KR101645440B1

KR101645440B1 - Manufacturing method of hydrogel mask comprising plenty of oleaginous components for skin care and hydrogel composition the same

Info

Publication number: KR101645440B1
Application number: KR1020140092982A
Authority: KR
Inventors: 김승국; 윤명석; 원보령
Original assignee: 코스맥스 주식회사
Priority date: 2014-07-23
Filing date: 2014-07-23
Publication date: 2016-08-05
Also published as: CN105473200A; WO2016013772A1; KR20160012261A

Abstract

The present invention relates to a hydrogel composition using a phase inversion temperature (PIT) emulsification method and a preparation method thereof, and more particularly, to a water-soluble gelatinized polymer, purified water, polyhydric alcohol and other additives, / Stirring, and the oily portion containing the nonionic surfactant and oily skin-softening agent is heated to 60 to 95 캜 in a separate container, and then the oily portion and the water-receiving portion are mixed and cooled to a temperature range of 60 to 80 캜 To a method for stably impregnating a PIT emulsion into a gelation product, cooling the product through a cooler, and forming a hydrogel.
According to the present invention, it is possible to facilitate the inclusion of the oil through the PIT emulsification method in the hydrogel which is difficult to contain the oil, so that penetration of the active ingredient in the nano emulsion state becomes effective and the effect can be further improved.

Description

Technical Field [0001] The present invention relates to a method for producing a hydrogel mask, which comprises a large amount of oil and has an excellent skin improving effect, and a hydrogel composition prepared by the method.

The present invention relates to a method for producing a hydrogel and a hydrogel composition prepared thereby. More specifically, the present invention relates to a method for producing a hydrogel composition through a phase inversion temperature (PIT) emulsification process and a hydrogel composition .

In addition to the basic aging factors, modern people are suffering from severe external skin damage due to contaminated external environment, stress in daily life, and increasing frequency of use of makeup products. In order to overcome this, various skin care products such as lotion, cream, and essence are used and dermatological treatment is utilized. However, the use of general skin care products is limited in skin penetration due to the nature of skin tissue, and it is difficult to expect immediate skin improvement. This leads to relatively dangerous procedures such as expensive dermatological treatment and drug treatment. Therefore, it is necessary to have a basic cosmetic product which is effective in skin infiltration but relatively safe and inexpensive.

In recent years, development and consumption of mask sheets using various types of sheets have been actively developed. This is because it is advantageous to use the sheet paper to effectively increase the skin absorption of the contents, but at a relatively low cost. Not only general sheet types but also hydrogels, bio-cellulose and the like have been expanded. The applications of hydrogels are various. Not only cosmetics, but also various applications in the field of skin care and medical care. Most hydrogels use a function to control the release of the drug contained in the supporting hydrogel into the skin while maintaining the gel state. A variety of gelated polymers having a function of forming and retaining a gel are mainly used as a core component of a conventional hydrogel. Many of the hydrogel mask sheet compositions that have been developed in the past are mostly composed of water-soluble components, and even when an oil-soluble component is blended, the use of the suspension agent for differentiating appearance is improved and the feeling of use is slightly improved. In addition, when a large amount of useful ingredient is blended, the oil-soluble component is separated, the viscoelastic property is deteriorated, and the skin is adhered to various problems.

In order to facilitate skin penetration with basic cosmetics, it is advantageous to reduce the particle size of the cosmetic. The form of the cosmetic can be largely divided into solubilization and emulsification. However, there are some problems when it is applied to a hydrogel formulation. In the case of the solubilized type, most of the composition is composed of water-soluble components, which makes it difficult to penetrate the outermost layer of the skin structure composed of the skin and it is not easy to provide the oil required for the skin. In the case of the emulsification type, it is possible to contain a large amount of oil, so that sufficient nutrition can be given to the skin. However, since the particle size is relatively large, absorption of the skin and stable loading in the hydrogel may not be easy, There are technical problems such as problems of gel formation and instability of formulation. In order to overcome these formulation limitations, cosmetics using various methods and materials such as liposomes have been developed, but still remain a difficult task in terms of overcoming the cost limit and applying safe skin.

The PIT emulsifying system is referred to as phase-inversion emulsifying system. When the temperature rises, the degree of hydration of the nonionic surfactant hydrophilic decreases and the hydrophilic lipophilic balance (HLB) changes. In general, surfactants balance hydrophilicity and lipophilicity in aqueous solutions at specific temperatures, which is called the phase inversion temperature of the surfactant. At the phase temperature, the curvature of the hydrophilic part changes from positive to negative, and the number of surfactant associates becomes infinite. In this case, the surfactant phase coexists with the oil phase and the water phase, and is present as a transparent gel state in the bi-continuous phase. At this time, emulsions of small nanoparticles can be obtained by emulsification. This method is a new technology that can produce a fine nano emulsion easily with only the composition of the surfactant without passing through the reaction chamber under high pressure under high pressure, which consumes a lot of energy. When emulsifying a general oil, most emulsions of particles as large as 0.5 to 100 μm are reached. On the other hand, when the PIT emulsification system is used, nano-sized microemulsions can be obtained without difficulty, so that more excellent contents can be produced. In the PIT emulsion, the activity of the hydrophobic group, which is an alkyl chain, becomes stronger in the range of 80 to 95 ° C, and a W / O emulsion phase is formed, and the bacterium phase appears in the range of 61 to 69 ° C by cooling slowly. Can be obtained. In general molding equipment, there is a limit to uniformly quenching high temperature contents at all times, and the cost is also high. However, it was confirmed that the hydrogel mask can be performed by utilizing the condition of quenching through the cooler during the molding process of the hydrogel mask.

Korean Patent No. 10-1240254 discloses a hydrogel sheet mast and a method for producing the hydrogel sheet mast. A hydrogel sheet mast is prepared by incorporating a small amount of an encapsulated active ingredient separately prepared by phase transfer emulsification in a hydrogel production process, Is immersed in a small amount on the outside of the hydrogel to improve the moisture resistance and skin flexibility. However, the present invention maximizes the skin effect and technical value by gelatinizing the entire hydrogel composition using the PIT emulsification method. Generally, the hydrogel process involves a warming process at 90 ° C or higher. Therefore, when a component encapsulated by the phase transfer emulsification method is simply added during the manufacturing process as in the above-mentioned patent (10-1240254), the stability of the capsule Can be broken or deformed and it may be difficult to expect actual effects. The phase transfer emulsification method is a generic term for all emulsification methods in which the type of water (O / W) is changed in the form of water in water (W / O) or in the form of water in water (W / O) .

The technique used in the present invention is to produce a PIT emulsion by the PIT emulsification method. Especially, the PIT emulsion is sensitive to the external temperature because it is made by the emulsification method using a specific temperature range. Therefore, stable emulsion can be formed through proper temperature condition and stable prescription design.

The inventors of the present invention have made intensive studies to overcome the problems of the prior art. As a result, the inventors of the present invention have found that a method for producing a hydrogel by a phase inversion temperature (PIT) emulsification process is a process for producing a hydrogel, It was found that the active ingredient in the nano emulsion state can be easily penetrated into the skin, and the effect can be further improved, thereby completing the present invention.

KR 10-1240254 B

Accordingly, it is a main object of the present invention to provide a PIT (phase inversion temperature) emulsification process which facilitates the inclusion of oil through the PIT method in a hydrogel which is difficult to contain oil, thereby further facilitating penetration of the active ingredient in the nano emulsion state into the skin And a method for producing the hydrogel.

It is another object of the present invention to provide a hydrogel composition prepared using the process for producing a hydrogel by the PIT (phase inversion temperature) emulsification process.

There is provided a method for preparing a hydrogel composition through a phase inversion temperature (PIT) emulsification process including the following steps.

a) heating / stirring the water phase containing water-soluble gelling polymer, purified water, polyhydric alcohol and other additives to a temperature of 60 to 100 캜 in a separate container;

b) heating / stirring the oily phase comprising a non-ionic surfactant and oily skin-softening agent in a separate container to produce a PIT emulsion;

c) adding a PIT emulsion of b) to the gelled product of a), cooling the product to 60 to 80 ° C, and impregnating the gelatinized product with the PIT emulsion; And

d) cooling the hydrogel through a cooler and then molding.

The term " impregnation " of the present invention refers to the inclusion of a PIT emulsion between the network structures of the gelatine.

The term " upper portion " of the present invention is generally referred to as a " water portion " The term " oily part " of the present invention is generally referred to as a " oily part " However, in the present invention, the water phase portion of the water phase contains 50 to 60% by weight of purified water contained in the water phase, which is more than 5 to 10% by weight, which is the amount of purified water contained in the oily phase portion of the present invention, . The water phase part of the present invention is a name of a production part in which purified water, a water soluble gelling polymer and a polyhydric alcohol are mixed, and the oil phase part is a name of a manufacturing part for producing an O / W emulsion by PIT emulsification.

In the present invention, the PIT nanoemulsion used to impregnate the oil inside the hydrogel having the gel network structure is a great discovery. When the general emulsion was impregnated into the hydrogel, the strength of the gel became weak, and the loading of the inside of the gel was impossible. However, it was confirmed that the PIT nanoemulsions could be impregnated in the hydrogel, and that they succeeded in achieving superior efficacy, and completed the present invention. The reason why the hydrogel can be impregnated into the inside of the hydrogel is that the portion emphasized in the present invention is not made possible by simple mixing after forming the hydrogel, but the temperature at which the water-soluble gelling polymer and the water- ) And a temperature at which a PIT emulsion is formed in an oil phase (60 to 95 ° C), respectively, to prepare a gelatin and a PIT emulsion. Then, when the PIT emulsion is prepared by mixing the gelatin and the PIT emulsion, The PIT emulsion is stably impregnated into the gelation while being cooled to the temperature range of 60 to 80 DEG C, so that the PIT emulsion is stably present in the network structure of the gelation, so that the PIT emulsion does not lose its original state, (This state is referred to as " PIT emulsification of the entire hydrogel composition " in the present invention). And it expressed). Such a hydrogel manufacturing process, which was first found in the present invention, realizes a characteristic part of the hydrogel from the actual hydrogel to the industrialization.

More specifically, the dissolution temperature of the water-soluble gelling polymer to make a hydrogel is completely dissolved when it is heated to 60 to 100 ° C, and when it is slowly cooled, the gel starts to be formed at 60 ° C or less. In this way, the PIT emulsion is converted to W / O emulsion at a temperature of 95 ° C or higher and can be easily impregnated into the high-road gel since the bicontinuous layer is formed in the range of 85 to 60 ° C in the course of the slow cooling And it was found. In this process, the nano emulsion could be impregnated into the hydrogel only, and in the case of not simply mixing the emulsion with the ordinary emulsion, it was impossible to impregnate the oil into the hydrogel.

In the present invention, the polyhydric alcohol in the step (a) may be any conventionally used upholol, preferably glycerin, butylene glycol, dipropylene glycol, propylene glycol, hexanediol, 1 , 2-hexanediol, 1,2-pentanediol, propanediol, and 1,2-octanediol.

In the present invention, in the step a), the other additives may include any other additives conventionally added to make the hydrogel, and preferable examples thereof include methyl paraffin, propyl paraben, phenoxyethanol glyceryl caprylate, ethylhexyl glycerin, Caprylic / capric glyceride, and skin-conditioning agents consisting of natural extracts.

In the present invention, in the step b), the nonionic surfactant may be any nonionic surfactant conventionally used, preferably glyceryl monostearate, Ceteth 10-30, Cetearyl 10-30, And Ares 10 to 30.

Generally, a PIT emulsion can be prepared using a nonionic surfactant. According to an embodiment of the present invention, even when a nonionic surfactant is used, a hydrogel produced by a general emulsification method has a problem in that the gel is not formed properly and is broken Respectively. As a result, in the case of a hydrogel prepared by the PIT emulsification method containing a nonionic surfactant, a stable hydrogel in which the size of the emulsion particle is large and the whitening phenomenon is not high or the phenomenon of breakage does not occur can be produced (Comparative Examples 1-2 and 7-9).

In the present invention, the oily skin-softening agent may be at least one selected from the group consisting of a hydrocarbon-based oil, a silicone-based oil, an ester-based oil and a natural oil. Hydrocarbon oils include Mineral oil, Isododecane, and Squalane. Silicone oils can be selected from Dimethicone, Cyclopentasiloxane, and Trisiloxane. The ester system is Octyldodecyl Myristate, Diisostearyl Malate and Isopropyl Myristate. Natural oils are Macadamia nut oil, Sunflower oil. Olive oil may be selected but not limited thereto.

In the present invention, the PIT emulsion in the step c) has an average particle size of 100 to 500 nm.

In the present invention, the water-soluble polymer may be at least one selected from the group consisting of cellulose, konjac, locust bean gum, carob bean gum, alginate, chitosan, starch, pectin, egg yolk, guar gum, mannan, Collagen, gellan gum, xanthan gum, carrageenan, sclerotium gum, and agar.

According to the embodiment of the present invention, when the hydrogel was prepared by changing the kind and content of the water-soluble gelling polymer and oil, it was confirmed that the hydrogel of the emulsion type was well formed although there was a slight difference in the degree of suspension. From these results, it can be seen that stable hydrogels can be prepared through the PIT emulsification process using the water-soluble gelling polymers and oils (skin-softening agents) of the present invention (Examples 2-3 and 3-6).

According to another aspect of the present invention, the present invention provides a hydrogel composition prepared according to the above production method.

According to the experimental example of the present invention, the hydrogel composition prepared by applying the PIT emulsification method has a particle size of 쨉 m as compared with the particles of the hydrogel composition prepared by the general emulsification method On the other hand, it was confirmed that the particles prepared by the PIT emulsification method have a size in the unit of nm. These results indicate that when the PIT emulsification method is applied to the hydrogel composition, the nano-sized composition can more effectively absorb the horny layer of the skin and maximize the effect (see Examples 1 and 10) ).

According to the experimental example of the present invention, it was confirmed that the hydrogel composition of the present invention was superior to the control group in terms of sensation of use, stimulation test, moisturizing power and moisture improvement test. As a result, the hydrogel composition prepared by the PIT emulsification method can provide a more excellent effect than the hydrogel composition prepared by the conventional emulsification method. Such a composition can be used as a mask sheet It is possible to maximize the effect (see Experimental Examples 2-3 and 11-13).

In the present invention, the composition preferably contains 0.1 to 10% by weight of a gelling polymer, 0.1 to 30% by weight of a polyhydric alcohol, 0.1 to 20% by weight of a nonionic surfactant and 0.1 to 30% by weight of a skin- .

When the content of the skin softening agent (oil) is out of the above range, the effect is not felt when the content is less than 0.1% by weight, and when the content is more than 30% by weight, the gel is broken and molding of the hydrogel having a commercial value is impossible. In the case of the water-soluble gelling polymer, if it is out of the above range, if it is less than 0.1% by weight, it is difficult to form into a gel state, and if it exceeds 10% by weight, viscosity is too high. In the case of the polyhydric alcohol, the elasticity of the gel is lowered when the content is less than 0.1% by weight, whereas the effect is not effective when the content is 30% by weight or more. When the amount of the nonionic surfactant is less than 0.1% by weight or more than 20% by weight, problems may arise in forming suitable emulsion particles and stabilizing the formulation.

In the present invention, the composition is characterized by being in the form of a mask sheet.

The hydrogel composition using the PIT emulsification method according to the present invention can simultaneously satisfy nutrition and moisture of the skin by simultaneously providing moisture and oil, and can be manufactured in a small particle size simply without special manufacturing equipment, High hydrogels can be made.

1 and 2 are views showing the form of a hydrogel prepared according to the method of Example 1 of the present invention.
3 and 4 are views showing the shape of a hydrogel prepared according to the method of Example 2 of the present invention.
5 and 6 are views showing the shape of the hydrogel prepared according to the method of Example 3 of the present invention.
FIGS. 7 and 8 are views showing the shape of the hydrogel prepared according to the manufacturing method of Comparative Example 1 of the present invention. FIG.
9 is a view showing the shape of the hydrogel prepared according to the manufacturing method of Comparative Example 2 of the present invention.
10 is a graph showing the results of comparison of the particle sizes of the general emulsification method and the PIT emulsification method of Experimental Example 1 of the present invention.
FIG. 11 is a view showing the shape of a hydrogel prepared according to the production method of Experimental Example 3 of the present invention (from the left, control, macadamia oil, dimethicone (6cs), octyldodecyl myristate).
FIGS. 12 and 13 are diagrams showing the results of moisture and water improving test results of the hydrogel prepared according to the production method of Experimental Example 3. FIG.
Fig. 14 is a view showing the shape of the hydrogel produced according to the production method of Example 3, and showing the result of Experimental Example 4. Fig.
FIG. 15 is a view showing the shape of the hydrogel prepared according to the manufacturing method of Example 2, and showing the result of Experimental Example 4 (from the left, control, macadamia oil, dimethicone, octyldodecyl myristate).

Hereinafter, the present invention will be described in more detail with reference to Examples. These embodiments are only for illustrating the present invention, and thus the scope of the present invention is not construed as being limited by these embodiments.

Example One: PIT Through the emulsification process Hydrogel Produce

The composition shown in Table 1 below was prepared as follows.

Mineral oil, nonionic surfactant Ceteth-20, Steareth-20 and glyceryl stearate, cetearyl alcohol and preservative were added to the oily dissolving tank and dissolved by heating at 70 ~ 85 ℃. Lt; RTI ID = 0.0 > PIT < / RTI > Add the water-soluble gelling polymer, polyhydric alcohol and other additive portion heated / dissolved in a separate water dissolving tank, and stir the mixture sufficiently. When the contents are finished, the contents are discharged, and the contents are cooled using a cooler to gel. In the present invention, it is a key point to design the preparation method so as to be in conformity with the PIT production temperature and the dissolution temperature of the hydrogel. More specifically, the temperature at which the composition of the water-soluble part shown in Table 1 is dissolved is in the range of 70 to 105 ° C. In order to encapsulate the nanoemulsions in the hydrogel, the preparation temperature of the PIT nanoemulsions must be the same, It was confirmed that when the PIT composition shown was selected, the PIT formation temperature selectively appeared in the range of 70 to 85 ° C. Based on this theory, it can be seen that a very fine nanoemulsion is packed inside the hydrogel when the hydrogel is produced. In doing so, the hydrogel was able to develop a hydrogel of high quality, which was free from staining and was elastic, moist and high quality.

Water top content Water 62.6 Xanthan Gum 0.3 CARRAGEENAN 0.4 Gellan Gum 0.6 Glycerin 15 The oil phase (PIT production section) Mineral oil (mineral oil) 7.0 Ceteth-20 One Steareth-20 One Glyceryl Stearate One Cetearyl Alcohol 0.5 Phenoxyethanol 0.5 Water 10 CaCl ₂ &Lt; 0.1

As a result, as shown in Fig. 1 and Fig. 2, it can be seen that a thin and elastic formulation with a milky white color is completed.

Example 2: water soluble Gelling Depending on the type and content of polymer PIT Through the emulsification process Hydrogel Produce

Was prepared in the same manner as in Example 1 with the composition shown in Table 2 below.

Water top content Water 62.2 Xanthan Gum 0.3 CARRAGEENAN 0.4 Ceratonia Siliqua Gum 0.8 Agar 0.3 Glycerin 15 The oil phase (PIT production section) Mineral oil (mineral oil) 7.0 Ceteth-20 One Steareth-20 One Glyceryl Stearate One Cetearyl Alcohol 0.5 Phenoxyethanol 0.5 Water 10

As a result, as shown in Figs. 3 and 4, it can be seen that a thin and resilient formulation with a milky white color is completed.

Example 3: water soluble Gelling Depending on the kind of polymer, kind of oil and content of oil part PIT Through the emulsification process Hydrogel Produce

Was prepared in the same manner as in Example 1 with the composition shown in Table 3 below.

Water top content Water 47 Xanthan Gum 0.4 CARRAGEENAN 0.8 Ceratonia Siliqua Gum 0.6 Gellan Gum 0.6 Glycerin 20 The oil phase (PIT production section) Dimethicone (6cs) (silicone oil) 10 Ceteth-20 2 Steareth-20 2 Glyceryl Stearate 2 Cetearyl Alcohol One Phenoxyethanol 0.5 Water 13 CaCl ₂ &Lt; 0.1

As a result, as shown in FIGS. 5 and 6, as the type of oil and the amount of the oil phase increase, the suspension degree is different but it can be confirmed that the emulsion-type hydrogel is well formed.

Comparative Example 1: Oil and Nonion Surfactant-free PIT Preparation of Hydrogel by Emulsification Process

(Oil, nonionic surfactant, Cetearyl Alcohol) in the composition of Example 1 was prepared in the same manner as in Example 1.

As a result, it can be confirmed that a hydrogel in a transparent form is produced as shown in FIGS.

Comparative Example 2: Through general emulsification method Hydrogel Produce

The same procedure as in Example 1 was carried out except that the emulsion was not a PIT emulsion but a general emulsion. As shown in the composition of Table 4, the water-soluble gelling polymer and the polyhydric alcohol are dissolved in the upper portion of the water, and the nonionic surfactant and oily skin-softening agent are heated / dissolved in the separate oily portion. When the contents are finished, the contents are discharged, and the contents are cooled using a cooler to gel.

Water top content Water To 100 Xanthan Gum 0.3 CARRAGEENAN 0.4 Gellan Gum 0.6 Glycerin 15 Floating Mineral oil (mineral oil) 7.0 Ceteth-20 One Steareth-20 One Glyceryl Stearate One Cetearyl Alcohol 0.5 Phenoxyethanol 0.5 CaCl ₂ and other additives &Lt; 0.1

As a result, as shown in FIG. 9, it is confirmed that the emulsion particle size is greatly formed, the whiteness is high, and the gel formation is not performed properly, resulting in breakage.

Experimental Example One: General emulsification method PIT Emulsifying Size of particle size compare

In the present invention, the influence of oil particles on the impregnation of oil into the hydrogel having a gel network structure was examined. This experiment suggests some of the results of the experiment to further propose the technical part of the present invention more positively. However, this result does not constitute the entirety of the present invention, and it is intended to disclose some comparative results.

The emulsifier using the PIT emulsification method was prepared in Example 1 and the particle size was measured. On the other hand, as the emulsifier used in the emulsion system using the general emulsification method, Polysorbate-60 and glyceryl monostearate were mixed and used as the surfactant most commonly used (Table 5 below) The procedure of Example 1 was repeated. Also, the concentration used was the same as the total concentration of the surfactant using the PIT emulsification method.

Water top content Water 62.6 Xanthan Gum 0.3 CARRAGEENAN 0.4 Gellan Gum 0.6 Glycerin 15 The oil phase (PIT production section) Mineral oil (mineral oil) 7.0 Glyceryl Stearate 1.2 Polysorbate-60 2.3 Phenoxyethanol 0.5 Water 10 CaCl ₂ &Lt; 0.1

As a result, as shown in Fig. 10, in the emulsion system using the PIT emulsification method, when the mineral oil concentration was 3%, the average particle diameter was 87 nm, and the average particle diameter at 5% was 98 nm and 7% Was 105 nm, and was distributed around 100 nm.

On the other hand, in the case of the emulsion system using the general emulsification method, when the mineral oil concentration was 3%, the average particle diameter was 5.2 탆, the average particle diameter at 5% was 9.6 탆 and the average particle diameter at 10% It was found that very large particles were formed in the range of 5 ~ 10μm.

It was additionally found that this result was due to a great influence on the stability of the oil packed in the hydrogel. The oil using the general emulsification method was very poor in stability when impregnated in the hydrogel, and the strength of the gel was also weak and the oil was easily broken. However, it was found that the PIT nanoemulsions were stably loaded in the hydrogel, and the stability and the strength of the gel were maintained.

As a result, it was expected that there would be excellent differentiation from the viewpoint of skin efficacy of the hydrogel.

Hereinafter, the present invention will be described with reference to the following examples. However, these embodiments are merely examples of the present invention and are not intended to limit the scope of the present invention.

Experimental Example 2: Feeling And skin irritation test

Using the above Example 1 and Comparative Example 1, 30 men and 15 women were attached to the face for 20 minutes, and a feeling of use and a stimulation test were carried out. As a result, as shown in the following Table 6, it can be seen that Example 1 improved in overall evaluation items such as skin moisturization, flexibility, and stimulation as compared with Comparative Example 1. A much higher improvement in skin moisturizing and suppleness was noticed, which is expected to increase the moisturizing and suppleness of the skin, with a content level of oil similar to that of emulsions in general.

Evaluation items Female (n = 15) Man (n = 15) Example 1 Comparative Example 1 Example 1 Comparative Example 1 Skin moisturizing power 4.2 3.3 4.4 3.6 Skin flexibility 4.4 3.5 4.5 3.2 Skin irritation 4.3 4.0 4.4 4.2 Overall satisfaction 4.6 3.0 4.5 3.4

Evaluation criteria: Excellent (5 points) / Excellent (4 points) / Average (3 points) / Poor (2 points) / Very poor (1 point)

Experimental Example 3: Moisture power And moisture improvement test

Based on the results of Experimental Example 2, moisture and moisture improvement tests were conducted to obtain more objective data. The experiment was carried out after changing only the kind of oil in the same prescription as shown in Table 7 and manufacturing the same through the same manufacturing method as in Example 1. The oil used was the same amount of representative vegetable oil (Macadamia oil), silicone oil (Dimethicone 6cs) and ester oil (Octyldodecyl Myristate).

Water top Control Macadamia oil Dimethicone (6cs) Octyldodecyl Myristate Water To 100 Xanthan Gum 0.3 CARRAGEENAN 0.4 Ceratonia Siliqua Gum 0.8 Agar 0.3 Glycerin 15 Floating Oil - 7.0 7.0 7.0 Ceteth-20 One Steareth-20 One Glyceryl Stearate One Cetearyl Alcohol 0.5 Phenoxyethanol 0.5

- Measuring method: After the product is put on the test area for 30 minutes and absorbed, the moisture is measured immediately before use (30 minutes), 2 hours, 4 hours and 8 hours.

- Results analysis: Moisture is calculated using the mean value measured three times.

- Subjects: 18 healthy adults and 12 males (mean age 25)

- Test site: Arms (medial side, 2 x 2 cm ² )

- Measuring instrument: Moisture measurement - Corneometer CM 825

- Test substance: 1. Control hydrogel

2. Macadamia nut oil

3. Dimethicone (6CS)

4. Eutanol GM

As a result, all four species such as Control Hydrogel showed high skin moisturizing effect up to 8 hours, and Macadamia nut oil and Eutanol GM showed higher moisturizing effect than Control Hydrogel (FIG. 11 to FIG. 13).

Claims

A method of preparing a hydrogel composition having a formulation in the form of a mask sheet comprising the steps of:
a) In a separate container, the following ingredients may be added to the container: cellulose, konjac, locust bean gum, chicago gum, alginate, chitosan, starch, pectin, egg yolk, guar gum, mannan, pluronian gum, pluran, collagen, , At least one water-soluble gelling polymer selected from the group consisting of carrageenan, sclerotium gum and agar, purified water, polyhydric alcohol and other additives, at 60 to 100 캜;
b) in a separate container, at least one nonionic surfactant selected from the group consisting of glyceryl monostearate, ceteth 10-30, cetearate 10-30 and steares 10-30, and oily skin softening agent / RTI > to 60 to < RTI ID = 0.0 > 95 C < / RTI > to produce a PIT emulsion;
c) introducing the PIT emulsion of b) into the gelatine of a) and firstly cooling to 60 to 80 ° C to impregnate the PIT emulsion into the gelation; And
d) secondarily cooling the hydrogel through a cooler, and then molding it into a formulation in the form of a mask sheet.

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A composition comprising 0.1 to 10% by weight of a gelled polymer based on the total weight of the composition, 0.1 to 30% by weight of a polyhydric alcohol, 0.1 to 20% by weight of a nonionic surfactant and 0.1 to 30% by weight of a skin- &Lt; / RTI > wherein the composition is in the form of a mask sheet.

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