WO2016006889A1 - Implant dentaire à revêtement de surface présentant une bioaffinité et une biocompatibilité améliorées et procédé de fabrication associé - Google Patents

Implant dentaire à revêtement de surface présentant une bioaffinité et une biocompatibilité améliorées et procédé de fabrication associé Download PDF

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WO2016006889A1
WO2016006889A1 PCT/KR2015/006928 KR2015006928W WO2016006889A1 WO 2016006889 A1 WO2016006889 A1 WO 2016006889A1 KR 2015006928 W KR2015006928 W KR 2015006928W WO 2016006889 A1 WO2016006889 A1 WO 2016006889A1
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Prior art keywords
formula
implant
dental implant
coated
coating
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PCT/KR2015/006928
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English (en)
Korean (ko)
Inventor
장일석
김효원
김수경
송주동
엄태관
최규옥
이해신
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오스템임플란트 주식회사
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Priority claimed from KR20140087630A external-priority patent/KR101460974B1/ko
Priority claimed from KR20140087629A external-priority patent/KR101460976B1/ko
Priority claimed from KR20140087631A external-priority patent/KR101460973B1/ko
Application filed by 오스템임플란트 주식회사 filed Critical 오스템임플란트 주식회사
Publication of WO2016006889A1 publication Critical patent/WO2016006889A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/30—Inorganic materials
    • A61L27/32—Phosphorus-containing materials, e.g. apatite

Definitions

  • the present invention relates to a dental implant and a method for manufacturing the same by improving the biocompatibility of the implant by coating the surface of the implant using the composition for implant coating, such as hydrophilicity, blood affinity, bone formation promoting ability and bone interface binding strength of the implant, More particularly, the present invention relates to a dental implant and a method for producing the same, which are coated with a pre-treated implant surface using an implant coating composition, thereby improving biocompatibility or biocompatibility.
  • the composition for implant coating such as hydrophilicity, blood affinity, bone formation promoting ability and bone interface binding strength of the implant
  • Dental implants are used to permanently implant artificial teeth on the jaw bone of humans.
  • the dental implant connects the jaw bone with artificial teeth and handles and distributes the load generated when chewing food. It is mechanically manufactured to serve as a more stable tooth than a conventional denture. Therefore, the implant should be made of biocompatible materials that are very stable against human tissues and should be free of side effects and other chemical and biochemical reactivity. In addition, it is very difficult to select a suitable material because the mechanical strength must be very high so as not to be deformed and destroyed even under repeated loads and instantaneous pressures.
  • Titanium (Ti) metals and alloys are mainly used (Larry L. Hench, "Bioceramics", J. Am. Ceram. Soc. 81 (7) 1705 -1728, 1998). Titanium or its alloys are not only easy to process but also have the advantages of high biocompatibility, high mechanical strength and bioinertness to human tissues. However, Ti and its alloys have a disadvantage in that the bonding time with the bone is long when transplanted into the human body, and metal ions melt into the living body after a long time after transplantation.
  • Implants with irregular surfaces are effective for rapid bone growth and good mechanical adhesion, and implants with irregular and rough surfaces. Has been reported to have more bone contact rates than implants with smooth surfaces.
  • the first-generation implant is an implant with a smooth surface
  • the second-generation implant is an implant with an anodized surface.
  • TPS Transsorbable Blasted Media blasting
  • RBM Resorbable Blasted Media blasting
  • the product is exposed to air after the surface treatment process.
  • the oxide layer grows on the surface of the product, and adsorption of various pollutants such as hydrocarbons occurs, resulting in hydrophobization while changing to a chemically stable state. That is, the hydrophobized surface has a disadvantage of prolonging the period of stabilization of the implant by preventing the overall process of fusion with the bone after implant implantation because of low wettability to body fluids and blood.
  • US Patent 6670855 discloses a method of chemically etching with inorganic acids such as hydrochloric acid, sulfuric acid, nitric acid, etc. as a method of improving the hydrophilicity of the roughened surface of the titanium implant, Plasma treatment (Radio-Frequency Glow Discharge (RFGD), O2, etc.), light irradiation (ultraviolet radiation, ultraviolet-ozone) as a method of imparting hydrophilicity of the metal surface to overcome the disadvantages of hydrophobicity of titanium surface Etc.).
  • inorganic acids such as hydrochloric acid, sulfuric acid, nitric acid, etc.
  • Plasma treatment Radio-Frequency Glow Discharge (RFGD), O2, etc.
  • light irradiation ultraviolet radiation, ultraviolet-ozone
  • the present invention provides a composition for implant surface coating that can be coated on the surface of the implant, thereby improving the hydrophilicity, blood affinity, bone formation promoting ability, etc. of the implant surface, by using the same, improved biocompatibility and biocompatibility
  • the present invention proposes a method for preparing a dental implant and a dental implant manufactured by the method.
  • an object of the present invention is a method of coating an implant surface using a composition for implant surface coating comprising a compound selected from the group consisting of compounds represented by the following [Formula 1] to [Formula 3] or a salt thereof as an active ingredient And the implant surface coating composition is coated to provide a dental implant with improved biocompatibility and biocompatibility.
  • R1 is -PO (OH) 2 or -SO 2 (OH)
  • R2 is hydrogen or -OH
  • R3 is hydrogen or -NH 2
  • R4 is oxygen or -NH 2 .
  • a 1 and a 2 are each independently —PO (OH) 2 or —SO 2 (OH), and Q 1 and Q 2 are each independently hydrogen or —NH 2 .
  • a is -PO (OH) 2 or -SO 2 (OH).
  • Another object of the present invention is to provide a method for treating a surface of an implant comprising: (a) pretreatment to roughen the surface of the implant; And (b) roughening the implant coating composition comprising a compound selected from the group consisting of compounds represented by the above [Formula 1] to [Formula 3] or salts thereof as an active ingredient in the pretreatment step (a).
  • a dental implant manufacturing method with improved biocompatibility or biocompatibility, such as hydrophilicity, blood affinity, bone formation promoting ability and bone interface binding strength of the implant.
  • the dental implant with improved biocompatibility presented in the present invention comprises a compound selected from the group consisting of compounds represented by the following [Formula 1] to [Formula 3] or salts thereof as an active ingredient, on the surface of the dental implant
  • the concentration of the composition to be coated is 0.05 to 0.5 M, pH is characterized in that 5 to 9.
  • R1 is -PO (OH) 2 or -SO 2 (OH)
  • R2 is hydrogen or -OH
  • R3 is hydrogen or -NH 2
  • R4 is oxygen or -NH 2 .
  • a 1 and a 2 are each independently —PO (OH) 2 or —SO 2 (OH), and Q 1 and Q 2 are each independently hydrogen or —NH 2 .
  • a is -PO (OH) 2 or -SO 2 (OH).
  • the compound selected from the group consisting of the compound represented by the above [Formula 1] to [Formula 3] or a salt thereof is coated on the surface of the implant is preferably coated on the dental implant surface in an amount of 10 ⁇ 40 ⁇ g / mm. .
  • the compound of [Formula 1] is preferably 2'-deoxyadenosine 5'-monophosphate (hereinafter referred to as 'DAP') or 2'-deoxycytidine 5'-monophosphate (hereinafter referred to as 'DCP').
  • the compound of [Formula 2] is preferably 4,4'-Diaminostibene-2,2'-disulfonic acid (hereinafter referred to as 'DASDA').
  • the compound represented by [Formula 3] or a salt thereof it is preferable to coat the surface of the dental implant in an amount of 1 ⁇ g / mm 2 ⁇ 1 mg / mm 2, wherein the compound of Formula 3 is N-Tris (hydroxymethyl) It is preferably methyl-3-aminopropanesulfonic acid (hereinafter referred to as 'TAPS').
  • the dental implant coating composition used in the present invention includes DAP, DCP, DASDA, TAPS or salts thereof as an active ingredient, pH is 5 ⁇ 9, more preferably 0.05 ⁇ 0.5 in the range of pH 6 ⁇ 8 It is included in the concentration of M.
  • the composition containing DAP, DCP, DASDA or salts thereof is coated in an amount of 10-40 ⁇ g / mm 2 per unit area, and the composition containing TAPS or salt thereof is 1 ⁇ g per unit area. / Mm2-1 mg / mm2.
  • Another embodiment of the present invention is a method for manufacturing a dental implant, (a) pre-treatment step of roughening the surface of the dental implant through the blasting and acid treatment step; And (b) a composition comprising a compound selected from the group consisting of the compounds represented by the above [Formula 1] to [Formula 3] or a salt thereof as an active ingredient, the coating on the implant surface subjected to the pretreatment step (a) It includes; step.
  • Dental implants coated with the composition for implant coating presented in the present invention has the advantage that the surface hydrophilicity, blood affinity and bone-interface force is improved, the bone formation of the peripheral portion implanted is greatly increased, dental implants The biocompatibility or biocompatibility of the is greatly improved.
  • Figure 1 shows the results of the contact angle test of the coated dental implant.
  • Figure 2 shows the results of blood affinity measurement experiment of the coated dental implant of the present invention.
  • Figure 3 shows the experimental results of measuring the bone interface binding force of the coated dental implant of the present invention.
  • Figure 4 is a ⁇ -CT imaging results for bone interface morphometric evaluation of the coated dental implant of the present invention.
  • the compounds represented by [Formula 1] to [Formula 3] of the present invention may be used in the form of a salt thereof, or a pharmaceutically acceptable salt thereof.
  • 'pharmaceutically acceptable refers to a physiologically acceptable and normally does not cause an allergic or similar reaction when administered to a human, and as the salt, a pharmaceutically acceptable free acid Acid addition salts formed by
  • R1 is -PO (OH) 2 or -SO 2 (OH)
  • R2 is hydrogen or -OH
  • R3 is hydrogen or -NH 2
  • R4 is oxygen or -NH 2 .
  • a 1 and a 2 are each independently —PO (OH) 2 or —SO 2 (OH), and Q 1 and Q 2 are each independently hydrogen or —NH 2 .
  • a is -PO (OH) 2 or -SO 2 (OH).
  • an organic acid or an inorganic acid may be used, and as the organic acid, citric acid, acetic acid, lactic acid, tartaric acid, maleic acid, fumaric acid, formic acid, propionic acid, oxalic acid, trifluoroacetic acid, benzoic acid, gluconic acid, meta Sulfonic acid, glycolic acid, succinic acid, 4-toluenesulfonic acid, glutamic acid, aspartic acid, and the like, but are not particularly limited thereto.
  • the inorganic acid includes hydrochloric acid, bromic acid, sulfuric acid, phosphoric acid, and the like, but is not limited thereto.
  • composition for implant coating of the present invention may be molded and used in the form of putty, paste, moldable strip, block, chip, etc. using a method of compression, compression, pressure contact, packing, pressing, hardening, and the like, and chemical additives. It may be used in the form of gels, powders, pastes, tablets, pellets, etc., but is preferably used in the form of an aqueous solution.
  • the concentration of the coating composition to be coated on the implant surface is 0.05 ⁇ 0.5 M
  • the pH is preferably 5 ⁇ 9, more preferably 6 ⁇ 8
  • the surface of the implant [Formula 1]
  • the compound represented by [Formula 2] is preferably coated in an amount of 10 to 40 ⁇ g / mm 2
  • the compound represented by [Formula 3] is preferably coated in an amount of 1 ⁇ g to 1 mg / mm 2.
  • the concentration when the concentration is less than 0.05 M, the amount of the coating on the implant surface may be too small to improve the biocompatibility, and when the concentration is 0.5 M or more, it is difficult to uniformly coat the entire surface due to the high viscosity.
  • the thick coating layer causes problems such as long-term dropout stability due to vibration and dropping.
  • the pH is preferably in the range of about 5 to 9, which is a neutral region including weakly acidic to weakly basic regions.
  • the pH is less than 5, the surface of the implant base may be oxidized.
  • the pH is more than 9 is not preferable because the problem of lowering the material stability of the coating composition itself.
  • DAP 2'-deoxyadenosine 5'-monophosphate
  • DASDA 4,4'-Diaminostibene-2,2'-disulfonic acid
  • DASDA 4,4'-Diaminostibene-2,2'-disulfonic acid
  • TAPS N-Tris (hydroxymethyl) methyl-3-aminopropanesulfonic acid
  • the dental implant coating composition used in the present invention includes DAP, DCP, DASDA, TAPS or a salt thereof as an active ingredient, pH is contained in a concentration of 0.05 to 0.5 M in the range of 5-9.
  • the composition comprising DAP, DCP, DASDA or salts thereof is preferably coated in an amount of 10-40 ⁇ g / mm 2 per unit area of the implant.
  • a composition containing TAPS or a salt thereof may be used per 1 implant unit area. It is preferable to coat in an amount of ⁇ g / mm 2 to 1 mg / mm 2.
  • the amount of coating is less than the above range there is a problem that can not cover the entire surface of the implant, if the coating amount exceeding the above range because a thick coating layer is formed, problems such as dropping due to vibration during distribution As it may, it is not preferable.
  • an additional biologically active substance when used for coating the surface of the implant in the form of such an aqueous solution, an additional biologically active substance may be added and used, growth factors for promoting bone growth, peptides and proteins for promoting bone tissue formation, Fibrin, bone morphogenic factors, bone growth agents, chemotherapeutic agents, antibiotics, analgesics, bisphosphonates, strontum salts, fluoride salts, magnesium salts, sodium salts and the like can be used.
  • the growth factors include bone morphogenic protein (BMP), platelet-derived growth factor (PDGF), transgenic growth factor (TGFbeta), insulin-like growth factor (IGF-I), IGF-II, fibroblast growth factor (FGF) and BGDF-II (beta-2-microglobulin), and the like, and the bone tissue formation-promoting peptides and proteins include various peptides including RGD sequences and various proteins such as collagen and fibronogen.
  • BMP bone morphogenic protein
  • PDGF platelet-derived growth factor
  • TGFbeta transgenic growth factor
  • IGF-I insulin-like growth factor
  • IGF-II insulin-like growth factor
  • FGF fibroblast growth factor
  • BGDF-II beta-2-microglobulin
  • Osteocalcin, bonesialo protein, osteogenin, BMP, and the like may be used as bone morphogenesis factors, and the bone growth agent may be harmful if it is harmless to the human body and promotes bone growth. It can be used without, nucleic acids that promote bone formation, antagonists of substances that inhibit bone formation, and the like.
  • step (a) a pretreatment step of roughening the surface of the implant; And (b) coating the implant coating composition of the present invention on the surface of the implant pretreated in step (a).
  • the step (a) is a step of pretreating the surface of the implant before coating with the composition for implant coating of the present invention
  • various pretreatment methods known in the art can be used.
  • RBM Resorbable Blasting Media
  • SA Small Large grit, and Acid etched surface treatment method after etching with aluminum after aluminum blasting
  • UV irradiation temperature above 300 °C Heat treatment
  • anodizing acid treatment, and heat treatment after base treatment, and the like
  • UV irradiation or SA Sand-blasted Large grit and Acid etched
  • the material of the implant used in the present invention is not particularly limited, and all known implant materials are possible, and ceramics such as Glass, ITO, synthetic polymers such as PU, PTFE, and metals may be used as SiO 2 , Pt, St, Titanium, a titanium alloy, etc. are mentioned.
  • ceramics such as Glass, ITO, synthetic polymers such as PU, PTFE, and metals may be used as SiO 2 , Pt, St, Titanium, a titanium alloy, etc. are mentioned.
  • titanium or titanium alloy may be used, and in the aforementioned pretreatment (surface treatment) step, nitric acid solution may be used to remove carbon hydroxide on the surface of the titanium or titanium alloy implant.
  • the nitric acid solution is preferably about 4 v / v% to 60 v / v%, and the nitric acid solution cleaning process may be omitted depending on the hydrophilic property and shape of the surface.
  • nitric acid washing it is preferable to wash the surface with distilled water to remove residual nitric acid from the surface, and the surface washing process of distilled water may be omitted on the surface where the nitric acid solution cleaning process is omitted, but following the alcohol washing step to remove impurities Can be used.
  • Step (b) is a step of coating the surface of the implant using the composition for implant coating of the present invention
  • specific implant surface coating method may include a physical and chemical coating method. Specific examples include pulsed laser deposition (PLD), sputtering, sputtering, chemical vapor deposition (CVD), dip coating, spin coating, plating, and three-dimensional plasma dry deposition ( 3D plasma gun deposition).
  • PLD pulsed laser deposition
  • CVD chemical vapor deposition
  • dip coating spin coating
  • plating plating
  • 3D plasma gun deposition three-dimensional plasma dry deposition
  • the coating composition of the present invention may be dried by a simple application process on the surface of the implant, thereby performing a coating step. At this time, the room temperature drying time may be about 1 to 24 hours, more preferably 1 to 3 hours.
  • the surface-coated implant using the coating composition of the present invention has the advantage of maintaining or enhancing the biocompatibility of the implant even after a long time.
  • Specimens used were made of titanium (CP Ti Gr4, Siwon company, USA) in a precision CNC dedicated to implants (CINCOM.L20VIII, Japan) with a diameter of 10 mm, a thickness of 1 mm and a screw shape of 1.5 mm and a length of 1.5 mm.
  • CP Ti Gr4, Siwon company, USA CP Ti Gr4, Siwon company, USA
  • CNC dedicated to implants CINCOM.L20VIII, Japan
  • macro-morphology was applied to the surface of the implant using an acid treatment method using a mixed acid aqueous solution. And micro-morphology.
  • the implant was washed.
  • the acid-treated dental titanium implant was ultrasonically cleaned for 30 minutes with ethanol and for 30 minutes with distilled water and then dried.
  • the treated implant was treated with plasma for 1 minute or ultraviolet light for 5 minutes to remove contaminants adsorbed and stabilized on the surface, and pH 0.1 M TMP, FA, MDP, DAP, DCP, DASDA and TAPS aqueous solutions were applied to the surface. After adjusting to 7, uniformly uniformly applied, and dried at room temperature to prepare a 25 ⁇ g / mm 2 (0.5 mg / mm 2 in the case of TAPS) coating amount. TMP, FA, MDP, DAP, DCP, DASDA and TAPS aqueous solution prepared by this method was coated in the following [Example 2].
  • the Sessile drop method was used to measure the hydrophilicity of the coated implant surface prepared in [Example 1].
  • the TMP, FA, MDP, DAP, DCP, DASDA and TAPS coated titanium disks prepared in [Example 1] were left for 18 weeks (accelerated aging 3 years) under accelerated aging conditions (55 ° C). After that, 10 ml of distilled water was dropped into each of the accelerated aging disks, respectively, and the contact angle between the surface and distilled water was measured. In order to accurately measure the contact angle, a picture was taken with a video camera-equipped device (Contact angle measurement, Surface Tech, Korea), and the left and right contact values were measured, and then an average value (Contact angle) was obtained.
  • a video camera-equipped device Contact angle measurement, Surface Tech, Korea
  • the SA disk immediately after the manufacture of the surface coating is not made as a positive control, the SA disk accelerated aging in a state in which the surface coating is not made as a negative control.
  • the contact angle of distilled water in TMP, FA, MDP, DAP, DCP, DASDA and TAPS coated experimental groups compared to the negative control group having a contact angle of 121 ° for 18 weeks (accelerated aging) 3 years. It can be seen that the contact angle is lowered to about 0 °, 12 °, 60 °, 0 °, 0 °, 0 °, and 0 °, respectively, thereby improving the hydrophilicity of the coating surface.
  • the dental implant coated with the surface prepared in Example 1 was left for 18 weeks under accelerated aging conditions (55 ° C.), and then the implant was immersed in micropig blood for about 3 mm for 3 minutes to check blood affinity. After that, the blood wettability was confirmed by the height of the blood coming up the surface of the implant.
  • the SA control which was not coated with the materials immediately after the preparation was used as the positive control, and the SA implant that was subjected to accelerated aging conditions without coating the material as the negative control was used.
  • the negative control SA implant had 1.5 mm of blood coming up the surface of the implant for 3 minutes, whereas 6 mm, 4 mm, and 3 mm for TMP, FA, MDP, DAP, DCP, DASDA and TAPS, respectively. , 8.5 mm, 8 mm, 8.3 mm and 8.5 mm was found to significantly improve the blood wettability.
  • TMP, FA, MDP, TMP, FA, MDP, DAP, DAP, DCP, DASDA and TAPS prepared in [Example 1] were confirmed to have excellent blood affinity through [Example 3] dental implants.
  • DAP, DCP, DASDA, and TAPS coated implants were left for 18 weeks (accelerated aging) for 18 weeks under accelerated aging conditions (55 ° C), and the implant and bone-interface binding force were confirmed.
  • the surface-coated implant was placed in the tibia of the rabbit to measure the implant and bone-interfacial binding force, and the torque was measured after 14 days of bone formation.
  • the surface-free SA implant immediately after preparation was used, and as a negative control, an accelerated aging SA implant was used for the same period without the surface being coated.
  • implantation of TMP, DAP, DCP, DASDA and TAPS surface-coated implants into micro pig mandible was performed and then morphometric measurement by ⁇ CT imaging after 16 days of bone formation period. Physiological evaluation was performed.
  • the dental implants coated with DAP, DCP, DASDA and TAPS have a significantly increased degree of bone formation around the implant compared to the negative control. You can see that.
  • Dental implants coated with the composition for implant coating presented in the present invention is improved hydrophilicity, blood affinity and bone-interface force of the surface, increased bone formation in the periphery in which the implant is placed, bio-compatibility of the dental implant Alternatively, since there is an effect of greatly improving biocompatibility, there is industrial applicability.

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • General Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Transplantation (AREA)
  • Medicinal Chemistry (AREA)
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  • Inorganic Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dentistry (AREA)
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Abstract

La présente invention concerne un implant dentaire et un procédé de fabrication associé, l'implant dentaire présentant une meilleure bioaffinité telle que l'hydrophilie, l'hémocompatibilité, la capacité de promotion de l'ostéogenèse et la force de liaison à l'interface osseuse par revêtement de la surface de l'implant dentaire avec une composition de revêtement d'implants. La présente invention concerne, plus spécifiquement, un implant dentaire présentant une meilleure bioaffinité ou biocompatibilité par revêtement de la surface pré-traitée de l'implant à l'aide d'une composition de revêtement d'implants, et un procédé de fabrication associé. L'implant dentaire revêtu d'une composition de revêtement d'implants, conformément à la présente invention, présente les avantages d'une amélioration de l'hydrophilie, de l'hémocompatibilité et de la force de liaison à l'interface osseuse et d'une amélioration de l'ostéogenèse autour d'un implant implanté. Il présente également des effets d'amélioration de la bioaffinité et de la biocompatibilité de l'implant dentaire.
PCT/KR2015/006928 2014-07-11 2015-07-06 Implant dentaire à revêtement de surface présentant une bioaffinité et une biocompatibilité améliorées et procédé de fabrication associé WO2016006889A1 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
KR10-2014-0087629 2014-07-11
KR10-2014-0087630 2014-07-11
KR20140087630A KR101460974B1 (ko) 2014-07-11 2014-07-11 표면이 코팅되어 생체 적합성이 향상된 치과용 임플란트 및 이의 제조 방법
KR10-2014-0087631 2014-07-11
KR20140087629A KR101460976B1 (ko) 2014-07-11 2014-07-11 표면이 코팅되어 생체 친화성이 향상된 치과용 임플란트 및 이의 제조 방법
KR20140087631A KR101460973B1 (ko) 2014-07-11 2014-07-11 표면이 코팅되어 생체 친화성과 생체 적합성이 향상된 치과용 임플란트 및 이의 제조 방법

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009148581A (ja) * 2000-07-26 2009-07-09 Straumann Holding Ag 表面を修飾したインプラント
KR101248785B1 (ko) * 2012-04-30 2013-04-03 오스템임플란트 주식회사 초친수성을 갖는 티타늄 임플란트, 그 표면처리 및 보관 방법
KR20130044918A (ko) * 2011-10-25 2013-05-03 오스템임플란트 주식회사 임플란트 표면의 생체활성을 증진시키는 유기용매를 이용한 임플란트 및 그 제조방법
KR101404632B1 (ko) * 2013-05-02 2014-06-27 오스템임플란트 주식회사 임플란트의 표면처리방법

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009148581A (ja) * 2000-07-26 2009-07-09 Straumann Holding Ag 表面を修飾したインプラント
KR20130044918A (ko) * 2011-10-25 2013-05-03 오스템임플란트 주식회사 임플란트 표면의 생체활성을 증진시키는 유기용매를 이용한 임플란트 및 그 제조방법
KR101248785B1 (ko) * 2012-04-30 2013-04-03 오스템임플란트 주식회사 초친수성을 갖는 티타늄 임플란트, 그 표면처리 및 보관 방법
KR101404632B1 (ko) * 2013-05-02 2014-06-27 오스템임플란트 주식회사 임플란트의 표면처리방법

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