TWI709414B - Nano emulsion having a high ceramide content and improved transparency, cosmetic composition containing the same, and preparation method of the same - Google Patents
Nano emulsion having a high ceramide content and improved transparency, cosmetic composition containing the same, and preparation method of the same Download PDFInfo
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Abstract
Description
本發明是有關於一種透明度得到改善的高含量神經醯胺的奈米乳液、含有其的化妝品組成物及其製備方法,更詳細而言,有關於一種按照適當的調配比對神經醯胺、離子性界面活性劑、多元醇及矽酮油進行高壓乳化而製備的高含量神經醯胺的奈米乳液、含有其的化妝品組成物及其製備方法。 The present invention relates to a high-content ceramide nanoemulsion with improved transparency, a cosmetic composition containing the same, and a preparation method thereof. In more detail, it relates to a method for comparing ceramide and ion with an appropriate blending ratio. A high-content ceramide nanoemulsion prepared by high-pressure emulsification of a surfactant, polyol and silicone oil, a cosmetic composition containing the same, and a preparation method thereof.
人體皮膚的表面包括自基底層分化而成熟的角質形成細胞退化而成的角質細胞。這些角質細胞藉由大量存在於角質層的神經醯胺的雙鏈層狀結構而結合,從而保持光滑有彈性的皮膚。 The surface of human skin includes keratinocytes degenerated from mature keratinocytes differentiated from the basal layer. These keratinocytes are combined by the double-stranded layered structure of ceramide, which is abundant in the stratum corneum, so as to maintain smooth and elastic skin.
神經醯胺類具有難溶性,因此需藉由製備成微粒子的型態才能大量提供於化妝品劑型中,然而,此導致劑型的穩定度 下降,與發生凝膠化(Gelation)。若粒子尺寸較小,則粒子間的表面能量較大而引力的作用較大。神經醯胺間的相互作用增大而無法完全分散至油上,因此因略微呈現為水相的神經醯胺間的結合而發生凝膠化。 Ceramides are poorly soluble, so they need to be prepared in the form of microparticles to provide them in a large amount in cosmetic formulations. However, this leads to the stability of the formulation Decrease, and gelation (Gelation) occurs. If the particle size is smaller, the surface energy between the particles is larger and the effect of gravity is larger. The interaction between the ceramides is increased and cannot be completely dispersed on the oil, so the gelation occurs due to the bond between the ceramides which is slightly in the water phase.
為了解決上述問題,應用以如下方式將神經醯胺穩定化的技術:以神經醯胺、硬脂酸及膽固醇等製備顆粒(粒子),於製備乳液時,在最後的步驟添加上述顆粒(粒子)。即,使用以神經醯胺消除流動度的方式實現穩定度的方法。上述神經醯胺是藉由以下步驟製備的堅硬固體:首先,於外部製備使神經醯胺穩定化的顆粒;接著,將上述顆粒分散至乳液。韓國專利申請第2008-0072355號中揭示有利用固相殼的成核劑上的神經醯胺的相關技術。 In order to solve the above-mentioned problems, the technique of stabilizing ceramide in the following way is applied: preparing granules (particles) with ceramide, stearic acid, cholesterol, etc., when preparing an emulsion, adding the aforementioned particles (particles) in the final step . That is, a method of achieving stability in a way that ceramide eliminates fluidity is used. The above-mentioned ceramide is a hard solid prepared by the following steps: firstly, particles stabilizing the ceramide are prepared externally; then, the above-mentioned particles are dispersed into an emulsion. Korean Patent Application No. 2008-0072355 discloses a related technology using ceramide on a nucleating agent of a solid shell.
然而,此種方式亦會因於神經醯胺的膠囊化過程中大量使用膠囊化劑而導致可實際使用於化妝品的含量減少。並且,於使用感方面,作為化妝品組成物的必要成分的糖類或高分子類的膠囊化劑具有破壞化妝品固有的使用感的缺點。 However, this method will also reduce the content of ceramide that can be actually used in cosmetics due to the large amount of encapsulating agent used in the encapsulation process of ceramide. In addition, in terms of the feeling of use, the encapsulating agent of sugar or polymer, which is an essential component of the cosmetic composition, has the disadvantage of destroying the inherent feeling of use of the cosmetic.
先前技術文獻包括韓國註冊專利公報第0837558號“包括雙重穩定的神經醯胺奈米膠囊的乳液組成物、其製備方法及利用其的皮膚化妝品組成物”。 The prior art documents include Korean Registered Patent Publication No. 0837558 "Emulsion composition including dual-stable ceramide nanocapsules, its preparation method, and skin cosmetic composition using the same."
對於乾性皮膚人群而言,於皮膚組織中防止水分流失、於皮膚表面發揮異物的屏障功能的神經醯胺因其結構特性而容易於化妝品劑型中結晶化,從而於劑型中含有較高的含量的情形時,產生層分離或析出現象。 For people with dry skin, Ceramide, which prevents moisture loss in skin tissues and exerts a barrier function of foreign bodies on the skin surface, is easy to crystallize in cosmetic formulations due to its structural properties, and therefore contains a higher content of In this case, layer separation or separation phenomenon occurs.
因此,目前化妝品劑型中所含有的神經醯胺通常為2重量%左右,再者,因此種化妝品劑型的透明度明顯下降而亦發生渾濁,故而無法應用於透明劑型的潤膚液類,目前僅限制性地用於製備低黏度的乳液類。並且,於長時間閒置的情形時,劑型的穩定度下降而發生凝膠化。 Therefore, the current ceramide contained in cosmetic formulations is usually about 2% by weight. Moreover, the transparency of this cosmetic formulation is significantly reduced and turbidity also occurs. Therefore, it cannot be applied to transparent formulations of lotions. At present, it is only limited It can be used to prepare low viscosity emulsions. In addition, when left unused for a long time, the stability of the dosage form decreases and gelation occurs.
因此,本發明的目的在於製備一種既以高含量含有神經醯胺,亦可保持透明度的劑型穩定度優異的神經醯胺奈米乳液。 Therefore, the purpose of the present invention is to prepare a ceramide nanoemulsion that contains ceramide in a high content and maintains transparency in a dosage form with excellent stability.
本發明是為了達成上述目的而提出,提供一種包括神經醯胺、離子性界面活性劑、多元醇及乙醇的透明度得到改善的高含量神經醯胺的奈米乳液。上述奈米乳液可更包括矽酮油。此時,上述組成物較佳為含有1重量%至10重量%的神經醯胺、1重量%至1.5重量%的離子性界面活性劑、20重量%至40重量%的多元醇、1重量%至5重量%的乙醇及15重量%至30重量%的矽酮油,以此方式製備的高含量神經醯胺的奈米乳液的粒子尺寸較佳為10nm至30nm。 The present invention is proposed in order to achieve the above-mentioned object, and provides a high-content ceramide nanoemulsion containing ceramide, an ionic surfactant, a polyol, and ethanol with improved transparency. The aforementioned nanoemulsion may further include silicone oil. At this time, the above composition preferably contains 1% to 10% by weight of Ceramide, 1% to 1.5% by weight of ionic surfactant, 20% to 40% by weight of polyol, 1% by weight To 5% by weight of ethanol and 15% to 30% by weight of silicone oil, the particle size of the high-content ceramide nanoemulsion prepared in this way is preferably 10nm to 30nm.
本發明提供一種透明度得到改善的神經醯胺乳液的製 備方法,其特徵在於包括如下步驟:i)混合溶解有神經醯胺的油相溶液與溶解有界面活性劑的水相溶液而製備一次油分散液的步驟;ii)向上述一次油分散液加入矽酮油及乙醇而製備二次油分散液的步驟;iii)將上述二次油分散液高速乳化而製備一次乳化液的步驟;以及iv)將上述一次乳化液高壓乳化而製備二次乳化液的步驟;且於上述i)步驟中,油相溶液的溶劑為多元醇,水相溶液的界面活性劑為離子性界面活性劑。此時,上述iii)步驟的高速乳化可利用均質攪拌機(Homomixer)以5000rpm至10000rpm進行1分鐘至20分鐘的乳化,上述iv)步驟的高壓乳化可利用微射流均質機(Microfluidizer)以12000psi至18000psi進行1次循環(cycle)至5次循環的乳化。 The invention provides a preparation of ceramide emulsion with improved transparency The preparation method is characterized in that it comprises the following steps: i) mixing the oil phase solution in which ceramide is dissolved and the water phase solution in which the surfactant is dissolved to prepare a primary oil dispersion; ii) adding to the above primary oil dispersion The step of preparing a secondary oil dispersion with silicone oil and ethanol; iii) the step of emulsifying the above-mentioned secondary oil dispersion at a high speed to prepare a primary emulsion; and iv) the step of emulsifying the above-mentioned primary emulsion at high pressure to prepare a secondary emulsion And in step i) above, the solvent of the oil phase solution is a polyol, and the surfactant of the water phase solution is an ionic surfactant. At this time, the high-speed emulsification in step iii) can be emulsified at 5000 rpm to 10000 rpm for 1 minute to 20 minutes using a homomixer, and the high-pressure emulsification in step iv) can be emulsified at 12000 psi to 18000 psi using a Microfluidizer. Perform emulsification from 1 cycle to 5 cycles.
根據本發明的透明度得到改善的高含量神經醯胺的奈米乳液,可藉由製備10nm至30nm的奈米尺寸的乳化粒子而以最高達10重量%的高含量含有神經醯胺,可防止凝膠化而於應用於化妝品時提高穩定度。並且,因透明度得到改善而可將先前限制性地應用於乳液型化妝品中的神經醯胺廣泛地應用於透明的潤膚液類或乳霜類。 The high-content ceramide nanoemulsion with improved transparency according to the present invention can contain ceramide at a high content of up to 10% by weight by preparing 10nm to 30nm nano-sized emulsified particles, which can prevent coagulation. Gelation to improve stability when applied to cosmetics. In addition, since the transparency has been improved, ceramide, which was previously restrictedly used in emulsion cosmetics, can be widely used in transparent lotions or creams.
s10、s20、s30、s40:步驟 s10, s20, s30, s40: steps
圖1是對本發明的一實施例的高含量神經醯胺的奈米乳液的 透明度進行相對比較的圖像。 Figure 1 is a comparison of the high-content ceramide nanoemulsion of an embodiment of the present invention The transparency of the image is relatively compared.
圖2是本發明的透明度得到改善的高含量神經醯胺的奈米乳液的製備方法的流程圖。 2 is a flow chart of the preparation method of the high-content ceramide nanoemulsion with improved transparency of the present invention.
本發明是有關於一種透明度得到改善的高含量神經醯胺的奈米乳液、含有其的化妝品組成物及其製備方法,更詳細而言,有關於一種包括神經醯胺、離子性界面活性劑及多元醇,按照適當的調配比更添加矽酮油而進行高壓乳化來製備的高含量神經醯胺的奈米乳液、含有其的化妝品組成物及其製備方法。以下,詳細地對本發明進行說明。 The present invention relates to a high-content ceramide nanoemulsion with improved transparency, a cosmetic composition containing the same, and a preparation method thereof. More specifically, it relates to a ceramide, ionic surfactant, and Polyol is prepared by adding silicone oil according to an appropriate mixing ratio and high-pressure emulsification to prepare a high-content ceramide nanoemulsion, a cosmetic composition containing the same, and a preparation method thereof. Hereinafter, the present invention will be described in detail.
上述神經醯胺較佳為相對於乳液的整體重量含有1重量%至10重量%。於小於1重量%的情形時,在應用於化妝品劑型時,效果甚微,於大於10重量%的情形時,引發凝膠化而劑型穩定度下降。 The ceramide is preferably contained in 1% to 10% by weight relative to the total weight of the emulsion. In the case of less than 1% by weight, the effect is very small when applied to cosmetic formulations, and in the case of more than 10% by weight, gelation is initiated and the stability of the dosage form decreases.
上述離子性界面活性劑可單獨使用選自由鯨蠟醇磷酸酯鉀(Potassium Cetyl Phosphate)、硬脂醯穀胺酸鈉(Sodium Stearoyl Glutamate)、甘油硬脂酸酯檸檬酸酯(Glyceryl Stearate Citrate)、二硬脂基二甲基氯化銨(Distearyl Dimonium Chloride)、β支鏈型單十六烷基(Hexadecyl)磷酸精胺酸所構成的族群中的一種、或選擇兩種以上而使用,更佳為可使用鯨蠟醇磷酸酯鉀(Potassium Cetyl Phosphate)或硬脂醯穀胺酸鈉 (Sodium Stearoyl Glutamate)。 The above-mentioned ionic surfactant can be used alone selected from the group consisting of Potassium Cetyl Phosphate, Sodium Stearoyl Glutamate, Glyceryl Stearate Citrate, Distearyl Dimonium Chloride (Distearyl Dimonium Chloride), β-branched monohexadecyl (Hexadecyl) arginine phosphate group consisting of one, or two or more selected and used, more preferably Potassium Cetyl Phosphate or sodium stearyl glutamate can be used (Sodium Stearoyl Glutamate).
此種離子性界面活性劑較佳為相對於乳液的整體重量含有1重量%至1.5重量%。於小於1重量%的情形時,在應用於化妝品劑型時,穩定化效果甚微而發生凝膠化,於大於1.5重量%的情形時,對皮膚產生刺激,因此較佳為於上述範圍內適當地調節。 It is preferable that such an ionic surfactant contains 1 weight% to 1.5 weight% with respect to the whole weight of an emulsion. When it is less than 1% by weight, the stabilizing effect is very small and gelation occurs when applied to cosmetic formulations. When it is more than 1.5% by weight, it will cause skin irritation, so it is preferably within the above range.地调。 Ground adjustment.
上述多元醇用以調節劑型的折射率而提高透明度、保濕力,可單獨使用選自由甘油(Glycerine)、1,3-丁二醇(1,3-Butylene Glycol:BG)、丙二醇(Propylene Glycol:PG)及二丙二醇(Dipropylene Glycol:DPG)所構成的族群中的一種、或選擇兩種以上而使用,較佳為相對於乳液的整體重量含有20重量%至40重量%範圍內的多元醇。於小於20重量%的情形時,高含量神經醯胺的可溶化受限,於大於40重量%的情形時,存在皮膚的使用感下降的問題。 The above polyols are used to adjust the refractive index of the dosage form to improve transparency and moisturizing power. It can be used alone selected from glycerine (Glycerine), 1,3-butylene glycol (1,3-Butylene Glycol: BG), and propylene glycol (Propylene Glycol: PG) and dipropylene glycol (Dipropylene Glycol: DPG) constitute one, or select two or more of them to be used. Preferably, the polyol is contained in the range of 20% to 40% by weight relative to the total weight of the emulsion. When it is less than 20% by weight, the solubilization of the high content of ceramide is limited, and when it is more than 40% by weight, there is a problem that the feeling of use of the skin decreases.
上述矽酮油用以代替先前的可形成層狀結構的蠟來調節使用感與濁度,可應用折射率與蠟相似的二甲聚矽氧烷(Dimethicone)類、環戊矽氧烷(Cyclopentasiloxane)等。較佳為相對於乳液的整體重量含有15重量%至30重量%範圍內的此種矽酮油,於小於15重量%的情形時,透明度下降,於大於30重量%的情形時,產生用以使矽酮油乳化的界面活性劑的含量超過適當值的問題。 The above silicone oil is used to replace the previous wax that can form a layered structure to adjust the feeling of use and turbidity. Dimethicone and Cyclopentasiloxane with similar refractive index and wax can be used. )Wait. It is preferable to contain such silicone oil in the range of 15% to 30% by weight relative to the total weight of the emulsion. When it is less than 15% by weight, the transparency decreases, and when it is more than 30% by weight, it is used The problem that the content of the surfactant for emulsifying silicone oil exceeds the appropriate value.
本發明的高含量神經醯胺的奈米乳液的粒子尺寸較佳 為10nm至30nm。其原因在於,於小於10nm的情形時,難以進行製備製程,於大於30nm的情形時,透明度下降、引發凝膠化而劑型穩定化下降。 The particle size of the high-content ceramide nanoemulsion of the present invention is better It is 10nm to 30nm. The reason is that when it is less than 10 nm, it is difficult to perform the preparation process, and when it is greater than 30 nm, the transparency decreases, gelation is initiated, and the stability of the dosage form decreases.
另一方面,透明度得到改善的高含量神經醯胺的奈米乳液可藉由稀釋或添加增黏劑而作為化妝品組成物,上述化妝品組成物能夠以潤膚液、潤膚乳、乳霜、精華液、精華素、粉、粉底、噴霧、面膜、貼片面膜、睡眠面膜、水洗面膜及撕拉式面膜中的任一形態劑型化。 On the other hand, a high-content ceramide nanoemulsion with improved transparency can be used as a cosmetic composition by diluting or adding a thickening agent. The above cosmetic composition can be used as a lotion, lotion, cream, and essence. Any form of liquid, essence, powder, foundation, spray, mask, patch mask, sleeping mask, wash mask and tear-off mask can be formulated.
添加作上述化妝品組成物的增黏劑可使用公知的增黏劑,可單獨使用選自由糊精棕櫚酸酯(Dextrin Palmitate)、糊精棕櫚酸酯/乙基己酸酯(Dextrin Palmitate/Ethylhexanoate)、環戊矽氧烷(Cyclopentasiloxane)及PEG/PPG-19/19二甲聚矽氧烷(PEG/PPG-19/19 Dimethicone)、聚矽氧烷-11(Polysilicone-11)、二甲聚矽氧烷共聚物(Dimethicone Crosspolymer)、季銨鹽-18矽酸鎂鋰(Quaternium-18 Hectorite)、司拉氯銨水輝石(Stearalkonium Hectorite)及二硬脂基二甲基胺鋰皂石(Disteardimonium Hectorite)所構成的族群中的一種、或選擇兩種以上而使用。 As the tackifier added as the above cosmetic composition, a known tackifier can be used, and it can be used alone selected from Dextrin Palmitate and Dextrin Palmitate/Ethylhexanoate. , Cyclopentasiloxane and PEG/PPG-19/19 Dimethicone (PEG/PPG-19/19 Dimethicone), Polysilicone-11 (Polysilicone-11), Dimethicone Dimethicone Crosspolymer, Quaternium-18 Magnesium Lithium Silicate (Quaternium-18 Hectorite), Stearalkonium Hectorite and Disteardimonium Hectorite ) Is used in one or two or more groups.
進而,本發明提供一種透明度得到改善的神經醯胺乳液的製備方法。圖2是一種透明度得到改善的神經醯胺乳液的製備方法的流程圖。請參照圖2,透明度得到改善的神經醯胺乳液的製備方法包括:i)混合溶解有神經醯胺的油相溶液與溶解有界 面活性劑的水相溶液而製備一次油分散液的步驟(步驟s10);ii)向上述一次油分散液加入矽酮油及乙醇而製備二次油分散液的步驟(步驟s20);iii)將上述二次油分散液高速乳化而製備一次乳化液的步驟(步驟s30);以及iv)將上述一次乳化液高壓乳化而製備二次乳化液的步驟(步驟s40);且於上述步驟s10中,油相溶液的溶劑為多元醇,水相溶液的界面活性劑為離子性界面活性劑。 Furthermore, the present invention provides a method for preparing a ceramide emulsion with improved transparency. Fig. 2 is a flow chart of a preparation method of ceramide emulsion with improved transparency. Referring to Figure 2, the preparation method of the ceramide emulsion with improved transparency includes: i) mixing the oil phase solution in which ceramide is dissolved with the dissolved boundary The step of preparing a primary oil dispersion from the aqueous phase solution of the surfactant (step s10); ii) the step of preparing a secondary oil dispersion by adding silicone oil and ethanol to the above-mentioned primary oil dispersion (step s20); iii) The step of emulsifying the above-mentioned secondary oil dispersion at high speed to prepare a primary emulsion (step s30); and iv) the step of emulsifying the above-mentioned primary emulsion at high pressure to prepare a secondary emulsion (step s40); and in the above step s10 , The solvent of the oil phase solution is a polyol, and the surfactant of the water phase solution is an ionic surfactant.
此時,上述步驟s30的高速乳化可利用均質攪拌機以5000rpm至10000rpm進行1分鐘至20分鐘的乳化,上述步驟s40的高壓乳化可利用微射流均質機以12000psi至18000psi進行1次循環至5次循環的乳化。 At this time, the high-speed emulsification in the above step s30 can be emulsified with a homomixer at 5000rpm to 10000rpm for 1 minute to 20 minutes, and the high-pressure emulsification in the step s40 can be carried out from 1 to 5 cycles with a microjet homogenizer at 12000psi to 18000psi Of emulsification.
根據組成比製備高含量神經醯胺的奈米乳液 Preparation of nano emulsion with high content of ceramide according to the composition ratio
使用Ceramide-102(羥丙基雙月桂醯胺MEA(Hydroxypropyl Bislauramide MEA))、Ceramide-104(羥丙基雙棕櫚醯胺MEA(Hydroxypropyl Bispalmitamide MEA))兩種作為神經醯胺,使用Eumulgin SG(硬脂醯穀胺酸鈉(Sodium Stearoyl Glutamate))作為離子性界面活性劑,使用甘油(Glycerine)作為多元醇,使用二甲聚矽氧烷(Dimethicone)作為矽酮油,按照下述表1的實施例1至實施例6的組成比製備奈米乳液。 Ceramide-102 (Hydroxypropyl Bislauramide MEA (Hydroxypropyl Bislauramide MEA)) and Ceramide-104 (Hydroxypropyl Bispalmitamide MEA) are used as ceramide, and Eumulgin SG (hard Sodium Stearoyl Glutamate (Sodium Stearoyl Glutamate) is used as an ionic surfactant, Glycerine is used as a polyol, and Dimethicone is used as a silicone oil, according to the following table 1 The composition ratio of Example 1 to Example 6 was used to prepare nanoemulsion.
如下所述般實施下述實施例1至實施例6的奈米乳液的製備製程。 The preparation process of the nanoemulsion of the following Examples 1 to 6 was implemented as described below.
步驟1),於向甘油加入Ceramide-102或Ceramide-104後,一面升溫至80℃,一面進行攪拌而進行油分散。 Step 1), after adding Ceramide-102 or Ceramide-104 to glycerin, the temperature is raised to 80°C while stirring to perform oil dispersion.
步驟2),向水中加入Eumulgin SG,一面升溫至80℃,一面進行油分散。 Step 2), add Eumulgin SG to the water, while heating up to 80°C, while dispersing the oil.
步驟3),一面對上述步驟1)的混合物進行均質攪拌,一面緩緩地加入上述步驟2)的混合物。 Step 3), while homogenously stirring the mixture of the above step 1), slowly add the mixture of the above step 2).
步驟4),於確認上述步驟3)的混合物的外觀後,追加加入二甲聚矽氧烷(Dimethicone)與乙醇而以8500rpm進行一次乳化5分鐘。 In step 4), after confirming the appearance of the mixture of the above step 3), dimethicone and ethanol were additionally added, and emulsification was performed once at 8500 rpm for 5 minutes.
步驟5),利用微射流均質機以15000psi對進行上述一次乳化所得的混合物進行3次循環(以500ml基準而進行10分鐘)的乳化。 Step 5), using a micro-jet homogenizer to emulsify the mixture obtained by performing the above-mentioned primary emulsification at 15000 psi for 3 cycles (for 10 minutes on a 500 ml basis).
高含量神經醯胺的奈米乳液的各項測試 Various tests of nano emulsion with high content of ceramide
下述表2是獲取所製備的上述實施例1至實施例6的樣品而對粒子尺寸、穩定度及濁度(Turbidity)等項目進行評價的結果。請參照圖1,其可比較實施例1、實施例5以及實施例6 的相對透明度。4週穩定度測試是於在45℃的溫度下放置4週後,根據是否發生結晶化或層分離而評估穩定度,濁度是於上述實施例1至實施例6的樣品中選擇粒子尺寸滿足10nm至30nm的範圍的實施例1、實施例2、實施例5及實施例6而以測定因懸濁粒子形成的散射度的散射測濁法(Nephelometry)的散射濁度單位(Nephelometry Turbidity Unit:NTU)為基準而表示的結果。 The following Table 2 is the result of obtaining the prepared samples of the aforementioned Examples 1 to 6 and evaluating the items such as particle size, stability, and turbidity. Please refer to Figure 1, which compares Example 1, Example 5 and Example 6 Relative transparency. The 4-week stability test is to evaluate the stability according to whether crystallization or layer separation occurs after being placed at a temperature of 45°C for 4 weeks. The turbidity is selected from the samples of Examples 1 to 6 above. Example 1, Example 2, Example 5, and Example 6 in the range of 10 nm to 30 nm are used to measure the scattering degree formed by suspended particles. The Nephelometry Turbidity Unit (Nephelometry Turbidity Unit: NTU) is the result expressed as a benchmark.
根據上述表2中的測試結果,於兩種神經醯胺中,相較於Ceramide-104,Ceramide-102於相同的組成比下形成更小的奈米乳液粒子。再者,若分別對實施例1及實施例2、實施例4至實施例6進行比較,則因乙醇的含量增加而形成微粒子,但根據實施例6的穩定度測試結果,確認到發生層分離,從而確認到並非只要粒子尺寸較小即可實現較高的穩定度。 According to the test results in Table 2 above, among the two ceramides, compared to Ceramide-104, Ceramide-102 forms smaller nano-emulsion particles at the same composition ratio. Furthermore, comparing Example 1 and Example 2, Example 4 to Example 6 respectively, the increase in ethanol content resulted in the formation of fine particles, but according to the stability test results of Example 6, it was confirmed that layer separation occurred Therefore, it was confirmed that higher stability is not achieved as long as the particle size is small.
根據界面活性劑製備高含量神經醯胺的奈米乳液 Preparation of high-content ceramide nanoemulsion based on surfactants
以下,根據下述表3的實施例7至實施例10,改變界面活性劑的種類而製備奈米乳液。採用Ceramide-104作為神經醯胺,分別加入TA-100(二硬脂基二甲基氯化銨(Distearyl Dimonium Chloride))、Amphisol K(鯨蠟醇磷酸酯鉀(Potassium Cetyl Phosphate))、Dracorin CE(甘油硬脂酸酯檸檬酸酯(Glyceryl Stearate Citrate))、Phopure LC(β支鏈型單十六烷基磷酸精胺酸)四種作為界面活性劑。 Hereinafter, according to Examples 7 to 10 in Table 3 below, a nanoemulsion was prepared by changing the type of surfactant. Use Ceramide-104 as Ceramide, add TA-100 (Distearyl Dimonium Chloride), Amphisol K (Potassium Cetyl Phosphate)), Dracorin CE (Glyceryl Stearate Citrate), Phopure LC (β-branched monohexadecyl arginine phosphate) as surfactants.
下述表3的實施例7至實施例10的奈米乳液的製備製程與上述實施例1至實施例6的奈米乳液的製備方法相同,因此省略其具體說明。 The preparation process of the nanoemulsions of Examples 7 to 10 in Table 3 below is the same as the preparation method of the nanoemulsions of Examples 1 to 6 described above, so the detailed description is omitted.
高含量神經醯胺的奈米乳液的各項測試 Various tests of nano emulsion with high content of ceramide
下述表4的實施例7至實施例10的奈米乳液的各項測試方法與上述實施例1至實施例6的奈米乳液的各項測試方法相同,因此省略其具體說明。可進一步參照圖1,相較於實施例10,可看出所製備的實施例1、實施例5以及實施例6的相對透明度。 The test methods of the nanoemulsions of Examples 7 to 10 in Table 4 below are the same as the test methods of the nanoemulsions of Examples 1 to 6 described above, so detailed descriptions are omitted. With further reference to FIG. 1, compared with Example 10, the relative transparency of the prepared Example 1, Example 5 and Example 6 can be seen.
根據上述表4的測試結果可知,於作為陽離子性界面活性劑的TA-100(實施例7)的情形時,粒子尺寸超過奈米範圍,於使用相對較大的Dracorin CE(實施例9)的情形時,形成較大的粒子尺寸。並且,於Amphisol K(實施例8)的情形時,表現出與Eumulgin SG(實施例1至實施例6)的情形相似的粒子尺寸及穩定度。 According to the test results in Table 4 above, it can be seen that in the case of TA-100 as a cationic surfactant (Example 7), the particle size exceeds the nanometer range, which is better for the relatively large Dracorin CE (Example 9). In this case, a larger particle size is formed. In addition, in the case of Amphisol K (Example 8), the particle size and stability were similar to those of Eumulgin SG (Example 1 to Example 6).
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