WO2016015596A1 - Procédé de préparation d'un composé 5-oxopyrane 2, 3-disubstitué - Google Patents

Procédé de préparation d'un composé 5-oxopyrane 2, 3-disubstitué Download PDF

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Publication number
WO2016015596A1
WO2016015596A1 PCT/CN2015/084977 CN2015084977W WO2016015596A1 WO 2016015596 A1 WO2016015596 A1 WO 2016015596A1 CN 2015084977 W CN2015084977 W CN 2015084977W WO 2016015596 A1 WO2016015596 A1 WO 2016015596A1
Authority
WO
WIPO (PCT)
Prior art keywords
compound
formula
sodium
lithium
optionally substituted
Prior art date
Application number
PCT/CN2015/084977
Other languages
English (en)
Inventor
Guodong SUN
Yongjun Liu
Mingjie WEI
Cailang LAI
Dasheng LI
Shouhua ZHANG
Zhongqing Wang
Original Assignee
Sunshine Lake Pharma Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sunshine Lake Pharma Co., Ltd. filed Critical Sunshine Lake Pharma Co., Ltd.
Priority to CN201580039019.XA priority Critical patent/CN106660981B/zh
Publication of WO2016015596A1 publication Critical patent/WO2016015596A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/18—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Selon l'invention, un procédé de préparation de composés 5-oxopyrane 2, 3-disubstitués comprend la cyclisation d'un composé en présence d'une base et d'un solvant organique.
PCT/CN2015/084977 2014-07-29 2015-07-23 Procédé de préparation d'un composé 5-oxopyrane 2, 3-disubstitué WO2016015596A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201580039019.XA CN106660981B (zh) 2014-07-29 2015-07-23 2,3-二取代-5-氧代吡喃化合物的制备方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201410367961.6 2014-07-29
CN201410367961 2014-07-29

Publications (1)

Publication Number Publication Date
WO2016015596A1 true WO2016015596A1 (fr) 2016-02-04

Family

ID=55216762

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2015/084977 WO2016015596A1 (fr) 2014-07-29 2015-07-23 Procédé de préparation d'un composé 5-oxopyrane 2, 3-disubstitué

Country Status (2)

Country Link
CN (1) CN106660981B (fr)
WO (1) WO2016015596A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112369325A (zh) * 2020-10-21 2021-02-19 甘肃亚盛农业研究院有限公司 一种植物外植体安全低毒高效灭菌的方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111320598B (zh) * 2018-12-14 2022-04-26 广东东阳光药业有限公司 一种羟基吡喃酮化合物的制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007136603A2 (fr) * 2006-05-16 2007-11-29 Merck & Co., Inc. Aminotétrahydropyranes en tant qu'inhibiteurs de la dipeptidyl peptidase-iv pour le traitement ou la prévention du diabète
WO2008060488A1 (fr) * 2006-11-14 2008-05-22 Merck & Co., Inc. Composés hétéroaromatiques tricycliques en tant qu'inhibiteurs de la dipeptidyle peptidase-iv pour le traitement ou la prévention de diabètes
WO2009014676A1 (fr) * 2007-07-23 2009-01-29 Merck & Co., Inc. Nouvelle forme cristalline d'un sel de dichlorhydrate d'un inhibiteur de la dipeptidyle peptidase iv
US20090187028A1 (en) * 2008-01-23 2009-07-23 Feng Xu Process for preparing Chiral Dipeptidyl Peptidase -IV Inhibitor Intermediates

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007097931A2 (fr) * 2006-02-15 2007-08-30 Merck & Co., Inc. Aminotétrahydropyrannes en tant qu'inhibiteurs de dipeptidylpeptidase-iv dans le traitement prophylactique ou thérapeutique du diabète
US8895603B2 (en) * 2011-06-29 2014-11-25 Merck Sharp & Dohme Corp. Crystalline forms of a dipeptidyl peptidase-IV inhibitor

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007136603A2 (fr) * 2006-05-16 2007-11-29 Merck & Co., Inc. Aminotétrahydropyranes en tant qu'inhibiteurs de la dipeptidyl peptidase-iv pour le traitement ou la prévention du diabète
WO2008060488A1 (fr) * 2006-11-14 2008-05-22 Merck & Co., Inc. Composés hétéroaromatiques tricycliques en tant qu'inhibiteurs de la dipeptidyle peptidase-iv pour le traitement ou la prévention de diabètes
WO2009014676A1 (fr) * 2007-07-23 2009-01-29 Merck & Co., Inc. Nouvelle forme cristalline d'un sel de dichlorhydrate d'un inhibiteur de la dipeptidyle peptidase iv
US20090187028A1 (en) * 2008-01-23 2009-07-23 Feng Xu Process for preparing Chiral Dipeptidyl Peptidase -IV Inhibitor Intermediates

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112369325A (zh) * 2020-10-21 2021-02-19 甘肃亚盛农业研究院有限公司 一种植物外植体安全低毒高效灭菌的方法

Also Published As

Publication number Publication date
CN106660981A (zh) 2017-05-10
CN106660981B (zh) 2019-06-25

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