WO2016030060A1 - Préparations pauvres en électrolytes destinées à éliminer les odeurs corporelles - Google Patents

Préparations pauvres en électrolytes destinées à éliminer les odeurs corporelles Download PDF

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Publication number
WO2016030060A1
WO2016030060A1 PCT/EP2015/065181 EP2015065181W WO2016030060A1 WO 2016030060 A1 WO2016030060 A1 WO 2016030060A1 EP 2015065181 W EP2015065181 W EP 2015065181W WO 2016030060 A1 WO2016030060 A1 WO 2016030060A1
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Prior art keywords
cosmetic
composition according
weight
cosmetic composition
carbon atoms
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PCT/EP2015/065181
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German (de)
English (en)
Inventor
Thomas Döring
Gertraud Teckenbrock
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Henkel Ag & Co. Kgaa
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Publication of WO2016030060A1 publication Critical patent/WO2016030060A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/046—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/342—Alcohols having more than seven atoms in an unbroken chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group

Definitions

  • the present application relates to aqueous-ethanolic cosmetic deodorants used in metallic containers, i. in particular containers with metallic inner surface or elements that are in contact with the deodorant, filled and stored without significant corrosion occurs.
  • washing, cleansing and caring for one's own body is a fundamental human need, and modern industry is constantly trying to meet these needs of man in a variety of ways. Especially important for daily hygiene is the permanent elimination or at least reduction of body odor.
  • Numerous specific deodorant or antiperspirant personal care products are known in the art which have been developed for use in body regions having a high density of sweat glands, especially in the underarm area. These are formulated in a wide variety of dosage forms, for example as powder, in stick form, as aerosol spray, pump spray, liquid and gel roll on application, cream, gel and as a soaked flexible substrate (towels).
  • Cosmetic compositions especially deodorants and antiperspirants, usually contain at least one oil or one fatty substance and in any case always a fragrance component or a perfume.
  • Ethanol is a preferred solvent in deodorants as it provides a cool and fresh-to-dry sensation to the skin when applied to the skin.
  • the preferred form of application here are aerosols.
  • high purity 99.5 to 100% ethanol (200 proof) ethanol is often used.
  • water-based ethanol of 95 to 99.5% (190 proof) may cause corrosion.
  • high-purity ethanol is not always commercially available and, compared to water-containing ethanol, more expensive to produce and therefore also more expensive.
  • Electrolytes Active substances to prevent body odor are often electrolytes, e.g. Cocamidopropyl PG-Dimonium Chloride Phosphate, Silver Lactate, Zinc Ricinoleate, Aluminum Sulfate, Polyamino Biguanide Stearate etc.
  • ethanol-containing preparations with water contents of z. B. 1 to 5 wt .-% and over more than 24h lasting effect against body odor without risk of corrosion in metal aerosol containers can be stored if the electrical conductivity of the preparation is less than 50 ⁇ / ⁇ and at least two different alcohols or polyols with 8 or more carbon atoms are contained as deodorant agents in a total concentration of at least 0.5 wt .-%.
  • the present application thus provides:
  • a deodorant cosmetic agent in a container which has at least one metallic surface area in contact with the cosmetic agent during storage or dosage of the cosmetic agent and / or at least one metallic component in contact with the cosmetic agent, the cosmetic agent containing :
  • the cosmetic agent has an electrical conductivity of 50 ⁇ / ⁇ or less.
  • Cosmetic composition according to item 1 wherein the container is a metal aerosol spray container.
  • a cosmetic composition according to item 1 or 2 wherein the aliphatic alcohol compounds are selected from the group consisting of a saturated aliphatic compound having one or more 1,2-alkanediol group (s) and a monohydric alcohol.
  • Cosmetic agent according to one of the preceding points wherein the compound having one or more 1, 2-alkanediol group (s) a linear or branched 1, 2-alkanediol having 8 to 12 carbon atoms, a linear or branched 1, 2-alkane diol ethers 8 to 30 carbon atoms and / or a linear or branched 1, 2-alkanediol ester having 8 to 30 carbon atoms.
  • the 1, 2-alkanediol is 1, 2-octanediol and / or 1, 2-decanediol.
  • 1, 2-alkanediol ether is an a- monoalkyl glycerol ether having a branched or linear saturated or unsaturated C 8 -C 22 alkyl radical, preferably ⁇ - (2-ethylhexyl) glycerol ether.
  • composition according to one of the preceding points wherein the 1, 2-alkanediol ester is a carboxylic acid ester of mono-, di- and / or triglycerol, preferably glycerol monocaprylate (INCI: glyceryl caprylates), glycerol dicaprylates (INCI: polyglyceryl 2-caprylates) and / or glycerol tricaprylates (INCI: polyglyceryl 3-caprylates).
  • Cosmetic composition according to item 8 wherein the monohydric alcohol is 2-methyl-5-cyclohexylpentanol.
  • composition according to one of the preceding claims, wherein the agent further comprises one or more of the following compounds: phenoxyethanol, one or more tropolones, triethyl citrate.
  • composition according to one of the preceding claims, wherein the agent contains as deodorant active ingredient 1, 2-octanediol and further 1, 2-hexanediol.
  • a cosmetic agent which 0, 1 to 5.0 wt .-% water, ethanol and 0.1 to 5.0 wt .-% of at least two different nonionic saturated aliphatic alcohol compounds having 8 or more carbon atoms as deodorant agents contains, and which has an electrical conductivity of 50 ⁇ / ⁇ or less, as the content of a container such that at least one metallic surface area and / or at least one metallic component of the container is in contact with the cosmetic agent during storage or dosage of the cosmetic product , 14.
  • a method for non-therapeutic, cosmetic deodorant treatment of the body wherein the deodorant described in any one of items 1 to 12 from the container on the skin, in particular the skin of the armpits, is applied.
  • a process for the preparation of a deodorant cosmetic agent in the form of an aerosol which comprises using a cosmetic agent which contains 0, 1 to 5.0% by weight of water, ethanol and 0, 1 to 5.0% by weight. containing at least two different nonionic saturated aliphatic alcohol compounds having 8 or more carbon atoms as deodorant agents, and having an electrical conductivity of 50 ⁇ / ⁇ or less, optionally together with a blowing agent, fills in an aerosol spray container, which at least one metallic surface area and / or at least one metallic component which is in contact with the cometic agent upon storage or dosage of the cosmetic composition.
  • all containers are suitable according to the invention as a container, which have a surface at risk of corrosion of a corrosion-prone component, that is, for example, a surface or a component made of aluminum or tinplate.
  • Inventive agents are preferably packaged for use as aerosol, that is, they are packaged in a pressure vessel, from which they can be sprayed by means of a propellant.
  • the packaging in other dosage forms, such as in a deodorant scooter with metallic inner surface, but is also included according to the invention.
  • the agents according to the invention are in liquid or viscous, flowable form.
  • the application is preferably carried out with spray devices. These spraying devices contain in a container a filling of the liquid, viscous-flowable or suspensionsformigen deodorant according to the invention.
  • the filling is usually under the pressure of a propellant (compressed gas cans, aerosols, aerosols).
  • the containers have a removal device, preferably in the form of valves, which allow the removal of the contents as fog, smoke, foam, powder, paste or liquid jet.
  • a container for the sprayers are mainly cylindrical vessels made of metal (aluminum, tinplate, volume preferably a maximum of 1000 ml) in question.
  • Creamy, gelatinous, pastose and liquid agents may be packaged, for example, in pump, spray or squeeze dispensers, in particular also in multi-chamber pumping, multi-chamber spray or multi-chamber Quetschspendern.
  • the packaging for the compositions according to the invention may be opaque, but also transparent or translucent.
  • liquid also includes any solid dispersions in liquids.
  • Compositions according to the invention may also be present as pastes, ointments, lotions or creams.
  • Solid funds can be present as a loose powder, pressed powder or as a pen.
  • the application can also be carried out with a roller applicator, as described e.g. is known from the field of deodorant scooters.
  • a roller applicator as described e.g. is known from the field of deodorant scooters.
  • Such scooters have a ball mounted in a ball bed which can be moved by movement over a surface. The ball absorbs some of the agent to be distributed and conveys this to the surface to be treated.
  • the agents according to the invention may also be multiphase, the phases may e.g. horizontally, so one above the other, or vertically, so next to each other, be arranged. It may also be a disperse system in which e.g. the solid constituents are distributed inhomogeneously in the liquid matrix, so that such a dispersed system should be shaken before use.
  • composition according to the invention are used synonymously in the present application.
  • normal conditions are a temperature of 20 ° C. and a pressure of 1013.25 mbar. Melting point data likewise relate to a pressure of 1013.25 mbar.
  • compositions according to the invention comprise as cosmetically acceptable carriers 0, 1 to 5.0% by weight of water, preferably 0.5 to 5.0% by weight of water, and ethanol.
  • the cosmetically acceptable carrier is from 0.1 to 5.0% by weight of water and ethanol. Accordingly, according to the invention there is the great advantage that ethanol which is commercially available as a cosmetically acceptable carrier and having a water content of from 0.5 to 5.0% by weight can preferably be used.
  • Agents preferred according to the invention, such as ethanol-based deodorant sprays preferably contain from 1.0 to 4.5% by weight, also preferably from 1.5 to 4.0% by weight, more preferably from 2.5 to 4.0% by weight.
  • % free that is, not molecularly bound, water, with the quantities given refer to the weight of the composition, without taking into account any existing propellant.
  • the content of water of crystallization, water of hydration or similar molecularly bound water, which is contained in the constituents used, does not constitute free water in the sense of the present application.
  • the cosmetic agent contains as a cosmetically acceptable carrier 96% ethanol in an amount of 60 to 97 wt.%, More preferably 70 to 95 wt .-%, further preferably 80 to 90 wt .-%, wherein the wt .-% - refer to the total weight of the composition, without taking into account any existing propellant.
  • the cosmetically acceptable carrier may comprise further components, for example a cosmetic oil which is liquid under standard conditions and which is not a fragrance and is not an essential oil, and talcum and mixtures thereof. Under normal conditions liquid cosmetic oils are immiscible with water. As far as in the present application of a cosmetic oil is mentioned, this is always a cosmetic oil that is not a fragrance and no essential oil, is liquid under normal conditions and immiscible with water.
  • compositions according to the invention are present as deodorants and contain as nonionic deodorant active ingredient at least two saturated aliphatic alcohol compounds having 8 or more carbon atoms in a total amount of 0.1-5.0% by weight, preferably 0.2-3.0% by weight. %, more preferably 0.3-2.0% by weight, also preferably 0.5-1.5% by weight, and most preferably 0.7-1.0% by weight, wherein the weight percentages % Information on the total weight of the composition, without taking into account any existing propellant.
  • ethanol does not count as a deodorant active ingredient, but, if present, only as a constituent of the carrier.
  • deodorant actives contain at least two different nonionic saturated aliphatic alcohol compounds having 8 or more carbon atoms in a proportion of 0.1 to 5.0% by weight.
  • the alcohols may be monohydric alcohols or polyols.
  • the aliphatic alcohol compounds according to the invention are selected in particular from the group consisting of saturated aliphatic compounds with one or more 1, 2-alkanediol group (s) and monohydric alcohols.
  • the compound having one or more 1,2-alkanediol group (s) is preferably a linear or branched 1,2-alkanediol having 8 to 12 carbon atoms, a linear or branched 1, 2 Alkandiolether having 8 to 30 carbon atoms and / or a linear or branched 1, 2-alkanediol ester having 8 to 30 carbon atoms.
  • the 1,2-alkanediol is preferably a linear 1, 2-alkanediol having 8 to 12 carbon atoms, which is described by the formula HO-CH 2 -CH (OH) - (CH 2) n -CH 3 , in which n is the numbers 5, 6, 7, 8 or 9, as well as mixtures of these 1, 2-alkanediols.
  • 1, 2-alkanediols having 8 to 12 C atoms which are particularly preferred according to the invention are selected from 1,2-octanediol, 1,2-decanediol and mixtures thereof.
  • n is the number 5, 6, 7, 8 or 9 is one or more further alkanediols having 5 to 7 carbon atoms, in particular 1, 2-pentanediol and / or 1, 2-hexanediol.
  • mixtures of 1, 2-hexanediol and 1, 2-octanediol preferably in a weight ratio of 5: 1 to 1: 5, preferably in a weight ratio of about 1: 1 in the cosmetic composition.
  • Such mixtures are commercially available, for example, under the name Symdiol® 68 (Symrise).
  • Preferred agents according to the invention comprise the at least one 1,2-alkanediol having 8 to 12 C atoms, which is described by the formula HO-CH 2 -CH (OH) - (CH 2) n -CH 3, in which n represents the numbers 5, 6, 7, 8 or 9, in a total amount of 0, 1-3 wt .-%, more preferably 0.2 to 1 wt .-%, particularly preferably 0.2 to 0.5 wt .-%, each based on the weight of the composition, without taking into account any existing propellant.
  • the 1,2-alkanediol ether is preferably an ⁇ -monoalkyl glycerol ether having a branched or linear saturated or unsaturated C 8 -C 22 -alkyl radical.
  • a preferred such 1, 2-alkanediol ether is ⁇ - (2-ethylhexyl) glycerol ether, commercially available as Sensiva® SC 50 (ex Schülke & Mayr).
  • the 1,2-alkanediol ether is preferably contained in an amount of 0.2 to 1.0% by weight in the cosmetic composition, more preferably 0.3 to 0.5% by weight.
  • the linear or branched 1,2-alkanediol ester as deodorant active ingredient is preferably a carboxylic acid ester of mono-, di- or triglycerol.
  • these are glycerol monolaurate, diglycerol monocaprate, triglycerol acrylate, diglyceryl acrylate and glycerol acrylate, of which triglyceryl acrylate (eg Tego® Cosmo P813, Evonik), diglycerol acrylate (eg Dermosoft® GMCY, Dr. Straetmans) and glycerol acrylate (eg Dermosoft® DGMC, Dr.
  • triglyceryl acrylate eg Tego® Cosmo P813, Evonik
  • diglycerol acrylate eg Dermosoft® GMCY, Dr. Straetmans
  • glycerol acrylate eg Dermosoft® DGMC, Dr.
  • the 1,2-alkanediol ester is preferably present in an amount of 0.05 to 1.0% by weight in the cosmetic composition, furthermore preferably 0.1 to 0.5% by weight, and also preferably 0.2 to 0 , 3% by weight.
  • the monohydric alcohol as the deodorant active is preferably a linear or branched alcohol having 8 to 30 carbon atoms, more preferably 8 to 12 carbon atoms, having a terminal OH group. Furthermore, the monohydric alcohol preferably has an alicyclic ring.
  • a preferred example of such a deodorant active ingredient is 2-methyl-5-cyclohexylpentanol, commercially available, for example, as SymDeo® B125 (Symrise).
  • the monohydric alcohol is preferably contained in an amount of 0.1 to 1.0% by weight in the cosmetic composition, further preferably 0.2 to 0.8% by weight, also preferably 0.3 to 0.7% by weight .-%.
  • the electrical conductivity of the cosmetic composition is 50 ⁇ / ⁇ or less.
  • maintaining the value of the electric conductivity of 50 ⁇ / ⁇ or less alone is not enough to sufficiently reduce corrosion. It has been surprisingly found in the present invention, however, that this value or lower values of electrical conductivity in combination with the use of said nonionic deodorant agents in a concentration of at least 0.5 wt .-% of the occurrence of corrosion in containers with metallic surfaces and / or components that are in contact with the composition reliably and permanently prevented.
  • the value of the electrical conductivity was determined in the present invention using the Condhmometer 856 from Metrohm.
  • the electrical conductivity of the cosmetic composition is according to the invention 0 to 50 ⁇ / ⁇ , preferably 20 to 45 ⁇ / ⁇ , more preferably 30 to 40 ⁇ / ⁇ .
  • the agents according to the invention comprise as further deodorizing agent at least one aromatic alcohol of structure (AA-1), R 5 R 3 R 1
  • the radicals R to R 6 independently of one another represent a hydrogen atom, an alkyl group having 1 to 10 carbon atoms, which may be linear or branched and substituted by OH groups or alkoxy groups having 1 to 5 carbon atoms, or an alkenyl group having 2 to 10 carbon atoms, which may be linear or branched and substituted with OH groups or alkoxy groups having 1 to 5 carbon atoms,
  • radicals R 7 to R independently of one another are a hydrogen atom, a halogen atom, in particular a chlorine atom, or an alkyl group having 1 to 10 carbon atoms, which may be linear or branched and substituted by OH groups or alkoxy groups having 1 to 5 carbon atoms, in particular with a methoxy group,
  • n, o, p are independently integers from 0 to 10, with at least one of the values n, o, p ⁇ 0.
  • Particularly preferred products according to the invention contain at least one alcohol AA-1, as described above, which is selected from phenoxyethanol, anisalcohol, 2-methyl-5-phenylpentan-1-ol, 1, 1-dimethyl-3-phenylpropane 1-ol, benzyl alcohol, 2-phenylethan-1-ol, 3-phenylpropan-1-ol, 4-phenylbutan-1-ol, 5-phenylpentan-1-ol, 2-benzylheptan-1-ol, 2, 2-Dimethyl-3-phenyl-propan-1-ol, 2,2-dimethyl-3- (3'-methyl-phenyl) -propan-1-ol, 2-ethyl-3-phenylpropan-1-ol, 2-ethyl -3- (3'-methylphenyl) -propan-1-ol, 3- (3'-chlorophenyl) -2-ethyl-propan-1-ol, 3- (2'-chlorophenyl) -2
  • compositions according to the invention comprise at least one alcohol AA-1, as described above, in a total amount of 0.05-10% by weight, preferably 0.1-1.5% by weight, more preferably 0.2-2% by weight .-%, most preferably 0.3 to 1, 5 wt .-%, each based on the weight of the composition, without taking into account any existing propellant.
  • the cosmetic composition may furthermore comprise as further deodorant active ingredient at least one compound from the group of tropolones (I)
  • very particularly preferred tropolones are the alpha-tropolone and the three isomeric thujaplicins.
  • Preferred uses according to the invention are characterized in that the or the 1,2-alkanediol (s) together with at least one compound from the group
  • the cosmetic composition particularly preferably contains tropolone (2-hydroxy-2,4,6-cycloheptatrienone), preferably in an amount of 0.001-0.1% by weight, based on the weight of the composition, without taking into account any propellant present ,
  • agents according to the invention are characterized by a content of the deodorant active ingredient triethyl citrate.
  • Triethyl citrate is a known deodorant active which acts as an enzyme inhibitor for esterases and lipases and thus contributes to the broad spectrum effect of agents according to the invention.
  • Preferred agents according to the invention contain from 0.5 to 15% by weight, preferably from 3 to 8% by weight, most preferably from 4 to 7% by weight, based in each case on the weight of the composition, without taking into account any blowing agent present.
  • the cosmetic composition may further contain, as an antibacterial deodorant active ingredient, tea tree oil which is commercially available as Melalleuca Alternifolia Leaf Oil, for example as Melafresh® T96 from Southern Cross Botanicals.
  • tea tree oil which is commercially available as Melalleuca Alternifolia Leaf Oil, for example as Melafresh® T96 from Southern Cross Botanicals.
  • the amount thereof is preferably 0.01 to 0.5 wt .-%, more preferably 0.05 to 0.2 wt .-%, each based on the weight of the composition, without taking into account any existing propellant.
  • Apocrine sweat is a complex mixture that includes sebum and other fats as well as steroids.
  • Steroids themselves are not water soluble. In order to be carried away with the body fluids, they are usually present as sulfate or as glucuronide.
  • On the Skin is the cleavage of these steroid esters in the volatile free steroids by hydrolytic enzymes of the skin bacteria, especially the coryneform bacteria. In principle all bacterial exoesterases are capable of this, but especially the enzymes arylsulfatase and beta-glucuronidase. Compounds which inhibit arylsulfatase or beta-glucuronidase therefore represent preferred deodorant active ingredients according to the invention.
  • Corynebacterium A both short - chain C2 - Cs fatty acids and medium chain C6 - Ci2 fatty acids are formed, which are mainly responsible for the axillary body odor.
  • all bacterial exoesterases are capable of this lipid cleavage, but especially the enzyme lipase.
  • Compounds which inhibit lipase are therefore also preferred deodorant agents according to the invention.
  • Another class of compounds which also results from the bacterial decomposition of the sweat constituents and which contributes to body odor are saturated and unsaturated aldehydes, especially those with a chain length of C6-C12, in particular hexanal, heptanal, octenal and nonenal. These are formed by beta-cleavage from the hydroperoxides, which are formed by the action of the 5-lipoxygenase on unsaturated fatty acids. Compounds which inhibit the enzyme 5-lipoxygenase are therefore also preferred deodorant agents according to the invention.
  • VSC volatile sulfur compounds released by enzymatic reaction
  • Sulfur-containing compounds come as water-soluble amino acid conjugates with sweat on the human skin They are released by enzymatic reactions from skin bacteria (especially staphylococci and corynebacteria), an enzyme that plays a key role in the release of VSCs, cystathionine beta-lyase, which cleaves VSCs from the amino acids and thus is an important cause in the development of body odor compounds which inhibit the enzyme cystathionine beta-lyase, therefore, also according to the invention are preferred deodorant agents.
  • compositions according to the invention are characterized by a content of at least one compound which is an inhibitor of the enzyme arylsulfatase.
  • preferred Deodorant active ingredients which act as arylsulfatase inhibitors are those disclosed in US 5643559, US 5676937, WO2001 / 099376 A2, EP1430879 A1 and DE 10216368 A1.
  • agents according to the invention are characterized by a content of at least one compound which is an inhibitor of the enzyme arylsulfatase, in a total amount of 0.001-10 wt.%, Preferably 0.01-5 wt.%, Particularly preferably 0, 1 - 2.5 wt .-%, each based on the weight of the composition, without taking into account any existing propellant.
  • Further preferred agents according to the invention are characterized by a content of at least one compound which is an inhibitor of the enzyme beta-glucuronidase.
  • Deodorant active ingredients which are active according to the invention and act as a beta-glucuronidase inhibitor are those disclosed in WO2003 / 039505 A2.
  • Further particularly preferred agents according to the invention are characterized by a content of at least one compound which is an inhibitor of the enzyme beta-glucuronidase, in a total amount of 0.001-10% by weight, preferably 0.01-5% by weight, more preferably 0, 1 - 2.5 wt .-%, each based on the weight of the composition, without taking into account any existing propellant.
  • compositions according to the invention are characterized by a content of at least one compound which is an inhibitor of the enzyme lipase.
  • preferred deodorant active ingredients which act as lipase inhibitor are selected from those disclosed in EP 1428520 A2, further selected from the aminomethylenemalonic acid derivatives according to DE 3018132 A1, the ethylene oxide-propylene oxide copolymers according to GB 2335596 A1 and the salts of Phytic acid according to EP 650 720 A1.
  • agents according to the invention are characterized by a content of at least one compound which is an inhibitor of the enzyme lipase, in a total amount of 0.001-10 wt.%, Preferably 0.01-5 wt.%, Particularly preferably 0, 1 - 2.5 wt .-%, each based on the weight of the composition, without taking into account any existing propellant.
  • agents according to the invention are characterized by a content of at least one compound which is an inhibitor of 5-lipoxygenase.
  • Deodorant active ingredients which are preferred according to the invention and act as 5-lipoxygenase inhibitors are disclosed in EP 1428519 A2.
  • Further particularly preferred agents according to the invention are characterized by a content of at least one compound which is an inhibitor of the enzyme 5-lipoxygenase, in a total amount of 0.001-10% by weight, preferably 0.01-5% by weight, more preferably 0.1 - 2.5 wt .-%, each based on the weight of the composition, without taking into account any existing propellant.
  • agents according to the invention are characterized by a content of at least one compound that is an inhibitor of the enzyme cystathionine beta-lyase.
  • Deodorant active ingredients which are preferred according to the invention and act as inhibitors of cystathionine beta-lyase are selected from those disclosed in EP 495918 B1, WO 2006/079934, DE 10201000046 A1, WO2010 / 031657 A1 and WO2010 / 046291 A1.
  • agents according to the invention are characterized by a content of at least one compound which is an inhibitor of the enzyme cystathionine beta-lyase, in a total amount of 0.001-10% by weight, preferably 0.01-5% by weight, particularly preferably 0.1-2.5% by weight, based in each case on the weight of the composition, of any propellant which may be present.
  • deodorant active ingredients are odor absorbers, deodorizing ion exchangers, antimicrobial agents, prebiotic components and enzyme inhibitors or, more preferably, combinations of said active ingredients.
  • Silicates serve as odor absorbers, which at the same time advantageously support the rheological properties of the composition according to the invention.
  • silicates particularly preferred according to the invention are, in particular, phyllosilicates and, among these, in particular montmorillonite, kaolinite, mit, beidellite, nontronite, saponite, hectorite, bentonite, smectite and talcum.
  • Other preferred odor absorbers are, for example, zeolites, Zinkricinoleat, cyclodextrins, certain metal oxides, such as. As alumina, and chlorophyll. They are preferably in a total amount of 0.1 to 10 wt .-%, more preferably 0.5 to 7 wt .-% and most preferably 1-5 wt .-%, each based on the total composition without propellant, included.
  • germ-inhibiting or antimicrobial active ingredients are understood as meaning those active substances which reduce the number of skin germs participating in the formation of the odor or inhibit their growth.
  • These organisms include, among others, various species from the group of staphylococci, the group of Corynebacteria, anaerococci and micrococci.
  • germ-inhibiting or antimicrobial agents are particularly preferred organohalogen compounds and halides and a number of plant extracts and. These include u. a. Triclosan, chlorhexidine and 3,4,4'-trichlorocarbanilide, bromochlorophene, dichlorophen, chlorothymol, chloroxylenol, hexachlorophene, dichloro-m-xylenol. Furthermore, phenol, terpene alcohols such. As farnesol and chlorophyllin copper complexes preferred deodorant agents.
  • Preferred deodorant compositions according to the invention contain as further constituent at least one deodorant active ingredient which is selected from aromatic alcohols of structure AA-1 with the abovementioned substituents, preferably phenoxyethanol, 1,2-alkanediols having 5 to 7 carbon atoms, tropolone, triethyl citrate and Mixtures thereof.
  • deodorant active ingredient selected from aromatic alcohols of structure AA-1 with the abovementioned substituents, preferably phenoxyethanol, 1,2-alkanediols having 5 to 7 carbon atoms, tropolone, triethyl citrate and Mixtures thereof.
  • Antioxidant substances can counteract the oxidative decomposition of the welding components and in this way inhibit odor development.
  • Preferred antioxidants are imidazole and Imidazole derivatives (eg, urocanic acid), peptides, such as. B.
  • D, L-carnosine, D-carnosine, L-carnosine and their derivatives eg., Anserin
  • carotenoids eg., carotenes (eg, ⁇ -carotene, ß-carotene, lycopene) and their derivatives, lipoic acid and their derivatives (eg dihydrolipoic acid), aurothioglucose, propylthiouracil and other thio compounds (eg thioglycerol, thiosorbitol, thioglycolic acid, thioredoxin, glutathione, cysteine, cystine, cystamine and their glycosyl, N-acetyl, methyl, ethyl , Propyl, amyl, butyl, lauryl, palmitoyl, oleyl, ⁇ -linoleyl, cholesteryl and glyceryl esters) and their salts, dilauryl thiod
  • Preferred lipophilic, oil-soluble antioxidants from this group are tocopherol and its derivatives, in particular tocopheryl acetate (vinylamine acetate), and carotenoids, as well as butylhydroxytoluene and butylhydroxyanisole.
  • compositions according to the invention which are in the form of an emulsion or suspension preferably also contain at least one liquid under normal conditions, which is not a fragrance and is not an essential oil.
  • the cosmetic oil is liquid under normal conditions.
  • Essential oils according to the invention are understood to mean mixtures of volatile components which are prepared by steam distillation from vegetable raw materials, such as. B. citrus oils.
  • Particularly preferred deodorant or antiperspirant compositions according to the invention also contain at least one perfume.
  • the definition of a fragrance in the sense of the present application is in accordance with the expert definition as it can be found in the R ⁇ MPP Chemie Lexikon, as of December 2007. Thereafter, a fragrance is a chemical compound with odor and / or taste that excites the hair cell receptors of the olfactory system (adequate stimulus).
  • the necessary physical and chemical properties are a low molecular weight of at most 300 g / mol, a high vapor pressure, minimal water and high lipid solubility and weak polarity and the presence of at least one osmophoric group in the molecule.
  • fragrances according to the invention have a molecular weight from 74 to 300 g / mol, contain at least one osmophoric group in the molecule and have an odor and / or taste, that is, they excite the hair cell receptors of the olfactory system.
  • perfumes perfumes, perfume oils or perfume oil ingredients can be used.
  • perfume oils or fragrances can according to the invention individual fragrance compounds, eg.
  • ethers, aldehydes, ketones, alcohols and hydrocarbons e.g.
  • Fragrance compounds of the ester type are known e.g.
  • the ethers include, for example, benzyl ethyl ether and ambroxane, to the aldehydes e.g.
  • the linear alkanals of 8 - 18 C atoms citral, citronellal, citronellyloxy-acetaldehyde, cyclamen aldehyde, lilial and bourgeonal, to the ketones e.g. the ionones, alpha-lsomethylionone and methylcedryl ketone, the alcohols anethole, citronellol, eugenol, geraniol, linalool, phenylethyl alcohol and terpineol, the hydrocarbons mainly include the terpenes such as limonene and pinene. Preferably, however, mixtures of different fragrances are used, which together produce an attractive fragrance.
  • Particularly preferred deodorant or antiperspirant compositions according to the invention contain at least one perfume in a total amount of 0.00001 to 10 wt .-%, preferably 0.5 to 7 wt .-%, most preferably 1-6 wt .-%, each based on the total weight of the agent, without taking into account any existing propellant.
  • composition of some preferred cosmetic agents can be found in the following tables (figures in% by weight based on the total weight of the cosmetic composition, if not stated otherwise, without taking into account any possibly used propellant).
  • Triethyl citrate 0.5 to 15.0 1, 0 to 10.0 2.0 to 8.0 3.0 to 8.0 4.0 to 7.0
  • 1,2-alkanediol ester with 8 0.05 to 1.0 0.1 to 1.0 0.1 to 0.5 0.2 to 0.4 0.2 to 0.3 to 30 carbon atoms
  • 1,2-Alkandiolether with 8 0.05 to 2.0 0.1 to 1.5 0.2 to 1.0 0.3 to 0.7 0.3 to 0.5 to 30 carbon atoms
  • Triethyl citrate 0.5 to 15.0 1.0 to 10.0 2.0 to 8.0 3.0 to 8.0 4.0 to 7.0
  • 1,2-octanediol 0.05 to 3.0 0.1 to 2.0 0.15 to 0.2 to 0.7 0.2 to 0.5
  • Triglyceryl acrylate 0.05 to 1.0 0.1 to 1.0 0.1 to 0.5 0.2 to 0.4 0.2 to 0.3 diglyceryl acrylate
  • Triethyl citrate 0.5 to 15.0 1.0 to 10.0 2.0 to 8.0 3.0 to 8.0 4.0 to 7.0
  • 1,2-octanediol 0.05 to 3.0 0.1 to 2.0 0.15 to 0.2 to 0.7 0.2 to 0.5
  • Triethyl citrate 0.5 to 15.0 1.0 to 10.0 2.0 to 8.0 3.0 to 8.0 4.0 to 7.0
  • 1,2-alkanediol ester with 8 0.05 to 1.0 0.1 to 1.0 0.1 to 0.5 0.2 to 0.4 0.2 to 0.3 to 30 carbon atoms
  • 1,2-Alkandiolether with 8 0.05 to 2.0 0.1 to 1.5 0.2 to 1.0 0.3 to 0.7 0.3 to 0.5 to 30 carbon atoms
  • Triethyl citrate 0.5 to 15.0 1.0 to 10.0 2.0 to 8.0 3.0 to 8.0 4.0 to 7.0
  • Triethyl citrate 0.5 to 15.0 1.0 to 10.0 2.0 to 8.0 3.0 to 8.0 4.0 to 7.0
  • Me is to be understood as meaning ethanol as a cosmetic carrier, and possibly further customary constituents of deodorants.
  • compositions 1 to 6 were in this case in a weight ratio of 1: 3 with the propellant propane / butane (15/85) in epoxy-coated aluminum cans (varnish: PPG7940) filled with valve plate made of tinplate.
  • Sprayable deodorants (in% by weight)

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Abstract

L'invention concerne des déodorants cosmétiques, éthanoliques aqueux, qui sont remplis et stockés dans des récipients métalliques, c'est-à-dire notamment des récipients présentant une surface intérieure ou des éléments métalliques qui sont en contact avec le déodorant, sans qu'une corrosion notable ne se produise.
PCT/EP2015/065181 2014-08-29 2015-07-03 Préparations pauvres en électrolytes destinées à éliminer les odeurs corporelles WO2016030060A1 (fr)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995026708A2 (fr) * 1994-04-05 1995-10-12 Beiersdorf Ag Nouvelles compositions desodorisantes et antimicrobiennes destinees a etre utilisees dans des preparations cosmetiques ou topiques
DE19541967A1 (de) * 1995-11-10 1997-05-15 Beiersdorf Ag Gegen Bakterien, Mycota und Viren wirksame Zusammensetzungen auf der Basis von Partialglyceriden und Arylverbindungen
WO2009101216A2 (fr) * 2009-04-28 2009-08-20 Symrise Gmbh & Co. Kg Oméga-cyclohexylalcan-1-oles et leur utilisation comme antimicrobiens actifs pour lutter contre les odeurs corporelles

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3018132A1 (de) 1980-05-12 1981-11-19 Henkel Kgaa Hautpflegemittel
BR9007732A (pt) 1989-10-10 1992-08-18 Gillette Co Composicao desodorante
US5643559A (en) 1991-10-30 1997-07-01 Colgate-Palmolive Company Deodorant compositions comprising inhibitors of odor-producing axillary bacterial exoenzymes
EP0650720A1 (fr) 1993-10-28 1995-05-03 Sanwa Kagaku Kenkyusho Co., Ltd. Compositions pour le roin de la peau ou déodorant
GB2335596A (en) 1998-03-24 1999-09-29 Procter & Gamble Polyalkyleneglycol Copolymers as Lipase Inhibitors
RU2003138141A (ru) 2001-06-01 2005-06-10 Хенкель Кгаа (De) Ингибиторы арилсульфатазы в дезодорантах и антиперспирантах
DE10154368A1 (de) 2001-11-06 2003-05-15 Henkel Kgaa Beta-Glucuronidase-Inhibitoren in Deodorantien und Antitranspirantien
DE10216368A1 (de) 2002-04-12 2003-10-16 Henkel Kgaa Arylsulfatase-Inhibitoren in Deodorantien und Antitranspirantien
DE10257738A1 (de) 2002-12-10 2004-06-24 Henkel Kgaa 5-Lipoxigenase-Inhibitoren in Deodorantien und Antitranspirantien
DE10260954A1 (de) 2002-12-20 2004-07-01 Henkel Kgaa Arylsulfatase-Inhibitoren in Deodorantien und Antitranspirantien
EP1846436B1 (fr) 2005-01-31 2012-09-12 Firmenich S.A. Inhibition des mauvaises odeurs de transpiration
DE102008047743A1 (de) 2008-09-17 2010-04-15 Henkel Ag & Co. Kgaa Verwendung von Harnstoff-Derivaten und Phenacylthiazolium-Salzen zur Behandlung von Körpergeruch
DE102008053034A1 (de) 2008-10-24 2010-04-29 Henkel Ag & Co. Kgaa Verwendung von Hydroxyzimtsäuren und ihren Derivaten und/oder von Pflanzenextrakten zur Behandlung von Körpergeruch
DE102010000746A1 (de) 2010-01-08 2011-01-27 Henkel Ag & Co. Kgaa Verwendung von 1,2-Alkandiolen zur Behandlung von Körpergeruch

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995026708A2 (fr) * 1994-04-05 1995-10-12 Beiersdorf Ag Nouvelles compositions desodorisantes et antimicrobiennes destinees a etre utilisees dans des preparations cosmetiques ou topiques
DE19541967A1 (de) * 1995-11-10 1997-05-15 Beiersdorf Ag Gegen Bakterien, Mycota und Viren wirksame Zusammensetzungen auf der Basis von Partialglyceriden und Arylverbindungen
WO2009101216A2 (fr) * 2009-04-28 2009-08-20 Symrise Gmbh & Co. Kg Oméga-cyclohexylalcan-1-oles et leur utilisation comme antimicrobiens actifs pour lutter contre les odeurs corporelles

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
D M HOWARD: "Principles of corrosion of metal containers by cosmetic products", J. SOC. COSMETIC CHEMISTS, 1 January 1969 (1969-01-01), pages 17 - 29, XP055207812, Retrieved from the Internet <URL:http://journal.scconline.org/pdf/cc1969/cc020n01/p00017-p00029.pdf> [retrieved on 20150814] *

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