WO2016060543A1 - Système et méthode pour extraire le déphasage d'un signal de fluorescence - Google Patents

Système et méthode pour extraire le déphasage d'un signal de fluorescence Download PDF

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Publication number
WO2016060543A1
WO2016060543A1 PCT/MY2015/050059 MY2015050059W WO2016060543A1 WO 2016060543 A1 WO2016060543 A1 WO 2016060543A1 MY 2015050059 W MY2015050059 W MY 2015050059W WO 2016060543 A1 WO2016060543 A1 WO 2016060543A1
Authority
WO
WIPO (PCT)
Prior art keywords
signal
phase
quadrature
fluorescence
voltage signal
Prior art date
Application number
PCT/MY2015/050059
Other languages
English (en)
Inventor
Tengku Azhar LONG SULAIMAN
Noorsuriati MOHD ZAINAL ARIFFIN
Mohamad Faisal Jaafar Ng
Original Assignee
Mimos Berhad
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mimos Berhad filed Critical Mimos Berhad
Publication of WO2016060543A1 publication Critical patent/WO2016060543A1/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/12—Circuits of general importance; Signal processing
    • G01N2201/124—Sensitivity

Definitions

  • the photo detector (50) converts the fluorescence signal, Y(t) to electrical current signal and thereon, the photo detector (50) mixes the electrical current, Y(t) with either the in-phase signal, X(t) or the quadrature signal, X q (t). The resulted mixed signal of X(t) and Y(t) or X q (t) and Y(t) is then routed through the LPF (70). Thus, the photo detector (50) is connected to the RF switch (60) and the LPF (70).
  • the FGU (10) generates the known in-phase signal, X,(t), and supplies the known in-phase signal, X,(t), to the LED (20) as in step 200.
  • the in-phase signal is also supplied to the phase shifter (40) and the RF switch (60).
  • the result of the multiplication is then routed through the LPF (70) to remove the high order mixing products.
  • the multiplied signal is further converted by the TIA (80) from current to in-phase voltage signal, Vj(t). Thereon, the in-phase voltage signal, V,(t), is stored in a digital processor.
  • phase shift information denotes the amount of specimen present in a medium as being sensed by the sensor element (30) such as the concentration level of dissolved oxygen or dissolved ammonia.

Landscapes

  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

La présente invention concerne un système (100) et un procédé pour extraire le déphasage d'un signal de fluorescence. Le système (100) comprend une Unité de Génération de fréquence ou FGU (10), une diode électroluminescente ou DEL (20), un élément de capteur (30), un déphaseur (40), un photo-détecteur (50), un commutateur radiofréquence (RF) (60), un filtre passe-bas (LPF) (70), un amplificateur de trans-impédance (TIA) (80), et un processeur numérique (non représenté). Le photodétecteur (50) est configuré pour convertir un signal de fluorescence provenant de l'élément de capteur (30) en un signal de courant électrique et également pour multiplier le signal de fluorescence avec soit le signal en quadrature ou le signal en phase connu tel que sélectionné par le commutateur RF (60).
PCT/MY2015/050059 2014-10-13 2015-06-19 Système et méthode pour extraire le déphasage d'un signal de fluorescence WO2016060543A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
MYPI2014703006A MY181662A (en) 2014-10-13 2014-10-13 A system and method to extract phase shift of a fluorescence signal
MYPI2014703006 2014-10-13

Publications (1)

Publication Number Publication Date
WO2016060543A1 true WO2016060543A1 (fr) 2016-04-21

Family

ID=55746984

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/MY2015/050059 WO2016060543A1 (fr) 2014-10-13 2015-06-19 Système et méthode pour extraire le déphasage d'un signal de fluorescence

Country Status (2)

Country Link
MY (1) MY181662A (fr)
WO (1) WO2016060543A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112697762A (zh) * 2021-01-07 2021-04-23 中山复旦联合创新中心 一种高精度的溶氧仪系统与专用SoC

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010014505A1 (fr) * 2008-07-28 2010-02-04 Sensors For Medicine & Science, Inc. Systèmes et procédés de mesure optique de concentration d'analyte
US20110168917A1 (en) * 2008-09-19 2011-07-14 Mitsui Engineering & Shipbuilding Co., Ltd. Fluorescence detection device using intensity-modulated laser light and fluorescence detection method
US20120025098A1 (en) * 2009-02-13 2012-02-02 Mitsui Engineering & Shipbuilding Co., Ltd. Fluorescence detection device and fluorescence detection method
JP2013190221A (ja) * 2012-03-12 2013-09-26 Mitsui Eng & Shipbuild Co Ltd 蛍光検出装置及び蛍光検出方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010014505A1 (fr) * 2008-07-28 2010-02-04 Sensors For Medicine & Science, Inc. Systèmes et procédés de mesure optique de concentration d'analyte
US20110168917A1 (en) * 2008-09-19 2011-07-14 Mitsui Engineering & Shipbuilding Co., Ltd. Fluorescence detection device using intensity-modulated laser light and fluorescence detection method
US20120025098A1 (en) * 2009-02-13 2012-02-02 Mitsui Engineering & Shipbuilding Co., Ltd. Fluorescence detection device and fluorescence detection method
JP2013190221A (ja) * 2012-03-12 2013-09-26 Mitsui Eng & Shipbuild Co Ltd 蛍光検出装置及び蛍光検出方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112697762A (zh) * 2021-01-07 2021-04-23 中山复旦联合创新中心 一种高精度的溶氧仪系统与专用SoC

Also Published As

Publication number Publication date
MY181662A (en) 2020-12-31

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