WO2016047325A1 - Dispositif de remplissage de médicaments liquides - Google Patents

Dispositif de remplissage de médicaments liquides Download PDF

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Publication number
WO2016047325A1
WO2016047325A1 PCT/JP2015/073492 JP2015073492W WO2016047325A1 WO 2016047325 A1 WO2016047325 A1 WO 2016047325A1 JP 2015073492 W JP2015073492 W JP 2015073492W WO 2016047325 A1 WO2016047325 A1 WO 2016047325A1
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WO
WIPO (PCT)
Prior art keywords
chemical
filling
chemical solution
suction
storage unit
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Application number
PCT/JP2015/073492
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English (en)
Japanese (ja)
Inventor
内山　城司
Original Assignee
テルモ株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by テルモ株式会社 filed Critical テルモ株式会社
Priority to JP2016550037A priority Critical patent/JP6625994B2/ja
Publication of WO2016047325A1 publication Critical patent/WO2016047325A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes

Definitions

  • the present invention relates to a chemical solution filling device that fills a chemical solution storage part of a portable chemical solution administration device such as an insulin pump.
  • treatment methods have been performed in which a drug solution is continuously administered into a patient's body by subcutaneous injection or intravenous injection.
  • a treatment method for diabetic patients a treatment in which a minute amount of insulin is continuously infused into the body of the patient is performed.
  • a portable drug solution administration device that can be fixedly carried on the patient's body or clothes is used.
  • Patent Document 1 As a conventional chemical solution administration device, for example, there is one described in Patent Document 1.
  • the chemical solution administration device described in Patent Document 1 includes a chemical solution storage unit that stores a chemical solution and a piston that is driven in the chemical solution storage unit. And a chemical
  • the chemical solution storage unit is not pre-filled with the chemical solution. Therefore, when using the chemical solution administration device, the user needs to perform an operation of filling the chemical solution storage unit from a chemical solution container (for example, a vial) in which the chemical solution is separately stored.
  • a chemical solution container for example, a vial
  • a user first pours a drug solution from a drug solution container using a syringe. And there exists a method of puncturing the needle tube of a syringe in the filling port provided in the chemical
  • the chemical storage section and the chemical container are connected using an adapter.
  • the chemical solution storage unit and the chemical container are connected using an adapter.
  • the user determines whether or not the filling is completed by visually observing the chemical solution storage unit. Therefore, when the drug solution filled in the drug solution storage unit is a colorless and transparent drug solution such as insulin that is difficult to visually recognize, it is difficult to determine whether or not the filling operation of the drug solution into the drug solution storage unit is completed. Had a problem.
  • An object of the present invention is to provide a chemical solution filling device that can easily determine the completion of the filling of the chemical solution into the chemical solution storage unit even when the color of the chemical solution is difficult to see in consideration of the above problems.
  • the chemical solution filling apparatus of the present invention includes a housing, a mounting part, a suction side connection port, and a suction mechanism.
  • the mounting unit is provided in the housing, and is mounted with a chemical solution storage unit having a filling port into which the chemical solution is injected and a liquid feeding port for sending out the filled chemical solution.
  • the suction side connection port communicates with the liquid supply port.
  • the suction mechanism sucks the gas inside the chemical solution storage unit through the suction side connection port.
  • the suction mechanism includes a lever member, a suction side pusher, a syringe, and a notification mechanism.
  • the lever member is rotatably provided on the housing.
  • the suction side pusher is operated by a lever member.
  • the suction side pusher is slidably inserted into the syringe.
  • the notification mechanism notifies that the chemical solution storage unit is filled with the chemical solution based on the load applied to the lever member. And when the gas of a chemical
  • FIG. 1 is an exploded perspective view showing a chemical solution filling apparatus and a chemical solution filling unit according to an embodiment of the present invention. It is a front view which shows the chemical
  • FIG. 6A is an explanatory diagram illustrating a state before the lever member 48 is operated
  • FIG. FIG. 7A is a diagram illustrating the operation of the notification mechanism in a state where the filling of the chemical liquid in the chemical liquid filling apparatus according to the embodiment of the present invention has been completed.
  • FIG. 6A is an explanatory diagram illustrating a state before the lever member 48 is operated
  • FIG. FIG. 7A is a diagram illustrating the operation of the notification mechanism in a state where the filling of the chemical liquid in the chemical liquid filling apparatus according to the embodiment of the present invention has been completed.
  • FIG. 1 is a perspective view of the chemical liquid filling device of this example as viewed from the front
  • FIG. 2 is an exploded perspective view showing the chemical liquid filling device, the filling adapter, and the chemical liquid storage device of this example.
  • an outer case 61 of the chemical storage device 2 described later is shown transparent.
  • the chemical liquid filling apparatus 1 is an apparatus that fills the chemical liquid storage unit 62 of the chemical liquid storage device 2 with the chemical liquid.
  • a chemical solution storage device 2 and a filling adapter 3 constituting the chemical solution administration device are attached to the chemical solution filling apparatus 1.
  • the filling adapter 3 is attached to the chemical solution storage device 2 in advance.
  • the chemical solution storage unit 2 and the filling adapter 3 constitute a chemical solution filling unit 5.
  • a chemical solution filling set 10 is configured by the chemical solution filling device 1 and the chemical solution filling unit 5 attached to the chemical solution filling device 1.
  • a vial 4 showing an example of a chemical solution container is attached to the filling adapter 3.
  • the medicinal solution storage device 2 is combined with a drive unit having a power source, a driving mechanism for feeding medicinal solution, and the like to form a medicinal solution administration device.
  • the drug solution administration device is a portable drug solution administration device for continuously administering a drug solution into a patient's body, such as a patch-type insulin pump, tube-type insulin pump, and other portable drug solution administration devices. Widely applied.
  • FIG. 3 is a front view showing the chemical solution filling set 10.
  • FIG. 3 shows a state where the first case 16 in the chemical liquid filling device 1 is removed.
  • the chemical liquid filling apparatus 1 includes a casing 11 constituting an external appearance, a filling amount adjusting mechanism 12 provided in the casing 11, and a suction mechanism 13.
  • the casing 11 is formed in a substantially rectangular parallelepiped shape with a part cut away, and is formed so as to be gripped by a user.
  • the housing 11 has a first case 16 and a second case 17 that overlap each other.
  • the first case 16 has a substantially rectangular front part 16a, an upper surface part 16b that extends substantially vertically from one end in the longitudinal direction of the front part 16a, and a substantially vertical part that continues from the other longitudinal end of the front part 16a. And a mounting surface portion 16c facing the upper surface portion 16b.
  • the first case 16 includes a first side surface 16d that is substantially perpendicular to one end of the front portion 16a in the short direction, and a first side surface that is substantially perpendicular to the other side of the front portion 16a in the short direction. It has the 2nd side part 16e facing the part 16d.
  • medical solution filling apparatus 1 stands upright with the longitudinal direction of the housing
  • a pedestal portion 18 is provided that projects toward both sides in the short direction.
  • the pedestal portion 18 is formed with an insertion hole 22 opened in a substantially circular shape.
  • a mounting portion 21 is provided above the pedestal portion 18 in the front portion 16a.
  • the mounting portion 21 is formed from the front portion 16a to the upper surface portion 16b.
  • the mounting part 21 is dented from one surface of the front part 16a toward the width direction orthogonal to the longitudinal direction and the short direction of the front part 16a.
  • medical solution filling unit 5 is mounted
  • the main surface portion 21a that is parallel to one surface of the front portion 16a of the mounting portion 21 is formed with an opening portion 23 that is opened in a substantially square shape and a through hole 24.
  • a positioning groove 26 is provided on the side wall 21b on the second side surface portion 16e side of the mounting portion 21.
  • a rotation pin, a first bearing portion, and a second bearing portion are provided on one side in the longitudinal direction of the front portion 16a and on the other surface opposite to the exposed one surface.
  • a lever member 48 of the suction mechanism 13 described later is rotatably supported by the rotation pin.
  • a feed screw shaft 34 of a filling amount adjusting mechanism 12 (to be described later) is rotatably supported on the first bearing portion, and a guide member 37 of the filling amount adjusting mechanism 12 is swung on the second bearing portion.
  • a pin is rotatably supported.
  • a suction side connection hole 27 into which a second connection port 74 of the filling adapter 3 described later is inserted is provided in the upper surface portion 16b.
  • the suction side connection hole 27 is provided with a suction side connection port 55 of the suction mechanism 13 described later.
  • a lever member 48 of the suction mechanism 13 described later is disposed on the first side surface portion 16d.
  • the second case 17 is formed in a substantially rectangular flat plate shape and is arranged on the back side of the housing 11.
  • the second case 17 covers an opening formed by the upper surface portion 16b, the first side surface portion 16d, the second side surface portion 16e, and the placement surface portion 16c in the first case 16. Further, the other side of the second case 17 in the longitudinal direction protrudes toward both sides in the lateral direction, similarly to the front portion 16 a of the first case 16.
  • the filling amount adjusting mechanism 12 includes a feed screw shaft 34, an operation unit 35, a movable member 36, a guide member 37, and a hook member 38.
  • the feed screw shaft 34 is rotatably supported by a first bearing portion (not shown) provided in the first case 16.
  • the feed screw shaft 34 is provided with a thread groove extending spirally on the outer peripheral surface thereof.
  • the feed screw shaft 34 is arranged such that its axial direction is along the longitudinal direction of the housing 11.
  • An operation unit 35 is provided on the other side of the feed screw shaft 34 in the axial direction.
  • the operation unit 35 is formed in a substantially disk shape and is fixed to the feed screw shaft 34. A part of the operation unit 35 is exposed from an operation window (not shown) of the second case 17. Then, when the user rotates the operation unit 35, the feed screw shaft 34 rotates.
  • the guide member 37 is formed in a substantially rectangular flat plate shape.
  • a swing pin (not shown) is provided at one end of the guide member 37 in the longitudinal direction.
  • the swing pin of the guide member 37 is rotatably attached to a second bearing (not shown) provided in the first case 16. As a result, the guide member 37 rotates around the swing pin.
  • a bent piece 37 a is provided on the other side in the longitudinal direction of the guide member 37.
  • a release button 42 protrudes from one surface of the bent piece 37a. As shown in FIG. 2, the release button 42 is inserted through the insertion hole 22 of the first case 16.
  • a return spring (not shown) is disposed between the bent piece 37 a and the second case 17.
  • a guide groove (not shown) is formed between the swing pin of the guide member 37 and the bent piece 37a.
  • the guide groove is formed along the longitudinal direction of the guide member 37.
  • an engagement piece 43 is formed between the guide groove in the guide member 37 and the bent piece 37a.
  • the engagement piece 43 protrudes in the same direction as the release button 42. As shown in FIG. 2, the engagement piece 43 passes through the through hole 24 of the first case 16.
  • the movable member 36 is formed in a substantially flat plate shape, and an opening portion that is opened in a substantially rectangular shape is formed in the approximate center thereof.
  • a nut portion 44 is provided on one side of the movable member 36. The nut portion 44 engages with the feed screw shaft 34.
  • a hook member 38 is inserted into the opening of the movable member 36.
  • the hook member 38 has a sliding piece (not shown) that is slidably inserted into the guide groove of the guide member 37, and a hook piece 38a.
  • the hook piece 38 a protrudes in the same direction as the engagement piece 43.
  • the hook piece 38a is engaged with a nut piece 64c of the chemical solution storage device 2 described later.
  • the hook member 38 is attached to the guide member 37 through a sliding piece. Therefore, when the guide member 37 rotates, the hook member 38 moves together with the guide member 37.
  • the suction mechanism 13 includes a suction side connection port 55, a suction tube 46, a syringe 47, a lever member 48, a suction side pusher 49, a lever member 48, and a suction side pusher 49. And a notification mechanism 100 for connecting the two.
  • the suction side connection port 55 is disposed in the suction side connection hole 27 provided in the housing 11. As shown in FIG. 3, the suction side connection port 55 is connected to a suction tube 46 that is an example of a suction passage. One end of the suction tube 46 is connected to the suction side connection port 55, and the other end of the suction tube 46 is connected to the syringe 47.
  • a first check valve 51 is provided in the middle of the suction tube 46.
  • the first check valve 51 is opened only when the gas passing through the suction tube 46 goes from the suction side connection port 55 to the syringe 47, and is closed when the gas goes from the syringe 47 to the suction side connection port 55.
  • the syringe 47 is formed in a substantially cylindrical shape.
  • a second check valve 52 is provided at one end of the syringe 47 in the axial direction. The second check valve 52 is opened only when the gas is discharged from the syringe 47 to the outside of the apparatus, and is closed when the gas is sucked into the syringe 47 from the outside except the suction tube 46. Therefore, only the gas that passes through the suction tube 46 is fed into the syringe 47.
  • the suction side pusher 49 is inserted into the cylindrical hole of the syringe 47 so as to be slidable in the axial direction of the syringe 47.
  • the suction side pusher 49 adjusts the capacity in the syringe 47 freely.
  • the suction side pusher 49 is provided with a pressing spring 53.
  • the pressing spring 53 is interposed between the suction side pusher 49 and the second side surface portion 16 e of the first case 16. The pressing spring 53 urges the suction side pusher 49 toward one side in the axial direction of the syringe 47.
  • a lever member 48 is connected to the suction side pusher 49 via the notification mechanism 100.
  • a bearing hole 48 a is provided at one end of the lever member 48.
  • a rotation pin (not shown) provided in the first case 16 is passed through the bearing hole 48a.
  • the lever member 48 is rotatably supported by the first case 16 and the second case 17 around the rotation pin.
  • the notification mechanism 100 is rotatably attached to the other end portion of the lever member 48.
  • the notification mechanism 100 includes a first member 101, a second member 102, a first biasing spring 103, and a second biasing spring 104.
  • One end of the first member 101 is attached to the lever member 48 via a connection pin 101a.
  • the first member 101 is formed with a saw blade-like engagement portion 101b having a plurality of irregularities along the moving direction of the first member 101. And the engaging part 101b of the 1st member 101 is engaged with the 2nd member 102 so that a movement is possible.
  • the second member 102 is rotatably attached to the suction side pusher 49 via the connection pin 102a.
  • the second member 102 is formed with an engaged portion 102 b that engages with the engaging portion 101 b of the first member 101.
  • the engaged portion 102 b is formed in a saw blade shape having a plurality of irregularities along the moving direction of the first member 101.
  • the 2nd member 102 is supporting the 1st member 101 so that a movement to the direction which approaches and leaves
  • a first biasing spring 103 is interposed between the end of the first member 101 opposite to the connection pin 101a and the end of the second member 102 on the connection pin 102a side.
  • the first biasing spring 103 biases the first member 101 in a direction away from the end of the second member 102 on the connection pin 102a side.
  • the second biasing spring 104 is interposed between the first member 101 and the second member 102.
  • the second urging spring 104 is disposed at a position on the opposite side of the portion between the first member 101 and the second member 102 where the engaging portion 101b and the engaged portion 102b are engaged.
  • the second biasing spring 104 biases the engaging portion 101b of the first member 101 toward the engaged portion 102b.
  • the suction side pusher 49 moves together with the first member 101 and the second member 102 of the notification mechanism 100 to the other side in the axial direction of the syringe 47 against the biasing force of the pressing spring 53. (See FIGS. 5 and 6B). Thereby, the capacity
  • the suction side pusher 49 When the user stops the gripping operation of the lever member 48, the suction side pusher 49 is urged by the pressing spring 53 and inserted into the syringe 47.
  • the suction tube 46 is provided with a first check valve 51 that blocks air from the syringe 47 toward the suction side connection port 55. Therefore, the air in the syringe 47 is discharged to the outside through the second check valve 52. Further, the moving force of the suction side pusher 49 is transmitted to the lever member 48 via the notification mechanism 100, and the lever member 48 returns to the initial state shown in FIG.
  • the chemical storage device 2 includes an exterior case 61 having an open surface, a chemical storage unit 62 accommodated in the exterior case 61, a storage unit side connection port 63, and a pusher member 64. have.
  • the outer case 61 is formed in a container shape that is open on one side.
  • the exterior case 61 has a main surface portion 61a formed in a substantially rectangular shape, a side wall 61b surrounding the main surface portion 61a, and a recessed portion 61c that is recessed by one step from the main surface portion 61a.
  • the recessed portion 61c is provided with a substantially cylindrical storage portion side connecting tube 66.
  • Positioning protrusions 61d are provided on the side wall 61b of the outer case 61 (see FIG. 2). The positioning protrusion 61 d is inserted into the positioning groove 26 provided in the mounting portion 21 when the chemical solution filling unit 5 is attached to the chemical solution filling apparatus 1.
  • the chemical storage part 62 is formed in a substantially cylindrical shape, with one surface being closed and the other surface being open.
  • a filling port 62 a and a liquid feeding port 62 b are provided at the end of the chemical liquid storage unit 62 on the closing side.
  • a chemical solution is injected from the filling port 62a, and air or a chemical solution is sent out from the liquid supply port 62b.
  • the liquid feeding port 62b is disposed above the filling port 62a in the vertical direction.
  • a liquid supply tube 69 is connected to the liquid supply port 62b.
  • the storage unit side connection port 63 is connected to the end of the liquid supply tube 69 opposite to the liquid supply port 62b.
  • the storage unit side connection port 63 is disposed in the storage unit side connection cylinder 66 in the outer case 61.
  • the pusher member 64 is slidably inserted into the cylindrical hole of the chemical liquid storage unit 62.
  • the pusher member 64 includes a gasket 64a that moves while being in close contact with the inner peripheral surface of the chemical solution storage unit 62, a shaft portion 64b that is attached to the gasket 64a, and a nut piece 64c that is fixed to the shaft portion 64b. Have.
  • the nut piece 64c is provided on the opposite side of the shaft 64b from the gasket 64a. When the chemical storage device 2 and the drive unit are combined together, the nut piece 64c is engaged with the screw shaft of the drive mechanism provided in the drive unit.
  • the nut piece 64c engages with the hook piece 38a of the filling amount adjusting mechanism 12 when the chemical solution filling unit 5 is attached to the chemical solution filling apparatus 1.
  • the filling adapter 3 includes a main body portion 71, a support portion 72, a first connection port 73, a second connection port 74, a liquid supply needle tube 75 and a ventilation needle tube 76 held in the main body portion 71, and a ventilation filter. 77. Further, the filling adapter 3 has a protection mechanism 78 provided in the main body 71.
  • the main body 71 is formed in a substantially rectangular parallelepiped shape.
  • a support portion 72, a protection mechanism 78, a liquid feeding needle tube 75, and a ventilation needle tube 76 are disposed on one side in the longitudinal direction of the main body portion 71.
  • a first connection port 73 and a second connection port 74 are disposed on the other side of the main body 71 in the longitudinal direction.
  • the first connection port 73 and the second connection port 74 are formed in a substantially cylindrical shape.
  • the first connection port 73 is inserted into the storage unit side connection tube 66 of the chemical solution storage device 2 and connected to the storage unit side connection port 63.
  • the second connection port 74 is inserted into the suction side connection hole 27 of the chemical liquid filling apparatus 1 and connected to the suction side connection port 55.
  • the main body 71 is formed with a communication path 84 (see FIG. 4) that allows the first connection port 73 and the second connection port 74 to communicate with each other.
  • the communication path 84 is provided with a ventilation filter 77 (see FIGS. 4 and 5).
  • the ventilation filter 77 has a mechanism that allows only gas such as air to pass therethrough and prevents liquid from passing therethrough.
  • a needle tip is provided at one end of each of the liquid-feeding needle tube 75 and the ventilation needle tube 76.
  • One end of each of the liquid-feeding needle tube 75 and the ventilation needle tube 76 is punctured by a rubber plug that seals the opening of the vial 4 and penetrates the rubber plug.
  • a needle tip is also provided at the other end of the liquid feeding needle tube 75.
  • the other end of the liquid feeding needle tube 75 is pierced into the filling port 62a of the drug solution storage unit 62 and penetrates the filling port 62a.
  • the other end side of the liquid feeding needle tube 75 is bent in a substantially L shape.
  • the liquid feeding needle tube 75 and the ventilation needle tube 76 are held by the main body 71.
  • One end sides of the liquid-feeding needle tube 75 and the ventilation needle tube 76 protrude from one surface of the main body 71.
  • the other end side of the liquid feeding needle tube 75 protrudes from the other surface which is the surface opposite to the one surface of the main body 71. That is, the liquid feeding needle tube 75 is provided so as to penetrate the main body portion 71 in the vertical direction.
  • the other end of the ventilation needle tube 76 protrudes from the other surface of the main body 71, or the end surface thereof is located on the same plane as the other surface.
  • the other end of the ventilation needle tube 76 does not have to protrude from the other surface of the main body 71.
  • a ventilation hole communicating with the ventilation needle tube 76 may be provided in the main body 71.
  • a substantially cylindrical support portion 72 is provided on one side of the main body portion 71 in the longitudinal direction.
  • the opening of the support portion 72 is set to a size that allows the mouth portion of the vial 4 to be inserted.
  • One end side of the liquid feeding needle tube 75 and the ventilation needle tube 76 is disposed in the cylindrical hole of the support portion 72. That is, the support portion 72 is formed in a cylindrical shape that covers the periphery of the liquid feeding needle tube 75 and the ventilation needle tube 76, and is spaced apart from the needle tip on one side of the liquid feeding needle tube 75 and the ventilation needle tube 76 in the radial direction. Is provided. Thereby, it is possible to prevent the user from accidentally puncturing the needle tips on one end side of the liquid-feeding needle tube 75 and the ventilation needle tube 76.
  • the protection mechanism 78 (see FIGS. 1 and 2) is provided in the main body 71 and is rotatably disposed in the vicinity of the other end of the liquid feeding needle tube 75 in the main body 71.
  • the protection mechanism 78 rotates to cover the other end side of the liquid feeding needle tube 75. Thereby, the needle tip on the other end side of the liquid feeding needle tube 75 after the filling operation is completed can be covered, and the used filling adapter 3 can be brought into a safe state.
  • FIG. 4 is an explanatory view schematically showing the filling operation of the chemical solution.
  • FIG. 5 is a front view of the chemical solution filling set 10 illustrating the operation of filling the chemical solution storage unit 62 of the chemical solution storage device 2 with the chemical solution.
  • 6 and 7 are explanatory diagrams showing the operation of the notification mechanism 100 during the filling operation.
  • the user stands the chemical solution filling apparatus 1 on a desk or a stand so that the opening on the upper surface portion 16 b side of the mounting portion 21 faces upward.
  • the chemical solution filling device 1 is provided with a pedestal portion 18 projecting on both sides of the first side surface portion 16 d and the second side surface portion 16 e below the housing 11. Thereby, the chemical
  • the operation unit 35 of the chemical solution filling apparatus 1 is operated to set a display piece (not shown) at a predetermined scale position.
  • the setting of the filling amount adjusting mechanism 12 may be performed before the chemical liquid filling device 1 is placed on a desk or a table, or may be performed after the chemical liquid filling unit 5 is attached to the chemical liquid filling device 1.
  • the filling adapter 3 is attached to the chemical solution storage device 2 in advance.
  • the other end side of the liquid feeding needle tube 75 in the filling adapter 3 passes through the filling port 62 a of the chemical solution storage unit 62.
  • the first connection port 73 is inserted into the storage unit side connection tube 66 of the chemical solution storage device 2.
  • medical solution storage tool 2 the liquid supply tube 69, the storage part side connection port 63, and the 1st connection port 73 of the filling adapter 3 are connected.
  • the chemical solution filling unit 5 is attached to the chemical solution filling apparatus 1. Specifically, the protrusion 61 d of the chemical solution storage device 2 is inserted into the positioning groove 26 of the mounting portion 21, and the chemical solution storage device 2 is mounted on the mounting portion 21. Further, the second connection port 74 of the filling adapter 3 is inserted into the suction side connection hole 27 of the chemical solution filling apparatus 1. As a result, the second connection port 74 and the suction side connection port 55 communicate with each other.
  • a suction passage 95 is constituted by the liquid feeding tube 69, the communication passage 84 and the suction tube 46.
  • the hook piece 38a of the filling amount adjusting mechanism 12 is engaged with the nut piece 64c of the chemical liquid storage device 2, and the insertion position of the pusher member 64 with respect to the chemical liquid storage section 62 is held at a predetermined position.
  • the position of the gasket 64 a of the pusher member 64 in the chemical solution storage unit 62 is maintained, and the capacity in the chemical solution storage unit 62 can be maintained at a set amount.
  • the position of the hook piece 38a engaged with the nut piece 64c can be changed by operating the operation section 35, and the capacity of the chemical liquid storage section 62 can be increased. Can be easily changed.
  • the vial 4 having a chemical solution is attached to the support portion 72 of the filling adapter 3.
  • one end side of the liquid feeding needle tube 75 and the ventilation needle tube 76 of the filling adapter 3 penetrates the rubber stopper of the vial bottle 4, and the liquid feeding needle tube 75, the ventilation needle tube 76 and the internal space of the vial bottle 4 are formed.
  • the other end of the liquid feeding needle tube 75 passes through the filling port 62 a of the chemical liquid storage unit 62. Therefore, as shown in FIG. 4A, the internal space of the vial 4 and the internal space of the drug solution storage unit 62 communicate with each other via the liquid supply needle tube 75.
  • the vial 4 may be attached to the filling adapter 3 before the chemical solution filling unit 5 is attached to the chemical solution filling apparatus 1.
  • the user grasps the casing 11, grasps the lever member 48, and rotates the lever member 48.
  • FIGS. 6A and 6B when the pressure in the suction tube 46 and the syringe 47 is equal to the atmospheric pressure, the load applied to the lever member 48 is light.
  • the second member 102 is at the reference position shown in FIG. 6A. It moves from P to the other side in the axial direction of the syringe 47 together with the first member 101. Therefore, the suction side pusher 49 connected to the second member 102 via the connection pin 102a also moves, and the capacity in the syringe 47 increases.
  • the syringe 47 is provided with a second check valve 52 that opens only when the gas is discharged from the syringe 47 to the outside and closes when the gas is sucked into the syringe 47 from the outside. . Therefore, the pressure in the syringe 47 temporarily decreases. And since the pressure in the syringe 47 becomes a negative pressure, the suction mechanism 13 sucks air from the suction tube 46 side.
  • the air in the chemical solution storage unit 62 is sucked into the syringe 47 through the suction passage 95.
  • the inside of the chemical solution storage unit 62 has a negative pressure.
  • the pressure in the syringe 47 returns to the initial value, that is, the atmospheric pressure.
  • the chemical solution M1 is injected from the vial bottle 4 into the chemical solution storage unit 62 via the liquid supply needle tube 75 and the filling port 62a.
  • external air is fed into the vial 4 via the aeration needle tube 76. In this way, the user can easily inject the chemical M1 into the chemical storage part 62 by gripping the lever member 48.
  • the suction side pusher 49 When the user stops the gripping operation of the lever member 48, the suction side pusher 49 is urged by the pressing spring 53 and inserted into the syringe 47.
  • the suction tube 46 is provided with a first check valve 51 that blocks air from the syringe 47 toward the suction side connection port 55. Further, as described above, the syringe 47 is opened only when the gas is discharged from the syringe 47 to the outside of the apparatus, and is closed when the gas is sucked into the syringe 47 from the outside.
  • a valve 52 is provided. Therefore, the air in the syringe 47 is discharged to the outside via the second check valve 52 instead of the suction tube 46 side. Further, the moving force of the suction side pusher 49 is transmitted to the lever member 48 via the notification mechanism 100, and the lever member 48 returns to the initial state shown in FIG.
  • the user repeats the gripping operation of the lever member 48.
  • the air in the drug solution storage unit 62 is sucked by the suction mechanism 13 of the drug solution filling apparatus 1 to be negative pressure, and the drug solution M1 is injected into the drug solution storage unit 62 from the vial 4.
  • the chemical solution M1 is filled up to the liquid feeding tube 69 as shown in FIG. 4B.
  • the suction passage 95 is provided with a ventilation filter 77 that allows only a gas such as air to pass therethrough and does not allow liquid to pass therethrough. Then, the chemical liquid M1 is filled up to the chemical liquid storage section 62 and the ventilation filter 77 in the suction passage 95.
  • the first member 101 is urged by the first urging spring 103 and returns to the initial position shown in FIGS. 3 and 7A.
  • the present invention is not limited to this.
  • a detection unit that detects the disengagement between the engagement portion 101b and the engaged portion 102b is provided and the detection portion detects the release of the engagement between the engagement portion 101b and the engaged portion 102b. You may make it operate
  • the liquid feeding port 62b through which air is sucked in the chemical liquid storage unit 62 is disposed above the filling port 62a into which the chemical liquid M1 is injected in the vertical direction. Furthermore, the air in the chemical solution storage unit 62 is sucked by the suction mechanism 13 of the chemical solution filling apparatus 1, so that the air in the chemical solution storage unit 62 can be discharged without leaving the liquid feeding port 62 b. As a result, it is possible to omit the operation of operating the pusher member 64 provided in the chemical solution storage device 2 after the chemical solution filling operation to remove the remaining air from the chemical solution storage unit 62.
  • the capacity of the chemical solution storage unit 62 does not change, and an appropriate amount can be filled in the chemical solution storage unit 62, and the chemical solution M1 generated when the air is vented is obtained. Emissions can be eliminated.
  • the filling operation can be performed in the state where the liquid feeding port 62b and the filling port 62a are arranged above the gasket 64a of the pusher member 64 in the vertical direction by the chemical filling device 1.
  • the chemical solution filling unit 5 is removed from the chemical solution filling apparatus 1. Specifically, the release button 42 is pressed. As a result, the guide member 37 rotates around a swing pin (not shown). As a result, the engagement between the engagement piece 43 and the outer case 61 is released, and the engagement between the hook piece 38a and the nut piece 64c is released.
  • the chemical solution filling unit 5 is pulled upward.
  • the second connection port 74 is pulled out from the suction side connection hole 27, and the drug solution storage device 2 is removed from the mounting portion 21.
  • external air enters the syringe 47 from the suction side connection port 55 and the suction tube 46, and the pressure of the syringe 47 returns to atmospheric pressure.
  • the chemical solution filling operation into the chemical solution storage unit 62 is completed.
  • the vial 4 may be removed from the filling adapter 3 before removing the chemical filling unit 5 from the chemical filling device 1.
  • FIG. 8 is an explanatory diagram showing a modified example of the notification mechanism
  • FIG. 9 is a block diagram showing a configuration of a control system in the modified example of the notification mechanism.
  • the link member 50 is provided with a load detection unit 201 that constitutes a notification mechanism.
  • the load detection unit 201 is a strain gauge that detects strain of the link member 50, for example. As described above, when the chemical solution M1 is filled in the chemical solution storage unit 62, the load applied to the lever member 48 increases. And the load added to the link member 50 which connects the lever member 48 and the suction side pusher 49 also becomes large, and the link member 50 is slightly distorted.
  • the load detection unit 201 detects strain generated in the link member 50.
  • the notification mechanism includes a load detection unit 201, a control unit 202 connected to the load detection unit 201, and a notification unit 203.
  • the load detection unit 201 transmits the detected strain information of the link member 50 to the control unit 202.
  • the control unit 202 calculates the load applied to the lever member 48 based on the strain information sent from the load detection unit 201.
  • a notification unit 203 is connected to the control unit 202.
  • reporting part 203 has a structure which can alert
  • the control unit 202 determines whether or not the chemical solution storage unit 62 is filled with the chemical solution M1 based on the calculated load information applied to the lever member 48. When the control unit 202 determines that the chemical solution storage unit 62 is filled with the chemical solution M1, the control unit 202 activates the notification unit 203. Thereby, it can alert

Abstract

L'invention concerne un dispositif de remplissage de médicaments liquides qui est pourvu d'un mécanisme d'aspiration qui aspire un gaz se trouvant à l'intérieur d'une partie de stockage de médicament liquide à travers un orifice de raccordement côté aspiration. Le mécanisme d'aspiration possède un élément de type levier, un piston côté aspiration, une seringue et un mécanisme de notification. Sur la base de la contrainte appliquée sur l'élément de type levier, le mécanisme de notification fournit une notification indiquant que la partie de stockage de médicament liquide a été remplie de médicament liquide.
PCT/JP2015/073492 2014-09-25 2015-08-21 Dispositif de remplissage de médicaments liquides WO2016047325A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2016550037A JP6625994B2 (ja) 2014-09-25 2015-08-21 薬液充填装置

Applications Claiming Priority (2)

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JP2014194852 2014-09-25
JP2014-194852 2014-09-25

Publications (1)

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WO2016047325A1 true WO2016047325A1 (fr) 2016-03-31

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WO (1) WO2016047325A1 (fr)

Citations (3)

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JP2010501283A (ja) * 2006-08-23 2010-01-21 メドトロニック ミニメド インコーポレイテッド 貯蔵容器内のプランジャを駆動するための駆動デバイスを用いる注入媒体送達デバイスおよび方法
JP2012196342A (ja) * 2011-03-22 2012-10-18 Terumo Corp 薬液投与装置及び薬液投与装置の薬液充填方法
JP2014030576A (ja) * 2012-08-03 2014-02-20 Panasonic Corp 薬剤移注方法および薬剤移注装置

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JP2004329685A (ja) * 2003-05-09 2004-11-25 Terumo Corp 薬液充填装置及び薬液充填システム
JP2010082337A (ja) * 2008-10-01 2010-04-15 Hitachi Medical Corp 超音波診断装置
US8141601B2 (en) * 2008-10-02 2012-03-27 Roche Diagnostics Operations, Inc. Manual filling aid with push button fill
EP2319477B1 (fr) * 2009-11-06 2011-12-28 F. Hoffmann-La Roche AG Dispositif de remplissage d'un conteneur de réservoir flexible dans une chambre à pression négative
JP2013070713A (ja) * 2011-09-26 2013-04-22 Terumo Corp 薬液投与装置

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
JP2010501283A (ja) * 2006-08-23 2010-01-21 メドトロニック ミニメド インコーポレイテッド 貯蔵容器内のプランジャを駆動するための駆動デバイスを用いる注入媒体送達デバイスおよび方法
JP2012196342A (ja) * 2011-03-22 2012-10-18 Terumo Corp 薬液投与装置及び薬液投与装置の薬液充填方法
JP2014030576A (ja) * 2012-08-03 2014-02-20 Panasonic Corp 薬剤移注方法および薬剤移注装置

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JP6625994B2 (ja) 2019-12-25

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