WO2016031222A1 - 測定装置及び測定方法 - Google Patents

測定装置及び測定方法 Download PDF

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Publication number
WO2016031222A1
WO2016031222A1 PCT/JP2015/004230 JP2015004230W WO2016031222A1 WO 2016031222 A1 WO2016031222 A1 WO 2016031222A1 JP 2015004230 W JP2015004230 W JP 2015004230W WO 2016031222 A1 WO2016031222 A1 WO 2016031222A1
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Prior art keywords
unit
pressure
information
measurement
measurement accuracy
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PCT/JP2015/004230
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English (en)
French (fr)
Japanese (ja)
Inventor
欣也 杉本
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京セラ株式会社
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Priority to US15/503,170 priority Critical patent/US20170224235A1/en
Publication of WO2016031222A1 publication Critical patent/WO2016031222A1/ja

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/026—Measuring blood flow
    • A61B5/0261—Measuring blood flow using optical means, e.g. infrared light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/026—Measuring blood flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6843—Monitoring or controlling sensor contact pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6887—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient mounted on external non-worn devices, e.g. non-medical devices
    • A61B5/6898—Portable consumer electronic devices, e.g. music players, telephones, tablet computers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7221—Determining signal validity, reliability or quality
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7271—Specific aspects of physiological measurement analysis
    • A61B5/7275—Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/02—Operational features
    • A61B2560/0242—Operational features adapted to measure environmental factors, e.g. temperature, pollution
    • A61B2560/0247—Operational features adapted to measure environmental factors, e.g. temperature, pollution for compensation or correction of the measured physiological value
    • A61B2560/0257—Operational features adapted to measure environmental factors, e.g. temperature, pollution for compensation or correction of the measured physiological value using atmospheric pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0247—Pressure sensors

Definitions

  • the present invention relates to a measuring apparatus and a measuring method.
  • a measuring device that acquires biological output information from a test site such as a fingertip of a subject (user) and measures the biological information is known.
  • a blood flow measuring device that measures blood flow as biological information irradiates a fingertip with a laser beam and measures blood flow based on scattered light from blood flow of capillaries at the fingertip (see, for example, Patent Document 1). ).
  • the measurement accuracy of biological information depends on the state of capillaries at the site to be examined, but the state of capillaries changes depending on the contact state of the site to be tested with the measurement device.
  • the state of capillaries changes with aging (see, for example, Non-Patent Documents 1 to 3), but the inner diameter of capillaries is approximately 5 ⁇ m to 10 ⁇ m, with an average of 7 ⁇ m. It is said that it is a grade (for example, refer nonpatent literature 4).
  • An object of the present invention made in view of such circumstances is to provide a measuring apparatus and a measuring method capable of improving convenience.
  • a measuring apparatus provides: A measuring device for measuring biological information by bringing a test site into contact with a contact part, A biosensor for obtaining biometric output from the test site; A control unit for measuring biological information based on the biological measurement output; A calculation unit for calculating information on measurement accuracy of the biological information; An information output unit configured to output information related to the biological information and the measurement accuracy.
  • a pressure detection unit for detecting a contact pressure of the test site in the contact unit;
  • a pressure measuring unit for measuring the ambient pressure,
  • the calculation unit may calculate information on the measurement accuracy based on the contact pressure and the ambient atmospheric pressure.
  • the calculation unit may calculate information on the measurement accuracy when the contact pressure is equal to or higher than a predetermined pressure.
  • the biological information includes information related to blood flow
  • the calculation unit may calculate information on the measurement accuracy according to the following equation (1).
  • r I denotes the inside diameter of the vessel at normal times in the measurement site
  • u p represents the displacement of the luminal diameter due to the influence of the blood flow
  • u s denotes the displacement of the luminal diameter due to the influence of the contact pressure .
  • the calculation unit may determine the measurement accuracy to be 1 when the absolute value of u p is larger than the absolute value of u s in the equation (1).
  • the present invention can be realized as a method substantially corresponding to the measurement apparatus described above, and these are also included in the scope of the present invention.
  • the measuring method is: In measuring biological information by bringing the test site into contact with the contact part, Obtaining a biometric output from the test site by a biosensor; Measuring biological information based on the biological measurement output by the control unit; Calculating information related to the measurement accuracy of the biological information by the calculation unit; Outputting the biological information and information on the measurement accuracy to an information output unit.
  • FIG. 1 is a functional block diagram showing a schematic configuration of a measuring apparatus according to an embodiment of the present invention.
  • the measurement device 10 includes a pressure detection unit 11, an atmospheric pressure measurement unit 12, a biosensor 13, a contact unit 14, a control unit 15, a notification unit 16, a storage unit 17, a display unit 18, and an input unit 19. And an arithmetic unit 20.
  • the measuring device 10 measures biological information at a test site that contacts the contact portion 14.
  • FIG. 2 is a diagram illustrating an example of a usage state of the measurement device 10, and is a diagram illustrating a state where a user presses a finger of a hand that is a test site against the measurement device 10.
  • the measurement apparatus 10 measures biological information in a state where the finger is pressed against the contact portion 14 as shown in FIG.
  • the biological information can be any biological information that can be measured using the biological sensor 13.
  • the measurement device 10 will be described below as an example of measuring the blood flow of a subject, which is information related to blood flow.
  • the pressure detection unit 11 detects a contact pressure acting on the contact unit 14.
  • the pressure detection unit 11 is configured by, for example, a piezoelectric element.
  • the pressure detection unit 11 is connected to the control unit 15 and transmits the detected pressure to the control unit 15 as a pressure signal. Therefore, when the test site is in contact with the contact part 14, the pressure detection unit 11 detects the pressure acting on the contact unit 14 from the test site, and transmits the detected pressure to the control unit 15 as a pressure signal. .
  • the atmospheric pressure measuring unit 12 measures the atmospheric pressure around the measuring device 10.
  • the atmospheric pressure measurement unit 12 is configured by a known barometer such as an aneroid barometer, a Bourdon tube barometer, or an electric barometer.
  • the atmospheric pressure measurement unit 12 is connected to the control unit 15 and transmits the measured atmospheric pressure as a signal to the control unit 15.
  • the atmospheric pressure measured by the atmospheric pressure measurement unit 12 is used to calculate the measurement accuracy of biological information, as will be described later.
  • the biological sensor 13 acquires a biological measurement output from the site to be examined.
  • the biological sensor 13 includes a light source 21 and a light receiving unit 22.
  • the light source 21 emits laser light based on the control of the control unit 15.
  • the light source 21 irradiates, for example, a laser beam having a wavelength capable of detecting a predetermined component contained in blood as measurement light, and is configured by, for example, an LD (Laser Diode: Laser Diode).
  • LD Laser Diode: Laser Diode
  • the light receiving unit 22 receives the scattered light of the measurement light from the test site as a biometric measurement output.
  • the light receiving unit 22 is configured by, for example, a PD (photodiode: Photo Diode).
  • the biological sensor 13 transmits a photoelectric conversion signal of scattered light received by the light receiving unit 22 to the control unit 15.
  • the contact unit 14 is a part that contacts a test site such as a finger in order for the subject to measure biological information.
  • the contact part 14 is comprised by the plate-shaped member, for example.
  • the contact portion 14 is configured by a member that is transparent at least with respect to the measurement light from the light source 21 and the scattered light from the region to be examined.
  • the control unit 15 is a processor that controls and manages the entire measurement apparatus 10 including each functional block of the measurement apparatus 10.
  • the control unit 15 includes a processor such as a CPU (Central Processing Unit) that executes a program that defines a control procedure, and the program is stored in, for example, the storage unit 17 or an external storage medium.
  • a processor such as a CPU (Central Processing Unit) that executes a program that defines a control procedure, and the program is stored in, for example, the storage unit 17 or an external storage medium.
  • a CPU Central Processing Unit
  • the control unit 15 controls the emission of laser light from the light source 21.
  • the control unit 15 operates from the light source 21 when the pressure detection unit 11 detects the contact pressure at the contact unit 14 after the subject operates the measurement device 10 to make the biological information measurable.
  • a laser beam is emitted.
  • Acquisition of the biometric output by the biosensor 13 is started by the emission of the laser light.
  • the control unit 15 determines whether or not acquisition of the biometric output by the biosensor 13 is completed after the biosensor 13 starts acquiring the biometric output by laser light emission.
  • the control unit 15 stops the output of the laser light from the light source 21.
  • control unit 15 may determine that the acquisition of the biometric output has ended after a predetermined time has elapsed since the biosensor 13 started acquiring the biometric output. In addition, for example, the control unit 15 may determine that the acquisition of the biometric output is completed when the biometric sensor 13 acquires a sufficient biometric output for measuring the biometric information. In this way, the control unit 15 controls the acquisition of the biological measurement output in the biological sensor 13.
  • the control unit 15 acquires a pressure signal from the pressure detection unit 11. And the control part 15 judges whether the contact pressure of the test site
  • the predetermined pressure is, for example, pressure at which information on the measurement accuracy calculated based on a calculation algorithm used to derive the measurement accuracy described later can serve as the measurement accuracy.
  • the predetermined pressure is stored in the storage unit 17 in advance. Is done.
  • the control unit 15 determines that the contact pressure of the test site in the contact unit 14 is equal to or higher than a predetermined pressure
  • the control unit 15 causes the calculation unit 20 to calculate measurement accuracy. That is, the calculation unit 20 calculates the measurement accuracy of the biological information using the calculation algorithm based on the control of the control unit 15.
  • the computing unit 20 calculates, for example, the measurement accuracy with the passage of time of the biological information being measured.
  • the calculating part 20 may calculate the measurement accuracy in the whole time which measured biometric information as a numerical value. A specific calculation algorithm will be described later.
  • the calculation unit 20 is described as an independent function unit different from the control unit 15, but the function of the calculation unit 20 may be included in the control unit 15. In this case, the control unit 15 calculates the measurement accuracy.
  • the control unit 15 determines that the contact pressure of the test site in the contact unit 14 is less than a predetermined pressure, the control unit 15 notifies the information about the contact pressure from the notification unit 16.
  • the notification of the information regarding the contact pressure is, for example, a notification that notifies the subject that the contact pressure is less than a predetermined pressure.
  • the notification of the information regarding the contact pressure may be a notification instructing to increase the contact pressure, for example.
  • reporting part 16 can alert
  • the notification unit 16 performs notification by a visual method, for example, the notification unit 16 performs notification by displaying an image or a character on a display device such as the display unit 18.
  • reporting part 16 may alert
  • the notification unit 16 performs notification by outputting an alarm sound, a voice guide, or the like as a sound generating device such as a speaker.
  • the notification performed by the notification unit 16 is not limited to a visual or auditory method, and may be any method that can be recognized by the subject.
  • Control part 15 will generate living body information based on living body information output (output of light sensing part 22), if acquisition of living body information output in living body sensor 13 is completed.
  • the control unit 15 is described as generating biological information, but the biological information may be generated by an independent functional unit different from the control unit 15.
  • the control unit 15 When measuring the blood flow, the control unit 15 irradiates the living tissue (test site) with laser light from the light source 21 and receives light scattered from the living tissue by the light receiving unit 22. And the control part 15 calculates a blood flow rate based on the output regarding the received scattered light.
  • the control unit 15 detects a beat signal (also referred to as a beat signal) generated by light interference between scattered light from a stationary tissue and scattered light from a moving blood cell.
  • This beat signal represents the intensity as a function of time.
  • the control part 15 makes this beat signal the power spectrum which represented power as a function of frequency.
  • the Doppler shift frequency is proportional to the blood cell velocity, and the power corresponds to the amount of blood cells.
  • the control part 15 calculates
  • FIG. 3 is a diagram illustrating an example of display of measurement results and measurement accuracy.
  • the control unit 15 displays changes in blood flow volume and measurement accuracy over time as measurement results.
  • the measurement accuracy is indicated by a solid line
  • the blood flow is indicated by a broken line.
  • control unit 15 displays the biological information and displays that the measurement accuracy of the displayed measurement result is extremely low. Also good.
  • the central maxima are lower than the other maxima.
  • the measurement accuracy is temporarily lowered. This is because the contact pressure was suitable for measuring the blood flow before and after the time when the central maximum was measured, whereas at the time when the central maximum was measured, for example, the contact pressure temporarily This indicates that the blood flow rate could not be properly measured due to the increase or decrease.
  • the storage unit 17 can be composed of a semiconductor memory, a magnetic memory, or the like, and stores various information, a program for operating the measuring apparatus 10, and the like, and also functions as a work memory.
  • the storage unit 17 may store the blood flow measured by the measurement device 10 in association with the measurement accuracy.
  • the storage unit 17 stores various information used by the calculation unit 20 to calculate measurement accuracy.
  • the storage unit 17 stores a predetermined pressure that is a criterion for determining whether to calculate the measurement accuracy using a calculation algorithm.
  • the storage unit 17 also stores information related to the subject that is necessary for the calculation unit 20 to calculate the measurement accuracy.
  • the information regarding the subject is, for example, the gender, age, height, normal blood pressure, and the like of the subject, and the information is input from the input unit 19 by the subject, for example.
  • the normal blood pressure is, for example, a blood pressure measured in advance by a subject using a known blood pressure monitor.
  • the storage unit 17 further stores information (data) necessary for the control unit 15 to use in the calculation algorithm together with the calculation algorithm used by the calculation unit 20 to calculate the measurement accuracy.
  • Information necessary for the control unit 15 to use in the calculation algorithm is, for example, data indicating the relationship between the standard inner diameter and outer diameter of the blood vessel with respect to age. About the change of the blood vessel by aging, it describes in the nonpatent literature 1 thru
  • stores in this Embodiment is not restricted to the data which show the relationship between age and the standard internal diameter and external diameter of a blood vessel.
  • Other examples of information stored in the storage unit 17 will be described in the description of the calculation algorithm executed by the calculation unit 20 described later.
  • the calculation unit 20 executes a calculation algorithm with reference to the data stored in the storage unit 17 and calculates the measurement accuracy of the biological information.
  • the display unit 18 is a display device such as a liquid crystal display, an organic EL display, or an inorganic EL display.
  • the display unit 18 displays, for example, the measurement result of the biological information by the measurement device 10.
  • the display unit 18 can also function as the notification unit 16 by notifying the subject of information related to the inclination of the measurement apparatus 10.
  • the input unit 19 receives an operation input from the subject, and includes an operation button (operation key), for example.
  • the input unit 19 may be configured by a touch panel, and the input unit 19 that receives an operation input from the subject may be displayed on a part of the display unit 18 to accept a touch operation input by the subject.
  • the subject can activate a dedicated application for measuring biological information in an electronic device such as a mobile phone in which the measurement device 10 is incorporated.
  • the computing unit 20 calculates the measurement accuracy based on, for example, the change rate of the blood vessel inner diameter. Specifically, the calculation unit 20 calculates the measurement accuracy using the above-described equation (1).
  • r I is the inner diameter of the blood vessel in normal times.
  • the inner diameter r I of the blood vessel in the normal condition is, for example, based on the gender and age input by the subject, and the control unit 15 stores data related to the standard blood vessel inner diameter for each sex and age stored in the storage unit 17. To determine.
  • the inner diameter r I of this blood vessel is about 5 ⁇ m to 10 ⁇ m, and is about 7 ⁇ m on average.
  • u p is the displacement of the inner diameter of the blood vessel due to the influence of the blood flow inside the blood vessel
  • u s is the displacement of the inner diameter of the blood vessel due to the influence of the contact pressure of the site to be examined brought into contact with the contact portion 14.
  • the displacement u p of the blood vessel inner diameter due to the influence of the blood flow and the displacement u s of the blood vessel inner diameter due to the influence of the contact pressure are calculated by the calculation unit 20 using a predetermined calculation algorithm.
  • the calculation algorithm in the present embodiment assuming that the blood vessel at the site to be examined is an ideal cylinder having elasticity, the displacement of the blood vessel inner diameter due to the user's pressing is estimated, and the change in the blood vessel inner diameter is calculated.
  • the calculation algorithm is not limited to that disclosed in this specification, and any algorithm that can estimate the displacement of the blood vessel inner diameter can be used.
  • the inner diameter r I vessels, the blood flow inside the blood vessel, (in this embodiment, the contact pressure) the pressure from the outside changes under the influence of the. That is, the blood vessel receives a pressure for expanding the inner diameter r I due to the blood flow inside the blood vessel, while receiving a pressure for contracting the inner diameter r I due to the contact pressure.
  • stress is generated in the radial direction and circumferential direction of the blood vessel, but no stress is generated in the length direction. It should be noted that in FIG. 4 to FIG. 8 referred to in the following description, minute elements are displayed in an enlarged manner for convenience of description.
  • the arrow displayed in relation to a microelement is used, for example, to indicate the direction of each element indicated by the arrow. Therefore, it should be noted that for these arrows, for example, the starting point of the arrow in the drawing is not necessarily the point where the element indicated by the arrow acts.
  • FIG. 4 is a schematic view of a cross section of a blood vessel.
  • the pressure due to the blood flow applied to the fan-shaped minute element in the blood vessel wall in the radial direction of the blood vessel will be described.
  • An axis in the same direction as the radial direction r in the microelement is defined as an X axis
  • an axis (tangential axis) orthogonal to the X axis is defined as a Y axis.
  • FIG. 5 is a diagram showing the pressure applied to the microelement in the blood vessel wall.
  • the central angle formed by the fan-shaped microelement is ⁇
  • the radial pressure (r direction) to the microelement in the blood vessel wall Is ⁇ r .
  • the pressure applied in the outer diameter direction of the microelement shown in FIG. 5A is expressed as shown in Expression (2).
  • the expression (4) is established based on the expressions (2) and (3). .
  • the radial component sigma X circumferential stress sigma t is the circumferential stress sigma t, because it is orthogonally projected in a radial direction (X-axis), a circle
  • the radial component ⁇ X of the circumferential stress ⁇ t is expressed as in Equation (5).
  • Equation (7) is obtained.
  • FIG. 7 is a diagram showing the displacement of one point in the blood vessel wall due to the influence of pressure caused by blood flow.
  • the blood vessel is an ideal cylinder having elasticity
  • the circumference of the blood vessel wall having the radius ⁇ uniformly expands and contracts.
  • Formula (15) is obtained by substituting Formula (13) and Formula (14) into Formula (7) and calculating.
  • equation (17) is obtained with c 1 and c 2 as integration constants.
  • integral constants c 1 and c 2 are obtained from the boundary conditions.
  • the inner radius of the blood vessel is r 1 and the outer radius is r 2 .
  • P is obtained by adding the hydrostatic pressure to the intravascular pressure due to blood flow.
  • the atmospheric pressure is P 0
  • the density of blood is ⁇
  • the acceleration of gravity is g
  • the displacement of the height of the test site from the heart is h
  • P is expressed by Expression (21).
  • the atmospheric pressure P 0 is the atmospheric pressure around the measuring apparatus 10 measured by the atmospheric pressure measurement unit 12.
  • the blood density ⁇ is determined based on, for example, the gender inputted by the subject with reference to the blood density for each gender stored in the storage unit 17.
  • the height displacement h from the heart of the test site is based on, for example, the height input by the subject, and the calculation unit 20 uses the standard heart height and living body for each height stored in the storage unit 17. The determination is made with reference to the data of the height relationship with the position of the test site in the information measurement posture.
  • FIG. 8 is a schematic diagram showing a state in which the test site is in contact with the contact portion 14, that is, a state in which the subject is measuring biological information.
  • the blood vessel receives pressure applied to the test site from the contact unit 14 in accordance with the contact pressure of the test site that contacts the contact unit 14. This pressure causes the blood vessels to contract.
  • the displacement u of the minute element of the blood vessel wall due to the blood vessel contraction can be calculated in the same manner as in equations (2) to (16), and is expressed as equation (17).
  • the inner diameter r I vessels since changes under the blood flow inside the blood vessel, the effect of the contact pressure, the inner diameter r I change is represented by u p + u s.
  • the computing unit 20 calculates the measurement accuracy by calculating Expression (1) using the displacement of the inner diameter obtained in this way.
  • the calculating part 20 is good also considering the maximum value of the measurement precision by Formula (1) as 1. That is, in the equation (1), when u p + u s is a positive number, the calculation result of the equation (1) is larger than 1. In this case, the calculation unit 20 determines the measurement accuracy as 1. Also good.
  • the u p and u s referring to formula (27) and (34), the sign of u p whereas some of positive, the sign of u s is negative. That is, u p + u s is a positive number when the absolute value of u p is larger than the absolute value of u s . Therefore, the arithmetic unit 20, the absolute value of u p is greater than the absolute value of u s, the measurement accuracy may be determined to one.
  • control unit 15 starts the flow of FIG. 10 when the subject operates the measuring device 10 and the measuring device 10 is ready to measure biological information.
  • the control unit 15 causes the light source 21 to emit laser light when the pressure detection unit 11 detects the contact pressure at the contact unit 14 (step S101). With the emission of the laser light, the control unit 15 starts to acquire the biological measurement output in the biological sensor 13.
  • control unit 15 acquires a pressure signal indicating information related to the contact pressure at the contact unit 14 detected by the pressure detection unit 11 (step S102).
  • the control unit 15 determines whether or not the contact pressure at the contact unit 14 is equal to or higher than a predetermined pressure stored in the storage unit 17 based on the acquired pressure signal (step S103).
  • control unit 15 determines that the contact pressure is equal to or higher than the predetermined pressure (Yes in step S103)
  • the control unit 15 causes the calculation unit 20 to execute the calculation algorithm described above and calculate the measurement accuracy derived by the equation (1). (Step S104).
  • the control unit 15 causes the storage unit 17 to store the measurement accuracy calculated by the calculation unit 20. Then, the process proceeds to step S106.
  • step S103 when the control unit 15 determines that the contact pressure is less than the predetermined pressure (No in step S103), the control unit 15 performs a notification instructing to increase the contact pressure from the notification unit 16 (step S105). Then, the process proceeds to step S106.
  • Control part 15 judges whether acquisition of a living body measurement output by living body sensor 13 was completed after Step S104 or Step S105 (Step S106).
  • control unit 15 determines that the acquisition of the biometric output is not completed (No in Step S106)
  • the control unit 15 proceeds to Step S102 while continuing to acquire the biometric output.
  • control unit 15 determines that the acquisition of the biometric output is completed (Yes in Step S106)
  • the control unit 15 stops the emission of the laser light from the light source 21 (Step S107).
  • the control unit 15 generates biological information based on the acquired biological measurement output (step S108). At this time, the control unit 15 may store the generated biological information in the storage unit 17.
  • control part 15 displays the measurement result of biometric information on the display part 18 (step S109).
  • the control unit 15 displays the measurement accuracy calculated by the calculation unit 20 together with the measurement result of the biological information.
  • the control unit 15 may display that the measurement accuracy is extremely low when the calculation unit 20 has not calculated the measurement accuracy (No in step S103).
  • the control unit 15 may display information related to measurement accuracy with a numerical value “0”.
  • the measurement apparatus 10 can notify the subject by displaying the measurement accuracy of the measured biological information on the display unit 18 together with the measurement result of the biological information. Therefore, the subject can determine whether the reliability of the measurement result is high by checking the measurement accuracy of the displayed measurement result. In this way, convenience is improved by the measuring apparatus 10.
  • the control unit 15 causes the calculation unit 20 to calculate information regarding measurement accuracy when the contact pressure is equal to or higher than a predetermined pressure, and when the contact pressure is less than the predetermined pressure, the control unit 15 transmits information regarding the measurement accuracy to the calculation unit 20. Do not calculate. That is, the control unit 15 causes the calculation accuracy to be calculated by applying the calculation algorithm when the function as the measurement accuracy can be achieved. Therefore, the reliability of measurement accuracy can be maintained above a certain level.
  • control unit 15 can increase the contact pressure by performing a notification from the notification unit 16 to instruct to increase the contact pressure when the contact pressure is lower than the predetermined pressure. Is more likely to be adjusted to a predetermined pressure or higher. As a result, the measurement apparatus 10 is more likely to display measurement accuracy.
  • the measuring device 10 measures biological information both when the contact pressure is equal to or higher than a predetermined pressure and lower than the predetermined pressure, and therefore, compared with a measurement device that does not start measurement unless the contact pressure is a predetermined pressure, The mental burden of the subject that the contact pressure must be adjusted can be reduced.
  • each component, each step, etc. can be rearranged so that there is no logical contradiction, and multiple components, steps, etc. can be combined or divided into one It is.
  • the measuring device 10 only needs to have an arbitrary information output unit capable of notifying the subject of biological information and information on measurement accuracy.
  • the information output unit outputs information by a visual or auditory method, or any other method that can be recognized by the subject, like the notification unit 16 in the above embodiment.
  • the calculation unit 20 calculates the measurement accuracy by the equation (1), but the calculation of the measurement accuracy may be performed by another appropriate calculation equation.
  • the calculation unit 20 may calculate the measurement accuracy using Expression (35).
  • Equation (35) F represents the amount of blood that passes through a certain section of the blood vessel per unit time.
  • FIG. 10 is a schematic diagram showing a blood vessel and blood flow of a subject.
  • the amount F of blood that passes through the cross section per unit time is expressed by equation (36) by the pulse pressure ⁇ P and the vascular resistance R.
  • the pulse pressure ⁇ P is a difference between systolic blood pressure (maximum blood pressure) and diastolic blood pressure (minimum blood pressure).
  • the vascular resistance R is expressed as the equation (37) by the viscosity V of blood, the length L of the blood vessel, and the inner diameter r I of the blood vessel.
  • the blood viscosity V is determined by the calculation unit 20 with reference to data stored in the storage unit 17 based on information on the subject, for example.
  • the calculation unit 20 may calculate the measurement accuracy using, for example, the equation (38).
  • Equation (38) is the average rate of change when Equation (1) is sampled in unit time.
  • the calculation unit 20 calculates the measurement accuracy as a numerical value of time average over the time when the biometric measurement output is acquired. Therefore, in this case, the control unit 15 displays the measurement accuracy as a numerical value on the display unit 18 instead of the graph shown in FIG.
  • the computing unit 20 determines whether or not Expression (39) is satisfied for each sampling of the biological measurement output, for example.
  • T upper and T lower are predetermined thresholds satisfying T upper ⁇ T lower .
  • the calculation unit 20 may count the number of samplings satisfying Expression (39) among the total number of samplings, and determine the ratio of the number of samplings satisfying Expression (39) to the total number of samplings as the measurement accuracy.
  • FIG. 11 is a diagram showing an example of a mobile phone equipped with the measuring apparatus 10 of FIG. As shown in FIG. 11A, the mobile phone 30 includes a measuring device 10 on the back side thereof.
  • FIG. 11B is a diagram illustrating an example of a case where the subject uses the mobile phone 30 including the measurement device 10 to measure biological information.
  • the subject causes the measuring device 10 to measure biological information by bringing a finger into contact with the contact portion 14 of the measuring device 10.
  • the functions of the functional units of the measuring device 10 shown in FIG. 1 may be included in the functional units of the electronic device.
  • the control unit 15 may use a notification function unit included in the mobile phone 30 as the notification unit 16.
  • the arrangement of the measuring apparatus 10 in the mobile phone 30 is not limited to that shown in FIG.
  • the measuring device 10 may be disposed on another part of the back surface of the mobile phone 30, or may be disposed on the surface or side surface of the mobile phone 30.
  • the electronic device on which the measuring apparatus 10 is mounted is not limited to the mobile phone 30.
  • the measuring apparatus 10 can be mounted on a wide variety of electronic devices such as a portable music player, a notebook computer, a wristwatch, a tablet terminal, and a game machine.
  • the control unit 15 included in the measurement device 10 has been described as generating biological information based on the output of the light receiving unit 22.
  • the generation of biological information is performed by the control unit 15 included in the measurement device 10. It is not limited to doing.
  • a server device connected to the measurement device 10 via a wired or wireless network or a combination thereof includes a functional unit corresponding to the control unit 15 and the calculation unit 20, and generation of biological information and calculation of measurement accuracy are performed.
  • the server apparatus having this function unit may be used.
  • the measurement apparatus 10 acquires the biometric information output by the biometric sensor 13, and transmits the acquired biometric information output to the server apparatus from a separately provided communication unit.
  • a server apparatus produces
  • the server device transmits the generated biological information and the calculated measurement accuracy to the measurement device 10.
  • the measurement device 10 can be reduced in size and the like as compared with the case where all the functional units illustrated in FIG. 1 are realized on one measurement device 10. .

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  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
PCT/JP2015/004230 2014-08-27 2015-08-24 測定装置及び測定方法 WO2016031222A1 (ja)

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JPH05253308A (ja) * 1992-03-10 1993-10-05 Olympus Optical Co Ltd 加温治療装置
JP2004180982A (ja) * 2002-12-04 2004-07-02 Yaskawa Electric Corp 足筋力計測装置
JP2009172097A (ja) * 2008-01-23 2009-08-06 Omron Healthcare Co Ltd 血圧計および血圧計の測定精度確認システム

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JPH0321208Y2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1986-11-19 1991-05-09
WO1994015525A1 (en) * 1993-01-06 1994-07-21 Seiko Epson Corporation Pulse wave processor
KR100493157B1 (ko) * 2002-08-02 2005-06-03 삼성전자주식회사 생체신호 측정에 사용되는 프로브 및 이를 포함하는생체신호 측정용 시스템
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JPH05253308A (ja) * 1992-03-10 1993-10-05 Olympus Optical Co Ltd 加温治療装置
JP2004180982A (ja) * 2002-12-04 2004-07-02 Yaskawa Electric Corp 足筋力計測装置
JP2009172097A (ja) * 2008-01-23 2009-08-06 Omron Healthcare Co Ltd 血圧計および血圧計の測定精度確認システム

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