WO2016086444A1

WO2016086444A1 - Coagulometer and network hospital medical system for preventing thrombosis

Info

Publication number: WO2016086444A1
Application number: PCT/CN2014/093627
Authority: WO
Inventors: 张贯京; 赫斯奥夫·哈瑞; 穆桑特·卢卡; 马丁阿尔贝托·贝尼托; 普拉纽克·克里斯基捏; 古列莎·艾琳娜; 刘遥峰; 张俊然
Original assignee: 深圳市共创百业科技开发有限公司; 深圳市易特科信息技术有限公司
Priority date: 2014-12-06
Filing date: 2014-12-11
Publication date: 2016-06-09
Also published as: CN104545943B; CN104545943A

Abstract

A coagulometer and network hospital medical system for preventing thrombosis, the coagulometer comprising a blood collector (1) and a detector (2); the blood collector (1) is a semi-enclosed tubular member for obtaining and containing blood, a magnetic metal bead (101) being disposed within the semi-enclosed tubular member; after the blood is obtained, the magnetic metal bead (101) is immersed in the blood; the detector (2) comprises a main controller (10), at least two magnetic field circuits (20) and an induction circuit (30), the main controller (10) being electrically connected to the at least two magnetic field circuits (20) and the induction circuit (30) respectively, and controlling the at least two magnetic field circuits (20) to alternately and successively generate a magnetic field, and to concurrently receive an output signal of the induction circuit (30); the detector (2) determines blood coagulation via the at least two magnetic field circuits (20) driving the magnetic metal bead (101) to reciprocate in the tubular member, and via the induction circuit (30) detecting a movement of the magnetic metal bead (101). The coagulometer has a simple structure and accurate measurement, and the medical system enables a patient to obtain professional advice from more doctors.

Description

Blood coagulation instrument and medical system for preventing thrombosis in network hospitals

[Technical Field]

The invention relates to the technical field of medical equipment, in particular to a blood coagulation instrument and a medical system for preventing thrombosis in a network hospital.

【Background technique】

Portable blood coagulation devices bring a lot of convenience to people with thrombosis, and patients can determine the probability of thrombosis by measuring blood data by themselves. The main function of the blood coagulation instrument is to calculate the clotting time of the blood. Blood coagulation instruments mostly use optical methods and magnetic beads to determine blood clotting time. The traditional blood coagulation instrument blindly pursues precision and the internal structure is complicated, which makes it expensive.

On the other hand, although the blood coagulation instrument can measure the blood coagulation time, the patients generally do not have professional medical knowledge. Even if the blood coagulation data is measured, if the analysis and guidance of the doctor is lacking, it is of little significance to the patient.

[Summary of the Invention]

Based on this, it is necessary to provide a blood coagulation instrument with a simple structure.

In addition, a medical system for preventing thrombosis in a network hospital is also provided.

a blood coagulation instrument comprising a blood collection device and a detector;

The blood collection device is a semi-closed tubular member provided with a magnetically conductive metal bead for collecting and containing blood; after collecting blood, the magnetically conductive metal bead is immersed in the blood;

The detector includes a main controller, at least two magnetic field circuits, and a sensing circuit, the main controller is electrically connected to the at least two magnetic field circuits and the sensing circuit, respectively, and the main controller controls the at least two paths The magnetic field circuit alternately generates a magnetic field in sequence, and simultaneously receives an output signal of the sensing circuit;

The detector drives the magnetic conductive metal beads to reciprocate in the tubular member by at least two magnetic fields, and detects the movement of the magnetic conductive metal beads through an induction circuit to determine a blood coagulation condition;

The detector further includes at least two U-shaped brackets arranged in parallel, the magnetic field circuit is in one-to-one correspondence with the U-shaped bracket, and the inductance coil of the magnetic field circuit is attached to the U-shaped bracket to form a U-shape.

In one embodiment, the at least two magnetic field circuits comprise a first magnetic field circuit and a second magnetic field circuit, the inductive coil of the inductive circuit being coupled to an inductive coil of the first magnetic field circuit or the second magnetic field circuit.

In one of the embodiments, the main controller is an 8051 microcontroller.

In one embodiment, the first magnetic field circuit includes a first resistor, a first transistor, a first diode, and a first inductive coil;

The first diode is connected in parallel with the first inductive coil;

a cathode of the first diode is connected to a positive pole of the power supply, and a cathode of the first diode is connected to a collector of the first transistor;

The base of the first transistor is connected to one of the PWM signal outputs of the 8051 microcontroller through the first resistor, and the emitter of the first transistor is grounded.

In one embodiment, the second magnetic field circuit includes a second resistor, a second transistor, a second diode, and a second inductor;

The second diode is connected in parallel with the second inductive coil;

a cathode of the second diode is connected to a positive pole of the power supply, and a cathode of the second diode is connected to a collector of the second transistor;

The base of the second transistor is connected to the other PWM signal output end of the 8051 single chip through the first resistor, and the emitter of the second transistor is grounded.

In one embodiment, the sensing circuit includes a third resistor, a fourth resistor, a fifth resistor, a sixth resistor, a first capacitor, a second capacitor, a third transistor, and a third inductor;

The collector of the third transistor is connected to one of the signal input terminals of the 8051 single chip through a third resistor; the collector of the third transistor is also connected to the positive pole of the power supply through the fourth resistor;

The base of the third transistor is connected to one of the control signal output terminals of the 8051 single chip through a fifth resistor; the base of the third transistor is also connected to the positive pole of the power supply through the sixth resistor; The base of the third transistor is also grounded through the first capacitor and the second capacitor connected in series;

One end of the third inductive coil is connected to a common end of the first capacitor and the second capacitor, and the other end is grounded;

The emitter of the third transistor is connected to the tap of the third inductor.

A medical system for preventing thrombosis in a network hospital, comprising the above blood coagulation apparatus, further comprising a communication device and a data center, the communication device collecting data of the blood coagulation instrument and transmitting to the data center, the data center pair The received data is processed and managed.

In one of the embodiments, the data center includes a feedback device that communicates with the communication device to transmit a processing result of the data center to the communication device.

In one embodiment, the blood coagulation apparatus includes a wireless communication module that wirelessly collects data of the blood coagulation apparatus.

In one embodiment, the wireless communication module is a Bluetooth module or a wifi module, and the communication device is a smart terminal.

The above blood coagulation instrument uses a magnetic field to detect the displacement of the metal beads to detect blood coagulation, and has a simple structure and high detection precision.

The above-mentioned network hospital is used for the prevention of blood clots, so that patients can not only obtain their own blood coagulation data through the blood coagulation instrument, but also interact with the data center to obtain more professional guidance from doctors.

[Description of the Drawings]

1 is a schematic structural view of a blood coagulation apparatus according to an embodiment

2 is a diagram of a detector module of an embodiment;

3 is a flow chart of a method for detecting a detector of an embodiment;

4 is a diagram of a detector module of another embodiment;

Figure 5 is a circuit schematic diagram of the detector of the embodiment shown in Figure 4;

6 is a flow chart of a method for measuring blood clotting time according to another embodiment;

7 is a block diagram of a medical system for preventing thrombosis in a network hospital according to an embodiment.

【detailed description】

As shown in Fig. 1, it is a schematic structural view of a blood coagulation apparatus of an embodiment. The blood coagulation apparatus includes a blood collection device 1 and a detector 2. The blood collection device 1 is a semi-closed tubular member having a magnetically conductive metal bead 101 therein for collecting and containing blood; after collecting blood, the magnetic conductive metal bead 101 is immersed in the blood.

As shown in FIG. 2, the detector 2 includes a main controller 10, at least two magnetic field circuits 20, and an inductive circuit 30. The main controller 10 is electrically connected to the at least two magnetic field circuits 20 and the induction circuit 30, respectively. Referring to FIG. 1, the detector 2 further includes at least two U-shaped brackets 80 arranged in parallel, the magnetic field circuit 20 is in one-to-one correspondence with the U-shaped bracket 80, and the inductance coil of the magnetic field circuit 20 is attached to the U-shaped bracket. 80 forms a U shape. The sensing circuit 30 is disposed on the outer U-shaped bracket 80.

The magnetic field circuit 20 can generate a magnetic field to drive the magnetic metal bead 101 to move. When the magnetic conductive metal bead 101 is at different positions, the signal outputted by the sensing circuit 30 is different.

As shown in FIG. 3, the method of measuring blood coagulation time includes the following steps.

Step S110: Initialize at least two position values corresponding to the at least two magnetic field circuits. For each magnetic field circuit 20. The main controller 10 activates the magnetic field circuit 20 to generate a magnetic field. This magnetic field will drive the magnetically conductive metal bead 101 into the magnetic field generated by the currently activated magnetic field circuit 20 and fix the position.

The main controller 10 activates the sensing circuit 30 to measure an output signal of the sensing circuit 30 when the magnetically conductive metal bead 101 is located in a magnetic field generated by the currently activated magnetic field circuit 20 as the currently activated magnetic field circuit 20 Corresponding position value.

It should be noted that when the position value is initialized, only one magnetic field circuit 20 operates, that is, when the currently activated magnetic field circuit 20 operates, the other magnetic field circuits 20 are turned off.

Step S120: sequentially starting the at least two magnetic field circuits alternately to generate at least two alternating magnetic field driving metal beads for reciprocating motion; and simultaneously starting timing. For example, the magnetic field circuit 20 is sequentially activated from left to right in FIG. 1, and after the start of the rightmost magnetic field circuit 20 is completed, the magnetic field circuit 20 is sequentially activated from right to left.

Step S130: When the time interval of the metal bead passing the same distance is greater than a preset value, the timing ends, and the time is obtained. When the magnetically conductive metal bead 101 passes through the different magnetic field circuits 20, the sensing circuit 30 can detect the corresponding position value. When the blood coagulation time is detected, since the blood gradually solidifies, the resistance to the magnetic metal beads 101 gradually increases, and the time during which the magnetic metal beads 101 pass the same distance becomes longer and longer. When the time is greater than the preset value, the blood has solidified.

For the sake of simplicity, a detector including two magnetic field circuits will now be described as an example.

As shown in Figure 4, a block diagram of a detector of an embodiment. The detector includes a main controller 100, a first magnetic field circuit 200, a second magnetic field circuit 300, a sensing circuit 400, a reset circuit 500, an oscillating circuit 600, and a display circuit 700. The main controller 100 is electrically connected to the first magnetic field circuit 200, the second magnetic field circuit 300, and the sensing circuit 400, respectively, and the main controller 100 outputs a pulse width modulation signal to control the first magnetic field circuit 200 and the second magnetic field. The circuit 300 alternately generates a magnetic field while receiving an output signal of the sensing circuit 400.

As shown in FIG. 5, the main controller 100 is an 8051 single chip microcomputer. The first magnetic field circuit 200 includes a first resistor R3, a first transistor VT1, a first diode D2, and a first inductor L1; the first diode D2 is connected in parallel with the first inductor L1; a cathode of the first diode D2 is connected to a positive pole of the power supply VCC, a cathode of the first diode D2 is connected to a collector of the first transistor VT1; and a cathode of the first transistor VT1 is The base is connected to one of the PWM signal output terminals (AD3/P0.3) of the 8051 microcontroller through the first resistor R3, and the emitter of the first transistor VT1 is grounded.

The second magnetic field circuit 300 includes a second resistor R4, a second transistor VT2, a second diode D3, and a second inductor L2; the second diode D3 is connected in parallel with the second inductor L2; The cathode of the second diode D3 is connected to the positive pole of the power supply VCC, the anode of the second diode D3 is connected to the collector of the second transistor VT2, and the cathode of the second transistor VT2 is The base is connected to the other PWM signal output terminal (AD2/P0.2) of the 8051 microcontroller through the first resistor R3, and the emitter of the second transistor VT2 is grounded.

The sensing circuit 400 includes a third resistor R5, a fourth resistor R8, a fifth resistor R6, a sixth resistor R7, a first capacitor C4, a second capacitor C5, a third transistor VT3, and a third inductor coil; The collector of the third transistor VT3 is connected to one of the signal input terminals (AD0/P0.0) of the 8051 microcontroller through a third resistor R5; the collector of the third transistor VT3 also passes through the fourth resistor R8 is connected to the positive power supply VCC; the base of the third transistor VT3 is connected to one of the control signal output terminals (AD1/P0.1) of the 8051 single chip through a fifth resistor R6; The base of the pole tube VT3 is also connected to the positive pole of the power supply VCC through the sixth resistor R7; the base of the third transistor VT3 is also grounded through the first capacitor C4 and the second capacitor C5 connected in series; the third inductor One end of the coil is connected to the common end of the first capacitor C4 and the second capacitor C5, and the other end is grounded; the emitter of the third transistor VT3 is connected to the tap of the third inductor coil.

The reset circuit 500 includes a third capacitor C1, a first switch S1, and a seventh resistor R2. The third capacitor C1 and the first switch S1 are connected in parallel with the seventh resistor R2 in series with the power supply VCC positive and ground. One end of the seventh resistor R2 that is not grounded is connected to the reset terminal RST of the 8051 one-chip computer.

The oscillating circuit 600 includes a crystal oscillator X1, a fourth capacitor C3, and a fifth capacitor C2. The fourth capacitor C3 is connected between the first clock terminal XTAL1 of the 8051 microcontroller and ground; the fifth capacitor C2 is connected to The second clock terminal XTAL2 of the 8051 microcontroller is connected to the ground; the crystal oscillator X1 is connected between the first clock terminal XTAL1 and the second clock terminal XTAL2.

In one of the embodiments, the position value includes a first position value and a second position value. Then the above step S130 includes:

The main controller 100 activates the first magnetic field circuit 200 and determines whether the output signal of the sensing circuit 300 reaches the first position value within a preset time, and if so, the main controller 100 activates the second magnetic field The circuit 300 and the first magnetic field circuit 200 is turned off; Otherwise, it is determined that the time interval at which the metal beads reach the same position twice is greater than a preset value.

After the main controller 100 activates the second magnetic field circuit 300, it is determined whether the output signal of the sensing circuit 400 reaches the second position value within a preset time, and if so, the main controller 100 starts the first magnetic field. The circuit 200 closes the second magnetic field circuit 300; otherwise, it is determined that the time interval at which the metal beads reach the same position twice is greater than a preset value.

When the time interval in which the metal bead passes the same distance is greater than a preset value, the timing is output.

In another embodiment, the at least two position values further include a third position value and a fourth position value between the first position value and the second position value, and the position values are all The sensing circuit 400 outputs a period of the signal.

Third position value = (second position value - first position value) / 4 + first position value;

The fourth position value = (first position value - second position value) / 4 + second position value.

Referring to FIG. 6, the above step S130 includes:

Step A: The main controller 100 activates the first magnetic field circuit 200 and initializes the count value to zero. For example, the count variable is used to save the count value.

Step B: After waiting for the preset sub-period, the main controller 100 measures the period of the output signal of the sensing circuit 400. The preset value is 1 second, and the preset sub-period can be 100 milliseconds (ms).

Step C: Increase the count value by one and increase the count time by the preset sub-period. Count=count+1, the timing is increased by 100 milliseconds.

Step D: determining whether the count value exceeds the pre-designed value, and if so, outputting the timing time, otherwise it is further determined whether the period of the output signal of the sensing circuit 400 is smaller than the third position value. The pre-designed value corresponds to the preset value. For example, if the preset value is 1 second and the preset sub-time period is 100 milliseconds, the preset count value is 10. That is, it is judged whether count is greater than 10.

If the period of the output signal of the sensing circuit 400 is less than the third position value, the above steps B~D are repeated; otherwise, step E is performed. The third position value reflects the position of the metal bead adjacent to the first magnetic field circuit 200. If the period of the output signal of the sensing circuit 400 is less than the value, it indicates that the metal bead continues to approach the first magnetic field circuit 200.

Step E: The main controller 100 activates the second magnetic field circuit 300 to initialize the count value to zero. After the above steps B~D, if the period of the output signal of the sensing circuit 400 is greater than the third position value, the metal bead approaches the second magnetic field circuit. In this case, reset the count value to 0.

Step F: After waiting for the preset sub-period, the main controller 100 measures the period of the output signal of the sensing circuit 400. The preset value is 1 second, and the preset sub-period can be 100 milliseconds (ms).

Step G: Increase the count value by one and increase the count time by the preset sub-period. Count=count+1, the timing is increased by 100 milliseconds. At this point, the timing has increased by 200 milliseconds.

Step H: determining whether the count value exceeds the pre-designed value, and if so, outputting the timing time, otherwise it is further determined whether the period of the output signal of the sensing circuit 400 is smaller than the fourth position value. The pre-designed value corresponds to the preset value. For example, if the preset value is 1 second and the preset sub-time period is 100 milliseconds, the preset count value is 10. That is, it is judged whether count is greater than 10.

If the period of the output signal of the sensing circuit 400 is less than the fourth position value, the above steps F~H are repeated; otherwise, step A is performed. The fourth position value reflects the position of the metal bead adjacent to the second magnetic field circuit 300. If the period of the output signal of the sensing circuit 400 is less than the value, it indicates that the metal bead continues to approach the second magnetic field circuit 300.

When the blood gradually solidifies, the above process will eventually end at step D or step H, and the timing time is output.

Based on the blood coagulation apparatus described above, a medical system for preventing thrombosis in a network hospital of an embodiment is provided.

As shown in FIG. 7, the medical system for preventing thrombus in the network hospital includes the blood coagulation apparatus, the communication device 50, and the data center 60 of the above embodiment. Communication device 50 collects data from the coagulometer and sends it to data center 60, which processes and manages the received data.

The blood coagulation apparatus includes a wireless communication module 40 that wirelessly collects data of the blood coagulation apparatus. The wireless communication module 40 can be a Bluetooth module or a wifi module, and the communication device 50 is a smart terminal, such as a smart phone, a tablet or a notebook. The data of the blood coagulation instrument may include blood coagulation time of the current test, test time, relevant information of the test person, and the like.

The data center 60 processes and manages the blood coagulation data, can form historical data of the patient, and generates related reports, conclusions, charts, and the like according to the historical data, which helps to track the physical condition of the patient. The data center 60 can also assign patient data to the physician user, who can obtain professional advice and guidance based on the patient's condition after obtaining the authority to view the patient data.

Data center 60 also includes feedback device 610. The feedback device 610 communicates with the communication device 50 and transmits the processing result of the data center to the communication device 50. The physician user can also feed back their suggestions and guidance information to the patient via feedback device 610.

The technical features of the above-described embodiments may be arbitrarily combined. For the sake of brevity of description, all possible combinations of the technical features in the above embodiments are not described. However, as long as there is no contradiction between the combinations of these technical features, All should be considered as the scope of this manual.

The above-described embodiments are merely illustrative of several embodiments of the present invention, and the description thereof is more specific and detailed, but is not to be construed as limiting the scope of the invention. It should be noted that a number of variations and modifications may be made by those skilled in the art without departing from the spirit and scope of the invention. Therefore, the scope of the invention should be determined by the appended claims.

Claims

A blood coagulation instrument, comprising: a blood collection device and a detector;

The blood collection device is a semi-closed tubular member provided with a magnetically conductive metal bead for collecting and containing blood; after collecting blood, the magnetically conductive metal bead is immersed in the blood;

The detector includes a main controller, at least two magnetic field circuits, and a sensing circuit, the main controller is electrically connected to the at least two magnetic field circuits and the sensing circuit, respectively, and the main controller controls the at least two paths The magnetic field circuit alternately generates a magnetic field in sequence, and simultaneously receives an output signal of the sensing circuit;

The detector drives the magnetically conductive metal beads to reciprocate in the tubular member by at least two magnetic fields, and detects the movement of the magnetically conductive metal beads through an inductive circuit to determine a blood coagulation condition.
The blood coagulation apparatus according to claim 1, wherein the detector further comprises at least two U-shaped brackets arranged side by side, the magnetic field circuit corresponding to the U-shaped bracket, the inductance of the magnetic field circuit The coil is attached to the U-shaped bracket to form a U shape.
The blood coagulation apparatus according to claim 2, wherein said at least two magnetic field circuits comprise a first magnetic field circuit and a second magnetic field circuit, said induction coil of said induction circuit and said first magnetic field circuit or second The inductance coil of the magnetic field circuit is coupled; the main controller is an 8051 single chip microcomputer.
The blood coagulation apparatus according to claim 3, wherein the first magnetic field circuit comprises a first resistor, a first transistor, a first diode, and a first inductive coil;

The first diode is connected in parallel with the first inductive coil;

a cathode of the first diode is connected to a positive pole of the power supply, and a cathode of the first diode is connected to a collector of the first transistor;

The base of the first transistor is connected to one of the PWM signal outputs of the 8051 microcontroller through the first resistor, and the emitter of the first transistor is grounded.
The blood coagulation apparatus according to claim 3, wherein the second magnetic field circuit comprises a second resistor, a second transistor, a second diode, and a second inductor;

The second diode is connected in parallel with the second inductive coil;

a cathode of the second diode is connected to a positive pole of the power supply, and a cathode of the second diode is connected to a collector of the second transistor;

The base of the second transistor is connected to the other PWM signal output end of the 8051 single chip through the first resistor, and the emitter of the second transistor is grounded.
The blood coagulation apparatus according to claim 3, wherein the sensing circuit comprises a third resistor, a fourth resistor, a fifth resistor, a sixth resistor, a first capacitor, a second capacitor, a third transistor, and Third inductive coil;

The collector of the third transistor is connected to one of the signal input terminals of the 8051 single chip through a third resistor; the collector of the third transistor is also connected to the positive pole of the power supply through the fourth resistor;

The base of the third transistor is connected to one of the control signal output terminals of the 8051 single chip through a fifth resistor; the base of the third transistor is also connected to the positive pole of the power supply through the sixth resistor; The base of the third transistor is also grounded through the first capacitor and the second capacitor connected in series;

One end of the third inductive coil is connected to a common end of the first capacitor and the second capacitor, and the other end is grounded;

The emitter of the third transistor is connected to the tap of the third inductor.
A medical system for preventing thrombosis in a network hospital, comprising the blood coagulation apparatus according to any one of claims 1 to 6, further comprising a communication device and a data center, wherein the communication device collects data of the blood coagulation instrument and sends it to the office The data center, the data center processes and manages the received data.
The medical system for preventing thrombosis in a network hospital according to claim 7, wherein the data center includes a feedback device, and the feedback device communicates with the communication device to transmit a processing result of the data center to the communication device.
The medical system for preventing thrombosis in a network hospital according to claim 7, wherein the blood coagulation apparatus comprises a wireless communication module, and the communication device collects data of the blood coagulation apparatus by wireless means.
The medical system for preventing thrombosis in a network hospital according to claim 9, wherein the wireless communication module is a Bluetooth module or a wifi module, and the communication device is an intelligent terminal.