AU2021104043A4 - A Polyherbal Gel Composition For Preventing Ill Effect Of Sanitizers. - Google Patents
A Polyherbal Gel Composition For Preventing Ill Effect Of Sanitizers. Download PDFInfo
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- AU2021104043A4 AU2021104043A4 AU2021104043A AU2021104043A AU2021104043A4 AU 2021104043 A4 AU2021104043 A4 AU 2021104043A4 AU 2021104043 A AU2021104043 A AU 2021104043A AU 2021104043 A AU2021104043 A AU 2021104043A AU 2021104043 A4 AU2021104043 A4 AU 2021104043A4
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- 244000144927 Aloe barbadensis Species 0.000 description 2
- 235000002961 Aloe barbadensis Nutrition 0.000 description 2
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- 244000248349 Citrus limon Species 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 241000588747 Klebsiella pneumoniae Species 0.000 description 2
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- 235000013599 spices Nutrition 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 101100519969 Arabidopsis thaliana PHS2 gene Proteins 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000588748 Klebsiella Species 0.000 description 1
- 201000008225 Klebsiella pneumonia Diseases 0.000 description 1
- 241000588652 Neisseria gonorrhoeae Species 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 206010035717 Pneumonia klebsiella Diseases 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 241000588770 Proteus mirabilis Species 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
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- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
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- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 1
- 235000020661 alpha-linolenic acid Nutrition 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 229940027983 antiseptic and disinfectant quaternary ammonium compound Drugs 0.000 description 1
- -1 aqua deem Chemical compound 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
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- 239000003205 fragrance Substances 0.000 description 1
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- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 description 1
- 229960004488 linolenic acid Drugs 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
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- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
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- 229960003500 triclosan Drugs 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/02—Acyclic compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/10—Apiaceae or Umbelliferae [Carrot family], e.g. parsley, caraway, dill, lovage, fennel or snakebed
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/22—Lamiaceae or Labiatae [Mint family], e.g. thyme, rosemary, skullcap, selfheal, lavender, perilla, pennyroyal, peppermint or spearmint
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/26—Meliaceae [Chinaberry or Mahogany family], e.g. mahogany, langsat or neem
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/36—Rutaceae [Rue family], e.g. lime, orange, lemon, corktree or pricklyash
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/40—Liliopsida [monocotyledons]
- A01N65/42—Aloeaceae [Aloe family] or Liliaceae [Lily family], e.g. aloe, veratrum, onion, garlic or chives
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/40—Liliopsida [monocotyledons]
- A01N65/44—Poaceae or Gramineae [Grass family], e.g. bamboo, lemon grass or citronella grass
Abstract
Alcohol compositions are perfect hand and skin care merchandise. They are powerful in
opposition to an extensive variety of microorganisms. They also are capable of kill
microorganisms quicker than different antimicrobial merchandise. The only problem with
alcohol based sanitizers is due to other constituents present in the sanitizer. A more radical
approach is reducing the synthetic ingredients present in sanitizer by incorporating natural
extracts whose functionality is comparable with their synthetic ingredients. The main advantage
of using natural source is that they are easily available, cheap and harmless compared to
chemical products. In the prepared formulation, the alcohol was used along with oil extract to get
better result. In this study the herbal extract based formulations were formulated which were
used to reduce germs on hand and harmless to hand and alternative to synthetic drugs. This
formulation is advanced hand sanitizer which has moisturizing properties; this is highly effective
against surface microbes.
Description
A Polyherbal Gel Composition For Preventing Ill Effect Of Sanitizers.
The invention relates to polyherbal liquid alcohol based skin sanitizing compositions that are formulated for repeated long term use. The present invention relates generally to improved formulation for the care, protection of skin. The compositions include a level of skin heath components to help and improve the skin health while also maintaining an acceptable skin feel and efficiency. The invention discloses a hand sanitizer containing natural compositions along with isopropyl alcohol for preventing skin from ill effect of sanitizer on long term use.
Skin, particularly palms had to be blanketed from bacterial pathogens as they may be the maximum uncovered part of the body. Proper hand care has lengthy been mentioned as a powerful manner of lowering the unfold of germs, diseases, and different contaminants. Hand washing is the only best powerful and price powerful way for warding off transmission of infectious sickness via way of means of hand. Typically, hand care has involved the washing of hands with soap followed by rinsing the hands with water to remove the soap. However, antimicrobial products that do not require a water rinse because they evaporate off hand. Such products are therefore known to be rinse less hand sanitizers. They have become popular in recent years as another way of sanitizing hands. When such a rinseless hand sanitizer is used, the user applies the product to his/her hands and rubs the hands together so that the product eventually either evaporates or is absorbed into the skin. These antimicrobial products come in the form of lotions, liquid, gels, and foams. Antimicrobial agents that may be used in such products include alcohols, trichlorohydroxy diphenyl ether (Triclosan), parachlorometaxylenol (PCMX), and quaternaryammonium compounds. Among all usable chemicals, ethanol, isopropanol and n-propanol (in the order of increasing efficacy) are the strongest and fasten agents. The most commonly used concentrations alcohol in hand sanitizer formulation ethanol (60-90%), isopropanol (70-80%) and n-propanol (60-70%)
There are many possible advantages of using natural products as antimicrobial compounds, such as fewer adverse effects, better patient tolerance, relatively inexpensive, renewability and biodegradability. Bearing in mind this requirement; an endeavor has been made to display classical collected works for the herbs with antimicrobial properties to formulate low cost polyherbal hand sanitizer from which are known to have antimicrobial activities against disease caused by microorganism. The chemical analysis of different parts of these plants has been reported. as Citrus (Lime) juice, Azadirtia indica (neem),Coleus vettiveroids (hrivera) root powder,coriander(dhania),khus, water and ethanol extracts of Aloe barbaddenis. It was found to contain Flavonoids, phenolic compounds, and proanthocyanidins. Studies revealed that the extracts of root of neem and coriander have been found effective in inhibiting the growth of Staphylococcus aureus, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Beta-haemolytic streptococci, Escherichiacoli and Neisseria gonorrhoeae).
Thus, in the present invention we formulated a polyherbal hand sanitizer including combination of different concentration of plant extracts such as Citrus (Lime) juice, Azadirtia indica (neem),Coleus vettiveroids (hrivera) root powder,coriander(dhania),khus, water and ethanol extracts of Aloe barbaddenis as they possess different medicinal and chemical properties useful for formulating p o 1 y herbal sanitizer.
In one aspect of the present disclosure, a polyherbal composition is disclosed. The disclosed formulation does not have any ill effects on the skin. The hand sanitizer is prepared by mixing the following components in percentage by weight: aloe vera in between 8-15 %, coleus vettiveroids in between 5-10 % , Coriandrum sativum in between 5-10 %, citrus lemon in between 3-5 % ,vetriveria zizaionoids in between 3-5% ,Azadirictica indica in between 4-8
% ,and isopropyl alcohol in between 50 - 60% pure plant spice and the balance of de-ionized water. The composition includes a soothing agent in a therapeutically significant amount and a conditioner. The hand sanitizer is prepared by taking the various components in percentage by weight, adding to a mixing container and uniformly stirring. The hand sanitizer can inhibit bacteria and sterilize, and is abundant in foam and warm to clean; the hand sanitizer, which is added with plant additives, not only provides necessary moisturizing components for cleaned hand skin so as to keep the hand skin moist and delicate, but also effectively protects the skin from being hurt. The hand sanitizer, which contains natural citric acid, has functions of resisting and inhibiting bacteria, and is capable of enhancing anti-aging effect of the skin, improving microcirculation of the skin, and preventing the skin from becoming rough and chapped; the hand sanitizer, after long-term use, can whiten and moisturize the skin.
The embodiments herein and the various features and advantageous details thereof are explained more fully with reference to the non-limiting embodiments that are illustrated in the accompanying drawings and detailed in the following description. Descriptions of well-known components and processing techniques are omitted so as to not unnecessarily obscure the embodiments herein. The examples used herein are intended merely to facilitate an understanding of ways in which the embodiments herein may be practiced and to further enable those of skill in the art to practice the embodiments herein. Accordingly, the examples should not be construed as limiting the scope of the embodiments herein. Throughout this specification and the claims which follow, unless the context requires otherwise, the word "comprise", and variations such as "comprises" and "comprising", will be understood to imply the inclusion of a stated integer or step or group of integers or steps but not the exclusion of any other integer or step or group of integers or steps. As used herein, the singular forms "a", "an", "the" include plural referents unless the context clearly dictates otherwise. Further, the terms "like", "as such", "for example", "including" are meant to introduce examples which further clarify more general subject matter, and should be contemplated for the persons skilled in the art to understand the subject matter. Although this invention has been described in conjunction with the exemplary embodiments' below, it is evident that many alternatives, modifications, and variations will be apparent to those skilled in the art. Accordingly, the exemplary embodiments of the invention as set forth above are intended to be illustrative and not limiting. Various changes may be made without departing from the spirit and scope of the invention.
Method of Preparation
In the present invention the Procedure for formulation of poly herbal Hand Sanitizer:
Firstly Citrus fruit (80 g) was grounded and placed into a 500mL round bottom flask containing 250mL of distilled water. Then, the flask was connected to a Clevenger set up. Distillation was carried out for 2hrs at 80°c. The essential oils evaporated with steam during the distillation process, and was separated from the condensates and collected in the distillate receiver. After collection it was placed in a desired place .The extraction process was done repeatedly to obtain excess volume of oil. The hand sanitizer is prepared by mixing the following components in percentage by weight:
1. Aloe vera in between 8-15 %, coleus vettiveroids in between 5-10 % , Coriandrum sativum in between 5-10 %, citrus lemon in between 3-5 % ,vetriveria zizaionoids in between 3-5%
,Azadirictica indica in between 4-8 % ,and isopropyl alcohol in between 50 - 60% pure plant spice and the balance of de-ionized water.
2.The composition includes a soothing agent in a therapeutically significant amount and a conditioner. The hand sanitizer is prepared by taking the various components in percentage by weight, adding to a mixing container and uniformly stirring.
3. Kept aside for 24 hrs
4.The extract of poly herbs were added to denaturing alcohol with glycerin, Poly sorbate 20, were mixed with aqueous phase.
5. Finally, methyl paraben was added as a preservative and perfume was added.
6. Mixed with slow stirring to obtain uniform product.
The pH was found in the range of 6.8-7.75 which is in mild acidic and neutral range. The pH of Hand sanitizer has been shown to be important for improving and enhancing the qualities of hand, minimizing irritation to the hands and stabilizing the ecological balance of the skin. The current trend to promote hand sanitizer of mild pH is one of the ways to minimize damage to the skin. Mild acidity prevents swelling and promotes tightening of the scales, there by inducing shine .
Other objects, features, and advantages of the embodiment will be apparent from the following description when read with reference to the accompanying drawings. In the drawings, wherein like reference numerals denote corresponding parts throughout the several views. Preferred embodiments of the present invention are herein further described, by way of non limiting example only, with reference to the accompanying tables, in which:
Table 01 enlists evaluation of physicochemical properties
Table 02 enlists Antibacterial activities of alcohol based polyherbal hand sanitizers
Table 03. Antimicrobial activities of polyherbal hand sanitizer
Table 1
Parameter evaluation for sample optimized poly herbal hand sanitizer
Parameter PHSI PHS2 PHS3 PHS4 PHS5 PHS6 PHS7 PHS8
Odor Fragrant Fragrant Fragrant Fragrant Fragrant Fragrant Fragrant Fragrant pH 6.99 6.79 7.80 6.73 7.01 7.3 6.75 6.79 Homogeneity Uniform Uniform Uniform Uniform Uniform Uniform uniform uniform Appearance Liquid Liquid Liquid Liquid Liquid Liquid Liquid Liquid Viscosity 105 41 36 44.33 27 43 54.33 72.67 Colour White Light red Light red Colorless Light red Light Light brown brow brow n n
Table 2
Antibacterial activities of alcohol based polyherbal hand sanitizers
Organism Zone of inhibition and sample code HS1 HS2 HS3 HS4 HS5 HS6 Shigella sonnie - 8.33+0.57 9+1 (ATCC 25931) Escherichiacoli 8+1.12 6.67+0.58 7+1 6.67+0.17 7.33+0.67 7 (ATCC 25922) Entrococcusfeasilis 11.33+1.15 7.33+1.53 10.330.18 9.33+1.17 10.33+1.17 13+1 (ATCC 229212) Staphylococcus 13+2.65 11.67+2.3 12+1 9.67+0.67 9+1 11+1 aureus (ATCC 25923) Pneudomonas(ATCC - -
27853) Klebsiella -
pneumonia(ATC C 700603)
Table3 Antimicrobial activities of polyherbal hand sanitizer
Organism Zone of inhibition in mm and sample code Market HS7 HS8 HS9 HS1O HS11 hand sanitize r Shigella sonnie (ATCC 25931) 11.671.17 12.33+2.17 13+1 10.67±0.17 Escherichia coli(ATCC 25922) 7+1 - 7+1 10 8 Entrococcus feasilis (ATCC 229212) 9 10+1 16+2.65 14.33+1.17 12.67+0.67 Staphylococcus aureus 12+1 7+1 23.33+2.08 14+1 - 7+1 (ATCC 25923) Pneudomonas(ATCC 27853) - - 15±1 15±0.17 - Klebsiella pneumonia(ATC - 12.34±0.18 8±1 C 700603)
The reference hand sanitizer taken from market which includes ingredients such as carbomer, aqua deem, ethanol (60%) and fragrance showed antibacterial activity against Staphylococcus aureus only with zone of inhibition shows 6+1mm and fails to inhibit bacterial growth for most strains of microorganisms when compared to that for the formulated hand sanitizer in this project. This proves that the formulated polyherbal hand sanitizer is preferable and effective. Hand sanitizer having 20-25% plant extracts and 60% isopropanol alcohol was found to be more effective with its zone of inhibition shows 23.332.08mm, when compared to 60%isopropanol alcohol which has 14+1mm zone of inhibition. This shows that polyherbal extract is more effective than isopropanol which has antimicrobial properties.
Our formulation novelty lies in synergistic effects of various herbs used in preparation, for instance they are rich source of linolenic acid, which provide the anti oxidant effect along with skin smoothening benefit.
The alcohols have excellent, rapid (within seconds) germicidal activity against vegetative bacteria, fungi, and many viruses and antibacterial activity is based on protein denaturation of microorganisms. Alcohol sanitizers are highly effective against mycobacteria (the bacteria most resistant to the disinfection process) and multidrug-resistant pathogens. Alcohol rubs are about 100 times more efficient against viruses than any form of hand washing. Sanitizer proposes several advantages over non-alcoholic hand disinfectants, rubbing sanitizers onto both hands and until it completely evaporates usually requires only 15 to 30 seconds. Whereas vigorous friction, rinsing with water, and drying with a towel are not needed like hand disinfectants or soaps
Claims (8)
- Claims1 The formulation claimed here shows synergistic effect of various herbs used and the constituent used also has skin smoothening action, which is beneficial for skin.
- 2 Our formulation prevent skin from the dry, cracking as well as redness, discoloration, flaking effects of normal sanitizers.
- 3 The formulation of claim 1 is different from others as it has Broad spectrum ant-microbial action..
- 4. The formulation of claim 1 Contains herbal bio-actives and is non-toxic, safe to use with no side-effects.
- 5. The formulation of claim 1 kills more than 99.99% of most common germs that may cause illness.
- 6. The formulation of claim 1 is enhanced with a nourishing blend of four different skin conditioners that are clinically proven to help maintain skin heal.
- 7. The formulation of claim 1 kill microorganisms on hands within 30 seconds to one minute after application
- 8. The formulation of claim 1 has almost same pH as skin, so it is skin friendlyEDITORIAL NOTE 11 Jul 20212021104043THERE IS ONE PAGE OF DRAWINGS ONLYAny rough diagrams or figures related to your invention? 11 Jul 2021Ans.
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