WO2015124943A1 - Cleaning composition - Google Patents

Cleaning composition Download PDF

Info

Publication number
WO2015124943A1
WO2015124943A1 PCT/GB2015/050498 GB2015050498W WO2015124943A1 WO 2015124943 A1 WO2015124943 A1 WO 2015124943A1 GB 2015050498 W GB2015050498 W GB 2015050498W WO 2015124943 A1 WO2015124943 A1 WO 2015124943A1
Authority
WO
WIPO (PCT)
Prior art keywords
composition
cleaning
alcohol
oil
antimicrobial agent
Prior art date
Application number
PCT/GB2015/050498
Other languages
French (fr)
Inventor
Sheika Fatima AL THANI
Original Assignee
HART, Deborah Mary
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by HART, Deborah Mary filed Critical HART, Deborah Mary
Publication of WO2015124943A1 publication Critical patent/WO2015124943A1/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/18Liquid substances or solutions comprising solids or dissolved gases
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/08Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/08Magnoliopsida [dicotyledons]
    • A01N65/28Myrtaceae [Myrtle family], e.g. teatree or clove
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/22Phase substances, e.g. smokes, aerosols or sprayed or atomised substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005Antimicrobial preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/10Washing or bathing preparations
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/20Organic compounds containing oxygen
    • C11D3/2003Alcohols; Phenols
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/20Organic compounds containing oxygen
    • C11D3/2003Alcohols; Phenols
    • C11D3/2006Monohydric alcohols
    • C11D3/201Monohydric alcohols linear
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/38Products with no well-defined composition, e.g. natural products
    • C11D3/382Vegetable products, e.g. soya meal, wood flour, sawdust
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/48Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D7/00Compositions of detergents based essentially on non-surface-active compounds
    • C11D7/22Organic compounds
    • C11D7/26Organic compounds containing oxygen
    • C11D7/261Alcohols; Phenols
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D7/00Compositions of detergents based essentially on non-surface-active compounds
    • C11D7/22Organic compounds
    • C11D7/40Products in which the composition is not well defined
    • C11D7/44Vegetable products
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/40Liliopsida [monocotyledons]
    • A01N65/42Aloeaceae [Aloe family] or Liliaceae [Lily family], e.g. aloe, veratrum, onion, garlic or chives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/20Targets to be treated
    • A61L2202/26Textiles, e.g. towels, beds, cloths

Definitions

  • the invention relates to a cleaning composition, in particular a sanitising composition.
  • the composition disclosed can be used to sanitise body cleaning articles.
  • the compositions of the invention can be used to sanitise surfaces.
  • the invention provides a cleaning composition comprising an antimicrobial agent dissolved in a mixture of an alcohol and an aqueous medium.
  • the composition preferably comprises 2- 75wt% alcohol, 0.5-5wt% antimicrobial agent and 24-97wt% aqueous media.
  • a "cleaning" composition is one that removes dirt from the article being cleaned.
  • the composition is a sanitising composition.
  • siaitise or “sanitising” means to reduce the number of microorganisms and optionally to remove dirt.
  • the composition of the invention comprises an antimicrobial agent, preferably a natural antimicrobial agent.
  • an "antimicrobial” agent is one that reduces the number of living microorganisms present. Such microorganisms are any one or more of bacteria, fungi, algae and viruses.
  • the composition comprises an effective amount of the antimicrobial agent, i.e.
  • the antimicrobial agent may be present at a concentration of 0.5-25wt%, preferably l-10wt%, more preferably 2-5wt% of the total composition.
  • the antimicrobial agent may be present at a concentration of 250 - 20,000 ppm, 500- 10,000ppm; 625- 5,000ppm; 1,250 -2,500ppm.
  • the antimicrobial agent may be present at a concentration of at least 250ppm, 500ppm, 650ppm, 1250ppm, 2500ppm, 5000ppm or
  • Preferred antimicrobial agents include plant derived essential oils. Such oils are well known to the person skilled in the art and include, for example, tea tree oil, rose geranium oil and Fragonia oil. Tea tree oil, or melaleuca oil, is obtained from the leaves of the Melaleuca alternifolia. It is known to be an effective topical antimicrobial agent active against a wide range of
  • Tea tree oil may have a clinical application in both the hospital and community, especially for clearance of methicillin-resistant Staphylococcus aureus (M SA) carriage or as a hand disinfectant to prevent cross-infection with Gram- positive and Gram-negative epidemic organisms.
  • M SA methicillin-resistant Staphylococcus aureus
  • MRSA glycopeptide-resistant enterococci
  • aminoglycoside-resistant Klebsiellae aminoglycoside-resistant Klebsiellae
  • Pseudomonas aeruginosa Pseudomonas aeruginosa
  • Stenotrophomonas maltophilia also against sensitive microorganisms.
  • the study was performed with two chemically different tea tree oils. One was a standard oil and the other was Clone 88 extracted from a specially bred tree, which has been selected and bred for increased activity and decreased skin irritation. The results confirm that the cloned oil had increased antimicrobial activity when compared with the standard oil. Most results indicated that the susceptibility pattern and Gram reaction of the organism did not influence the kill rate.
  • tea tree oil is derived from a Clone 88 Tree.
  • Rose geranium essential oil is extracted from the plant Pelargonium graveolens. Rose
  • geranium oil is a known antiseptic, and has a number of other beneficial properties such as antidepressant, astringent, promoting wound healing, diuretic, and deodorant.
  • Fragonia oil is obtained by steam distillation from the lignotubureous shrub, Agonis
  • Fragrans it has been found to have a number of beneficial properties. It acts as an antiinflammatory agent, a decongestant agent by breaking up mucus, soothes the irritation and nervous cough reactions linked to the lungs, an analgesic when used externally, an
  • the composition comprises Tea Tree oil and Fragonia oil. It has been surprisingly found that Tea Tree oil and Fragonia oil have a synergistic antimicrobial effect when used together.
  • the Tea Tree oil and Fragonia oil may each be present at a concentration of 250 - 20,000 ppm, 500-10,000ppm; 625- 5,000ppm; 1,250 -2,500ppm.
  • the Tea Tree oil and Fragonia oil may each be present at a concentration of at least 250ppm, 500ppm, 650ppm, 1250ppm, 2500ppm, 5000ppm or 10,000ppm.
  • the composition comprises at least 1250ppm Tea Tree oil and at least 1250ppm Fragonia oil.
  • the composition comprises an alcohol.
  • Preferred alcohols include ethanol, denatured alcohol or isopropanol. According to the Centers for Disease Control and Prevention, ethanol-based hand antiseptics containing 60 to 90 percent ethanol appear to be most effective against common pathogens. Ethanol-based sanitizers also seem to have greater antimicrobial effects against viruses than isopropanol-based sanitizers.
  • the composition may comprise l-75wt% alcohol, preferably 10-70wt% alcohol, more preferably 20-60wt%, 25-50wt% or 30-40wt% alcohol. The composition may comprise less than 40wt%, 30wt%, 20wt%, 15wt% or 10wt% alcohol.
  • the composition may contain more alcohol than aqueous media, in which case it is designated an alcohol-based composition.
  • An alcohol-based composition comprises about 55-70wt% alcohol, preferably about 60-67wt%, more preferably about 62-65wt% of the total composition.
  • Preferably the composition comprises about 66wt% alcohol.
  • the composition may contain more aqueous media than alcohol, in which case it is designated a water-based composition.
  • Water-based compositions comprise about 55-80wt% aqueous media, preferably about 60-75wt%, more preferably about 62-70wt% of the total composition. Preferably about 75wt% of the total water-based compositions is aqueous media.
  • aqueous media is defined as water or one or more plant extracts mixed with water.
  • the water used in the compositions is preferably deionized water. Suitable plant extracts are well known to the skilled person.
  • the plant extract water may be derived in a number of ways including: using undiluted extract from the plant mixed with water; dilution of a concentrated plant extract in water; and mixing a dried extract, for example a freeze dried extract, with water.
  • the concentration of extract used is the equivalent of at least 5g/L dried extract, for example 5-20 g/L, preferably 10-15g/L.
  • the aqueous media is aloe vera water produced by mixing aloe vera extract with water.
  • the aloe vera extract used can be derived from any part of the plant, preferably from the inner leaves of the plants, using methods known to the skilled person.
  • the composition may comprise 2-97wt% aqueous media.
  • the composition may comprise 10-95wt%, 20-90wt%, 25-85wt%, 30-80wt%, 35-75wt%, 40-70wt%, 45-65wt% or 50-55wt% aqueous media.
  • the composition comprises 24- 97wt% aqueous media.
  • the composition of the invention comprises natural ingredients. "Natural" as used herein means that the ingredient is produced within a living organism.
  • Preferably all of the active ingredients in the composition are natural. Even more preferably all of the ingredients in the composition are natural.
  • Preferred natural ingredients are derived from plants.
  • the compositions of the invention can also be formulated using non-plant derived or synthetic ingredients, including synthetic analogues of the natural ingredients.
  • the composition of the invention can be used to sanitise body cleaning articles.
  • Body Cleaning articles are used to apply soap or other cleansing products such as body wash or shower gel to the body including the face whilst washing for example in the bath or shower. Alternatively, or in addition, these articles are used to exfoliate the skin on the body. Examples of these articles include flannels, body mitts, loofahs, body brushes, sponges, shower puffs or scrubs.
  • Body cleaning article may be natural, such as sponges or loofahs, or may be synthetic, such a body mitts and shower puffs.
  • the composition of the invention can be left to air dry on the cleaning article or surface. It does not need to be washed off. A sanitising layer is left on the article or surface.
  • Body cleaning articles may be used on the skin of people of all ages, including children, after application of the composition. In addition the surfaces cleaned by the composition may be touched. Therefore the composition should be gentle on the skin of users, and not cause adverse reactions such as
  • composition may further comprise one or more additives, which are preferably natural. Suitable additives include, for example, perfumes, colouring agents and essential oils.
  • Colouring agents may be natural dyes or a synthetic dye, for example a polymeric colouring agent.
  • Polymeric colouring agents such as Liquitint ® , are non-staining, and more stable than natural dyes. They generally do not fade. In addition, as they are not absorbed by the skin they are are considered safer than normal food grade dyes. The dye is used in an amount necessary to obtain the desired depth of colour.
  • Essential oils can be added to impart fragrance and/or enhance sanitising properties.
  • Examples of essential oils which enhance sanitisation are lavender oil, lemon, neroli, peppermint or ylang ylang.
  • Other essential oils can be included for fragrance only.
  • the preferred concentration of essential oils in the composition is about 0.01 to 0.5g/L, preferably 0.1 to 0.25g/L.
  • composition may further comprise one or more excipients, which are preferably natural.
  • excipients are well known to the skilled person include, as examples, emollients, surfactants, stabilisers, foaming agents, preservatives and humectants.
  • Emollients soften the skin and can soothe irritated skin.
  • suitable emollients include vegetable, seed and nut oils, aloe vera extract, and glycerol.
  • Emollients may be present in an amount of about 0.5-20wt%, more preferably about 1- 10 wt%, most preferably about 3-8wt% of the total composition.
  • Surfactants are compounds that lower the surface tension between two liquids. In the composition of the invention they can be used to help solubilise the antimicrobial agents. In addition they can act as detergents, foaming agents and dispersants.
  • the surfactants may be ionic surfactants (cationic surfactants, such as amine or quaternary ammonium surfactants, or anionic surfactants, such as sulfate, sulfonate, phosphate ester or carboxylate surfactants), non-ionic surfactants (such as fatty acid surfactants), or zwitterionic
  • amphoteric surfactants such as phospholipids, phosphatidylserines,
  • the surfactants are non-ionic surfactants.
  • Preferred surfactants include alkyl polyglucosides, and fatty acid ethoxylates such as sorbitan monooleate and sorbitan trioleate.
  • the surfactants may be present in an amount of about l-25wt%, preferably, about 7-20wt%, more preferably about 10-15wt% of the total composition.
  • Humectants are usually hygroscopic chemicals which help to keep the skin moist and increase the skin penetration of other ingredients. Suitable humectants include sugar polyols and sugar alcohols such as sorbitol, malitol, and glycerol. Humectants may be present in an amount of about 0.5-20wt%, more preferably about 1- 10 wt% most preferably about 3- 8wt% of the total composition.
  • Stabilisers maintain the function and activity of other ingredients such as, for example, antimicrobial agents, fragrances and essential oils.
  • Suitable stabilisers include coconut oil derivatives.
  • Stabilisers may be present in an amount of about 0.5-20wt%, more preferably about 1- 10 wt% most preferably about 3-8wt% of the total composition.
  • Preservatives are used to prevent contamination by the growth of microorganisms, and/or undesirable chemical changes. They help to maintain the contents of the composition over the shelf life of the product. Suitable preservatives are known to the skilled person. One suitable preservative is Acticide MBS. Preservatives are used in an amount necessary to provide the desired effect i.e. to maintain the composition during storage over a number of years e.g. 1-5 years. Preservatives may be present in an amount of about 0.01-20wt%, about 0.1- 10 wt%, about 0.5-8wt% or about 1.0-5.0 wt% of the total composition. The composition may also include other ingredients which can be beneficial to the health of users of the composition, or the surface or cleaning article sanitized by the composition.
  • ingredients may help to maintain healthy skin by for example promoting cell proliferation and wound healing, increase skin smoothness, increase the moisture contact of the extracellular matrix.
  • these ingredients are natural.
  • suitable ingredients include allantoin and aloe vera extract.
  • Allantoin is present in botanical extracts of the comfrey plant and urine from most
  • allantoin is used as an active ingredient in over-the-counter cosmetics.
  • the claimed beneficial effects of allantoin include increased moisture content of the extracellular matrix, enhanced desquamation of upper layers of dead skin cells, increased skin smoothness, promotion of cell proliferation and wound healing, soothing, anti-irritant and skin protectant effect by forming complexes with irritant and sensitizing agents
  • Aloe vera called kathalai in Ayurvedic medicine, is used as a multipurpose skin treatment. This may be partly due to the presence of saponin, a chemical compound that acts as an antimicrobial agent.
  • the aloe vera extract is derived from the inner leaves of the aloe Vera plant.
  • Aloe vera water can be prepared by dissolving lOg spray dried aloe vera extract in about 2L deionised water.
  • antimicrobial agents may have other beneficial properties.
  • compositions to provide a calming effect may comprise
  • compositions comprising tea tree oil and optionally rose geranium may promote skin healing.
  • One preferred composition comprises Fragonia, aloe vera extract and allantoin.
  • Another preferred composition comprises Tea Tree oil, allantoin, aloe vera extract and optionally Rose Germanium oil.
  • the composition comprises 2-75wt% alcohol, 0.5-5wt% antimicrobial agent and 24-97wt% aqueous media.
  • the composition may comprise:
  • the antimicrobial agent may comprise Tea Tree oil and Fragonia oil, wherein the final composition comprises at least 0.5wt% of each component.
  • the composition comprises:
  • the composition may comprise about 55-70wt% alcohol and about 0.5-5wt% antimicrobial agent, with the balance made up to 100% with water or other aqueous media.
  • the antimicrobial agent may comprise Tea Tree oil and Fragonia oil, wherein the final composition comprises at least 0.25wt% of both. In some embodiments of the invention, the Tea Tree oil and Fragonia oil are present in equal quantities.
  • the composition may comprise 55-70wt% alcohol, 30-40 wt% aqueous media, and 0.5-5wt% antimicrobial agent.
  • the composition comprises:
  • compositions are wt% i.e. percentage by weight of the total composition.
  • the composition will generally comprise an alcohol and the antimicrobial agent (optionally additional components, such as surfactants, essentials oils, emollient and/or stabilisers, as described above), with the balance of the composition made up of aqueous media, such as aloe vera extract in water, to complete the composition up to 100wt%.
  • aqueous media such as aloe vera extract in water
  • the water may be deionised water.
  • the antimicrobial agent in the composition comprises Tea Tree oil and Fragonia oil, for example at least 0.25wt%, at least 0.5wt% or at least lwt% of each of Tea Tree oil and Fragonia oil by weight of the final composition.
  • the composition of the invention is preferably a liquid, preferably a sprayable liquid.
  • the composition may also be in the form of a gel or foam.
  • the composition may form a spray or foam when dispensed for use.
  • the composition may be dispensed from a pressurised container, such an aerosol can (and hence the container may further comprise a propellant), or from a container using a hand operated pump.
  • compositions of the invention can be used to clean and/or sanitise body cleaning articles by bringing the composition into contact with the cleaning article.
  • the composition may be sprayed onto the article and allowed to dry.
  • the cleaning article may be squeezed or rubbed to increase penetration of the composition into the article.
  • the cleaning article can be immersed, wholly or partially, or soaked in the composition of the invention.
  • the cleaning article is immersed for length of time, for example from 2-60 minutes, preferably 5-30 minutes, more preferably 10-15 minutes.
  • the cleaning article can then be removed, optionally squeezed to remove excess composition and allowed to air dry.
  • composition can be used after each use of the cleaning article.
  • composition can be used daily, twice weekly, weekly, fortnightly, monthly or at any other time period.
  • the invention also provides the use of the composition as a cleaning and/or sanitising composition.
  • the composition can be used to clean or sanitise a body cleaning article.
  • Preferred features of the composition are as described above.
  • the invention also provides a method of cleaning or sanitising a body cleaning article, comprising contacting said body cleaning article with a composition, said composition comprising an antimicrobial agent dissolved in a mixture of an alcohol and an aqueous media.
  • a composition comprising an antimicrobial agent dissolved in a mixture of an alcohol and an aqueous media.
  • Preferred features of the composition are as described above.
  • the step of contacting the article with the composition may comprise spraying the composition onto the article, or soaking and/or immersing the article in the composition.
  • the article may be completely or partially immersed in the composition.
  • the article is completely or partially immersed in a dilution of the composition, for example ap to a 1:1, 1:2, 1:3, 1:4, 1:5, 1:10 or 1:20 composition:water dilution.
  • a container such as a bottle or spray can, comprising a cleaning composition of the invention.
  • the container may be any suitable size, for example a 100ml, 250ml, 500ml or 1000ml container.
  • the container may therefore comprise 100ml, 250ml, 500ml or 1000ml of the cleaning composition of the invention.
  • the invention provides a kit comprising (i) a container comprising a cleaning composition as described herein and (ii) a body cleaning article. Preferred features of the composition are as described above.
  • the kit may further include instructions for use of the composition described herein.
  • compositions can be used to sanitise surfaces. Suitable surfaces are preferably non-porous surfaces in domestic or industrial settings. Examples of suitable surfaces include food preparation areas such as kitchen work surfaces and hobs; tiles; floors; and sanitary ware, such a basins, showers, and toilets.
  • the composition is an alcohol-based composition. The alcohol within the composition evaporates to leave a sanitising layer on the cleaned surface.
  • the composition can be sprayed onto the surface and then spread or wiped over the surface using a conventional cleaning cloth or tissue.
  • the composition may be supplied in a fabric impregnated or soaked in the composition, for example in the form of a wipe.
  • the invention also provides the use of a composition as described herein for cleaning and/or sanitising a surface.
  • a composition as described herein for cleaning and/or sanitising a surface.
  • Preferred features of the composition are as described above.
  • the composition is an alcohol-based composition.
  • the invention also provides a method of cleaning a hard surface comprising contacting said hard surface with a composition of the invention.
  • a composition of the invention Preferred features of the composition are as described above.
  • the composition is an alcohol-based composition.
  • the composition may be sprayed onto the surface and then distributed using a fabric cloth or tissue such as those conventionally used in domestic cleaning. Alternatively the composition can be applied to a conventional cleaning cloth or tissue, which is then wiped over the surface.
  • the surface may also be sanitised using a fabric cloth, such as a wet wipe, which is supplied impregnated with a composition of the invention.
  • a wipe such as a fabric wipe, impregnated with the composition of the invention.
  • the composition is an alcohol-based composition.
  • wipes are generally known as "wet-wipes". Materials and methods for producing such wipes are known in the art. Suitable materials for the wipe substrate include silk, keratin, cellulose (such as cotton), acetates, acrylics, polyesters, polyvinyl alcohols, nylon, polypropylene, polyethylene, polyurethane, polyvinyl chloride, rayon and mixtures thereof.
  • the wipes may be woven or non-woven.
  • wet wipes can be produced as air-laid paper where the fibres are carried and formed to the structure of paper by air.
  • wet wipes can be formed from synthetic fibres, or natural fibres such as cotton.
  • the fibres may be woven together.
  • the wipes are moistened or impregnated with the composition of the invention, preferably an alcohol-based composition.
  • the wipe may be treated with softeners or lotions as known by the skilled person.
  • the finished wet wipes can be folded and packaged singly or in multiple packs.
  • the wipes can be packaged in flexible plastic packs or in a box dispenser, as is conventional for wet wipes.
  • composition of the invention can be made by mixing all of the components together in a suitable vessel.
  • the ingredients can be added sequentially followed by thorough mixing before the next ingredient is added.
  • some components can be blended together, and then added to other ingredients, which also may be in the form a blend of two or more ingredients.
  • a composition for decontamination comprising alcohol and an antimicrobial agent in an aqueous medium, wherein the the antimicrobial agent comprises Tea Tree and Fragonia oil.
  • the alcohol can be present in an amount of 55-70wt%.
  • the antimicrobial agent can be present in an amount of about 0.5-5wt%, although the composition comprises at least 0.25% of each of the Tea Tree oil and Fragonia oil.
  • the Tea Tree oil and Fragonia oil are present in equal quantities. The balance of the composition to 100% is made up with the aqueous medium.
  • Example compositions of the invention Ethanol-based sanitisers
  • compositions listed above were prepared as follows:
  • Aloe Vera water is prepared by dissolving 5g Aloe Vera powder in 1L deionised water at least three hours before using the solution to allow the Aloe Vera to fully hydrate. Initially the powder is dissolved in approximately half the required quantity of water. Preservative is added and the solution made up to volume with deionised water.
  • Part B is made in a separate vessel.
  • Foam stabiliser/booster Hi Foam 750
  • MIC Minimum Inhibitory Concentration
  • Tea Tree oil and Fragonia oil samples were tested as received to determine MIC against selected strains of bacteria and fungi.
  • Mixed samples of Tea Tree oil and Fragonia oil (50/50 by weight) were tested to determine if there was any synergistic effect on M IC.
  • test sample Fraonia oil or Tea Tree Oil
  • 5g polysorbate 20 Diluted to lOOmL with deionised water.
  • the stock solution contains 20,000ppm essential oil.
  • a placebo (control) was prepared as described above omitting the essential oil.
  • the MIC is the concentration of the first well that has the same absorbance as the negative control well.
  • test viruses Herpes simplex
  • the surface is then treated with a solution containing a known concentration of essential oil.
  • the test solution is allowed to remain in contact with the test surface for approximately 15 minutes.
  • the surface is assayed for surviving viruses by an assay method specific for the test virus.
  • Test solutions were prepared as described for M IC against microorganisms.
  • test surface is inoculated with a solution containing a known concentration of Herpes simplex virus.
  • test surface is sprayed with the test solution until saturated. Excess liquid is allowed to drain and the surface left undisturbed for 1 hour.
  • the number of viable particles was determined using a culture test method specific to the virus.

Abstract

The invention relates to a cleaning composition, in particular a sanitising composition. The composition disclosed can be used to sanitise body cleaning articles. In addition the compositions of the invention can be used to sanitise surfaces.

Description

CLEANING COMPOSITION
The invention relates to a cleaning composition, in particular a sanitising composition. The composition disclosed can be used to sanitise body cleaning articles. In addition the compositions of the invention can be used to sanitise surfaces.
There is a general desire to keep the environments where we live clean and free from microorganisms, in particular those which may be harmful to our health. The cleaning products generally used contain chemicals which are harmful or cause irritation when touched with bare skin. There is a need for compositions which can remove microorganisms, but which are not harmful to human skin.
Surfaces, such as kitchen worktops, hobs, and sanitary ware, are exposed to microorganisms, in particular those which can cause sickness in people. The presence of microorganisms on these surfaces represents a risk to health, especially vulnerable people such as the elderly, children and immunocompromised patients. There is a need to provide cleaning compositions which can effectively clean these surfaces by removing dirt and grease, and leave a sanitising layer on the surface. Body cleaning articles are frequently used to cleanse and exfoliate the skin for example during a shower or bath. After use the materials are squeezed dry and/or simply allowed to air dry. A large amount of moisture is retained in the articles after use. In addition they are often kept in bathrooms which have a humid environment. This allows microorganisms removed from the skin and present in the environment to grow and multiply on the articles. In addition, over time the articles can become dirty or discoloured during use. Whilst some articles can be washed, others are often discarded as they cannot be easily cleaned, or become damaged during the cleaning process. There is a need to provide compositions that can be used to clean and/or sanitize body cleaning articles. The invention provides a cleaning composition comprising an antimicrobial agent dissolved in a mixture of an alcohol and an aqueous medium. The composition preferably comprises 2- 75wt% alcohol, 0.5-5wt% antimicrobial agent and 24-97wt% aqueous media. A "cleaning" composition is one that removes dirt from the article being cleaned. Preferably the composition is a sanitising composition. As used herein "sanitise" or "sanitising" means to reduce the number of microorganisms and optionally to remove dirt. The composition of the invention comprises an antimicrobial agent, preferably a natural antimicrobial agent. As used herein an "antimicrobial" agent is one that reduces the number of living microorganisms present. Such microorganisms are any one or more of bacteria, fungi, algae and viruses. The composition comprises an effective amount of the antimicrobial agent, i.e. at a concentration high enough to reduce the number of microorganisms present by 50wt%, 60wt%, 70wt%, 75wt%, 80wt%, 90wt%, 95wt%, or 99wt%. The antimicrobial agent may be present at a concentration of 0.5-25wt%, preferably l-10wt%, more preferably 2-5wt% of the total composition. The antimicrobial agent may be present at a concentration of 250 - 20,000 ppm, 500- 10,000ppm; 625- 5,000ppm; 1,250 -2,500ppm. The antimicrobial agent may be present at a concentration of at least 250ppm, 500ppm, 650ppm, 1250ppm, 2500ppm, 5000ppm or
10,000ppm.
Preferred antimicrobial agents include plant derived essential oils. Such oils are well known to the person skilled in the art and include, for example, tea tree oil, rose geranium oil and Fragonia oil. Tea tree oil, or melaleuca oil, is obtained from the leaves of the Melaleuca alternifolia. It is known to be an effective topical antimicrobial agent active against a wide range of
organisms. It has been reported that Tea tree oil may have a clinical application in both the hospital and community, especially for clearance of methicillin-resistant Staphylococcus aureus (M SA) carriage or as a hand disinfectant to prevent cross-infection with Gram- positive and Gram-negative epidemic organisms. The study, based on the time-kill approach, determined the kill rate of tea tree oil against several multidrug-resistant organisms,
including MRSA, glycopeptide-resistant enterococci, aminoglycoside-resistant Klebsiellae, Pseudomonas aeruginosa and Stenotrophomonas maltophilia, and also against sensitive microorganisms. The study was performed with two chemically different tea tree oils. One was a standard oil and the other was Clone 88 extracted from a specially bred tree, which has been selected and bred for increased activity and decreased skin irritation. The results confirm that the cloned oil had increased antimicrobial activity when compared with the standard oil. Most results indicated that the susceptibility pattern and Gram reaction of the organism did not influence the kill rate. A rapid killing time (less than 60 min) was achieved with both tea tree oils with most isolates, but MRSA was killed more slowly than other organisms. Preferably the tea tree oil is derived from a Clone 88 Tree. Rose geranium essential oil is extracted from the plant Pelargonium graveolens. Rose
geranium oil is a known antiseptic, and has a number of other beneficial properties such as antidepressant, astringent, promoting wound healing, diuretic, and deodorant.
Fragonia oil is obtained by steam distillation from the lignotubureous shrub, Agonis
Fragrans. it has been found to have a number of beneficial properties. It acts as an antiinflammatory agent, a decongestant agent by breaking up mucus, soothes the irritation and nervous cough reactions linked to the lungs, an analgesic when used externally, an
antimicrobial, and in regulating hormonal imbalances during the female menstrual cycle. It also helps to fights most common respiratory infections from the nose through to the lungs and is thought to strengthen and balance the immune system. Studies at the University of Western Australia have shown Fragonia to have significant anti-microbial activity, similar to that of other recognised anti-microbial essential oils. It has also been reported that Fragonia has the ability to balance, regulate, calm and help people let go of negative patterns of behaviour. It helps induce a deep and holistic healing process. It is also thought to be
valuable in dealing with unresolved core issues and transforming troubled family
relationships. In a preferred embodiment the composition comprises Tea Tree oil and Fragonia oil. It has been surprisingly found that Tea Tree oil and Fragonia oil have a synergistic antimicrobial effect when used together. The Tea Tree oil and Fragonia oil may each be present at a concentration of 250 - 20,000 ppm, 500-10,000ppm; 625- 5,000ppm; 1,250 -2,500ppm. The Tea Tree oil and Fragonia oil may each be present at a concentration of at least 250ppm, 500ppm, 650ppm, 1250ppm, 2500ppm, 5000ppm or 10,000ppm. Preferably the composition comprises at least 1250ppm Tea Tree oil and at least 1250ppm Fragonia oil.
The composition comprises an alcohol. Preferred alcohols include ethanol, denatured alcohol or isopropanol. According to the Centers for Disease Control and Prevention, ethanol-based hand antiseptics containing 60 to 90 percent ethanol appear to be most effective against common pathogens. Ethanol-based sanitizers also seem to have greater antimicrobial effects against viruses than isopropanol-based sanitizers. The composition may comprise l-75wt% alcohol, preferably 10-70wt% alcohol, more preferably 20-60wt%, 25-50wt% or 30-40wt% alcohol. The composition may comprise less than 40wt%, 30wt%, 20wt%, 15wt% or 10wt% alcohol. The composition may contain more alcohol than aqueous media, in which case it is designated an alcohol-based composition. An alcohol-based composition comprises about 55-70wt% alcohol, preferably about 60-67wt%, more preferably about 62-65wt% of the total composition. Preferably the composition comprises about 66wt% alcohol.
The composition may contain more aqueous media than alcohol, in which case it is designated a water-based composition. Water-based compositions comprise about 55-80wt% aqueous media, preferably about 60-75wt%, more preferably about 62-70wt% of the total composition. Preferably about 75wt% of the total water-based compositions is aqueous media.
As used herein "aqueous media" is defined as water or one or more plant extracts mixed with water. The water used in the compositions is preferably deionized water. Suitable plant extracts are well known to the skilled person. The plant extract water may be derived in a number of ways including: using undiluted extract from the plant mixed with water; dilution of a concentrated plant extract in water; and mixing a dried extract, for example a freeze dried extract, with water. Preferably the concentration of extract used is the equivalent of at least 5g/L dried extract, for example 5-20 g/L, preferably 10-15g/L. In a preferred embodiment the aqueous media is aloe vera water produced by mixing aloe vera extract with water. The aloe vera extract used can be derived from any part of the plant, preferably from the inner leaves of the plants, using methods known to the skilled person. The composition may comprise 2-97wt% aqueous media. The composition may comprise 10-95wt%, 20-90wt%, 25-85wt%, 30-80wt%, 35-75wt%, 40-70wt%, 45-65wt% or 50-55wt% aqueous media. In one embodiment the composition comprises 24- 97wt% aqueous media. Preferably the composition of the invention comprises natural ingredients. "Natural" as used herein means that the ingredient is produced within a living organism. Preferably all of the active ingredients in the composition are natural. Even more preferably all of the ingredients in the composition are natural. Preferred natural ingredients are derived from plants. However, the compositions of the invention can also be formulated using non-plant derived or synthetic ingredients, including synthetic analogues of the natural ingredients.
The composition of the invention can be used to sanitise body cleaning articles. Body Cleaning articles are used to apply soap or other cleansing products such as body wash or shower gel to the body including the face whilst washing for example in the bath or shower. Alternatively, or in addition, these articles are used to exfoliate the skin on the body. Examples of these articles include flannels, body mitts, loofahs, body brushes, sponges, shower puffs or scrubs. Body cleaning article may be natural, such as sponges or loofahs, or may be synthetic, such a body mitts and shower puffs. The composition of the invention can be left to air dry on the cleaning article or surface. It does not need to be washed off. A sanitising layer is left on the article or surface. Body cleaning articles may be used on the skin of people of all ages, including children, after application of the composition. In addition the surfaces cleaned by the composition may be touched. Therefore the composition should be gentle on the skin of users, and not cause adverse reactions such as irritation and dryness.
The presence of agents beneficial to the skin in the composition is preferred. In addition it is desirable for the composition to have a pleasant perfume. The composition can also be coloured so that it is visually attractive before and during use. Thus the composition may further comprise one or more additives, which are preferably natural. Suitable additives include, for example, perfumes, colouring agents and essential oils.
Colouring agents may be natural dyes or a synthetic dye, for example a polymeric colouring agent. Polymeric colouring agents, such as Liquitint®, are non-staining, and more stable than natural dyes. They generally do not fade. In addition, as they are not absorbed by the skin they are are considered safer than normal food grade dyes. The dye is used in an amount necessary to obtain the desired depth of colour.
Essential oils can be added to impart fragrance and/or enhance sanitising properties. Examples of essential oils which enhance sanitisation are lavender oil, lemon, neroli, peppermint or ylang ylang. Other essential oils can be included for fragrance only. The preferred concentration of essential oils in the composition is about 0.01 to 0.5g/L, preferably 0.1 to 0.25g/L.
The composition may further comprise one or more excipients, which are preferably natural. Suitable excipients are well known to the skilled person include, as examples, emollients, surfactants, stabilisers, foaming agents, preservatives and humectants.
Emollients soften the skin and can soothe irritated skin. Examples of suitable emollients include vegetable, seed and nut oils, aloe vera extract, and glycerol. Emollients may be present in an amount of about 0.5-20wt%, more preferably about 1- 10 wt%, most preferably about 3-8wt% of the total composition.
Surfactants are compounds that lower the surface tension between two liquids. In the composition of the invention they can be used to help solubilise the antimicrobial agents. In addition they can act as detergents, foaming agents and dispersants. The surfactants may be ionic surfactants (cationic surfactants, such as amine or quaternary ammonium surfactants, or anionic surfactants, such as sulfate, sulfonate, phosphate ester or carboxylate surfactants), non-ionic surfactants (such as fatty acid surfactants), or zwitterionic
(amphoteric) surfactants (such as phospholipids, phosphatidylserines,
phosphatidylethanolamines, phosphatidylcholines, and sphingomyelins). In some ebodiments, the surfactants are non-ionic surfactants. Preferred surfactants include alkyl polyglucosides, and fatty acid ethoxylates such as sorbitan monooleate and sorbitan trioleate. The surfactants may be present in an amount of about l-25wt%, preferably, about 7-20wt%, more preferably about 10-15wt% of the total composition.
Humectants are usually hygroscopic chemicals which help to keep the skin moist and increase the skin penetration of other ingredients. Suitable humectants include sugar polyols and sugar alcohols such as sorbitol, malitol, and glycerol. Humectants may be present in an amount of about 0.5-20wt%, more preferably about 1- 10 wt% most preferably about 3- 8wt% of the total composition.
Stabilisers maintain the function and activity of other ingredients such as, for example, antimicrobial agents, fragrances and essential oils. Suitable stabilisers include coconut oil derivatives. Stabilisers may be present in an amount of about 0.5-20wt%, more preferably about 1- 10 wt% most preferably about 3-8wt% of the total composition.
Preservatives are used to prevent contamination by the growth of microorganisms, and/or undesirable chemical changes. They help to maintain the contents of the composition over the shelf life of the product. Suitable preservatives are known to the skilled person. One suitable preservative is Acticide MBS. Preservatives are used in an amount necessary to provide the desired effect i.e. to maintain the composition during storage over a number of years e.g. 1-5 years. Preservatives may be present in an amount of about 0.01-20wt%, about 0.1- 10 wt%, about 0.5-8wt% or about 1.0-5.0 wt% of the total composition. The composition may also include other ingredients which can be beneficial to the health of users of the composition, or the surface or cleaning article sanitized by the composition.
These ingredients may help to maintain healthy skin by for example promoting cell proliferation and wound healing, increase skin smoothness, increase the moisture contact of the extracellular matrix. Preferably these ingredients are natural. Examples of suitable ingredients include allantoin and aloe vera extract.
Allantoin is present in botanical extracts of the comfrey plant and urine from most
mammals, notably cows. The most commonly used species of comfrey to obtain allantoin is Russian comfrey Symphytum xuplandicum which is a cross or hybrid of Symphytum officinale (Common Comfrey) and Symphytum asperum (Rough Comfrey). Allantoin is used as an active ingredient in over-the-counter cosmetics. The claimed beneficial effects of allantoin include increased moisture content of the extracellular matrix, enhanced desquamation of upper layers of dead skin cells, increased skin smoothness, promotion of cell proliferation and wound healing, soothing, anti-irritant and skin protectant effect by forming complexes with irritant and sensitizing agents
Aloe vera, called kathalai in Ayurvedic medicine, is used as a multipurpose skin treatment. This may be partly due to the presence of saponin, a chemical compound that acts as an antimicrobial agent. The aloe vera extract is derived from the inner leaves of the aloe Vera plant. Aloe vera water can be prepared by dissolving lOg spray dried aloe vera extract in about 2L deionised water.
As discussed above the antimicrobial agents may have other beneficial properties.
Additional ingredients can be selected to prepare compositions which provide specific desired effects. For example compositions to provide a calming effect may comprise
Fragonia, whilst compositions comprising tea tree oil and optionally rose geranium may promote skin healing. One preferred composition comprises Fragonia, aloe vera extract and allantoin. Another preferred composition comprises Tea Tree oil, allantoin, aloe vera extract and optionally Rose Germanium oil.
In one embodiment the composition comprises 2-75wt% alcohol, 0.5-5wt% antimicrobial agent and 24-97wt% aqueous media. The composition may comprise:
2-75wt% alcohol
l-5wt% antimicrobial agent 7-20wt% surfactant
l-10wt% emollient
l-10wt% stabiliser
0-0.05wt% essential oils
balance aqueous media
The antimicrobial agent may comprise Tea Tree oil and Fragonia oil, wherein the final composition comprises at least 0.5wt% of each component. In a preferred embodiment the composition comprises:
3wt% ethanol
0.1wt% allantoin
2wt% Glycerol
8wt% Polyoxyethylene (20) sorbitan monooleate
2wt% Tea tree oil
2wt% Fragonia oil
4.5 wt% polyglycoside surfactant based on a C8-C16 natural fatty alcohol 3 wt% Foam booster/stabiliser
balance aloe vera extract in water
In one embodiment, the composition may comprise about 55-70wt% alcohol and about 0.5-5wt% antimicrobial agent, with the balance made up to 100% with water or other aqueous media. The antimicrobial agent may comprise Tea Tree oil and Fragonia oil, wherein the final composition comprises at least 0.25wt% of both. In some embodiments of the invention, the Tea Tree oil and Fragonia oil are present in equal quantities.
In one embodiment, the composition may comprise 55-70wt% alcohol, 30-40 wt% aqueous media, and 0.5-5wt% antimicrobial agent. Preferably the composition comprises:
66.3wt% alcohol
0.6 wt% antimicrobial agent
0-0.05 wt% essential oils
balance aqueous media
All percentages of components for the compositions are wt% i.e. percentage by weight of the total composition. In embodiments of the invention, the composition will generally comprise an alcohol and the antimicrobial agent (optionally additional components, such as surfactants, essentials oils, emollient and/or stabilisers, as described above), with the balance of the composition made up of aqueous media, such as aloe vera extract in water, to complete the composition up to 100wt%. The water may be deionised water. In some embodiments of the invention, the antimicrobial agent in the composition comprises Tea Tree oil and Fragonia oil, for example at least 0.25wt%, at least 0.5wt% or at least lwt% of each of Tea Tree oil and Fragonia oil by weight of the final composition.
The composition of the invention is preferably a liquid, preferably a sprayable liquid. The composition may also be in the form of a gel or foam. The composition may form a spray or foam when dispensed for use. The composition may be dispensed from a pressurised container, such an aerosol can (and hence the container may further comprise a propellant), or from a container using a hand operated pump.
The compositions of the invention can be used to clean and/or sanitise body cleaning articles by bringing the composition into contact with the cleaning article. The composition may be sprayed onto the article and allowed to dry. Optionally the cleaning article may be squeezed or rubbed to increase penetration of the composition into the article. Alternatively the cleaning article can be immersed, wholly or partially, or soaked in the composition of the invention. The cleaning article is immersed for length of time, for example from 2-60 minutes, preferably 5-30 minutes, more preferably 10-15 minutes. The cleaning article can then be removed, optionally squeezed to remove excess composition and allowed to air dry.
The composition can be used after each use of the cleaning article. Alternatively the composition can be used daily, twice weekly, weekly, fortnightly, monthly or at any other time period.
The invention also provides the use of the composition as a cleaning and/or sanitising composition. Preferably the composition can be used to clean or sanitise a body cleaning article. Preferred features of the composition are as described above.
The invention also provides a method of cleaning or sanitising a body cleaning article, comprising contacting said body cleaning article with a composition, said composition comprising an antimicrobial agent dissolved in a mixture of an alcohol and an aqueous media. Preferred features of the composition are as described above. The step of contacting the article with the composition may comprise spraying the composition onto the article, or soaking and/or immersing the article in the composition. The article may be completely or partially immersed in the composition. In some embodiments, the article is completely or partially immersed in a dilution of the composition, for example ap to a 1:1, 1:2, 1:3, 1:4, 1:5, 1:10 or 1:20 composition:water dilution.
In another aspect of the invention there is provided a container, such as a bottle or spray can, comprising a cleaning composition of the invention. The container may be any suitable size, for example a 100ml, 250ml, 500ml or 1000ml container. The container may therefore comprise 100ml, 250ml, 500ml or 1000ml of the cleaning composition of the invention.
In a further aspect the invention provides a kit comprising (i) a container comprising a cleaning composition as described herein and (ii) a body cleaning article. Preferred features of the composition are as described above. The kit may further include instructions for use of the composition described herein.
Compositions can be used to sanitise surfaces. Suitable surfaces are preferably non-porous surfaces in domestic or industrial settings. Examples of suitable surfaces include food preparation areas such as kitchen work surfaces and hobs; tiles; floors; and sanitary ware, such a basins, showers, and toilets. Preferably the composition is an alcohol-based composition. The alcohol within the composition evaporates to leave a sanitising layer on the cleaned surface. The composition can be sprayed onto the surface and then spread or wiped over the surface using a conventional cleaning cloth or tissue. Alternatively the composition may be supplied in a fabric impregnated or soaked in the composition, for example in the form of a wipe.
The invention also provides the use of a composition as described herein for cleaning and/or sanitising a surface. Preferred features of the composition are as described above. Preferably the composition is an alcohol-based composition.
The invention also provides a method of cleaning a hard surface comprising contacting said hard surface with a composition of the invention. Preferred features of the composition are as described above. Preferably the composition is an alcohol-based composition. The composition may be sprayed onto the surface and then distributed using a fabric cloth or tissue such as those conventionally used in domestic cleaning. Alternatively the composition can be applied to a conventional cleaning cloth or tissue, which is then wiped over the surface. The surface may also be sanitised using a fabric cloth, such as a wet wipe, which is supplied impregnated with a composition of the invention.
Also provided is a wipe, such as a fabric wipe, impregnated with the composition of the invention. Preferred features of the composition are as described above. Preferably the composition is an alcohol-based composition. Such wipes are generally known as "wet-wipes". Materials and methods for producing such wipes are known in the art. Suitable materials for the wipe substrate include silk, keratin, cellulose (such as cotton), acetates, acrylics, polyesters, polyvinyl alcohols, nylon, polypropylene, polyethylene, polyurethane, polyvinyl chloride, rayon and mixtures thereof. The wipes may be woven or non-woven. Depending on the material used, typically wet wipes can be produced as air-laid paper where the fibres are carried and formed to the structure of paper by air. Alternatively wet wipes can be formed from synthetic fibres, or natural fibres such as cotton. The fibres may be woven together. The wipes are moistened or impregnated with the composition of the invention, preferably an alcohol-based composition. The wipe may be treated with softeners or lotions as known by the skilled person. The finished wet wipes can be folded and packaged singly or in multiple packs. The wipes can be packaged in flexible plastic packs or in a box dispenser, as is conventional for wet wipes.
The composition of the invention can be made by mixing all of the components together in a suitable vessel. The ingredients can be added sequentially followed by thorough mixing before the next ingredient is added. Alternatively some components can be blended together, and then added to other ingredients, which also may be in the form a blend of two or more ingredients.
In one embodiment of the invention there is provided a composition for decontamination, comprising alcohol and an antimicrobial agent in an aqueous medium, wherein the the antimicrobial agent comprises Tea Tree and Fragonia oil. The alcohol can be present in an amount of 55-70wt%. The antimicrobial agent can be present in an amount of about 0.5-5wt%, although the composition comprises at least 0.25% of each of the Tea Tree oil and Fragonia oil. Optionally, the Tea Tree oil and Fragonia oil are present in equal quantities. The balance of the composition to 100% is made up with the aqueous medium. Example compositions of the invention Ethanol-based sanitisers
Figure imgf000013_0001
Water-based compositions
Figure imgf000013_0002
The composition listed above was prepared as follows:
Part A
Aloe Vera water is prepared by dissolving 5g Aloe Vera powder in 1L deionised water at least three hours before using the solution to allow the Aloe Vera to fully hydrate. Initially the powder is dissolved in approximately half the required quantity of water. Preservative is added and the solution made up to volume with deionised water.
Part B
Part B is made in a separate vessel.
Allantoin and ethanol are mixed thoroughly until no powder remains.
Add glycerol and blend thoroughly.
Add Polyoxyethylene (20) sorbitan monooleate (Ecoteric T20) and blend thoroughly.
Add Fragonia and/or Tea Tree Oil and blend thoroughly.
Add any essential oil used for fragrance and blend thoroughly.
Part C
Add Aloe Vera water slowly to Part B. Initially, add dropwise stirring thoroughly.
When the volume of Aloe Vera water added is approximately equal to the initial volume of Part B, add polyglycoside surfactant based on a C8-C16 natural fatty alcohol (Glucopon 425 N) and stir thoroughly.
Add Foam stabiliser/booster (Hi Foam 750) and stir thoroughly.
Add Aloe Vera water until final volume is attained.
Add dye, if required, when volume is approximately 95wt% of the final volume.
Examples Minimum Inhibitory Concentration (MIC) of Tea Tree Oil, Fragonia Oil and Mixtures of Tea Tree Oil and Fragonia Oil against selected microorganisms
Overview
Tea Tree oil and Fragonia oil samples were tested as received to determine MIC against selected strains of bacteria and fungi. Mixed samples of Tea Tree oil and Fragonia oil (50/50 by weight) were tested to determine if there was any synergistic effect on M IC.
Samples
Approximately 5mL Tea Tree Oil and 5mL Fragonia oil were provided for testing. Preparation of Stock Solutions for Testing
Accurately weigh 2,000 ±10mg test sample (Fragonia oil or Tea Tree Oil) and mix thoroughly with 5g polysorbate 20. Diluted to lOOmL with deionised water. The stock solution contains 20,000ppm essential oil.
Preparation of Stock Solution of Mixed Essential Oils
Accurately pipette 20mL of the stock solution of Tea Tree oil and 20mL of Fragonia oil. Mix thoroughly. This solution contains l,000ppm of tea Tree oil and l,000ppm of Fragonia oil.
Preparation of Placebo Solution
A placebo (control) was prepared as described above omitting the essential oil.
Working Inoculum Preparation
Inoculate 2-3 bacterial colonies from an 18 hour plate culture into lOmL of Muller Hinton Broth (MHB). Vortex and incubate at 37±2°C for 6 hours. Adjust this to a 0.5 McFarland Standard with MHB. Check by measuring absorbance at 625nm and adjust to a final absorbance of 0.080-0.100. This is the working inoculum. Final bacterial suspension for testing requires a 1:500 dilution in MHB. Add O.lmL of working inoculum to 9.9mL of M HB. Then take 4 mL of this dilution and add to 16 mL of M HB to make the final inoculum (approx. 2 χ 105 CFU/mL). Final bacterial suspension should be used within 15 minutes of preparation. Determine the total viable count (TVC) of the final bacterial suspension.
96 Well Plate Preparation:
Perform this step in a biological safety cabinet.
Note this test is adapted from standard test procedures. In practice only six dilutions were carried out per sample i.e. samples were only tested at 20,000, 10,000, 5,000, 2,500, 1,250 and 625ppm.
1. Add 10 μί of stock solution to Column 12 (20,000 ppm). Add 10 μί of serially diluted solutions to Columns 11 to 3 respectively. Columns 1 and 2 are negative and positive control wells - add 10 μί of placebo to each.
2. Pour Muller Hinton Broth into a sterile trough
3. Adjust the pipette to 90μί and dispense M HB from the trough into wells columns 1-12. (1 and 2 are positive and negative control wells)
4. Add ΙΟΟμί of final bacterial suspension to columns 2-12 (column 1 is the negative control). 5. Seal the tray carefully with plastic adhesive lid. Label appropriately. Make sure bacteria/test solutions are mixed adequately by tapping 96 well plates sharply a couple of times.
6. Incubate at 37±2°C for 24 hours. Stack no more than 4 plates high. Reading the Plate:
Read the plate at 450nm using an ELISA reader.
Determine any dramatic changes in absorbance. The MIC is the concentration of the first well that has the same absorbance as the negative control well.
Results
Table 1 Activity against Microorganisms
Figure imgf000016_0001
Table 2 Activity against Fungi
Figure imgf000016_0002
Discussion of Results
Note that the method of dilution meant that samples were tested at 20,000, 10,000, 5,000, 2,500, 1,250 and 625ppm. Finer gradations of activity are not be differentiated by this method. Further work is required in the range 2,500 to >5,000ppm to determine MIC values with greater precision.
The results against E coli and S Aureus were similar for Tea Tree and Fragonia oil. The results for the mixed solution clearly indicated a synergistic effect with a mixture of essential oils.
The results against the fungus A. niger suggested that Fragonia oil has higher activity against this organism than Tea Tree oil. Results for C. albicans were similar for both essential oils. There was clearly a synergistic effect in the case of C. albicans. Antiviral Activity of Tea Tree Oil, Fragonia Oil and Mixtures of Tea Tree Oil and Fragonia Oil against human Herpes simplex virus
Overview A representative surface is inoculated with the test viruses (Herpes simplex). The surface is then treated with a solution containing a known concentration of essential oil. The test solution is allowed to remain in contact with the test surface for approximately 15 minutes. Following treatment, the surface is assayed for surviving viruses by an assay method specific for the test virus.
Preparation of Test Solutions
Test solutions were prepared as described for M IC against microorganisms.
Preparation of Test Surfaces
The test surface is inoculated with a solution containing a known concentration of Herpes simplex virus.
Test Method
The test surface is sprayed with the test solution until saturated. Excess liquid is allowed to drain and the surface left undisturbed for 1 hour.
Assay
The number of viable particles was determined using a culture test method specific to the virus.
Results
Table 3 Activity against Herpes Simplex
Figure imgf000017_0001
Conclusion
The results indicate that Tea Tree oil and Fragonia oil are similar with respect to antiviral activity. The results also suggest that there is a synergistic effect when the two essential oils are mixed.

Claims

Claims
1. A cleaning composition comprising an antimicrobial agent dissolved in a mixture of an alcohol and an aqueous media, wherein said antimicrobial agent comprises Tea Tree oil and Fragonia oil.
2. A cleaning composition of claim 1 wherein said composition comprises:
2-75 %wt alcohol;
0.5-5 %wt antimicrobial agent; and
24-97 %wt aqueous media.
3. A cleaning composition of claim 1 or claim 2 wherein said composition comprises 2-75%wt alcohol;
l-5%wt antimicrobial agent;
7-20%wt surfactant;
l-10 wt emollient;
l-10 wt stabiliser;
0-0.05%wt essential oils; and
balance percentage aqueous media.
4. A cleaning composition as claimed in any preceeding claim comprising
3%wt ethanol;
0.1%wt allantoin;
2%wt Glycerol;
8%wt Polyoxyethylene (20) sorbitan monoledate;
2%wt Tea tree oil;
2%wt Fragonia oil;
4.5%wt alkyl polyglycoside surfactant based on a natural C8-C16 fatty alcohol;
3%wt Foam stabiliser/booster; and
balance aloe vera extract in water.
5. A cleaning composition as claimed in claim 1 or claim 2 comprising
55-70%wt alcohol;
30-40 wt aqueous media; and
0.5-5%wt antimicrobial agent.
6. A cleaning composition as claimed in claim 1, 2, or 5 comprising
66.3%wt alcohol;
0.6 %wt antimicrobial agent;
0-0.05 wt essential oils; and balance aqueous media.
7. A cleaning composition as claimed in any preceding claim comprising at least 1250ppm Tea Tree oil and 1250ppm Fragonia oil.
8. A composition as claimed in any preceding claim wherein the antimicrobial agent is natural.
9. A composition as claimed in any preceding claim wherein the antimicrobial agent further comprises Rose geranium.
10. A composition as claimed in any preceding claim wherein said composition further comprising one or more excipients.
11. A composition as claimed in claim 10 wherein the excipient is selected from essential oils, colourants, perfumes, emollients, surfactants, stabilisers.
12. A composition as claimed in any preceding claim wherein said composition is a water- based composition.
13. A composition as claimed in any preceding claim wherein said composition is an alcohol- based composition.
14. A composition as claimed in any preceding claim wherein said alcohol is ethanol.
15. A method of cleaning a body cleaning article, comprising contacting said body cleaning article with a composition, said composition comprising an antimicrobial agent dissolved in a mixture of an alcohol and an aqueous media.
16. A method as claimed in claim 15 wherein said composition is a composition as claimed in any one of claims 1 to 14.
17. A method as claimed in claim 15 or claim 16, wherein contacting said body cleaning article comprises spraying the composition onto said body cleaning article.
18. A method as claimed in any one of claims 15 to 17, wherein contacting said body cleaning article comprises soaking or wholly or partially immersing the body cleaning article in the composition.
19. Use of a cleaning composition as claimed in any one of claims 1 to 14 in cleaning and/or sanitising a body cleaning article or a surface.
20. A kit comprising a body cleaning article and a container comprising a cleaning composition as claimed in any one of claims 1 to 14.
PCT/GB2015/050498 2014-02-20 2015-02-20 Cleaning composition WO2015124943A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1403017.5A GB2523340A (en) 2014-02-20 2014-02-20 Composition
GB1403017.5 2014-02-20

Publications (1)

Publication Number Publication Date
WO2015124943A1 true WO2015124943A1 (en) 2015-08-27

Family

ID=50482530

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2015/050498 WO2015124943A1 (en) 2014-02-20 2015-02-20 Cleaning composition

Country Status (2)

Country Link
GB (1) GB2523340A (en)
WO (1) WO2015124943A1 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105670844A (en) * 2016-03-15 2016-06-15 湖北工业大学 Disposable loofah sponge energy-saving soap and preparation method thereof
CN108719356A (en) * 2018-08-23 2018-11-02 张爱婷 A kind of mild medical treatment and nursing disinfectant and preparation method thereof
US10806769B2 (en) 2016-03-31 2020-10-20 Gojo Industries, Inc. Antimicrobial peptide stimulating cleansing composition
US10874700B2 (en) 2016-03-31 2020-12-29 Gojo Industries, Inc. Sanitizer composition with probiotic/prebiotic active ingredient
US11564879B2 (en) 2016-11-23 2023-01-31 Gojo Industries, Inc. Sanitizer composition with probiotic/prebiotic active ingredient

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998042386A1 (en) * 1997-03-24 1998-10-01 Mainstar One Investments Pty. Ltd. Preservative composition containing tea tree oil (tto)
WO2001041573A1 (en) * 1999-12-13 2001-06-14 Ethicon, Inc. Therapeutic antimicrobial compositions
US20100247376A1 (en) * 2009-03-31 2010-09-30 Trevor Douglas Yuros Antibacterial toothbrush spray
WO2013006917A1 (en) * 2011-07-14 2013-01-17 Sunnywipes Pty Ltd Disinfecting formulations and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4587123A (en) * 1984-06-28 1986-05-06 Price Jacqueline S Compositions and methods for reducing pest infestation
WO2007069214A2 (en) * 2005-12-15 2007-06-21 The Procter & Gamble Company Wet wipes with natural antimicrobial agents
DE102008029009A1 (en) * 2008-06-20 2009-12-24 Henkel Ag & Co. Kgaa Aqueous disinfectant, useful for the disinfection of hard surfaces and for skin disinfection, comprises ethanol and/or propanol and tea-tree oil
WO2011156415A2 (en) * 2010-06-07 2011-12-15 Intelligent Aromas, Llc Antimicrobial composition and method for using same
AU2011205082A1 (en) * 2010-07-29 2012-02-16 Environmental Technologies (Australia) Pty Ltd Sanitising antimicrobial compositions
US20130177504A1 (en) * 2011-06-17 2013-07-11 Annuary Healthcare, Inc. Nanoscale Particle Formulations and Methods

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998042386A1 (en) * 1997-03-24 1998-10-01 Mainstar One Investments Pty. Ltd. Preservative composition containing tea tree oil (tto)
WO2001041573A1 (en) * 1999-12-13 2001-06-14 Ethicon, Inc. Therapeutic antimicrobial compositions
US20100247376A1 (en) * 2009-03-31 2010-09-30 Trevor Douglas Yuros Antibacterial toothbrush spray
WO2013006917A1 (en) * 2011-07-14 2013-01-17 Sunnywipes Pty Ltd Disinfecting formulations and uses thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
"A New Australian Native Fragonia Essential Oil - Agonis fragrans", ESSENTIAL THERAPEUTICS, vol. 20, 31 January 2008 (2008-01-31), XP055184608 *
KATHERINE A. HAMMER ET AL: "Antimicrobial and anti-inflammatory activity of five Taxandria fragrans oils in vitro", MICROBIOLOGY AND IMMUNOLOGY, vol. 52, no. 11, 1 November 2008 (2008-11-01), pages 522 - 530, XP055184754, ISSN: 0385-5600, DOI: 10.1111/j.1348-0421.2008.00070.x *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105670844A (en) * 2016-03-15 2016-06-15 湖北工业大学 Disposable loofah sponge energy-saving soap and preparation method thereof
CN105670844B (en) * 2016-03-15 2018-09-25 湖北工业大学 Disposable luffa energy-saving soap and preparation method thereof
US10806769B2 (en) 2016-03-31 2020-10-20 Gojo Industries, Inc. Antimicrobial peptide stimulating cleansing composition
US10874700B2 (en) 2016-03-31 2020-12-29 Gojo Industries, Inc. Sanitizer composition with probiotic/prebiotic active ingredient
US11633451B2 (en) 2016-03-31 2023-04-25 Gojo Industries, Inc. Antimicrobial peptide stimulating cleansing composition
US11564879B2 (en) 2016-11-23 2023-01-31 Gojo Industries, Inc. Sanitizer composition with probiotic/prebiotic active ingredient
CN108719356A (en) * 2018-08-23 2018-11-02 张爱婷 A kind of mild medical treatment and nursing disinfectant and preparation method thereof

Also Published As

Publication number Publication date
GB201403017D0 (en) 2014-04-09
GB2523340A (en) 2015-08-26

Similar Documents

Publication Publication Date Title
CN104873432B (en) Handguard type Washing free gel for disinfection and preparation method thereof
CA2487270C (en) Antimicrobial compositions, products and methods employing same
US7569530B1 (en) Antimicrobial compositions, products and methods employing same
CN104116454B (en) A kind of wet tissue and preparation method thereof
US20040001797A1 (en) Antimicrobial compositions, products and methods employing same
US20090035339A1 (en) Methods of Inactivating Viruses
CN111449093A (en) Natural essential oil composition with antibacterial and disinfecting effects and application thereof
US8741271B2 (en) Antimicrobial compositions containing essential oils
US10456437B1 (en) Antibacterial wet wipe for skin care
WO2015124943A1 (en) Cleaning composition
JP2003113013A (en) Vegetable antimicrobial preservative
JP6987862B2 (en) Antibacterial composition containing trace-acting metals
US9693941B2 (en) Liquid personal wash composition
US20140030203A1 (en) Antimicrobial compositions containing essential oils
WO2005013688A2 (en) Anti-microbial composition
MX2014006836A (en) Antimicrobial composition.
WO2017202586A1 (en) Antimicrobial compositions for topical use
CN113423469A (en) Topical disinfectant compositions
CN115209731A (en) Cleaning composition
WO2020057285A1 (en) Atractylodes oil and/or cassia twig oil, production method therefor and use thereof
JPH07252105A (en) Liquid disinfectant
AU2021104043A4 (en) A Polyherbal Gel Composition For Preventing Ill Effect Of Sanitizers.
RU2744273C1 (en) Sanitizer
US20170266090A1 (en) Antimicrobial compositions that are dermatologically non-drying
RU2158143C1 (en) Antiseptic liquid "veltaleks-m"

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 15706521

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 15706521

Country of ref document: EP

Kind code of ref document: A1