WO2016062020A9 - 茯苓多糖活性组分和成分、其制备方法及用途 - Google Patents

茯苓多糖活性组分和成分、其制备方法及用途 Download PDF

Info

Publication number
WO2016062020A9
WO2016062020A9 PCT/CN2015/075761 CN2015075761W WO2016062020A9 WO 2016062020 A9 WO2016062020 A9 WO 2016062020A9 CN 2015075761 W CN2015075761 W CN 2015075761W WO 2016062020 A9 WO2016062020 A9 WO 2016062020A9
Authority
WO
WIPO (PCT)
Prior art keywords
ingredients
polysaccharide
poria
preparation
relates
Prior art date
Application number
PCT/CN2015/075761
Other languages
English (en)
French (fr)
Other versions
WO2016062020A1 (zh
Inventor
单俊杰
王玉霞
李帅
李海霞
巫亚俊
麻浩
贾培媛
武军华
刘坤璐
刘圆圆
张永平
Original Assignee
北京中安佐际生物科技有限公司
中国人民解放军军事医学科学院毒物药物研究所
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 北京中安佐际生物科技有限公司, 中国人民解放军军事医学科学院毒物药物研究所 filed Critical 北京中安佐际生物科技有限公司
Publication of WO2016062020A1 publication Critical patent/WO2016062020A1/zh
Publication of WO2016062020A9 publication Critical patent/WO2016062020A9/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Polymers & Plastics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials Engineering (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

本发明涉及从茯苓中提取的多糖，具体涉及从茯苓中提取的多糖组分A和B及多糖成分Ⅰ和Ⅱ及其组合物；本发明还涉及多糖组分A和B及多糖成分Ⅰ和Ⅱ的制备方法；以及所述多糖组分或成分作为佐剂、疫苗辅料或免疫调节剂，或用于制备疫苗制剂或抗体的用途。活性实验结果表明茯苓多糖组分A和B、多糖成分Ⅰ和Ⅱ均具有免疫佐剂活性和免疫调节作用，为佐剂、免疫调节剂或疫苗辅料或制备疫苗制剂或抗体提供了新的选择。
PCT/CN2015/075761 2014-10-22 2015-04-02 茯苓多糖活性组分和成分、其制备方法及用途 WO2016062020A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201410566069.0A CN105585638B (zh) 2014-10-22 2014-10-22 茯苓多糖活性组分和成分、其制备方法及用途
CN201410566069.0 2014-10-22

Publications (2)

Publication Number Publication Date
WO2016062020A1 WO2016062020A1 (zh) 2016-04-28
WO2016062020A9 true WO2016062020A9 (zh) 2016-05-26

Family

ID=55760182

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2015/075761 WO2016062020A1 (zh) 2014-10-22 2015-04-02 茯苓多糖活性组分和成分、其制备方法及用途

Country Status (2)

Country Link
CN (1) CN105585638B (zh)
WO (1) WO2016062020A1 (zh)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107801981B (zh) * 2017-10-19 2020-09-29 广州泽力医药科技有限公司 凝胶型茯苓产品及其制备方法和应用
CN109232768A (zh) * 2018-08-31 2019-01-18 华南理工大学 一种具有抗炎症性肠病活性的羧甲基茯苓多糖及其制备与应用
CN112089834B (zh) * 2020-10-26 2022-11-18 北京工业大学 基于氧化石墨烯的茯苓多糖纳米佐剂及佐剂/抗原共递送疫苗的制备与应用
CN112225831B (zh) * 2020-11-03 2022-03-01 华中农业大学 一种活性茯苓多糖、其制备方法及应用
CN113912751A (zh) * 2021-12-01 2022-01-11 上海市农业科学院 一种富含半乳糖的灵芝孢子粉多糖及其制备方法
CN115232221B (zh) * 2022-05-31 2023-11-17 海南医学院 具有防治肺部感染的薜荔多糖及其制备方法与应用
CN115028752B (zh) * 2022-06-24 2023-04-07 黑龙江葵花药业股份有限公司 一种均一的水溶性多糖及其制备方法和应用
CN115176890A (zh) * 2022-06-29 2022-10-14 瑞普高科(天津)生物技术有限公司 茯苓β-1,3-D-葡聚糖在制备提高生长性能的饲料添加剂中的用途
CN115611993B (zh) * 2022-10-27 2023-07-18 常熟理工学院 一种枸杞多糖的提取方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1483827A (zh) * 2002-09-16 2004-03-24 上海大杨保健品科技发展有限公司 一种活性茯苓多糖的制备方法
CN1205231C (zh) * 2003-01-06 2005-06-08 武汉大学 一种具有抗肿瘤活性的水溶性杂多糖及其制备方法和用途
CN1205230C (zh) * 2003-01-06 2005-06-08 武汉大学 一种水溶性杂多糖及其制备方法和用途
CN101711778B (zh) * 2008-10-07 2011-12-07 天津中医药大学 用于抑制肿瘤和防治转移及复发的茯苓多糖组合物与应用
CN102399299B (zh) * 2011-12-05 2013-05-22 湖北泱盛生物科技有限公司 一种茯苓酸性多糖提取物的制备方法及应用
CN105237649B (zh) * 2014-07-11 2018-01-16 中国人民解放军军事医学科学院毒物药物研究所 一种茯苓多糖、其制备方法及用途

Also Published As

Publication number Publication date
CN105585638B (zh) 2017-12-15
WO2016062020A1 (zh) 2016-04-28
CN105585638A (zh) 2016-05-18

Similar Documents

Publication Publication Date Title
WO2016062020A9 (zh) 茯苓多糖活性组分和成分、其制备方法及用途
WO2016019134A8 (en) Flagellin-based agents and uses including effective vaccination
WO2015168379A3 (en) Combination vaccine devices and methods of killing cancer cells
WO2017070616A3 (en) Sexually transmitted disease vaccines
WO2016201049A3 (en) Formulations for neoplasia vaccines and methods of preparing them
WO2017070620A3 (en) Broad spectrum influenza virus vaccine
WO2015018380A3 (en) Therapeutic nanoparticles and the preparation methods thereof
WO2015042369A3 (en) Oil-based adjuvants
WO2015103167A3 (en) Single vial vaccine formulations
WO2016179034A3 (en) Methods and compositions for stimulating immune response using potent immunostimulatory rna motifs
PH12018000197A1 (en) Hand, foot, and mouth vaccines and methods of manufacture and use thereof
SG11202003796XA (en) Zika vaccines and immunogenic compositions, and methods of using the same
PH12015501716B1 (en) Anti-mycoplasma spp. subunit vaccine
MX2016016746A (es) Composiciones de vacuna con adyuvante dual, preparacion y usos.
MX2017002803A (es) Coronavirus bovino atenuado y vacunas relacionadas.
MY174991A (en) Eurycoma longifolia extract and its use in enhancing and/or stimulating immune system
WO2016126876A3 (en) Listeria-based adjuvants
WO2016207853A3 (en) Antigenically matched influenza vaccines
WO2015061798A3 (en) Compositions and methods comprising yeast organisms and lipid extracts thereof
MX2021013109A (es) Proceso de preparacion de una vacuna tetravalente atenuada contra el virus del dengue.
EP3717511A4 (en) ZIKA VIRUS VACCINES, IMMUNOGENIC COMPOSITIONS AND THEIR USE PROCEDURES
WO2015123493A3 (en) Compositions and methods for modulatuion of immune response
EP3939604A3 (en) Influenza hemagglutinin protein vaccines
IL286254A (en) tlr4 and tlr7 ligand formulations as vaccine adjuvants
WO2015149016A3 (en) Breast and ovarian cancer vaccines

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 15852567

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase in:

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 15852567

Country of ref document: EP

Kind code of ref document: A1