystal display
  • LED light emitting diode
  • a keyboard and a pointing device such as for example a mouse or a trackball
  • feedback provided to the user can be any form of sensory feedback, such as for example visual feedback, auditory feedback, or tactile feedback; and input from the user can be received in any form, including, but not limited to, acoustic, speech, or tactile input.
  • Other possible input devices include, but are not limited to, touch screens or other touch-sensitive devices such as single or multi -point resistive or capacitive trackpads, voice recognition hardware and software, optical scanners, optical pointers, digital MRI image capture devices and associated interpretation software, and the like.
  • phrases such as "at least one of or "one or more of may occur followed by a conjunctive list of elements or features.
  • the term “and/or” may also occur in a list of two or more elements or features. Unless otherwise implicitly or explicitly contradicted by the context in which it used, such a phrase is intended to mean any of the listed elements or features individually or any of the recited elements or features in combination with any of the other recited elements or features.
  • the phrases “at least one of A and ⁇ ;” “one or more of A and ⁇ ;” and “A and/or B” are each intended to mean "A alone, B alone, or A and B together.”
  • a similar interpretation is also intended for lists including three or more items.
  • phrases “at least one of A, B, and C;” “one or more of A, B, and C;” and “A, B, and/or C” are each intended to mean “A alone, B alone, C alone, A and B together, A and C together, B and C together, or A and B and C together.”
  • Use of the term “based on,” above and in the claims is intended to mean, “based at least in part on,” such that an unrecited feature or element is also permissible.

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Abstract

L'invention concerne la radiothérapie guidée par résonance magnétique (RM) (RTgRM) permettant de maîtriser la distribution de rayonnement sur la base des mouvements du patient indiqués par des images d'imagerie RM (IRM) capturées au cours de la distribution du rayonnement. L'invention concerne également un procédé pour RTgRM comprenant les étapes consistant : à mettre en œuvre simultanément une ou plusieurs têtes de radiothérapie pour distribuer un rayonnement et un système IRM pour effectuer une IRM ; à utiliser un processeur afin de déterminer si une ou plusieurs grilles sont déclenchées sur la base d'au moins une partie des images IRM capturées pendant la distribution du rayonnement ; et après avoir déterminé si une ou plusieurs grilles se sont déclenchées sur la base d'au moins une partie des images IRM capturées pendant la distribution de rayonnement, à suspendre la distribution de rayonnement.
PCT/US2016/017618 2015-02-11 2016-02-11 Planification et commande pour radiothérapie guidée par résonance magnétique WO2016130850A1 (fr)

Priority Applications (10)

Application Number Priority Date Filing Date Title
AU2016219215A AU2016219215B2 (en) 2015-02-11 2016-02-11 Planning and control for magnetic resonance guided radiation therapy
EP16708028.2A EP3256215B1 (fr) 2015-02-11 2016-02-11 Planification et commande pour radiothérapie guidée par résonance magnétique
KR1020177024908A KR20170116070A (ko) 2015-02-11 2016-02-11 자기 공명 유도식 방사선 요법을 위한 계획 및 제어
JP2017542112A JP6893876B2 (ja) 2015-02-11 2016-02-11 磁気共鳴によってガイドされた放射線療法のための計画及び制御
EP23201326.8A EP4325235A3 (fr) 2015-02-11 2016-02-11 Planification et commande pour radiothérapie guidée par résonance magnétique
CN202210997198.XA CN115337557A (zh) 2015-02-11 2016-02-11 用于辐射疗法的系统
CN202011072387.3A CN112043979B (zh) 2015-02-11 2016-02-11 用于辐射治疗的系统
CN201680017015.6A CN107427691B (zh) 2015-02-11 2016-02-11 用于磁共振引导的辐射治疗系统
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