WO2016013772A1

WO2016013772A1 - Production method for hydrogel mask having outstanding skin-improving effect while comprising large oil fraction, and hydrogel composition produced by means of the method

Info

Publication number: WO2016013772A1
Application number: PCT/KR2015/006378
Authority: WO
Inventors: 김승국; 윤명석; 원보령
Original assignee: 코스맥스 주식회사
Priority date: 2014-07-23
Filing date: 2015-06-23
Publication date: 2016-01-28
Also published as: KR101645440B1; KR20160012261A; CN105473200A

Abstract

The present invention relates to a hydrogel composition using a phase inversion temperature (PIT) emulsification process and to a production method for same. More specifically, the invention relates to a method wherein a water-based moiety comprising a water-soluble gelling polymer, purified water, a polyhydric alcohol and other additives is heated/stirred at between 60 and 100°C and, in a separate container, an oil-based moiety comprising a nonionic surfactant and an oily skin-softening agent is heated to between 60 and 95°C, and then the water-based moiety and the oil-based moiety are mixed and cooled to a temperature range at which the water-based moiety gells, namely between 60 and 80°C, and at the same time a PIT emulsion is stably impregnated into the gelled article, cooling takes place via a cooler, and a hydrogel is moulded. The present invention makes it possible to achieve more effective skin penetration of active ingredients in the nano-emulsion state, and thus to enhance the effects thereof, by using the PIT emulsification method to make it easier to include oil fractions in hydrogels in which it has previously been difficult to include oil fractions.

Description

【Specification】

[Name of invention]

Method for producing a hydrogel mask comprising a large amount of oil and excellent skin improvement effect and the hydrogel composition prepared through this

Technical Field

The present invention relates to a method for producing a hydrogel and a hydrogel composition prepared through the same, and more particularly, to a method for preparing a hydrogel composition through a phase inversion temperature (PIT) emulsification process and a hydrogel composition prepared through the same. It is about.

Background Art

Increasingly, modern people are suffering from severe skin damage caused by contaminated external environment, stress in daily life, and increasing use of makeup products. To overcome this problem, we use various skin care products such as lotions, creams, essences, and dermatology treatments. However, the use of general skin care products has a limitation of skin penetration due to the nature of the skin tissue, it is difficult to expect immediate skin improvement. This leads to relatively dangerous procedures such as expensive dermatological treatments and drug treatments. Therefore, there is a need for a basic cosmetic that is effective and relatively safe and inexpensive skin penetration.

In recent years, the development and consumption of mask sheets to which various types of sheets are applied is active. This is because it is advantageous that the sheet is relatively inexpensive while effectively increasing the skin absorption of the contents. In addition to the general sheet type, the range of hydrogels, biocells and the like is also expanding. Among them, the grand field of hydrogel is various. In addition to cosmetics, it is widely applied in skin care and medical fields. Most hydrogels maintain the gel state and regulate the release of drugs contained in the hydrogel as a support to the skin slowly. It is possible to use. As a core component of the conventional hydrogel, various gelling polymers having a function of forming and maintaining a gel are mainly used. Many of the hydrogel mask sheets developed in the past were mostly composed of water-soluble components, and even if the oil-soluble components were formulated, the level of the use of the suspension for the purpose of differentiation or a slight feeling of improvement was improved. In addition, when a large amount of useful components are formulated, the useful components are separated, viscoelasticity is lowered, and the adhesion of the skin is lowered.

In order to facilitate skin penetration into the basic cosmetics, the smaller the particle size of the cosmetic is advantageous. Forms of cosmetics can be divided into solubilization and emulsification largely, there are some problems when applied to the hydrogel formulation. In the case of the solubilization type, most of the composition is composed of water-soluble components, so it is difficult to penetrate the outermost layer of skin tissue composed of the sebaceous membrane, and it is not easy to provide oil required by the skin. In the case of emulsification type, it can contain a large amount of oil, so that it can give a good nutrition to the skin, but the particle size is relatively large so that it is not easy to absorb the skin and stable loading inside the hydrogel. There are technical problems such as problems of gel formation and formulation instability in use. In order to overcome these formulation limitations, cosmetics using various methods and materials, such as liposomes, have been developed, but still remain difficult in view of overcoming cost limitations and safe skin application.

Phase inversion temperature emulsi fying system (PIT) emulsification is called the phase-in-phase emulsification system, and when the temperature rises, the degree of hydration of the non-ionic surfactant hydrophilic part decreases, and HLB (hydrophi lic l ipophi lic balance) is used. Emulsification method. In general, the surfactant is a hydrophilic and lipophilic balance in the aqueous solution at a specific temperature, which is called the phase inversion temperature of the surfactant. At the phase temperature, the curvature of water in the hydrophilic part changes from positive to negative, and the association number of the surfactant becomes infinite. In this case, the surfactant phase coexists with the oil phase and the water phase and exists in a transparent gel state as a bi-cont inuous phase. E: how to get the emulsion. This method is a new technology that makes it possible to produce fine nanoemulsion dogs easily only by the composition of a surfactant, without having to pass through the reaction chamber under high pressure or strong dispersion that consumes a lot of energy. When emulsifying common oil

Levels of emulsions are reaching large particles. On the contrary, when the PIT emulsification system is used, it is not difficult to obtain a nano-sized fine emulsion, thereby making it possible to effectively produce excellent contents. In PIT emulsification, W / 0 emulsification phase is formed by increasing activity of hydrophobic group which is an alkyl chain in the range of 80 ~ 951, and bicontiguous phase appears in the range of 61 ~ 69 ^° C. You can get status. As a general molding equipment, there is a limit to quenching high temperature contents uniformly at all times and the cost burden is high. However, it was confirmed that this can be done by utilizing the conditions of quenching through the shell during the forming process of the hydrogel mask.

Korean Patent No. 10-1240254 relates to a hydrogel sheet mast and a method for preparing the same, and comprises a small amount of an encapsulated effective ingredient separately prepared by a phase-transfer emulsification method during the preparation of the hydrogel to prepare a hydrogel sheet mast. It describes a method for improving the moisturizing power and skin flexibility by depositing a small amount on the outside of the hydrogel, but the present invention maximizes the skin efficacy as well as technical value by gelling the entire hydrogel composition using the PIT emulsification method. In general, the manufacturing process of the hydrogel is accompanied by a heating process of 90 ^° C or more, so as to simply add the ingredients encapsulated by the phase-transfer emulsification method during weeding, as described in the registered patent (10-1240254) capsules by high temperature conditions The stability of the chip may be broken or deformed, making it difficult to expect the actual effect. The phase transition emulsification method is a generic term for all emulsification methods that have a form that is changed during manufacture from oil-in-water (0 / W) to water-in-oil (W / 0) or water-in-water (W / 0) to oil-in-water (0 / W). I say that.

In the technique used in the present invention, the PIT emulsion was manufactured by the PIT emulsification method. In particular, the PIT emulsion is sensitive to external temperature since the PIT emulsion is made by an emulsification method using a specific temperature range. Therefore, stable emulsion can be formed through proper temperature conditions and stable prescription design. Accordingly, the present inventors have diligently studied to overcome the problems of the prior art, the hydrogel manufacturing method through the phase inversion temperature (PIT) emulsification process, containing the oil through the PIT method in the hydrogel was difficult to contain oil By facilitating easy to penetrate the skin of the active ingredient in the nano-emulsion state, it was confirmed that the effect can be further improved, and completed the present invention.

Prior Art Documents

[Patent literature]

(Patent Document 0001) K 10-1240254 Β

[Detailed Description of the Invention]

[Technical problem]

Therefore, the main object of the present invention is to facilitate the incorporation of oil through the PIT method in the hydrogel, which was difficult to contain oil, thereby facilitating the skin inversion temperature (PIT) emulsification process of the active ingredient in the nano-emulsion state. It is to provide a method for producing a hydrogel through.

Another object of the present invention is to provide a hydrogel composition prepared using a hydrogel manufacturing method through the phase inversion temperature (PIT) emulsification process.

【Technical Solution】

It provides a method for producing a hydrogel (Hydrogel) composition through a phase inversion temperature (PIT) emulsification process comprising the following steps.

a) warming / stirring the aqueous phase containing water-soluble gelling polymer, purified water, polyhydric alcohol and other additives in a separate container at 60 to 100 ° C .;

b) preparing a PIT emulsion by heating / stirring the oil phase including the nonionic surfactant and the oily skin softener in a separate container at 60 to 95 ^° C .; c) injecting the PIT emulsion of b) into the gelation of a), cooling to 60 to 80 ^° C. and impregnating the PIT emulsion into the gelation; And

d) engraving the hydrogel through granulation and then molding.

The term 'impregnation' of the present invention refers to the inclusion of a PIT emulsion between the network structure of the gelled product.

The term 'aqueous portion' of the present invention is generally referred to as an aqueous portion composed only of components dissolved in water at the time of manufacture. The term 'oil phase' of the present invention is generally referred to as an oil phase portion composed only of components dissolved in oil. However, in the present invention, the water phase portion is 50 to 60% by weight of the purified water included in the water phase portion, including more than 5 to 10% by weight of the content of purified water included in the oil phase portion of the present invention, respectively the water phase portion and the oil phase portion It was said. In addition, the water phase part of this invention is a name of the manufacturing part which mixes purified water, a water-soluble gelling polymer, and polyhydric alcohol, and an oil phase part is a name of the manufacturing part which produces 0 / W emulsion dog by PIT emulsification.

The PIT nanoemulsion used to impregnate oil inside hydrogels having a gel network structure in the present invention is a great discovery. When the common emulsion was impregnated into the hydrogel, the strength of the gel was weakened and the loading itself was impossible. However, the PIT nano emulsion was able to impregnate the inside of the hydrogel, and it was confirmed that the superior efficacy effect can be obtained by the successful completion of the present invention. Because of the possibility of impregnation inside the hydrogel, the characteristic feature highlighted in the present invention is not possible by simple blending after forming the hydrogel, but the temperature at which the water-soluble gelling polymer and the aqueous phase are mixed to gel (60 to 10 CTC). After gelling and PIT emulsion are prepared by heating / stirring at a temperature (60 to 95 ° C.) to form a PIT emulsion at the oil phase and the oil phase, the gel phase and the PIT emulsion are mixed to form a PIT emulsion. PIT emulsions are stably impregnated in the gelation while cooling to a temperature range of 60 to 80 ^° C. PIT emulsions are stably present in the gelled network structure, and the PIT emulsions stably do not lose their original state. Emulsion can be prepared (in the present invention, the 'hydrogel composition of the entire PIT emulsification The 'says Expressed). This hydrogel manufacturing process is the first found in the present invention, and this characteristic part has made it possible to realize the actual hydrogel to industrialization.

In more detail, in case of PIT emulsification, it becomes phase change by W0 emulsification above 95 ° C, and it is easily impregnated into high road gel because bi-continuous layer is formed in the range of 60 ~ 85 ^° C during the slow cooling process. It was found possible. Only in this process was it possible to impregnate the nanoemulsion into the hydrogel, it was not possible to impregnate the oil into the hydrogel in the case of not blending with the general emulsion if not.

In the present invention, the polyhydric alcohol in the step a) may be used any polyhydric acid conventionally used, preferably glycerin, butylene glycol, dipropylene glycol, propylene glycol, nucleic acid diol, 1 , 2-hexanediol, 1,2-pentanedi is characterized in that at least one selected from the group consisting of propanediol and 1,2-octanedi. In the present invention, the other additive in step a) may include any other additives conventionally added to make a hydrogel, preferably methylparaffin, propylparaben, phenoxyethanol glyceryl caprylate, and ethylsilyl glycerin It is characterized in that at least one selected from the group consisting of skin conditioning agent consisting of caprylic / capric glycerides and natural extracts.

In the present invention, the nonionic surfactant in step b) may be any nonionic surfactant conventionally used, preferably glyceryl monostearate, cetes 10-30, ceteares 10-30 and ste And at least one selected from the group consisting of Ares 10 30.

In general, PIT emulsions can be made under the use of nonionic surfactants. According to an embodiment of the present invention, hydrogels prepared by the general emulsification method do not form gels properly, even though nonionic surfactants are used. It was confirmed. As a result of this, in the case of the hydrogel containing the nonionic surfactant prepared by the PIT emulsification method, the emulsified particle size is large. It can be seen that it is possible to prepare a stable hydrogel that is formed and does not cause high cloudiness or breakage (see Comparative Example 1-2, Fig. 9).

In the present invention, the oily skin softener in step b) is characterized in that at least one selected from the group consisting of hydrocarbon-based oil, silicone-based oil, ester-based oil and natural oil. Hydrocarbon oils include Mineral Oil, Isododecane and Squalane, and silicone oils may be selected from Dimethicone, Cyclopentasi loxane and Trisi loxane. In addition, esters include Octyldodecyl Myristate, Di isostearyl Malate, Isopropyl Myristate, and natural oils are Macadamia nut oi l and Sunf lower oi l. Ol ive oi l may be selected from, but is not limited thereto.

In the present invention, the PIT emulsion in step c) is characterized in that it has an average particle size of 100 ~ 500nm.

In the present invention, in the step a), the water-soluble polymer is cellulose, konjac, locust bean gum, carob bean gum, alginate, chitosan, starch, pectin, allyl, guar gum, mannan, poloronig arabic gum, flu Ran, collagen, gellan gum, xanthan gum, carrageenan, sclerotium gum and agar is characterized in that at least one selected from the group consisting of.

According to the embodiment of the present invention, when the hydrogel was prepared by changing the type and content of the water-soluble gelling polymer and oil, there was a slight difference in suspension, but it was confirmed that the hydrogel of the emulsion type was well made. From these results, it can be seen that a stable hydrogel can be prepared through the PIT emulsification process even using the water-soluble gelling polymer and oil (skin softener) shown in the present invention (Example 2-3, FIG. 3-6).

According to another aspect of the present invention, the present invention provides a hydrogel composition prepared according to the above production method.

According to the experimental example of the present invention, the hydrogel composition prepared by applying the PIT emulsification method is compared with the particles of the hydrogel composition prepared by the general emulsification method, whereas the particles prepared by the general emulsification method have a unit size. To PIT Emulsification The prepared particles were confirmed to have a ran unit size. As a result, when the PIT emulsification method is applied to the hydrogel composition, it means that the composition prepared in the nano size was able to more effectively help the absorption of the keratin of the skin and maximize the effect (see Experimental Example 1 and FIG. 10). ).

According to the experimental example of the present invention, as a result of confirming the feeling of use, stimulation test and moisturizing power, test of moisture improvement, it was confirmed that the hydrogel composition of the present invention is superior to the control. As a result, the hydrogel composition prepared by the PIT emulsification method can provide a better effect than the hydrogel composition prepared by the conventional general emulsification method, and these compositions are prepared together in the form of a mask sheet that adheres to the skin. In this case, it can be seen that the effect can be maximized (see Experimental Example 2-3 and FIGS. 11-13).

In the present invention, the composition contains from 0.1 to 10% by weight of gelling polymer, 0.1 to 30% by weight of polyhydric alcohol, 0.1 to 20% by weight of nonionic surfactant, and 0.1 to 30% by weight of skin softener, based on the total weight of the composition. It features.

If the content of the skin softener (oil) is out of the above range, it does not feel the effect when less than 0.1 weight ¾ »and the gel breakage occurs when more than 30% by weight is possible to form a hydrogel having a commodity value. Even in the case of the water-soluble gelling polymer, if it is out of the above range, it is difficult to mold in a gel state if less than 0.1 weight ¾>, and if it is more than 10% by weight, the molding is difficult due to the high viscosity. In addition, in the case of polyhydric alcohol, the elasticity of the gel is lowered when less than 0.1 weight ¾, and the increase in effect is ineffective because the increase is more than 30% by weight. In the case of non-unsaturable surfactants, when the content is 0.1 wt% or less or 20 wt% or more, problems may occur in the formation of suitable emulsified particles and stabilization of the formulation.

In the present invention, the composition is characterized in that the formulation of the mask sheet form.

Advantageous Effects

Hydrogel composition using the PIT emulsification method according to the invention is water and By providing oil at the same time, it can satisfy the nutrition and moisture of the skin at the same time, and can be manufactured in a small particle size simply without special manufacturing equipment, thereby making an economical and effective hydrogel.

[Brief Description of Drawings]

1 and 2 is a view showing the form of the hydrogel prepared according to the preparation method of Example 1 of the present invention.

3 and 4 is a view showing the form of the hydrogel prepared according to the preparation method of the present invention Example 2.

5 and 6 are views showing the form of the hydrogel prepared according to the preparation method of the present invention Example 3.

7 and 8 are views showing the form of the hydrogel prepared according to the preparation method of Comparative Example 1 of the present invention.

9 is a view showing the form of the hydrogel prepared according to the preparation method of Comparative Example 2 of the present invention.

FIG. 10 is a view showing the results of particle size comparison between the general emulsification method and the PIT emulsification method of Experimental Example 1 of the present invention. FIG. .

Figure 11 is a view showing the form of the hydrogel prepared according to the preparation method of Experimental Example 3 of the present invention (from the left control, macadam i aoi, dimethicone (6cs), octyldodecyl myristate).

12 and 13 are views showing the results of moisturizing power and moisture improvement test of the hydrogel prepared according to the preparation method of Experimental Example 3.

14 is a view showing the form of the hydrogel prepared according to the preparation method of Example 3, showing the results of Experimental Example 4.

15 is a view showing the form of the hydrogel prepared according to the preparation method of Example 2, showing the results of Experimental Example 4 (from the left control, macadamia oi l, dimethicone, octyldodecyl myristate). [Form for implementation of invention]

Hereinafter, the present invention will be described in more detail with reference to Examples. Since these examples are only for illustrating the present invention, the scope of the present invention is not to be construed as being limited by these examples. Example 1 Preparation of Hydrogel Through PIT Emulsification Process

It was prepared as follows in the composition of Table 1.

To separate oil melting vessel Mineral oi l, nonionic surfactant of Ceteth-20, and Steareth-20, and Glyceryl Stearate and Cetearyl Alcohol, In the preservative and then dissolved by heating at 70 ~ 85 ^° C In a separate heating the purified water 0 Prepare PIT emulsions in the form of / W. Here, water-soluble gelled polymer, polyhydric alcohol, and other additive partial oligomers heated / dissolved in a separate aqueous phase dissolving tank are added thereto, and the mixture is stirred well. Then, after the PIT emulsion is added to the aqueous dissolution tank, it is angled ^at 60 ~ 80 ^° C and impregnated the PIT emulsion into the gel (water phase). When the contents manufacturing is completed, the contents are discharged and gelated by cooling the contents using a cooler. In the present invention, the key point is to design the preparation method to be consistent with the PIT production temperature and the dissolution temperature of the hydrogel. More specifically, the temperature at which the composition of the aqueous phase portion shown in Table 1 is dissolved is in the range of 70 ~ 90 ^° C., in order to encapsulate the nanoemulsion inside the hydrogel, the preparation silver of the PIT nanoemulsion should be the same. In the case of PIT composition shown in Figure 3, the PIT formation temperature was found to appear selectively in the range of 70 ~ 85 ^° C. On the basis of this theory, it was found that very fine nanoemulsion dogs were packed inside the hydrogel when the hydrogel was prepared. In this case, the hydrogel did not linger and was able to develop a high quality hydrogel that was elastic and moist. Table 1

Water content

Water 62.6

Xanthan Gum 0.3

CARRAGEENAN 0.4

Gellan gum 0.6

Glycerin 1 5

Oil phase part (PIT manufacturing part) content

Mineral oil 7.0

Ceteth-20 1

Steareth-20 1

Glyceryl Stearate 1

Cetearyl Alcohol 0.5

Phenoxyethanol 0.5

Water 10

CaCI ₂ <0.1 As a result, as shown in Figure 1 and 2, it can be seen that the milky thin, elastic formulation is completed. Example 2: Preparation of Hydrogel through PIT Emulsification Process According to Kind and Content of Water-Soluble Gelling Polymer

It was prepared in the same manner as in Preparation Example 1 in Table 2 and the composition.

Table 2

As a result, as shown in Figures 3 and 4, it can be seen that the milky thin, elastic formulation is completed. Example 3: Preparation of hydrogel through PIT emulsification process according to the type of water-soluble gelling polymer, the type of oil and the content of oil phase

To the composition of Table 3 was prepared in the same manner as in Example 1.

[Table 3]

As a result, as shown in Figures 5 and 6 as the type of oil and the content of the oil portion increases the suspension degree can be confirmed that the hydrogel of the emulsion type is well made. Comparative Example 1: Preparation of a hydrogel through the PIT emulsification process containing no oil and no silver surfactant

The composition of Example 1 was prepared in the same manner as in Preparation Example 1 except for the oil phase part (oil nonionic surfactant, Cetearyl Alcohol).

As a result, it can be seen that the hydrogel of the transparent form is made as shown in Figures 7 and 8. Comparative Example 2: Preparation of Hydrogel by General Emulsification

It was carried out in the same composition as in Example 1, but prepared by the general emulsification method, not the PIT emulsification method. As shown in the composition of Table 4, the water-soluble gelling polymer and polyalcohol were dissolved in the aqueous phase and then emulsified by heating / dissolving the non-silver surfactant and the oil-based skin softener in a separate oil phase. When the contents manufacturing is completed, the contents are discharged and gelated by cooling the contents using a cooler.

[Table 4]

As a result, as shown in Figure 9 it can be confirmed that the emulsified particle size is formed large, the turbidity is high, the gel formation is not properly formed, the phenomenon of breakage occurs. Experimental Example 1 Comparison of Particle Sizes between General Emulsification and PIT Emulsification

In the present invention, the oil inside the hydrogel having a gel network structure The effect of oil particles on impregnation was tested. This experiment suggests some of the results of the experiment to suggest more empirical part of the present invention.

However, this result does not correspond to all of the present invention, it is intended to reveal some comparison results.

The emulsifier using the PIT emulsification method was prepared in Example 1, and the particle size was measured. On the other hand, the emulsifier used in the emulsion system using the general emulsification method is commonly used a combination of polysorbate -60 and glyceryl monostearate as the most commonly used surfactant (Table 5), the production method It proceeded similarly to Example 1. In addition, the concentration was tested to the same concentration as the total concentration of the surfactant using the PIT emulsification method.

Table 5

As a result, as shown in FIG. 10, in the emulsion system using the PIT emulsification method, when the mineral oil concentration was 3¾, the average particle diameter was 87 nm, and when the average particle size was 5¾, the average particle diameter was 98 nm and 7%, and the average particle diameter was 105 nm. It can be seen that the distribution before and after lOOnm.

On the other hand, in the emulsion system using the general emulsification method, when the mineral oil concentration was 3%, the average particle diameter was 5.2 μ ηι, and when the average particle diameter was 59.6, the average particle diameter was 9.6 μηι and the average particle diameter was 7 · 5. From μ ηι, it can be seen that very large particles are formed in the range of 5 to 10 μ η.

This result was additionally found to be due to a large effect on the stability of the oil packed inside the hydrogel. The oil using the general emulsification method was very poor when it was impregnated into the hydrogel, and the strength of the gel was also weakened, causing easy breakage. However, the PIT nano emulsions were loaded stably in the hydrogel, and the stability and the strength of the gel were maintained intact, and the basic performance was found to double.

In view of these results, the skin evaluation of hydrogels was expected to be superior to the superiority, and further experiments on skin evaluation were performed. Hereinafter, the present invention will be described by the following examples. However, these are not limited to the scope of the present invention by these as an embodiment of the present invention. Experimental Example 2: Feeling and skin irritation test

Using Example 1 and Comparative Example 1, and attached to the face for 20 minutes for each of 15 men and women each 30 minutes, the feeling and stimulation test was carried out. As a result, as shown in Table 6, Example 1 can be seen that compared to Comparative Example 1 in the overall evaluation items such as skin moisturizing and flexibility, stimulation. In particular, much improved improvement was found in skin moisturizing and suppleness, which contained oils with similar levels of oil content as commonly produced emulsion dogs. Expected to increase flexibility

Table 6

Evaluation criteria: Very good (5 points) / Excellent (4 points) / Normal (3 points) / Poor (2 points) / Very poor (1 point) Experimental Example 3: Moisturizing and moisture improvement test

Based on the results confirmed through Experimental Example 2, the test was conducted to improve the moisturizing power and moisture to obtain more objective data. The experiment was carried out after the manufacture through the same manufacturing method as in Example 1 only changing the type of oil in the same prescription as in Table 7. As the oil, the same vegetable oil (Macadamia oil), silicone oil (Dimethic e 6cs) and ester oil (Octyldodecyl Myristate) were used in the same amount.

[Table 7]

-Measurement method: After absorbing the product by attaching it to the test area for 30 minutes, measure the moisturizing power every 2 hours, 4 hours, 8 hours before use and immediately after use (30 minutes).

-Analysis of results: Moisturizing power is calculated using the average value measured three times.

Test subjects: 18 healthy adult women and 12 males (average 25 years old)

-Test site: arm (inner forearm, 2 x 2 cm ² )

-Measuring Instrument: Moisture Measurement-Corneometer CM 825

-Test substance: 1. Control hydrogel

2.Macadamia nut oi 1

3.Dimethicone (6CS)

4. Eutanol GM As a result, all four species including Control Hydrogel showed higher skin moisturizing effect up to 8 hours than the non-coating group, and Macadamia nut oil and Eutanol GM showed higher moisturizing effect than Control Hydrogel (FIG. 11 to FIG. 13). Experimental Example 4: Skin delivery test of the emulsion active ingredient

The hydrogel prepared in Example 2 was observed by leaving it exposed to air. As a result, as can be seen in Figures 14 and 15, there is a difference in speed depending on the type of oil, but it can be seen that the impregnated emulsion inside the gel exits the outside of the gel and the gel becomes more transparent. This confirmed that the active ingredient in the hydrogel can be easily eluted from the matrix and transferred to the skin along with the dihydrate.

Claims

[Claims]

[^ Clause 1]

Method for preparing a hydrogel composition through phase inversion temperature (PIT) emulsification process comprising the following steps:

a) warming / stirring the water phase including the water-soluble gelling polymer, purified water, polyhydric alcohol, and the addition additive in a separate container at 60 to 100 ^° C .;

b) preparing a PIT emulsion by heating / stirring the oil phase including the nonionic surfactant and the oily skin softener in a separate container at 60 to 95 ^° C .;

c) injecting the PIT emulsion of b) into the gelation of a), cooling to 60 to 80 ^° C. and impregnating the PIT emulsion into the gelation; And

d) molding after cooling the hydrogel through a cooler.

[Claim 2]

According to claim 1, wherein the polyhydric alcohol in step a) glycerin, butylene glycol, dipropylene glycol, propylene glycol, hexanedi, 1,2- nucleic acid di, 1,2-pentanedi, propane Method for producing a hydrogel composition, characterized in that at least one selected from the group consisting of diol and 1,2-octanediol.

[Claim 3]

The method of claim 1, wherein the other additive in step a) is a group consisting of a skin conditioning agent consisting of methyl paraffin, propyl paraben, phenoxyethanol glyceryl caprylate, ethynyl glycerin, caprylic / capric glyceride and natural extracts Method for producing a hydrogel composition, characterized in that at least one selected from.

[Claim 4]

The method of claim 1, wherein in step b), the nonionic surfactant is glyceryl monostearate, cetes 10-30, ceteares 10-30 and steares 10-30. Process for producing a hydrogel composition, characterized in that at least one selected from the group consisting of.

[Claim 5]

The method of claim 1, wherein the oil-based skin softener in step b) is at least one selected from the group consisting of hydrocarbon-based oils, silicone-based oils, ester-based oils and natural oils.

[Claim 6]

[Claim 2] The method of claim 1, wherein the cit emulsion in step c) has a mean particle size of 100-500 nm.

[Claim 7]

The method of claim 1, wherein in the step a), the water-soluble polymer is cellulose, konjac, locust bean gum, carob bean gum, alginate, chitosan, starch, pectin, allyl, guar gum, mannan, pluronig arabic gum, Method for producing a hydrogel composition, characterized in that at least one selected from the group consisting of pullulan, collagen, gellan gum, xanthan gum, carrageenan, sclerotium gum and agar.

[Claim 8]

Hydrogel composition prepared according to the method of claim 1. [Claim 9]

The composition of claim 8, wherein the composition contains 0.1 to 10% by weight of gelling polymer, 0.1 to 20% by weight of polyhydric alcohol, 0.1 to 20% by weight of nonionic surfactant, and 0.1 to 30% by weight of skin softener. Hydrogel composition. [Claim 10]

The hydrogel composition of claim 8, wherein the composition is in the form of a mask sheet.