WO2016086444A1 - Système médical d'hôpital en réseau et de coagulomètre pour prévenir une thrombose - Google Patents

Système médical d'hôpital en réseau et de coagulomètre pour prévenir une thrombose Download PDF

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Publication number
WO2016086444A1
WO2016086444A1 PCT/CN2014/093627 CN2014093627W WO2016086444A1 WO 2016086444 A1 WO2016086444 A1 WO 2016086444A1 CN 2014093627 W CN2014093627 W CN 2014093627W WO 2016086444 A1 WO2016086444 A1 WO 2016086444A1
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WO
WIPO (PCT)
Prior art keywords
magnetic field
transistor
resistor
blood coagulation
blood
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PCT/CN2014/093627
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English (en)
Chinese (zh)
Inventor
张贯京
赫斯奥夫·哈瑞
穆桑特·卢卡
马丁阿尔贝托·贝尼托
普拉纽克·克里斯基捏
古列莎·艾琳娜
刘遥峰
张俊然
Original Assignee
深圳市共创百业科技开发有限公司
深圳市易特科信息技术有限公司
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Application filed by 深圳市共创百业科技开发有限公司, 深圳市易特科信息技术有限公司 filed Critical 深圳市共创百业科技开发有限公司
Publication of WO2016086444A1 publication Critical patent/WO2016086444A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150343—Collection vessels for collecting blood samples from the skin surface, e.g. test tubes, cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/4905—Determining clotting time of blood
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06Q—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES; SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES, NOT OTHERWISE PROVIDED FOR
    • G06Q50/00—Information and communication technology [ICT] specially adapted for implementation of business processes of specific business sectors, e.g. utilities or tourism
    • G06Q50/10—Services
    • G06Q50/22—Social work or social welfare, e.g. community support activities or counselling services

Definitions

  • the invention relates to the technical field of medical equipment, in particular to a blood coagulation instrument and a medical system for preventing thrombosis in a network hospital.
  • Portable blood coagulation devices bring a lot of convenience to people with thrombosis, and patients can determine the probability of thrombosis by measuring blood data by themselves.
  • the main function of the blood coagulation instrument is to calculate the clotting time of the blood.
  • Blood coagulation instruments mostly use optical methods and magnetic beads to determine blood clotting time.
  • the traditional blood coagulation instrument blindly pursues precision and the internal structure is complicated, which makes it expensive.
  • the blood coagulation instrument can measure the blood coagulation time, the patients generally do not have professional medical knowledge. Even if the blood coagulation data is measured, if the analysis and guidance of the doctor is lacking, it is of little significance to the patient.
  • a medical system for preventing thrombosis in a network hospital is also provided.
  • a blood coagulation instrument comprising a blood collection device and a detector
  • the blood collection device is a semi-closed tubular member provided with a magnetically conductive metal bead for collecting and containing blood; after collecting blood, the magnetically conductive metal bead is immersed in the blood;
  • the detector includes a main controller, at least two magnetic field circuits, and a sensing circuit, the main controller is electrically connected to the at least two magnetic field circuits and the sensing circuit, respectively, and the main controller controls the at least two paths
  • the magnetic field circuit alternately generates a magnetic field in sequence, and simultaneously receives an output signal of the sensing circuit;
  • the detector drives the magnetic conductive metal beads to reciprocate in the tubular member by at least two magnetic fields, and detects the movement of the magnetic conductive metal beads through an induction circuit to determine a blood coagulation condition;
  • the detector further includes at least two U-shaped brackets arranged in parallel, the magnetic field circuit is in one-to-one correspondence with the U-shaped bracket, and the inductance coil of the magnetic field circuit is attached to the U-shaped bracket to form a U-shape.
  • the at least two magnetic field circuits comprise a first magnetic field circuit and a second magnetic field circuit, the inductive coil of the inductive circuit being coupled to an inductive coil of the first magnetic field circuit or the second magnetic field circuit.
  • the main controller is an 8051 microcontroller.
  • the first magnetic field circuit includes a first resistor, a first transistor, a first diode, and a first inductive coil;
  • the first diode is connected in parallel with the first inductive coil
  • a cathode of the first diode is connected to a positive pole of the power supply, and a cathode of the first diode is connected to a collector of the first transistor;
  • the base of the first transistor is connected to one of the PWM signal outputs of the 8051 microcontroller through the first resistor, and the emitter of the first transistor is grounded.
  • the second magnetic field circuit includes a second resistor, a second transistor, a second diode, and a second inductor;
  • the second diode is connected in parallel with the second inductive coil
  • a cathode of the second diode is connected to a positive pole of the power supply, and a cathode of the second diode is connected to a collector of the second transistor;
  • the base of the second transistor is connected to the other PWM signal output end of the 8051 single chip through the first resistor, and the emitter of the second transistor is grounded.
  • the sensing circuit includes a third resistor, a fourth resistor, a fifth resistor, a sixth resistor, a first capacitor, a second capacitor, a third transistor, and a third inductor;
  • the collector of the third transistor is connected to one of the signal input terminals of the 8051 single chip through a third resistor; the collector of the third transistor is also connected to the positive pole of the power supply through the fourth resistor;
  • the base of the third transistor is connected to one of the control signal output terminals of the 8051 single chip through a fifth resistor; the base of the third transistor is also connected to the positive pole of the power supply through the sixth resistor; The base of the third transistor is also grounded through the first capacitor and the second capacitor connected in series;
  • One end of the third inductive coil is connected to a common end of the first capacitor and the second capacitor, and the other end is grounded;
  • the emitter of the third transistor is connected to the tap of the third inductor.
  • a medical system for preventing thrombosis in a network hospital comprising the above blood coagulation apparatus, further comprising a communication device and a data center, the communication device collecting data of the blood coagulation instrument and transmitting to the data center, the data center pair The received data is processed and managed.
  • the data center includes a feedback device that communicates with the communication device to transmit a processing result of the data center to the communication device.
  • the blood coagulation apparatus includes a wireless communication module that wirelessly collects data of the blood coagulation apparatus.
  • the wireless communication module is a Bluetooth module or a wifi module
  • the communication device is a smart terminal.
  • the above blood coagulation instrument uses a magnetic field to detect the displacement of the metal beads to detect blood coagulation, and has a simple structure and high detection precision.
  • the above-mentioned network hospital is used for the prevention of blood clots, so that patients can not only obtain their own blood coagulation data through the blood coagulation instrument, but also interact with the data center to obtain more professional guidance from doctors.
  • FIG. 1 is a schematic structural view of a blood coagulation apparatus according to an embodiment
  • FIG. 2 is a diagram of a detector module of an embodiment
  • FIG. 3 is a flow chart of a method for detecting a detector of an embodiment
  • FIG. 4 is a diagram of a detector module of another embodiment
  • Figure 5 is a circuit schematic diagram of the detector of the embodiment shown in Figure 4.
  • FIG. 6 is a flow chart of a method for measuring blood clotting time according to another embodiment
  • FIG. 7 is a block diagram of a medical system for preventing thrombosis in a network hospital according to an embodiment.
  • the blood coagulation apparatus includes a blood collection device 1 and a detector 2.
  • the blood collection device 1 is a semi-closed tubular member having a magnetically conductive metal bead 101 therein for collecting and containing blood; after collecting blood, the magnetic conductive metal bead 101 is immersed in the blood.
  • the detector 2 includes a main controller 10, at least two magnetic field circuits 20, and an inductive circuit 30.
  • the main controller 10 is electrically connected to the at least two magnetic field circuits 20 and the induction circuit 30, respectively.
  • the detector 2 further includes at least two U-shaped brackets 80 arranged in parallel, the magnetic field circuit 20 is in one-to-one correspondence with the U-shaped bracket 80, and the inductance coil of the magnetic field circuit 20 is attached to the U-shaped bracket. 80 forms a U shape.
  • the sensing circuit 30 is disposed on the outer U-shaped bracket 80.
  • the magnetic field circuit 20 can generate a magnetic field to drive the magnetic metal bead 101 to move.
  • the signal outputted by the sensing circuit 30 is different.
  • the method of measuring blood coagulation time includes the following steps.
  • Step S110 Initialize at least two position values corresponding to the at least two magnetic field circuits. For each magnetic field circuit 20. The main controller 10 activates the magnetic field circuit 20 to generate a magnetic field. This magnetic field will drive the magnetically conductive metal bead 101 into the magnetic field generated by the currently activated magnetic field circuit 20 and fix the position.
  • the main controller 10 activates the sensing circuit 30 to measure an output signal of the sensing circuit 30 when the magnetically conductive metal bead 101 is located in a magnetic field generated by the currently activated magnetic field circuit 20 as the currently activated magnetic field circuit 20 Corresponding position value.
  • Step S120 sequentially starting the at least two magnetic field circuits alternately to generate at least two alternating magnetic field driving metal beads for reciprocating motion; and simultaneously starting timing.
  • the magnetic field circuit 20 is sequentially activated from left to right in FIG. 1, and after the start of the rightmost magnetic field circuit 20 is completed, the magnetic field circuit 20 is sequentially activated from right to left.
  • Step S130 When the time interval of the metal bead passing the same distance is greater than a preset value, the timing ends, and the time is obtained.
  • the sensing circuit 30 can detect the corresponding position value.
  • the blood coagulation time is detected, since the blood gradually solidifies, the resistance to the magnetic metal beads 101 gradually increases, and the time during which the magnetic metal beads 101 pass the same distance becomes longer and longer.
  • the time is greater than the preset value, the blood has solidified.
  • the detector includes a main controller 100, a first magnetic field circuit 200, a second magnetic field circuit 300, a sensing circuit 400, a reset circuit 500, an oscillating circuit 600, and a display circuit 700.
  • the main controller 100 is electrically connected to the first magnetic field circuit 200, the second magnetic field circuit 300, and the sensing circuit 400, respectively, and the main controller 100 outputs a pulse width modulation signal to control the first magnetic field circuit 200 and the second magnetic field.
  • the circuit 300 alternately generates a magnetic field while receiving an output signal of the sensing circuit 400.
  • the main controller 100 is an 8051 single chip microcomputer.
  • the first magnetic field circuit 200 includes a first resistor R3, a first transistor VT1, a first diode D2, and a first inductor L1; the first diode D2 is connected in parallel with the first inductor L1; a cathode of the first diode D2 is connected to a positive pole of the power supply VCC, a cathode of the first diode D2 is connected to a collector of the first transistor VT1; and a cathode of the first transistor VT1 is The base is connected to one of the PWM signal output terminals (AD3/P0.3) of the 8051 microcontroller through the first resistor R3, and the emitter of the first transistor VT1 is grounded.
  • AD3/P0.3 the PWM signal output terminals
  • the second magnetic field circuit 300 includes a second resistor R4, a second transistor VT2, a second diode D3, and a second inductor L2; the second diode D3 is connected in parallel with the second inductor L2; The cathode of the second diode D3 is connected to the positive pole of the power supply VCC, the anode of the second diode D3 is connected to the collector of the second transistor VT2, and the cathode of the second transistor VT2 is The base is connected to the other PWM signal output terminal (AD2/P0.2) of the 8051 microcontroller through the first resistor R3, and the emitter of the second transistor VT2 is grounded.
  • AD2/P0.2 PWM signal output terminal
  • the sensing circuit 400 includes a third resistor R5, a fourth resistor R8, a fifth resistor R6, a sixth resistor R7, a first capacitor C4, a second capacitor C5, a third transistor VT3, and a third inductor coil;
  • the collector of the third transistor VT3 is connected to one of the signal input terminals (AD0/P0.0) of the 8051 microcontroller through a third resistor R5; the collector of the third transistor VT3 also passes through the fourth resistor R8 is connected to the positive power supply VCC;
  • the base of the third transistor VT3 is connected to one of the control signal output terminals (AD1/P0.1) of the 8051 single chip through a fifth resistor R6;
  • the base of the pole tube VT3 is also connected to the positive pole of the power supply VCC through the sixth resistor R7; the base of the third transistor VT3 is also grounded through the first capacitor C4 and the second capacitor C5 connected in series; the third inductor One end of the coil is connected to the common end
  • the reset circuit 500 includes a third capacitor C1, a first switch S1, and a seventh resistor R2.
  • the third capacitor C1 and the first switch S1 are connected in parallel with the seventh resistor R2 in series with the power supply VCC positive and ground.
  • One end of the seventh resistor R2 that is not grounded is connected to the reset terminal RST of the 8051 one-chip computer.
  • the oscillating circuit 600 includes a crystal oscillator X1, a fourth capacitor C3, and a fifth capacitor C2.
  • the fourth capacitor C3 is connected between the first clock terminal XTAL1 of the 8051 microcontroller and ground; the fifth capacitor C2 is connected to The second clock terminal XTAL2 of the 8051 microcontroller is connected to the ground; the crystal oscillator X1 is connected between the first clock terminal XTAL1 and the second clock terminal XTAL2.
  • the position value includes a first position value and a second position value. Then the above step S130 includes:
  • the main controller 100 activates the first magnetic field circuit 200 and determines whether the output signal of the sensing circuit 300 reaches the first position value within a preset time, and if so, the main controller 100 activates the second magnetic field The circuit 300 and the first magnetic field circuit 200 is turned off; Otherwise, it is determined that the time interval at which the metal beads reach the same position twice is greater than a preset value.
  • the main controller 100 After the main controller 100 activates the second magnetic field circuit 300, it is determined whether the output signal of the sensing circuit 400 reaches the second position value within a preset time, and if so, the main controller 100 starts the first magnetic field.
  • the circuit 200 closes the second magnetic field circuit 300; otherwise, it is determined that the time interval at which the metal beads reach the same position twice is greater than a preset value.
  • the timing is output.
  • the at least two position values further include a third position value and a fourth position value between the first position value and the second position value, and the position values are all
  • the sensing circuit 400 outputs a period of the signal.
  • Third position value (second position value - first position value) / 4 + first position value
  • the fourth position value (first position value - second position value) / 4 + second position value.
  • step S130 includes:
  • Step A The main controller 100 activates the first magnetic field circuit 200 and initializes the count value to zero. For example, the count variable is used to save the count value.
  • Step B After waiting for the preset sub-period, the main controller 100 measures the period of the output signal of the sensing circuit 400.
  • the preset value is 1 second, and the preset sub-period can be 100 milliseconds (ms).
  • Step D determining whether the count value exceeds the pre-designed value, and if so, outputting the timing time, otherwise it is further determined whether the period of the output signal of the sensing circuit 400 is smaller than the third position value.
  • the pre-designed value corresponds to the preset value. For example, if the preset value is 1 second and the preset sub-time period is 100 milliseconds, the preset count value is 10. That is, it is judged whether count is greater than 10.
  • step E is performed.
  • the third position value reflects the position of the metal bead adjacent to the first magnetic field circuit 200. If the period of the output signal of the sensing circuit 400 is less than the value, it indicates that the metal bead continues to approach the first magnetic field circuit 200.
  • Step E The main controller 100 activates the second magnetic field circuit 300 to initialize the count value to zero. After the above steps B ⁇ D, if the period of the output signal of the sensing circuit 400 is greater than the third position value, the metal bead approaches the second magnetic field circuit. In this case, reset the count value to 0.
  • Step F After waiting for the preset sub-period, the main controller 100 measures the period of the output signal of the sensing circuit 400.
  • the preset value is 1 second, and the preset sub-period can be 100 milliseconds (ms).
  • Step H determining whether the count value exceeds the pre-designed value, and if so, outputting the timing time, otherwise it is further determined whether the period of the output signal of the sensing circuit 400 is smaller than the fourth position value.
  • the pre-designed value corresponds to the preset value. For example, if the preset value is 1 second and the preset sub-time period is 100 milliseconds, the preset count value is 10. That is, it is judged whether count is greater than 10.
  • step A is performed.
  • the fourth position value reflects the position of the metal bead adjacent to the second magnetic field circuit 300. If the period of the output signal of the sensing circuit 400 is less than the value, it indicates that the metal bead continues to approach the second magnetic field circuit 300.
  • a medical system for preventing thrombosis in a network hospital of an embodiment is provided.
  • the medical system for preventing thrombus in the network hospital includes the blood coagulation apparatus, the communication device 50, and the data center 60 of the above embodiment.
  • Communication device 50 collects data from the coagulometer and sends it to data center 60, which processes and manages the received data.
  • the blood coagulation apparatus includes a wireless communication module 40 that wirelessly collects data of the blood coagulation apparatus.
  • the wireless communication module 40 can be a Bluetooth module or a wifi module
  • the communication device 50 is a smart terminal, such as a smart phone, a tablet or a notebook.
  • the data of the blood coagulation instrument may include blood coagulation time of the current test, test time, relevant information of the test person, and the like.
  • the data center 60 processes and manages the blood coagulation data, can form historical data of the patient, and generates related reports, conclusions, charts, and the like according to the historical data, which helps to track the physical condition of the patient.
  • the data center 60 can also assign patient data to the physician user, who can obtain professional advice and guidance based on the patient's condition after obtaining the authority to view the patient data.
  • Data center 60 also includes feedback device 610.
  • the feedback device 610 communicates with the communication device 50 and transmits the processing result of the data center to the communication device 50.
  • the physician user can also feed back their suggestions and guidance information to the patient via feedback device 610.
  • the above-mentioned network hospital is used for the prevention of blood clots, so that patients can not only obtain their own blood coagulation data through the blood coagulation instrument, but also interact with the data center to obtain more professional guidance from doctors.

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Abstract

L'invention concerne un système médical d'hôpital en réseau et de coagulomètre pour prévenir une thrombose, le coagulomètre comprenant un collecteur de sang (1) et un détecteur (2); le collecteur de sang (1) est un élément tubulaire semi-fermé pour obtenir et contenir du sang, une bille métallique magnétique (101) étant disposée dans l'élément tubulaire semi-fermé; une fois que le sang est obtenu, la bille métallique magnétique (101) est immergée dans le sang; le détecteur (2) comprend une unité de commande principale (10), au moins deux circuits de champ magnétique (20) et un circuit d'induction (30), l'unité de commande principale (10) étant reliée électriquement aux au moins deux circuits de champ magnétique (20) et au circuit d'induction (30), respectivement, et commandant les au moins deux circuits de champ magnétique (20) pour générer alternativement et successivement un champ magnétique, et recevoir simultanément un signal de sortie du circuit d'induction (30); le détecteur (2) détermine une coagulation sanguine par l'intermédiaire des au moins deux circuits de champ magnétique (20) entraînant la bille métallique magnétique (101) pour réaliser un mouvement de va-et-vient dans l'élément tubulaire, et par l'intermédiaire du circuit d'induction (30) détectant un mouvement de la bille métallique magnétique (101). Le coagulomètre a une structure simple et une mesure précise, et le système médical permet à un patient d'obtenir des conseils professionnels auprès de plusieurs médecins.
PCT/CN2014/093627 2014-12-06 2014-12-11 Système médical d'hôpital en réseau et de coagulomètre pour prévenir une thrombose WO2016086444A1 (fr)

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CN201410737792.0A CN104545943B (zh) 2014-12-06 2014-12-06 血凝仪以及网络医院用于预防血栓的医疗系统
CN201410737792.0 2014-12-06

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Cited By (1)

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CN112881233A (zh) * 2019-11-29 2021-06-01 深圳市帝迈生物技术有限公司 液体状态检测装置、样本分析仪

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CN104568665B (zh) * 2014-12-06 2017-07-07 深圳市前海安测信息技术有限公司 测量液体凝滞时间的方法
CN107505454A (zh) * 2017-06-23 2017-12-22 世纪亿康（天津）医疗科技发展有限公司 一种凝血及血小板功能检测的反应体系及其应用

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US4918984A (en) * 1987-12-30 1990-04-24 Serbio Device for measuring the modification time of the physical state of a fluid medium
CN202256355U (zh) * 2011-09-15 2012-05-30 天津美德太平洋科技有限公司 检测全血标本凝血项目的血凝仪
CN202676709U (zh) * 2012-02-08 2013-01-16 南京柯伦迪检测技术有限公司 一种新型的全血血凝功能分析仪
CN204359734U (zh) * 2014-12-06 2015-05-27 深圳市易特科信息技术有限公司 血凝仪及其应用于网络医院的医疗系统

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Publication number Priority date Publication date Assignee Title
US4918984A (en) * 1987-12-30 1990-04-24 Serbio Device for measuring the modification time of the physical state of a fluid medium
CN202256355U (zh) * 2011-09-15 2012-05-30 天津美德太平洋科技有限公司 检测全血标本凝血项目的血凝仪
CN202676709U (zh) * 2012-02-08 2013-01-16 南京柯伦迪检测技术有限公司 一种新型的全血血凝功能分析仪
CN204359734U (zh) * 2014-12-06 2015-05-27 深圳市易特科信息技术有限公司 血凝仪及其应用于网络医院的医疗系统

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112881233A (zh) * 2019-11-29 2021-06-01 深圳市帝迈生物技术有限公司 液体状态检测装置、样本分析仪

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