WO2016065444A1 - Procédé d'obtention de transporteurs lipidiques nanostructurés en copolymère tribloc, transporteurs lipidiques nanostructurés ainsi obtenus et leurs utilisations - Google Patents
Procédé d'obtention de transporteurs lipidiques nanostructurés en copolymère tribloc, transporteurs lipidiques nanostructurés ainsi obtenus et leurs utilisations Download PDFInfo
- Publication number
- WO2016065444A1 WO2016065444A1 PCT/BR2015/000121 BR2015000121W WO2016065444A1 WO 2016065444 A1 WO2016065444 A1 WO 2016065444A1 BR 2015000121 W BR2015000121 W BR 2015000121W WO 2016065444 A1 WO2016065444 A1 WO 2016065444A1
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- WO
- WIPO (PCT)
- Prior art keywords
- cln
- carrier
- oil
- nanostructured lipid
- nanostructured
- Prior art date
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- 150000002632 lipids Chemical class 0.000 title claims abstract description 149
- 229920000428 triblock copolymer Polymers 0.000 title claims abstract description 19
- 239000000969 carrier Substances 0.000 title claims description 39
- 238000004519 manufacturing process Methods 0.000 title abstract description 4
- 238000000034 method Methods 0.000 claims abstract description 44
- 210000004209 hair Anatomy 0.000 claims abstract description 43
- 239000000203 mixture Substances 0.000 claims abstract description 34
- 239000007787 solid Substances 0.000 claims abstract description 34
- 239000007788 liquid Substances 0.000 claims abstract description 30
- 239000002537 cosmetic Substances 0.000 claims abstract description 21
- 229920001983 poloxamer Polymers 0.000 claims abstract description 20
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims abstract description 10
- 229920000642 polymer Polymers 0.000 claims abstract description 9
- 229960000502 poloxamer Drugs 0.000 claims abstract description 8
- 229920001993 poloxamer 188 Polymers 0.000 claims description 41
- HQPMKSGTIOYHJT-UHFFFAOYSA-N ethane-1,2-diol;propane-1,2-diol Chemical compound OCCO.CC(O)CO HQPMKSGTIOYHJT-UHFFFAOYSA-N 0.000 claims description 40
- 239000004166 Lanolin Substances 0.000 claims description 38
- 229940039717 lanolin Drugs 0.000 claims description 38
- 235000019388 lanolin Nutrition 0.000 claims description 37
- 230000008569 process Effects 0.000 claims description 32
- 235000014121 butter Nutrition 0.000 claims description 26
- 235000021390 Buriti oil Nutrition 0.000 claims description 25
- 230000003711 photoprotective effect Effects 0.000 claims description 15
- 239000000839 emulsion Substances 0.000 claims description 10
- 239000003921 oil Substances 0.000 claims description 10
- 235000019198 oils Nutrition 0.000 claims description 10
- 238000013019 agitation Methods 0.000 claims description 8
- 239000002245 particle Substances 0.000 claims description 7
- 238000001816 cooling Methods 0.000 claims description 6
- 229920001577 copolymer Polymers 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 claims description 5
- 230000004927 fusion Effects 0.000 claims description 5
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 5
- 229920000053 polysorbate 80 Polymers 0.000 claims description 5
- 244000288157 Passiflora edulis Species 0.000 claims description 4
- 235000000370 Passiflora edulis Nutrition 0.000 claims description 4
- 229920002125 Sokalan® Polymers 0.000 claims description 4
- 235000019486 Sunflower oil Nutrition 0.000 claims description 4
- 239000010478 argan oil Substances 0.000 claims description 4
- 235000021302 avocado oil Nutrition 0.000 claims description 4
- 239000008163 avocado oil Substances 0.000 claims description 4
- 235000019480 chamomile oil Nutrition 0.000 claims description 4
- 239000010628 chamomile oil Substances 0.000 claims description 4
- 235000019864 coconut oil Nutrition 0.000 claims description 4
- 239000003240 coconut oil Substances 0.000 claims description 4
- 239000002600 sunflower oil Substances 0.000 claims description 4
- 244000205479 Bertholletia excelsa Species 0.000 claims description 3
- 239000004909 Moisturizer Substances 0.000 claims description 3
- 229920001400 block copolymer Polymers 0.000 claims description 3
- 239000006071 cream Substances 0.000 claims description 3
- 239000006210 lotion Substances 0.000 claims description 3
- 230000001333 moisturizer Effects 0.000 claims description 3
- 239000010466 nut oil Substances 0.000 claims description 3
- 235000012284 Bertholletia excelsa Nutrition 0.000 claims description 2
- 235000019488 nut oil Nutrition 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 238000000265 homogenisation Methods 0.000 abstract description 8
- 230000009467 reduction Effects 0.000 abstract description 5
- 230000014759 maintenance of location Effects 0.000 abstract description 3
- 239000002105 nanoparticle Substances 0.000 description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 20
- 239000000835 fiber Substances 0.000 description 14
- 244000141804 Theobroma grandiflorum Species 0.000 description 13
- 239000004094 surface-active agent Substances 0.000 description 12
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- 238000005516 engineering process Methods 0.000 description 7
- 238000002844 melting Methods 0.000 description 5
- 230000008018 melting Effects 0.000 description 5
- 239000002086 nanomaterial Substances 0.000 description 5
- 210000003491 skin Anatomy 0.000 description 5
- 239000003381 stabilizer Substances 0.000 description 5
- 230000008901 benefit Effects 0.000 description 4
- 235000014113 dietary fatty acids Nutrition 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- 239000000194 fatty acid Substances 0.000 description 4
- 229930195729 fatty acid Natural products 0.000 description 4
- 150000004665 fatty acids Chemical class 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 230000004224 protection Effects 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 239000003937 drug carrier Substances 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 230000036571 hydration Effects 0.000 description 3
- 238000006703 hydration reaction Methods 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 239000002159 nanocrystal Substances 0.000 description 3
- 239000002047 solid lipid nanoparticle Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- PZNPLUBHRSSFHT-RRHRGVEJSA-N 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[C@@H](COP([O-])(=O)OCC[N+](C)(C)C)COC(=O)CCCCCCCCCCCCCCC PZNPLUBHRSSFHT-RRHRGVEJSA-N 0.000 description 2
- 239000010472 acai oil Substances 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005538 encapsulation Methods 0.000 description 2
- YJGVMLPVUAXIQN-UHFFFAOYSA-N epipodophyllotoxin Natural products COC1=C(OC)C(OC)=CC(C2C3=CC=4OCOC=4C=C3C(O)C3C2C(OC3)=O)=C1 YJGVMLPVUAXIQN-UHFFFAOYSA-N 0.000 description 2
- 210000003128 head Anatomy 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 239000002077 nanosphere Substances 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- YJGVMLPVUAXIQN-XVVDYKMHSA-N podophyllotoxin Chemical compound COC1=C(OC)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@H](O)[C@@H]3[C@@H]2C(OC3)=O)=C1 YJGVMLPVUAXIQN-XVVDYKMHSA-N 0.000 description 2
- 229960001237 podophyllotoxin Drugs 0.000 description 2
- YVCVYCSAAZQOJI-UHFFFAOYSA-N podophyllotoxin Natural products COC1=C(O)C(OC)=CC(C2C3=CC=4OCOC=4C=C3C(O)C3C2C(OC3)=O)=C1 YVCVYCSAAZQOJI-UHFFFAOYSA-N 0.000 description 2
- 239000002453 shampoo Substances 0.000 description 2
- 239000008347 soybean phospholipid Substances 0.000 description 2
- 230000000699 topical effect Effects 0.000 description 2
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 206010001488 Aggression Diseases 0.000 description 1
- 201000004384 Alopecia Diseases 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- 244000042664 Matricaria chamomilla Species 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 230000016571 aggressive behavior Effects 0.000 description 1
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 235000013734 beta-carotene Nutrition 0.000 description 1
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 1
- 239000011648 beta-carotene Substances 0.000 description 1
- 229960002747 betacarotene Drugs 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 235000020113 brazil nut Nutrition 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 239000002872 contrast media Substances 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
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- 238000011161 development Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 210000005095 gastrointestinal system Anatomy 0.000 description 1
- 230000003676 hair loss Effects 0.000 description 1
- 230000003760 hair shine Effects 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 230000001050 lubricating effect Effects 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 230000002132 lysosomal effect Effects 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 238000010907 mechanical stirring Methods 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 235000021313 oleic acid Nutrition 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 229940044519 poloxamer 188 Drugs 0.000 description 1
- 229920000193 polymethacrylate Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229950008882 polysorbate Drugs 0.000 description 1
- 238000011176 pooling Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
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- 238000004626 scanning electron microscopy Methods 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 230000036561 sun exposure Effects 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/90—Block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/12—Preparations containing hair conditioners
Abstract
La présente invention concerne un procédé d'obtention d'un transporteur lipidique nanostructuré (NLC) en copolymère tribloc par homogénéisation à chaud sous des pressions élevées. L'invention concerne également le transporteur lipidique nanostructuré en copolymère tribloc obtenu au moyen dudit procédé. En outre, la présente invention concerne le NLC, comprenant un mélange d'un lipide liquide avec deux lipides solides, conjointement avec le copolymère tribloc, sélectionné dans la famille des polymères poloxamères. L'invention trouve une utilisation en cosmétique, notamment pour application sur les cheveux, contribuant à retenir l'humidité dans les fibres capillaires pendant une durée prolongée, à réduire la frisure et à augmenter l'éclat.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BRBR1020140280022 | 2014-10-31 | ||
| BR102014028002A BR102014028002B1 (pt) | 2014-10-31 | 2014-10-31 | processo de obtenção de carreadores lipídicos nanoestruturados em copolímero tribloco, carreadores lipídicos nanoestruturados assim obtidos, e seus usos |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2016065444A1 true WO2016065444A1 (fr) | 2016-05-06 |
Family
ID=55856295
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/BR2015/000121 WO2016065444A1 (fr) | 2014-10-31 | 2015-08-04 | Procédé d'obtention de transporteurs lipidiques nanostructurés en copolymère tribloc, transporteurs lipidiques nanostructurés ainsi obtenus et leurs utilisations |
Country Status (2)
| Country | Link |
|---|---|
| BR (1) | BR102014028002B1 (fr) |
| WO (1) | WO2016065444A1 (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017185147A1 (fr) | 2016-04-25 | 2017-11-02 | L'oreal | Transporteurs lipidiques nanostructurés et leurs procédés de fabrication et d'utilisation |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040109894A1 (en) * | 2002-12-09 | 2004-06-10 | Adi Shefer | PH triggered targeted controlled release systems for the delivery of pharmaceutical active ingredients |
| WO2007078060A1 (fr) * | 2005-12-30 | 2007-07-12 | Amorepacific Corporation | Nanocomplexes polymere-liposome et leur procede de preparation, et composition de l'application cutanee externe les contenant |
| WO2008058755A1 (fr) * | 2006-11-17 | 2008-05-22 | Abbott Gmbh & Co. Kg | Nanocristaux pour une utilisation dans des formulations cosmétiques topiques et leur procédé de fabrication |
| WO2010040194A2 (fr) * | 2008-10-10 | 2010-04-15 | Biolab Sanus Farmacêutica Ltda | Système à nanoparticules, son procédé de préparation, son utilisation, composition photoprotectrice, son procédé de préparation, méthode de prévention des maladies de peau |
| WO2011068476A1 (fr) * | 2009-12-01 | 2011-06-09 | Creative Technology Ltd | Procédé de mise en vitrine d'une structure assemblée et appareil de mise en oeuvre de ce procédé |
| WO2011116963A2 (fr) * | 2010-03-24 | 2011-09-29 | Lipotec S.A. | Capsules de nanoparticules de lipide |
| US20150224035A1 (en) * | 2011-09-23 | 2015-08-13 | Indian Institute Of Technology | Nanoparticle based cosmetic composition |
-
2014
- 2014-10-31 BR BR102014028002A patent/BR102014028002B1/pt active IP Right Grant
-
2015
- 2015-08-04 WO PCT/BR2015/000121 patent/WO2016065444A1/fr active Application Filing
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040109894A1 (en) * | 2002-12-09 | 2004-06-10 | Adi Shefer | PH triggered targeted controlled release systems for the delivery of pharmaceutical active ingredients |
| WO2007078060A1 (fr) * | 2005-12-30 | 2007-07-12 | Amorepacific Corporation | Nanocomplexes polymere-liposome et leur procede de preparation, et composition de l'application cutanee externe les contenant |
| WO2008058755A1 (fr) * | 2006-11-17 | 2008-05-22 | Abbott Gmbh & Co. Kg | Nanocristaux pour une utilisation dans des formulations cosmétiques topiques et leur procédé de fabrication |
| WO2010040194A2 (fr) * | 2008-10-10 | 2010-04-15 | Biolab Sanus Farmacêutica Ltda | Système à nanoparticules, son procédé de préparation, son utilisation, composition photoprotectrice, son procédé de préparation, méthode de prévention des maladies de peau |
| WO2011068476A1 (fr) * | 2009-12-01 | 2011-06-09 | Creative Technology Ltd | Procédé de mise en vitrine d'une structure assemblée et appareil de mise en oeuvre de ce procédé |
| WO2011116963A2 (fr) * | 2010-03-24 | 2011-09-29 | Lipotec S.A. | Capsules de nanoparticules de lipide |
| US20150224035A1 (en) * | 2011-09-23 | 2015-08-13 | Indian Institute Of Technology | Nanoparticle based cosmetic composition |
Non-Patent Citations (1)
| Title |
|---|
| DINI, A . X. P. ET AL.: "Aplicação de lipidios nacionais na produção de carreador lipidico nanoestruturado e sua aplicação em cabelos.", PIBIC UNICAMP, 2012 * |
Also Published As
| Publication number | Publication date |
|---|---|
| BR102014028002B1 (pt) | 2019-10-22 |
| BR102014028002A2 (pt) | 2016-05-24 |
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