WO2016126215A1 - Formule à base d'acides aminés et son procédé de production - Google Patents

Formule à base d'acides aminés et son procédé de production Download PDF

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Publication number
WO2016126215A1
WO2016126215A1 PCT/TH2015/000007 TH2015000007W WO2016126215A1 WO 2016126215 A1 WO2016126215 A1 WO 2016126215A1 TH 2015000007 W TH2015000007 W TH 2015000007W WO 2016126215 A1 WO2016126215 A1 WO 2016126215A1
Authority
WO
WIPO (PCT)
Prior art keywords
amino acid
based formula
glucose
formula according
rice
Prior art date
Application number
PCT/TH2015/000007
Other languages
English (en)
Inventor
Pipop JIRAPINYO
Original Assignee
Jirapinyo Pipop
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jirapinyo Pipop filed Critical Jirapinyo Pipop
Priority to PCT/TH2015/000007 priority Critical patent/WO2016126215A1/fr
Publication of WO2016126215A1 publication Critical patent/WO2016126215A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula

Definitions

  • Cow milk allergy in infants caused by intolerance to certain proteins present in the cow milk is an important problem which can be commonly found.
  • the number of infants suffering from such allergy has a tendency to constantly increase.
  • the symptoms of cow milk allergy may vary, for example, atopic eczema, respiratory symptoms such as chronic cough or excessive sputum and gastrointestinal symtoms such as vomitting, diarrhea or stomachache, etc.
  • the present invention relates to amino acid-based formula comprising 18 amino acids, rice glucose polymer, sucrose, vegetable oils and optionally, additives and/or water, wherein the rice glucose polymer comprises glucose, maltose, maltotriose and glucose polymer having at least 4 glucose repeat units.
  • the present invention also relates to the production process of amino acid-based formula comprising the steps of: (i) preparing rice glucose polymer by enzymatic hydrolysis of starch and (ii) preparing amino acid-based formula wherein the starch : enzyme : water weight ratio in the preparation of rice glucose polymer by enzymatic hydrolysis of starch is 1 x 10 6 : 1 : 5 x 10 6 .
  • the object of the present invention is to provide amino acid-based formula and the production process thereof to obtain an amino acid-based formula having the least long chain protein possible i.e. having the long hain protein less than 0.05%.
  • Said rice glucose polymer is prepared by enzymatically hydrolysing starch using a particular technique which yields low protein rice glucose polymer which, when formulated with other ingredients such as 18 amino acids, vegetable oils, mineral salts and vitamins, will result in an amino acid-based formula suitable for infant consumption. Accordingly, said amino acid-based can be easily produced in a less costly manner.
  • the present invention relates to amino acid-based formula and the production process thereof.
  • the amino acid-based formula comprises 18 amino acids, rice glucose polymer, sucrose, vegetable oils and optionally, additives and/or water wherein rice glucose polymer comprises glucose, maltose, maltotriose and glucose polymer having at least 4 glucose repeat units.
  • the rice glucose polymer comprises 5-10 % glucose, 5-10 % maltose, 5-10 % maltotriose, 5-10 % glucose polymer having at least 4 glucose repeat units, 5-10 % glucose polymer having at least 5 glucose repeat units, 5-10 % glucose polymer having at least 6 glucose repeat units and 10-20 % glucose polymer having more than 6 glucose repeat units by weight of the total rice glucose polymer.
  • the rice glucose polymer containing protein in an amount of less than 0.05% is obtained by enzymatic hydrolysis of starch, preferably, by hydro lyzing rice starch using amylase enzymes.
  • the rice glucose polymer according to the present invention is present in the total amount ranging from 40-60 wt% based on the total amount of amino acid-based formula.
  • the 18 amino acids according to the present invention comprise histidine preferably in an amount of 2.0-3.0 wt%, isoleucine preferably in an amount of 5.0-7.0 wt%, leucine preferably in an amount of 1.0-1.5 wt%, lysine preferably in an amount of 6.0-9.0 wt%, methionine preferably in an amount of 1.0-2.0 wt%, phenylalanine preferably in an amount of 3.0-5.0 wt%, threonine preferably in an amount of 4.0-5.5 wt%, tryptophan preferably in an amount of 1.5-2.5 wt%, valine preferably in an amount of 5.0-7.5 wt%, arginine preferably in an amount of 3.0-4.5 wt%, alanine preferably in an amount of 3.0-5.0 wt%, aspartic acid preferably in an amount of 8.5-11.0 wt%, cysteine preferably in an amount of 2.0-3.0 wt%, glut
  • the total amount of said sucrose according to the present invention ranges from 10-15 wt% based on the total amount of amino acid-based formula.
  • the vegetable oils according to the present invention are selected from the group consisting of palm oil, soybean oil, sunflower oil, coconut oil, rice bran oil and mixture thereof, preferably palm oil and soybean oil.
  • the vegetable oils according to the present invention are present at the total amount ranging from 14-27 wt% based on the total amount of amino acid-based formula.
  • the additives are selected from the group consisting of calcium lactate, calcium phosphate, magnesium oxide, sodium ferrous citrate, zinc sulfate, potassium iodide, sodium chloride, tripotassium citrate, copper sulfate, manganese sulfate, retinol, biotin, folate, lecithin, carnitine, selenium, taurine, inulin, fructo -oligosaccharides, vitamin C, vitamin D, vitamin E, vitamin K, vitamin Bi, vitamin B 2 , vitamin B 3 , vitamin B5, vitamin B 6 , vitamin B 12 and mixture thereof.
  • Inulin and fructo-oligosaccharides according to the present invention are present at the total amount ranging from 0.50-1.0 wt% based on the total amount of amino acid-based formula.
  • the production process of amino acid-based formula comprises the steps of: (i) preparing the rice glucose polymer by enzymatic hydrolysis of starch and (ii) preparing amino acid-based formula.
  • the preparation of the rice glucose polymer from enzymatic hydrolysis of starch according to the present invention is carried out using the weight ratio of starch : enzyme : water of 1 x 10 6 : 1 : 5 x 10 6 (for example 20 kg : 20 mg : 100 kg).
  • the enzymatic hydrolysis of starch is carried out at a temperature between 80-90 °C, preferably 85°C.
  • the enzyme used is amylase enzyme and the starch is rice starch.
  • the preparation of the amino acid-based formula according to the present invention comprises the steps of:
  • step (c) homogenizing the blend obtained from step (b) to obtain a liquid amino acid-based formula; and (d) optionally drying the liquid amino acid-based formula obtained from step (c) to obtain a powder amino acid-based formula,
  • the preparation of the amino acid-based formula according to the present invention further comprises the steps of adding the additives prior to step (d).
  • amino acid-based formula uses the amount of the aforementioned ingredients comprising 18 amino acids, rice glucose polymer, vegetable oil and optionally, additives as described above.
  • Rice starch was hydro lysed using fungal amylase enzyme in the presence of clean water at the preferred temperature of 85°C for about half an hour. The obtained hydrolysate is then precipitated and the supernatant is used for preparing the amino acid-based formula.
  • the rice glucose polymer obtained from this step may be made into powder prior to the preparation of amino acid-based formula.
  • An exemplary preparation of amino acid-based formula comprises the following steps;
  • the obtained amino acid-based formula will be spray dried so as to render it in powder form. List of additives and the amount used in the preparation of the amino acid-based formula
  • a test of the amino acid-based formula prepared according to the present invention (A) was conducted on infants aged between 0-4 months in comparison with the commercially available arnino acid-based formula (B). 23 of 46 tested infants were found to be intolerant to said commercially available arnino acid-based formula. 7 infants were intolerant to both formulas A and B and 16 from the 23 infants did not show any signs of allergy to formula A.

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pediatric Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

La présente invention concerne une formule à base d'acides aminés comprenant 18 acides aminés, un polymère de glucose de riz, du saccharose, de l'huile végétale et éventuellement, un additif et/ou de l'eau, le polymère de glucose de riz comprenant du glucose, du maltose, du maltotriose et un polymère de glucose présentant au moins 4 unités répétitives de glucose. La présente invention concerne également le procédé de production d'une formule à base d'acides aminés comprenant les étapes consistant à : i) préparer le polymère de glucose de riz par hydrolyse enzymatique de l'amidon et (ii) préparer une formule à base d'acides aminés, le rapport en poids de amidon:enzyme:eau dans la préparation du polymère de glucose de riz par hydrolyse enzymatique de l'amidon étant 1 x 106:1:5 x 106.
PCT/TH2015/000007 2015-02-03 2015-02-03 Formule à base d'acides aminés et son procédé de production WO2016126215A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/TH2015/000007 WO2016126215A1 (fr) 2015-02-03 2015-02-03 Formule à base d'acides aminés et son procédé de production

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/TH2015/000007 WO2016126215A1 (fr) 2015-02-03 2015-02-03 Formule à base d'acides aminés et son procédé de production

Publications (1)

Publication Number Publication Date
WO2016126215A1 true WO2016126215A1 (fr) 2016-08-11

Family

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Family Applications (1)

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PCT/TH2015/000007 WO2016126215A1 (fr) 2015-02-03 2015-02-03 Formule à base d'acides aminés et son procédé de production

Country Status (1)

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WO (1) WO2016126215A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10787476B2 (en) 2013-09-24 2020-09-29 Ajinomoto Co., Inc. Glycoamino acid and use thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07100000A (ja) * 1993-10-01 1995-04-18 Japan Organo Co Ltd 澱粉糖の製造方法
WO2001056406A1 (fr) * 2000-02-04 2001-08-09 Abbott Laboratories Nouvelle formule pediatrique et procedes servant a assurer la nutrition et a ameliorer la tolerance
US20040022926A1 (en) * 2002-06-12 2004-02-05 Ezio Bartocci Rice-based food product and method for making it
WO2007011685A2 (fr) * 2005-07-15 2007-01-25 Creative Research Management Production de produits de substitution du lait a grain complet, produits correspondants et utilisation
WO2009061603A1 (fr) * 2007-11-07 2009-05-14 Mead Johnson Nutrition Company Procédé pour diminuer l'amertume et améliorer le goût de préparations pour nourrisson exemptes de protéine et hydrolysées

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07100000A (ja) * 1993-10-01 1995-04-18 Japan Organo Co Ltd 澱粉糖の製造方法
WO2001056406A1 (fr) * 2000-02-04 2001-08-09 Abbott Laboratories Nouvelle formule pediatrique et procedes servant a assurer la nutrition et a ameliorer la tolerance
US20040022926A1 (en) * 2002-06-12 2004-02-05 Ezio Bartocci Rice-based food product and method for making it
WO2007011685A2 (fr) * 2005-07-15 2007-01-25 Creative Research Management Production de produits de substitution du lait a grain complet, produits correspondants et utilisation
WO2009061603A1 (fr) * 2007-11-07 2009-05-14 Mead Johnson Nutrition Company Procédé pour diminuer l'amertume et améliorer le goût de préparations pour nourrisson exemptes de protéine et hydrolysées

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10787476B2 (en) 2013-09-24 2020-09-29 Ajinomoto Co., Inc. Glycoamino acid and use thereof

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