WO2016107530A1 - 一种随动定焦系统 - Google Patents
一种随动定焦系统 Download PDFInfo
- Publication number
- WO2016107530A1 WO2016107530A1 PCT/CN2015/099344 CN2015099344W WO2016107530A1 WO 2016107530 A1 WO2016107530 A1 WO 2016107530A1 CN 2015099344 W CN2015099344 W CN 2015099344W WO 2016107530 A1 WO2016107530 A1 WO 2016107530A1
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- WO
- WIPO (PCT)
- Prior art keywords
- observation device
- focal length
- fixedly connected
- sample plate
- observation
- Prior art date
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/24—Base structure
- G02B21/248—Base structure objective (or ocular) turrets
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/24—Base structure
- G02B21/26—Stages; Adjusting means therefor
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/0008—Microscopes having a simple construction, e.g. portable microscopes
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/24—Base structure
- G02B21/241—Devices for focusing
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
- G02B21/362—Mechanical details, e.g. mountings for the camera or image sensor, housings
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B25/00—Eyepieces; Magnifying glasses
- G02B25/002—Magnifying glasses
- G02B25/005—Magnifying glasses with means for adjusting the magnifying glass or the object viewed
Definitions
- the present invention relates to the field of microscopic imaging, and more particularly to a follower fixed focus system.
- the microscope magnifies the sample plate through the objective lens. There are multiple samples on the sample plate. After one sample test is completed, the sample plate needs to be moved, and the objective lens is aligned with another sample to enlarge the other sample. Imaging, when testing each sample, it is necessary to ensure that the distance between the sample plate and the objective lens is constant, that is, the imaging working distance of each sample is unchanged.
- the processing technology of the mobile platform itself for installing the sample plate leads to flatness error of the mobile platform. There is also flatness error when the mobile platform and the sample plate are installed, and the sample plate itself also has flatness error, so when the sample plate has a sample A point When moving to another sample B point, there is a problem that the A point and the B point are not in the same plane, causing the imaging distance of the sample A point and the sample B point to change, thereby causing a deviation from the optimal focal length.
- the first method is to improve the accuracy of processing and assembly for the microscope manufacturer, to minimize the flatness error of the sample plate and the moving platform, but the improvement of the processing and assembly process has its limit and is not easy to achieve.
- the second method is that the microscope has a focusing structure.
- the operator can fine-tune the focal length according to experience, but this will result in complicated imaging operation, low efficiency and subjective interference affecting the imaging effect.
- the third method is an intelligent auto-focusing system using infrared ranging, raster ranging, or the like, or Auto-focusing systems such as image recognition auto-focusing systems, but such systems usually include accurate ranging systems, PLC control systems, motor drive systems, image analysis systems, etc., complex systems, high cost, poor stability and adaptability .
- the invention provides a follow-up fixed focus system, which has the advantages of simple structure, low cost and good stability, and solves the problem of focal length deviation caused by the movement of the sample with the moving platform.
- the present invention provides the following technical means.
- a follow-up fixed focus system comprising:
- a carrying platform a sample plate fixed on the carrying platform, a supporting frame vertically connected to the carrying platform, and an observation device slidably disposed on the supporting frame, the observation device including a camera or an eyepiece, an objective lens and a mirror A cylindrical portion, a fixed focal length device having one end fixedly coupled to the observation set and the other end in contact with the sample plate, the fixed focal length device maintaining a vertical distance of the sample plate from the objective lens.
- the system may further include: an elastic structure connected to the support frame and the observation device or connected to the support frame and the fixed focal length device, the elastic structure supporting the observation device and the Fixed focal length device.
- the elastic structure may include:
- the mechanical elastic device may include:
- a limiting member disposed on the support frame, extending through the connecting rod of the limiting member, one end of the connecting rod is fixedly connected with the observation device or the fixed focal length device, and the other end is provided with a protrusion, and is sleeved on the a spring on the connecting rod, the spring card being located between the limiting member and the protrusion.
- the mechanical elastic device may include: when the observation device is inverted:
- a limiting member disposed on the support frame, extending through the connecting rod of the limiting member, one end of the connecting rod is fixedly connected to the observation device or the fixed focal length device, and the other end is fixed, and is sleeved on the connection a spring on the rod, the spring card being located between the limiting member and the viewing device.
- One end of the connecting rod is connected to the observation device, which may be specifically:
- One end of the connecting rod is fixedly connected to the barrel portion of the observation device;
- One end of the connecting rod is connected to the objective lens of the observation device;
- One end of the connecting rod is connected to a camera or eyepiece of the observation device.
- the illuminating device is slidably disposed on the support frame and can be specifically:
- the barrel portion of the observation device is slidably disposed on the support frame;
- An objective lens of the observation device is slidably disposed on the support frame;
- the camera or eyepiece of the observation device is slidably disposed on the support frame.
- the barrel portion may include:
- One end of the connecting base is fixedly connected to the lens barrel, and the other end is slidably disposed on the support frame.
- the fixed focal length device may be a support rod
- One end of the support rod is fixedly connected to the observation device, and the other end is in contact with the sample plate.
- the fixed focal length device may be a support rod and a light transmissive member
- One end of the support rod is fixedly connected to the observation device, and the other end is fixedly connected to the transparent member, and the transparent member is hollow at a position opposite to the objective lens.
- the fixed connection of one end of the support rod to the observing device may be specifically:
- One end of the support rod is fixedly connected to a camera or an eyepiece of the observation device;
- One end of the support rod is fixedly connected to the lens barrel of the observation device; and/or
- One end of the support rod is fixedly connected to the objective lens of the observation device.
- the invention provides a follow-up fixed focus system.
- the system comprises a fixed focal length device.
- the second end of the fixed focal length device is in contact with the sample plate.
- the sample plate is slightly convex, the second end of the fixed focal length device is sampled.
- the protrusion of the plate pushes, causing the observation device to move up with the protrusion. Since the objective lens and the fixed focal length device do not change, the distance between the objective lens and the sample plate can be maintained unchanged, that is, the imaging distance is constant.
- the observation device keeps the second end of the fixed focal length device in contact with the sample plate under its own gravity, and maintains the imaging distance between the objective lens and the sample plate.
- the system can achieve the object of the invention only by adding a fixed focal length device, and the fixed focal length device has the advantages of simple structure, low cost, easy realization, good stability, and can solve the focal length deviation caused by the movement of the sample imaging with the moving platform.
- the problem can solve the focal length deviation caused by the movement of the sample imaging with the moving platform.
- FIG. 1 is a structural diagram of a follow-up fixed focus system according to an embodiment of the present invention.
- FIG. 2 is a structural diagram of still another follow-up fixed focus system according to an embodiment of the present invention.
- FIG. 3 is a structural diagram of still another follow-up fixed focus system according to an embodiment of the present invention.
- FIG. 4 is a structural diagram of still another follow-up fixed focus system according to an embodiment of the present invention.
- FIG. 5 is a structural diagram of still another follow-up fixed focus system according to an embodiment of the present invention.
- FIG. 6 is a structural diagram of still another follow-up fixed focus system according to an embodiment of the present invention.
- the present invention provides a follow-up fixed focus system, comprising:
- a fixed focal length device 300 having a camera or eyepiece 101, an objective lens 103 and a barrel portion 102, one end fixedly connected to the observation setting 100 and the other end in contact with the sample plate 500, the fixed focal length device 300 making the sample plate
- the vertical distance of 500 from the objective lens 103 remains unchanged.
- the present application adds a fixed focal length device 300 between the observation device 100 and the sample plate 500, and the side of the fixed focal length device 300 near the sample plate 500 is The other end is the first end, and when the imaging distance between the objective lens 103 and the sample plate 500 and the length of the fixed focal length device 300 are determined, imaging is reserved between the end of the second end of the fixed focal length device 300 and the objective lens 103. The distance is then fixed to the viewing device 100 at the first end of the fixed focal length device 300.
- the fixed focal length device 300 is less susceptible to deformation due to the rigid structure, and thus the imaging distance between the second end of the fixed focal length device 300 and the objective lens 103 can be maintained.
- the second end of the fixed focal length device 300 is in contact with the sample plate 500.
- the second end of the fixed focal length device 300 is pushed by the projection of the sample plate 500, causing the observation device 100 to also follow the projection. Since the objective lens 103 and the fixed focal length device 300 do not change, it is also possible to maintain the distance between the objective lens 103 and the sample plate 500 unchanged, that is, the imaging distance is constant.
- the observation device 100 causes the second end of the fixed focal length device 300 to always contact the sample plate 500 under its own gravity, maintaining the imaging distance between the objective lens 103 and the sample plate 500 unchanged.
- the end of the fixed focal length device 300 of the present application and the objective lens 103 The distance between the images is the imaging distance.
- the fixed focal length device 300 With the protrusions and depressions of the sample plate 500, the fixed focal length device 300 also moves up and down with the sample plate 500, so that the end of the fixed focal length device 300 is always in contact with the sample plate 500. Further, the distance between the sample plate 500 and the objective lens 103 is always the imaging distance.
- the combination of the observation device 100 and the fixed focal length device 300 is relatively heavy, and in order to protect the sample plate 500 from being crushed by the combination of the observation device 100 and the fixed focal length device 300, as shown in FIG. 2, the present application also adds An elastic structure 600 connected to the support frame 100 or connected to the support frame 200 and the fixed focal length device 300, the elastic structure 600 can support the observation device 100 and the fixed focal length Device 300.
- the elastic structure 600 can support the observation device 100 and the fixed focal length device 300, specifically, an upward pulling force to the observation device 100 and the fixed focal length device 300, and the tension is balanced with the gravity of the observation device 100 and the fixed focal length device 300, so that the compression is made.
- the force of the sample plate 500 is small to protect the integrity of the sample plate 500.
- the elastic structure 600 that can be used includes: a mechanical elastic device, a pneumatic elastic device, and/or a hydraulic elastic device.
- the main function of the elastic structure 600 is to provide an upward pulling force to the observation device 100 and the fixed focal length device 300.
- the mechanical elastic device portion of the elastic structure 600 will be described in detail below with reference to FIG. 2:
- the elastic structure 600 includes: a limiting member 603 disposed on the supporting frame 200 , a connecting rod 604 extending through the limiting member 603 , an end of the connecting rod 604 and the observation device 100 Or the fixed focal length device 300 is fixedly connected, and the other end is provided with a protrusion 601, a spring 602 sleeved on the connecting rod 604, and the spring 602 is stuck between the limiting member 603 and the protrusion 601.
- the spring 602 of the card between the limiting member 603 and the protrusion 601 is a pre-tensioning spring 602.
- the spring 602 has a pre-tightening force.
- the specific process is: the pre-tightening force of the spring 602 acts on the limiting member 603 and the protrusion. Between 601, the limiting member 603 is fixed, so the preloading force is made. There is an upward force on the pair of protrusions 601.
- the protrusions 601 drive the connecting rod 604 to exert an upward force on the connecting rod 604.
- the connecting rod 604 is connected to the observation device 100, so that the observation device 100 also has an upward force.
- the spring 602 preload is less than or equal to the combined gravity of the fixed focal length device 300 and the scope 100, as the preload is too large, causing the fixed focal length device 300 to detach from the sample plate 500 and hang, resulting in a gap between the sample plate 500 and the objective lens 103.
- the distance is greater than the imaging distance.
- the apparatus shown in FIG. 1 can only be used when the observation apparatus 100 is placed upright.
- the observation apparatus 100 and the fixed focal length apparatus 300 move downward due to gravity, resulting in the fixed focal length apparatus 300 being incapable of contacting the sample plate 500.
- the artificial operation inevitably causes uneven force or the purpose of keeping the fixed focal length device 300 in constant contact with the sample plate 500. Therefore, when the observation device 100 is inverted, the elastic structure 600 is added to the original structure, as shown in FIG. It is shown as a structural diagram when the observation apparatus 100 is inverted.
- a fixed focal length device 300 having a camera or eyepiece 101, an objective lens 103 and a barrel portion 102 fixedly connected to the observation setting at one end and in contact with the sample plate 500 at the other end, the fixed focal length device 300 making the sample plate 500
- the vertical distance from the objective lens 103 remains unchanged, and the elastic structure 600 connected to the support frame 200 and the observation device 100 or connected to the support frame 200 and the fixed focal length device 300, the elastic force Structure 600 can support the viewing device 100 and the fixed focal length device 300.
- the device shown in FIG. 3 is similar to FIG. 1, and the elastic mechanism is further added only to FIG. 1, and the elastic mechanism may include: a mechanical elastic device, a pneumatic elastic device, and/or a hydraulic elastic device.
- the mechanical elastic device is described in detail, and specifically includes:
- a limiting member 603 disposed on the support frame 200 extends through the connecting rod 604 of the limiting member 603.
- One end of the connecting rod 604 is fixedly connected to the observation device 100 or the fixed focal length device 300, and the other end is provided.
- the spring 602 of the card between the limiting member 603 and the observing device 100 also pre-tensions the spring 602, the spring 602 is pre-set with a pre-tightening force, and the pre-tightening force of the spring 602 is greater than the combination of the fixed focal length device 300 and the observing device 100,
- the pre-tightening force of the spring 602 acts on the limiting member 603 at one end, and the limiting device 603 is fixed at the other end. Therefore, the pre-tightening force has an upward driving force on the observation device 100, and the fixing test device also follows
- the observation device 100 has an upward urging force together so that the fixed test device is in contact with the sample plate 500.
- FIG. 3 The functions of the other components in FIG. 3 are the same as those in FIG. 1, and are not described herein again.
- the connecting rod 604 is connected to the barrel portion 102.
- the connecting rod 604 is connected to the observation device 100.
- one end of the connecting rod 604 is fixedly connected to the barrel portion 102 of the observation device 100.
- one end of the connecting rod 604 is connected to the objective lens 103 of the observation device 100; one end of the connecting rod 604 is connected to the camera or the eyepiece 101 of the observation device 100. That is, the connecting rod 604 is connected to the observation device 100, because the connecting rod 604 needs to give the observation device 100 a force, so if the two are not connected, the force cannot be transmitted.
- FIG. 1 , FIG. 2 and FIG. 3 show that the barrel portion of the observation device is slidably disposed on the support frame, and of course, the observation device 100 can be slidably disposed on the support frame 200, specifically :
- the barrel portion 102 of the observation device 100 is slidably disposed on the support frame 200; or
- the objective lens 103 of the observation device 100 is slidably disposed on the support frame 200; or
- the camera or the eyepiece 101 of the observation device 100 is slidably disposed on the support frame 200 on.
- the barrel portion 102 includes a connecting base 1021 and a lens barrel 1022;
- One end of the connecting base 1021 is fixedly connected to the lens barrel 1022 , and the other end is slidably disposed on the support frame 200 .
- the fixed focal length device 300 is described in detail below.
- the fixed focal length device 300 can be implemented in various forms. Three types of implementations are described below. It can be understood that other forms of implementation of the fixed focal length device 300 are the protection scope of the present invention.
- the fixed focal length device 300 is a support rod 301.
- One end of the support rod 301 is fixedly connected to the observation device 100, and the other end is in contact with the sample plate 500.
- the support rod 301 is simple in form, but there are also defects in which the support is not reliable and the fixation is unstable. Therefore, the second method is also provided in the present application.
- the second type: the fixed focal length device 300 is a support rod 301 and a light transmitting member 302; one end of the support rod 301 is fixedly connected to the observation device 100, and the other end is fixedly connected to the transparent member 302.
- the light transmitting member 302 is hollow at a position opposite to the objective lens 103.
- the second end of the fixed focal length is not simply a rod support, but is supported by a light transmissive member 302.
- the support member is transparently disposed to facilitate incident light incident through the sample plate 500.
- the position of the light transmitting member 302 corresponding to the objective lens 103 is hollowed out so that the imaging path between the objective lens 103 and the sample plate 500 is not penetrated.
- the third type the first type of the support rod 301 is not stable. Therefore, two support rods 301 are used in the present embodiment, and one support rod 301 is fixed on both sides of the observation device 100, and the length of the support rod 301 is uniform. The positions fixed to the observation device 100 are the same. This way The observation device 100 can be uniformly stressed and relatively stable.
- one end of the support rod 301 is fixedly connected to the observation device 100, specifically:
- One end of the support rod 301 is fixedly connected to the camera or the eyepiece 101 of the observation device 100; or
- One end of the support rod 301 is fixedly connected to the lens barrel of the observation device 100; and/or
- One end of the support rod 301 is fixedly connected to the objective lens 103 of the observation device 100.
- the present invention provides a follower fixed focus system, the system includes a fixed focal length device 300, the second end of the fixed focal length device 300 is in contact with the sample plate 500, and when the sample plate 500 is slightly convex, the fixed focal length device 300 The second end is pushed by the protrusion of the sample plate 500, causing the observation device 100 to also move up with the protrusion. Since the objective lens 103 and the fixed focal length device 300 do not change, the distance between the objective lens 103 and the sample plate 500 can be maintained. Change, that is, the imaging distance does not change. When the sample plate 500 is slightly recessed, the observation device 100 causes the second end of the fixed focal length device 300 to always contact the sample plate 500 under its own gravity, maintaining the imaging distance between the objective lens 103 and the sample plate 500 unchanged.
- the system can achieve the object of the present invention only by adding a fixed focal length device 300, and the fixed focal length device 300 has the advantages of simple structure, low cost, easy realization, and good stability, and can solve the focal length caused by the movement of the sample with the moving platform. The problem of deviation.
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Abstract
Description
Claims (11)
- 一种随动定焦系统,其特征在于,包括:承载平台(400),固定于所述承载平台(400)上的样品板(500),与所述承载平台(400)垂直连接的支撑架(200),可滑动设置于所述支撑架(200)上的观测装置(100),所述观测装置(100)包括相机或目镜(101)、物镜(103)和镜筒部(102),一端与所述观测设置固定相连,另一端与所述样品板(500)接触的固定焦距装置(300),所述固定焦距装置(300)使所述样品板(500)与所述物镜(103)的垂直距离维持不变。
- 如权利要求1所述的系统,其特征在于,还包括:与所述支撑架(200)和所述观测装置(100)相连的、或与所述支撑架(200)和所述固定焦距装置(300)相连的弹力结构(600),所述弹力结构(600)可支撑所述观测装置(100)和所述固定焦距装置(300)。
- 如权利要求2所述的系统,其特征在于,所述弹力结构(600)包括:机械弹力装置、气压弹力装置和/或液压弹力装置。
- 如权利要求3所述的系统,其特征在于,当所述观测装置(100)正置时所述机械弹力装置包括:设置于所述支撑架(200)上的限位部件(603),贯穿所述限位部件(603)的连接杆(604),所述连接杆(604)的一端与所述观测装置(100)或固定焦距装置(300)固定相连,另一端设置有凸起(601),套设于所述连接杆604上的弹簧(602),所述弹簧(602)卡位于所述限位部件(603)与所述凸起(601)之间。
- 如权利要求3所述的系统,其特征在于,当所述观测装置(100)倒置时所述机械弹力装置包括:设置于所述支撑架(200)上的限位部件(603),贯穿所述限位部件 (603)的连接杆(604),所述连接杆(604)的一端与所述观测装置(100)或固定焦距装置(300)固定相连,另一端设置有凸起(601),套设于所述连接杆604上的弹簧(602),所述弹簧(602)卡位于所述限位部件(603)与观测装置(100)之间。
- 如权利要求4或5所述的系统,其特征在于,所述连接杆604一端与所述观测装置(100)相连具体为:所述连接杆604的一端与所述观测装置(100)的镜筒部(102)固定相连;或所述连接杆604的一端与所述观测装置(100)的物镜(103)相连;或所述连接杆604的一端与所述观测装置(100)的相机或目镜(101)相连。
- 如权利要求6所述的系统,其特征在于,所述观测装置(100)可滑动设置于所述支撑架(200)上具体为:所述观测装置(100)的镜筒部(102)可滑动设置于所述支撑架(200)上;或所述观测装置(100)的物镜(103)可滑动设置于所述支撑架(200)上;或所述观测装置(100)的相机或目镜(101)可滑动设置于所述支撑架(200)上。
- 如权利要求7所述的系统,其特征在于,所述镜筒部(102)包括:连接台(1021)和镜筒(1022);所述连接台(1021)一端与所述镜筒固定连接,另一端可滑动设置于所述支撑架(200)上。
- 如权利要求1、2、4或5所述的系统,其特征在于,所述固定焦 距装置(300)为支撑杆(301);所述支撑杆(301)的一端与所述观测装置(100)固定相连,另一端与所述样品板(500)接触。
- 如权利要求1、2、4或5所述的系统,其特征在于,所述固定焦距装置(300)为支撑杆(301)和透光部件(302);所述支撑杆(301)的一端与所述观测装置(100)固定连接,另一端与所述透光部件(302)固定连接,所述透光部件(302)与所述物镜(103)相对的位置上中空。
- 如权利要求9或10所述的系统,其特征在于,所述支撑杆301的一端与所述观测装置(100)固定连接具体为:所述支撑杆(301)的一端与所述观测装置(100)的相机或目镜(101)固定相连;或所述支撑杆(301)的一端与所述观测装置(100)的镜筒固定相连;或所述支撑杆(301)的一端与所述观测装置(100)的物镜(103)固定相连。
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
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US15/313,160 US9804379B2 (en) | 2014-12-29 | 2015-12-29 | Follow-up fixed focus system |
JP2016572823A JP6251422B2 (ja) | 2014-12-29 | 2015-12-29 | フォローアップ型固定焦点システム |
EP15875206.3A EP3133433B1 (en) | 2014-12-29 | 2015-12-29 | Follow-up fixed focus system |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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CN201410848643.1 | 2014-12-29 | ||
CN201410848643.1A CN104459965B (zh) | 2014-12-29 | 2014-12-29 | 一种随动定焦系统 |
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WO2016107530A1 true WO2016107530A1 (zh) | 2016-07-07 |
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PCT/CN2015/099344 WO2016107530A1 (zh) | 2014-12-29 | 2015-12-29 | 一种随动定焦系统 |
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US (1) | US9804379B2 (zh) |
EP (1) | EP3133433B1 (zh) |
JP (1) | JP6251422B2 (zh) |
CN (1) | CN104459965B (zh) |
WO (1) | WO2016107530A1 (zh) |
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CN104459965B (zh) | 2014-12-29 | 2017-12-01 | 上海睿钰生物科技有限公司 | 一种随动定焦系统 |
DE102016108226A1 (de) * | 2016-05-03 | 2017-11-09 | Carl Zeiss Microscopy Gmbh | Mikroskop |
CN106526824A (zh) * | 2017-01-17 | 2017-03-22 | 哈尔滨工业大学 | 自锁式轴向显微对焦装置 |
CN109239899A (zh) * | 2017-03-09 | 2019-01-18 | 王国涛 | 一种便于拆卸的生物观察用显微镜 |
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CN104459965B (zh) | 2017-12-01 |
JP2017524971A (ja) | 2017-08-31 |
US9804379B2 (en) | 2017-10-31 |
EP3133433B1 (en) | 2019-10-02 |
US20170192218A1 (en) | 2017-07-06 |
EP3133433A1 (en) | 2017-02-22 |
CN104459965A (zh) | 2015-03-25 |
JP6251422B2 (ja) | 2017-12-20 |
EP3133433A4 (en) | 2017-09-20 |
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