WO2019054832A2 - Implant dentaire à base de peek présentant une rugosité de surface - Google Patents

Implant dentaire à base de peek présentant une rugosité de surface Download PDF

Info

Publication number
WO2019054832A2
WO2019054832A2 PCT/KR2018/010931 KR2018010931W WO2019054832A2 WO 2019054832 A2 WO2019054832 A2 WO 2019054832A2 KR 2018010931 W KR2018010931 W KR 2018010931W WO 2019054832 A2 WO2019054832 A2 WO 2019054832A2
Authority
WO
WIPO (PCT)
Prior art keywords
peek
dental implant
implant
contour curve
present
Prior art date
Application number
PCT/KR2018/010931
Other languages
English (en)
Korean (ko)
Other versions
WO2019054832A3 (fr
Inventor
박재준
최홍영
Original Assignee
오스템임플란트 주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 오스템임플란트 주식회사 filed Critical 오스템임플란트 주식회사
Publication of WO2019054832A2 publication Critical patent/WO2019054832A2/fr
Publication of WO2019054832A3 publication Critical patent/WO2019054832A3/fr

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0018—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the shape
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
    • A61C8/0016—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy polymeric material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0018—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the shape
    • A61C8/0037—Details of the shape
    • A61C2008/0046—Textured surface, e.g. roughness, microstructure

Definitions

  • the present invention relates to a dental implant, and more particularly, to a dental implant made of PEEK or a composite material containing the PEEK having a certain level of surface roughness.
  • Dental implants inserted into the jawbone for attachment of artificial teeth have been successfully used for a long time.
  • Currently commonly used dental implants are made of titanium or an alloy thereof, which is suitable for living body, has sufficiently low elasticity, and is relatively high in strength.
  • osteo-integration characteristics of dental implants are very important.
  • Good bone fusion characteristics mean that the implant is fixed to the bone to achieve initial stability and then a permanent bond is created between the implant and bone within a short treatment period.
  • the osseointegration characteristic can be obtained by proper treatment of the implant surface.
  • the titanium surface is mechanically roughened by, for example, sandblasting, grinding or etching.
  • the surface may be treated by an additive method such as coating with a textured surface or coating with a biocompatible material.
  • titanium dental implants have a disadvantage that they are inharmonious with the natural teeth because they are dark when the implants are exposed due to gingival recession.
  • the color of the ceramic material may be close to the color of the natural teeth, and efforts have been made to make even a part of the implants observed with the naked eye after the implantation into a ceramic material.
  • ceramic dental implants have low fatigue stability and poor cracking properties.
  • an implant of a polymer material such as polyether ether ketone (PEEK) is advantageous in terms of aesthetics and resistance to cracking, and is partially applied to an orthopedic implant material.
  • PEEK polyether ether ketone
  • the implant of the material has only a surface roughness imparted by mechanical processing for imparting a proper shape, so that there is a problem that the bone fusion and osteogenesis characteristics are lower than those of the conventional titanium implant.
  • the present invention has been made to solve the above-mentioned problems of the prior art, and it is an object of the present invention to provide a dental implant having not only aesthetic, crack resistance but also bone formation characteristics.
  • a dental implant having a blasted and etched surface, wherein the dental implant comprises a polymer, the arithmetic average height (Ra) of the contour curve of the surface is 0.6 to 3.3 m , And an average height (Rc) of the contour curve elements is 2.6 to 15.0 ⁇ ⁇ .
  • the average height of the contour elements may be between 3.0 and 12.0 m.
  • the arithmetic average height of the contour curve may be 0.7-2.
  • the average height Rc of the contour elements may be between 4.5 and 8.5 microns.
  • the arithmetic mean height (Ra) of the outline curve may be 1.1 to 2.5 ⁇ ⁇ .
  • the polymer may be polyetheretherketone (PEEK).
  • the surface of the dental implant according to an aspect of the present invention is a surface of a dental implant which is formed by blasting and etching treatment, and a macro surface (including a first groove) and a micro surface (a second groove (Ra) of the contour curve, and an average height (Rc) of the contour curve elements, thereby providing excellent biocompatibility including bone formation characteristics after implantation .
  • the surface of the dental implant includes a polymer such as polyether ether ketone, it has not only excellent biocompatibility, but also has a color similar to that of a tooth. Therefore, great.
  • FIG. 1 is a diagram illustrating a method of measuring an arithmetic average height Ra of an outline curve and an average height Rc of a contour curve element according to an embodiment of the present invention.
  • FIG. 2 is a schematic view of the surface of a dental implant according to an embodiment of the present invention.
  • PEEK polyetheretherketone
  • PEEK polyetheretherketone
  • PEEK polyetheretherketone
  • FIG. 6 is a SEM image of a surface of a dental implant according to the preparation example of the present invention and the comparative preparation example.
  • FIG. 7 shows the results of measurement of the binding force on the bone interface of the dental implant according to the production example of the present invention and the comparative preparation example.
  • a dental implant having a blasted and etched surface, wherein the dental implant comprises a polymer, the arithmetic average height (Ra) of the contour curve of the surface is 0.6 to 3.3 m , And an average height (Rc) of the contour curve elements is 2.6 to 15.0 ⁇ ⁇ .
  • the dental implant may be composed of a polymer mixture containing polyether ether ketone, or may be composed of polyether ether ketone.
  • FIG. 1 is a diagram illustrating a method of measuring an arithmetic average height Ra of an outline curve and an average height Rc of a contour curve element according to an embodiment of the present invention.
  • the arithmetic average height Ra of the outline curve shown in Fig. 1 (a) is an average value for the center line, and is an average value of the absolute values of the deviations from the center line to the measurement curve.
  • Ra is most widely used as a roughness parameter because it is suitable for evaluation of gloss, surface strength, surface treatment, friction force, electrical contact resistance, etc.
  • exceptional peaks and / or valleys do not affect Ra, Since Ra does not provide information on the roughness type, there is a limitation in specifying the actual shape of the surface roughness of the implant and the physical properties depending thereon.
  • the average height Rc of the contour curve elements shown in Fig. 1 (b) is based on the rule of JIS B 0601 (2001), and is a value obtained by averaging the height of contour curve elements at the reference length lr.
  • the outline curve may include a plurality of peaks and adjacent valleys.
  • said contour curve element is an element whose distance from an adjacent peak or valley is less than 1% of the reference length to noise less than 10% of Rz which is a sum of a maximum value of peak height of said contour curve and a maximum value of valley depth, And points to the remaining element after removing it.
  • the average height Rc of the contour curve elements is a value obtained by averaging the height of the contour curve elements excluding the elements classified by the noise. Since Rc is measured from the contour curve element which is the sum of the peak height and the depth of the valley, the shape of the surface roughness at the reference length and the information resulting therefrom, such as aesthetics, adhesiveness, Can be obtained.
  • Ra and Rc of the surface treated under the same conditions have a similar tendency, but since the information on the surface roughness obtained from Ra and Rc is partly different, both of them are measured and each of them is adjusted to a certain range
  • the desired physical properties can be optimized and implemented.
  • the dental implant has a surface treated by sandblasting and etching, and the arithmetic mean height (Ra) of the outline curve of the surface is 0.6 to 3.3 ⁇ , preferably 0.7 to 2.9 ⁇ , more preferably 1.1 Lt; / RTI >
  • Ra arithmetic mean height
  • the surface structure of the dental implant becomes similar to the natural bone, so that the osseointegration rate on the surface of the implant can be improved, the failure rate after the procedure can be lowered, and the procedure time can be shortened.
  • the average height Rc of the contour curve elements of the surface of the dental implant may be 2.6 to 15.0 m, preferably 3.0 to 12.0 m, and more preferably 4.5 to 8.5 m. Since Ra can not reflect the height and / or depth of an exceptional peak and / or valley, Ra alone can not specify the shape of the surface roughness, and accordingly the physical properties due to the shape of the surface roughness There is a problem that is difficult to achieve. Therefore, by adjusting the range of Ra as well as the range of Rc as described above, it is possible to impart the surface shape and surface roughness of the implant, which is difficult to achieve with only Ra.
  • the surface may include one selected from the group consisting of polymers, ceramics, metals, and combinations of two or more thereof, and may preferably include a polymer.
  • the polymer may be a super engineering plastic, a engineering plastic, a general purpose plastic, or a combination thereof capable of implementing a color similar to teeth, and preferably, it may be polyether ether ketone (PEEK), but is not limited thereto.
  • the dental implant may further include a center portion including one selected from the group consisting of polymers, ceramics, metals, and combinations of two or more thereof.
  • the central portion is not exposed to the outside regardless of before and after the procedure, especially after the procedure, so that the hue is not limited to a tooth-like one.
  • the central portion may be conventional titanium or an alloy thereof, or may be a ceramic such as zirconia.
  • the central portion may comprise a polymer to provide process advantages and to enhance bonding at the surface and core interface.
  • the polymer contained in the central portion may be a super engineering plastic, an engineering plastic, a general purpose plastic, or a combination thereof.
  • the polymer may be polyether ether ketone (PEEK).
  • the surface and the center portion may be fabricated as separate components and then combined to form a dental implant. If necessary, the surface and the center portion may be mechanically processed from one circular shape and then sandblasted and / or etched, A single dental implant in which the central portion is integrally formed may be constituted. Preferably, the dental implant may have the surface and the central portion integrally formed in order to achieve process advantages and to fundamentally block the problem of the bonding force at the surface and the central interface.
  • the surface roughness of the dental implant that is, the arithmetic mean height (Ra) of the outline curve of the above range and the mean height (Rc) of the outline curve element are determined in a dental implant originally made in the form of a dental implant For example, by sandblasting and etching.
  • the polishing means abrasive blasting the surface of the untreated dental implant with an abrasive grain having an average particle diameter of 25 to 1,000 ⁇ m to form a macro surface on the surface.
  • macro surface refers to a structure comprising a first groove formed on the surface by the abrasive particles. The surface area is increased by the effect of the particles sprayed on the surface through the polishing, and the bone interface strengthening effect is increased by the irregular effect and the cell reaction is activated on the rough surface.
  • sand blasting is a method in which a surface of a specific particle is sprayed onto the surface of an implant to form a rough surface.
  • the medium alumina (Al 2 O 3 ), titanium oxide (TiO 2 ), Calcium oxide (Ca 3 PO 4 ), hydroxyapatite (HA), and the like.
  • the ejection pressure of the medium may be 2.0 to 5.0 MPa, preferably 2.5 to 4.5 MPa, more preferably 2.5 to 4.0 MPa, and the ejection time of the medium may be 1 to 60 seconds, 60 seconds.
  • the implant may be immersed in an acid aqueous solution, for example, an aqueous nitric acid solution, at a predetermined concentration to remove the medium remaining on the surface after spraying the medium.
  • micro surface can be formed on the macro surface by treating the macro surface formed on the surface of the dental implant by the polishing with an etching solution.
  • micro-surface means a structure including a second groove smaller in size than the first groove formed on the macro surface.
  • the etchant may comprise a permanganic acid compound.
  • the permanganic acid compound may be an alkali metal salt, and preferably, it may be a sodium salt or a potassium salt.
  • the content of the permanganic acid compound in the etching solution may be 0.001 to 20 wt%, preferably 0.01 to 10 wt%, more preferably 0.1 to 5 wt%.
  • the etching solution may become alkaline due to the influence of counter ions. Since the alkaline etching solution adversely affects the surface of the implant, it is preferable to add a certain amount of acid to the etching solution to maintain the acidity.
  • the acid which can be used in combination with the permanganic acid compound in the etching solution may be an organic acid or an inorganic acid, preferably an inorganic acid.
  • the organic acid may be, for example, formic acid, acetic acid, propionic acid or the like, preferably acetic acid, but is not limited thereto.
  • the inorganic acid may be, for example, phosphoric acid, nitric acid, sulfuric acid and the like, preferably phosphoric acid, but is not limited thereto.
  • the content of the acid in combination with the permanganic acid compound in the etching solution may be 1 to 50 wt%, preferably 5 to 25 wt%.
  • the etchant may contain residual water in addition to the permanganic acid compound and an acid used in combination with the permanganic acid compound, and the temperature of the etchant may be adjusted to room temperature (about 25 ° C) during etching.
  • FIG. 2 is a schematic view of the surface of a dental implant according to an embodiment of the present invention.
  • a macroscopic surface including a first groove may be formed on the surface of the dental implant by the polishing, and a plurality of grooves may be formed on the surface of the dental implant, 2 < / RTI > grooves.
  • Ra and Rc of the above range can be realized, thereby improving osseointegration and bone formation characteristics including biocompatibility after the implant treatment.
  • a polyether ether ketone (PEEK) round specimen was mechanically processed to prepare a disc (cylindrical) specimen having a diameter of 6 mm and a thickness of 2 mm.
  • a polyetheretherketone (PEEK) specimen in the form of a disk (cylinder) having a diameter of 6 mm and a thickness of 2 mm was prepared and a hydroxyapatite (HA) powder having an average particle diameter of 0.5 mm on the surface was pressed at a pressure of 10 to 60 Lt; / RTI > After the spraying, a first groove (macroscopic surface) was formed on the surface of the specimen by immersing in a nitric acid aqueous solution having a concentration of 15% by weight for 2 seconds in order to remove the hydroxyapatite powder from the surface of the specimen.
  • PEEK polyetheretherketone
  • the test piece having the first grooves formed in Example 1 was immersed in an aqueous acid solution containing 2 wt% of potassium permanganate (KMnO 4 ), 10 wt% of phosphoric acid (H 3 PO 4 ) and a remaining amount of water at room temperature (about 25 ° C) And a second groove (micro-surface) smaller in size than the first groove was formed on the surface of the specimen by soaking for 1.5 minutes.
  • aqueous acid solution containing 2 wt% of potassium permanganate (KMnO 4 ), 10 wt% of phosphoric acid (H 3 PO 4 ) and a remaining amount of water at room temperature (about 25 ° C)
  • a second groove (micro-surface) smaller in size than the first groove was formed on the surface of the specimen by soaking for 1.5 minutes.
  • the surface of the PEEK specimen was treated in the same manner as in Example 2 except that hydroxyapatite (HA) powder was sprayed at a pressure of 3.0 MPa.
  • HA hydroxyapatite
  • the surface of the PEEK specimen was treated in the same manner as in Example 2 except that hydroxyapatite (HA) powder was sprayed at a pressure of 3.5 MPa.
  • HA hydroxyapatite
  • the surface of the PEEK specimen was treated in the same manner as in Example 2 except that hydroxyapatite (HA) powder was sprayed at a pressure of 4.0 MPa.
  • HA hydroxyapatite
  • the surface of the PEEK specimen was treated in the same manner as in Example 2 except that hydroxyapatite (HA) powder was sprayed at a pressure of 4.5 MPa.
  • HA hydroxyapatite
  • the surface roughness of the specimen was measured with a contact type roughness tester (FTSS S5, Taylor Hobson Ltd, UK). For this purpose, two specimens were randomly selected in each of the comparative examples and the examples, and three different specimens were measured. The measurement length and cutoff length were measured to be 2 mm and 0.025 mm, respectively, and the results were obtained using Gaussian filtering.
  • FIG. 3 shows the measurement results of the surface roughness of polyetheretherketone (PEEK) specimens according to Examples and Comparative Examples of the present invention.
  • PEEK polyetheretherketone
  • Example 4 is a SEM image of a surface of a polyetheretherketone (PEEK) specimen according to an embodiment of the present invention and a comparative example. Referring to FIG. 4, the surface roughness of Example 6 was significantly increased as compared with the comparative example, and the results are also consistent with the measured values of Ra and Rc.
  • PEEK polyetheretherketone
  • the surface of the PEEK specimen was treated in the same manner as in Example 6 except that the content of potassium permanganate (KMnO 4) in the aqueous acid solution was changed to 4 wt%.
  • the surface of the PEEK specimen was treated in the same manner as in Example 6 except that the content of potassium permanganate (KMnO 4) in the aqueous acid solution was changed to 5 wt%.
  • the surface of the PEEK specimen was treated in the same manner as in Example 6 except that the content of potassium permanganate (KMnO 4) in the aqueous acid solution was changed to 6 wt%.
  • Example 5 is an image obtained by a non-contact measurement method for the surface of a polyetheretherketone (PEEK) specimen according to an embodiment of the present invention. 5, only the macroscopic surface (blue region) due to polishing was observed in Example 1. On the other hand, in Examples 2 to 6, a micro surface (red region) formed by etching was formed on the macro surface formed by polishing, Were observed.
  • PEEK polyetheretherketone
  • a PEEK implant (untreated) having an untreated surface was prepared using the method of the above comparative example.
  • 6 is a SEM image of a surface of a dental implant according to the preparation example of the present invention and the comparative preparation example. 6, a large number of unnecessary protruding burrs were observed on the surface of the polished PEEK implant in the comparative production example, whereas on the surface of the polished and etched PEEK implant in the manufacturing example, these burrs were substantially completely removed .

Landscapes

  • Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dentistry (AREA)
  • Engineering & Computer Science (AREA)
  • Ceramic Engineering (AREA)
  • Plastic & Reconstructive Surgery (AREA)
  • Dental Prosthetics (AREA)

Abstract

Selon un mode de réalisation, la présente invention concerne un implant dentaire dont la surface est décapée et gravée, où l'implant dentaire comprend une polyéther éther cétone, la Ra du profil de la surface est de 0,6 à 3,3 µm, et le Rc des éléments de profil de la surface est de 2,6 à 15,0 µm.
PCT/KR2018/010931 2017-09-18 2018-09-17 Implant dentaire à base de peek présentant une rugosité de surface WO2019054832A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020170119652A KR20190031783A (ko) 2017-09-18 2017-09-18 표면거칠기를 가지는 치과용 임플란트
KR10-2017-0119652 2017-09-18

Publications (2)

Publication Number Publication Date
WO2019054832A2 true WO2019054832A2 (fr) 2019-03-21
WO2019054832A3 WO2019054832A3 (fr) 2019-05-16

Family

ID=65723386

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2018/010931 WO2019054832A2 (fr) 2017-09-18 2018-09-17 Implant dentaire à base de peek présentant une rugosité de surface

Country Status (2)

Country Link
KR (1) KR20190031783A (fr)
WO (1) WO2019054832A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102560659B1 (ko) * 2021-07-19 2023-07-28 오스템임플란트 주식회사 치과용 임플란트의 표면처리 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1598028B1 (fr) * 2004-05-19 2007-12-12 Straumann Holding AG Implant dentaire monobloc et son procédé de fabrication
DE102011116289B4 (de) * 2011-10-19 2015-02-26 Heraeus Precious Metals Gmbh & Co. Kg Verfahren zur Herstellung einer implantierbaren Vorrichtung mit Isolierungsschicht
US10806831B2 (en) * 2012-05-09 2020-10-20 Sintx Technologies, Inc. Antibacterial biomedical implants and associated materials, apparatus, and methods
KR101861343B1 (ko) * 2014-11-28 2018-05-29 주식회사 바이오알파 히드록시아파타이트로 표면을 수식한 폴리에테르에테르케톤
KR101724039B1 (ko) * 2016-05-18 2017-04-06 한국전기연구원 나노패터닝 요홈 표면을 갖는 임플란트 및 그 제조방법

Also Published As

Publication number Publication date
WO2019054832A3 (fr) 2019-05-16
KR20190031783A (ko) 2019-03-27

Similar Documents

Publication Publication Date Title
US20100081109A1 (en) Dental implant and method for the production thereof
AU2008201488A1 (en) Process for providing a topography to the surface of a dental implant
CN108658628B (zh) 一种氧化锆修复体与天然牙粘接结合的方法
Valian et al. Surface treatment of feldspathic porcelain: scanning electron microscopy analysis
WO2007102143A2 (fr) Procédé de fabrication de métal à revêtement céramique
WO2017185475A1 (fr) Procédé de traitement de surface pour implants dentaires en zircone
WO2019054832A2 (fr) Implant dentaire à base de peek présentant une rugosité de surface
WO2016167476A1 (fr) Implant ayant une surface de structure composite de taille micrométrique et nanométrique, et procédé de traitement de surface d'implant
CN110584803A (zh) 一种3d打印氧化锆修复体及其制备方法以及其与牙体的粘接方法
CN110753560B (zh) 牙科植入物
Oh et al. Surface characteristics of bioactive glass-infiltrated zirconia with different hydrofluoric acid etching conditions
KR101652968B1 (ko) 하이브리드 타입으로 표면처리된 임플란트용 픽스츄어
Richard Innovative surface treatments of titanium alloys for biomedical applications
KR101460974B1 (ko) 표면이 코팅되어 생체 적합성이 향상된 치과용 임플란트 및 이의 제조 방법
WO2012171535A1 (fr) Technique de traitement de surface de zircone pré-frittée pour appareils dentaires
KR101460976B1 (ko) 표면이 코팅되어 생체 친화성이 향상된 치과용 임플란트 및 이의 제조 방법
CN115141038A (zh) 一种增强粘接能力的氧化锆陶瓷粘接面改性方法
KR20200016310A (ko) 표면거칠기를 가지는 peek계 치과용 임플란트
WO2016006889A1 (fr) Implant dentaire à revêtement de surface présentant une bioaffinité et une biocompatibilité améliorées et procédé de fabrication associé
KR100449902B1 (ko) 치과용 임프란트의 표면 처리 방법
KR101376128B1 (ko) 세라믹 코팅한 소아 보철용 에스에스크라운
Alkhudhairy Microtensile and microshear bond strength of cemented ceramics using self-etching primer versus conventional surface treatment
Mario Surface Treatment of Lithium Disilicate with Different Concentrations of Hydrofluoric Acid and Orthophosphoric Acid
EP1579875A1 (fr) Implant fabriqué de titane ou alliage de titane et son procède de traitement de surface
Darvizeh et al. In-situ nano-silica deposition and air-abrasion with Bioglass 45S5 or aluminium oxide: Effects on methacrylate bonding to yttria-tetragonal zirconia polycrystal

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 18856794

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 18856794

Country of ref document: EP

Kind code of ref document: A2