WO2015139564A1

WO2015139564A1 - A fungicidal composition comprising strobilurin fungicides and triazole fungicides

Info

Publication number: WO2015139564A1
Application number: PCT/CN2015/073751
Authority: WO
Inventors: James Timothy Bristow; Yifan Wu
Original assignee: Rotam Agrochem International Company Limited
Priority date: 2014-03-18
Filing date: 2015-03-06
Publication date: 2015-09-24

Abstract

The present invention also related to a fungicidal composition comprising components (A) at least one strobilurin fungicides and (B) at least one triazole fungicides. The present invention also related to a method to prevent and/or treat fungal infestations in plants and plant parts by applying a fungicidal composition comprising components (A) at least one strobilurin fungicides and (B) at least one triazole fungicides.

Description

A FUNGICIDAL COMPOSITION COMPRISING STROBILURIN FUNGICIDES AND TRIAZOLE FUNGICIDES

The present invention relates to a fungicidal composition comprising components (A) strobilurin fungicides and (B) triazole fungicides. The present invention also related to a method to prevent and/or treat fungal infestations in plants and plant parts by applying a fungicidal composition comprising components (A) strobilurin fungicides and (B) triazole fungicides.

BACKGROUND

Fungal diseases represent a major threat to economically important agricultural crops, like cereals, fruits and vegetables. The yield of plants, for example, grape, apple, tomato and rice, are adversely impacted by fungal diseases. Powdery mildew of grape, caused by the fungus Uncinula necator, may cause a reduction of berry size and sugar content. Scarring and cracking of berries may be so severe as to make fruit unsuitable for any purpose. Apple scab, caused by the ascomycete fungus Venturia inaequalis, may cause more than 70％loss in yield where humid, cool weather if it is not controlled. Powdery mildew of tomato, caused by the fungus Leveillula taurica, may cause more than 50％yield loss in heavily infected fields. Rice Blast of rice, caused by Magnaporthe oryzae (anamorph: Pyricularia oryzae) , may cause more than 40％yield loss. It was reported that this disease caused about 75％loss grains in India. (Padmanabhan, S. Y. (1965) Estimating losses from rice blast in India. In the rice blast disease: Johan Hopkins Press, Baltinoie, Maryland. 203-221. ) Therefore, there is a continuing need to provide a fungicidal composition for controlling fungal pathogens, thereby increasing the yield of plant.

Strobilurin or strobilurin-type fungicides are a well-known class of fungicides with a broad spectrum of disease control. They are extracted from the fungus Strobilurus tenacellus. They have a suppressive effect on other fungi, reducing competition for nutrients； they inhibit electron transfer between cytochrome b and cytochrome C₁ at the ubiquinol oxidising site in mitochondria, disrupting metabolism and preventing growth of the target fungi. Examples of strobilurins are fluoxastrobin, mandestrobin, azoxystrobin, bifujunzhi, coumoxystrobin, enoxastrobin, flufenoxystrobin, jiaxiangjunzhi, picoxystrobin, pyraoxystrobin, pyraclostrobin, pyrametostrobin, triclopyricarb, dimoxystrobin, fenaminstrobin, metominostrobin, orysastrobin, kresoxim-methyl, trifloxystrobin, famoxadone and fenamidone.

However, experience with the strobilurin fungicides worldwide indicates there is a high risk of development of resistant pathogen subpopulations. Resistance has been reported worldwide in an increasing number of pathogens of field crops, fruit, vegetable, and so on (Vincelli, P. 2002. Q_oI (Strobilurin) Fungicides: Benefits and Risks. The Plant Health Instructor. DOI: 10.1094/PHI-I-2002-0809-02. Updated, 2012. ) . As suggested in Vincelli, P. 2002, mixing the strobilurin fungicides with other fungicides can reduce selection pressure towards resistance.

Triazoles are a class of systemic fungicides that enter the plant and spread from the site of application to untreated or newly grown area, uprooting existing fungi or protecting the plant from future attacks. The mechanism of action of these fungicides is due to their ability to interfere with the biosynthesis of biosteroids or to inhibit the biosynthesis of ergosterol. Ergosterol is needed for membrane structure and function. It is essential for the development of functional cell walls by fungi. Therefore, application of triazoles results in abnormal fungal growth and eventually death. Examples of triazoles are azaconazole, bromuconazole, cyproconazole, diclobutrazol, difenoconazole, diniconazole, diniconazole-M, epoxiconazole, etaconazole, fenbuconazole, fluquinconazole, flusilazole, flutriafol, furconazole, furconazole-cis, hexaconazole, imibenconazole, ipconazole, metconazole, myclobutanil, penconazole, propiconazole, prothioconazole, quinconazole, simeconazole, tebuconazole, tetraconazole, triadimefon , triadimenol, triticonazole, uniconazole, amitrol, bitertanol, climbazole, clotrimazole, fluotrimazole, paclobutrazol, triazbutil and 1- (4-fluorophenyl) -2- (1H-1, 2, 4-triazole-1-yl)ethanone.

Therefore, it would be advantageous to provide a fungicidal composition comprising components (A) strobilurin fungicides and (B) triazole fungicides, which is susceptible to fungal diseases caused by fungal pathogens or surrounding, according to the present invention.

SUMMARY OF THE INVENTION

The present invention relates to a fungicidal composition comprising components (A) at least one strobilurin fungicides and (B) at least one triazole fungicides. The present invention also related to a method to prevent and/or treat fungal infestations in plants and plant parts by applying a fungicidal composition comprising components (A) at least one strobilurin fungicides and (B) at least one triazole fungicides on the plants, plant parts and surrounding.

The invention also relates to a plant treated with a composition hereinbefore defined, either before infestation by a fungus or treated to combat an existing fungal infection.

"Plant" as used herein, refers to all plant and plant populations such as desired and undesired wild plants or crop plants.

"Plant parts" as used herein, refers to all parts and organs of plants, such as shoot, leaves, needles, stalks, stems, fruit bodies, fruits, seeds, roots, tubers and rhizomes. Harvested materials, and vegetative and generative propagation materials, for example, cutting, tubers, meristem tissue, rhizomes, offsets, seeds, single and multiple plant cells and any other plant tissues, are also included.

The word “surrounding” refers to the place on which the plants are growing, the place on which the plant propagation materials of the plants are sown or the place on which the plant propagation materials of the plants will be sown.

“At least one” designates a number of the respective compounds of 1, 2, 3, 4, 5, 6, 7, 8, 9 or more, preferably 1, 2, or 3.

It has now surprisingly been found that when applying a fungicidal composition comprising components (A) at least one strobilurin fungicides and (B) at least one triazole fungicides on the plants, plant parts or surrounding, particularly on grape, apple, tomato and rice, an excellent performance in preventing and treating fungal infestations may be observed.

The components (A) and (B) may be applied in any desired sequence, any combination, consecutively or simultaneously.

The component (A) strobilurin fungicides may be present in the composition of the present invention in any suitable amount, and is generally present in an amount of from 1％to 75％by weight of the composition, preferably from 1％to 50％by weight of the composition, more preferably from 3％to 20％by weight of the composition.

The component (A) strobilurin fungicides may be any fungicidally active strobilurin compounds, for example with such compounds being known in the art and commercially available. The strobilurin compound is preferably one or more selected from fluoxastrobin, mandestrobin, azoxystrobin, bifujunzhi, coumoxystrobin, enoxastrobin, flufenoxystrobin, jiaxiangjunzhi, picoxystrobin, pyraoxystrobin, pyraclostrobin, pyrametostrobin, triclopyricarb, dimoxystrobin, fenaminstrobin, metominostrobin, orysastrobin, kresoxim-methyl, trifloxystrobin, famoxadone and fenamidone. In some embodiments, the strobilurin fungicide is selected from the group consisting of azoxystrobin, picoxystrobin, pyraclostrobin and combinations thereof. In certain embodiments, the strobilurin fungicide is azoxystrobin.

The component (B) triazole fungicides may be present in the composition in any suitable amount, and is generally present in an amount of from 1％to 70％by weight of the composition, preferably from 2％to 50％by weight of the composition, more preferably from 10％to 25％by weight of the composition.

The component (B) triazole fungicides may be any fungicidally active triazole compounds, for example with such compounds being known in the art and available commercially. The triazole compound is preferably one or more selected from azaconazole, bromuconazole, cyproconazole, diclobutrazol, difenoconazole, diniconazole, diniconazole-M, epoxiconazole, etaconazole, fenbuconazole, fluquinconazole, flusilazole, flutriafol, furconazole, furconazole-cis, hexaconazole, imibenconazole, ipconazole, metconazole, myclobutanil, penconazole, propiconazole, prothioconazole, quinconazole, simeconazole, tebuconazole, tetraconazole, triadimefon, triadimenol, triticonazole, uniconazole, amitrol, bitertanol, climbazole, clotrimazole, fluotrimazole, paclobutrazol, triazbutil and 1- (4-fluorophenyl) -2- (1H-1, 2, 4-triazole-1-yl)ethanone. In some embodiments, the triazole fungicide is selected from the group consisting of azaconazole, cyproconazole, difenoconazole, flutriafol, metconazole, propiconazole, tebuconazole and combinations thereof. In certain embodiments, the triazole fungicide is cyproconazole, flutriafol or tebuconazole and combinations thereof. In certain embodiments, the triazole fungicide is tebuconazole.

The components (A) and (B) may be present in the composition or applied in any amounts relative to each other, to provide the enhanced or synergistic effect of the mixture. In particular, the weight ratio of the components (A) and (B) in the composition independently is preferably in the range of from 25: 1 to 1: 25, 20: 1 to 1: 20, or 15: 1 to 1: 15, more preferably 10: 1 to 1: 10, 5: 1 to 1: 5 or 2: 1 to 1: 2. In some embodiments, the weight ratio of the components (A) and (B) in the composition independently is 1: 2.

The components (A) and (B) together may be present in the composition in any suitable amount, and is generally present in an amount of from 2％to 95％by weight of the composition, preferably from 10％to 60％by weight of the composition more preferably from 20％to 40％by weight of the composition.

In a preferred embodiment of the invention, each combination is a composition comprising, components (A) and (B) , and optionally one or more auxiliaries. The auxiliaries employed in the composition will depend upon the type of formulation and/or the manner in which the formulation is to be applied by the end user. Formulations incorporating the composition of the present invention are described hereinafter. Suitable auxiliaries which may be comprised in the composition according to the invention are all customary formulation adjuvants or components, such as extender, carriers, solvents, surfactants, stabilizers, anti-foaming agents, anti-freezing agents, preservatives, antioxidants, colorants, thickeners, solid adherents and inert fillers. Such auxiliaries are known in the art and are commercially available. Their use in the formulation of the compositions of the present invention will be apparent to the person skilled in the art.

The fungicidal composition may further comprise one or more inert fillers. Such inert fillers are known in the art and available commercially. Suitable fillers include, for example, natural ground minerals, such as kaolins, aluminas, talc, chalk, quartz, attapulgite, montmorillonite, and diatomaceous earth, or synthetic ground minerals, such as highly dispersed silicic acid, aluminum oxide, silicates, and calcium phosphates and calcium hydrogen phosphates. Suitable inert fillers for granules include, for example, crushed and fractionated natural minerals, such as calcite, marble, pumice, sepiolite, and dolomite, or synthetic granules of inorganic and organic ground materials, as well as granules of organic material, such as sawdust, coconut husks, corn cobs, and tobacco stalks.

The fungicidal composition optionally includes one or more surfactants which are preferably non-ionic, cationic and/or anionic in nature and surfactant mixtures which have good emulsifying, dispersing and wetting properties, depending on the nature of the active compound to be formulated. Suitable surfactants are known in the art and are commercially available. Suitable anionic surfactants can be both so-called water-soluble soaps and water-soluble synthetic surface-active compounds. Soaps which may be used are the alkali metal, alkaline earth metal or substituted or unsubstituted ammonium salts of higher fatty acid (C₁₀-C₂₂) , for example the sodium or potassium salt of oleic or stearic acid, or of natural fatty acid mixtures. The surfactant can be an emulsifier, dispersant or wetting agent of ionic or nonionic type. Examples which may be used are salts of polyacrylic acids, salts of lignosulphonic acid, salts of phenylsulphonic or naphthalenesulphonic acids, polycondensates of ethylene oxide with fatty alcohols or with fatty acids or with fatty amines, substituted phenols, especially alkylphenols, sulphosuccinic ester salts, taurine derivatives, especially alkyltaurates, or phosphoric esters of polyethoxylated phenols or alcohols. The presence of at least one surfactant is generally required when the active compound and/or the inert carrier and/or auxiliary/adjuvant are insoluble in water and the vehicle for the final application of the composition is water.

The fungicidal composition optionally further comprises one or more polymeric stabilizer. The suitable polymeric stabilizers that may be used in the present invention include, but are not limited to, polypropylene, polyisobutylene, polyisoprene, copolymers of monoolefins and diolefins, polyacrylates, polystyrene, polyvinyl acetate, polyurethanes or polyamides. Suitable stabilizers are known in the art and commercially available.

The surfactants and polymeric stabilizers mentioned above are generally believed to impart stability to the composition, in turn allowing the composition to be formulated, stored, transported and applied.

Suitable anti-foams include all substances which can normally be used for this purpose in agrochemical compositions. Suitable anti-foam agents are known in the art and are available commercially. Particularly preferred antifoam agents are mixtures of polydimethylsiloxanes and perfluroalkylphosphonic acids, such as the silicone anti-foam agents available from GE or Compton.

Suitable organic solvents are selected from all customary organic solvents which thoroughly dissolve the active compounds employed. Again, suitable organic solvents for the active components (A) and (B) are known in the art. The following may be mentioned as being preferred: N-methyl pyrrolidone, N-octyl pyrrolidone, cyclohexyl-1-pyrrolidone； or SOLVESSO^TM200, a mixture of paraffinic, isoparaffinic, cycloparaffinic and aromatic hydrocarbons. Suitable solvents are commercially available.

Suitable preservatives include all substances which can normally be used for this purpose in agrochemical compositions of this type and again are well known in the art. Suitable examples that may be mentioned include

(from Bayer AG) and

(from Bayer AG) .

Suitable antioxidants are all substances which can normally be used for this purpose in agrochemical compositions, as is known in the art. Preference is given to butylated hydroxytoluene.

Suitable thickeners include all substances which can normally be used for this purpose in agrochemical compositions. For example xanthan gum, PVOH, cellulose and its derivatives, clay hydrated silicates, magnesium aluminum silicates or a mixture thereof. Again, such thickeners are known in the art and available commercially.

The fungicidal composition may further comprise one or more solid adherents. Such adherents are known in the art and available commercially. They include organic adhesives, including tackifiers, such as celluloses of substituted celluloses, natural and synthetic polymers in the form of powders, granules, or lattices, and inorganic adhesives such as gypsum, silica, or cement.

In addition, depending upon the formulation, the composition according to the invention may also comprise water.

In some embodiments, compositions according to the present invention comprise the following combinations of components:

(A) azoxystrobin, (B) cyproconazole；

(A) azoxystrobin, (B) flutriafol； or

(A) azoxystrobin, (B) tebuconazole.

According to a preferred embodiment, the fungicidal composition according to the present invention comprises components (A) azoxystrobin and (B) tebuconazole.

Each of the compositions of the present invention can be used in the agricultural sector and related fields of use for preventing and/or treating diseases caused by fungal pathogens for example, but not limited to:

· Uncinula necator (Powdery mildew) on grape；

· Venturia inaequalis (Apple scab) on apple；

· Leveillula taurica (Powdery mildew) on tomato； and

· Magnaporthe oryzae (anamorph: Pyricularia oryzae) (Rice Blast) , on rice； Complejo de Manchado del grano (Sarocladium oryzae, Alternaria sp, Rynchosporium oryzae, Cercospora oryzae and Helminthosporium sp) on rice； Rhizocthonia solani (Rice blast) ； Helminthosporium oryzae (Spotted grain) on rice；

· Phakopsora pachyrhizi (Asian soybean rust) , Cercospora kikuchi (Cercospora leaf blight) , Cercospora sojina (Frogeye leaf spot) , Septoria glycines (Brown spot) on soybean；

· Drechslera tritici-repenti (tan spot) , Puccinia triticina (Leaf rust) , Septoria tritici (septoria leaf blotch) on wheat；

· Mildeo Polvoso Sphaerotheca pannosa on rose；

· Puccinia recondita (Brown rust) ； Puccinia graminis (Stem rust) ； Puccinia striiformis (Yellow rust) ； Septoria spp. (Leaf spot) on wheat；

· Puccinia hordei (Brown rust) ； Pyrenophora teres (Net blotch) ； Rhynchosporium secalis (Leaf scald or blotch) on barley；

· Uromyces spp (Rust) ； Botrytis cinerea (Botrytis) ； Powdery mildew, Downy mildew, Ascochyta, Colletotrichum lindemuthianum (Anthracnose) on beans； and

· Leaf rust on maize.

The fungal disease to be treated and/or prevented may be selected from the group comprising powdery mildew, apple scab and rice blast rust.

The composition in the present invention exhibits surprisingly high effectiveness in treating and/or preventing fungal diseases caused by fungal pathogens, particularly Uncinula necator, Venturia inaequalis, Leveillula taurica and Magnaporthe oryzae (anamorph: Pyricularia oryzae) , more particularly Uncinula necator.

The composition according to the present invention is suitable for plants of the crops: cereals (wheat, barley, rye, oats, corn, rice, sorghum, triticale and related crops) ； beet (sugar beet and fodder beet) ； fruit, such as pomes, stone fruit and soft fruit, such as apples, grapes, pears, plums, peaches, almonds, cherries, and berries, for example strawberries, raspberries and blackberries； leguminous plants (beans, lentils, peas, soybeans) ； oil plants (rape, mustard, sunflowers) ； cucurbitaceae (marrows, cucumbers, me0ons) ； fibre plants (cotton, flax, hemp, jute) ； citrus fruit, such as oranges, lemons, grapefruit and mandarins； vegetables (spinach, lettuce, asparagus, cabbages, carrots, onions, tomatoes, potatoes, paprika) ； as well as ornamentals (flowers, such as rose, shrubs, broad-leaved trees and evergreens, such as conifers) . In certain embodiments, the composition of the present invention is applied on cereals, fruits and vegetables. In some embodiments, the composition of the present invention is applied on apple, grape, tomato and rice. In another embodiments, the composition of the present invention is applied on grape.

The composition is particular effective in preventing and/or treating Uncinula necator of grape and its plant parts by applying a fungicidal composition comprising components (A) strobilurin fungicides and (B) triazole fungicides.

The composition is particular effective in preventing and/or treating Uncinula necator of grape and its plant parts by applying a fungicidal composition comprising components (A) strobilurin fungicides and (B) triazole fungicides, wherein the weight ratio of the components (A) and (B) in the composition is 1: 2.

The composition is particular effective in preventing and/or treating Uncinula necator of grape and its plant parts by applying a fungicidal composition comprising components (A) azoxystrobin and (B) tebuconazole, wherein the weight ratio of the components (A) and (B) in the composition is 1: 2.

The composition is particular effective in preventing and/or treating Uncinula necator of grape and its plant parts by applying a fungicidal composition comprising components (A) azoxystrobin and (B) tebuconazole, wherein the weight of the component (A) is 8％by weight of the composition and； wherein the component (B) is 16％by weight of the composition.

The composition comprising components (A) strobilurin fungicides and (B) triazole fungicides is used to prevent and/or treat fungal infestations in plants and plant parts. The composition comprising components (A) azoxystrobin and (B) tebuconazole is used to prevent and/or treat Uncinula necator of grape and its plant parts.

Each of the compositions can be applied to the foliage of the plant.

The composition of the present invention may contain or be mixed with other pesticides, such as other fungicides, insecticides and nematicides, growth factor and fertilizers.

The rates of application (use) of the composition of the present invention may vary, for example, according to type of use, type of crop, the specific active compounds in the combination, type of plants, but is such that the active compounds in the combination in an effective amount to provide the desired action (such as disease or pest control) . The application rate of the composition for a given set of conditions can readily be determined by trials.

The components (A) and (B) , and any other pesticides, may be applied and used in pure form, as a solid active compound, for example, in a specific particle size, or preferably together with at least one of the auxiliary or adjuvant components, as is customary in formulation technology, such as extenders, for example solvents or solid carriers, or surface-active compounds (surfactants) , as described in more detail above. Generally, the components (A) and (B) are in the form of a formulation composition with one or more of the aforementioned customary formulation auxiliaries.

Examples of formulation types for pre-mix compositions are:

water-soluble concentrate (SL) , an emulstifiable concentrate (EC) , an emulsion (EW) , a micro-emulsion (ME) , a suspension concentrates (SC) , an oil-based suspension concentrates (OD) , a flowable suspension (FS) , a water-dispersible granule (WG) , water-soluble granule (SG) , a water-dispersible powder (WP) , a water soluble powder (SP) , a granule (GR) , an encapsulated granule (CG) , a fine granule (FG) , a macrogranule (GG) , an aqueous suspo-emulsion (SE) , capsule suspension (CS) and a microgranule (MG) .

Using such formulations, either straight (that is undiluted) or diluted with a suitable solvent, especially water, plants, plant parts and/or the surrounding can be treated and protected against damage, for example by pathogen (s) , by spraying, pouring or immersing. In some embodiments, the composition is suspension concentrate. For suspension concentrate formulation, the composition can be diluted with water having the rate of 50-500 mL of composition in 100 L of water. For suspension concentrate formulation applied on grape, the composition can be diluted with water having a concentration of 50-150 mL of composition in 100 L of water, more preferably 100 mL of the composition in 100 L of water.

The composition can be applied with the methods known in the art. These methods include coating, spraying, dipping, soaking, injection and irrigation etc.

The active components (A) and (B) can be applied to the plants, plant parts and/or surrounding where control is desired either simultaneously or in succession at short intervals, for example on the same day. The components (A) and (B) may be applied to the plant, one or more parts thereof (such as leaves or seeds) , or surrounding in any order. Each compound may be applied just once or a plurality of times. Preferably, each of the components (A) and (B) are applied a plurality of times, in particular from 2 to 5 times, more preferably 3 times.

The active components (A) and (B) may be applied in any suitable form, as described above. Typically, the active components will be applied as formulations, that is compositions comprising one or more of the active components together with further carriers, surfactants or other application-promoting adjuvants customarily employed in formulation technology.

In the event compounds (A) and (B) are applied simultaneously in the present invention, they may be applied as a composition containing components (A) and (B) , in which case components (A) and (B) can be obtained from a separate formulation source and mixed together (known as a tank-mix, ready-to-apply, spray broth, or slurry) , optionally with other pesticides, or components (A) and (B) can be obtained as a single formulation mixture source (known as a pre-mix, concentrate, formulated compound (or product) ) , and optionally mixed together with other pesticides.

The compositions according to the invention are distinguished by the fact that they are especially well tolerated by plants and are environmentally friendly.

Each composition according to the invention is especially advantageous for the treatment of plants.

The following examples are given by way of illustration and not by way of limitation of the invention.

FORMULATION EXAMPLES

Example 1

An aqueous suspension concentrate was prepared having the following composition:

The finely ground azoxystrobin and cyproconazole were intimately mixed with the adjuvants, giving a suspension concentrate from which suspensions of any desired dilution could be obtained by dilution with water. As an alternative, a suspension of azoxystrobin and cyproconazole and auxiliaries (including water) was wet milled with a bead-mill to achieve a stable formulation with appropriate treatment characteristics.

Example 2

The finely ground azoxystrobin and flutriafol were intimately mixed with the auxiliaries, giving a suspension concentrate from which suspensions of any desired dilution could be obtained by dilution with water. As an alternative, a suspension of azoxystrobin and flutriafol and auxiliaries (including water) was wet milled with a bead-mill to achieve a stable formulation and with the appropriate treatment characteristics.

Example 3

The finely ground azoxystrobin and tebuconazole were intimately mixed with the auxiliaries, giving a suspension concentrate from which suspensions of any desired dilution could be obtained by dilution with water. As an alternative, a suspension of azoxystrobin and tebuconazole and auxiliaries (including water) was wet milled with a bead-mill to achieve a stable formulation and with the appropriate treatment characteristics.

Example 4

An emulsifiable concentrate was prepared having the following composition:

Example 5

A suspo-emulsion was prepared having the following composition:

Tebuconazole was mixed with N-methyl pyrrolidone and the emulsifiers OR/36 and polymeric stabilizer polyurethanes to get an oil phase. The finely ground azoxystrobin was intimately mixed with the other auxiliaries (including water) , giving a water phase. As an alternative, a suspension of the azoxystrobin and auxiliaries (including water) was wet milled with a bead-mill to achieve a water phase. The oil phase was added to water phase under continuous agitation for an optimum amount of time.

Example 6

An oil-based suspension concentrate was prepared having the following composition:

The finely ground azoxystrobin and cyproconazole were intimately mixed with the auxiliaries, giving a suspension concentrate from which suspensions of any desired dilution could be obtained by dilution with water.

Example 7

A water-dispersible granule was prepared having the following composition:

With the water-dispersible granule, an aqueous suspension of required concentration was obtained through dilution of the water dispersible granule with an appropriate amount of water.

Biological Examples

· Field Test 1-Grape

Young grape plants were sprayed with a conidial suspension of Uncinula necator, and incubated at 20 ℃ and 100 ％relative atmospheric humidity for 48 hours. The Formulations Examples were diluted 1000 times and then sprayed on the plants until ran-off. After staying in a greenhouse at 15 ℃ and 80 ％relative atmospheric humidity for 15 days, severity of the plants were examined.

The results of the assessment are set out in Table A below.

Table A:

Field Test 2 –Apple

Young apple plants were sprayed with a conidial suspension of Venturia inaequalis, and incubated at 20 ℃ and 100 ％relative atmospheric humidity for 48 hours. The Formulations Examples were diluted 1000 times and then sprayed on the plants until ran-off. After staying in a greenhouse at 15 ℃ and 80 ％relative atmospheric humidity for 15 days, severity of the plants were examined.

Table B:

Field Test 3 –Tomato

Young tomato plants were sprayed with a conidial suspension of Leveillula taurica, and incubated at 20 ℃ and 100 ％relative atmospheric humidity for 48 hours. The Formulations Examples were diluted 1000 times and then sprayed on the plants until ran-off. After staying in a greenhouse at 15 ℃ and 80 ％relative atmospheric humidity for 15 days, severity of the plants were examined.

Table C:

Field Test 4 –Rice

Young rice plants were sprayed with a conidial suspension of Magnaporthe oryzae (anamorph: Pyricularia oryzae) , and incubated at 20 ℃ and 100 ％relative atmospheric humidity for 48 hours. The Formulations Examples were diluted 1000 times and then sprayed on the plants. After staying in a greenhouse at 15 ℃ and 80 ％relative atmospheric humidity for 15 days, severity of the plants were examined.

Table D:

All publications, patents and patent applications cited in this specification are herein incorporated by reference as if each individual publication or patent application were specifically and individually indicated to be incorporated by reference. Although the foregoing invention has been described in some detail by way of illustration and example for purposes of clarity of understanding, it will be readily apparent to those of ordinary skill in the art in light of the teachings of this invention that certain changes and modifications may be made thereto without departing from the spirit or scope of the appended claims.

Claims

A fungicidal composition comprising components:

(A) at least one strobilurin fungicides； and

(B) at least one triazole fungicides.
The fungicidal composition according to claim 1, wherein the strobilurin fungicide is selected from the group consisting of azoxystrobin, picoxystrobin, pyraclostrobin and combinations thereof.
The fungicidal composition according to claim 1, wherein the triazole fungicide is selected from the group consisting of cyproconazole, flutriafol or tebuconazole and combinations thereof.
The fungicidal composition according to any of the preceding claims, wherein a weight ratio of the component (A) to the component (B) is from 10:1 to 1:10, 5:1 to 1:5 or 2:1 to 1:2.
The fungicidal composition according to claim 1, wherein a total amount of the component (A) and the component (B) is from 2％to 95％by weight of the composition, preferably from 10％to 60％by weight of the composition more preferably from 20％to 40％by weight of the composition.
The fungicidal composition according to claim 1, wherein the component (A) is present in an amount of between from 1％to 75％by weight of the composition, preferably from 1％to 50％by weight of the composition, more preferably from 3％to 20％.
The fungicidal composition according to claim 1, wherein the component (B) is present in an amount of between from 1％to 70％by weight of the composition, preferably from 2％to 50％by weight of the composition, more preferably from 10％to 25％by weight of the composition.
The fungicidal composition according to claim 1, wherein the fungicidal composition can be diluted with water having the concentration 50-150 mL of the fungicidal composition in 100 L of water.
The fungicidal composition according to claim 1, the fungicidal composition is in a form of emulsifiable concentrates (EC) , emulsions (EW) , suspension concentrates (SC) , oil-based suspension concentrates (OD) , water-dispersible granules (WG) , water-dispersible powders (WP) , fine granule (FG) , suspoemulsions (SE) , microencapsulated suspensions (CS) , more preferably suspension concentrates (SC) .
The fungicidal composition according to claim 1, wherein the components (A) and (B) of the composition are:

(A) azoxystrobin, (B) cyproconazole；

(A) azoxystrobin, (B) flutriafol； or

(A) azoxystrobin, (B) tebuconazole.
The fungicidal composition according to claim 1, the fungicidal composition is applied to plants, plant parts and/or surrounding.
The fungicidal composition according to claim 11, the plants are selected from a group of cereals, fruits and vegetables.
The fungicidal composition according to claim 11, the plants are selected from a group of apple, grape, tomato and rice.
The fungicidal composition according to claim 1, the fungicidal composition is used for treating and/or preventing fungal diseases powdery mildew, apple scab and rice blast.
The fungicidal composition according to claim 1, the fungicidal composition is used for treating and/or preventing fungal diseases caused by Uncinula necator, Venturia inaequalis, Leveillula taurica and Magnaporthe oryzae (anamorph: Pyricularia oryzae) .
A method to prevent and/or treat fungal infestations in plants and plant parts by applying the fungicidal composition of the preceding claims.
A fungicidal composition comprising components (A) azoxystrobin and (B) tebuconazole； wherein the weight ratio of the components (A) and (B) in the composition is 1:2； and wherein the fungicidal composition is used for preventing and/or treating Uncinula necator of grape and its plant parts.